TRIM16L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.30021483
2daunorubicin metabolic process (GO:0044597)8.30021483
3polyketide metabolic process (GO:0030638)8.30021483
4aminoglycoside antibiotic metabolic process (GO:0030647)7.33766637
5primary alcohol catabolic process (GO:0034310)4.61144870
6quinone metabolic process (GO:1901661)4.25804261
7behavioral response to nicotine (GO:0035095)4.07537526
8regulation of hippo signaling (GO:0035330)3.82692314
9cysteine metabolic process (GO:0006534)3.57851586
10kynurenine metabolic process (GO:0070189)3.56348712
11glycoside metabolic process (GO:0016137)3.43780275
12cellular ketone body metabolic process (GO:0046950)3.23592011
13L-fucose catabolic process (GO:0042355)3.22621747
14fucose catabolic process (GO:0019317)3.22621747
15L-fucose metabolic process (GO:0042354)3.22621747
16retinal metabolic process (GO:0042574)3.19487534
17flavonoid metabolic process (GO:0009812)3.14352472
18protein K6-linked ubiquitination (GO:0085020)3.04204267
19ketone body metabolic process (GO:1902224)3.00706072
20maturation of 5.8S rRNA (GO:0000460)3.00314008
21respiratory chain complex IV assembly (GO:0008535)2.97765271
22cornea development in camera-type eye (GO:0061303)2.97643435
23water-soluble vitamin biosynthetic process (GO:0042364)2.95008047
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88702840
25ATP synthesis coupled proton transport (GO:0015986)2.88104330
26energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88104330
27retinoic acid metabolic process (GO:0042573)2.87558752
28tryptophan catabolic process (GO:0006569)2.82408903
29indole-containing compound catabolic process (GO:0042436)2.82408903
30indolalkylamine catabolic process (GO:0046218)2.82408903
31proteasome assembly (GO:0043248)2.80397602
32ubiquinone biosynthetic process (GO:0006744)2.78886690
33protein complex biogenesis (GO:0070271)2.76805678
34mitochondrial respiratory chain complex assembly (GO:0033108)2.76793008
35mannosylation (GO:0097502)2.75806682
36mitochondrial respiratory chain complex I assembly (GO:0032981)2.75750541
37NADH dehydrogenase complex assembly (GO:0010257)2.75750541
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75750541
39DNA deamination (GO:0045006)2.74557333
40pseudouridine synthesis (GO:0001522)2.71860152
41piRNA metabolic process (GO:0034587)2.70625204
42response to pheromone (GO:0019236)2.70340142
43mitochondrial RNA metabolic process (GO:0000959)2.68952388
44cellular ketone metabolic process (GO:0042180)2.68584877
45tRNA modification (GO:0006400)2.65355375
46mitochondrion morphogenesis (GO:0070584)2.61191401
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58379834
48cellular aldehyde metabolic process (GO:0006081)2.57366126
49ubiquinone metabolic process (GO:0006743)2.56049710
50tRNA processing (GO:0008033)2.55345266
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.53737298
52response to growth hormone (GO:0060416)2.52932229
53cellular glucuronidation (GO:0052695)2.52502027
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50439598
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50306062
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50306062
57glucuronate metabolic process (GO:0019585)2.48806735
58uronic acid metabolic process (GO:0006063)2.48806735
59preassembly of GPI anchor in ER membrane (GO:0016254)2.48446318
60protein-cofactor linkage (GO:0018065)2.47068809
61electron transport chain (GO:0022900)2.46137728
62tRNA methylation (GO:0030488)2.44694855
63terpenoid biosynthetic process (GO:0016114)2.43372980
64cytochrome complex assembly (GO:0017004)2.43298217
65epithelial cilium movement (GO:0003351)2.43070884
66negative regulation of telomere maintenance (GO:0032205)2.41273245
67axonemal dynein complex assembly (GO:0070286)2.40727042
68peptidyl-histidine modification (GO:0018202)2.39671527
69secondary metabolic process (GO:0019748)2.36327441
70tryptophan metabolic process (GO:0006568)2.35752988
71response to nitrosative stress (GO:0051409)2.35181687
72indolalkylamine metabolic process (GO:0006586)2.34709317
73respiratory electron transport chain (GO:0022904)2.33070564
74regulation of cilium movement (GO:0003352)2.32275710
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.30820162
76protein import into peroxisome matrix (GO:0016558)2.30745426
77response to food (GO:0032094)2.30130677
78protein neddylation (GO:0045116)2.26017141
79drug transmembrane transport (GO:0006855)2.24909343
80cAMP catabolic process (GO:0006198)2.20526453
81negative regulation of T cell differentiation in thymus (GO:0033085)2.20388071
82histone-serine phosphorylation (GO:0035404)2.19656438
83intracellular protein transmembrane import (GO:0044743)2.16687936
84replication fork processing (GO:0031297)2.16478464
85L-methionine salvage (GO:0071267)2.16264625
86L-methionine biosynthetic process (GO:0071265)2.16264625
87amino acid salvage (GO:0043102)2.16264625
88tRNA metabolic process (GO:0006399)2.16263670
89positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.16129986
90opioid receptor signaling pathway (GO:0038003)2.15803594
91fat-soluble vitamin catabolic process (GO:0042363)2.15706754
92vitamin catabolic process (GO:0009111)2.15706754
93protein polyglutamylation (GO:0018095)2.14846200
94diterpenoid biosynthetic process (GO:0016102)2.14326931
95spindle assembly involved in mitosis (GO:0090307)2.13945036
96indole-containing compound metabolic process (GO:0042430)2.13839873
97negative regulation of reactive oxygen species metabolic process (GO:2000378)2.13560827
98nonmotile primary cilium assembly (GO:0035058)2.12928031
99cellular biogenic amine catabolic process (GO:0042402)2.12770774
100amine catabolic process (GO:0009310)2.12770774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74055285
2ZNF274_21170338_ChIP-Seq_K562_Hela3.73206643
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.29632610
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07727359
5VDR_22108803_ChIP-Seq_LS180_Human2.95488117
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84525062
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.66556975
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.44783488
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36681563
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32950755
11ELK1_19687146_ChIP-ChIP_HELA_Human2.27656661
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22551494
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19328853
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.04416688
15MYC_18940864_ChIP-ChIP_HL60_Human2.04268156
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.02950443
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96867401
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86128060
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78889139
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70987477
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67748697
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66564635
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65216309
24ER_23166858_ChIP-Seq_MCF-7_Human1.62402718
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60647860
26GBX2_23144817_ChIP-Seq_PC3_Human1.56569367
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.54739727
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52492478
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.51603088
30VDR_23849224_ChIP-Seq_CD4+_Human1.48012502
31TP53_22573176_ChIP-Seq_HFKS_Human1.47915659
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45687179
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44916751
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43333546
35DCP1A_22483619_ChIP-Seq_HELA_Human1.41999826
36EWS_26573619_Chip-Seq_HEK293_Human1.40663432
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35733705
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.34878173
39HOXB7_26014856_ChIP-Seq_BT474_Human1.34238973
40GABP_19822575_ChIP-Seq_HepG2_Human1.33263466
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32850665
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.32149385
43IRF1_19129219_ChIP-ChIP_H3396_Human1.30468854
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30345054
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.30345054
46FUS_26573619_Chip-Seq_HEK293_Human1.29862726
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29855748
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26600530
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26008684
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25380379
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.21857910
52AR_20517297_ChIP-Seq_VCAP_Human1.21190327
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21169221
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20991180
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20148577
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.19641551
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16356975
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15503708
59* GATA4_25053715_ChIP-Seq_YYC3_Human1.13646339
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08250968
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.07625709
62KDM5A_27292631_Chip-Seq_BREAST_Human1.06110468
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.05958391
64* CJUN_26792858_Chip-Seq_BT549_Human1.04820877
65AHR_22903824_ChIP-Seq_MCF-7_Human1.04685478
66ERA_21632823_ChIP-Seq_H3396_Human1.03317086
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01716906
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00927586
69ELF5_23300383_ChIP-Seq_T47D_Human1.00097713
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99984787
71TTF2_22483619_ChIP-Seq_HELA_Human0.98857622
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97404190
73E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97088045
74TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96838416
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94483947
76FOXP3_21729870_ChIP-Seq_TREG_Human0.93887085
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92878340
78* P53_21459846_ChIP-Seq_SAOS-2_Human0.90779293
79MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90273679
80XRN2_22483619_ChIP-Seq_HELA_Human0.90224343
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89132719
82ZNF263_19887448_ChIP-Seq_K562_Human0.87054524
83AR_25329375_ChIP-Seq_VCAP_Human0.86734324
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.86459027
85NANOG_19829295_ChIP-Seq_ESCs_Human0.86192167
86SOX2_19829295_ChIP-Seq_ESCs_Human0.86192167
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86187347
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.86081296
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85016346
90YY1_21170310_ChIP-Seq_MESCs_Mouse0.83870294
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83764936
92P300_19829295_ChIP-Seq_ESCs_Human0.82891733
93NCOR_22424771_ChIP-Seq_293T_Human0.82817292
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81603531
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81484226
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81484226
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79277928
98IGF1R_20145208_ChIP-Seq_DFB_Human0.79260568
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79120472
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78884992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.66233778
2MP0003806_abnormal_nucleotide_metabolis3.16616475
3MP0002102_abnormal_ear_morphology2.53377006
4MP0003646_muscle_fatigue2.47091815
5MP0003136_yellow_coat_color2.29792784
6MP0002938_white_spotting2.10628595
7MP0000383_abnormal_hair_follicle2.09807937
8MP0003186_abnormal_redox_activity1.94408640
9MP0002234_abnormal_pharynx_morphology1.91834403
10MP0000427_abnormal_hair_cycle1.90087070
11MP0002837_dystrophic_cardiac_calcinosis1.86856719
12MP0008872_abnormal_physiological_respon1.86628439
13MP0002736_abnormal_nociception_after1.77095998
14MP0004133_heterotaxia1.76573360
15MP0008058_abnormal_DNA_repair1.71764600
16MP0001968_abnormal_touch/_nociception1.71541536
17MP0000579_abnormal_nail_morphology1.70241605
18MP0002876_abnormal_thyroid_physiology1.69181420
19MP0003950_abnormal_plasma_membrane1.68656449
20MP0002160_abnormal_reproductive_system1.64841107
21MP0000372_irregular_coat_pigmentation1.63308247
22MP0005551_abnormal_eye_electrophysiolog1.61697309
23MP0003195_calcinosis1.59756682
24MP0001348_abnormal_lacrimal_gland1.59433195
25MP0005645_abnormal_hypothalamus_physiol1.50337920
26MP0010678_abnormal_skin_adnexa1.48412401
27MP0003283_abnormal_digestive_organ1.46339877
28MP0009046_muscle_twitch1.46252063
29MP0004142_abnormal_muscle_tone1.37260703
30MP0004233_abnormal_muscle_weight1.37168631
31MP0008877_abnormal_DNA_methylation1.36884099
32MP0000647_abnormal_sebaceous_gland1.34990812
33MP0006072_abnormal_retinal_apoptosis1.34858732
34MP0009780_abnormal_chondrocyte_physiolo1.34682409
35MP0005332_abnormal_amino_acid1.28588645
36MP0002928_abnormal_bile_duct1.27065891
37MP0001529_abnormal_vocalization1.26421224
38MP0002638_abnormal_pupillary_reflex1.24632042
39MP0008775_abnormal_heart_ventricle1.24607495
40MP0005389_reproductive_system_phenotype1.24583150
41MP0003011_delayed_dark_adaptation1.23574057
42MP0003718_maternal_effect1.22387142
43MP0004043_abnormal_pH_regulation1.18113352
44MP0010030_abnormal_orbit_morphology1.17554853
45MP0005253_abnormal_eye_physiology1.16013570
46MP0001661_extended_life_span1.13858797
47MP0003937_abnormal_limbs/digits/tail_de1.13709801
48MP0005083_abnormal_biliary_tract1.11317735
49MP0009379_abnormal_foot_pigmentation1.09971361
50MP0000013_abnormal_adipose_tissue1.08979290
51MP0000749_muscle_degeneration1.08429876
52MP0005195_abnormal_posterior_eye1.08241814
53MP0000762_abnormal_tongue_morphology1.07866048
54MP0000631_abnormal_neuroendocrine_gland1.06796667
55MP0004147_increased_porphyrin_level1.03982463
56MP0003252_abnormal_bile_duct1.03688590
57MP0002653_abnormal_ependyma_morphology1.03505416
58MP0002272_abnormal_nervous_system1.02773139
59MP0005646_abnormal_pituitary_gland1.01282420
60MP0002909_abnormal_adrenal_gland1.00835792
61MP0003693_abnormal_embryo_hatching1.00558618
62MP0003786_premature_aging1.00109252
63MP0001905_abnormal_dopamine_level0.99204493
64MP0001485_abnormal_pinna_reflex0.98790754
65MP0005408_hypopigmentation0.97508555
66MP0009053_abnormal_anal_canal0.97084217
67MP0003137_abnormal_impulse_conducting0.96785479
68MP0000538_abnormal_urinary_bladder0.96595176
69MP0009745_abnormal_behavioral_response0.95820998
70MP0010094_abnormal_chromosome_stability0.95054150
71MP0004019_abnormal_vitamin_homeostasis0.93122038
72MP0000569_abnormal_digit_pigmentation0.90740411
73MP0004215_abnormal_myocardial_fiber0.90345240
74MP0004145_abnormal_muscle_electrophysio0.88665639
75MP0009697_abnormal_copulation0.88521993
76MP0004885_abnormal_endolymph0.87521325
77MP0003755_abnormal_palate_morphology0.87085954
78MP0000750_abnormal_muscle_regeneration0.85873581
79MP0000358_abnormal_cell_content/0.85681755
80MP0001919_abnormal_reproductive_system0.83814488
81MP0001986_abnormal_taste_sensitivity0.82945963
82MP0005174_abnormal_tail_pigmentation0.82562495
83MP0005085_abnormal_gallbladder_physiolo0.82180940
84MP0002184_abnormal_innervation0.81551286
85MP0005266_abnormal_metabolism0.81514876
86MP0006036_abnormal_mitochondrial_physio0.81075075
87MP0008007_abnormal_cellular_replicative0.79954421
88MP0005391_vision/eye_phenotype0.79148888
89MP0002332_abnormal_exercise_endurance0.77814670
90MP0002733_abnormal_thermal_nociception0.77188656
91MP0004924_abnormal_behavior0.76787871
92MP0005386_behavior/neurological_phenoty0.76787871
93MP0002735_abnormal_chemical_nociception0.76769441
94MP0006276_abnormal_autonomic_nervous0.76372007
95MP0001502_abnormal_circadian_rhythm0.75644403
96MP0001324_abnormal_eye_pigmentation0.75525725
97MP0002697_abnormal_eye_size0.75400849
98MP0005171_absent_coat_pigmentation0.74534947
99MP0001286_abnormal_eye_development0.74102694
100MP0002210_abnormal_sex_determination0.73970735

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.33071480
2Pancreatic cysts (HP:0001737)3.78968516
3Molar tooth sign on MRI (HP:0002419)3.74030602
4Abnormality of midbrain morphology (HP:0002418)3.74030602
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.58808007
6Abnormality of alanine metabolism (HP:0010916)3.58808007
7Hyperalaninemia (HP:0003348)3.58808007
8Pancreatic fibrosis (HP:0100732)3.56989349
9Cerebellar dysplasia (HP:0007033)3.37257537
10True hermaphroditism (HP:0010459)3.31552321
11Nephronophthisis (HP:0000090)3.02894153
12Tubular atrophy (HP:0000092)3.00770931
13Abnormality of the renal cortex (HP:0011035)2.89856723
14Congenital stationary night blindness (HP:0007642)2.89160310
15Severe muscular hypotonia (HP:0006829)2.69253093
16Congenital, generalized hypertrichosis (HP:0004540)2.65451571
17Increased CSF lactate (HP:0002490)2.64317011
18Pendular nystagmus (HP:0012043)2.64271248
19Concave nail (HP:0001598)2.61086128
20Hepatic necrosis (HP:0002605)2.60364403
21Large for gestational age (HP:0001520)2.58622313
22Sclerocornea (HP:0000647)2.58539456
23Mitochondrial inheritance (HP:0001427)2.56676715
24Abnormality of the renal medulla (HP:0100957)2.54683868
25Hepatocellular necrosis (HP:0001404)2.47683931
26Chorioretinal atrophy (HP:0000533)2.46087359
27Increased hepatocellular lipid droplets (HP:0006565)2.42301738
28Lipid accumulation in hepatocytes (HP:0006561)2.42185006
29Lissencephaly (HP:0001339)2.40975586
30Acute necrotizing encephalopathy (HP:0006965)2.36859591
31Abnormal mitochondria in muscle tissue (HP:0008316)2.36406937
32Renal cortical cysts (HP:0000803)2.33809361
33Cystic liver disease (HP:0006706)2.32944414
34Birth length less than 3rd percentile (HP:0003561)2.32701157
35Abnormality of the pons (HP:0007361)2.18908942
36Absent thumb (HP:0009777)2.17729706
37Partial agenesis of the corpus callosum (HP:0001338)2.17669833
38Hypoplasia of the pons (HP:0012110)2.16060109
39Medial flaring of the eyebrow (HP:0010747)2.15826139
40Furrowed tongue (HP:0000221)2.15558110
41Testicular atrophy (HP:0000029)2.13692882
42Adrenal hypoplasia (HP:0000835)2.13608088
43Keratoconus (HP:0000563)2.13118413
44Increased corneal curvature (HP:0100692)2.13118413
45Abnormal respiratory motile cilium morphology (HP:0005938)2.12431542
46Abnormal respiratory epithelium morphology (HP:0012253)2.12431542
47Increased serum lactate (HP:0002151)2.11672270
48Abnormal number of erythroid precursors (HP:0012131)2.10668137
49Retinal dysplasia (HP:0007973)2.07992305
50Acute encephalopathy (HP:0006846)2.06426162
51Abnormality of cells of the erythroid lineage (HP:0012130)2.05208330
52Absent/shortened dynein arms (HP:0200106)2.04807817
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.04807817
54Hyperventilation (HP:0002883)2.03424563
55Aplasia/hypoplasia of the uterus (HP:0008684)2.01752375
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.00255281
57Aplasia/Hypoplasia of the tongue (HP:0010295)1.99157437
58Pachygyria (HP:0001302)1.94286960
59Chronic hepatic failure (HP:0100626)1.90593925
60Abnormality of the carotid arteries (HP:0005344)1.90526310
61Tongue fasciculations (HP:0001308)1.88866815
62Renal Fanconi syndrome (HP:0001994)1.87632406
63Occipital encephalocele (HP:0002085)1.86232537
64Progressive macrocephaly (HP:0004481)1.85971364
65Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85449591
66Microretrognathia (HP:0000308)1.84629071
67Chromsome breakage (HP:0040012)1.83013477
68Aplasia/Hypoplasia of the fibula (HP:0006492)1.82499691
69Attenuation of retinal blood vessels (HP:0007843)1.81860466
70Aplasia/Hypoplasia of the patella (HP:0006498)1.81706124
71Elfin facies (HP:0004428)1.81245206
72Patellar aplasia (HP:0006443)1.79975712
73Abnormal ciliary motility (HP:0012262)1.77420085
74Hypoplasia of the uterus (HP:0000013)1.76736926
75Fibular aplasia (HP:0002990)1.76596599
76Optic disc pallor (HP:0000543)1.75725936
77Brittle hair (HP:0002299)1.75077053
78Lactic acidosis (HP:0003128)1.74429302
79Tachypnea (HP:0002789)1.72904563
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.72873573
81Abnormality of the ileum (HP:0001549)1.72831576
82Male pseudohermaphroditism (HP:0000037)1.72755268
83Inability to walk (HP:0002540)1.70956004
84Optic nerve hypoplasia (HP:0000609)1.70607216
85Abnormal biliary tract physiology (HP:0012439)1.67533792
86Bile duct proliferation (HP:0001408)1.67533792
87Meckel diverticulum (HP:0002245)1.66149314
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.63732894
89Bilateral microphthalmos (HP:0007633)1.62811280
90Duplicated collecting system (HP:0000081)1.62470251
91Lethargy (HP:0001254)1.61988568
92Increased intramyocellular lipid droplets (HP:0012240)1.61763164
93Ketoacidosis (HP:0001993)1.61720970
94Progressive inability to walk (HP:0002505)1.60854858
95Gait imbalance (HP:0002141)1.60537558
96Delayed gross motor development (HP:0002194)1.60235357
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59440513
98Anencephaly (HP:0002323)1.58733095
99Disproportionate short-trunk short stature (HP:0003521)1.57759431
100Congenital primary aphakia (HP:0007707)1.57164307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R2.97890883
2ZAK2.95154299
3TLK12.88023107
4ERBB42.86246470
5FRK2.75480867
6BMPR1B2.53445011
7ADRBK22.45322935
8MET2.40634161
9IRAK32.23589830
10ACVR1B2.13139512
11EPHA22.10834115
12PBK2.10631445
13WNK42.01758003
14VRK21.91587718
15BRSK21.87411749
16LIMK11.84862488
17CASK1.83023103
18MAPKAPK31.67143191
19WEE11.60431616
20GRK11.58855990
21NUAK11.51440129
22TSSK61.50755112
23PNCK1.48863283
24NEK11.46855815
25EIF2AK11.44712572
26PHKG11.42962849
27PHKG21.42962849
28TRIM281.42459426
29MAP4K21.39451792
30PINK11.38621137
31NME11.32164273
32NEK21.31905302
33WNK31.30727291
34PRKCI1.29837029
35BUB11.26563206
36MUSK1.19542117
37MAPKAPK51.14103229
38ADRBK11.14100039
39CAMKK21.13848537
40STK391.11016593
41STK161.04486774
42RPS6KB21.04190481
43CDK81.02612536
44INSRR1.02270866
45BRSK10.98809910
46IRAK10.98609221
47MST40.94798048
48TTN0.92345111
49VRK10.90744697
50TGFBR10.89878038
51MAP2K70.88692350
52MAPK150.87408183
53FLT30.82993096
54MAP2K10.82248761
55CHEK20.80579007
56MAP3K120.80241162
57PLK10.77946974
58NME20.77401141
59PLK30.75481568
60PRKCE0.75228341
61CAMK2G0.72259174
62TRPM70.71921653
63TAF10.70088166
64MAP2K20.69812849
65AURKA0.68229123
66MAPK130.67736648
67OBSCN0.66318118
68ABL20.66034255
69CAMK2B0.63335671
70CAMK2D0.63294810
71ERBB30.61324458
72TTK0.58804864
73RPS6KA50.57639000
74CSNK1G30.57043583
75STK38L0.56353460
76AURKB0.55098596
77BCR0.53577392
78PIM20.53508109
79PTK2B0.53293142
80DAPK20.51160310
81PLK40.50225777
82PLK20.49493735
83SRPK10.47903144
84PTK20.46982654
85PAK30.46981333
86CSNK1G20.44494712
87DYRK20.43438506
88BCKDK0.42887676
89CSNK1A1L0.42397314
90AKT20.40871643
91CAMK2A0.40622497
92PRKCG0.40358887
93MAPK110.38863300
94CSNK1G10.38790186
95OXSR10.37054029
96MAP2K60.36739226
97MAP3K90.36634020
98MELK0.36109149
99STK380.35325573
100BRAF0.35283398

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.00269032
2Selenocompound metabolism_Homo sapiens_hsa004502.88102841
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71293339
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67591292
5Oxidative phosphorylation_Homo sapiens_hsa001902.44352366
6Proteasome_Homo sapiens_hsa030502.24872294
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.08771256
8Nitrogen metabolism_Homo sapiens_hsa009101.90206310
9Parkinsons disease_Homo sapiens_hsa050121.88793116
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88035532
11Ribosome_Homo sapiens_hsa030101.83924635
12Homologous recombination_Homo sapiens_hsa034401.80322121
13Chemical carcinogenesis_Homo sapiens_hsa052041.79262055
14Tryptophan metabolism_Homo sapiens_hsa003801.69784545
15One carbon pool by folate_Homo sapiens_hsa006701.67440559
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66170994
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59336500
18Protein export_Homo sapiens_hsa030601.55505911
19RNA polymerase_Homo sapiens_hsa030201.53901711
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52886438
21Linoleic acid metabolism_Homo sapiens_hsa005911.52170777
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45958026
23Nucleotide excision repair_Homo sapiens_hsa034201.43804291
24Glutathione metabolism_Homo sapiens_hsa004801.43202076
25Fanconi anemia pathway_Homo sapiens_hsa034601.42891794
26Huntingtons disease_Homo sapiens_hsa050161.42092665
27Sulfur relay system_Homo sapiens_hsa041221.40850050
28Alzheimers disease_Homo sapiens_hsa050101.38981322
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38787246
30Phototransduction_Homo sapiens_hsa047441.38767333
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38670413
32Folate biosynthesis_Homo sapiens_hsa007901.36105730
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35597918
34Sulfur metabolism_Homo sapiens_hsa009201.34632302
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34400387
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31838720
37Cardiac muscle contraction_Homo sapiens_hsa042601.30600615
38Basal transcription factors_Homo sapiens_hsa030221.27998815
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.25733206
40Pyrimidine metabolism_Homo sapiens_hsa002401.25643243
41beta-Alanine metabolism_Homo sapiens_hsa004101.21252344
42Butanoate metabolism_Homo sapiens_hsa006501.17001670
43ABC transporters_Homo sapiens_hsa020101.15820230
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13606834
45Peroxisome_Homo sapiens_hsa041461.10281273
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10193166
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.09973300
48Pyruvate metabolism_Homo sapiens_hsa006201.09271223
49Mismatch repair_Homo sapiens_hsa034301.08676521
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08000190
51Retinol metabolism_Homo sapiens_hsa008301.07080512
52Fructose and mannose metabolism_Homo sapiens_hsa000511.04231734
53Histidine metabolism_Homo sapiens_hsa003401.03059069
54Caffeine metabolism_Homo sapiens_hsa002321.01258954
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.99501879
56RNA degradation_Homo sapiens_hsa030180.98646981
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97621695
58Ether lipid metabolism_Homo sapiens_hsa005650.97605515
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91484087
60Arachidonic acid metabolism_Homo sapiens_hsa005900.90473044
61Vitamin B6 metabolism_Homo sapiens_hsa007500.89853638
62Purine metabolism_Homo sapiens_hsa002300.88079704
63Metabolic pathways_Homo sapiens_hsa011000.87998555
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.87672195
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86115821
66Steroid biosynthesis_Homo sapiens_hsa001000.84867090
67Tyrosine metabolism_Homo sapiens_hsa003500.84218712
68Ovarian steroidogenesis_Homo sapiens_hsa049130.83454667
69Glycerolipid metabolism_Homo sapiens_hsa005610.82155524
70Pentose phosphate pathway_Homo sapiens_hsa000300.81813536
71DNA replication_Homo sapiens_hsa030300.81721209
72Galactose metabolism_Homo sapiens_hsa000520.81156785
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77013993
74Starch and sucrose metabolism_Homo sapiens_hsa005000.75522744
75RNA transport_Homo sapiens_hsa030130.74323577
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71754587
77Non-homologous end-joining_Homo sapiens_hsa034500.68790819
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68145107
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66673642
80Phenylalanine metabolism_Homo sapiens_hsa003600.61070424
81Arginine and proline metabolism_Homo sapiens_hsa003300.60219080
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.58622532
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55759962
84Hippo signaling pathway_Homo sapiens_hsa043900.54874448
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54805632
86Propanoate metabolism_Homo sapiens_hsa006400.54729462
87Carbon metabolism_Homo sapiens_hsa012000.53673663
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53009848
89Nicotine addiction_Homo sapiens_hsa050330.52962031
90N-Glycan biosynthesis_Homo sapiens_hsa005100.52887924
91Base excision repair_Homo sapiens_hsa034100.52621673
92Biosynthesis of amino acids_Homo sapiens_hsa012300.50727973
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45039675
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44967315
95Fatty acid degradation_Homo sapiens_hsa000710.44104537
96Morphine addiction_Homo sapiens_hsa050320.43007079
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42172735
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39072834
99Basal cell carcinoma_Homo sapiens_hsa052170.38280609
100Fatty acid elongation_Homo sapiens_hsa000620.37079361

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