TRIM36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.42996501
2sperm motility (GO:0030317)8.12638433
3* acrosome reaction (GO:0007340)7.81171531
4multicellular organism reproduction (GO:0032504)7.39413686
5cell wall macromolecule metabolic process (GO:0044036)7.27945873
6cell wall macromolecule catabolic process (GO:0016998)7.27945873
7acrosome assembly (GO:0001675)6.65755119
8pyrimidine nucleobase catabolic process (GO:0006208)6.64358627
9epithelial cilium movement (GO:0003351)6.51149547
10plasma membrane fusion (GO:0045026)6.36213520
11axonemal dynein complex assembly (GO:0070286)6.32925432
12cilium or flagellum-dependent cell motility (GO:0001539)6.32347171
13reproduction (GO:0000003)6.31938293
14sperm-egg recognition (GO:0035036)6.31236835
15neurofilament cytoskeleton organization (GO:0060052)5.96820639
16cell-cell recognition (GO:0009988)5.57834047
17regulation of cilium movement (GO:0003352)5.57389908
18negative regulation of inclusion body assembly (GO:0090084)5.46289921
19binding of sperm to zona pellucida (GO:0007339)5.37277381
20motile cilium assembly (GO:0044458)5.36487696
21cilium movement (GO:0003341)5.33095874
22nucleobase catabolic process (GO:0046113)5.28504945
23sperm capacitation (GO:0048240)5.28082870
24central nervous system myelination (GO:0022010)5.18652347
25axon ensheathment in central nervous system (GO:0032291)5.18652347
26spermatid development (GO:0007286)5.14225196
27single fertilization (GO:0007338)5.00424876
28behavioral response to nicotine (GO:0035095)4.75511145
29microtubule depolymerization (GO:0007019)4.70054990
30detection of temperature stimulus involved in sensory perception (GO:0050961)4.69828126
31detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.69828126
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.68209003
33detection of temperature stimulus (GO:0016048)4.60983809
34protein polyglutamylation (GO:0018095)4.45634150
35presynaptic membrane assembly (GO:0097105)4.44335390
36peripheral nervous system neuron development (GO:0048935)4.43461137
37piRNA metabolic process (GO:0034587)4.32627252
38regulation of microtubule-based movement (GO:0060632)4.32561201
39microtubule polymerization or depolymerization (GO:0031109)4.28381629
40axonal fasciculation (GO:0007413)4.26869592
41neuron recognition (GO:0008038)4.23291357
42* calcium ion-dependent exocytosis (GO:0017156)4.19479574
43presynaptic membrane organization (GO:0097090)4.18966351
44postsynaptic membrane organization (GO:0001941)4.13585969
45neuron cell-cell adhesion (GO:0007158)4.05636978
46male meiosis (GO:0007140)4.05407581
47spermatid nucleus differentiation (GO:0007289)4.02177998
48establishment of mitochondrion localization (GO:0051654)4.01691575
49fertilization (GO:0009566)4.01376026
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.01045711
51regulation of inclusion body assembly (GO:0090083)3.95356386
52long-chain fatty acid biosynthetic process (GO:0042759)3.80403691
53protein localization to synapse (GO:0035418)3.73479027
54neuronal action potential (GO:0019228)3.72584610
55fatty acid elongation (GO:0030497)3.68710364
56negative regulation of dendrite morphogenesis (GO:0050774)3.67070976
57spermatogenesis (GO:0007283)3.64379079
58ventricular system development (GO:0021591)3.64277042
59central nervous system projection neuron axonogenesis (GO:0021952)3.64014808
60male gamete generation (GO:0048232)3.62736035
61synaptonemal complex organization (GO:0070193)3.61338871
62cell migration in hindbrain (GO:0021535)3.59781620
63retinal ganglion cell axon guidance (GO:0031290)3.58888875
64protein targeting to Golgi (GO:0000042)3.58660247
65cerebral cortex radially oriented cell migration (GO:0021799)3.58341891
66establishment of protein localization to Golgi (GO:0072600)3.56724780
67membrane depolarization during action potential (GO:0086010)3.56511864
68vocalization behavior (GO:0071625)3.52643743
69neural tube formation (GO:0001841)3.52490679
70response to pheromone (GO:0019236)3.41299323
71gamete generation (GO:0007276)3.38691303
72transmission of nerve impulse (GO:0019226)3.35035513
73microtubule severing (GO:0051013)3.33211941
74negative regulation of calcium ion transport into cytosol (GO:0010523)3.31494975
75regulation of collateral sprouting (GO:0048670)3.29885077
76protein localization to cilium (GO:0061512)3.28220184
77synapse assembly (GO:0007416)3.27038597
78neurotransmitter-gated ion channel clustering (GO:0072578)3.27010829
79cell recognition (GO:0008037)3.26409892
80limb bud formation (GO:0060174)3.26207527
81positive regulation of dendritic spine morphogenesis (GO:0061003)3.26076400
82neuronal ion channel clustering (GO:0045161)3.24838189
83protein K11-linked deubiquitination (GO:0035871)3.20127060
84response to acidic pH (GO:0010447)3.18680093
85intraciliary transport (GO:0042073)3.18418820
86retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17353345
87synaptonemal complex assembly (GO:0007130)3.15801897
88cerebral cortex neuron differentiation (GO:0021895)3.14200977
89olfactory bulb development (GO:0021772)3.13994190
90positive regulation of mitochondrial fission (GO:0090141)3.13636891
91auditory behavior (GO:0031223)3.12951258
92axon development (GO:0061564)3.11605750
93spinal cord development (GO:0021510)3.09787456
94somite development (GO:0061053)3.08560608
95nonmotile primary cilium assembly (GO:0035058)3.08104267
96organic cation transport (GO:0015695)3.01193188
97dendritic spine morphogenesis (GO:0060997)3.00972445
98regulation of development, heterochronic (GO:0040034)3.00961119
99central nervous system neuron axonogenesis (GO:0021955)3.00435788
100calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.97622675
101response to methylmercury (GO:0051597)2.97024821
102gamma-aminobutyric acid transport (GO:0015812)2.96434520
103ionotropic glutamate receptor signaling pathway (GO:0035235)2.95440872
104centriole replication (GO:0007099)2.91718123
105axoneme assembly (GO:0035082)2.91511593
106substrate-independent telencephalic tangential migration (GO:0021826)2.91310548
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.91310548
108cilium morphogenesis (GO:0060271)2.91272806
109urinary tract smooth muscle contraction (GO:0014848)2.91100080
110protein localization to Golgi apparatus (GO:0034067)2.90173270
111regulation of timing of cell differentiation (GO:0048505)2.88936363
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88931163
113DNA methylation involved in gamete generation (GO:0043046)2.88802071
114glycosphingolipid biosynthetic process (GO:0006688)2.87298224
115dendrite morphogenesis (GO:0048813)2.87129170
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86794305
117cellular process involved in reproduction in multicellular organism (GO:0022412)2.84517995
118synaptic vesicle maturation (GO:0016188)2.83600089
119microtubule-based movement (GO:0007018)2.83010240
120synaptic transmission, glutamatergic (GO:0035249)2.82607459
121ensheathment of neurons (GO:0007272)2.81781634
122axon ensheathment (GO:0008366)2.81781634
123sympathetic nervous system development (GO:0048485)2.81431976
124mechanosensory behavior (GO:0007638)2.81309816
125myelination (GO:0042552)2.80804847
126synaptic transmission, cholinergic (GO:0007271)2.80525436
127positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80471227
128positive regulation of synapse assembly (GO:0051965)2.80372778
129hippocampus development (GO:0021766)2.80122898
130regulation of synapse structural plasticity (GO:0051823)2.79783674
131regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78390153
132negative regulation of oligodendrocyte differentiation (GO:0048715)2.76104230
133cerebral cortex cell migration (GO:0021795)2.75072421
134neuromuscular synaptic transmission (GO:0007274)2.75010392
135regulation of platelet aggregation (GO:0090330)2.74847905
136sequestering of actin monomers (GO:0042989)2.74594967
137cilium organization (GO:0044782)2.74096628
138cilium assembly (GO:0042384)2.74038810
139adult walking behavior (GO:0007628)2.73406039
140glutamate receptor signaling pathway (GO:0007215)2.73238382
141germ cell development (GO:0007281)2.72572228
142synaptic vesicle exocytosis (GO:0016079)2.72569378
143mitochondrion transport along microtubule (GO:0047497)2.72287767
144establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72287767
145negative regulation of homotypic cell-cell adhesion (GO:0034111)2.71841588
146seminiferous tubule development (GO:0072520)2.70407270
147regulation of synaptic vesicle exocytosis (GO:2000300)2.68191024
148photoreceptor cell differentiation (GO:0046530)2.67463286
149eye photoreceptor cell differentiation (GO:0001754)2.67463286
150negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67323981
151protein refolding (GO:0042026)2.65891020
152regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.65300845
153cholesterol biosynthetic process (GO:0006695)2.65248604
154dendrite development (GO:0016358)2.64725796
155single strand break repair (GO:0000012)2.64172368
156forebrain neuron differentiation (GO:0021879)2.63082055
157neuron migration (GO:0001764)2.61791403
158ganglion development (GO:0061548)2.61566549
159sterol biosynthetic process (GO:0016126)2.61345113
160enteric nervous system development (GO:0048484)2.58877201
161multicellular organismal reproductive process (GO:0048609)2.58007802
162negative regulation of amino acid transport (GO:0051956)2.57094442
163myelin maintenance (GO:0043217)2.57036237
164sexual reproduction (GO:0019953)2.55774418
165neuronal action potential propagation (GO:0019227)2.51301000
166left/right pattern formation (GO:0060972)2.48909020
167detection of mechanical stimulus involved in sensory perception (GO:0050974)2.46691979
168behavioral response to pain (GO:0048266)2.45486610
169microtubule bundle formation (GO:0001578)2.45190348
170negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.41305703
171negative regulation of neurotransmitter secretion (GO:0046929)2.37783493
172mitochondrion degradation (GO:0000422)2.35879043
173polyol catabolic process (GO:0046174)2.35748931
174negative regulation of dendrite development (GO:2000171)2.34810471
175glycerol ether metabolic process (GO:0006662)2.34709477
176axon cargo transport (GO:0008088)2.34422486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.11187775
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.75046928
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.11346065
4VDR_22108803_ChIP-Seq_LS180_Human2.80619601
5TAF15_26573619_Chip-Seq_HEK293_Human2.62015573
6GBX2_23144817_ChIP-Seq_PC3_Human2.36264969
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27897812
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.26031196
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25632920
10CBX2_27304074_Chip-Seq_ESCs_Mouse1.90233526
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89490813
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81053045
13* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79234882
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73641996
15REST_21632747_ChIP-Seq_MESCs_Mouse1.73352127
16TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72492379
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67166791
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.66562863
19RNF2_27304074_Chip-Seq_NSC_Mouse1.66452160
20EWS_26573619_Chip-Seq_HEK293_Human1.65184845
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60966212
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60832301
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57292243
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55313639
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.54990112
26* KDM2B_26808549_Chip-Seq_REH_Human1.54718542
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.53719501
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51711129
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51460947
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50601523
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49662445
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49499413
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.47501126
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44127947
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43904182
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43619358
37CMYC_18555785_Chip-Seq_ESCs_Mouse1.42650840
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40176493
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39445199
40SMAD4_21799915_ChIP-Seq_A2780_Human1.38764164
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38536128
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.38419446
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38375779
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37813847
45* EZH2_27294783_Chip-Seq_ESCs_Mouse1.36388641
46P300_19829295_ChIP-Seq_ESCs_Human1.35982379
47IRF1_19129219_ChIP-ChIP_H3396_Human1.35348904
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34979830
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.34158747
50ER_23166858_ChIP-Seq_MCF-7_Human1.33175778
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33025799
52RUNX2_22187159_ChIP-Seq_PCA_Human1.33012335
53* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31171201
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30967257
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30333117
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28212584
57P53_22387025_ChIP-Seq_ESCs_Mouse1.28132309
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.27653794
59* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27593945
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26605435
61P300_18555785_Chip-Seq_ESCs_Mouse1.26448187
62* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26318820
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25537412
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24115622
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23245494
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23049258
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22297391
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.21990050
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.21537813
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.21463687
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21236474
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20775963
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20462545
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18413557
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18413557
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16554250
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14344655
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.14208974
79DROSHA_22980978_ChIP-Seq_HELA_Human1.14158528
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13482311
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12718068
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.12152500
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11865392
84ZNF274_21170338_ChIP-Seq_K562_Hela1.11848254
85* STAT3_23295773_ChIP-Seq_U87_Human1.11808777
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11078768
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.10825712
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10607032
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.09969877
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09553445
91AHR_22903824_ChIP-Seq_MCF-7_Human1.09298833
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09188004
93TCF4_23295773_ChIP-Seq_U87_Human1.08741947
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.08575755
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07343064
96AR_21572438_ChIP-Seq_LNCaP_Human1.07085701
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.06922949
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06817906
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06580227
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.04777312
101STAT1_17558387_ChIP-Seq_HELA_Human1.04746988
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04664498
103JUN_21703547_ChIP-Seq_K562_Human1.04134208
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03883896
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.03592791
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.03393097
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03277817
108* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03035480
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.02509279
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02340765
111NANOG_19829295_ChIP-Seq_ESCs_Human1.02334619
112SOX2_19829295_ChIP-Seq_ESCs_Human1.02334619
113GF1_26923725_Chip-Seq_HPCs_Mouse1.02096548
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.01638039
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01563560
116SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01524979
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.01466284
118* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01466166
119TP53_22573176_ChIP-Seq_HFKS_Human1.00659113
120PU1_27457419_Chip-Seq_LIVER_Mouse1.00172160
121IGF1R_20145208_ChIP-Seq_DFB_Human0.99571742
122AR_25329375_ChIP-Seq_VCAP_Human0.99444918
123WDR5_24793694_ChIP-Seq_LNCAP_Human0.99315801
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99264629
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99261419
126* REST_18959480_ChIP-ChIP_MESCs_Mouse0.98845458
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.98732989
128TBL1_22424771_ChIP-Seq_293T_Human0.97713282
129CBP_20019798_ChIP-Seq_JUKART_Human0.97541277
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97541277
131FUS_26573619_Chip-Seq_HEK293_Human0.97152115
132RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96575066
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96575066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.31488584
2MP0002735_abnormal_chemical_nociception5.00978306
3MP0004270_analgesia4.50859934
4MP0001986_abnormal_taste_sensitivity4.14963356
5MP0001968_abnormal_touch/_nociception3.94084832
6MP0002736_abnormal_nociception_after3.67284456
7MP0006276_abnormal_autonomic_nervous3.16774950
8MP0002734_abnormal_mechanical_nocicepti3.06792485
9MP0002822_catalepsy3.05063179
10MP0003698_abnormal_male_reproductive2.93682852
11MP0000920_abnormal_myelination2.71455270
12MP0002733_abnormal_thermal_nociception2.61047446
13MP0004858_abnormal_nervous_system2.53952570
14MP0005394_taste/olfaction_phenotype2.37256643
15MP0005499_abnormal_olfactory_system2.37256643
16MP0003787_abnormal_imprinting2.32517461
17MP0003122_maternal_imprinting2.31862500
18MP0001929_abnormal_gametogenesis2.30992086
19MP0001970_abnormal_pain_threshold2.30777530
20MP0003880_abnormal_central_pattern2.22321061
21MP0002272_abnormal_nervous_system2.18206351
22MP0003121_genomic_imprinting2.16789679
23MP0004742_abnormal_vestibular_system2.16169636
24MP0008789_abnormal_olfactory_epithelium2.14365600
25MP0009046_muscle_twitch2.12115876
26MP0005423_abnormal_somatic_nervous1.81215006
27MP0003329_amyloid_beta_deposits1.77346582
28MP0001984_abnormal_olfaction1.75780397
29MP0008995_early_reproductive_senescence1.75571971
30MP0002067_abnormal_sensory_capabilities1.72606224
31MP0000778_abnormal_nervous_system1.64580769
32MP0002234_abnormal_pharynx_morphology1.62237421
33MP0006292_abnormal_olfactory_placode1.60560180
34MP0001486_abnormal_startle_reflex1.58488177
35MP0002229_neurodegeneration1.53249670
36MP0002184_abnormal_innervation1.51870556
37MP0002161_abnormal_fertility/fecundity1.51659288
38MP0001905_abnormal_dopamine_level1.49981541
39MP0003950_abnormal_plasma_membrane1.49732786
40MP0001485_abnormal_pinna_reflex1.45685471
41MP0000955_abnormal_spinal_cord1.44089743
42MP0000631_abnormal_neuroendocrine_gland1.43297878
43MP0001529_abnormal_vocalization1.38742203
44MP0003634_abnormal_glial_cell1.38368700
45MP0008260_abnormal_autophagy1.38218016
46MP0002064_seizures1.38038636
47MP0003890_abnormal_embryonic-extraembry1.37303754
48MP0001348_abnormal_lacrimal_gland1.37177149
49MP0002751_abnormal_autonomic_nervous1.35939234
50MP0000049_abnormal_middle_ear1.35527968
51MP0008877_abnormal_DNA_methylation1.34026202
52MP0002210_abnormal_sex_determination1.33254489
53MP0006072_abnormal_retinal_apoptosis1.32623839
54MP0004133_heterotaxia1.32461087
55MP0002882_abnormal_neuron_morphology1.32386853
56MP0003635_abnormal_synaptic_transmissio1.30713982
57MP0002653_abnormal_ependyma_morphology1.28268597
58MP0002638_abnormal_pupillary_reflex1.24985531
59MP0004811_abnormal_neuron_physiology1.23760350
60MP0002572_abnormal_emotion/affect_behav1.23009409
61MP0002752_abnormal_somatic_nervous1.22249876
62MP0004859_abnormal_synaptic_plasticity1.20919236
63MP0005187_abnormal_penis_morphology1.18862993
64MP0002063_abnormal_learning/memory/cond1.17751196
65MP0003718_maternal_effect1.17475595
66MP0009745_abnormal_behavioral_response1.16291563
67MP0000372_irregular_coat_pigmentation1.15977755
68MP0001963_abnormal_hearing_physiology1.15683157
69MP0004142_abnormal_muscle_tone1.14972587
70MP0005171_absent_coat_pigmentation1.14526161
71MP0003119_abnormal_digestive_system1.14036585
72MP0001440_abnormal_grooming_behavior1.09155539
73MP0003633_abnormal_nervous_system1.04689760
74MP0003011_delayed_dark_adaptation1.02804865
75MP0001145_abnormal_male_reproductive1.02757523
76MP0005409_darkened_coat_color1.01956383
77MP0000604_amyloidosis1.01545074
78MP0003631_nervous_system_phenotype1.00726727
79MP0002233_abnormal_nose_morphology0.95734832
80MP0010386_abnormal_urinary_bladder0.94840589
81MP0002066_abnormal_motor_capabilities/c0.92748056
82MP0003938_abnormal_ear_development0.92617384
83MP0005551_abnormal_eye_electrophysiolog0.91629321
84MP0005248_abnormal_Harderian_gland0.91082487
85MP0003690_abnormal_glial_cell0.90989629
86MP0002160_abnormal_reproductive_system0.90604423
87MP0004885_abnormal_endolymph0.90210619
88MP0004147_increased_porphyrin_level0.89626737
89MP0003937_abnormal_limbs/digits/tail_de0.88732513
90MP0001293_anophthalmia0.87614700
91MP0000653_abnormal_sex_gland0.87427874
92MP0000015_abnormal_ear_pigmentation0.86993600
93MP0003221_abnormal_cardiomyocyte_apopto0.86918076
94MP0005623_abnormal_meninges_morphology0.85393424
95MP0000647_abnormal_sebaceous_gland0.85197312
96MP0005391_vision/eye_phenotype0.84662084
97MP0008569_lethality_at_weaning0.84196076
98MP0002909_abnormal_adrenal_gland0.84046550
99MP0002069_abnormal_eating/drinking_beha0.83994391
100MP0002557_abnormal_social/conspecific_i0.79097275
101MP0003632_abnormal_nervous_system0.79078842
102MP0005386_behavior/neurological_phenoty0.78430848
103MP0004924_abnormal_behavior0.78430848
104MP0003755_abnormal_palate_morphology0.78306173
105MP0006082_CNS_inflammation0.77724580
106MP0000026_abnormal_inner_ear0.76805331
107MP0002938_white_spotting0.75335686
108MP0001299_abnormal_eye_distance/0.74037124
109MP0000566_synostosis0.71509408
110MP0001502_abnormal_circadian_rhythm0.70222146
111MP0005253_abnormal_eye_physiology0.69161293
112MP0003656_abnormal_erythrocyte_physiolo0.67971132
113MP0003183_abnormal_peptide_metabolism0.66534026
114MP0000569_abnormal_digit_pigmentation0.64709570
115MP0002152_abnormal_brain_morphology0.60505023
116MP0001188_hyperpigmentation0.57521293
117MP0002102_abnormal_ear_morphology0.57027814
118MP0004134_abnormal_chest_morphology0.56142532
119MP0005645_abnormal_hypothalamus_physiol0.55199758
120MP0003136_yellow_coat_color0.54378252
121MP0005377_hearing/vestibular/ear_phenot0.52614358
122MP0003878_abnormal_ear_physiology0.52614358
123MP0001270_distended_abdomen0.51650348
124MP0002148_abnormal_hypersensitivity_rea0.51350002
125MP0001501_abnormal_sleep_pattern0.50726570
126MP0005195_abnormal_posterior_eye0.49728527
127MP0005646_abnormal_pituitary_gland0.48336159
128MP0001851_eye_inflammation0.45826426
129MP0000462_abnormal_digestive_system0.44901920
130MP0003861_abnormal_nervous_system0.44404883
131MP0001765_abnormal_ion_homeostasis0.44249699
132MP0000534_abnormal_ureter_morphology0.43725340
133MP0002163_abnormal_gland_morphology0.40824069
134MP0003879_abnormal_hair_cell0.40606515

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)8.39721951
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.39721951
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.86646553
4Abnormal respiratory epithelium morphology (HP:0012253)5.90416033
5Abnormal respiratory motile cilium morphology (HP:0005938)5.90416033
6Abnormal respiratory motile cilium physiology (HP:0012261)5.67783326
7Ulnar claw (HP:0001178)5.13676854
8Abnormal ciliary motility (HP:0012262)4.82591317
9Segmental peripheral demyelination/remyelination (HP:0003481)4.44876794
10Rhinitis (HP:0012384)4.41353292
11Degeneration of the lateral corticospinal tracts (HP:0002314)4.26607311
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.26607311
13Termporal pattern (HP:0011008)4.00936178
14Insidious onset (HP:0003587)4.00936178
15Abnormality of the corticospinal tract (HP:0002492)3.78093539
16Infertility (HP:0000789)3.76449424
17Supranuclear gaze palsy (HP:0000605)3.54426219
18Neurofibrillary tangles (HP:0002185)3.42639535
19Peripheral hypomyelination (HP:0007182)3.35084634
20Myokymia (HP:0002411)3.34875756
21Chronic bronchitis (HP:0004469)3.29410306
22Onion bulb formation (HP:0003383)3.27910646
23Chronic hepatic failure (HP:0100626)3.24322756
24Drooling (HP:0002307)3.20735952
25Polyphagia (HP:0002591)3.16010143
26Cortical dysplasia (HP:0002539)3.14470391
27Focal motor seizures (HP:0011153)3.03715214
28Medial flaring of the eyebrow (HP:0010747)3.03535385
29Hyperventilation (HP:0002883)3.01404317
30Decreased motor nerve conduction velocity (HP:0003431)2.95106546
31Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.94721770
32Excessive salivation (HP:0003781)2.91567766
33Intestinal atresia (HP:0011100)2.85483579
34Abnormality of the labia minora (HP:0012880)2.79496041
35Pheochromocytoma (HP:0002666)2.77836640
36Nephronophthisis (HP:0000090)2.73780198
37Steppage gait (HP:0003376)2.73382424
38True hermaphroditism (HP:0010459)2.72908765
39Spastic gait (HP:0002064)2.71872404
40Ankle clonus (HP:0011448)2.69839023
41Amyotrophic lateral sclerosis (HP:0007354)2.69802197
42Volvulus (HP:0002580)2.68721828
43Action tremor (HP:0002345)2.67021920
44Pancreatic fibrosis (HP:0100732)2.65674970
45Retinal dysplasia (HP:0007973)2.63578652
46Pancreatic cysts (HP:0001737)2.60394705
47Hypothermia (HP:0002045)2.59586401
48Foot dorsiflexor weakness (HP:0009027)2.56149326
49Absent speech (HP:0001344)2.55321835
50Male infertility (HP:0003251)2.54873774
51Broad-based gait (HP:0002136)2.54374761
52Parakeratosis (HP:0001036)2.53609165
53Neuroendocrine neoplasm (HP:0100634)2.53559316
54Optic nerve hypoplasia (HP:0000609)2.51923140
55Sensory axonal neuropathy (HP:0003390)2.51605702
56Nasal polyposis (HP:0100582)2.45127870
57Hammertoe (HP:0001765)2.45023124
58Genital tract atresia (HP:0001827)2.42543784
59Choroideremia (HP:0001139)2.42212233
60Gait imbalance (HP:0002141)2.37457862
61Autoamputation (HP:0001218)2.35845488
62Bronchiectasis (HP:0002110)2.35150048
63Bony spicule pigmentary retinopathy (HP:0007737)2.33682046
64Impaired vibration sensation in the lower limbs (HP:0002166)2.33211699
65Vaginal atresia (HP:0000148)2.31941263
66Progressive cerebellar ataxia (HP:0002073)2.30507497
67Spastic tetraplegia (HP:0002510)2.27617849
68Distal sensory impairment (HP:0002936)2.26807556
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26786163
70Lower limb muscle weakness (HP:0007340)2.26401791
71Cerebral inclusion bodies (HP:0100314)2.23918729
72Abnormality of the foot musculature (HP:0001436)2.21507132
73Septo-optic dysplasia (HP:0100842)2.20579371
74Spastic tetraparesis (HP:0001285)2.19823314
75Congenital primary aphakia (HP:0007707)2.16800840
76Failure to thrive in infancy (HP:0001531)2.16041509
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15359782
78Hypoplasia of the brainstem (HP:0002365)2.15359782
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14533411
80Exotropia (HP:0000577)2.14301116
81Urinary urgency (HP:0000012)2.13299891
82Epileptic encephalopathy (HP:0200134)2.13236211
83Tubulointerstitial nephritis (HP:0001970)2.11205525
84Slow saccadic eye movements (HP:0000514)2.10254601
85Decreased central vision (HP:0007663)2.09269343
86Type II lissencephaly (HP:0007260)2.08392359
87Agitation (HP:0000713)2.07995208
88Oligodactyly (hands) (HP:0001180)2.07090826
89Postaxial hand polydactyly (HP:0001162)2.04701298
90Genetic anticipation (HP:0003743)2.01971975
91Dyschromatopsia (HP:0007641)2.01043771
92Anencephaly (HP:0002323)1.99925919
93Bronchitis (HP:0012387)1.99853776
94Nephrogenic diabetes insipidus (HP:0009806)1.96890572
95Thyroid-stimulating hormone excess (HP:0002925)1.96805812
96Abnormality of the lower motor neuron (HP:0002366)1.95859203
97Abnormality of the renal medulla (HP:0100957)1.95392889
98Inappropriate behavior (HP:0000719)1.94197238
99Esotropia (HP:0000565)1.93986055
100Dialeptic seizures (HP:0011146)1.93820689
101Dysautonomia (HP:0002459)1.93051905
102Pendular nystagmus (HP:0012043)1.92392011
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91132338
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.88710618
105Inability to walk (HP:0002540)1.88704342
106Abnormal hair whorl (HP:0010721)1.88356067
107Aplasia/Hypoplasia of the lens (HP:0008063)1.87673262
108Narrow forehead (HP:0000341)1.87595279
109Intellectual disability, moderate (HP:0002342)1.87578553
110Cerebral hemorrhage (HP:0001342)1.87339949
111Micropenis (HP:0000054)1.85905531
112Supernumerary spleens (HP:0009799)1.85791048
113Hyporeflexia of lower limbs (HP:0002600)1.84706667
114Urinary bladder sphincter dysfunction (HP:0002839)1.84686792
115Dyskinesia (HP:0100660)1.83359655
116Recurrent sinusitis (HP:0011108)1.83199964
117Lissencephaly (HP:0001339)1.83186923
118Occipital encephalocele (HP:0002085)1.82529368
119Peripheral demyelination (HP:0011096)1.81940287
120Hypomagnesemia (HP:0002917)1.81130689
121Abolished electroretinogram (ERG) (HP:0000550)1.80093799
122Febrile seizures (HP:0002373)1.79605445
123Amblyopia (HP:0000646)1.79086145
124Short tibia (HP:0005736)1.78131903
125Tubular atrophy (HP:0000092)1.77569899
126Abnormal eating behavior (HP:0100738)1.77516597
127Hypsarrhythmia (HP:0002521)1.76591926
128Gastrointestinal atresia (HP:0002589)1.76033957
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75882530
130Protruding tongue (HP:0010808)1.74963793
131Limb dystonia (HP:0002451)1.74264324
132Attenuation of retinal blood vessels (HP:0007843)1.73815136
133Growth hormone deficiency (HP:0000824)1.73328680
134Specific learning disability (HP:0001328)1.72314085
135Hepatoblastoma (HP:0002884)1.72020258
136Atonic seizures (HP:0010819)1.71942691
137Akinesia (HP:0002304)1.71800843
138Postaxial foot polydactyly (HP:0001830)1.71222162
139Morphological abnormality of the pyramidal tract (HP:0002062)1.70774940
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.70300041
141Pachygyria (HP:0001302)1.69849369
142Thyroid carcinoma (HP:0002890)1.69347964
143Molar tooth sign on MRI (HP:0002419)1.68674043
144Abnormality of midbrain morphology (HP:0002418)1.68674043
145Polymicrogyria (HP:0002126)1.68059844
146EEG with generalized epileptiform discharges (HP:0011198)1.67815341
147Abnormality of the nasal mucosa (HP:0000433)1.66963241
148Absent septum pellucidum (HP:0001331)1.66618982
149Recurrent otitis media (HP:0000403)1.62892864
150Submucous cleft hard palate (HP:0000176)1.62019936
151External ophthalmoplegia (HP:0000544)1.61222039
152Progressive inability to walk (HP:0002505)1.59292057
153Upper limb muscle weakness (HP:0003484)1.58898383
154Focal seizures (HP:0007359)1.58817303
155Tubulointerstitial abnormality (HP:0001969)1.58445571
156Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.57494722
157Abnormality of magnesium homeostasis (HP:0004921)1.55963336
158Impaired proprioception (HP:0010831)1.54909057
159Poor coordination (HP:0002370)1.54575513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.69155849
2PDK34.06008823
3PDK44.06008823
4TRIM283.25567863
5TESK13.15131507
6WNK33.06458973
7PRKD32.82871723
8PDK22.65486411
9WNK42.56043571
10EPHB12.34204421
11CASK2.26441885
12ICK2.17334654
13NTRK12.07882264
14LIMK12.06084239
15EPHA42.05402660
16WNK11.99320454
17DYRK31.96230420
18PLK41.96012146
19OXSR11.95507098
20BCR1.93684877
21PNCK1.93025637
22MAPKAPK51.92203054
23MINK11.88820504
24LMTK21.83607788
25MAP4K21.78271107
26ERBB31.73161088
27SIK21.67292110
28RIPK41.63038155
29MARK11.60247589
30BMPR1B1.52916456
31NTRK21.49344962
32MAP2K71.46786387
33SGK2231.40965411
34SGK4941.40965411
35BRD41.38632084
36NTRK31.37877955
37INSRR1.37035976
38MAPK131.35516769
39PKN11.31790526
40SIK31.31036850
41DYRK21.31014082
42MAP3K41.22758667
43SRPK11.20241719
44PTK2B1.18095430
45PBK1.17943208
46IRAK11.16682258
47ARAF1.12734475
48IRAK21.12122916
49MAP3K91.11090709
50MAP3K21.10956973
51YES11.03911527
52BLK1.00823523
53EPHB21.00023597
54PAK30.95825994
55MATK0.92109974
56DYRK1A0.90621829
57STK38L0.89050968
58TYRO30.87760837
59RPS6KA40.87061318
60TESK20.86864545
61GRK50.85938356
62MST40.85767481
63KSR20.85052346
64FRK0.84418708
65GRK70.83058514
66CAMKK20.81898351
67PAK60.81483257
68UHMK10.81227564
69MAP3K60.80910005
70PHKG20.80343173
71PHKG10.80343173
72CAMK40.79629287
73EPHA30.77631419
74PDK10.76378472
75ZAK0.74414576
76MAPK150.73292542
77CSNK1G30.72535596
78BMPR20.72036804
79RET0.71663890
80MKNK20.69700378
81MAP3K140.68389487
82MKNK10.67516770
83ADRBK20.66786154
84ACVR1B0.66548305
85CSNK1A1L0.65932607
86DAPK20.65144788
87CSNK1G20.64676001
88DDR20.64401350
89AKT30.63880599
90MARK30.63787867
91PDPK10.62805108
92CDK50.62239554
93KSR10.60266500
94CDK140.58263716
95NUAK10.58116078
96NEK60.57985952
97CDK11A0.56087158
98SGK20.54173678
99CAMK2A0.53857952
100PRKCE0.52979448
101MARK20.52736036
102RPS6KA20.51354242
103ROCK20.50414169
104LATS10.46900814
105CAMK10.46774520
106TNIK0.46577883
107MET0.45401736
108MUSK0.44294053
109CDK190.43924997
110PRPF4B0.43810949
111MAP2K20.43537426
112CDK180.43371415
113CAMK2D0.42842745
114CSNK1A10.42781295
115FGR0.41326625
116PRKCG0.40703291
117PRKACA0.40431118
118MAP2K40.40176148
119PRKCQ0.39456382
120PINK10.39446496
121DYRK1B0.39017927
122PRKACB0.38308019
123CAMK1G0.37878410
124CAMK2B0.36742080
125CSNK1D0.36536443
126LATS20.36250302
127CAMK2G0.35538426
128CSNK1E0.35387148
129CDK150.34173828
130BCKDK0.33872571
131MAP3K10.32854836
132CSNK1G10.31348248
133CDK30.31338293
134NEK20.30807317
135MAP3K50.30317528
136PRKG10.30151334
137MAP2K60.29848667
138CLK10.29007552
139PLK20.28939970
140PRKCZ0.28090493
141VRK10.27914474
142FGFR20.27520585
143BRAF0.27334923
144PLK10.27066212
145GSK3B0.26969356
146GRK10.26794207
147STK380.26029703

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.46499883
2Steroid biosynthesis_Homo sapiens_hsa001003.43433076
3Ether lipid metabolism_Homo sapiens_hsa005652.62590841
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.20113030
5Synaptic vesicle cycle_Homo sapiens_hsa047212.12177223
6Fatty acid elongation_Homo sapiens_hsa000622.09757538
7Dorso-ventral axis formation_Homo sapiens_hsa043201.90941263
8Butanoate metabolism_Homo sapiens_hsa006501.86466067
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81045457
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78932358
11Collecting duct acid secretion_Homo sapiens_hsa049661.78334987
12Linoleic acid metabolism_Homo sapiens_hsa005911.72039819
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63646678
14Protein export_Homo sapiens_hsa030601.62124291
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52494644
16Taste transduction_Homo sapiens_hsa047421.51460445
17Mineral absorption_Homo sapiens_hsa049781.47327491
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46827804
19Vitamin B6 metabolism_Homo sapiens_hsa007501.40907043
20Phototransduction_Homo sapiens_hsa047441.39970453
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38740070
22Salmonella infection_Homo sapiens_hsa051321.38668313
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37566324
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.36541218
25Axon guidance_Homo sapiens_hsa043601.34341724
26Phagosome_Homo sapiens_hsa041451.33671367
27Serotonergic synapse_Homo sapiens_hsa047261.31312138
28Fatty acid biosynthesis_Homo sapiens_hsa000611.29775926
29Sphingolipid metabolism_Homo sapiens_hsa006001.28493381
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27198483
31Rheumatoid arthritis_Homo sapiens_hsa053231.27152968
32Olfactory transduction_Homo sapiens_hsa047401.26664560
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24346092
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21910985
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15704488
36Autoimmune thyroid disease_Homo sapiens_hsa053201.11388610
37Graft-versus-host disease_Homo sapiens_hsa053321.11384183
38Endocytosis_Homo sapiens_hsa041441.10141412
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08497828
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08427216
41Oxidative phosphorylation_Homo sapiens_hsa001901.08415933
42Dopaminergic synapse_Homo sapiens_hsa047281.07765939
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03635363
44Glutamatergic synapse_Homo sapiens_hsa047241.02180232
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00306041
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.99948138
47Huntingtons disease_Homo sapiens_hsa050160.99211315
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98384829
49Propanoate metabolism_Homo sapiens_hsa006400.95206852
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93158025
51Regulation of autophagy_Homo sapiens_hsa041400.93118599
52Cardiac muscle contraction_Homo sapiens_hsa042600.92368491
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90360230
54Vibrio cholerae infection_Homo sapiens_hsa051100.89302443
55Cholinergic synapse_Homo sapiens_hsa047250.87197903
56Insulin secretion_Homo sapiens_hsa049110.86721757
57Fanconi anemia pathway_Homo sapiens_hsa034600.86372269
58Gap junction_Homo sapiens_hsa045400.85963599
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.85255370
60Alcoholism_Homo sapiens_hsa050340.85199506
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84362661
62Type II diabetes mellitus_Homo sapiens_hsa049300.83952350
63Circadian entrainment_Homo sapiens_hsa047130.82779079
64Pyruvate metabolism_Homo sapiens_hsa006200.81393596
65Oocyte meiosis_Homo sapiens_hsa041140.80227753
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.79433267
67Allograft rejection_Homo sapiens_hsa053300.79238729
68Alzheimers disease_Homo sapiens_hsa050100.78556654
69Basal transcription factors_Homo sapiens_hsa030220.78549841
70RNA degradation_Homo sapiens_hsa030180.77523269
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76397260
72Peroxisome_Homo sapiens_hsa041460.74351698
73Parkinsons disease_Homo sapiens_hsa050120.74330619
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74092581
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73816143
76ErbB signaling pathway_Homo sapiens_hsa040120.73745742
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73459116
78Amphetamine addiction_Homo sapiens_hsa050310.73385831
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73130138
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72439838
81Renin secretion_Homo sapiens_hsa049240.71240251
82Salivary secretion_Homo sapiens_hsa049700.71110626
83Circadian rhythm_Homo sapiens_hsa047100.70873362
84Morphine addiction_Homo sapiens_hsa050320.68898810
85Ras signaling pathway_Homo sapiens_hsa040140.68728401
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68521778
87Tryptophan metabolism_Homo sapiens_hsa003800.68432216
88Gastric acid secretion_Homo sapiens_hsa049710.66858014
89Arachidonic acid metabolism_Homo sapiens_hsa005900.66593243
90Hippo signaling pathway_Homo sapiens_hsa043900.62477907
91Inositol phosphate metabolism_Homo sapiens_hsa005620.62454916
92Hedgehog signaling pathway_Homo sapiens_hsa043400.61726328
93Caffeine metabolism_Homo sapiens_hsa002320.60818563
94MAPK signaling pathway_Homo sapiens_hsa040100.59099268
95Long-term potentiation_Homo sapiens_hsa047200.58715022
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57190484
97Glycerolipid metabolism_Homo sapiens_hsa005610.56673025
98Asthma_Homo sapiens_hsa053100.55988715
99VEGF signaling pathway_Homo sapiens_hsa043700.55486694
100Calcium signaling pathway_Homo sapiens_hsa040200.53657504
101Basal cell carcinoma_Homo sapiens_hsa052170.53028921
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.52760585
103Fat digestion and absorption_Homo sapiens_hsa049750.52471617
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.51759346
105T cell receptor signaling pathway_Homo sapiens_hsa046600.51542622
106Oxytocin signaling pathway_Homo sapiens_hsa049210.51284928
107mRNA surveillance pathway_Homo sapiens_hsa030150.51140254
108Nitrogen metabolism_Homo sapiens_hsa009100.50092998
109ABC transporters_Homo sapiens_hsa020100.49779755
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.49493053
111Cocaine addiction_Homo sapiens_hsa050300.48984369
112GABAergic synapse_Homo sapiens_hsa047270.47766579
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47636342
114Pertussis_Homo sapiens_hsa051330.47431880
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47010208
116Sulfur metabolism_Homo sapiens_hsa009200.46994286
117Fatty acid metabolism_Homo sapiens_hsa012120.46841085
118RNA transport_Homo sapiens_hsa030130.46530637
119Shigellosis_Homo sapiens_hsa051310.46454673
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44671107
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.44643205
122Arginine and proline metabolism_Homo sapiens_hsa003300.44452601
123Renal cell carcinoma_Homo sapiens_hsa052110.43831481
124Estrogen signaling pathway_Homo sapiens_hsa049150.43602986
125African trypanosomiasis_Homo sapiens_hsa051430.43518738
126Tuberculosis_Homo sapiens_hsa051520.43348623
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42555830
128Long-term depression_Homo sapiens_hsa047300.42486766
129Pancreatic secretion_Homo sapiens_hsa049720.42398656
130cAMP signaling pathway_Homo sapiens_hsa040240.40814365
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40804009
132Chemokine signaling pathway_Homo sapiens_hsa040620.39715992
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39434906
134Nicotine addiction_Homo sapiens_hsa050330.39159043
135Choline metabolism in cancer_Homo sapiens_hsa052310.38764078
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38603309
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34488510
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34465655
139Metabolic pathways_Homo sapiens_hsa011000.33259505
140Wnt signaling pathway_Homo sapiens_hsa043100.32301227
141Retinol metabolism_Homo sapiens_hsa008300.29857828
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29669901
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28940177
144beta-Alanine metabolism_Homo sapiens_hsa004100.27485013
145RNA polymerase_Homo sapiens_hsa030200.27251377
146Selenocompound metabolism_Homo sapiens_hsa004500.26250619
147Tight junction_Homo sapiens_hsa045300.25728356

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