TRIM21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.74379474
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.74379474
3antigen processing and presentation of endogenous antigen (GO:0019883)6.23169533
4positive regulation of gamma-delta T cell activation (GO:0046645)5.67246023
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.38598327
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.38598327
7modulation by symbiont of host immune response (GO:0052553)5.38598327
8positive regulation by symbiont of host defense response (GO:0052509)5.38598327
9modulation by symbiont of host defense response (GO:0052031)5.38598327
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.38598327
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95594663
12positive regulation of interferon-alpha production (GO:0032727)4.91452118
13response to type I interferon (GO:0034340)4.69833309
14regulation of interferon-alpha production (GO:0032647)4.68765610
15cellular response to type I interferon (GO:0071357)4.64446877
16type I interferon signaling pathway (GO:0060337)4.64446877
17regulation of interferon-beta biosynthetic process (GO:0045357)4.34212124
18regulation of gamma-delta T cell activation (GO:0046643)4.18116742
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.15111993
20regulation of gamma-delta T cell differentiation (GO:0045586)4.12044227
21detection of other organism (GO:0098543)3.95891546
22negative regulation of T cell mediated immunity (GO:0002710)3.94638703
23response to interferon-alpha (GO:0035455)3.84597680
24detection of bacterium (GO:0016045)3.80841723
25macrophage activation involved in immune response (GO:0002281)3.80694290
26response to host immune response (GO:0052572)3.80209270
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.80209270
28T cell migration (GO:0072678)3.79464207
29regulation of type I interferon-mediated signaling pathway (GO:0060338)3.71195181
30response to interleukin-15 (GO:0070672)3.68690119
31positive regulation of interferon-beta production (GO:0032728)3.60587504
32negative regulation of lymphocyte mediated immunity (GO:0002707)3.58402289
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.57730088
34lymphocyte chemotaxis (GO:0048247)3.56998735
35cellular response to interleukin-15 (GO:0071350)3.56082232
36response to host (GO:0075136)3.55596366
37response to host defenses (GO:0052200)3.55596366
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55596366
39immunoglobulin mediated immune response (GO:0016064)3.53620360
40negative regulation of cytokine production involved in immune response (GO:0002719)3.53393030
41positive regulation of type 2 immune response (GO:0002830)3.53122851
42response to peptidoglycan (GO:0032494)3.50351142
43regulation of B cell receptor signaling pathway (GO:0050855)3.50110754
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49049406
45negative regulation of cell killing (GO:0031342)3.49049406
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48877577
47regulation of T cell mediated cytotoxicity (GO:0001914)3.48527853
48JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.44364002
49interferon-gamma-mediated signaling pathway (GO:0060333)3.42246119
50cytidine metabolic process (GO:0046087)3.41169405
51cytidine catabolic process (GO:0006216)3.41169405
52cytidine deamination (GO:0009972)3.41169405
53detection of external biotic stimulus (GO:0098581)3.38181597
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38137708
55negative regulation of leukocyte mediated immunity (GO:0002704)3.34161365
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31260864
57positive thymic T cell selection (GO:0045059)3.29468630
58positive regulation of antigen processing and presentation (GO:0002579)3.28851733
59neutrophil activation (GO:0042119)3.28417012
60negative T cell selection (GO:0043383)3.26792739
61detection of molecule of bacterial origin (GO:0032490)3.26583250
62regulation of regulatory T cell differentiation (GO:0045589)3.23336635
63cellular response to interferon-beta (GO:0035458)3.20771568
64negative thymic T cell selection (GO:0045060)3.17543014
65cellular response to virus (GO:0098586)3.17105593
66NIK/NF-kappaB signaling (GO:0038061)3.15696580
67cellular extravasation (GO:0045123)3.13204092
68cellular response to interferon-alpha (GO:0035457)3.11619586
69defense response to protozoan (GO:0042832)3.11320921
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.10840337
71I-kappaB phosphorylation (GO:0007252)3.10734016
72positive regulation of natural killer cell differentiation (GO:0032825)3.10505202
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10206545
74positive regulation of B cell differentiation (GO:0045579)3.10091398
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09089598
76neutrophil activation involved in immune response (GO:0002283)3.06351118
77positive regulation of humoral immune response (GO:0002922)3.06276661
78regulation of T-helper 1 cell differentiation (GO:0045625)3.06012637
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05675506
80response to muramyl dipeptide (GO:0032495)3.03530778
81production of molecular mediator involved in inflammatory response (GO:0002532)3.02549134
82negative regulation of viral genome replication (GO:0045071)3.02532886
83myeloid dendritic cell differentiation (GO:0043011)3.01388838
84regulation of tolerance induction (GO:0002643)3.00537001
85regulation of response to interferon-gamma (GO:0060330)2.99716839
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99045109
87regulation of natural killer cell mediated immunity (GO:0002715)2.99045109
88natural killer cell mediated cytotoxicity (GO:0042267)2.98313097
89natural killer cell mediated immunity (GO:0002228)2.98313097
90regulation of type 2 immune response (GO:0002828)2.96828615
91leukocyte aggregation (GO:0070486)2.96751459
92regulation of leukocyte mediated cytotoxicity (GO:0001910)2.96526188
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94546266
94detection of biotic stimulus (GO:0009595)2.93836402
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93623142
96response to protozoan (GO:0001562)2.93283976
97respiratory burst (GO:0045730)2.93060887
98negative regulation of interleukin-12 production (GO:0032695)2.92574816
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92451643
100cellular response to exogenous dsRNA (GO:0071360)2.89637547
101positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.88672723
102myeloid cell activation involved in immune response (GO:0002275)2.88548075
103regulation of RIG-I signaling pathway (GO:0039535)2.86336351
104germinal center formation (GO:0002467)2.85073512
105negative regulation of production of molecular mediator of immune response (GO:0002701)2.84971130
106regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.84067149
107antigen processing and presentation via MHC class Ib (GO:0002475)2.83820646
108positive regulation of lymphocyte migration (GO:2000403)2.83481705
109regulation of alpha-beta T cell proliferation (GO:0046640)2.81818882
110regulation of interferon-beta production (GO:0032648)2.80857518
111cellular response to interferon-gamma (GO:0071346)2.78935291
112interferon-gamma production (GO:0032609)2.78622032
113microglial cell activation (GO:0001774)2.78412559
114regulation of B cell differentiation (GO:0045577)2.78309340
115regulation of antigen processing and presentation (GO:0002577)2.77959300
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77166202
117natural killer cell differentiation (GO:0001779)2.74986583
118response to interferon-beta (GO:0035456)2.74171243
119B cell receptor signaling pathway (GO:0050853)2.73904512
120T cell selection (GO:0045058)2.72227333
121regulation of T cell tolerance induction (GO:0002664)2.72194999
122positive regulation of T cell cytokine production (GO:0002726)2.71998556
123pinocytosis (GO:0006907)2.70795078
124B cell mediated immunity (GO:0019724)2.69932547
125positive T cell selection (GO:0043368)2.69412414
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69166908
127defense response to virus (GO:0051607)2.68347804
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.68256960
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66770841
130leukocyte cell-cell adhesion (GO:0007159)2.66418024
131thymic T cell selection (GO:0045061)2.64792711
132T-helper 1 type immune response (GO:0042088)2.63405055
133tolerance induction (GO:0002507)2.61940373
134positive regulation of cytokine biosynthetic process (GO:0042108)2.61591201
135myeloid dendritic cell activation (GO:0001773)2.60911049
136granulocyte activation (GO:0036230)2.58292856
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56719456
138positive regulation of chemokine biosynthetic process (GO:0045080)2.55870858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.41129117
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.15906193
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.00057768
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.93051198
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.22708673
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88968222
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.51202856
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.22194217
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13238740
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10685203
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02188557
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93879400
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.93520898
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85783649
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62984405
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49608636
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49149360
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.39704486
19RUNX_20019798_ChIP-Seq_JUKART_Human2.24701989
20MYB_26560356_Chip-Seq_TH2_Human2.19865501
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17137330
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17005837
23MAF_26560356_Chip-Seq_TH1_Human2.16950966
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15968794
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14902243
26MYC_22102868_ChIP-Seq_BL_Human2.04379031
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01527964
28GATA1_22025678_ChIP-Seq_K562_Human2.00736385
29MYB_26560356_Chip-Seq_TH1_Human1.94837612
30VDR_21846776_ChIP-Seq_THP-1_Human1.88358973
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88154512
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87006358
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85468307
34SCL_19346495_ChIP-Seq_HPC-7_Human1.79295723
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77748560
36SPI1_23547873_ChIP-Seq_NB4_Human1.76722683
37UTX_26944678_Chip-Seq_JUKART_Human1.74735390
38E2F7_22180533_ChIP-Seq_HELA_Human1.72238532
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71229969
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.66102490
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.64347509
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63506415
43VDR_24763502_ChIP-Seq_THP-1_Human1.58695382
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58390749
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56997602
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55089896
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51488982
48TCF7_22412390_ChIP-Seq_EML_Mouse1.51463249
49SPI1_23127762_ChIP-Seq_K562_Human1.51202759
50PU_27001747_Chip-Seq_BMDM_Mouse1.49617656
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47992225
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.47057051
53GATA3_27048872_Chip-Seq_THYMUS_Human1.45073276
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42478267
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40139680
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32046725
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29580563
58MAF_26560356_Chip-Seq_TH2_Human1.26556621
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25086921
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.23225051
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22991831
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18712339
63KDM2B_26808549_Chip-Seq_DND41_Human1.18598489
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18449018
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18220744
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17945603
67GATA3_26560356_Chip-Seq_TH2_Human1.15348548
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12866282
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10980365
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.09368015
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09140009
72* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08172333
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05097152
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03761863
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00579042
76BCL6_27268052_Chip-Seq_Bcells_Human1.00553670
77VDR_24787735_ChIP-Seq_THP-1_Human0.99933889
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99889907
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99877322
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97470505
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97353073
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.96375706
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95505321
84LXR_22292898_ChIP-Seq_THP-1_Human0.94774569
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94512928
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92537776
87* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91637317
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.91515745
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91321264
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90547515
91BCOR_27268052_Chip-Seq_Bcells_Human0.89737664
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86923389
93CLOCK_20551151_ChIP-Seq_293T_Human0.86137624
94EGR1_19032775_ChIP-ChIP_M12_Human0.85660326
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85253460
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.84938437
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84594921
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84156086
99GATA1_19941826_ChIP-Seq_K562_Human0.82782775
100NCOR1_26117541_ChIP-Seq_K562_Human0.81245974
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81090699
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81020672
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80996284
104GATA2_19941826_ChIP-Seq_K562_Human0.80408593
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80253980
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.79496465
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79147977
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79079414
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.79043691
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.78927447
111TFEB_21752829_ChIP-Seq_HELA_Human0.76272942
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.75273125
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74702288
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73319227
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72462026
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72285670
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72023652
118FOXM1_23109430_ChIP-Seq_U2OS_Human0.71576002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93895513
2MP0009785_altered_susceptibility_to3.14291482
3MP0003436_decreased_susceptibility_to2.99987580
4MP0000685_abnormal_immune_system2.99745497
5MP0003303_peritoneal_inflammation2.97833943
6MP0001790_abnormal_immune_system2.94799323
7MP0005387_immune_system_phenotype2.94799323
8MP0001800_abnormal_humoral_immune2.77053650
9MP0003724_increased_susceptibility_to2.69840572
10MP0006082_CNS_inflammation2.67756145
11* MP0005000_abnormal_immune_tolerance2.67626826
12MP0005671_abnormal_response_to2.65105448
13MP0005025_abnormal_response_to2.62988331
14MP0003300_gastrointestinal_ulcer2.56687907
15MP0002452_abnormal_antigen_presenting2.50703968
16MP0002419_abnormal_innate_immunity2.47381215
17* MP0002723_abnormal_immune_serum2.41052207
18MP0002148_abnormal_hypersensitivity_rea2.32518579
19* MP0001819_abnormal_immune_cell2.19718806
20* MP0002420_abnormal_adaptive_immunity2.18535507
21MP0002166_altered_tumor_susceptibility2.06819983
22MP0005058_abnormal_lysosome_morphology2.06704320
23* MP0004947_skin_inflammation2.05662241
24MP0003763_abnormal_thymus_physiology2.01858006
25MP0004510_myositis1.98945491
26MP0005464_abnormal_platelet_physiology1.94861207
27MP0010155_abnormal_intestine_physiology1.93591321
28* MP0002398_abnormal_bone_marrow1.83739447
29MP0001853_heart_inflammation1.82484541
30MP0005451_abnormal_body_composition1.81317860
31* MP0000716_abnormal_immune_system1.78698553
32MP0002006_tumorigenesis1.76855155
33* MP0001845_abnormal_inflammatory_respons1.76084828
34MP0002405_respiratory_system_inflammati1.74903511
35MP0001533_abnormal_skeleton_physiology1.72387464
36MP0009840_abnormal_foam_cell1.65793378
37MP0009278_abnormal_bone_marrow1.63583202
38* MP0008469_abnormal_protein_level1.60967753
39* MP0000689_abnormal_spleen_morphology1.57794734
40MP0003172_abnormal_lysosome_physiology1.57605101
41MP0003191_abnormal_cellular_cholesterol1.48715466
42* MP0002722_abnormal_immune_system1.48687683
43MP0009333_abnormal_splenocyte_physiolog1.48612215
44MP0008260_abnormal_autophagy1.47170636
45* MP0002429_abnormal_blood_cell1.46505830
46MP0009764_decreased_sensitivity_to1.44908842
47MP0003448_altered_tumor_morphology1.39650076
48MP0001873_stomach_inflammation1.36559375
49MP0005360_urolithiasis1.32985957
50MP0002139_abnormal_hepatobiliary_system1.31396409
51MP0001545_abnormal_hematopoietic_system1.29762241
52MP0005397_hematopoietic_system_phenotyp1.29762241
53MP0010307_abnormal_tumor_latency1.28485156
54MP0002396_abnormal_hematopoietic_system1.27486299
55MP0004808_abnormal_hematopoietic_stem1.25255678
56MP0003806_abnormal_nucleotide_metabolis1.24515342
57MP0010352_gastrointestinal_tract_polyps1.24347833
58MP0000569_abnormal_digit_pigmentation1.23621762
59MP0000703_abnormal_thymus_morphology1.18411000
60MP0003705_abnormal_hypodermis_morpholog1.18071663
61MP0002138_abnormal_hepatobiliary_system1.15459788
62MP0002933_joint_inflammation1.14859680
63MP0000343_altered_response_to1.14764356
64MP0002132_abnormal_respiratory_system1.13965923
65MP0002998_abnormal_bone_remodeling1.13849426
66MP0009763_increased_sensitivity_to1.12913194
67MP0000609_abnormal_liver_physiology1.10496777
68MP0000858_altered_metastatic_potential1.10223931
69MP0000604_amyloidosis1.09274108
70MP0000465_gastrointestinal_hemorrhage1.07754821
71MP0005310_abnormal_salivary_gland1.06419487
72MP0005023_abnormal_wound_healing1.06389073
73MP0003566_abnormal_cell_adhesion1.04128232
74MP0003075_altered_response_to1.02125334
75MP0003453_abnormal_keratinocyte_physiol1.00366092
76MP0004883_abnormal_blood_vessel1.00115393
77MP0005083_abnormal_biliary_tract0.97305886
78MP0002277_abnormal_respiratory_mucosa0.96045641
79MP0005076_abnormal_cell_differentiation0.95823556
80MP0003252_abnormal_bile_duct0.93387861
81MP0005365_abnormal_bile_salt0.92901553
82MP0003866_abnormal_defecation0.89985481
83MP0008004_abnormal_stomach_pH0.89350891
84MP0003091_abnormal_cell_migration0.89250747
85MP0005166_decreased_susceptibility_to0.89119929
86MP0001851_eye_inflammation0.88206870
87MP0003045_fibrosis0.86944334
88MP0006054_spinal_hemorrhage0.85571012
89MP0000490_abnormal_crypts_of0.82296655
90MP0001663_abnormal_digestive_system0.78267292
91MP0003690_abnormal_glial_cell0.77884127
92MP0000249_abnormal_blood_vessel0.76442716
93MP0000598_abnormal_liver_morphology0.74248800
94MP0003828_pulmonary_edema0.73593748
95MP0003183_abnormal_peptide_metabolism0.73368346
96MP0010329_abnormal_lipoprotein_level0.72837429
97MP0005319_abnormal_enzyme/_coenzyme0.72073890
98MP0002332_abnormal_exercise_endurance0.71430422
99MP0009765_abnormal_xenobiotic_induced0.70866983
100MP0002254_reproductive_system_inflammat0.70387095
101* MP0002136_abnormal_kidney_physiology0.70085381
102MP0004381_abnormal_hair_follicle0.69977099
103MP0005390_skeleton_phenotype0.69850727
104MP0005164_abnormal_response_to0.69526344
105MP0003795_abnormal_bone_structure0.68694973
106MP0004185_abnormal_adipocyte_glucose0.68211093
107MP0002019_abnormal_tumor_incidence0.67567865
108MP0005085_abnormal_gallbladder_physiolo0.67550627
109MP0003656_abnormal_erythrocyte_physiolo0.66146256
110MP0000371_diluted_coat_color0.65823098
111MP0004130_abnormal_muscle_cell0.65528155
112MP0005174_abnormal_tail_pigmentation0.65339761
113MP0005167_abnormal_blood-brain_barrier0.61331491
114MP0005165_increased_susceptibility_to0.60364526
115MP0002877_abnormal_melanocyte_morpholog0.59531539
116MP0001542_abnormal_bone_strength0.59319219
117MP0005075_abnormal_melanosome_morpholog0.58569019
118MP0008874_decreased_physiological_sensi0.56399652

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.95656977
2Recurrent abscess formation (HP:0002722)4.51638360
3Elevated erythrocyte sedimentation rate (HP:0003565)4.40203498
4Chronic otitis media (HP:0000389)4.35864023
5Recurrent viral infections (HP:0004429)4.29390031
6Recurrent bacterial skin infections (HP:0005406)4.22469185
7Recurrent gram-negative bacterial infections (HP:0005420)3.96445251
8Autoimmune thrombocytopenia (HP:0001973)3.95871041
9Myositis (HP:0100614)3.91885588
10Recurrent fungal infections (HP:0002841)3.87942982
11Encephalitis (HP:0002383)3.87163337
12Nasal polyposis (HP:0100582)3.67140123
13Mediastinal lymphadenopathy (HP:0100721)3.60062383
14Recurrent bronchitis (HP:0002837)3.58415130
15Orchitis (HP:0100796)3.53567203
16T lymphocytopenia (HP:0005403)3.49457623
17Abnormality of T cell number (HP:0011839)3.46129370
18Systemic lupus erythematosus (HP:0002725)3.44876839
19Vasculitis (HP:0002633)3.42965637
20Abnormality of the nasal mucosa (HP:0000433)3.40534445
21Abnormality of macrophages (HP:0004311)3.36765726
22Recurrent skin infections (HP:0001581)3.21307984
23Optic neuritis (HP:0100653)3.17543479
24Retrobulbar optic neuritis (HP:0100654)3.17543479
25Abnormality of liposaccharide metabolism (HP:0010968)3.12319178
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.12319178
27Abnormality of glycolipid metabolism (HP:0010969)3.12319178
28Stomatitis (HP:0010280)3.05170071
29Pustule (HP:0200039)3.02471286
30Gangrene (HP:0100758)2.98712514
31Myocardial infarction (HP:0001658)2.94258019
32Recurrent cutaneous fungal infections (HP:0011370)2.93901334
33Chronic mucocutaneous candidiasis (HP:0002728)2.93901334
34Interstitial pulmonary disease (HP:0006530)2.92326915
35Gingival bleeding (HP:0000225)2.87395556
36Vacuolated lymphocytes (HP:0001922)2.85257930
37Cellulitis (HP:0100658)2.82911818
38Abnormality of T cells (HP:0002843)2.81611602
39Hematochezia (HP:0002573)2.80184768
40Basal ganglia calcification (HP:0002135)2.76149502
41Spontaneous hematomas (HP:0007420)2.74625015
42Arterial thrombosis (HP:0004420)2.73952537
43Periodontitis (HP:0000704)2.73705809
44Gingivitis (HP:0000230)2.71975079
45Increased cerebral lipofuscin (HP:0011813)2.71484009
46Pulmonary infiltrates (HP:0002113)2.69922353
47Meningitis (HP:0001287)2.69782173
48Colitis (HP:0002583)2.68768175
49Abnormality of the pleura (HP:0002103)2.59176494
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.57938513
51Inflammation of the large intestine (HP:0002037)2.56619332
52Eosinophilia (HP:0001880)2.52557936
53Leukocytosis (HP:0001974)2.50678922
54Gastrointestinal inflammation (HP:0004386)2.46605161
55IgG deficiency (HP:0004315)2.44510515
56Chronic obstructive pulmonary disease (HP:0006510)2.44434197
57Obstructive lung disease (HP:0006536)2.44434197
58Hemoptysis (HP:0002105)2.42336506
59Gastrointestinal infarctions (HP:0005244)2.42115061
60Polyneuropathy (HP:0001271)2.36762857
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.36701870
62Lymphopenia (HP:0001888)2.35021923
63Abnormality of the pericardium (HP:0001697)2.34425272
64Keratitis (HP:0000491)2.32753888
65Glomerulopathy (HP:0100820)2.32209445
66IgM deficiency (HP:0002850)2.32086946
67Increased IgE level (HP:0003212)2.31597408
68Emphysema (HP:0002097)2.30855076
69Chronic sinusitis (HP:0011109)2.30373477
70Joint swelling (HP:0001386)2.30229595
71Autoimmune hemolytic anemia (HP:0001890)2.30218695
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.28226163
73Hypergammaglobulinemia (HP:0010702)2.27752263
74Panhypogammaglobulinemia (HP:0003139)2.26954499
75Osteomyelitis (HP:0002754)2.26827258
76Abnormality of T cell physiology (HP:0011840)2.26771206
77Joint hemorrhage (HP:0005261)2.26474860
78Agammaglobulinemia (HP:0004432)2.24990270
79Hepatosplenomegaly (HP:0001433)2.24721256
80Keratoconjunctivitis sicca (HP:0001097)2.24316951
81Abnormality of the endocardium (HP:0004306)2.23501366
82Tetraparesis (HP:0002273)2.22568368
83Increased serum ferritin (HP:0003281)2.22412809
84Gastrointestinal stroma tumor (HP:0100723)2.21628412
85Epistaxis (HP:0000421)2.21577072
86Purpura (HP:0000979)2.20457460
87Chronic diarrhea (HP:0002028)2.19042439
88Episodic fever (HP:0001954)2.18298110
89Acne (HP:0001061)2.17895609
90Increased IgM level (HP:0003496)2.17110110
91Pulmonary embolism (HP:0002204)2.14717639
92Granulocytopenia (HP:0001913)2.13939973
93Glomerulonephritis (HP:0000099)2.13611728
94Complement deficiency (HP:0004431)2.13430891
95Axonal loss (HP:0003447)2.11887296
96Thrombophlebitis (HP:0004418)2.11324554
97IgA deficiency (HP:0002720)2.11104955
98Esophageal varix (HP:0002040)2.10835455
99Nephritis (HP:0000123)2.10770426
100Dysostosis multiplex (HP:0000943)2.09661304
101Hypochromic anemia (HP:0001931)2.08755488
102Amyloidosis (HP:0011034)2.08543247
103Premature loss of primary teeth (HP:0006323)2.07904031
104Urticaria (HP:0001025)2.07874815
105Chest pain (HP:0100749)2.07377087
106Hypochromic microcytic anemia (HP:0004840)2.07151756
107Vertigo (HP:0002321)2.06230768
108Severe combined immunodeficiency (HP:0004430)2.06066480
109Skin ulcer (HP:0200042)2.05538902
110Acute hepatic failure (HP:0006554)2.05211670
111Combined immunodeficiency (HP:0005387)2.04257647
112Anorexia (HP:0002039)2.03766264
113Osteolytic defects of the phalanges of the hand (HP:0009771)2.02206297
114Osteolytic defects of the hand bones (HP:0009699)2.02206297
115Abnormality of eosinophils (HP:0001879)2.01846286
116Petechiae (HP:0000967)2.01780029
117Arthralgia (HP:0002829)2.01603726
118Abnormality of the fingertips (HP:0001211)2.01492385
119Keratoconjunctivitis (HP:0001096)2.00762725
120Hypoplasia of the thymus (HP:0000778)2.00429714
121Porencephaly (HP:0002132)1.99209413
122Sepsis (HP:0100806)1.97633642
123Prolonged bleeding time (HP:0003010)1.97556431
124Mitral stenosis (HP:0001718)1.94943199
125Abnormal platelet volume (HP:0011876)1.93499403
126Peritonitis (HP:0002586)1.91453494
127Loss of speech (HP:0002371)1.90849999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.01546909
2MAP4K13.88148023
3FGFR43.02088255
4JAK33.00773685
5IKBKE2.87522576
6MAP3K142.86249111
7TBK12.83510699
8JAK12.73233333
9ERN12.73024849
10TXK2.58414746
11STK102.42848229
12BLK2.42839334
13KIT2.25588996
14TESK21.96631079
15PRPF4B1.96048425
16MAP3K131.95815213
17MAP3K101.90921993
18FGFR31.90891874
19IRAK41.83105148
20ZAP701.81312619
21TGFBR21.78103555
22TRIB31.71177138
23GRK71.69194262
24IKBKB1.67362747
25TNK21.66370349
26MAP3K111.64739987
27CSK1.62950391
28IRAK31.60700866
29ITK1.53700147
30PKN21.51061071
31EPHB11.50302684
32GRK61.45464472
33RIPK41.44144157
34LRRK21.40941797
35TAOK21.39712123
36HCK1.36075795
37SYK1.33965858
38CSF1R1.33540063
39LCK1.30878244
40TAOK11.29182267
41CDK121.26824314
42MARK31.23684830
43BTK1.23461932
44TTN1.23240530
45JAK21.21518908
46TAOK31.20517803
47PTK61.20291922
48SIK31.18401737
49RIPK11.15337068
50CHUK1.10697029
51MAP3K11.09420671
52BMPR21.09413436
53TEC1.06370471
54EEF2K1.04167461
55RPS6KA41.03033000
56EPHA31.01697768
57SIK10.93806066
58NME20.93663442
59NEK90.91683300
60PIM10.90609945
61MST40.90548944
62LYN0.86164441
63CAMK1D0.85701198
64NLK0.81731193
65STK40.80924379
66FES0.77044155
67PRKCQ0.73325316
68MAP2K30.72122087
69STK30.69340124
70CDC42BPA0.64114241
71SIK20.63772606
72TRPM70.63283551
73EGFR0.61191593
74CDK40.61068813
75FLT30.60456507
76CDK60.60346906
77MOS0.60194504
78PRKCH0.59451741
79PBK0.58832351
80PIK3CG0.58157464
81IRAK20.57893849
82SMG10.57825914
83PIM20.57803863
84YES10.56439507
85KDR0.55005068
86MAPK110.53661404
87BMX0.51224558
88MAP2K60.50108093
89MATK0.50083772
90PDGFRB0.48686104
91MAP3K70.47751820
92IRAK10.47541938
93TESK10.45612434
94FGR0.45442789
95ACVR1B0.45394749
96CAMK1G0.44214613
97ABL10.42444529
98PDK10.42339844
99ALK0.42191552
100SGK30.41417957
101CAMKK20.39668317
102MAP3K50.39056378
103MAP3K30.37882431
104MAPK40.36271251
105MAP3K80.35961548
106PRKD20.35309855
107BCKDK0.34254038
108MKNK20.33799971
109IGF1R0.33164458
110HIPK20.31176346
111PDPK10.30238060
112TGFBR10.29074252
113MAPK70.28567333
114STK240.28561170
115INSR0.28265856
116FYN0.28197281
117SCYL20.27371079
118PRKCD0.26465486
119MAPKAPK20.26324618
120EIF2AK20.25519698
121KSR20.24521319
122PAK40.24421077
123ADRBK20.23878658
124RPS6KA60.23637028
125CLK10.22406189
126MAP3K120.22222129
127RET0.21705226
128MAPK30.20795310
129MAP3K60.19754401
130DDR20.17407687

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.91749158
2Leishmaniasis_Homo sapiens_hsa051402.88304714
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.76663110
4Primary immunodeficiency_Homo sapiens_hsa053402.66955945
5Measles_Homo sapiens_hsa051622.58811816
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.55646367
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.47220401
8Osteoclast differentiation_Homo sapiens_hsa043802.36236713
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15455635
10B cell receptor signaling pathway_Homo sapiens_hsa046622.11383572
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05713428
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.04225957
13Influenza A_Homo sapiens_hsa051642.02230304
14Antigen processing and presentation_Homo sapiens_hsa046122.00905022
15Caffeine metabolism_Homo sapiens_hsa002321.89532839
16Herpes simplex infection_Homo sapiens_hsa051681.85927495
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80087223
18Graft-versus-host disease_Homo sapiens_hsa053321.76471618
19Toxoplasmosis_Homo sapiens_hsa051451.76008218
20Legionellosis_Homo sapiens_hsa051341.73984451
21TNF signaling pathway_Homo sapiens_hsa046681.72281024
22Allograft rejection_Homo sapiens_hsa053301.69954874
23Pertussis_Homo sapiens_hsa051331.68128910
24Malaria_Homo sapiens_hsa051441.65660028
25T cell receptor signaling pathway_Homo sapiens_hsa046601.62735011
26Tuberculosis_Homo sapiens_hsa051521.62331185
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61213160
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.50965082
29Hematopoietic cell lineage_Homo sapiens_hsa046401.47439298
30Hepatitis C_Homo sapiens_hsa051601.43967553
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38083066
32Hepatitis B_Homo sapiens_hsa051611.37514930
33Complement and coagulation cascades_Homo sapiens_hsa046101.36155377
34Apoptosis_Homo sapiens_hsa042101.34957393
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33108950
36Viral myocarditis_Homo sapiens_hsa054161.24574991
37Chemokine signaling pathway_Homo sapiens_hsa040621.21624736
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.11913540
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.09829563
40Acute myeloid leukemia_Homo sapiens_hsa052211.09698428
41Lysosome_Homo sapiens_hsa041421.07709463
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05947527
43Asthma_Homo sapiens_hsa053101.03449908
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01339746
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99692743
46Shigellosis_Homo sapiens_hsa051310.98488348
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.98197567
48African trypanosomiasis_Homo sapiens_hsa051430.96448564
49Chronic myeloid leukemia_Homo sapiens_hsa052200.95656095
50Salmonella infection_Homo sapiens_hsa051320.95464833
51Nitrogen metabolism_Homo sapiens_hsa009100.91741359
52Pancreatic cancer_Homo sapiens_hsa052120.91503573
53Other glycan degradation_Homo sapiens_hsa005110.88464516
54Prolactin signaling pathway_Homo sapiens_hsa049170.86869237
55Autoimmune thyroid disease_Homo sapiens_hsa053200.86738897
56Small cell lung cancer_Homo sapiens_hsa052220.86317499
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85379981
58Rheumatoid arthritis_Homo sapiens_hsa053230.85168550
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84926400
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84539936
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.84172314
62Arginine biosynthesis_Homo sapiens_hsa002200.81790377
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77418873
64Insulin resistance_Homo sapiens_hsa049310.75084584
65Platelet activation_Homo sapiens_hsa046110.72534355
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70546494
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69222062
68Phagosome_Homo sapiens_hsa041450.68259905
69ABC transporters_Homo sapiens_hsa020100.67429068
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66910519
71Viral carcinogenesis_Homo sapiens_hsa052030.65232133
72Amoebiasis_Homo sapiens_hsa051460.62331395
73Lysine degradation_Homo sapiens_hsa003100.62015089
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61571221
75Type I diabetes mellitus_Homo sapiens_hsa049400.56862708
76PPAR signaling pathway_Homo sapiens_hsa033200.56773146
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55517480
78Epstein-Barr virus infection_Homo sapiens_hsa051690.53029850
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52574799
80HIF-1 signaling pathway_Homo sapiens_hsa040660.52365388
81HTLV-I infection_Homo sapiens_hsa051660.52172619
82Endocytosis_Homo sapiens_hsa041440.52093546
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48394965
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.46606279
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44247340
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44159105
87Notch signaling pathway_Homo sapiens_hsa043300.43405098
88Non-small cell lung cancer_Homo sapiens_hsa052230.40561927
89mTOR signaling pathway_Homo sapiens_hsa041500.39910148
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.38763270
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38150015
92* Systemic lupus erythematosus_Homo sapiens_hsa053220.36818868
93VEGF signaling pathway_Homo sapiens_hsa043700.36303534
94Proteoglycans in cancer_Homo sapiens_hsa052050.35854726
95Galactose metabolism_Homo sapiens_hsa000520.35006947
96Type II diabetes mellitus_Homo sapiens_hsa049300.34993762
97Tryptophan metabolism_Homo sapiens_hsa003800.34232239
98Proteasome_Homo sapiens_hsa030500.34014409
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33738650
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33077254
101Fatty acid degradation_Homo sapiens_hsa000710.32552119
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31604344
103One carbon pool by folate_Homo sapiens_hsa006700.31551304
104FoxO signaling pathway_Homo sapiens_hsa040680.30246694
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30085241
106Selenocompound metabolism_Homo sapiens_hsa004500.29478396
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28869164
108MicroRNAs in cancer_Homo sapiens_hsa052060.28568825
109Prion diseases_Homo sapiens_hsa050200.27388540
110Prostate cancer_Homo sapiens_hsa052150.26131596
111Colorectal cancer_Homo sapiens_hsa052100.25262489
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25091166
113Peroxisome_Homo sapiens_hsa041460.24558142
114Bladder cancer_Homo sapiens_hsa052190.24097768
115Renal cell carcinoma_Homo sapiens_hsa052110.16232866
116Collecting duct acid secretion_Homo sapiens_hsa049660.15876840
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.12772777
118Sulfur metabolism_Homo sapiens_hsa009200.11923307
119Regulation of autophagy_Homo sapiens_hsa041400.11855669
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11475871
121Pentose phosphate pathway_Homo sapiens_hsa000300.09604255
122MAPK signaling pathway_Homo sapiens_hsa040100.07672052

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