TRIM28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.21521743
2embryonic process involved in female pregnancy (GO:0060136)6.44316150
3transcription from mitochondrial promoter (GO:0006390)6.38993890
4replication fork processing (GO:0031297)6.23740792
5proline metabolic process (GO:0006560)6.04565818
6establishment of apical/basal cell polarity (GO:0035089)6.01370375
7somatic diversification of immune receptors via somatic mutation (GO:0002566)5.48453647
8somatic hypermutation of immunoglobulin genes (GO:0016446)5.48453647
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.40718382
10positive regulation of protein homooligomerization (GO:0032464)5.32146924
11establishment of monopolar cell polarity (GO:0061162)5.19218889
12establishment or maintenance of monopolar cell polarity (GO:0061339)5.19218889
13DNA deamination (GO:0045006)5.15090584
14regulation of integrin activation (GO:0033623)5.05248989
15mitotic chromosome condensation (GO:0007076)4.81360770
16mitochondrial DNA metabolic process (GO:0032042)4.77202776
17DNA strand renaturation (GO:0000733)4.71404451
18regulation of translational fidelity (GO:0006450)4.70851435
19nuclear pore complex assembly (GO:0051292)4.69537542
20regulation of gene silencing by miRNA (GO:0060964)4.66011176
21regulation of gene silencing by RNA (GO:0060966)4.66011176
22regulation of posttranscriptional gene silencing (GO:0060147)4.66011176
23oxidative demethylation (GO:0070989)4.62875627
24mitotic G1 DNA damage checkpoint (GO:0031571)4.61830547
25regulation of protein homooligomerization (GO:0032462)4.57536922
26spliceosomal tri-snRNP complex assembly (GO:0000244)4.44811129
27formation of translation preinitiation complex (GO:0001731)4.41074435
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.27201356
29viral mRNA export from host cell nucleus (GO:0046784)4.19412810
30mRNA cleavage (GO:0006379)4.16502240
31peptidyl-arginine omega-N-methylation (GO:0035247)4.14222190
32poly(A)+ mRNA export from nucleus (GO:0016973)4.09978871
33G1 DNA damage checkpoint (GO:0044783)4.08718754
34mitotic G1/S transition checkpoint (GO:0044819)4.06814663
35regulation of sister chromatid cohesion (GO:0007063)4.06313335
36telomere maintenance via semi-conservative replication (GO:0032201)4.05683465
37dosage compensation (GO:0007549)4.04779688
38positive regulation of mitotic sister chromatid separation (GO:1901970)3.99343164
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.99343164
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.99343164
41nuclear pore organization (GO:0006999)3.98786024
42protein complex localization (GO:0031503)3.98365050
43base-excision repair (GO:0006284)3.97238442
44embryonic placenta development (GO:0001892)3.96593916
45histone H4-K12 acetylation (GO:0043983)3.90773335
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.89425911
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.87574850
48regulation of RNA export from nucleus (GO:0046831)3.86174039
49negative regulation of JAK-STAT cascade (GO:0046426)3.85340669
50DNA replication initiation (GO:0006270)3.84661658
51negative regulation of mRNA processing (GO:0050686)3.81911212
52planar cell polarity pathway involved in neural tube closure (GO:0090179)3.81741488
53nucleosome disassembly (GO:0006337)3.80594907
54protein-DNA complex disassembly (GO:0032986)3.80594907
55pre-miRNA processing (GO:0031054)3.78230007
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.72323974
57negative regulation of cell cycle arrest (GO:0071157)3.70878629
58DNA strand elongation involved in DNA replication (GO:0006271)3.70758447
59meiotic chromosome segregation (GO:0045132)3.60976709
60DNA integration (GO:0015074)3.60691224
61positive regulation of chromosome segregation (GO:0051984)3.57961551
62double-strand break repair via nonhomologous end joining (GO:0006303)3.56737155
63non-recombinational repair (GO:0000726)3.56737155
64DNA topological change (GO:0006265)3.55190812
65trophectodermal cell differentiation (GO:0001829)3.52600343
66cellular protein complex localization (GO:0034629)3.51057463
67COPI coating of Golgi vesicle (GO:0048205)3.49104709
68Golgi transport vesicle coating (GO:0048200)3.49104709
69termination of RNA polymerase II transcription (GO:0006369)3.48963114
70DNA double-strand break processing (GO:0000729)3.48824334
71apoptotic process involved in morphogenesis (GO:0060561)3.48469307
72DNA strand elongation (GO:0022616)3.48103698
73mitotic sister chromatid segregation (GO:0000070)3.46091309
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.45746518
75peptidyl-arginine methylation (GO:0018216)3.43790799
76peptidyl-arginine N-methylation (GO:0035246)3.43790799
77embryonic camera-type eye development (GO:0031076)3.43070119
78negative regulation of RNA splicing (GO:0033119)3.41160149
79protein localization to chromosome, centromeric region (GO:0071459)3.40762671
80mRNA stabilization (GO:0048255)3.39820260
81RNA stabilization (GO:0043489)3.39820260
82pore complex assembly (GO:0046931)3.38797123
83determination of adult lifespan (GO:0008340)3.36022900
84positive regulation by host of viral transcription (GO:0043923)3.35940510
85DNA duplex unwinding (GO:0032508)3.35561045
86nodal signaling pathway (GO:0038092)3.34555895
87negative regulation of fatty acid biosynthetic process (GO:0045717)3.33696024
88adherens junction assembly (GO:0034333)3.31967766
89negative regulation of Ras GTPase activity (GO:0034261)3.31956137
90regulation of double-strand break repair (GO:2000779)3.31114959
91telomere maintenance via recombination (GO:0000722)3.30916345
92regulation of DNA damage checkpoint (GO:2000001)3.30153976
93activation of Rac GTPase activity (GO:0032863)3.29433387
94regulation of double-strand break repair via homologous recombination (GO:0010569)3.28063209
95mitochondrial RNA metabolic process (GO:0000959)3.26875862
96establishment of integrated proviral latency (GO:0075713)3.25757767
97positive regulation of protein oligomerization (GO:0032461)3.23414382
98regulation of hippo signaling (GO:0035330)3.23026149
99maturation of 5.8S rRNA (GO:0000460)3.20717065
100ribosomal small subunit biogenesis (GO:0042274)3.20546105
101negative regulation of mRNA metabolic process (GO:1903312)3.18399256
102cellular response to ATP (GO:0071318)3.15655555
103chromosome condensation (GO:0030261)3.15253728
104cell-substrate adherens junction assembly (GO:0007045)3.14800302
105focal adhesion assembly (GO:0048041)3.14800302
106glutamine family amino acid biosynthetic process (GO:0009084)3.13975588
107chromatin assembly (GO:0031497)3.12544458
108DNA geometric change (GO:0032392)3.11546406
109pentose-phosphate shunt (GO:0006098)3.09826673
110face development (GO:0060324)3.09381057
1113-UTR-mediated mRNA stabilization (GO:0070935)3.08192616
112kinetochore assembly (GO:0051382)3.08083738
113regulation of translational termination (GO:0006449)3.07368012
114base-excision repair, AP site formation (GO:0006285)3.05340204
115negative regulation of cell size (GO:0045792)3.05247347
116anterior/posterior axis specification, embryo (GO:0008595)3.04778181
117sister chromatid segregation (GO:0000819)3.03798425
118histone arginine methylation (GO:0034969)3.02213304
119negative regulation of protein oligomerization (GO:0032460)3.01675461
120heterochromatin organization (GO:0070828)3.01300659
121regulation of chromatin binding (GO:0035561)3.00554939
122regulation of NFAT protein import into nucleus (GO:0051532)3.00368396
123DNA ligation (GO:0006266)3.00040870
124regulation of protein oligomerization (GO:0032459)2.99449235
125protein localization to kinetochore (GO:0034501)2.98331663
126mitotic nuclear envelope disassembly (GO:0007077)2.98313602
127anatomical structure regression (GO:0060033)2.95439318
128mitotic recombination (GO:0006312)2.95047054
129mitotic sister chromatid cohesion (GO:0007064)2.94904744
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94652933
131rRNA transcription (GO:0009303)2.94558642
132telomere maintenance via telomere lengthening (GO:0010833)2.93323636
133protein export from nucleus (GO:0006611)2.92969212
134paraxial mesoderm development (GO:0048339)2.92774191
135maternal placenta development (GO:0001893)2.91620118
136mRNA export from nucleus (GO:0006406)2.91584494
137regulation of nucleobase-containing compound transport (GO:0032239)2.91294768
138positive regulation of developmental pigmentation (GO:0048087)2.91247646
139mRNA transport (GO:0051028)2.89479698
140DNA conformation change (GO:0071103)2.89007500
141labyrinthine layer development (GO:0060711)2.88271587
142protein retention in ER lumen (GO:0006621)2.87662902
143DNA unwinding involved in DNA replication (GO:0006268)2.86648161
144resolution of meiotic recombination intermediates (GO:0000712)2.86095477
145membrane disassembly (GO:0030397)2.86084231
146nuclear envelope disassembly (GO:0051081)2.86084231
147intracellular estrogen receptor signaling pathway (GO:0030520)2.85764261
148L-serine metabolic process (GO:0006563)2.84509956
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81954419
150negative regulation of histone methylation (GO:0031061)2.80224323
151NADPH regeneration (GO:0006740)2.73255201
152glucose catabolic process (GO:0006007)2.71708865
153cellular response to epidermal growth factor stimulus (GO:0071364)2.65258765
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.60786460
155positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60565105
156glucocorticoid receptor signaling pathway (GO:0042921)2.60181342
157regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59803594
158folic acid-containing compound biosynthetic process (GO:0009396)2.59766961
159retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59724352
160regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59363984
161regulation of early endosome to late endosome transport (GO:2000641)2.58063866
162epithelial cell-cell adhesion (GO:0090136)2.57790610
163DNA packaging (GO:0006323)2.56338135
164mitotic metaphase plate congression (GO:0007080)2.55647715
165negative regulation of cell fate specification (GO:0009996)2.55377952
166DNA synthesis involved in DNA repair (GO:0000731)2.55160912
167maturation of SSU-rRNA (GO:0030490)2.54227381
168regulation of mRNA stability (GO:0043488)2.53792725
169nuclear envelope organization (GO:0006998)2.53608339
170positive regulation of DNA-dependent DNA replication (GO:2000105)2.53571294
171cytoskeletal anchoring at plasma membrane (GO:0007016)2.50758146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.26321098
2* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.37667554
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.33614340
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.27196406
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.27196406
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.27196406
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13728613
8* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.92798228
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68774942
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49747984
11* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.44210218
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40811994
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.39077690
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.35463674
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.32324454
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19273041
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14410634
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12605498
19* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.12048620
20KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.11875692
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11816338
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.11195639
23VDR_21846776_ChIP-Seq_THP-1_Human2.05122184
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03579434
25POU5F1_16518401_ChIP-PET_MESCs_Mouse2.02907251
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02017891
27STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01455580
28TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01419957
29MYC_22102868_ChIP-Seq_BL_Human1.94610882
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93557757
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93179681
32* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.89374527
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89183055
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.77386526
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75797849
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75701562
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67150900
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65660654
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62106457
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.60556090
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60526638
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60410039
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.58763862
44ZNF263_19887448_ChIP-Seq_K562_Human1.58571239
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54801153
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53612686
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50412603
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47995331
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47562220
50* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44943218
51* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44846549
52NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44655612
53AR_21909140_ChIP-Seq_LNCAP_Human1.41285426
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40854380
55LXR_22292898_ChIP-Seq_THP-1_Human1.39432191
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38825600
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38666538
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.38616359
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38044566
60XRN2_22483619_ChIP-Seq_HELA_Human1.37864533
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37128379
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37026128
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36928210
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35727052
65* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.34832633
66* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34405872
67* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33266440
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.32930160
69KDM2B_26808549_Chip-Seq_K562_Human1.29930832
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29370095
71NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28282066
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.27560788
73* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27091955
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26796864
75KDM5A_27292631_Chip-Seq_BREAST_Human1.26539071
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24955205
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24207183
78P68_20966046_ChIP-Seq_HELA_Human1.23668847
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22716386
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22172320
81CLOCK_20551151_ChIP-Seq_293T_Human1.21022508
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20822420
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20717866
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19607773
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.19440534
86* GABP_19822575_ChIP-Seq_HepG2_Human1.18605697
87NCOR1_26117541_ChIP-Seq_K562_Human1.18595550
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18221339
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18195608
90TTF2_22483619_ChIP-Seq_HELA_Human1.17685823
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17591473
92* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17095244
93* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16355476
94* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16132928
95ATF3_27146783_Chip-Seq_COLON_Human1.16028598
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14984573
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14323995
98RACK7_27058665_Chip-Seq_MCF-7_Human1.14321037
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12849862
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12105200
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11557131
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11403516
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.11387054
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11189117
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10331542
106CREB1_26743006_Chip-Seq_LNCaP_Human1.09763019
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09701859
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09608984
109PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09355303
110* KDM2B_26808549_Chip-Seq_DND41_Human1.09094254
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08968569
112* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08938991
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08918970
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.08517212
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08422922
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08220874
117* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07917123
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07853801
119* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07166946
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05648329
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05384224
122* KDM2B_26808549_Chip-Seq_JURKAT_Human1.04152693
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01320381
124* DCP1A_22483619_ChIP-Seq_HELA_Human1.01282965
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.01223865
126KAP1_27257070_Chip-Seq_ESCs_Mouse1.01112098
127CIITA_25753668_ChIP-Seq_RAJI_Human1.01080773
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00453782
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99022083
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98945005
131CHD1_26751641_Chip-Seq_LNCaP_Human0.98169337
132MAF_26560356_Chip-Seq_TH1_Human0.97857154
133ELK3_25401928_ChIP-Seq_HUVEC_Human0.97735688
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.97206671
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96047552
136SMC4_20622854_ChIP-Seq_HELA_Human0.95634926
137TP53_22127205_ChIP-Seq_IMR90_Human0.94881730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.89584212
2MP0009278_abnormal_bone_marrow3.69000947
3MP0010030_abnormal_orbit_morphology3.62278607
4MP0010094_abnormal_chromosome_stability3.23402791
5MP0005171_absent_coat_pigmentation3.05730215
6MP0004233_abnormal_muscle_weight2.99993144
7MP0004957_abnormal_blastocyst_morpholog2.87228405
8MP0003111_abnormal_nucleus_morphology2.68143386
9MP0010234_abnormal_vibrissa_follicle2.60919908
10MP0004185_abnormal_adipocyte_glucose2.51898126
11MP0003890_abnormal_embryonic-extraembry2.47305104
12MP0003283_abnormal_digestive_organ2.38288159
13MP0010352_gastrointestinal_tract_polyps2.35381206
14MP0002653_abnormal_ependyma_morphology2.33612241
15MP0004133_heterotaxia2.24143550
16MP0002009_preneoplasia2.23095907
17MP0005076_abnormal_cell_differentiation2.22614941
18MP0003119_abnormal_digestive_system2.21156163
19MP0003693_abnormal_embryo_hatching2.18720488
20MP0002877_abnormal_melanocyte_morpholog2.17492445
21MP0003077_abnormal_cell_cycle2.16029554
22MP0009672_abnormal_birth_weight2.14079006
23MP0008058_abnormal_DNA_repair2.08141542
24MP0008995_early_reproductive_senescence2.06159128
25MP0004858_abnormal_nervous_system2.00835576
26MP0005451_abnormal_body_composition1.99224194
27MP0003786_premature_aging1.99079512
28MP0008877_abnormal_DNA_methylation1.96642889
29* MP0002084_abnormal_developmental_patter1.93260851
30MP0000566_synostosis1.89081143
31MP0008932_abnormal_embryonic_tissue1.88556681
32MP0004197_abnormal_fetal_growth/weight/1.88383116
33MP0001697_abnormal_embryo_size1.87629940
34MP0001293_anophthalmia1.84443615
35* MP0002086_abnormal_extraembryonic_tissu1.83480054
36* MP0002085_abnormal_embryonic_tissue1.82757518
37MP0001545_abnormal_hematopoietic_system1.82431547
38MP0005397_hematopoietic_system_phenotyp1.82431547
39MP0002249_abnormal_larynx_morphology1.77749250
40MP0001730_embryonic_growth_arrest1.76149292
41MP0001672_abnormal_embryogenesis/_devel1.71892255
42MP0005380_embryogenesis_phenotype1.71892255
43MP0000350_abnormal_cell_proliferation1.69939844
44MP0003567_abnormal_fetal_cardiomyocyte1.64604634
45MP0006072_abnormal_retinal_apoptosis1.64578902
46MP0002282_abnormal_trachea_morphology1.58812701
47MP0000678_abnormal_parathyroid_gland1.55240160
48MP0002396_abnormal_hematopoietic_system1.50441849
49MP0002089_abnormal_postnatal_growth/wei1.46254176
50MP0003453_abnormal_keratinocyte_physiol1.45388108
51MP0000490_abnormal_crypts_of1.44085593
52MP0010307_abnormal_tumor_latency1.42934977
53MP0002254_reproductive_system_inflammat1.39958734
54MP0003984_embryonic_growth_retardation1.39827004
55MP0005257_abnormal_intraocular_pressure1.36865434
56MP0005174_abnormal_tail_pigmentation1.35718235
57MP0002088_abnormal_embryonic_growth/wei1.35679577
58* MP0002080_prenatal_lethality1.33192123
59MP0001348_abnormal_lacrimal_gland1.30936989
60MP0004808_abnormal_hematopoietic_stem1.29798211
61MP0008260_abnormal_autophagy1.29604683
62MP0002111_abnormal_tail_morphology1.29389331
63MP0005666_abnormal_adipose_tissue1.28233863
64MP0009053_abnormal_anal_canal1.24691686
65MP0000371_diluted_coat_color1.19268492
66MP0003705_abnormal_hypodermis_morpholog1.18981992
67MP0000428_abnormal_craniofacial_morphol1.18583127
68MP0003942_abnormal_urinary_system1.18397510
69MP0005623_abnormal_meninges_morphology1.18284470
70MP0004272_abnormal_basement_membrane1.17849315
71MP0003315_abnormal_perineum_morphology1.16711067
72MP0000462_abnormal_digestive_system1.12756064
73MP0000733_abnormal_muscle_development1.11300635
74MP0004264_abnormal_extraembryonic_tissu1.10281248
75MP0001346_abnormal_lacrimal_gland1.09898167
76MP0003115_abnormal_respiratory_system1.09866316
77MP0000003_abnormal_adipose_tissue1.09674641
78MP0000470_abnormal_stomach_morphology1.08598919
79MP0002019_abnormal_tumor_incidence1.06937647
80MP0002269_muscular_atrophy1.06276819
81MP0005409_darkened_coat_color1.05129719
82MP0005058_abnormal_lysosome_morphology1.04501419
83MP0001661_extended_life_span1.03378417
84MP0000579_abnormal_nail_morphology1.02273834
85MP0005621_abnormal_cell_physiology1.02090765
86MP0002796_impaired_skin_barrier1.02012307
87MP0005375_adipose_tissue_phenotype1.01072566
88MP0002932_abnormal_joint_morphology1.00530609
89MP0003935_abnormal_craniofacial_develop1.00157393
90MP0003941_abnormal_skin_development0.99375746
91MP0002060_abnormal_skin_morphology0.98511976
92MP0001340_abnormal_eyelid_morphology0.96269219
93MP0003755_abnormal_palate_morphology0.95354235
94MP0000313_abnormal_cell_death0.94609902
95MP0008438_abnormal_cutaneous_collagen0.93813548
96MP0003718_maternal_effect0.93543943
97MP0001145_abnormal_male_reproductive0.91722939
98MP0008007_abnormal_cellular_replicative0.91596264
99MP0002114_abnormal_axial_skeleton0.91018019
100MP0003566_abnormal_cell_adhesion0.90784145
101MP0000432_abnormal_head_morphology0.89903707
102MP0000762_abnormal_tongue_morphology0.87301135
103MP0005367_renal/urinary_system_phenotyp0.86943700
104MP0000516_abnormal_urinary_system0.86943700
105MP0002098_abnormal_vibrissa_morphology0.86585716
106MP0001216_abnormal_epidermal_layer0.86467284
107MP0002697_abnormal_eye_size0.86174156
108MP0002075_abnormal_coat/hair_pigmentati0.85305502
109MP0003091_abnormal_cell_migration0.84741621
110MP0000858_altered_metastatic_potential0.84698429
111MP0000534_abnormal_ureter_morphology0.82803064
112MP0005384_cellular_phenotype0.82597389
113MP0005501_abnormal_skin_physiology0.82517366
114MP0003172_abnormal_lysosome_physiology0.82102387
115MP0002116_abnormal_craniofacial_bone0.81061067
116MP0002210_abnormal_sex_determination0.78652339
117MP0003937_abnormal_limbs/digits/tail_de0.77771313
118MP0000467_abnormal_esophagus_morphology0.77567597
119MP0005266_abnormal_metabolism0.77407043
120MP0000377_abnormal_hair_follicle0.76620003
121MP0003861_abnormal_nervous_system0.76388067
122MP0009931_abnormal_skin_appearance0.76238630
123MP0003385_abnormal_body_wall0.74484956
124MP0003123_paternal_imprinting0.73165906
125MP0005075_abnormal_melanosome_morpholog0.73134541
126MP0002092_abnormal_eye_morphology0.73083995
127MP0009379_abnormal_foot_pigmentation0.71348136
128MP0005023_abnormal_wound_healing0.70656450
129MP0000639_abnormal_adrenal_gland0.69923407
130MP0000537_abnormal_urethra_morphology0.69744647
131MP0003828_pulmonary_edema0.69525576
132MP0000477_abnormal_intestine_morphology0.69457382
133MP0003136_yellow_coat_color0.69446244
134MP0001849_ear_inflammation0.66952768
135MP0002925_abnormal_cardiovascular_devel0.66647787
136MP0000653_abnormal_sex_gland0.66527646
137MP0000015_abnormal_ear_pigmentation0.66448191
138MP0003936_abnormal_reproductive_system0.66014855
139MP0001929_abnormal_gametogenesis0.65980665
140MP0009703_decreased_birth_body0.65797317
141MP0001915_intracranial_hemorrhage0.63948579
142MP0010630_abnormal_cardiac_muscle0.63933593

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.40769179
2Facial hemangioma (HP:0000329)4.79745407
3Rectovaginal fistula (HP:0000143)4.48882374
4Rectal fistula (HP:0100590)4.48882374
5Annular pancreas (HP:0001734)4.43066640
6Concave nail (HP:0001598)4.25996263
7Intestinal fistula (HP:0100819)4.08128657
8Ulnar bowing (HP:0003031)3.93961812
9Hyperacusis (HP:0010780)3.93736323
10Short humerus (HP:0005792)3.93489620
11Vaginal fistula (HP:0004320)3.92768725
12Aplasia/hypoplasia of the humerus (HP:0006507)3.84310148
13Turricephaly (HP:0000262)3.83262081
14Poikiloderma (HP:0001029)3.81491314
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.76627168
16Pustule (HP:0200039)3.74004224
17Absent radius (HP:0003974)3.62417987
18Hypochromic microcytic anemia (HP:0004840)3.42571232
19Alopecia of scalp (HP:0002293)3.42331121
20Aplasia involving forearm bones (HP:0009822)3.41138718
21Absent forearm bone (HP:0003953)3.41138718
22Selective tooth agenesis (HP:0001592)3.38840238
23Tongue fasciculations (HP:0001308)3.35478509
24Orthostatic hypotension (HP:0001278)3.35051000
25Intestinal atresia (HP:0011100)3.32976775
26Increased IgM level (HP:0003496)3.32100671
27Abnormality of the labia minora (HP:0012880)3.28142532
28Coronal craniosynostosis (HP:0004440)3.26534220
29Basal cell carcinoma (HP:0002671)3.21191458
30Abnormality of the astrocytes (HP:0100707)3.19532029
31Astrocytoma (HP:0009592)3.19532029
32Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.19093343
33Vertebral hypoplasia (HP:0008417)3.19093343
34Absent thumb (HP:0009777)3.14289510
35Ependymoma (HP:0002888)3.11486774
36Muscle fibrillation (HP:0010546)3.10508718
37Male infertility (HP:0003251)3.04638286
38Patellar aplasia (HP:0006443)3.01599795
39Squamous cell carcinoma (HP:0002860)2.98224880
40Broad alveolar ridges (HP:0000187)2.90879140
41Volvulus (HP:0002580)2.85890369
42Abnormal hemoglobin (HP:0011902)2.84908545
43Neoplasm of the oral cavity (HP:0100649)2.84258114
44Anteriorly placed anus (HP:0001545)2.82883643
45Congenital hip dislocation (HP:0001374)2.80076564
46Aplasia/Hypoplasia of the patella (HP:0006498)2.77827602
47Short chin (HP:0000331)2.74239369
48Insomnia (HP:0100785)2.70910596
49Alacrima (HP:0000522)2.70301696
50Broad distal phalanx of finger (HP:0009836)2.68941773
51Long palpebral fissure (HP:0000637)2.61442091
52Broad face (HP:0000283)2.56300334
53Vertebral fusion (HP:0002948)2.55297188
54Abnormality of the aortic arch (HP:0012303)2.52484275
55Disproportionate tall stature (HP:0001519)2.51495082
56Dysautonomia (HP:0002459)2.48546800
57Gastrointestinal atresia (HP:0002589)2.48071049
58Abnormal number of incisors (HP:0011064)2.45762669
59Shallow orbits (HP:0000586)2.44941746
60Glioma (HP:0009733)2.44836164
61Abnormality of male internal genitalia (HP:0000022)2.41570917
62Hamartoma (HP:0010566)2.40212024
63Premature graying of hair (HP:0002216)2.39836243
64Trismus (HP:0000211)2.38900810
65Distal lower limb amyotrophy (HP:0008944)2.38889858
66Progressive muscle weakness (HP:0003323)2.37722320
67Deviation of the thumb (HP:0009603)2.37493628
68Cerebral aneurysm (HP:0004944)2.37323000
69Increased nuchal translucency (HP:0010880)2.37296789
70Abnormality of the distal phalanx of the thumb (HP:0009617)2.34259186
71High anterior hairline (HP:0009890)2.31881620
72Premature rupture of membranes (HP:0001788)2.31673343
73Hypotelorism (HP:0000601)2.31496703
74Achilles tendon contracture (HP:0001771)2.29518114
75Choanal stenosis (HP:0000452)2.29136197
76Acute lymphatic leukemia (HP:0006721)2.25300477
77Proximal placement of thumb (HP:0009623)2.25282713
78Bowed forearm bones (HP:0003956)2.22790404
79Bowing of the arm (HP:0006488)2.22790404
80Hypotrichosis (HP:0001006)2.20039612
81Pancreatic islet-cell hyperplasia (HP:0004510)2.18636285
82Overriding aorta (HP:0002623)2.18326297
83Asymmetry of the thorax (HP:0001555)2.16823487
84Premature skin wrinkling (HP:0100678)2.16781698
85Dysmetric saccades (HP:0000641)2.14594952
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14495312
87Abnormality of the lower motor neuron (HP:0002366)2.13416778
88Rhabdomyosarcoma (HP:0002859)2.12987823
89Hypoplasia of the radius (HP:0002984)2.12700887
90Flat acetabular roof (HP:0003180)2.11488451
91Ankyloglossia (HP:0010296)2.11291151
92Missing ribs (HP:0000921)2.10367884
93Capillary hemangiomas (HP:0005306)2.09926756
94Medulloblastoma (HP:0002885)2.09880448
95Abnormality of the calcaneus (HP:0008364)2.07940058
96Decreased lacrimation (HP:0000633)2.06696041
97Shawl scrotum (HP:0000049)2.05496518
98Split hand (HP:0001171)2.04971414
99Spinal muscular atrophy (HP:0007269)2.03640198
100Albinism (HP:0001022)2.03169369
101Large for gestational age (HP:0001520)2.03145244
102Patellar dislocation (HP:0002999)2.02186702
103Urethral obstruction (HP:0000796)2.01699780
104Pointed chin (HP:0000307)2.01604973
105Bifid uvula (HP:0000193)2.01252657
106Hemivertebrae (HP:0002937)2.01210824
107Abnormality of abdominal situs (HP:0011620)2.00434894
108Abdominal situs inversus (HP:0003363)2.00434894
109Hypochromic anemia (HP:0001931)2.00220416
110Protrusio acetabuli (HP:0003179)1.99595942
111Diaphragmatic weakness (HP:0009113)1.99503315
112Deep palmar crease (HP:0006191)1.98287382
113Short thumb (HP:0009778)1.98103387
114Arnold-Chiari malformation (HP:0002308)1.97789084
115Upper limb amyotrophy (HP:0009129)1.97503793
116Distal upper limb amyotrophy (HP:0007149)1.97503793
117Increased number of teeth (HP:0011069)1.97290753
118Abnormality of the ileum (HP:0001549)1.96522697
119Abnormality of oral frenula (HP:0000190)1.96185063
120Short 5th finger (HP:0009237)1.95947216
121Elfin facies (HP:0004428)1.95859198
122Biconcave vertebral bodies (HP:0004586)1.95768577
123Abnormality of the Achilles tendon (HP:0005109)1.94935508
124Breast hypoplasia (HP:0003187)1.94697470
125Esophageal atresia (HP:0002032)1.94392463
126Renal duplication (HP:0000075)1.94192317
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.93583255
128Spastic diplegia (HP:0001264)1.93123979
129Increased connective tissue (HP:0009025)1.92420849
130Neoplasm of striated muscle (HP:0009728)1.90449159
131Abnormality of the fingertips (HP:0001211)1.88100510
132Aplasia of the musculature (HP:0100854)1.87973283
133IgA deficiency (HP:0002720)1.87184614
134Broad thumb (HP:0011304)1.87030960
135Progressive external ophthalmoplegia (HP:0000590)1.86430309
136Truncus arteriosus (HP:0001660)1.86263835
137Back pain (HP:0003418)1.86118673
138Septate vagina (HP:0001153)1.85884273
139Thin ribs (HP:0000883)1.84676976
140Lower limb amyotrophy (HP:0007210)1.84423007
141Metaphyseal cupping (HP:0003021)1.83355548
142Advanced eruption of teeth (HP:0006288)1.81357912
143Pseudobulbar signs (HP:0002200)1.80894611
144Chromsome breakage (HP:0040012)1.80558176
145Skull defect (HP:0001362)1.80401710
146Duplication of thumb phalanx (HP:0009942)1.79280876
147Urinary glycosaminoglycan excretion (HP:0003541)1.79064126
148Mucopolysacchariduria (HP:0008155)1.79064126
149Abnormality of the thoracic spine (HP:0100711)1.78576016
150Joint stiffness (HP:0001387)1.77757732
151Abnormality of the distal phalanges of the toes (HP:0010182)1.77268503
152Reticulocytopenia (HP:0001896)1.77015457
153Atresia of the external auditory canal (HP:0000413)1.76933892
154Abnormality of the salivary glands (HP:0010286)1.76566021
155Trigonocephaly (HP:0000243)1.76429897
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76195337
157Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75835673
158Partial duplication of thumb phalanx (HP:0009944)1.75400737
159Heterotopia (HP:0002282)1.74663268
160Vertebral clefting (HP:0008428)1.74138053
161Abnormality of reticulocytes (HP:0004312)1.73627987
162Hypoplasia of the ulna (HP:0003022)1.73545098
163Abnormality of the umbilical cord (HP:0010881)1.72546501
164Abnormality of the phalanges of the hallux (HP:0010057)1.72431583
165Reticulocytosis (HP:0001923)1.72023395
166Abnormal gallbladder physiology (HP:0012438)1.71642317
167Cholecystitis (HP:0001082)1.71642317
168Midface retrusion (HP:0011800)1.70128033
169Flared metaphyses (HP:0003015)1.69541741
170Multiple enchondromatosis (HP:0005701)1.69321253
171Syringomyelia (HP:0003396)1.68745437
172Spinal cord lesions (HP:0100561)1.68745437
173Stridor (HP:0010307)1.67326071
174Long eyelashes (HP:0000527)1.66770592
175Bronchomalacia (HP:0002780)1.65816395
176Glossoptosis (HP:0000162)1.65670817
177Bowel incontinence (HP:0002607)1.64376846
178Myopathic facies (HP:0002058)1.64039515
179Genu recurvatum (HP:0002816)1.61786596
180Fragile skin (HP:0001030)1.60947438
181Microvesicular hepatic steatosis (HP:0001414)1.60722519
182Difficulty climbing stairs (HP:0003551)1.60090699
183Overlapping toe (HP:0001845)1.60089612
184Short nail (HP:0001799)1.59753928
185Obstructive sleep apnea (HP:0002870)1.59564857
186Partial duplication of the phalanx of hand (HP:0009999)1.58304450
187Vertebral compression fractures (HP:0002953)1.58168887
188Abnormal large intestine physiology (HP:0012700)1.57832507
189Germ cell neoplasia (HP:0100728)1.56678263
190Uterine leiomyosarcoma (HP:0002891)1.55687953
191Leiomyosarcoma (HP:0100243)1.55687953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.92876563
2SMG15.02297240
3DDR24.52489281
4MAP3K64.08420937
5MAPK153.98281142
6TYRO32.92772889
7MAP3K112.88629810
8SIK12.73252789
9FGR2.59170250
10MATK2.55896485
11PINK12.40564171
12IRAK32.30248412
13BMX2.20862991
14DAPK12.18229408
15NME22.16674979
16CDK72.15990016
17PDGFRA2.09028144
18UHMK12.04882084
19CDK121.98090884
20PRKD21.82405620
21YES11.79176696
22CSK1.76212403
23DYRK1B1.70456156
24LATS21.67655081
25CDC71.63070631
26TTN1.59923750
27VRK21.58963348
28EPHA21.58829418
29CDK61.58215251
30PIM21.55672201
31FGFR41.52953564
32PKN21.52484042
33AKT31.50053854
34WEE11.48535504
35MAP3K101.48522066
36PIM11.46959740
37RPS6KB21.32808767
38PLK11.29698981
39TAF11.29114449
40NEK21.28473021
41MST1R1.23749514
42DYRK31.18118905
43TRPM71.17055367
44RPS6KC11.16361237
45RPS6KL11.16361237
46ERN11.13069559
47BUB11.11227293
48CAMK1D1.05799723
49MTOR1.05119706
50PRKD31.04160091
51PTK61.02883540
52ATR1.01575312
53NEK10.98958766
54CDC42BPA0.98652751
55RPS6KA60.98565154
56GSK3A0.97978213
57LMTK20.92131821
58MAPK110.91456393
59TTK0.90434510
60BRAF0.89702475
61TSSK60.89171860
62PTK20.87382756
63ARAF0.81263315
64ALK0.80199749
65MAP2K20.79747826
66SRPK10.79488979
67CDK20.78865896
68CDK40.78023237
69KSR20.77659575
70EEF2K0.76134507
71LATS10.73121509
72CAMK1G0.72667943
73RPS6KA10.71946468
74MAP2K30.68232343
75CDK90.68201390
76PHKG20.67809096
77PHKG10.67809096
78AURKA0.67184172
79IRAK20.64231004
80RPS6KA20.63769577
81TRIB30.63724596
82MET0.63084418
83CDK80.62352220
84AURKB0.62262180
85* CHEK10.60375973
86STK30.58242444
87NTRK10.57056628
88BRSK10.56501432
89PBK0.55264476
90KDR0.55245362
91TLK10.55086035
92PRKAA10.55071656
93TESK10.54726057
94TAOK20.52519921
95MAP3K130.52314652
96LRRK20.50628600
97HIPK20.50124238
98PAK40.49822331
99CSNK2A10.48397519
100ILK0.48267664
101* ATM0.47838281
102CLK10.47806490
103CDK10.47478449
104MARK20.47321602
105RPS6KB10.47300073
106MAP3K80.47031527
107* CHEK20.46516995
108CSNK2A20.46400184
109TAOK10.46159687
110MAPK10.44679217
111CDK11A0.44439373
112FLT30.44210509
113PAK20.44178886
114RIPK10.43768350
115RAF10.43636444
116EGFR0.41980237
117MAPK140.41697009
118PRPF4B0.40897637
119BRD40.40536557
120PDGFRB0.39055188
121CDK150.38893879
122FGFR10.38009831
123PRKG20.37951431
124MAP3K90.36468000
125MELK0.35878355
126TESK20.35050374
127MAP3K10.34351521
128RPS6KA40.34208853
129STK100.33936169
130CSNK1G10.33932353
131MAPK100.33822837
132PDPK10.33252776
133CDK180.33193517
134CSNK1E0.32579093
135MAPKAPK30.32573286
136ERBB30.32141226
137DMPK0.31802938
138MAPK30.31715933
139PRKCI0.31532908
140PAK10.31113032
141MKNK20.31052990
142PASK0.30113120
143DYRK20.29702447
144STK38L0.29160656
145PRKDC0.28902474
146SCYL20.28544899
147AKT20.27277329
148GSK3B0.27058155
149STK40.25896612

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.21442084
2DNA replication_Homo sapiens_hsa030304.39946442
3Base excision repair_Homo sapiens_hsa034104.33399326
4Fatty acid biosynthesis_Homo sapiens_hsa000613.96748741
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92040466
6Spliceosome_Homo sapiens_hsa030402.79335867
7RNA transport_Homo sapiens_hsa030132.76434746
8Nucleotide excision repair_Homo sapiens_hsa034202.63898474
9mRNA surveillance pathway_Homo sapiens_hsa030152.38988534
10Homologous recombination_Homo sapiens_hsa034402.17929120
11Cell cycle_Homo sapiens_hsa041102.07319434
12Fanconi anemia pathway_Homo sapiens_hsa034601.99811802
13Hippo signaling pathway_Homo sapiens_hsa043901.95941237
14Pentose phosphate pathway_Homo sapiens_hsa000301.93299948
15Notch signaling pathway_Homo sapiens_hsa043301.90024586
16Hedgehog signaling pathway_Homo sapiens_hsa043401.85582475
17mTOR signaling pathway_Homo sapiens_hsa041501.83018774
18One carbon pool by folate_Homo sapiens_hsa006701.75482534
19p53 signaling pathway_Homo sapiens_hsa041151.73593971
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70609286
21Non-small cell lung cancer_Homo sapiens_hsa052231.58250813
22Adherens junction_Homo sapiens_hsa045201.57965689
23Biosynthesis of amino acids_Homo sapiens_hsa012301.53802997
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52130507
25Basal cell carcinoma_Homo sapiens_hsa052171.51177200
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40186734
27Pancreatic cancer_Homo sapiens_hsa052121.33952123
28TGF-beta signaling pathway_Homo sapiens_hsa043501.33687671
29Arginine and proline metabolism_Homo sapiens_hsa003301.32273074
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30736948
31Ribosome_Homo sapiens_hsa030101.30110553
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27378926
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25185968
34Bladder cancer_Homo sapiens_hsa052191.22621653
35Oocyte meiosis_Homo sapiens_hsa041141.22424956
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21889536
37Circadian rhythm_Homo sapiens_hsa047101.20098767
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18797136
39Carbon metabolism_Homo sapiens_hsa012001.16124519
40Sulfur relay system_Homo sapiens_hsa041221.15858811
41Wnt signaling pathway_Homo sapiens_hsa043101.13098618
42Lysine degradation_Homo sapiens_hsa003101.12896775
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10966850
44Glioma_Homo sapiens_hsa052141.08593323
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06803953
46MicroRNAs in cancer_Homo sapiens_hsa052061.05005575
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04708300
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03434434
49Colorectal cancer_Homo sapiens_hsa052101.00074815
50Prion diseases_Homo sapiens_hsa050200.98856371
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96619678
52Vitamin B6 metabolism_Homo sapiens_hsa007500.93016763
53Renal cell carcinoma_Homo sapiens_hsa052110.92613307
54RNA degradation_Homo sapiens_hsa030180.91102693
55Viral carcinogenesis_Homo sapiens_hsa052030.91053727
56RNA polymerase_Homo sapiens_hsa030200.90579732
57Other glycan degradation_Homo sapiens_hsa005110.88185916
58Folate biosynthesis_Homo sapiens_hsa007900.87596765
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.85226976
60Shigellosis_Homo sapiens_hsa051310.83171462
61Tight junction_Homo sapiens_hsa045300.82669295
62N-Glycan biosynthesis_Homo sapiens_hsa005100.80534260
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79129379
64Fructose and mannose metabolism_Homo sapiens_hsa000510.78607836
65Apoptosis_Homo sapiens_hsa042100.78398510
66Basal transcription factors_Homo sapiens_hsa030220.76744069
67VEGF signaling pathway_Homo sapiens_hsa043700.76050016
68B cell receptor signaling pathway_Homo sapiens_hsa046620.72245816
69Thyroid cancer_Homo sapiens_hsa052160.72216603
70Small cell lung cancer_Homo sapiens_hsa052220.71315173
71Chronic myeloid leukemia_Homo sapiens_hsa052200.70222195
72Pyrimidine metabolism_Homo sapiens_hsa002400.68232658
73Melanoma_Homo sapiens_hsa052180.67301540
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65475065
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61858096
76Fatty acid metabolism_Homo sapiens_hsa012120.61700675
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.60436935
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60378552
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60243099
80Alcoholism_Homo sapiens_hsa050340.59095944
81Viral myocarditis_Homo sapiens_hsa054160.58459940
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58246890
83Epstein-Barr virus infection_Homo sapiens_hsa051690.57787649
84Non-homologous end-joining_Homo sapiens_hsa034500.56886554
85HTLV-I infection_Homo sapiens_hsa051660.56842707
86Systemic lupus erythematosus_Homo sapiens_hsa053220.56773448
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56450162
88Dorso-ventral axis formation_Homo sapiens_hsa043200.56424639
89Inositol phosphate metabolism_Homo sapiens_hsa005620.56332977
90Melanogenesis_Homo sapiens_hsa049160.55491646
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55406220
92Estrogen signaling pathway_Homo sapiens_hsa049150.54978430
93Selenocompound metabolism_Homo sapiens_hsa004500.54615973
94AMPK signaling pathway_Homo sapiens_hsa041520.53231587
95Proteasome_Homo sapiens_hsa030500.50871194
96Acute myeloid leukemia_Homo sapiens_hsa052210.50341689
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49828332
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49690440
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.47841414
100Hepatitis C_Homo sapiens_hsa051600.47604763
101Proteoglycans in cancer_Homo sapiens_hsa052050.47238120
102Prolactin signaling pathway_Homo sapiens_hsa049170.46294382
103Primary immunodeficiency_Homo sapiens_hsa053400.44732279
104Endometrial cancer_Homo sapiens_hsa052130.44670158
105Herpes simplex infection_Homo sapiens_hsa051680.44444930
106ErbB signaling pathway_Homo sapiens_hsa040120.44151916
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.43991282
108Vibrio cholerae infection_Homo sapiens_hsa051100.43456517
109Legionellosis_Homo sapiens_hsa051340.42853570
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.42269818
111Arginine biosynthesis_Homo sapiens_hsa002200.41054107
112Gap junction_Homo sapiens_hsa045400.40221694
113Pathways in cancer_Homo sapiens_hsa052000.40094044
114Insulin signaling pathway_Homo sapiens_hsa049100.39992822
115Choline metabolism in cancer_Homo sapiens_hsa052310.35954150
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.35205420
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32431379
118Prostate cancer_Homo sapiens_hsa052150.32424323
119Galactose metabolism_Homo sapiens_hsa000520.31570335
120Glutathione metabolism_Homo sapiens_hsa004800.31129750
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28551402
122Focal adhesion_Homo sapiens_hsa045100.27957192
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26176698
124HIF-1 signaling pathway_Homo sapiens_hsa040660.25883876
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25782098
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22620771
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22259246
128MAPK signaling pathway_Homo sapiens_hsa040100.21421522
129Hepatitis B_Homo sapiens_hsa051610.20941619
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.20228840
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17739927

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