TRIM61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)6.96976342
2regulation of meiosis (GO:0040020)6.75976716
3mitotic metaphase plate congression (GO:0007080)6.52365312
4piRNA metabolic process (GO:0034587)6.50777418
5female gamete generation (GO:0007292)6.39607943
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.94800724
7meiotic cell cycle (GO:0051321)5.91941352
8regulation of meiosis I (GO:0060631)5.84820362
9negative regulation of meiosis (GO:0045835)5.78270318
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.74721463
11attachment of spindle microtubules to kinetochore (GO:0008608)5.62126281
12mitotic chromosome condensation (GO:0007076)5.60756631
13metaphase plate congression (GO:0051310)5.34543824
14regulation of meiotic cell cycle (GO:0051445)5.33601178
15negative regulation of hormone biosynthetic process (GO:0032353)5.30898258
16negative regulation of hormone metabolic process (GO:0032351)5.30898258
17regulation of histone H3-K27 methylation (GO:0061085)5.28655580
18maturation of 5.8S rRNA (GO:0000460)5.22796216
19oocyte maturation (GO:0001556)5.22137606
20rRNA modification (GO:0000154)5.04856122
21DNA damage induced protein phosphorylation (GO:0006975)5.02958309
22histone H2A monoubiquitination (GO:0035518)5.00831659
23regulation of exit from mitosis (GO:0007096)4.98967047
24establishment of chromosome localization (GO:0051303)4.83675718
25negative regulation of meiotic cell cycle (GO:0051447)4.82845665
26glycerophospholipid catabolic process (GO:0046475)4.82374372
27male meiosis (GO:0007140)4.80175144
28transcription from mitochondrial promoter (GO:0006390)4.77524802
29mitotic sister chromatid segregation (GO:0000070)4.75964916
30regulation of RIG-I signaling pathway (GO:0039535)4.69988619
31regulation of sister chromatid cohesion (GO:0007063)4.57810582
32chaperone-mediated protein transport (GO:0072321)4.55055641
33proteasome assembly (GO:0043248)4.53032763
34regulation of retinoic acid receptor signaling pathway (GO:0048385)4.51917307
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.51777677
36regulation of DNA methylation (GO:0044030)4.48240940
37meiotic chromosome segregation (GO:0045132)4.47658602
38DNA damage response, signal transduction resulting in transcription (GO:0042772)4.43513386
39rRNA methylation (GO:0031167)4.38883037
40respiratory chain complex IV assembly (GO:0008535)4.25265950
41regulation of glucocorticoid metabolic process (GO:0031943)4.24443278
42monoubiquitinated protein deubiquitination (GO:0035520)4.23636063
43protein localization to kinetochore (GO:0034501)4.20169540
44histone H2A ubiquitination (GO:0033522)4.18352426
45regulation of spindle organization (GO:0090224)4.16529629
46regulation of transforming growth factor beta2 production (GO:0032909)4.16466581
47positive regulation of megakaryocyte differentiation (GO:0045654)4.14727665
48DNA methylation involved in gamete generation (GO:0043046)4.09182498
49protein localization to chromosome, centromeric region (GO:0071459)4.08214354
50type B pancreatic cell development (GO:0003323)4.04028646
51protein K6-linked ubiquitination (GO:0085020)4.01467030
52regulation of mitotic spindle organization (GO:0060236)4.00812540
53protein localization to chromosome (GO:0034502)4.00722364
54regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.93958627
55CENP-A containing nucleosome assembly (GO:0034080)3.88315099
56negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.88032926
57negative regulation of DNA-templated transcription, elongation (GO:0032785)3.88032926
58negative regulation of smooth muscle cell differentiation (GO:0051151)3.87131025
59chromosome segregation (GO:0007059)3.85993009
60female gonad development (GO:0008585)3.84708563
61sister chromatid segregation (GO:0000819)3.82321687
62positive regulation of chromosome segregation (GO:0051984)3.77585725
63chromatin remodeling at centromere (GO:0031055)3.72970553
64termination of RNA polymerase III transcription (GO:0006386)3.71939414
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.71939414
66DNA replication-independent nucleosome assembly (GO:0006336)3.65616114
67DNA replication-independent nucleosome organization (GO:0034724)3.65616114
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.62345587
69pseudouridine synthesis (GO:0001522)3.62047661
70positive regulation of DNA-dependent DNA replication (GO:2000105)3.60966893
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.60672429
72microtubule nucleation (GO:0007020)3.60538142
73spindle checkpoint (GO:0031577)3.57093354
74regulation of chromosome segregation (GO:0051983)3.55835875
75protein neddylation (GO:0045116)3.55742492
76mitotic nuclear envelope disassembly (GO:0007077)3.53891890
77cytochrome complex assembly (GO:0017004)3.53734675
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50586212
79protein complex biogenesis (GO:0070271)3.50423939
80histone exchange (GO:0043486)3.50066614
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47755876
82cytoplasmic mRNA processing body assembly (GO:0033962)3.47479626
83snRNA transcription (GO:0009301)3.46773113
84microtubule severing (GO:0051013)3.45278430
85mitochondrial RNA metabolic process (GO:0000959)3.42202820
86mitochondrial respiratory chain complex I assembly (GO:0032981)3.41102354
87NADH dehydrogenase complex assembly (GO:0010257)3.41102354
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41102354
89positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.40213472
90mitochondrial respiratory chain complex assembly (GO:0033108)3.40056984
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.39510015
92parturition (GO:0007567)3.35732048
93membrane disassembly (GO:0030397)3.35571924
94nuclear envelope disassembly (GO:0051081)3.35571924
95ribosome assembly (GO:0042255)3.33656049
96gene silencing by RNA (GO:0031047)3.33536559
97regulation of cell maturation (GO:1903429)3.31096518
98negative regulation of alcohol biosynthetic process (GO:1902931)3.29356133
99multicellular organism reproduction (GO:0032504)3.26924370
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25947702
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25947702
102regulation of steroid hormone biosynthetic process (GO:0090030)3.25738516
103positive regulation of mitotic sister chromatid separation (GO:1901970)3.24132840
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24132840
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24132840
106DNA replication checkpoint (GO:0000076)3.22546307
107DNA deamination (GO:0045006)3.20421543
108synapsis (GO:0007129)3.20221509
109chromatin assembly or disassembly (GO:0006333)3.20220350
110regulation of mononuclear cell migration (GO:0071675)3.19997755
111mitotic spindle checkpoint (GO:0071174)3.19752146
112mitotic sister chromatid cohesion (GO:0007064)3.19426150
113negative regulation of nuclear division (GO:0051784)3.17912010
114meiotic nuclear division (GO:0007126)3.16540230
115DNA double-strand break processing (GO:0000729)3.16389178
116sister chromatid cohesion (GO:0007062)3.15387894
117negative regulation of cell division (GO:0051782)3.13948882
118DNA alkylation (GO:0006305)3.12549558
119DNA methylation (GO:0006306)3.12549558
120male meiosis I (GO:0007141)3.12293620
121water-soluble vitamin biosynthetic process (GO:0042364)3.10540424
122meiotic cell cycle process (GO:1903046)3.08931641
123positive regulation of Cdc42 GTPase activity (GO:0043089)3.07134569
124meiosis I (GO:0007127)3.06960662
125regulation of steroid hormone secretion (GO:2000831)3.06372133
126mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05590166
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04899274
128centriole replication (GO:0007099)3.04231995
129somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03908148
130somatic hypermutation of immunoglobulin genes (GO:0016446)3.03908148
131negative regulation of reproductive process (GO:2000242)3.02954954
132protein monoubiquitination (GO:0006513)3.01975679
133regulation of acrosome reaction (GO:0060046)3.01327426
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00774720
135regulation of mitotic spindle checkpoint (GO:1903504)3.00774720
136positive regulation of protein homooligomerization (GO:0032464)2.97095210
137protein-cofactor linkage (GO:0018065)2.89743511
138tRNA processing (GO:0008033)2.86717938
139rRNA processing (GO:0006364)2.83416687
140positive regulation of histone H3-K4 methylation (GO:0051571)2.82518349
141replication fork processing (GO:0031297)2.82385225
142protein targeting to mitochondrion (GO:0006626)2.80924357
143retinal cone cell development (GO:0046549)2.80666466
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.79953838
145rRNA metabolic process (GO:0016072)2.77716848
146response to pheromone (GO:0019236)2.76206121
147DNA catabolic process, exonucleolytic (GO:0000738)2.75696684
148protein deneddylation (GO:0000338)2.74535464
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.69058005
150positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67023186
151establishment of protein localization to mitochondrion (GO:0072655)2.65642049
152regulation of mitochondrial translation (GO:0070129)2.65383967
153mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.65324306
154histone mRNA metabolic process (GO:0008334)2.64725307
155DNA damage response, detection of DNA damage (GO:0042769)2.63654385
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62455407
157anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62039347
158spliceosomal snRNP assembly (GO:0000387)2.61866272
159epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60920549
160detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.59403895
161protein localization to mitochondrion (GO:0070585)2.58124174
162regulation of hexokinase activity (GO:1903299)2.56575628
163regulation of glucokinase activity (GO:0033131)2.56575628
164reciprocal DNA recombination (GO:0035825)2.55336617
165reciprocal meiotic recombination (GO:0007131)2.55336617
166negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.54003306
167transcription from RNA polymerase III promoter (GO:0006383)2.53716541
168recombinational repair (GO:0000725)2.52484082
169double-strand break repair via homologous recombination (GO:0000724)2.51758390
170ncRNA processing (GO:0034470)2.50771037
1717-methylguanosine mRNA capping (GO:0006370)2.49372641
172peptidyl-histidine modification (GO:0018202)2.48818984
173regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.48718612
174ncRNA metabolic process (GO:0034660)2.46023692
175behavioral response to nicotine (GO:0035095)2.45699326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.98051377
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67471254
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.11993646
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.03428861
5KAP1_22055183_ChIP-Seq_ESCs_Mouse3.98985056
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.83821095
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.74771537
8E2F7_22180533_ChIP-Seq_HELA_Human3.63744427
9AR_21909140_ChIP-Seq_LNCAP_Human3.52217962
10ZNF274_21170338_ChIP-Seq_K562_Hela3.49563216
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.16467249
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.13116080
13NOTCH1_21737748_ChIP-Seq_TLL_Human3.07399593
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04878468
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98124702
16EZH2_22144423_ChIP-Seq_EOC_Human2.95335550
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.85787281
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.72485394
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60373508
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.59190371
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56786135
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39722351
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38443079
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35876041
25VDR_23849224_ChIP-Seq_CD4+_Human2.32971838
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12636968
27ELK1_19687146_ChIP-ChIP_HELA_Human2.09993342
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09497945
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07281482
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07122842
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96695738
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.91508226
33FOXP3_21729870_ChIP-Seq_TREG_Human1.89749752
34RUNX1_26923725_Chip-Seq_HPCs_Mouse1.89469331
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86610817
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.86107351
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80176836
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.78428706
39IGF1R_20145208_ChIP-Seq_DFB_Human1.78095562
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75521138
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69871188
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.66042448
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65685278
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65146365
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61575515
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59549928
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58511083
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58384214
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.56696547
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54845480
51FUS_26573619_Chip-Seq_HEK293_Human1.54518719
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53807742
53MYC_18940864_ChIP-ChIP_HL60_Human1.52861112
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48677313
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48597953
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46722744
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43874459
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42964674
59RNF2_27304074_Chip-Seq_NSC_Mouse1.42037148
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41707712
61TP53_22573176_ChIP-Seq_HFKS_Human1.39821652
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38878210
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38346598
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38113719
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37927290
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36583330
67P300_19829295_ChIP-Seq_ESCs_Human1.36112531
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35826747
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35627288
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35067949
71GABP_19822575_ChIP-Seq_HepG2_Human1.33797801
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33307365
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32229214
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32069541
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31639709
76TTF2_22483619_ChIP-Seq_HELA_Human1.29731206
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.28529348
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.28242173
79IRF1_19129219_ChIP-ChIP_H3396_Human1.27091901
80STAT3_23295773_ChIP-Seq_U87_Human1.26981418
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26145781
82STAT1_17558387_ChIP-Seq_HELA_Human1.25618452
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.25539127
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25501319
85DCP1A_22483619_ChIP-Seq_HELA_Human1.24206922
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22223106
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.21966358
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21443974
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19226056
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18871981
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18635839
92GBX2_23144817_ChIP-Seq_PC3_Human1.18633336
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18507238
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17693826
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17307543
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17307543
97* CDX2_22108803_ChIP-Seq_LS180_Human1.16863680
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16642812
99CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15462965
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15364377
101TAF15_26573619_Chip-Seq_HEK293_Human1.15091900
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13836106
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13124707
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12753062
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12661101
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09503780
107EWS_26573619_Chip-Seq_HEK293_Human1.08840609
108NANOG_19829295_ChIP-Seq_ESCs_Human1.08536087
109SOX2_19829295_ChIP-Seq_ESCs_Human1.08536087
110ERG_20517297_ChIP-Seq_VCAP_Human1.07682004
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07402336
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06435485
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05146786
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04338611
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04002128
116NANOG_21062744_ChIP-ChIP_HESCs_Human1.03991802
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02161640
118BCAT_22108803_ChIP-Seq_LS180_Human1.02160281
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01904521
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01233610
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00764893
122NFYA_21822215_ChIP-Seq_K562_Human1.00698766
123GATA3_21867929_ChIP-Seq_TH1_Mouse1.00517615
124SOX2_16153702_ChIP-ChIP_HESCs_Human1.00272526
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99882144
126MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99409892
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.98612115
128* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98397591
129* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98397591
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.98320552
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97720174
132CBP_20019798_ChIP-Seq_JUKART_Human0.97720174
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97340962
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96967021
135AR_21572438_ChIP-Seq_LNCaP_Human0.96880604
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96872105
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94485907
138E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94098304
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93264175
140KDM2B_26808549_Chip-Seq_REH_Human0.92965392
141KLF4_18555785_Chip-Seq_ESCs_Mouse0.91886096
142PHF8_20622853_ChIP-Seq_HELA_Human0.91746697
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91682160
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.91631549
145TBL1_22424771_ChIP-Seq_293T_Human0.91555051
146EZH2_27294783_Chip-Seq_NPCs_Mouse0.91489218
147HTT_18923047_ChIP-ChIP_STHdh_Human0.91308868
148NCOR_22424771_ChIP-Seq_293T_Human0.91103778
149VDR_22108803_ChIP-Seq_LS180_Human0.90979627
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89505369
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89492249
152MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89385324
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89153672
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.89023321
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88118561
156NANOG_16153702_ChIP-ChIP_HESCs_Human0.87896364
157* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87880027
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87824912
159CTCF_18555785_Chip-Seq_ESCs_Mouse0.87563398
160KDM5A_27292631_Chip-Seq_BREAST_Human0.87449699
161KAP1_27257070_Chip-Seq_ESCs_Mouse0.87244992
162SOX2_18555785_Chip-Seq_ESCs_Mouse0.87146924
163NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87019838
164RBPJ_21746931_ChIP-Seq_IB4_Human0.86515668
165AR_20517297_ChIP-Seq_VCAP_Human0.86235056
166PIAS1_25552417_ChIP-Seq_VCAP_Human0.86216844
167NMYC_18555785_Chip-Seq_ESCs_Mouse0.86201955
168TAL1_26923725_Chip-Seq_HPCs_Mouse0.85963217
169FOXH1_21741376_ChIP-Seq_EPCs_Human0.85402060
170SMAD4_21799915_ChIP-Seq_A2780_Human0.85110855
171PRDM14_20953172_ChIP-Seq_ESCs_Human0.83274914
172EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81761817
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81690817
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81622939
175FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81614808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.62099603
2MP0003718_maternal_effect5.72458105
3MP0002102_abnormal_ear_morphology5.31164693
4MP0003646_muscle_fatigue5.16011998
5MP0001986_abnormal_taste_sensitivity4.27436438
6MP0003693_abnormal_embryo_hatching3.84086578
7MP0002653_abnormal_ependyma_morphology3.72258097
8MP0008877_abnormal_DNA_methylation3.26993065
9MP0010094_abnormal_chromosome_stability3.13288868
10MP0003111_abnormal_nucleus_morphology2.80867737
11MP0005423_abnormal_somatic_nervous2.78845332
12MP0003195_calcinosis2.77007823
13MP0001119_abnormal_female_reproductive2.71682912
14MP0005395_other_phenotype2.71074794
15MP0003077_abnormal_cell_cycle2.70105958
16MP0005408_hypopigmentation2.68414699
17MP0003699_abnormal_female_reproductive2.61717640
18MP0003123_paternal_imprinting2.37639046
19MP0004957_abnormal_blastocyst_morpholog2.31085391
20MP0002249_abnormal_larynx_morphology2.16341417
21MP0003787_abnormal_imprinting2.11115850
22MP0000653_abnormal_sex_gland2.10680069
23MP0001929_abnormal_gametogenesis2.09634939
24MP0005645_abnormal_hypothalamus_physiol1.97291438
25MP0003011_delayed_dark_adaptation1.96909994
26MP0008789_abnormal_olfactory_epithelium1.96363510
27MP0002837_dystrophic_cardiac_calcinosis1.93515692
28MP0002210_abnormal_sex_determination1.87646464
29MP0000579_abnormal_nail_morphology1.86567826
30MP0003937_abnormal_limbs/digits/tail_de1.81773024
31MP0006292_abnormal_olfactory_placode1.80345063
32MP0002163_abnormal_gland_morphology1.77174530
33MP0005551_abnormal_eye_electrophysiolog1.74962778
34MP0003121_genomic_imprinting1.73467806
35MP0003880_abnormal_central_pattern1.69134600
36MP0002160_abnormal_reproductive_system1.63448833
37MP0000462_abnormal_digestive_system1.61061867
38MP0006036_abnormal_mitochondrial_physio1.60371524
39MP0004185_abnormal_adipocyte_glucose1.55999856
40MP0005379_endocrine/exocrine_gland_phen1.55364693
41MP0008995_early_reproductive_senescence1.54657627
42MP0008932_abnormal_embryonic_tissue1.54472456
43MP0001529_abnormal_vocalization1.50833776
44MP0003786_premature_aging1.50093810
45MP0002139_abnormal_hepatobiliary_system1.48769660
46MP0000372_irregular_coat_pigmentation1.48492913
47MP0003136_yellow_coat_color1.46624295
48MP0006035_abnormal_mitochondrial_morpho1.46539678
49MP0005499_abnormal_olfactory_system1.44461918
50MP0005394_taste/olfaction_phenotype1.44461918
51MP0010368_abnormal_lymphatic_system1.41774930
52MP0001915_intracranial_hemorrhage1.41226198
53MP0004264_abnormal_extraembryonic_tissu1.41127995
54MP0010234_abnormal_vibrissa_follicle1.40142702
55MP0002161_abnormal_fertility/fecundity1.39834117
56MP0005310_abnormal_salivary_gland1.38869064
57MP0008007_abnormal_cellular_replicative1.35780746
58MP0001145_abnormal_male_reproductive1.33495483
59MP0002085_abnormal_embryonic_tissue1.30511143
60MP0000639_abnormal_adrenal_gland1.28845596
61MP0005646_abnormal_pituitary_gland1.27737676
62MP0002277_abnormal_respiratory_mucosa1.25756070
63MP0000350_abnormal_cell_proliferation1.24968995
64MP0004133_heterotaxia1.23458672
65MP0005253_abnormal_eye_physiology1.22852970
66MP0003186_abnormal_redox_activity1.22642821
67MP0002138_abnormal_hepatobiliary_system1.22239813
68MP0004142_abnormal_muscle_tone1.22220172
69MP0001293_anophthalmia1.19069674
70MP0001905_abnormal_dopamine_level1.18901252
71MP0001730_embryonic_growth_arrest1.18857405
72MP0001697_abnormal_embryo_size1.18521074
73MP0009046_muscle_twitch1.14217113
74MP0005084_abnormal_gallbladder_morpholo1.13511821
75MP0002084_abnormal_developmental_patter1.12547465
76MP0003119_abnormal_digestive_system1.11934206
77MP0006276_abnormal_autonomic_nervous1.10360564
78MP0005410_abnormal_fertilization1.10340211
79MP0001968_abnormal_touch/_nociception1.08603036
80MP0004043_abnormal_pH_regulation1.07153360
81MP0004510_myositis1.05347903
82MP0001764_abnormal_homeostasis1.04470664
83MP0001984_abnormal_olfaction1.04206790
84MP0003315_abnormal_perineum_morphology1.02497134
85MP0002234_abnormal_pharynx_morphology1.01750878
86MP0002938_white_spotting1.00372226
87MP0002751_abnormal_autonomic_nervous0.98596243
88MP0002638_abnormal_pupillary_reflex0.97094904
89MP0001485_abnormal_pinna_reflex0.95754115
90MP0002877_abnormal_melanocyte_morpholog0.94114995
91MP0009697_abnormal_copulation0.93767109
92MP0002272_abnormal_nervous_system0.93695526
93MP0004145_abnormal_muscle_electrophysio0.93049417
94MP0001486_abnormal_startle_reflex0.92920999
95MP0003252_abnormal_bile_duct0.90695026
96MP0001851_eye_inflammation0.90636882
97MP0001346_abnormal_lacrimal_gland0.89979747
98MP0002019_abnormal_tumor_incidence0.89368255
99MP0001672_abnormal_embryogenesis/_devel0.89059269
100MP0005380_embryogenesis_phenotype0.89059269
101MP0009745_abnormal_behavioral_response0.88501242
102MP0004215_abnormal_myocardial_fiber0.86930245
103MP0008875_abnormal_xenobiotic_pharmacok0.86878412
104MP0010386_abnormal_urinary_bladder0.85953132
105MP0001849_ear_inflammation0.84929914
106MP0003755_abnormal_palate_morphology0.84657405
107MP0002876_abnormal_thyroid_physiology0.84168201
108MP0008260_abnormal_autophagy0.82858870
109MP0008872_abnormal_physiological_respon0.80975618
110MP0004019_abnormal_vitamin_homeostasis0.80095165
111MP0003656_abnormal_erythrocyte_physiolo0.79670725
112MP0001286_abnormal_eye_development0.79643850
113MP0009250_abnormal_appendicular_skeleto0.79287049
114MP0005220_abnormal_exocrine_pancreas0.78391910
115MP0000427_abnormal_hair_cycle0.76930769
116MP0003698_abnormal_male_reproductive0.76625724
117MP0002177_abnormal_outer_ear0.76285283
118MP0002736_abnormal_nociception_after0.75098305
119MP0003453_abnormal_keratinocyte_physiol0.74971824
120MP0005085_abnormal_gallbladder_physiolo0.74736584
121MP0004885_abnormal_endolymph0.73043767
122MP0005647_abnormal_sex_gland0.72689395
123MP0005075_abnormal_melanosome_morpholog0.72172503
124MP0002127_abnormal_cardiovascular_syste0.72139912
125MP0000490_abnormal_crypts_of0.71297815
126MP0001944_abnormal_pancreas_morphology0.71068949
127MP0003567_abnormal_fetal_cardiomyocyte0.70969940
128MP0000647_abnormal_sebaceous_gland0.70796270
129MP0005621_abnormal_cell_physiology0.70381961
130MP0003329_amyloid_beta_deposits0.68220729
131MP0000678_abnormal_parathyroid_gland0.65471851
132MP0004270_analgesia0.65089417
133MP0008058_abnormal_DNA_repair0.65022614
134MP0006072_abnormal_retinal_apoptosis0.64067564
135MP0002168_other_aberrant_phenotype0.63403371
136MP0005187_abnormal_penis_morphology0.61880075
137MP0003950_abnormal_plasma_membrane0.61739327
138MP0002116_abnormal_craniofacial_bone0.61079703
139MP0003984_embryonic_growth_retardation0.59876121
140MP0001919_abnormal_reproductive_system0.59246618
141MP0002932_abnormal_joint_morphology0.58101179
142MP0000631_abnormal_neuroendocrine_gland0.57425470
143MP0008057_abnormal_DNA_replication0.56916282
144MP0002088_abnormal_embryonic_growth/wei0.56072201
145MP0002086_abnormal_extraembryonic_tissu0.55697594
146MP0002080_prenatal_lethality0.55490930
147MP0003861_abnormal_nervous_system0.55379311
148MP0003890_abnormal_embryonic-extraembry0.55296414
149MP0000566_synostosis0.54024505
150MP0002295_abnormal_pulmonary_circulatio0.52748659
151MP0002233_abnormal_nose_morphology0.51973592
152MP0000432_abnormal_head_morphology0.51781480
153MP0010030_abnormal_orbit_morphology0.50508216
154MP0005389_reproductive_system_phenotype0.50183681
155MP0001502_abnormal_circadian_rhythm0.49721679
156MP0010307_abnormal_tumor_latency0.48702116
157MP0005197_abnormal_uvea_morphology0.48232090
158MP0003935_abnormal_craniofacial_develop0.48113416
159MP0002109_abnormal_limb_morphology0.47959922
160MP0005508_abnormal_skeleton_morphology0.47847933
161MP0009384_cardiac_valve_regurgitation0.46998244
162MP0005384_cellular_phenotype0.46829892

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.81300286
2Papillary thyroid carcinoma (HP:0002895)5.32119988
3Birth length less than 3rd percentile (HP:0003561)4.60657063
4Chromsome breakage (HP:0040012)4.56832442
5Adrenal hypoplasia (HP:0000835)4.37728272
6Breast hypoplasia (HP:0003187)4.35318750
7Shawl scrotum (HP:0000049)4.29351026
8Facial hemangioma (HP:0000329)4.29060076
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14397529
10Flat capital femoral epiphysis (HP:0003370)4.05148966
11Abnormality of the labia minora (HP:0012880)4.00760699
12Patellar aplasia (HP:0006443)3.97302716
13Secondary amenorrhea (HP:0000869)3.75034733
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.68347651
15Aplasia/Hypoplasia of the patella (HP:0006498)3.66799367
16Capillary hemangiomas (HP:0005306)3.49612129
17Arterial tortuosity (HP:0005116)3.41681967
18Abnormality of the fingertips (HP:0001211)3.34610231
19Increased hepatocellular lipid droplets (HP:0006565)3.23654438
20Abnormality of lateral ventricle (HP:0030047)3.18593564
21Increased CSF lactate (HP:0002490)3.15770313
22Acute necrotizing encephalopathy (HP:0006965)3.15208330
23Premature ovarian failure (HP:0008209)3.14719981
24Cortical dysplasia (HP:0002539)3.11943955
25Acute myeloid leukemia (HP:0004808)3.10286256
26Abnormality of midbrain morphology (HP:0002418)3.09603664
27Molar tooth sign on MRI (HP:0002419)3.09603664
28Infertility (HP:0000789)3.09504788
29Hypergonadotropic hypogonadism (HP:0000815)3.07246714
30Pancreatic cysts (HP:0001737)3.06533292
31Mitochondrial inheritance (HP:0001427)3.06362636
32Pulmonary fibrosis (HP:0002206)3.02343390
33Breast aplasia (HP:0100783)3.00283406
34Lipid accumulation in hepatocytes (HP:0006561)3.00115055
35Aplasia/Hypoplasia of the breasts (HP:0010311)2.98871302
36Vascular tortuosity (HP:0004948)2.94074496
37Spondylolisthesis (HP:0003302)2.93957603
38Abnormality of chromosome segregation (HP:0002916)2.93455546
39Renal Fanconi syndrome (HP:0001994)2.91605286
40Progressive macrocephaly (HP:0004481)2.88446928
41Thyroid carcinoma (HP:0002890)2.82707306
42Methylmalonic acidemia (HP:0002912)2.82488324
43Sandal gap (HP:0001852)2.81323540
44Oligodactyly (hands) (HP:0001180)2.81222687
45Aplasia/hypoplasia of the uterus (HP:0008684)2.75408578
46True hermaphroditism (HP:0010459)2.75139546
47Chronic bronchitis (HP:0004469)2.73331416
48Abnormality of chromosome stability (HP:0003220)2.72077979
49Exertional dyspnea (HP:0002875)2.69874216
50Overlapping toe (HP:0001845)2.67914210
51Lip pit (HP:0100267)2.66334380
52Acute encephalopathy (HP:0006846)2.66037547
53Abnormal mitochondria in muscle tissue (HP:0008316)2.63762174
54Hepatocellular necrosis (HP:0001404)2.63240688
55Insulin-resistant diabetes mellitus (HP:0000831)2.59188138
56Oligodactyly (HP:0012165)2.52000974
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51141713
58Hepatic necrosis (HP:0002605)2.50196261
59Abnormality of urine glucose concentration (HP:0011016)2.49662633
60Glycosuria (HP:0003076)2.49662633
61Deep venous thrombosis (HP:0002625)2.46667516
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.43472929
63Supernumerary spleens (HP:0009799)2.43100832
64Increased serum lactate (HP:0002151)2.41273571
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.39106362
66Short tibia (HP:0005736)2.38873112
67Abnormality of the preputium (HP:0100587)2.37043829
68Primary amenorrhea (HP:0000786)2.36842103
69Methylmalonic aciduria (HP:0012120)2.35686451
70Sparse lateral eyebrow (HP:0005338)2.35540402
71Medial flaring of the eyebrow (HP:0010747)2.33569157
72Hyperinsulinemic hypoglycemia (HP:0000825)2.31380737
73Hypoplasia of the uterus (HP:0000013)2.30525242
74Rib fusion (HP:0000902)2.29507498
75Absent septum pellucidum (HP:0001331)2.28708966
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.28335148
77Septo-optic dysplasia (HP:0100842)2.25235048
78Cystic hygroma (HP:0000476)2.24634114
79Tubulointerstitial nephritis (HP:0001970)2.24305456
80Median cleft lip (HP:0000161)2.23674462
81Meckel diverticulum (HP:0002245)2.21797509
82Abnormality of the proximal phalanges of the hand (HP:0009834)2.19983577
83Abnormality of the septum pellucidum (HP:0007375)2.19909048
84Nephronophthisis (HP:0000090)2.19058036
85Wrist flexion contracture (HP:0001239)2.18772684
86Ectopic kidney (HP:0000086)2.18727594
87Congenital stationary night blindness (HP:0007642)2.18703577
88Prostate neoplasm (HP:0100787)2.18078155
89Abnormality of vitamin B metabolism (HP:0004340)2.16388138
90Abnormality of the epiphysis of the femoral head (HP:0010574)2.15858786
91Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15632768
92Absent radius (HP:0003974)2.14675392
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14541449
94Hypoplastic iliac wings (HP:0002866)2.14030590
95Fibular aplasia (HP:0002990)2.13378328
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.12713806
97Absent/shortened dynein arms (HP:0200106)2.12713806
98Small intestinal stenosis (HP:0012848)2.10602346
99Duodenal stenosis (HP:0100867)2.10602346
100Abnormality of the phalanges of the hallux (HP:0010057)2.10428055
101Fetal akinesia sequence (HP:0001989)2.09576001
102Aplasia involving forearm bones (HP:0009822)2.07995889
103Absent forearm bone (HP:0003953)2.07995889
104Pancreatic fibrosis (HP:0100732)2.06154204
105Abnormality of the ileum (HP:0001549)2.05357968
106Colon cancer (HP:0003003)2.05334726
107Gonadotropin excess (HP:0000837)2.05152314
108Carpal bone hypoplasia (HP:0001498)2.05000209
109Abnormality of abdominal situs (HP:0011620)2.03715065
110Abdominal situs inversus (HP:0003363)2.03715065
111Myelodysplasia (HP:0002863)2.03463925
112Abnormal lung lobation (HP:0002101)2.03298622
113Progressive inability to walk (HP:0002505)2.03132261
114Microvesicular hepatic steatosis (HP:0001414)2.02447195
115Abnormality of the fovea (HP:0000493)2.02312464
116Short thumb (HP:0009778)2.00455921
117Midline defect of the nose (HP:0004122)1.99838140
118Anencephaly (HP:0002323)1.99546362
119Abnormal gallbladder physiology (HP:0012438)1.98940483
120Cholecystitis (HP:0001082)1.98940483
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.97611274
122Abnormality of the femoral head (HP:0003368)1.97548518
123Nonprogressive disorder (HP:0003680)1.96509748
124Abnormality of the renal cortex (HP:0011035)1.96315863
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94645463
126Abnormality of placental membranes (HP:0011409)1.94462891
127Amniotic constriction ring (HP:0009775)1.94462891
128Abnormality of the vitamin B12 metabolism (HP:0004341)1.94222662
129Abnormality of femoral epiphyses (HP:0006499)1.94165221
130Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.94165221
131Hyperglycemia (HP:0003074)1.94024396
132Renal cortical cysts (HP:0000803)1.93746222
133Anterior segment dysgenesis (HP:0007700)1.92791377
134Double outlet right ventricle (HP:0001719)1.92430834
135Congenital malformation of the right heart (HP:0011723)1.92430834
136Abnormal pancreas size (HP:0012094)1.90786684
137Abnormality of the pons (HP:0007361)1.90384793
138Hypomagnesemia (HP:0002917)1.90001454
139Lactic acidosis (HP:0003128)1.89510794
140Abnormality of the renal medulla (HP:0100957)1.89401357
141Rhabdomyosarcoma (HP:0002859)1.89122304
142Hypoplasia of the fovea (HP:0007750)1.88901527
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.88901527
144Sloping forehead (HP:0000340)1.87667198
145Clubbing of toes (HP:0100760)1.86080417
146Sclerocornea (HP:0000647)1.85529163
147Hypoplasia of the pons (HP:0012110)1.84999577
148Hyperglycinemia (HP:0002154)1.84576331
149Absent thumb (HP:0009777)1.84160267
150Horseshoe kidney (HP:0000085)1.83989350
151Type I transferrin isoform profile (HP:0003642)1.83460654
152Type 2 muscle fiber atrophy (HP:0003554)1.83388199
153Camptodactyly of toe (HP:0001836)1.82972130
154Tetany (HP:0001281)1.82721232
155Microglossia (HP:0000171)1.81272015
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80232364
157Cafe-au-lait spot (HP:0000957)1.79670254
158Abolished electroretinogram (ERG) (HP:0000550)1.79198585
159Hypoglycemic coma (HP:0001325)1.79000683
160Chin dimple (HP:0010751)1.78717933
161Abnormal number of erythroid precursors (HP:0012131)1.78209534
162Aplastic anemia (HP:0001915)1.78028491
163Cerebral edema (HP:0002181)1.77928419
164Optic disc pallor (HP:0000543)1.77753535
165Abnormality of the intervertebral disk (HP:0005108)1.77732485
166Congenital primary aphakia (HP:0007707)1.76744566
167Abnormal rod and cone electroretinograms (HP:0008323)1.76261267
168Decreased central vision (HP:0007663)1.75761574
169Attenuation of retinal blood vessels (HP:0007843)1.73946141
1703-Methylglutaconic aciduria (HP:0003535)1.73602202
171Intestinal atresia (HP:0011100)1.73182752
172Proximal tubulopathy (HP:0000114)1.72668500
173Muscle fiber atrophy (HP:0100295)1.72413256
174Oral leukoplakia (HP:0002745)1.72181637
175Nephroblastoma (Wilms tumor) (HP:0002667)1.71952768
176Reduced antithrombin III activity (HP:0001976)1.71197235
177Nephrogenic diabetes insipidus (HP:0009806)1.70299795
178Hypothermia (HP:0002045)1.69979424
179Neoplasm of the oral cavity (HP:0100649)1.69674761
180Pendular nystagmus (HP:0012043)1.69573490
181Abnormal ciliary motility (HP:0012262)1.68602656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.78393663
2LATS13.78182175
3KSR23.63400507
4MOS3.62279074
5MAP3K63.54439891
6LATS23.44774480
7PLK43.39132078
8TNIK3.36597618
9MUSK3.35155657
10EEF2K3.23717292
11MAP3K93.09307051
12ERBB43.07753430
13WNK33.06871681
14TTK2.86710899
15BRAF2.86333376
16BMPR22.85261911
17FRK2.80301924
18MAP3K132.66308359
19STK38L2.62254932
20ZAK2.59645172
21TRIM282.57815686
22TAOK12.53619447
23RAF12.53413790
24ARAF2.38259490
25BRSK22.37864600
26EIF2AK32.33665203
27CDC72.26806679
28MAPKAPK32.19889200
29GRK12.18822898
30SRPK12.15657235
31VRK22.15394223
32MST42.11132169
33TSSK61.97895238
34PNCK1.97885338
35ADRBK21.80374597
36CDK81.73921873
37KSR11.69691094
38PAK61.63408168
39MELK1.53746278
40CDK91.49749417
41MKNK21.46827781
42STK31.46091428
43STK161.45465963
44NEK21.42658708
45PBK1.33874048
46DYRK21.23005516
47CHEK21.20928051
48MAPKAPK51.16459564
49EIF2AK11.16338911
50STK101.15862086
51PRKD31.15053033
52WEE11.14350552
53TIE11.12287669
54MAPK131.11092069
55OXSR11.10315019
56PLK11.09733697
57CDK191.03837459
58MKNK11.03124948
59INSRR1.02870408
60BCKDK1.01003489
61MAP3K40.98903610
62TLK10.92762552
63MAP4K20.88966766
64MAP3K80.87741064
65TAF10.87314560
66PRKD20.84476706
67DMPK0.83812992
68TRPM70.79456682
69ABL20.77520587
70TYRO30.76974766
71WNK40.76014124
72STK380.75599015
73MARK20.73797741
74PDK20.72844219
75STK390.72816909
76ACVR1B0.72684419
77PRKAA20.71213203
78NTRK30.70930824
79RPS6KB20.69349309
80PRKCE0.68060102
81BUB10.67672121
82DYRK30.67295453
83RET0.67038490
84MARK30.66262297
85NME10.64722852
86TEC0.64454912
87AURKB0.64165842
88NLK0.62998369
89CSNK1G10.60892415
90PRKCG0.60214497
91MAP2K70.60079663
92PRKAA10.56574854
93STK40.55526433
94CSNK2A10.55408789
95PASK0.54334539
96NUAK10.53671343
97FGFR20.53361514
98PHKG10.53295244
99PHKG20.53295244
100AURKA0.51100267
101ERBB30.50946825
102PLK30.49904832
103MAP2K60.49755529
104PKN10.49686047
105BCR0.48454856
106CSNK2A20.46879245
107MAP2K40.45993667
108CSNK1G20.45682310
109MAP3K50.44703486
110CSNK1E0.44156963
111NEK60.43656844
112EIF2AK20.42011636
113MAPK110.41768852
114CASK0.41118355
115NEK90.40290026
116PINK10.39497857
117SGK20.39320720
118MAP3K120.39248354
119CSNK1G30.39208679
120TESK20.39154807
121NEK10.38457562
122EPHA30.38365471
123NTRK20.37530324
124PRKG10.37174144
125EPHA40.37018632
126STK240.36803477
127CHEK10.36730911
128CSNK1A10.36499917
129ADRBK10.35793173
130PIM10.34879190
131ATM0.34531661
132MAP3K10.33616793
133CDK30.32252152
134PRKACA0.30171363
135MAP2K10.28806126
136CAMK2A0.27865945
137CDK40.25735529
138HIPK20.25148096
139CDK70.24821425
140SGK2230.24671267
141SGK4940.24671267
142BMPR1B0.23654291
143CSNK1A1L0.23327817
144ABL10.21754303
145BRSK10.21746220
146CDK10.21332533
147JAK30.20096789
148PAK30.17956316
149CDK20.17938917
150VRK10.17235065
151FGR0.16685327
152PAK10.16119910
153JAK20.15498532
154CDK120.15085888
155PRKCI0.09550947
156CDK150.09223776
157PLK20.08766679
158CSNK1D0.08677798
159ATR0.08562466
160SGK30.08239598
161RPS6KA40.08055712
162MAPK100.07718644

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041104.29569895
2Ovarian steroidogenesis_Homo sapiens_hsa049134.18964003
3RNA degradation_Homo sapiens_hsa030183.86223877
4Circadian rhythm_Homo sapiens_hsa047103.26660601
5Basal transcription factors_Homo sapiens_hsa030223.22694182
6Vitamin B6 metabolism_Homo sapiens_hsa007502.97953609
7Protein export_Homo sapiens_hsa030602.81185219
8Proteasome_Homo sapiens_hsa030502.80500752
9Oxidative phosphorylation_Homo sapiens_hsa001902.57713114
10Ribosome_Homo sapiens_hsa030102.53101078
11Oocyte meiosis_Homo sapiens_hsa041142.51986301
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48402420
13Pancreatic cancer_Homo sapiens_hsa052122.47457812
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.47263456
15Linoleic acid metabolism_Homo sapiens_hsa005912.44641629
16Parkinsons disease_Homo sapiens_hsa050122.24231774
17Ether lipid metabolism_Homo sapiens_hsa005652.21862941
18Regulation of autophagy_Homo sapiens_hsa041402.09640718
19TGF-beta signaling pathway_Homo sapiens_hsa043502.07019570
20Selenocompound metabolism_Homo sapiens_hsa004501.93547009
21Homologous recombination_Homo sapiens_hsa034401.89675436
22p53 signaling pathway_Homo sapiens_hsa041151.89658838
23Fanconi anemia pathway_Homo sapiens_hsa034601.85034481
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83215714
25One carbon pool by folate_Homo sapiens_hsa006701.82229202
26Huntingtons disease_Homo sapiens_hsa050161.75660760
27GnRH signaling pathway_Homo sapiens_hsa049121.72785799
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.72640529
29Dorso-ventral axis formation_Homo sapiens_hsa043201.63242045
30Steroid biosynthesis_Homo sapiens_hsa001001.62416268
31Spliceosome_Homo sapiens_hsa030401.58657872
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57710785
33Phototransduction_Homo sapiens_hsa047441.56693437
34Base excision repair_Homo sapiens_hsa034101.56584001
35Prolactin signaling pathway_Homo sapiens_hsa049171.55540673
36Choline metabolism in cancer_Homo sapiens_hsa052311.52071369
37Fatty acid elongation_Homo sapiens_hsa000621.51243471
38RNA transport_Homo sapiens_hsa030131.51140760
39Colorectal cancer_Homo sapiens_hsa052101.50507149
40RNA polymerase_Homo sapiens_hsa030201.46191733
41Propanoate metabolism_Homo sapiens_hsa006401.42209136
42MicroRNAs in cancer_Homo sapiens_hsa052061.41830082
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41650412
44Non-homologous end-joining_Homo sapiens_hsa034501.40214344
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27610134
46VEGF signaling pathway_Homo sapiens_hsa043701.23292788
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23247224
48Butanoate metabolism_Homo sapiens_hsa006501.18222058
49DNA replication_Homo sapiens_hsa030301.18024856
50Caffeine metabolism_Homo sapiens_hsa002321.17885400
51Renal cell carcinoma_Homo sapiens_hsa052111.16999866
52Alzheimers disease_Homo sapiens_hsa050101.15282977
53Nucleotide excision repair_Homo sapiens_hsa034201.09895908
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09673378
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.06628067
56Long-term depression_Homo sapiens_hsa047301.05555119
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04888572
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02203134
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02116957
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99967516
61Adherens junction_Homo sapiens_hsa045200.99869541
62Cardiac muscle contraction_Homo sapiens_hsa042600.98793384
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.97861397
64Endometrial cancer_Homo sapiens_hsa052130.97328280
65Taste transduction_Homo sapiens_hsa047420.96440032
66FoxO signaling pathway_Homo sapiens_hsa040680.95789875
67Hippo signaling pathway_Homo sapiens_hsa043900.95431478
68Mismatch repair_Homo sapiens_hsa034300.94687024
69Thyroid cancer_Homo sapiens_hsa052160.92738123
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92642660
71mRNA surveillance pathway_Homo sapiens_hsa030150.91101884
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85244364
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83608582
74Notch signaling pathway_Homo sapiens_hsa043300.82281463
75Sulfur metabolism_Homo sapiens_hsa009200.82026286
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81484327
77Peroxisome_Homo sapiens_hsa041460.81407892
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81066915
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.80598347
80Nitrogen metabolism_Homo sapiens_hsa009100.80501651
81Ras signaling pathway_Homo sapiens_hsa040140.78785354
82Collecting duct acid secretion_Homo sapiens_hsa049660.78476070
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78232884
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78105234
85Glutathione metabolism_Homo sapiens_hsa004800.76160941
86Chronic myeloid leukemia_Homo sapiens_hsa052200.75737522
87Small cell lung cancer_Homo sapiens_hsa052220.74272362
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74095942
89Folate biosynthesis_Homo sapiens_hsa007900.73612348
90Non-small cell lung cancer_Homo sapiens_hsa052230.73091909
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71970752
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71920342
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71704911
94Metabolic pathways_Homo sapiens_hsa011000.71671100
95Nicotine addiction_Homo sapiens_hsa050330.70341114
96Bladder cancer_Homo sapiens_hsa052190.69333520
97Tryptophan metabolism_Homo sapiens_hsa003800.69328100
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68600499
99mTOR signaling pathway_Homo sapiens_hsa041500.65907273
100Hepatitis B_Homo sapiens_hsa051610.64927541
101Retinol metabolism_Homo sapiens_hsa008300.64200980
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64125957
103Estrogen signaling pathway_Homo sapiens_hsa049150.61308121
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56877990
105Arachidonic acid metabolism_Homo sapiens_hsa005900.56274134
106Pyruvate metabolism_Homo sapiens_hsa006200.55926601
107Prostate cancer_Homo sapiens_hsa052150.55618411
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.54753743
109ErbB signaling pathway_Homo sapiens_hsa040120.54530758
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.54455410
111beta-Alanine metabolism_Homo sapiens_hsa004100.53020194
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52875793
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52852810
114MAPK signaling pathway_Homo sapiens_hsa040100.52056461
115Olfactory transduction_Homo sapiens_hsa047400.49864069
116Serotonergic synapse_Homo sapiens_hsa047260.49521757
117Pyrimidine metabolism_Homo sapiens_hsa002400.48968676
118HTLV-I infection_Homo sapiens_hsa051660.48068392
119Insulin secretion_Homo sapiens_hsa049110.47838638
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46176246
121Herpes simplex infection_Homo sapiens_hsa051680.45627936
122Chemical carcinogenesis_Homo sapiens_hsa052040.45342854
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.44731087
124Purine metabolism_Homo sapiens_hsa002300.43909077
125Glioma_Homo sapiens_hsa052140.43274571
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41422554
127Glutamatergic synapse_Homo sapiens_hsa047240.39053648
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.39026846
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38135971
130Other glycan degradation_Homo sapiens_hsa005110.36845553
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.36239390
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35913322
133Wnt signaling pathway_Homo sapiens_hsa043100.35339152
134Inositol phosphate metabolism_Homo sapiens_hsa005620.35268695
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34330502
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33179817
137Melanoma_Homo sapiens_hsa052180.32857406
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32635430
139Sulfur relay system_Homo sapiens_hsa041220.31110869
140cAMP signaling pathway_Homo sapiens_hsa040240.30599746
141Pathways in cancer_Homo sapiens_hsa052000.29124611
142Shigellosis_Homo sapiens_hsa051310.28976088
143TNF signaling pathway_Homo sapiens_hsa046680.28924910
144Lysine degradation_Homo sapiens_hsa003100.27278568
145Mineral absorption_Homo sapiens_hsa049780.26156984
146Oxytocin signaling pathway_Homo sapiens_hsa049210.24892469
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.24438870
148Hedgehog signaling pathway_Homo sapiens_hsa043400.24374128
149Fatty acid metabolism_Homo sapiens_hsa012120.23599413
150Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22668923
151AMPK signaling pathway_Homo sapiens_hsa041520.22253012
152Tight junction_Homo sapiens_hsa045300.21738057
153Arginine and proline metabolism_Homo sapiens_hsa003300.20899785
154Sphingolipid metabolism_Homo sapiens_hsa006000.20387689
155Type I diabetes mellitus_Homo sapiens_hsa049400.18016618
156Basal cell carcinoma_Homo sapiens_hsa052170.17919815
157Morphine addiction_Homo sapiens_hsa050320.17248176
158N-Glycan biosynthesis_Homo sapiens_hsa005100.16779625
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16545495
160Vitamin digestion and absorption_Homo sapiens_hsa049770.15510654
161Epstein-Barr virus infection_Homo sapiens_hsa051690.15069730
162Rap1 signaling pathway_Homo sapiens_hsa040150.14285083
163Platelet activation_Homo sapiens_hsa046110.13726812
164Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13511394
165Viral carcinogenesis_Homo sapiens_hsa052030.11698388

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