TRIM25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29631418
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29631418
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26663851
4negative regulation of cell killing (GO:0031342)4.26663851
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22474902
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.22474902
7modulation by symbiont of host immune response (GO:0052553)4.22474902
8positive regulation by symbiont of host defense response (GO:0052509)4.22474902
9modulation by symbiont of host defense response (GO:0052031)4.22474902
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22474902
11detection of other organism (GO:0098543)4.05157946
12positive regulation of interferon-alpha production (GO:0032727)3.99234037
13antigen processing and presentation of endogenous antigen (GO:0019883)3.95411354
14detection of bacterium (GO:0016045)3.82296461
15regulation of interferon-alpha production (GO:0032647)3.77710735
16regulation of interferon-beta biosynthetic process (GO:0045357)3.71184063
17detection of external biotic stimulus (GO:0098581)3.64948685
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.61939687
19positive regulation of gamma-delta T cell activation (GO:0046645)3.59622220
20germinal center formation (GO:0002467)3.55464778
21regulation of cholesterol storage (GO:0010885)3.51954551
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40045945
23low-density lipoprotein particle clearance (GO:0034383)3.30302809
24interferon-gamma-mediated signaling pathway (GO:0060333)3.24993775
25leukocyte aggregation (GO:0070486)3.23656575
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21328273
27NIK/NF-kappaB signaling (GO:0038061)3.20577673
28negative regulation of erythrocyte differentiation (GO:0045647)3.16460804
29detection of biotic stimulus (GO:0009595)3.15650890
30immunoglobulin mediated immune response (GO:0016064)3.15352029
31regulation of T-helper 2 cell differentiation (GO:0045628)3.05352145
32cellular extravasation (GO:0045123)3.05003958
33response to type I interferon (GO:0034340)3.04106263
34positive regulation of interferon-beta production (GO:0032728)3.03816635
35defense response to protozoan (GO:0042832)3.03079618
36macrophage activation involved in immune response (GO:0002281)3.00916055
37regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00410568
38cellular response to type I interferon (GO:0071357)2.99198524
39type I interferon signaling pathway (GO:0060337)2.99198524
40negative regulation of cytokine production involved in immune response (GO:0002719)2.99168509
41regulation of B cell receptor signaling pathway (GO:0050855)2.98584197
42cellular response to interferon-alpha (GO:0035457)2.98168483
43regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97733613
44peptidyl-glutamic acid carboxylation (GO:0017187)2.96833378
45protein carboxylation (GO:0018214)2.96833378
46positive regulation of Cdc42 GTPase activity (GO:0043089)2.94468254
47negative regulation of viral genome replication (GO:0045071)2.93667633
48T-helper 1 type immune response (GO:0042088)2.92802053
49plasma lipoprotein particle clearance (GO:0034381)2.92777907
50granulocyte activation (GO:0036230)2.92509105
51response to protozoan (GO:0001562)2.92013996
52macrophage activation (GO:0042116)2.91119795
53positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.91047180
54negative regulation of T cell mediated immunity (GO:0002710)2.90452383
55neutrophil activation (GO:0042119)2.87882282
56negative regulation of lymphocyte mediated immunity (GO:0002707)2.87553758
57regulation of gamma-delta T cell activation (GO:0046643)2.85911178
58regulation of gamma-delta T cell differentiation (GO:0045586)2.83823176
59myeloid cell activation involved in immune response (GO:0002275)2.83409276
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83170172
61positive regulation of type 2 immune response (GO:0002830)2.81924751
62myeloid dendritic cell differentiation (GO:0043011)2.81916960
63regulation of T-helper 1 cell differentiation (GO:0045625)2.81913356
64regulation of necroptotic process (GO:0060544)2.80696384
65urea cycle (GO:0000050)2.80321070
66urea metabolic process (GO:0019627)2.80321070
67response to host immune response (GO:0052572)2.79599873
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79599873
69complement activation, alternative pathway (GO:0006957)2.78714975
70positive regulation of B cell differentiation (GO:0045579)2.78230085
71phospholipid efflux (GO:0033700)2.77027734
72positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76671098
73neutrophil activation involved in immune response (GO:0002283)2.74864438
74response to interferon-alpha (GO:0035455)2.72286559
75interferon-gamma secretion (GO:0072643)2.72183925
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71244337
77production of molecular mediator involved in inflammatory response (GO:0002532)2.71026601
78phospholipid homeostasis (GO:0055091)2.70856762
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70699952
80response to interleukin-15 (GO:0070672)2.69932970
81response to peptidoglycan (GO:0032494)2.68888814
82negative regulation of leukocyte mediated immunity (GO:0002704)2.68153638
83regulation of type 2 immune response (GO:0002828)2.67852706
84protein localization to endosome (GO:0036010)2.67353253
85regulation of vitamin D biosynthetic process (GO:0060556)2.66518666
86B cell mediated immunity (GO:0019724)2.65628033
87microglial cell activation (GO:0001774)2.65230030
88cellular response to virus (GO:0098586)2.64322802
89antigen processing and presentation via MHC class Ib (GO:0002475)2.63611071
90T cell migration (GO:0072678)2.62679586
91regulation of leukocyte degranulation (GO:0043300)2.61650800
92negative regulation of type 2 immune response (GO:0002829)2.61533766
93negative regulation of lipid storage (GO:0010888)2.60430897
94regulation of mast cell degranulation (GO:0043304)2.59303060
95negative regulation of toll-like receptor signaling pathway (GO:0034122)2.59223317
96regulation of T cell tolerance induction (GO:0002664)2.59098281
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.58310070
98high-density lipoprotein particle remodeling (GO:0034375)2.58141987
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58113595
100response to host (GO:0075136)2.58113595
101response to host defenses (GO:0052200)2.58113595
102positive regulation of lipid storage (GO:0010884)2.56682731
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56035964
104positive regulation of cellular amide metabolic process (GO:0034250)2.54842873
105myeloid dendritic cell activation (GO:0001773)2.54638807
106B cell receptor signaling pathway (GO:0050853)2.51656777
107regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51062304
108kynurenine metabolic process (GO:0070189)2.50254997
109regulation of cholesterol homeostasis (GO:2000188)2.49704619
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49365595
111plasma lipoprotein particle assembly (GO:0034377)2.49237385
112positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49130464
113cellular response to interferon-gamma (GO:0071346)2.49059180
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49045953
115alpha-linolenic acid metabolic process (GO:0036109)2.48951066
116tryptophan catabolic process (GO:0006569)2.48809019
117indole-containing compound catabolic process (GO:0042436)2.48809019
118indolalkylamine catabolic process (GO:0046218)2.48809019
119nitrogen cycle metabolic process (GO:0071941)2.48179694
120regulation of triglyceride catabolic process (GO:0010896)2.47772167
121regulation of protein activation cascade (GO:2000257)2.47295477
122cysteine metabolic process (GO:0006534)2.47187417
123regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47111216
124positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.46783603
125L-alpha-amino acid transmembrane transport (GO:1902475)2.45667969
126reverse cholesterol transport (GO:0043691)2.45657235
127homocysteine metabolic process (GO:0050667)2.44995580
128negative regulation of sterol transport (GO:0032372)2.44976100
129negative regulation of cholesterol transport (GO:0032375)2.44976100
130negative regulation of interleukin-12 production (GO:0032695)2.44969110
131aromatic amino acid family catabolic process (GO:0009074)2.44855642
132regulation of interferon-beta production (GO:0032648)2.44149379
133tryptophan metabolic process (GO:0006568)2.43132824
134pinocytosis (GO:0006907)2.41215423
135I-kappaB phosphorylation (GO:0007252)2.40735421
136negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.40396654
137negative regulation of fibrinolysis (GO:0051918)2.37908909
138L-phenylalanine metabolic process (GO:0006558)2.37680163
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37680163
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37384554
141response to muramyl dipeptide (GO:0032495)2.37361264
142regulation of superoxide anion generation (GO:0032928)2.36944033
143regulation of complement activation (GO:0030449)2.36026070
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.35565467
145L-phenylalanine catabolic process (GO:0006559)2.35565467
146protein-lipid complex assembly (GO:0065005)2.35158122
147intestinal cholesterol absorption (GO:0030299)2.33714813
148cholesterol efflux (GO:0033344)2.31750800
149acute-phase response (GO:0006953)2.31045883
150lipoprotein metabolic process (GO:0042157)2.30765420
151respiratory burst (GO:0045730)2.29520028
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28992721
153positive regulation of toll-like receptor signaling pathway (GO:0034123)2.28715008
154apoptotic cell clearance (GO:0043277)2.27929818
155detection of molecule of bacterial origin (GO:0032490)2.27868792
156cytokine secretion (GO:0050663)2.27774028
157sulfur amino acid catabolic process (GO:0000098)2.27522427
158regulation of B cell differentiation (GO:0045577)2.27318512
159positive regulation of antigen processing and presentation (GO:0002579)2.27150616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.54755528
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20686937
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.53988653
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.22257741
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.14080128
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05365567
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.01801251
8E2F7_22180533_ChIP-Seq_HELA_Human2.80975488
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72404611
10* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58686316
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57165459
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.56675606
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.51404685
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50989438
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50246746
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43629465
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.42380587
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26926042
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26818316
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20476052
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19638486
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14473896
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08217383
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02202142
25MYC_22102868_ChIP-Seq_BL_Human1.98216169
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98098523
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88748121
28GATA1_22025678_ChIP-Seq_K562_Human1.88086413
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86162546
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.85387199
31* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79200147
32VDR_21846776_ChIP-Seq_THP-1_Human1.74278488
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73246945
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70129368
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69935170
36* MAF_26560356_Chip-Seq_TH1_Human1.64418994
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62352484
38* LXR_22292898_ChIP-Seq_THP-1_Human1.60685671
39SCL_19346495_ChIP-Seq_HPC-7_Human1.60609268
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57469515
41RACK7_27058665_Chip-Seq_MCF-7_Human1.55339776
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.54353226
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53837452
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51587087
45MYB_26560356_Chip-Seq_TH1_Human1.51344923
46MYB_26560356_Chip-Seq_TH2_Human1.49469125
47* SPI1_23547873_ChIP-Seq_NB4_Human1.45835750
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43866788
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.42395799
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.40869085
51TCF7_22412390_ChIP-Seq_EML_Mouse1.40781309
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40066439
53VDR_24763502_ChIP-Seq_THP-1_Human1.37565988
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.35963226
55RUNX_20019798_ChIP-Seq_JUKART_Human1.34458145
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33094703
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32278619
58UTX_26944678_Chip-Seq_JUKART_Human1.31149034
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30693064
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29981010
61* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29823663
62CLOCK_20551151_ChIP-Seq_293T_Human1.28640408
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.28359598
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27414634
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23537271
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21896234
67VDR_24787735_ChIP-Seq_THP-1_Human1.21623644
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20147350
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20059604
70PU_27001747_Chip-Seq_BMDM_Mouse1.18178439
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17129595
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.15730634
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13818189
74SPI1_23127762_ChIP-Seq_K562_Human1.13694397
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10081520
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09555300
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09488647
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09059942
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09047764
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07690251
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07560713
82GATA6_25053715_ChIP-Seq_YYC3_Human1.05062252
83* ATF3_27146783_Chip-Seq_COLON_Human1.04608799
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04063601
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02589905
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01822407
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00723123
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00584298
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00263558
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.99953718
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99139915
92* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98647896
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98276737
94* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98155891
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98001001
96* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97958906
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96694288
98KDM2B_26808549_Chip-Seq_K562_Human0.96691315
99NCOR1_26117541_ChIP-Seq_K562_Human0.96688104
100MAF_26560356_Chip-Seq_TH2_Human0.96635002
101ZNF263_19887448_ChIP-Seq_K562_Human0.96211313
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95642643
103* TFEB_21752829_ChIP-Seq_HELA_Human0.95454728
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95173004
105KDM2B_26808549_Chip-Seq_DND41_Human0.94610286
106* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93263269
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92927744
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90032091
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88904147
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88420387
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87965777
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86952527
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86756161
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86291874
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85545415
116* GATA2_21666600_ChIP-Seq_HMVEC_Human0.85448113
117GATA4_25053715_ChIP-Seq_YYC3_Human0.85351378
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85082970
119* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84656883
120GATA3_27048872_Chip-Seq_THYMUS_Human0.84513696
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82669881
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81743142
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.81293138
124GATA1_19941826_ChIP-Seq_K562_Human0.80615402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.26668139
2MP0002139_abnormal_hepatobiliary_system3.12680790
3MP0005451_abnormal_body_composition2.79752876
4MP0001835_abnormal_antigen_presentation2.75205294
5MP0009840_abnormal_foam_cell2.74129517
6MP0003436_decreased_susceptibility_to2.52521265
7MP0005365_abnormal_bile_salt2.40005817
8MP0005085_abnormal_gallbladder_physiolo2.36301755
9MP0003191_abnormal_cellular_cholesterol2.36129490
10MP0003303_peritoneal_inflammation2.23327897
11MP0001790_abnormal_immune_system2.10946423
12MP0005387_immune_system_phenotype2.10946423
13MP0009785_altered_susceptibility_to2.08043281
14MP0000685_abnormal_immune_system2.04156334
15MP0001800_abnormal_humoral_immune2.00676385
16MP0003300_gastrointestinal_ulcer1.99779941
17MP0005025_abnormal_response_to1.90797510
18MP0002419_abnormal_innate_immunity1.90283495
19MP0006082_CNS_inflammation1.83908267
20MP0003252_abnormal_bile_duct1.83850372
21MP0003724_increased_susceptibility_to1.82706676
22MP0002452_abnormal_antigen_presenting1.82252289
23MP0005000_abnormal_immune_tolerance1.80573534
24MP0008875_abnormal_xenobiotic_pharmacok1.80239031
25MP0005058_abnormal_lysosome_morphology1.79508643
26MP0003705_abnormal_hypodermis_morpholog1.78614099
27MP0008260_abnormal_autophagy1.75793055
28MP0004947_skin_inflammation1.74480736
29MP0003806_abnormal_nucleotide_metabolis1.72679552
30MP0002723_abnormal_immune_serum1.66905015
31MP0005464_abnormal_platelet_physiology1.65897230
32MP0010352_gastrointestinal_tract_polyps1.62257101
33MP0010329_abnormal_lipoprotein_level1.61676017
34MP0002138_abnormal_hepatobiliary_system1.58481578
35MP0002877_abnormal_melanocyte_morpholog1.55037718
36MP0009278_abnormal_bone_marrow1.54893888
37MP0002148_abnormal_hypersensitivity_rea1.54265202
38MP0000609_abnormal_liver_physiology1.53472554
39MP0005083_abnormal_biliary_tract1.51542259
40MP0010155_abnormal_intestine_physiology1.50316538
41MP0001819_abnormal_immune_cell1.48670478
42MP0002420_abnormal_adaptive_immunity1.47248847
43MP0008469_abnormal_protein_level1.43350385
44MP0001845_abnormal_inflammatory_respons1.43252913
45MP0003075_altered_response_to1.42588321
46MP0005076_abnormal_cell_differentiation1.38100385
47MP0003566_abnormal_cell_adhesion1.37068120
48MP0001853_heart_inflammation1.35442254
49MP0005671_abnormal_response_to1.33204640
50MP0002405_respiratory_system_inflammati1.33033349
51MP0003091_abnormal_cell_migration1.32316811
52MP0001666_abnormal_nutrient_absorption1.32018344
53MP0009764_decreased_sensitivity_to1.29796622
54MP0002166_altered_tumor_susceptibility1.29071214
55MP0005397_hematopoietic_system_phenotyp1.27180956
56MP0001545_abnormal_hematopoietic_system1.27180956
57MP0002398_abnormal_bone_marrow1.26618344
58MP0010307_abnormal_tumor_latency1.26325446
59MP0001533_abnormal_skeleton_physiology1.26277513
60MP0000689_abnormal_spleen_morphology1.24514038
61MP0002396_abnormal_hematopoietic_system1.24302682
62MP0003172_abnormal_lysosome_physiology1.23995841
63MP0000716_abnormal_immune_system1.23717949
64MP0004510_myositis1.22952674
65MP0005164_abnormal_response_to1.21409766
66MP0002254_reproductive_system_inflammat1.20386133
67MP0005319_abnormal_enzyme/_coenzyme1.19129035
68MP0003448_altered_tumor_morphology1.17334641
69MP0003183_abnormal_peptide_metabolism1.17249161
70MP0002722_abnormal_immune_system1.13279073
71MP0003453_abnormal_keratinocyte_physiol1.10697696
72MP0002429_abnormal_blood_cell1.09396211
73MP0004883_abnormal_blood_vessel1.08217737
74MP0005023_abnormal_wound_healing1.08204559
75MP0009763_increased_sensitivity_to1.07437406
76MP0004264_abnormal_extraembryonic_tissu1.06606391
77MP0000598_abnormal_liver_morphology1.05476814
78MP0009333_abnormal_splenocyte_physiolog1.04806898
79MP0001873_stomach_inflammation1.04115984
80MP0000858_altered_metastatic_potential1.02756717
81MP0003186_abnormal_redox_activity1.02732031
82MP0002006_tumorigenesis1.01647678
83MP0002332_abnormal_exercise_endurance1.00405614
84MP0003866_abnormal_defecation1.00108099
85MP0001851_eye_inflammation0.97879549
86MP0008004_abnormal_stomach_pH0.97578381
87MP0009643_abnormal_urine_homeostasis0.97005759
88MP0004185_abnormal_adipocyte_glucose0.96706454
89MP0004019_abnormal_vitamin_homeostasis0.96285225
90MP0004381_abnormal_hair_follicle0.95147614
91MP0005332_abnormal_amino_acid0.93971624
92MP0002132_abnormal_respiratory_system0.93921901
93MP0000343_altered_response_to0.92735935
94MP0002118_abnormal_lipid_homeostasis0.92212770
95MP0002796_impaired_skin_barrier0.91373948
96MP0003656_abnormal_erythrocyte_physiolo0.91225114
97MP0004808_abnormal_hematopoietic_stem0.90869436
98MP0000490_abnormal_crypts_of0.86263633
99MP0005390_skeleton_phenotype0.84621940
100MP0002136_abnormal_kidney_physiology0.84378160
101MP0003221_abnormal_cardiomyocyte_apopto0.84335385
102MP0001849_ear_inflammation0.81966646
103MP0010234_abnormal_vibrissa_follicle0.81406475
104MP0003045_fibrosis0.80935159
105MP0000604_amyloidosis0.80649085
106MP0005670_abnormal_white_adipose0.79663668
107MP0003763_abnormal_thymus_physiology0.79403922
108MP0003690_abnormal_glial_cell0.77785216
109MP0001915_intracranial_hemorrhage0.77507286
110MP0001216_abnormal_epidermal_layer0.77446872
111MP0003195_calcinosis0.76990709
112MP0002998_abnormal_bone_remodeling0.76895960
113MP0000465_gastrointestinal_hemorrhage0.76514777
114MP0005310_abnormal_salivary_gland0.75151159
115MP0000371_diluted_coat_color0.75035171
116MP0005666_abnormal_adipose_tissue0.74548920
117MP0000249_abnormal_blood_vessel0.73981299
118MP0001663_abnormal_digestive_system0.71320778
119MP0006054_spinal_hemorrhage0.71173383
120MP0003828_pulmonary_edema0.70721029
121MP0005166_decreased_susceptibility_to0.69687319
122MP0000703_abnormal_thymus_morphology0.69419017
123MP0004858_abnormal_nervous_system0.68997181
124MP0005167_abnormal_blood-brain_barrier0.68996841
125MP0003795_abnormal_bone_structure0.67368781

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)4.20484180
2Retrobulbar optic neuritis (HP:0100654)4.20484180
3Recurrent gram-negative bacterial infections (HP:0005420)4.01985060
4Eczematoid dermatitis (HP:0000976)4.00672196
5Recurrent bacterial skin infections (HP:0005406)3.71050714
6Recurrent abscess formation (HP:0002722)3.70653367
7Autoimmune thrombocytopenia (HP:0001973)3.67720433
8Myocardial infarction (HP:0001658)3.46616236
9Deep venous thrombosis (HP:0002625)3.37225467
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37209598
11Xanthomatosis (HP:0000991)3.29887763
12Intrahepatic cholestasis (HP:0001406)3.26865748
13Systemic lupus erythematosus (HP:0002725)3.22002381
14Joint hemorrhage (HP:0005261)3.21143949
15Increased IgE level (HP:0003212)3.17766911
16Keratoconjunctivitis sicca (HP:0001097)3.13415432
17Abnormality of glycolipid metabolism (HP:0010969)3.06392186
18Abnormality of liposaccharide metabolism (HP:0010968)3.06392186
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.06392186
20Complement deficiency (HP:0004431)3.06335005
21Recurrent viral infections (HP:0004429)3.02562402
22Vacuolated lymphocytes (HP:0001922)3.02164438
23Gastrointestinal infarctions (HP:0005244)3.01068730
24Recurrent fungal infections (HP:0002841)2.97158383
25Abnormality of macrophages (HP:0004311)2.94094342
26Esophageal varix (HP:0002040)2.88999012
27Gingival bleeding (HP:0000225)2.85102812
28Pustule (HP:0200039)2.75834531
29Keratoconjunctivitis (HP:0001096)2.75810710
30Stomatitis (HP:0010280)2.74877379
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72379197
32Chronic obstructive pulmonary disease (HP:0006510)2.70590061
33Obstructive lung disease (HP:0006536)2.70590061
34Abnormality of the common coagulation pathway (HP:0010990)2.70269959
35Periodontitis (HP:0000704)2.62628007
36Spontaneous hematomas (HP:0007420)2.61984346
37Recurrent skin infections (HP:0001581)2.61068558
38Hypobetalipoproteinemia (HP:0003563)2.60951915
39Abnormality of complement system (HP:0005339)2.60937669
40Elevated erythrocyte sedimentation rate (HP:0003565)2.58509512
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57920573
42Hypercholesterolemia (HP:0003124)2.57056185
43Loss of speech (HP:0002371)2.55156455
44Myositis (HP:0100614)2.54578534
45Pulmonary infiltrates (HP:0002113)2.51830598
46Prolonged partial thromboplastin time (HP:0003645)2.50651533
47Mediastinal lymphadenopathy (HP:0100721)2.46629409
48Encephalitis (HP:0002383)2.44672478
49Hyperlipoproteinemia (HP:0010980)2.44346352
50Cellulitis (HP:0100658)2.43342116
51Glomerulonephritis (HP:0000099)2.41144097
52Increased cerebral lipofuscin (HP:0011813)2.40762989
53Colitis (HP:0002583)2.39778637
54Interstitial pulmonary disease (HP:0006530)2.37190032
55Gingivitis (HP:0000230)2.36611305
56Chronic otitis media (HP:0000389)2.36426605
57Abnormality of pyrimidine metabolism (HP:0004353)2.34919759
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.34385436
59Amyloidosis (HP:0011034)2.31224813
60Peritonitis (HP:0002586)2.31124169
61Vasculitis (HP:0002633)2.30258256
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30104028
63Hematochezia (HP:0002573)2.29908713
64Hypolipoproteinemia (HP:0010981)2.29781894
65Hemoptysis (HP:0002105)2.29115815
66Axonal loss (HP:0003447)2.28410195
67Hypoalphalipoproteinemia (HP:0003233)2.28119135
68Epidermoid cyst (HP:0200040)2.26851301
69Abnormality of the nasal mucosa (HP:0000433)2.26433804
70Orchitis (HP:0100796)2.25364988
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23997584
72Gangrene (HP:0100758)2.23219211
73Nasal polyposis (HP:0100582)2.20499209
74Abnormality of iron homeostasis (HP:0011031)2.17246124
75Gastrointestinal stroma tumor (HP:0100723)2.16468794
76Nephritis (HP:0000123)2.16303647
77T lymphocytopenia (HP:0005403)2.14869997
78Epistaxis (HP:0000421)2.14292315
79Chest pain (HP:0100749)2.13930307
80Increased IgM level (HP:0003496)2.13734575
81Increased serum ferritin (HP:0003281)2.13347244
82Inflammation of the large intestine (HP:0002037)2.13014025
83Urticaria (HP:0001025)2.12735363
84Abnormality of the peritoneum (HP:0002585)2.12542848
85Slow saccadic eye movements (HP:0000514)2.11795918
86Urinary glycosaminoglycan excretion (HP:0003541)2.11781281
87Mucopolysacchariduria (HP:0008155)2.11781281
88Hemorrhage of the eye (HP:0011885)2.10058316
89Hypergammaglobulinemia (HP:0010702)2.09523683
90Osteomyelitis (HP:0002754)2.08823787
91Gastrointestinal inflammation (HP:0004386)2.06937831
92Menorrhagia (HP:0000132)2.06878999
93Abnormality of nucleobase metabolism (HP:0010932)2.05604193
94Fat malabsorption (HP:0002630)2.05514760
95Tetraparesis (HP:0002273)2.05245233
96Arterial thrombosis (HP:0004420)2.05092480
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.04957993
98Subacute progressive viral hepatitis (HP:0006572)2.03921945
99Abnormality of transition element cation homeostasis (HP:0011030)2.03385736
100Abnormality of T cell number (HP:0011839)2.03355886
101Dysostosis multiplex (HP:0000943)2.03042515
102Autoimmune hemolytic anemia (HP:0001890)2.02476228
103Hyperammonemia (HP:0001987)2.00347044
104Hydroxyprolinuria (HP:0003080)1.99931736
105Abnormality of proline metabolism (HP:0010907)1.99931736
106Abnormality of polysaccharide metabolism (HP:0011012)1.99500928
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99500928
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99500928
109Viral hepatitis (HP:0006562)1.98944195
110Polycythemia (HP:0001901)1.98508914
111Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97704560
112Hypoglycemic coma (HP:0001325)1.97350153
113Abnormal platelet function (HP:0011869)1.96665308
114Impaired platelet aggregation (HP:0003540)1.96665308
115Skin ulcer (HP:0200042)1.96578642
116Segmental peripheral demyelination/remyelination (HP:0003481)1.94450572
117Thrombophlebitis (HP:0004418)1.94218831
118Prolonged bleeding time (HP:0003010)1.94181665
119Pulmonary embolism (HP:0002204)1.93963214
120Recurrent cutaneous fungal infections (HP:0011370)1.92798148
121Chronic mucocutaneous candidiasis (HP:0002728)1.92798148
122Abnormal platelet volume (HP:0011876)1.92796952
123Mitral stenosis (HP:0001718)1.92439404
124Glomerulopathy (HP:0100820)1.92422009
125Abnormality of the endocardium (HP:0004306)1.91213403
126Abnormality of purine metabolism (HP:0004352)1.90946410
127Emphysema (HP:0002097)1.90614837
128Nausea (HP:0002018)1.90415274
129Episodic fever (HP:0001954)1.89062882
130Osteolytic defects of the hand bones (HP:0009699)1.88187716
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.88187716
132Cheilitis (HP:0100825)1.87906388
133Abnormality of the pleura (HP:0002103)1.87268104
134Polygenic inheritance (HP:0010982)1.86550076
135Meningitis (HP:0001287)1.86183223
136Spastic diplegia (HP:0001264)1.85472129
137Recurrent bronchitis (HP:0002837)1.84728339
138Fatigue (HP:0012378)1.84582957
139Anorexia (HP:0002039)1.83701124
140Flat acetabular roof (HP:0003180)1.83581612
141Abnormality of the pericardium (HP:0001697)1.83089626
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.82909166
143Disinhibition (HP:0000734)1.82705515
144Granulocytopenia (HP:0001913)1.81912981
145Abnormality of the intrinsic pathway (HP:0010989)1.81655941
146Purpura (HP:0000979)1.80802052
147Aseptic necrosis (HP:0010885)1.80471993
148IgM deficiency (HP:0002850)1.80234214
149Premature loss of primary teeth (HP:0006323)1.77796160
150Hepatosplenomegaly (HP:0001433)1.77726889
151Thin bony cortex (HP:0002753)1.75253119
152Leukocytosis (HP:0001974)1.73159485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.68225726
2PRPF4B3.23826281
3MAP4K13.07721554
4TYK22.98636657
5CDK122.59581739
6TBK12.41016108
7MAP3K142.36644439
8FGFR42.32794875
9MAP3K102.20359147
10STK102.17831705
11JAK32.08556456
12SMG12.07677199
13TRIB31.98048353
14IKBKE1.91441659
15PKN21.90046677
16TGFBR21.81903738
17BLK1.81354986
18IRAK31.73328753
19KIT1.69807777
20JAK11.69313278
21TAOK31.69111248
22FLT31.68582550
23TAOK21.67649989
24IKBKB1.61674982
25ZAP701.54078876
26TAOK11.53289547
27CSK1.53159723
28IRAK41.46804155
29RIPK11.46566395
30SIK11.43972165
31PTK61.41901377
32EPHB11.39513371
33GRK61.34808552
34MAP2K31.34701950
35ICK1.30676150
36EEF2K1.27991048
37MAP3K11.27103762
38FGFR31.26066244
39PIM11.24074553
40SIK31.22073263
41KSR21.21286127
42LRRK21.21005096
43RPS6KA41.19566946
44CSF1R1.19299075
45CDK61.13533070
46CHUK1.13010804
47BTK1.12224095
48BMPR21.11938848
49EPHA21.10262965
50KDR1.08885398
51CDC42BPA1.08231107
52NME21.07150835
53MAP3K131.05698261
54IRAK21.03423864
55CAMK1D1.02462170
56IRAK11.01949600
57MAP3K31.00663946
58JAK21.00646034
59HCK0.99529890
60STK30.99417160
61NEK90.94289763
62CDK40.93082215
63ITK0.91633214
64STK40.91458978
65FES0.90393506
66MST1R0.88941310
67SYK0.88705471
68TEC0.83983553
69MAPK110.82652205
70MST40.82498376
71BCKDK0.82478276
72MAP3K60.81685481
73TNK20.81585039
74LCK0.81561844
75PIM20.80662360
76EPHA30.79987249
77PDPK10.79668749
78MARK30.78788103
79HIPK20.76532796
80PRKD20.76517985
81MAP3K80.75598413
82RIPK40.75124239
83TXK0.74846020
84MATK0.72342251
85YES10.72087607
86TTN0.71429390
87BMX0.70408060
88MARK20.70319616
89PDK10.68636532
90RPS6KB20.67549719
91MAP3K20.66743825
92MOS0.66110773
93MTOR0.65447542
94NEK20.65317690
95GRK70.64488180
96LYN0.64142566
97EGFR0.63723699
98MAP3K50.61389745
99DDR20.61217511
100PAK40.60608195
101CDK90.60169037
102MAP3K110.58267135
103TESK20.56654714
104MELK0.54182727
105GSK3A0.53171343
106BRD40.52667283
107ABL10.50213648
108LATS10.49433109
109MET0.49034604
110TGFBR10.48810418
111MAP2K20.48413851
112FGR0.47433740
113PRKG20.46656887
114NLK0.46156868
115ALK0.45262089
116SCYL20.44629040
117CLK10.43776558
118SIK20.43387542
119RET0.42666013
120RPS6KL10.41931386
121RPS6KC10.41931386
122SGK30.41444760
123CAMK1G0.40878407
124PDGFRB0.39641788
125CDK70.39145649
126MAPK70.38619359
127TRPM70.38468930
128FRK0.38220017
129PBK0.35748512
130ABL20.35369879
131PRKAA20.34700354
132PTK20.34314676
133MAPKAPK20.33992229
134PDGFRA0.31372288

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.97320236
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.46373476
3Caffeine metabolism_Homo sapiens_hsa002322.41829713
4Complement and coagulation cascades_Homo sapiens_hsa046102.31974129
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29688173
6Leishmaniasis_Homo sapiens_hsa051401.97402184
7Arginine biosynthesis_Homo sapiens_hsa002201.94518963
8Nitrogen metabolism_Homo sapiens_hsa009101.89441850
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88183414
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78875899
11* NF-kappa B signaling pathway_Homo sapiens_hsa040641.76625371
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74429459
13Autoimmune thyroid disease_Homo sapiens_hsa053201.63059759
14Osteoclast differentiation_Homo sapiens_hsa043801.55731667
15Tryptophan metabolism_Homo sapiens_hsa003801.55621215
16Measles_Homo sapiens_hsa051621.52013346
17* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45283027
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44691945
19B cell receptor signaling pathway_Homo sapiens_hsa046621.43280870
20PPAR signaling pathway_Homo sapiens_hsa033201.40586871
21Fatty acid degradation_Homo sapiens_hsa000711.40222650
22Legionellosis_Homo sapiens_hsa051341.37634671
23Primary immunodeficiency_Homo sapiens_hsa053401.30840124
24One carbon pool by folate_Homo sapiens_hsa006701.29188374
25Non-small cell lung cancer_Homo sapiens_hsa052231.28763919
26Selenocompound metabolism_Homo sapiens_hsa004501.28645857
27Antigen processing and presentation_Homo sapiens_hsa046121.28020214
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27353542
29Herpes simplex infection_Homo sapiens_hsa051681.26283887
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.23823040
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23177643
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.22872599
33* Influenza A_Homo sapiens_hsa051641.21482837
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20684966
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.18919905
36Type I diabetes mellitus_Homo sapiens_hsa049401.17151784
37Histidine metabolism_Homo sapiens_hsa003401.16500022
38Bladder cancer_Homo sapiens_hsa052191.15377977
39Salmonella infection_Homo sapiens_hsa051321.14997256
40Pertussis_Homo sapiens_hsa051331.14296422
41Lysine degradation_Homo sapiens_hsa003101.14280360
42VEGF signaling pathway_Homo sapiens_hsa043701.13520019
43Toxoplasmosis_Homo sapiens_hsa051451.11730740
44Prolactin signaling pathway_Homo sapiens_hsa049171.11636673
45TNF signaling pathway_Homo sapiens_hsa046681.11460752
46Asthma_Homo sapiens_hsa053101.10008667
47Fat digestion and absorption_Homo sapiens_hsa049751.09590862
48ABC transporters_Homo sapiens_hsa020101.09176289
49Tuberculosis_Homo sapiens_hsa051521.06849015
50Folate biosynthesis_Homo sapiens_hsa007901.03698102
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03526050
52Peroxisome_Homo sapiens_hsa041461.03459789
53Malaria_Homo sapiens_hsa051441.03245299
54Apoptosis_Homo sapiens_hsa042101.02657773
55Hepatitis C_Homo sapiens_hsa051600.99448510
56Chemical carcinogenesis_Homo sapiens_hsa052040.99400600
57Renal cell carcinoma_Homo sapiens_hsa052110.99362952
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98149018
59Lysosome_Homo sapiens_hsa041420.98125743
60Rheumatoid arthritis_Homo sapiens_hsa053230.97115626
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96905537
62Phagosome_Homo sapiens_hsa041450.96631758
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96212434
64Starch and sucrose metabolism_Homo sapiens_hsa005000.94837193
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92062328
66Hematopoietic cell lineage_Homo sapiens_hsa046400.91507724
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.90311442
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89969820
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.87766599
70Other glycan degradation_Homo sapiens_hsa005110.87387814
71beta-Alanine metabolism_Homo sapiens_hsa004100.85941384
72Vitamin digestion and absorption_Homo sapiens_hsa049770.85070480
73Acute myeloid leukemia_Homo sapiens_hsa052210.84439307
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82786944
75Epstein-Barr virus infection_Homo sapiens_hsa051690.82478751
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82400912
77Hepatitis B_Homo sapiens_hsa051610.82136020
78Endometrial cancer_Homo sapiens_hsa052130.80006820
79Prion diseases_Homo sapiens_hsa050200.79335366
80Notch signaling pathway_Homo sapiens_hsa043300.77464261
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.76585294
82Chronic myeloid leukemia_Homo sapiens_hsa052200.74182366
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74005650
84Insulin resistance_Homo sapiens_hsa049310.73370195
85Small cell lung cancer_Homo sapiens_hsa052220.73296598
86Retinol metabolism_Homo sapiens_hsa008300.73218534
87Bile secretion_Homo sapiens_hsa049760.72833431
88HTLV-I infection_Homo sapiens_hsa051660.71101939
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.70805273
90Platelet activation_Homo sapiens_hsa046110.69968193
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.69880953
92Prostate cancer_Homo sapiens_hsa052150.68918939
93Thyroid cancer_Homo sapiens_hsa052160.68901948
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.68363905
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68146748
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67898177
97Graft-versus-host disease_Homo sapiens_hsa053320.66793291
98mTOR signaling pathway_Homo sapiens_hsa041500.66739863
99Pentose phosphate pathway_Homo sapiens_hsa000300.66375601
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.65467656
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65388079
102Phenylalanine metabolism_Homo sapiens_hsa003600.64800490
103Fatty acid metabolism_Homo sapiens_hsa012120.64545371
104Shigellosis_Homo sapiens_hsa051310.64533186
105HIF-1 signaling pathway_Homo sapiens_hsa040660.64155121
106Endocytosis_Homo sapiens_hsa041440.63352900
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63315325
108Sulfur relay system_Homo sapiens_hsa041220.63154504
109Allograft rejection_Homo sapiens_hsa053300.61280245
110FoxO signaling pathway_Homo sapiens_hsa040680.61042141
111African trypanosomiasis_Homo sapiens_hsa051430.59447620
112Galactose metabolism_Homo sapiens_hsa000520.59175323
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58725032
114ErbB signaling pathway_Homo sapiens_hsa040120.57957588
115Renin-angiotensin system_Homo sapiens_hsa046140.57112900
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55842408
117Proteoglycans in cancer_Homo sapiens_hsa052050.54726816
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.53335698
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53332230
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.53068495
121Insulin signaling pathway_Homo sapiens_hsa049100.52767692
122GnRH signaling pathway_Homo sapiens_hsa049120.52376223
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51978469
124Glioma_Homo sapiens_hsa052140.51539356
125Fructose and mannose metabolism_Homo sapiens_hsa000510.51151896
126Pancreatic cancer_Homo sapiens_hsa052120.50675059
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50487367
128T cell receptor signaling pathway_Homo sapiens_hsa046600.50001917
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49858180
130Viral carcinogenesis_Homo sapiens_hsa052030.49807390
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49692406
132Viral myocarditis_Homo sapiens_hsa054160.48530260
133Chemokine signaling pathway_Homo sapiens_hsa040620.48254352
134Carbon metabolism_Homo sapiens_hsa012000.47939454
135Type II diabetes mellitus_Homo sapiens_hsa049300.47788989
136Choline metabolism in cancer_Homo sapiens_hsa052310.47276119
137Amoebiasis_Homo sapiens_hsa051460.46860453
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46390956
139Biosynthesis of amino acids_Homo sapiens_hsa012300.45606493
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41064590
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40729325
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38787211
143Colorectal cancer_Homo sapiens_hsa052100.38287962
144MicroRNAs in cancer_Homo sapiens_hsa052060.38216839

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