TRIM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.96970846
2ensheathment of neurons (GO:0007272)6.37034329
3axon ensheathment (GO:0008366)6.37034329
4myelination (GO:0042552)6.28027770
5long-chain fatty acid biosynthetic process (GO:0042759)6.08274908
6negative regulation of neurotransmitter secretion (GO:0046929)5.33066703
7negative regulation of neurotransmitter transport (GO:0051589)5.00996770
8myelin maintenance (GO:0043217)4.73232004
9response to interferon-beta (GO:0035456)4.57194487
10type I interferon signaling pathway (GO:0060337)4.54266301
11cellular response to type I interferon (GO:0071357)4.54266301
12regulation of collateral sprouting (GO:0048670)4.49283006
13response to type I interferon (GO:0034340)4.48533922
14response to interferon-alpha (GO:0035455)4.48395278
15negative regulation of viral genome replication (GO:0045071)4.44789391
16oligodendrocyte differentiation (GO:0048709)4.40176369
17cholesterol biosynthetic process (GO:0006695)4.22863194
18L-amino acid import (GO:0043092)4.22241029
19neutrophil activation involved in immune response (GO:0002283)4.21800730
20regulation of interferon-alpha production (GO:0032647)4.19910561
21import into cell (GO:0098657)4.17612129
22response to methylmercury (GO:0051597)4.13361972
23negative regulation of protein localization to cell surface (GO:2000009)4.10035346
24presynaptic membrane organization (GO:0097090)4.09507737
25positive regulation of interferon-alpha production (GO:0032727)4.09380085
26positive regulation of oligodendrocyte differentiation (GO:0048714)4.06415658
27isoprenoid biosynthetic process (GO:0008299)4.01070194
28limb bud formation (GO:0060174)4.00227737
29creatine metabolic process (GO:0006600)3.93161304
30glycerophospholipid catabolic process (GO:0046475)3.91342260
31presynaptic membrane assembly (GO:0097105)3.83793459
32photoreceptor cell differentiation (GO:0046530)3.77584720
33eye photoreceptor cell differentiation (GO:0001754)3.77584720
34establishment of mitochondrion localization (GO:0051654)3.76573933
35sterol biosynthetic process (GO:0016126)3.70000804
36neuron remodeling (GO:0016322)3.67109048
37cellular response to interferon-alpha (GO:0035457)3.53891454
38peptidyl-tyrosine autophosphorylation (GO:0038083)3.52355963
39amyloid precursor protein metabolic process (GO:0042982)3.52007573
40astrocyte development (GO:0014002)3.51774781
41rRNA catabolic process (GO:0016075)3.46760088
42negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.46165324
43asymmetric protein localization (GO:0008105)3.45629804
44platelet dense granule organization (GO:0060155)3.43732013
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.42047083
46organ growth (GO:0035265)3.41549345
47response to lipoprotein particle (GO:0055094)3.37046051
48protein palmitoylation (GO:0018345)3.34731876
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33952527
50regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.32496160
51regulation of T-helper 1 cell differentiation (GO:0045625)3.30871457
52GPI anchor biosynthetic process (GO:0006506)3.30835110
53DNA deamination (GO:0045006)3.29691639
54cerebral cortex radially oriented cell migration (GO:0021799)3.29427141
55regulation of interferon-beta biosynthetic process (GO:0045357)3.29273194
56apical protein localization (GO:0045176)3.26483001
57* negative regulation of viral process (GO:0048525)3.24565275
58negative regulation of execution phase of apoptosis (GO:1900118)3.24416785
59substantia nigra development (GO:0021762)3.24003249
60phosphatidylinositol acyl-chain remodeling (GO:0036149)3.22019405
61sphingosine metabolic process (GO:0006670)3.21732289
62cellular response to interferon-beta (GO:0035458)3.21619684
63GPI anchor metabolic process (GO:0006505)3.16853843
64positive regulation of interferon-beta production (GO:0032728)3.14768018
65long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.12907038
66regulation of viral genome replication (GO:0045069)3.12306424
67macrophage activation involved in immune response (GO:0002281)3.11182274
68response to redox state (GO:0051775)3.10921787
69replicative senescence (GO:0090399)3.10682795
70indole-containing compound catabolic process (GO:0042436)3.08306610
71indolalkylamine catabolic process (GO:0046218)3.08306610
72tryptophan catabolic process (GO:0006569)3.08306610
73regulation of interleukin-8 secretion (GO:2000482)3.07858802
74long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.05995263
75neuron cell-cell adhesion (GO:0007158)3.03506117
76magnesium ion transport (GO:0015693)3.03487492
77amino acid import (GO:0043090)3.03109493
78immunoglobulin mediated immune response (GO:0016064)3.02136459
79response to nitrosative stress (GO:0051409)3.01604548
80regulation of lipoprotein metabolic process (GO:0050746)3.01120881
81* defense response to virus (GO:0051607)2.98583513
82tryptophan metabolic process (GO:0006568)2.96843806
83positive regulation of cellular amine metabolic process (GO:0033240)2.96608605
84positive regulation of action potential (GO:0045760)2.95974944
85* negative regulation of viral entry into host cell (GO:0046597)2.94368053
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93434467
87leukocyte migration involved in inflammatory response (GO:0002523)2.93121011
88cellular response to epinephrine stimulus (GO:0071872)2.90978472
89regulation of RIG-I signaling pathway (GO:0039535)2.90586682
90nucleotide transmembrane transport (GO:1901679)2.90428029
91histone H2B ubiquitination (GO:0033523)2.89403170
92cellular response to exogenous dsRNA (GO:0071360)2.85305753
93adult walking behavior (GO:0007628)2.84952058
94axon development (GO:0061564)2.83629096
95membrane tubulation (GO:0097320)2.82213373
96B cell mediated immunity (GO:0019724)2.80416815
97preassembly of GPI anchor in ER membrane (GO:0016254)2.79097734
98adhesion of symbiont to host cell (GO:0044650)2.76975791
99virion attachment to host cell (GO:0019062)2.76975791
100regulation of pigment cell differentiation (GO:0050932)2.75701005
101positive regulation of glial cell differentiation (GO:0045687)2.75483602
102myelination in peripheral nervous system (GO:0022011)2.75427062
103peripheral nervous system axon ensheathment (GO:0032292)2.75427062
104kynurenine metabolic process (GO:0070189)2.73732507
105positive regulation of natural killer cell differentiation (GO:0032825)2.73192342
106mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72024814
107mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72024814
108negative regulation of axonogenesis (GO:0050771)2.71820804
109positive regulation of lymphocyte apoptotic process (GO:0070230)2.71636577
110lateral sprouting from an epithelium (GO:0060601)2.70858832
111regulation of MHC class I biosynthetic process (GO:0045343)2.70724269
112DNA strand renaturation (GO:0000733)2.68924322
113cranial nerve development (GO:0021545)2.67063431
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.66421044
115indolalkylamine metabolic process (GO:0006586)2.65885075
116interferon-gamma-mediated signaling pathway (GO:0060333)2.65479218
117amyloid precursor protein catabolic process (GO:0042987)2.65380557
118proteasome assembly (GO:0043248)2.63138428
119regulation of somitogenesis (GO:0014807)2.62759026
120very long-chain fatty acid metabolic process (GO:0000038)2.62654779
121phosphatidylserine acyl-chain remodeling (GO:0036150)2.62151038
122transmission of nerve impulse (GO:0019226)2.62078167
123fatty-acyl-CoA biosynthetic process (GO:0046949)2.60230501
124regulation of thymocyte apoptotic process (GO:0070243)2.60202982
125enteric nervous system development (GO:0048484)2.59967238
126fatty-acyl-CoA metabolic process (GO:0035337)2.59583404
127artery development (GO:0060840)2.58940576
128regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58823403
129* regulation of viral entry into host cell (GO:0046596)2.58805171
130positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58317055
131glial cell development (GO:0021782)2.57659422
132positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.57469810
133sphingoid metabolic process (GO:0046519)2.56778680
134negative regulation of axon extension (GO:0030517)2.56733092
135neurotransmitter uptake (GO:0001504)2.56591121
136response to xenobiotic stimulus (GO:0009410)2.54989521
137positive regulation of gliogenesis (GO:0014015)2.54751379
138polyol transport (GO:0015791)2.54320105
139glial cell differentiation (GO:0010001)2.54249646
140response to epinephrine (GO:0071871)2.53616397
141negative regulation of exocytosis (GO:0045920)2.53462916
142regulation of interleukin-13 production (GO:0032656)2.52780381
143neuronal action potential propagation (GO:0019227)2.51429456
144positive regulation of NF-kappaB import into nucleus (GO:0042346)2.51199924
145diol metabolic process (GO:0034311)2.50361794
146dopamine biosynthetic process (GO:0042416)2.48611228
147positive regulation of interleukin-17 production (GO:0032740)2.48501667
148cyclic nucleotide catabolic process (GO:0009214)2.48449256
149double-strand break repair via homologous recombination (GO:0000724)2.47792620
150regulation of T-helper 1 type immune response (GO:0002825)2.46247992
151neuronal ion channel clustering (GO:0045161)2.45987622
152neutrophil activation (GO:0042119)2.45005806
153recombinational repair (GO:0000725)2.44173928
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43700930
155replication fork processing (GO:0031297)2.43302786
156response to protozoan (GO:0001562)2.43240960
157somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.42450871
158somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.42450871
159isotype switching (GO:0045190)2.42450871
160positive regulation of T cell apoptotic process (GO:0070234)2.41099279
161positive regulation of T-helper 1 type immune response (GO:0002827)2.39861087
162substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.39800298
163substrate-independent telencephalic tangential migration (GO:0021826)2.39800298
164positive regulation by symbiont of host defense response (GO:0052509)2.39709901
165modulation by symbiont of host defense response (GO:0052031)2.39709901
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39709901
167modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39709901
168positive regulation by organism of defense response of other organism involved in symbiotic interact2.39709901
169modulation by symbiont of host immune response (GO:0052553)2.39709901
170positive regulation of toll-like receptor signaling pathway (GO:0034123)2.39642449
171regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38864756
172cytidine deamination (GO:0009972)2.38052843
173cytidine metabolic process (GO:0046087)2.38052843
174cytidine catabolic process (GO:0006216)2.38052843
175short-term memory (GO:0007614)2.37554237
176negative regulation of interleukin-10 production (GO:0032693)2.37249356
177regulation of antigen processing and presentation (GO:0002577)2.37084009
178positive regulation of leukocyte apoptotic process (GO:2000108)2.36729583
179regulation of interferon-beta production (GO:0032648)2.36574610
180glycosylceramide metabolic process (GO:0006677)2.36089759
181retina layer formation (GO:0010842)2.36059383
182positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.36055364
183microtubule polymerization or depolymerization (GO:0031109)2.35796812
184positive regulation of interleukin-1 beta secretion (GO:0050718)2.35095467
185positive regulation of interleukin-8 secretion (GO:2000484)2.33471884
186negative regulation of viral transcription (GO:0032897)2.30929046
187positive regulation of defense response to virus by host (GO:0002230)2.27982963
188antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.27019703
189negative regulation of alpha-beta T cell differentiation (GO:0046639)2.26730937
190defense response to protozoan (GO:0042832)2.26476838
191granulocyte activation (GO:0036230)2.26166378
192regulation of meiosis I (GO:0060631)2.25459425
193regulation of defense response to virus by host (GO:0050691)2.25073499
194regulation of cytokine secretion involved in immune response (GO:0002739)2.24571296
195water-soluble vitamin biosynthetic process (GO:0042364)2.23164506
196natural killer cell activation involved in immune response (GO:0002323)2.22798423
197regulation of interleukin-1 beta secretion (GO:0050706)2.21961102
198axon ensheathment in central nervous system (GO:0032291)11.3013860
199central nervous system myelination (GO:0022010)11.3013860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.25034389
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.43300908
3GBX2_23144817_ChIP-Seq_PC3_Human3.12939297
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95855114
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.95105650
6EZH2_22144423_ChIP-Seq_EOC_Human2.71971649
7ZNF274_21170338_ChIP-Seq_K562_Hela2.67324404
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.55281909
9TAF15_26573619_Chip-Seq_HEK293_Human2.54416656
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47558093
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41921199
12ELK1_19687146_ChIP-ChIP_HELA_Human2.37656848
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37399314
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31533434
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30451620
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.26632418
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20397685
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.20039821
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.12921729
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.12582866
21AR_21572438_ChIP-Seq_LNCaP_Human2.10167596
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07968246
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07816130
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07410052
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07410052
26EWS_26573619_Chip-Seq_HEK293_Human2.01166611
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99876559
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98517313
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94897693
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.88565685
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88086574
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82524354
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82151751
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81308086
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.77274285
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77197421
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77105252
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75531151
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75368859
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.74900809
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73879690
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72358031
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72004465
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71751990
45VDR_22108803_ChIP-Seq_LS180_Human1.70243466
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67425206
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67182077
48ER_23166858_ChIP-Seq_MCF-7_Human1.62329347
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.61519216
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.60405878
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58576204
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.53880202
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52987678
54GATA1_22025678_ChIP-Seq_K562_Human1.52895842
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52437319
56IRF1_19129219_ChIP-ChIP_H3396_Human1.52308735
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51980123
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48542383
59P300_19829295_ChIP-Seq_ESCs_Human1.46738710
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.46296437
61CDX2_22108803_ChIP-Seq_LS180_Human1.43178779
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42217936
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42058449
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.41748708
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41747166
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.39260786
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39233507
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37223493
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.37036287
70BRD4_25478319_ChIP-Seq_HGPS_Human1.36549858
71FUS_26573619_Chip-Seq_HEK293_Human1.35915567
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34913262
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34521556
74CJUN_26792858_Chip-Seq_BT549_Human1.34484553
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.34481064
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.33889916
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.33794587
78* GATA3_26560356_Chip-Seq_TH2_Human1.33156532
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32596594
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32233767
81BCAT_22108803_ChIP-Seq_LS180_Human1.32057328
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31444276
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30800864
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.30672398
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28441303
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27959202
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27872102
88RNF2_27304074_Chip-Seq_NSC_Mouse1.27839150
89P300_18555785_Chip-Seq_ESCs_Mouse1.27609135
90DROSHA_22980978_ChIP-Seq_HELA_Human1.26910117
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24965421
92VDR_23849224_ChIP-Seq_CD4+_Human1.24327916
93VDR_24787735_ChIP-Seq_THP-1_Human1.22817393
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22433357
95SALL4_22934838_ChIP-ChIP_CD34+_Human1.22337923
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22208172
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.21884019
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.21491122
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21320204
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20718709
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20683630
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20642309
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20053613
104NANOG_19829295_ChIP-Seq_ESCs_Human1.19639727
105SOX2_19829295_ChIP-Seq_ESCs_Human1.19639727
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18458318
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17829233
108SPI1_23547873_ChIP-Seq_NB4_Human1.17677302
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16815709
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16706510
111E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16314490
112P53_22387025_ChIP-Seq_ESCs_Mouse1.15664229
113HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15532051
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.15357863
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14851323
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14806301
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.14135964
118RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13702568
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12833853
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10246287
121CBP_20019798_ChIP-Seq_JUKART_Human1.10246287
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.08950925
123TCF4_22108803_ChIP-Seq_LS180_Human1.08403364
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07940988
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07881481
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.07433713
127KLF4_18555785_Chip-Seq_ESCs_Mouse1.07373105
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07025771
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06719798
130SOX2_18555785_Chip-Seq_ESCs_Mouse1.04621481
131TP53_16413492_ChIP-PET_HCT116_Human1.04590557
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.04585743
133STAT3_23295773_ChIP-Seq_U87_Human1.04472324
134SMAD4_21799915_ChIP-Seq_A2780_Human1.03938632
135* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03035278
136SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02731351
137KDM2B_26808549_Chip-Seq_REH_Human1.02676625
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02506511
139IGF1R_20145208_ChIP-Seq_DFB_Human1.02392627
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.01934592
141MYB_26560356_Chip-Seq_TH2_Human1.01010671
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00619796
143TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00588790
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00446368
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00431810
146NMYC_18555785_Chip-Seq_ESCs_Mouse0.99925556
147AHR_22903824_ChIP-Seq_MCF-7_Human0.99620477
148TP53_18474530_ChIP-ChIP_U2OS_Human0.99415118
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99292131
150* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98871522
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.98739777
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98739777
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98207255
154NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98207255
155AR_25329375_ChIP-Seq_VCAP_Human0.97668615
156KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96997409
157AR_20517297_ChIP-Seq_VCAP_Human0.96616601
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.96523073
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95086151
160TCF4_23295773_ChIP-Seq_U87_Human0.95044620
161P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94891792
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93821299
163SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93449637
164SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92857091
165MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92699631
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91726906
167FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91459933
168STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89646733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage7.22440949
2MP0000920_abnormal_myelination5.07504266
3MP0003136_yellow_coat_color4.14846585
4MP0003880_abnormal_central_pattern3.57617479
5MP0002138_abnormal_hepatobiliary_system3.45693247
6MP0009697_abnormal_copulation3.43539443
7MP0005409_darkened_coat_color3.26695175
8MP0004381_abnormal_hair_follicle3.19190408
9MP0003950_abnormal_plasma_membrane3.10773484
10MP0001835_abnormal_antigen_presentation3.00197298
11MP0004742_abnormal_vestibular_system2.80231349
12MP0005171_absent_coat_pigmentation2.74104900
13MP0009785_altered_susceptibility_to2.67819507
14MP0003690_abnormal_glial_cell2.60550143
15MP0008260_abnormal_autophagy2.44631758
16MP0004270_analgesia2.42745130
17MP0001486_abnormal_startle_reflex2.39024269
18MP0004885_abnormal_endolymph2.35935792
19MP0001905_abnormal_dopamine_level2.31965772
20MP0002254_reproductive_system_inflammat2.26244984
21MP0002148_abnormal_hypersensitivity_rea2.19661240
22MP0002272_abnormal_nervous_system2.18488961
23MP0000685_abnormal_immune_system2.16707296
24MP0001529_abnormal_vocalization2.11879283
25MP0004142_abnormal_muscle_tone2.05839569
26MP0002102_abnormal_ear_morphology2.02346550
27MP0005451_abnormal_body_composition1.91789661
28MP0005084_abnormal_gallbladder_morpholo1.90409176
29MP0003634_abnormal_glial_cell1.89731917
30MP0005423_abnormal_somatic_nervous1.87549383
31MP0001661_extended_life_span1.86501643
32MP0001485_abnormal_pinna_reflex1.85684619
33MP0009764_decreased_sensitivity_to1.83437035
34MP0000383_abnormal_hair_follicle1.80239864
35MP0002064_seizures1.78832170
36MP0000569_abnormal_digit_pigmentation1.78782653
37MP0003329_amyloid_beta_deposits1.78207749
38MP0000778_abnormal_nervous_system1.78131501
39MP0004134_abnormal_chest_morphology1.74114520
40MP0000566_synostosis1.72515680
41MP0010678_abnormal_skin_adnexa1.67788053
42MP0002229_neurodegeneration1.65079491
43MP0005671_abnormal_response_to1.64738240
44MP0001800_abnormal_humoral_immune1.64075857
45MP0003252_abnormal_bile_duct1.58808483
46MP0003303_peritoneal_inflammation1.58758640
47MP0003806_abnormal_nucleotide_metabolis1.58497304
48MP0002452_abnormal_antigen_presenting1.57540632
49MP0000372_irregular_coat_pigmentation1.56677310
50MP0005410_abnormal_fertilization1.56389848
51MP0001188_hyperpigmentation1.52613140
52MP0009046_muscle_twitch1.51444454
53MP0002723_abnormal_immune_serum1.51282533
54MP0009745_abnormal_behavioral_response1.51163085
55MP0005000_abnormal_immune_tolerance1.50080130
56MP0000462_abnormal_digestive_system1.49664332
57MP0005025_abnormal_response_to1.47293321
58MP0003436_decreased_susceptibility_to1.46064495
59MP0001963_abnormal_hearing_physiology1.44689942
60MP0005551_abnormal_eye_electrophysiolog1.42154726
61MP0002419_abnormal_innate_immunity1.41795095
62MP0004272_abnormal_basement_membrane1.39988985
63MP0003632_abnormal_nervous_system1.37083357
64MP0003300_gastrointestinal_ulcer1.33785491
65MP0002168_other_aberrant_phenotype1.30438621
66MP0003938_abnormal_ear_development1.28878226
67MP0001440_abnormal_grooming_behavior1.25752784
68MP0002734_abnormal_mechanical_nocicepti1.25641605
69MP0008877_abnormal_DNA_methylation1.25499914
70MP0001346_abnormal_lacrimal_gland1.22889870
71MP0001851_eye_inflammation1.22269227
72MP0002396_abnormal_hematopoietic_system1.22202185
73MP0003635_abnormal_synaptic_transmissio1.21158289
74MP0004859_abnormal_synaptic_plasticity1.20760522
75MP0003186_abnormal_redox_activity1.20056092
76MP0004147_increased_porphyrin_level1.19013049
77MP0005248_abnormal_Harderian_gland1.18633078
78MP0001819_abnormal_immune_cell1.18207418
79MP0010368_abnormal_lymphatic_system1.18149986
80MP0002420_abnormal_adaptive_immunity1.17545180
81MP0001915_intracranial_hemorrhage1.17239296
82MP0000026_abnormal_inner_ear1.17074522
83MP0002006_tumorigenesis1.16913798
84MP0000762_abnormal_tongue_morphology1.15505754
85MP0001986_abnormal_taste_sensitivity1.14103729
86MP0002752_abnormal_somatic_nervous1.13294602
87MP0005167_abnormal_blood-brain_barrier1.13122821
88MP0003631_nervous_system_phenotype1.12623837
89MP0001970_abnormal_pain_threshold1.12145181
90MP0002282_abnormal_trachea_morphology1.10132476
91MP0002572_abnormal_emotion/affect_behav1.09897139
92MP0002882_abnormal_neuron_morphology1.09527429
93MP0002067_abnormal_sensory_capabilities1.08784226
94MP0001845_abnormal_inflammatory_respons1.07460766
95MP0008569_lethality_at_weaning1.06594151
96MP0005174_abnormal_tail_pigmentation1.05699486
97MP0006082_CNS_inflammation1.05511971
98MP0003448_altered_tumor_morphology1.04396463
99MP0008469_abnormal_protein_level1.04396076
100MP0001293_anophthalmia1.03419151
101MP0005395_other_phenotype1.03064732
102MP0000465_gastrointestinal_hemorrhage1.01717033
103MP0002132_abnormal_respiratory_system1.01659531
104MP0005360_urolithiasis1.01582298
105MP0005195_abnormal_posterior_eye1.01572989
106MP0000955_abnormal_spinal_cord1.01236361
107MP0003633_abnormal_nervous_system0.99294327
108MP0001533_abnormal_skeleton_physiology0.99026615
109MP0010386_abnormal_urinary_bladder0.98753445
110MP0005085_abnormal_gallbladder_physiolo0.98534403
111MP0005164_abnormal_response_to0.98320023
112MP0004883_abnormal_blood_vessel0.97118785
113MP0002066_abnormal_motor_capabilities/c0.96795056
114MP0003937_abnormal_limbs/digits/tail_de0.96643661
115MP0000427_abnormal_hair_cycle0.96213882
116MP0002735_abnormal_chemical_nociception0.95270450
117MP0001879_abnormal_lymphatic_vessel0.94963402
118MP0000689_abnormal_spleen_morphology0.94925768
119MP0000647_abnormal_sebaceous_gland0.94864295
120MP0002405_respiratory_system_inflammati0.93607955
121MP0001968_abnormal_touch/_nociception0.93274967
122MP0005464_abnormal_platelet_physiology0.92906424
123MP0000604_amyloidosis0.92799693
124MP0005595_abnormal_vascular_smooth0.91772749
125MP0001348_abnormal_lacrimal_gland0.91023507
126MP0003045_fibrosis0.90511423
127MP0002166_altered_tumor_susceptibility0.90318032
128MP0003724_increased_susceptibility_to0.89613804
129MP0005397_hematopoietic_system_phenotyp0.89047962
130MP0001545_abnormal_hematopoietic_system0.89047962
131MP0004043_abnormal_pH_regulation0.88185817
132MP0008438_abnormal_cutaneous_collagen0.87841237
133MP0000579_abnormal_nail_morphology0.87129112
134MP0000015_abnormal_ear_pigmentation0.86801801
135MP0000716_abnormal_immune_system0.85850915
136MP0008057_abnormal_DNA_replication0.85373358
137MP0002398_abnormal_bone_marrow0.84890263
138MP0009053_abnormal_anal_canal0.83814167
139MP0009250_abnormal_appendicular_skeleto0.83196321
140MP0001324_abnormal_eye_pigmentation0.82511592
141MP0000631_abnormal_neuroendocrine_gland0.82090573
142MP0006292_abnormal_olfactory_placode0.82007620
143MP0009379_abnormal_foot_pigmentation0.80883994
144MP0001727_abnormal_embryo_implantation0.79814910
145MP0006072_abnormal_retinal_apoptosis0.79443177
146MP0002733_abnormal_thermal_nociception0.78349058
147MP0005379_endocrine/exocrine_gland_phen0.77012539
148MP0002063_abnormal_learning/memory/cond0.76875300
149MP0003195_calcinosis0.75790108
150MP0005386_behavior/neurological_phenoty0.75202700
151MP0004924_abnormal_behavior0.75202700
152MP0002938_white_spotting0.75183268
153MP0005253_abnormal_eye_physiology0.74603469
154MP0000371_diluted_coat_color0.74590093
155MP0003943_abnormal_hepatobiliary_system0.73791204
156MP0001790_abnormal_immune_system0.73547051
157MP0005387_immune_system_phenotype0.73547051
158MP0000467_abnormal_esophagus_morphology0.73274502
159MP0005023_abnormal_wound_healing0.72690231
160MP0002429_abnormal_blood_cell0.72641880
161MP0003941_abnormal_skin_development0.72582511
162MP0010094_abnormal_chromosome_stability0.72562656
163MP0005310_abnormal_salivary_gland0.71113293
164MP0002277_abnormal_respiratory_mucosa0.71051355
165MP0000613_abnormal_salivary_gland0.70840317
166MP0002653_abnormal_ependyma_morphology0.70785841
167MP0000343_altered_response_to0.69627266
168MP0010155_abnormal_intestine_physiology0.69285667
169MP0002928_abnormal_bile_duct0.69234471
170MP0005058_abnormal_lysosome_morphology0.69191135
171MP0002933_joint_inflammation0.69069180
172MP0002722_abnormal_immune_system0.68816204
173MP0005408_hypopigmentation0.67937390
174MP0004808_abnormal_hematopoietic_stem0.67551257
175MP0003718_maternal_effect0.67508979
176MP0002295_abnormal_pulmonary_circulatio0.67144330
177MP0002736_abnormal_nociception_after0.66690400
178MP0008058_abnormal_DNA_repair0.66202729
179MP0001119_abnormal_female_reproductive0.65920013
180MP0001340_abnormal_eyelid_morphology0.65773604
181MP0001664_abnormal_digestion0.65580667
182MP0009763_increased_sensitivity_to0.65484677
183MP0001299_abnormal_eye_distance/0.64534769
184MP0005220_abnormal_exocrine_pancreas0.64095773
185MP0005075_abnormal_melanosome_morpholog0.63752916
186MP0003279_aneurysm0.63428085

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.13261573
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.13261573
3Neurofibrillary tangles (HP:0002185)5.28940362
4Parakeratosis (HP:0001036)5.02998367
5Agnosia (HP:0010524)4.41536600
6Peripheral hypomyelination (HP:0007182)4.40856360
7Abnormality of the corticospinal tract (HP:0002492)4.34014833
8Sensory axonal neuropathy (HP:0003390)4.10911189
9Onion bulb formation (HP:0003383)3.96035866
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.68784066
11Absent septum pellucidum (HP:0001331)3.66096562
12Cerebral inclusion bodies (HP:0100314)3.53916415
13Septo-optic dysplasia (HP:0100842)3.42405706
14Alacrima (HP:0000522)3.35501476
15Pancreatic cysts (HP:0001737)3.28365606
16White forelock (HP:0002211)3.26628519
17Patchy hypopigmentation of hair (HP:0011365)3.23195931
18Abnormality of the septum pellucidum (HP:0007375)3.17774199
19Optic neuritis (HP:0100653)3.11207914
20Retrobulbar optic neuritis (HP:0100654)3.11207914
21True hermaphroditism (HP:0010459)3.02472409
22Disinhibition (HP:0000734)2.95341706
23Spastic gait (HP:0002064)2.92901212
24Pancreatic fibrosis (HP:0100732)2.91846351
25Fibular aplasia (HP:0002990)2.88068661
26Slow saccadic eye movements (HP:0000514)2.86694967
27Retinal dysplasia (HP:0007973)2.85151987
28Orchitis (HP:0100796)2.84873911
29Cerebral hypomyelination (HP:0006808)2.83525670
30Delayed closure of the anterior fontanelle (HP:0001476)2.82848167
31Abnormal auditory evoked potentials (HP:0006958)2.80259487
32Prolonged neonatal jaundice (HP:0006579)2.76010407
33Colon cancer (HP:0003003)2.73164145
34Hypoplasia of the uterus (HP:0000013)2.72173614
35Recurrent bacterial skin infections (HP:0005406)2.71681979
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70844165
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.70093825
38Hypoplasia of the fovea (HP:0007750)2.70093825
39Supranuclear gaze palsy (HP:0000605)2.68877707
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68641940
41Segmental peripheral demyelination/remyelination (HP:0003481)2.61830916
42Partial duplication of thumb phalanx (HP:0009944)2.61732979
43Chronic hepatic failure (HP:0100626)2.61631550
44Fibular hypoplasia (HP:0003038)2.59768311
45Anteriorly placed anus (HP:0001545)2.59187874
46Decreased lacrimation (HP:0000633)2.59086503
47Congenital ichthyosiform erythroderma (HP:0007431)2.58267934
48Amyotrophic lateral sclerosis (HP:0007354)2.58111604
49Dysmetria (HP:0001310)2.55605756
50Hematochezia (HP:0002573)2.54191240
51Hypophosphatemic rickets (HP:0004912)2.50784558
52Absent/shortened dynein arms (HP:0200106)2.49876122
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.49876122
54Chin dimple (HP:0010751)2.49743566
55Decreased central vision (HP:0007663)2.49373582
56Hypoplasia of the iris (HP:0007676)2.45692151
57Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.45254975
58Metabolic alkalosis (HP:0200114)2.43292466
59Increased IgM level (HP:0003496)2.43143127
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.42039968
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.39477140
62Abnormality of midbrain morphology (HP:0002418)2.39394537
63Molar tooth sign on MRI (HP:0002419)2.39394537
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.39150718
65Hepatosplenomegaly (HP:0001433)2.38680658
66Myositis (HP:0100614)2.38150056
67Abnormality of the fovea (HP:0000493)2.37954908
68Leukodystrophy (HP:0002415)2.37905603
69Thickened helices (HP:0000391)2.37293584
70Insidious onset (HP:0003587)2.36221299
71Termporal pattern (HP:0011008)2.36221299
72Asymmetry of the thorax (HP:0001555)2.33968210
73Hypomagnesemia (HP:0002917)2.33698003
74Cupped ear (HP:0000378)2.33125237
75Disproportionate short-trunk short stature (HP:0003521)2.32965258
76Partial agenesis of the corpus callosum (HP:0001338)2.31539107
77Conical tooth (HP:0000698)2.29981820
78Morphological abnormality of the inner ear (HP:0011390)2.29976802
79Scanning speech (HP:0002168)2.29289130
80Abnormal biliary tract physiology (HP:0012439)2.29052582
81Bile duct proliferation (HP:0001408)2.29052582
82Spastic paraparesis (HP:0002313)2.26765498
83Intention tremor (HP:0002080)2.26037222
84Prostate neoplasm (HP:0100787)2.25194711
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25007360
86Poor head control (HP:0002421)2.23184547
87Hypoplastic pelvis (HP:0008839)2.22711271
88Encephalitis (HP:0002383)2.22158872
89Premature skin wrinkling (HP:0100678)2.20795653
90Attenuation of retinal blood vessels (HP:0007843)2.19004240
91Recurrent abscess formation (HP:0002722)2.16332226
92Partial duplication of the phalanx of hand (HP:0009999)2.16238961
93Ankle clonus (HP:0011448)2.16000607
94Elevated erythrocyte sedimentation rate (HP:0003565)2.14841770
95Nasolacrimal duct obstruction (HP:0000579)2.14091507
96Duplicated collecting system (HP:0000081)2.09069326
97Autoamputation (HP:0001218)2.07938250
98Clumsiness (HP:0002312)2.07701150
99Keratoconjunctivitis (HP:0001096)2.07433443
100Methylmalonic acidemia (HP:0002912)2.07285787
101Humeroradial synostosis (HP:0003041)2.07072275
102Synostosis involving the elbow (HP:0003938)2.07072275
103Abnormality of T cell number (HP:0011839)2.05869615
104Hemoptysis (HP:0002105)2.05556484
105Chronic sinusitis (HP:0011109)2.04964143
106Akinesia (HP:0002304)2.03670747
107Keratoconjunctivitis sicca (HP:0001097)2.03568516
108Increased circulating renin level (HP:0000848)2.03429607
109Stomach cancer (HP:0012126)2.02882048
110Recurrent cutaneous fungal infections (HP:0011370)2.01791342
111Chronic mucocutaneous candidiasis (HP:0002728)2.01791342
112Stridor (HP:0010307)2.01710090
113Aplasia/hypoplasia of the uterus (HP:0008684)1.97937274
114Aortic aneurysm (HP:0004942)1.97428943
115Mixed hearing impairment (HP:0000410)1.96729938
116Esophageal atresia (HP:0002032)1.96553146
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.95692092
118Pulmonary infiltrates (HP:0002113)1.94064915
119Split foot (HP:0001839)1.93737639
120Overfolded helix (HP:0000396)1.93021225
121Erythroderma (HP:0001019)1.92042203
122Anomalous pulmonary venous return (HP:0010772)1.91960733
123Capillary hemangiomas (HP:0005306)1.91790560
124Aplasia involving bones of the upper limbs (HP:0009823)1.90759012
125Aplasia of the phalanges of the hand (HP:0009802)1.90759012
126Aplasia involving bones of the extremities (HP:0009825)1.90759012
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90200377
128Hypochromic microcytic anemia (HP:0004840)1.89851922
129Albinism (HP:0001022)1.89832211
130Peritonitis (HP:0002586)1.89800523
131Increased serum pyruvate (HP:0003542)1.89776071
132Abnormality of glycolysis (HP:0004366)1.89776071
133Panhypogammaglobulinemia (HP:0003139)1.87844400
134Duplication of thumb phalanx (HP:0009942)1.86382783
135Recurrent skin infections (HP:0001581)1.85837606
136Fused cervical vertebrae (HP:0002949)1.84648679
137Congenital hepatic fibrosis (HP:0002612)1.84577076
138Asplenia (HP:0001746)1.84340718
139Abnormal ciliary motility (HP:0012262)1.84150279
140Abnormality of chromosome stability (HP:0003220)1.84025026
141Hypokalemic alkalosis (HP:0001949)1.83754801
142Bifid tongue (HP:0010297)1.82814303
143Cerebral hemorrhage (HP:0001342)1.81547437
144Cystic liver disease (HP:0006706)1.81181078
145CNS hypomyelination (HP:0003429)1.80048243
146Nephronophthisis (HP:0000090)1.79925805
147Abnormally folded helix (HP:0008544)1.79449902
148Bilateral microphthalmos (HP:0007633)1.78952235
149Abolished electroretinogram (ERG) (HP:0000550)1.78371227
150Broad ribs (HP:0000885)1.78305663
151Abnormality of B cell number (HP:0010975)1.78220651
152Inappropriate behavior (HP:0000719)1.78070340
153Neoplasm of the adrenal cortex (HP:0100641)1.77854725
154Decreased motor nerve conduction velocity (HP:0003431)1.77682148
155T lymphocytopenia (HP:0005403)1.77491885
156Abnormality of the pulmonary veins (HP:0011718)1.75740460
157Vasculitis (HP:0002633)1.75693081
158Renal Fanconi syndrome (HP:0001994)1.75201737
159Foot dorsiflexor weakness (HP:0009027)1.75160938
160Recurrent fungal infections (HP:0002841)1.74454366
161Aplasia cutis congenita (HP:0001057)1.73883581
162Myokymia (HP:0002411)1.72799295
163Xerostomia (HP:0000217)1.72326933
164Atrophy/Degeneration involving motor neurons (HP:0007373)1.71786458
165Upper motor neuron abnormality (HP:0002127)1.71578868
166Congenital sensorineural hearing impairment (HP:0008527)1.71287152
167Increased corneal curvature (HP:0100692)1.71065910
168Keratoconus (HP:0000563)1.71065910
169Axonal loss (HP:0003447)1.70973704
170Abnormality of the renal medulla (HP:0100957)1.69961382
1713-Methylglutaconic aciduria (HP:0003535)1.69906024
172Porencephaly (HP:0002132)1.69524939
173Stomatitis (HP:0010280)1.69232543
174Optic nerve hypoplasia (HP:0000609)1.69084608
175Hypoproteinemia (HP:0003075)1.69007485
176Abnormality of T cells (HP:0002843)1.68934139
177Aplasia/Hypoplasia of the uvula (HP:0010293)1.68403810
178Abnormality of the renal collecting system (HP:0004742)1.68115484
179Chronic otitis media (HP:0000389)1.68071044
180Recurrent viral infections (HP:0004429)1.67662490
181Paraparesis (HP:0002385)1.67478578
182Poor speech (HP:0002465)1.67453960
183Abnormality of magnesium homeostasis (HP:0004921)1.66683869
184Bowel incontinence (HP:0002607)1.66137620
185Abnormality of T cell physiology (HP:0011840)1.66129441
186Choroideremia (HP:0001139)1.65935816
187Aplasia/Hypoplasia of the macula (HP:0008059)1.65623198
188Agammaglobulinemia (HP:0004432)1.65274151
189Recurrent bronchitis (HP:0002837)1.64569352
190Anal atresia (HP:0002023)1.64241240
191Anencephaly (HP:0002323)1.63176634
192Amaurosis fugax (HP:0100576)1.63012099
193Intrahepatic cholestasis (HP:0001406)1.62616539
194Vacuolated lymphocytes (HP:0001922)1.61583451
195Natal tooth (HP:0000695)1.61019101
196Leukocytosis (HP:0001974)1.60649148
197Meckel diverticulum (HP:0002245)1.60492206
198Abnormality of the prostate (HP:0008775)1.60187206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.69986843
2NUAK13.91786276
3OXSR13.79602944
4PKN13.20345802
5TAF12.96619574
6EPHB12.94936067
7BLK2.85122872
8TIE12.79487986
9EIF2AK12.77374506
10ZAK2.73415134
11VRK22.70450844
12FRK2.60239059
13CASK2.53097683
14MAP4K22.35434719
15MAPKAPK52.33180885
16PBK2.22902093
17WNK42.18672984
18TNIK2.17477913
19EIF2AK32.13238846
20TRIM282.13124479
21BCR2.11801369
22ACVR1B1.95017003
23PNCK1.81668341
24CLK11.81003391
25WNK11.79934046
26TYK21.78604639
27MAP3K131.78456966
28CDK191.69518318
29CSNK1A1L1.67856447
30STK101.66385847
31CSNK1G31.63470659
32FGR1.62096056
33KIT1.55134290
34BRSK21.53907232
35NEK61.50621247
36FGFR21.49917884
37LIMK11.49276594
38JAK31.48518443
39TGFBR21.44015938
40TEC1.43431790
41MET1.40473478
42MUSK1.40233156
43UHMK11.39046885
44CAMK2B1.37928520
45CSNK1G11.37527621
46MST41.37309401
47FLT31.33788537
48TESK21.32946291
49ROCK21.31261060
50PLK31.29934489
51MELK1.29078074
52SIK31.26048027
53PRKG21.25929966
54TGFBR11.25828917
55IKBKE1.25351392
56NLK1.24149441
57BMPR1B1.20677451
58ADRBK21.20365701
59BCKDK1.20333372
60JAK11.18675476
61PTK2B1.17441831
62GRK11.14700670
63PRPF4B1.14425330
64CSNK1G21.12146775
65VRK11.06748392
66CAMK2D1.05644200
67MKNK11.05480724
68PRKCQ1.05448478
69IKBKB1.05432574
70TAOK31.04767313
71EIF2AK21.02726559
72FER1.02088278
73WNK31.01088532
74MAPK150.99992881
75NTRK10.99467466
76MKNK20.99082777
77PLK20.96775687
78FES0.95495001
79STK30.95211626
80GRK70.92599065
81AKT30.92171885
82IRAK20.92124199
83MARK20.91602585
84DYRK20.90655815
85PIK3CG0.89750158
86PLK40.88249403
87EPHA40.88161069
88MATK0.87239425
89MAP3K140.83452752
90SYK0.82969308
91ERBB30.82957664
92CAMK2G0.81280324
93CAMK2A0.78418467
94IRAK10.76533789
95PIK3CA0.74950963
96TRPM70.72886013
97PRKCE0.71880353
98PAK60.71124544
99NEK90.70293223
100STK160.69032000
101SGK2230.68366905
102SGK4940.68366905
103GRK50.68150517
104PRKD10.66730128
105CAMK1G0.66640809
106FYN0.63698244
107RPS6KA50.63407322
108KDR0.62957340
109MARK10.62705518
110ADRBK10.62442023
111IRAK40.59880111
112ITK0.59530908
113CDK50.54814341
114HCK0.54196232
115LCK0.54173552
116EPHB20.53882598
117IGF1R0.53711089
118HIPK20.53294469
119CSK0.52183740
120PRKG10.51986324
121MAPK130.51456925
122BUB10.50108428
123PDPK10.48407126
124INSRR0.47978388
125BMPR20.47596966
126CDK90.47393049
127BTK0.46755742
128TBK10.45875294
129SRPK10.45730819
130PAK30.45256994
131FGFR10.45138505
132TXK0.44959116
133PHKG20.43661922
134PHKG10.43661922
135CDK140.43565978
136MAP4K10.43014856
137CSNK1D0.42833052
138NEK10.42562334
139WEE10.41842001
140ABL10.41399973
141STK38L0.40770206
142CSF1R0.40651030
143MAP2K20.40245332
144MARK30.39259235
145CDK30.38165583
146CDK150.37848190
147CSNK1A10.37685133
148ERBB40.37428676
149CDK11A0.37412117
150TLK10.36524870
151NEK20.35566420
152GSK3A0.35025393
153MAP3K80.34792445
154MAPK70.34725923
155ICK0.34400338
156INSR0.34293697
157YES10.33938271
158TYRO30.33867607
159CDK180.32880843
160LYN0.32776617
161DYRK1A0.31920564
162EPHA30.31460571
163STK110.30830453
164ARAF0.30691561
165PRKACA0.29859795
166PRKACB0.29811199

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.21998176
2Fatty acid elongation_Homo sapiens_hsa000624.10889111
3Steroid biosynthesis_Homo sapiens_hsa001004.04040041
4Ether lipid metabolism_Homo sapiens_hsa005653.09780309
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04855756
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79056684
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08278337
8Sphingolipid metabolism_Homo sapiens_hsa006002.01643889
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00364601
10Histidine metabolism_Homo sapiens_hsa003401.97130658
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95703074
12Linoleic acid metabolism_Homo sapiens_hsa005911.87221818
13Protein export_Homo sapiens_hsa030601.83619185
14Propanoate metabolism_Homo sapiens_hsa006401.80173921
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.79260508
16Proteasome_Homo sapiens_hsa030501.78020726
17Axon guidance_Homo sapiens_hsa043601.77040828
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64580891
19Homologous recombination_Homo sapiens_hsa034401.63873593
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.63685063
21Measles_Homo sapiens_hsa051621.59988131
22Oxidative phosphorylation_Homo sapiens_hsa001901.54458890
23Type I diabetes mellitus_Homo sapiens_hsa049401.53741476
24Influenza A_Homo sapiens_hsa051641.47617213
25Sulfur metabolism_Homo sapiens_hsa009201.47460462
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44516990
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39822545
28Autoimmune thyroid disease_Homo sapiens_hsa053201.39774096
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.39519910
30Herpes simplex infection_Homo sapiens_hsa051681.38445888
31Viral myocarditis_Homo sapiens_hsa054161.38257300
32Phototransduction_Homo sapiens_hsa047441.37592104
33Antigen processing and presentation_Homo sapiens_hsa046121.36740449
34Serotonergic synapse_Homo sapiens_hsa047261.35508043
35Leishmaniasis_Homo sapiens_hsa051401.35107821
36One carbon pool by folate_Homo sapiens_hsa006701.31495248
37p53 signaling pathway_Homo sapiens_hsa041151.28857651
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28210440
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26701710
40Vitamin B6 metabolism_Homo sapiens_hsa007501.26609600
41Glutamatergic synapse_Homo sapiens_hsa047241.23719772
42Arachidonic acid metabolism_Homo sapiens_hsa005901.23411139
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20720928
44Legionellosis_Homo sapiens_hsa051341.19205208
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17441870
46Fanconi anemia pathway_Homo sapiens_hsa034601.15252284
47Tryptophan metabolism_Homo sapiens_hsa003801.14344777
48Morphine addiction_Homo sapiens_hsa050321.13237926
49Basal transcription factors_Homo sapiens_hsa030221.08828004
50Alzheimers disease_Homo sapiens_hsa050101.08764103
51Complement and coagulation cascades_Homo sapiens_hsa046101.06549959
52RNA degradation_Homo sapiens_hsa030181.06443536
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05313206
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03963556
55GABAergic synapse_Homo sapiens_hsa047271.01964477
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01600350
57Arginine and proline metabolism_Homo sapiens_hsa003301.01232142
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01150265
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95496640
60Butanoate metabolism_Homo sapiens_hsa006500.94302328
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94294107
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93978550
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91745919
64Parkinsons disease_Homo sapiens_hsa050120.91608697
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90220193
66Rheumatoid arthritis_Homo sapiens_hsa053230.88221604
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87937502
68Long-term depression_Homo sapiens_hsa047300.87736228
69Selenocompound metabolism_Homo sapiens_hsa004500.87148167
70Nicotine addiction_Homo sapiens_hsa050330.87016411
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.86918121
72Tuberculosis_Homo sapiens_hsa051520.84589194
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84011049
74Osteoclast differentiation_Homo sapiens_hsa043800.83573354
75Systemic lupus erythematosus_Homo sapiens_hsa053220.81369162
76Ras signaling pathway_Homo sapiens_hsa040140.79911546
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.79747482
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.79092894
79Ovarian steroidogenesis_Homo sapiens_hsa049130.78422218
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77818780
81Hepatitis C_Homo sapiens_hsa051600.77741981
82Malaria_Homo sapiens_hsa051440.77680115
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77022721
84Allograft rejection_Homo sapiens_hsa053300.76237678
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.75756652
86Primary immunodeficiency_Homo sapiens_hsa053400.74620448
87Graft-versus-host disease_Homo sapiens_hsa053320.73697240
88Asthma_Homo sapiens_hsa053100.73102652
89TNF signaling pathway_Homo sapiens_hsa046680.72417497
90RNA polymerase_Homo sapiens_hsa030200.72371223
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.71056874
92Dorso-ventral axis formation_Homo sapiens_hsa043200.70806206
93Non-homologous end-joining_Homo sapiens_hsa034500.68911609
94Retinol metabolism_Homo sapiens_hsa008300.68867189
95Mismatch repair_Homo sapiens_hsa034300.68860970
96Salivary secretion_Homo sapiens_hsa049700.67893219
97Peroxisome_Homo sapiens_hsa041460.67486970
98Taste transduction_Homo sapiens_hsa047420.67033374
99Toxoplasmosis_Homo sapiens_hsa051450.65934011
100Mineral absorption_Homo sapiens_hsa049780.65581271
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.65036930
102Renal cell carcinoma_Homo sapiens_hsa052110.64230089
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61798839
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.61207290
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61158726
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61131707
107Cocaine addiction_Homo sapiens_hsa050300.60500384
108Phagosome_Homo sapiens_hsa041450.58849469
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58718275
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57091376
111Pancreatic secretion_Homo sapiens_hsa049720.56391888
112Tight junction_Homo sapiens_hsa045300.56228597
113Fatty acid degradation_Homo sapiens_hsa000710.55626536
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55509053
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.53618648
116Pertussis_Homo sapiens_hsa051330.52916205
117RNA transport_Homo sapiens_hsa030130.51706379
118Lysosome_Homo sapiens_hsa041420.51328322
119Glutathione metabolism_Homo sapiens_hsa004800.50314903
120Hematopoietic cell lineage_Homo sapiens_hsa046400.50168678
121B cell receptor signaling pathway_Homo sapiens_hsa046620.49127061
122Cardiac muscle contraction_Homo sapiens_hsa042600.48990879
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48311552
124Chemokine signaling pathway_Homo sapiens_hsa040620.47624371
125Collecting duct acid secretion_Homo sapiens_hsa049660.47446174
126Hepatitis B_Homo sapiens_hsa051610.46898917
127Circadian entrainment_Homo sapiens_hsa047130.45727683
128Gastric acid secretion_Homo sapiens_hsa049710.45620093
129ABC transporters_Homo sapiens_hsa020100.45406177
130T cell receptor signaling pathway_Homo sapiens_hsa046600.45389816
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45092376
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45008622
133African trypanosomiasis_Homo sapiens_hsa051430.44985872
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44913018
135TGF-beta signaling pathway_Homo sapiens_hsa043500.44361213
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.43469040
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.42957527
138Endocytosis_Homo sapiens_hsa041440.42329792
139Renin secretion_Homo sapiens_hsa049240.41890661
140Staphylococcus aureus infection_Homo sapiens_hsa051500.41470031
141Nitrogen metabolism_Homo sapiens_hsa009100.39992014
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38936410
143Chemical carcinogenesis_Homo sapiens_hsa052040.38831553
144Epstein-Barr virus infection_Homo sapiens_hsa051690.38580763
145Intestinal immune network for IgA production_Homo sapiens_hsa046720.37999936
146Nucleotide excision repair_Homo sapiens_hsa034200.37957081
147Vitamin digestion and absorption_Homo sapiens_hsa049770.37884675
148Vibrio cholerae infection_Homo sapiens_hsa051100.37490883
149ECM-receptor interaction_Homo sapiens_hsa045120.36073315
150Pyrimidine metabolism_Homo sapiens_hsa002400.35556491
151Calcium signaling pathway_Homo sapiens_hsa040200.34639783
152Cholinergic synapse_Homo sapiens_hsa047250.34416554
153Caffeine metabolism_Homo sapiens_hsa002320.34170090
154cAMP signaling pathway_Homo sapiens_hsa040240.33985380
155Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32976412
156MAPK signaling pathway_Homo sapiens_hsa040100.32666116

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »