TRIM16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)5.92673807
2polyketide metabolic process (GO:0030638)5.92673807
3doxorubicin metabolic process (GO:0044598)5.92673807
4aminoglycoside antibiotic metabolic process (GO:0030647)5.18523100
5hemidesmosome assembly (GO:0031581)5.15325318
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.04468413
7wound healing, spreading of epidermal cells (GO:0035313)4.48838596
8cell adhesion mediated by integrin (GO:0033627)4.47657007
9keratinization (GO:0031424)4.39054275
10establishment of skin barrier (GO:0061436)4.24901825
11regulation of water loss via skin (GO:0033561)4.17855597
12vascular endothelial growth factor signaling pathway (GO:0038084)4.10933853
13lymph vessel development (GO:0001945)4.05466551
14negative regulation of keratinocyte proliferation (GO:0010839)3.99055945
15wound healing, spreading of cells (GO:0044319)3.73751111
16positive regulation of endothelial cell apoptotic process (GO:2000353)3.72151885
17primary alcohol catabolic process (GO:0034310)3.69354364
18chondrocyte proliferation (GO:0035988)3.61579493
19gap junction assembly (GO:0016264)3.60457082
20plasma membrane repair (GO:0001778)3.59015132
21COPI coating of Golgi vesicle (GO:0048205)3.50325766
22Golgi transport vesicle coating (GO:0048200)3.50325766
23skin morphogenesis (GO:0043589)3.50120108
24epithelial cell-cell adhesion (GO:0090136)3.47806592
25endodermal cell differentiation (GO:0035987)3.41152706
26cell-substrate junction assembly (GO:0007044)3.38490741
27keratinocyte development (GO:0003334)3.36208415
28regulation of hippo signaling (GO:0035330)3.33643542
29ectoderm development (GO:0007398)3.22746474
30desmosome organization (GO:0002934)3.22619750
31keratinocyte differentiation (GO:0030216)3.16684130
32regulation of transforming growth factor beta2 production (GO:0032909)3.15480342
33surfactant homeostasis (GO:0043129)3.15286019
34cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.11442600
35renal filtration (GO:0097205)3.08612909
36mesodermal cell differentiation (GO:0048333)3.08420877
37pentose-phosphate shunt (GO:0006098)3.05589919
38NADPH regeneration (GO:0006740)3.03982874
39morphogenesis of an endothelium (GO:0003159)2.99362140
40endothelial tube morphogenesis (GO:0061154)2.99362140
41angiogenesis involved in wound healing (GO:0060055)2.98527127
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.98368186
43negative regulation of fatty acid transport (GO:2000192)2.98172119
44basement membrane organization (GO:0071711)2.95667127
45collagen fibril organization (GO:0030199)2.93374646
46establishment of endothelial barrier (GO:0061028)2.92479898
47regulation of keratinocyte proliferation (GO:0010837)2.92321617
48diterpenoid biosynthetic process (GO:0016102)2.91643744
49intestinal epithelial cell development (GO:0060576)2.91064870
50membrane budding (GO:0006900)2.90612241
51endothelium development (GO:0003158)2.89518682
52lymphangiogenesis (GO:0001946)2.88909361
53positive regulation of blood vessel endothelial cell migration (GO:0043536)2.86574599
54membrane raft organization (GO:0031579)2.85709807
55nucleobase-containing small molecule interconversion (GO:0015949)2.84724823
56protein heterotetramerization (GO:0051290)2.83390976
57epidermis development (GO:0008544)2.83155884
58muscle filament sliding (GO:0030049)2.81881045
59actin-myosin filament sliding (GO:0033275)2.81881045
60proteasome assembly (GO:0043248)2.81441164
61establishment of planar polarity (GO:0001736)2.79824360
62establishment of tissue polarity (GO:0007164)2.79824360
63regulation of skeletal muscle contraction (GO:0014819)2.79040644
64regulation of vasculogenesis (GO:2001212)2.77750823
65multicellular organismal water homeostasis (GO:0050891)2.76583101
66mRNA transcription (GO:0009299)2.75940908
67cell migration involved in sprouting angiogenesis (GO:0002042)2.75079852
68substrate-dependent cell migration (GO:0006929)2.74762745
69regulation of integrin-mediated signaling pathway (GO:2001044)2.74685377
70quinone metabolic process (GO:1901661)2.69116289
71retinal metabolic process (GO:0042574)2.68009474
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67579274
73tRNA methylation (GO:0030488)2.67403906
74germ cell migration (GO:0008354)2.67398414
75negative regulation of chondrocyte differentiation (GO:0032331)2.66512783
76definitive hemopoiesis (GO:0060216)2.66340175
77fibroblast migration (GO:0010761)2.66192360
78stress fiber assembly (GO:0043149)2.66145573
79blood vessel maturation (GO:0001955)2.65651552
80terpenoid biosynthetic process (GO:0016114)2.65283126
81hepatocyte apoptotic process (GO:0097284)2.64715048
82positive regulation of epithelial to mesenchymal transition (GO:0010718)2.64653610
83mitotic nuclear envelope reassembly (GO:0007084)2.63826479
84nuclear envelope reassembly (GO:0031468)2.63826479
85glomerular filtration (GO:0003094)2.63244279
86actin filament depolymerization (GO:0030042)2.61824354
87epidermal cell differentiation (GO:0009913)2.60935981
88blood vessel endothelial cell migration (GO:0043534)2.60758633
89peptidyl-proline hydroxylation (GO:0019511)2.59059674
90negative regulation of phagocytosis (GO:0050765)2.58790401
91negative regulation of smooth muscle cell migration (GO:0014912)2.58086320
92actin-mediated cell contraction (GO:0070252)2.57826144
93endocardial cushion development (GO:0003197)2.57448390
94glycoside metabolic process (GO:0016137)2.57233980
95glucose catabolic process (GO:0006007)2.53352139
96retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53011961
97substrate adhesion-dependent cell spreading (GO:0034446)2.49928727
98polarized epithelial cell differentiation (GO:0030859)2.48835354
99hair cycle (GO:0042633)2.48394178
100molting cycle (GO:0042303)2.48394178
101positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.47441949
102protein hydroxylation (GO:0018126)2.47427971
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.47427586
104ribosomal small subunit assembly (GO:0000028)2.46936816
105protein heterotrimerization (GO:0070208)2.46587458
106dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46273866
107apoptotic cell clearance (GO:0043277)2.46148445
108blood vessel remodeling (GO:0001974)2.44618406
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44318822
110regulation of tight junction assembly (GO:2000810)2.44276072
111protein localization to cell surface (GO:0034394)2.43670233
112hippo signaling (GO:0035329)2.41966933
113regulation of endothelial cell differentiation (GO:0045601)2.41853182
114response to laminar fluid shear stress (GO:0034616)2.40951596
115vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.40924456
116endothelial cell morphogenesis (GO:0001886)2.40527197
117positive regulation of vasculogenesis (GO:2001214)2.39390759
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.39197151
119positive regulation of odontogenesis (GO:0042482)2.38680881
120keratinocyte proliferation (GO:0043616)2.38547747
121positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.38075381
122protein retention in ER lumen (GO:0006621)2.37963095
123viral transcription (GO:0019083)2.37213900
124ganglion development (GO:0061548)2.35607963
125virion attachment to host cell (GO:0019062)2.35401174
126adhesion of symbiont to host cell (GO:0044650)2.35401174
127regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.33980540
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33652474
129nucleotide-sugar biosynthetic process (GO:0009226)2.33024957
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.32640999
131regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.32566525
132* positive regulation of epidermal cell differentiation (GO:0045606)2.32520196
133GDP-mannose metabolic process (GO:0019673)2.32466774
134ribosome assembly (GO:0042255)2.32114351
135negative regulation of stem cell proliferation (GO:2000647)2.32073168
136axon extension involved in axon guidance (GO:0048846)2.31912218
137neuron projection extension involved in neuron projection guidance (GO:1902284)2.31912218
138branching involved in salivary gland morphogenesis (GO:0060445)2.30248964
139positive regulation of osteoblast proliferation (GO:0033690)2.29672675
140sequestering of extracellular ligand from receptor (GO:0035581)2.29576886
141adherens junction assembly (GO:0034333)2.29160398
142translational termination (GO:0006415)2.28898473
143extracellular matrix disassembly (GO:0022617)2.28801031
144peptide cross-linking (GO:0018149)2.28498565
145regulation of chemokine secretion (GO:0090196)2.28173152
146cellular aldehyde metabolic process (GO:0006081)2.27743830
147skeletal muscle adaptation (GO:0043501)2.27071743
148collagen metabolic process (GO:0032963)2.27059404
149regulation of cell proliferation involved in kidney development (GO:1901722)2.26920321
150actin filament-based movement (GO:0030048)2.26910035
151T cell apoptotic process (GO:0070231)2.25731590
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.24095440
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.24095440
154negative regulation of interleukin-8 production (GO:0032717)2.23986180
155asymmetric protein localization (GO:0008105)2.23888704
156COPII vesicle coating (GO:0048208)2.23491111
157regulation of protein heterodimerization activity (GO:0043497)2.23344259
158tRNA aminoacylation for protein translation (GO:0006418)2.23314888
159tight junction assembly (GO:0070830)2.19841360
160retinoic acid metabolic process (GO:0042573)2.19414886
161cardiac right ventricle morphogenesis (GO:0003215)2.19223955
1624-hydroxyproline metabolic process (GO:0019471)2.18326134
163tRNA aminoacylation (GO:0043039)2.16100882
164amino acid activation (GO:0043038)2.16100882
165regulation of cardioblast differentiation (GO:0051890)2.15470874
166cell-cell junction assembly (GO:0007043)2.14381708
167protein localization to microtubule (GO:0035372)2.13822289
168lung lobe morphogenesis (GO:0060463)2.12179760
169cysteine metabolic process (GO:0006534)2.12075119
170* positive regulation of epidermis development (GO:0045684)2.12018362
171water homeostasis (GO:0030104)2.10383120
172L-serine transport (GO:0015825)2.09434527
173notochord development (GO:0030903)2.08565047
174ribosome biogenesis (GO:0042254)2.07409661
175glomerular epithelial cell development (GO:0072310)2.07127510
176flavonoid metabolic process (GO:0009812)2.07051417
177pentose metabolic process (GO:0019321)2.07000811
178glomerular visceral epithelial cell development (GO:0072015)2.06742878
179protein K6-linked ubiquitination (GO:0085020)2.06180951
180cell junction assembly (GO:0034329)2.05719433
181response to food (GO:0032094)2.05645769
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.05187663
183morphogenesis of embryonic epithelium (GO:0016331)2.04506591
184ER overload response (GO:0006983)2.03728369
185negative regulation of protein localization to cell surface (GO:2000009)2.02727097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.64069533
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.78166017
3* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.17237406
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.74251699
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07206356
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.85150723
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.69522658
8CLOCK_20551151_ChIP-Seq_293T_Human2.50069192
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39031027
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36744011
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.26475159
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.26475159
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26291274
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.23104354
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21572954
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.18934242
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.16947113
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.16378075
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.14341481
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.13429491
21AR_21909140_ChIP-Seq_LNCAP_Human2.03677354
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.03320995
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02718213
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01708295
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99813581
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97442130
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.97065638
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91202273
29DCP1A_22483619_ChIP-Seq_HELA_Human1.90999813
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.84484246
31* SOX2_20726797_ChIP-Seq_SW620_Human1.82949084
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80906601
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79101786
34CJUN_26792858_Chip-Seq_BT549_Human1.78082735
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76151135
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75698593
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75383527
38E2F7_22180533_ChIP-Seq_HELA_Human1.73758411
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70992614
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.67142912
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66090543
42ATF3_27146783_Chip-Seq_COLON_Human1.63851691
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63240332
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.61390160
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.61283881
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60717156
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60072352
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.59579008
49* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57956944
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.57305337
51RACK7_27058665_Chip-Seq_MCF-7_Human1.55448931
52ELK1_19687146_ChIP-ChIP_HELA_Human1.54986264
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.54480981
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.49997399
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48519319
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47987430
57ZNF263_19887448_ChIP-Seq_K562_Human1.46456667
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46348550
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46054659
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45827051
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45098829
62* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44928862
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44343090
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44001325
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43742064
66GABP_19822575_ChIP-Seq_HepG2_Human1.42360511
67BRD4_25478319_ChIP-Seq_HGPS_Human1.41948136
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41537054
69* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41472038
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40529260
71AHR_22903824_ChIP-Seq_MCF-7_Human1.40177217
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.38087420
73VDR_24763502_ChIP-Seq_THP-1_Human1.37242208
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37139167
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36494877
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34279260
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.33981505
78VDR_21846776_ChIP-Seq_THP-1_Human1.31867962
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31832277
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31292147
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.31098131
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.30725929
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29317807
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.29244561
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.28545681
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27560932
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27276098
88MAF_26560356_Chip-Seq_TH1_Human1.27153802
89* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26628949
90GATA1_22025678_ChIP-Seq_K562_Human1.26278626
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26183819
92ELF5_23300383_ChIP-Seq_T47D_Human1.25886392
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25788629
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25213510
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25149794
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22940571
97TCF7_22412390_ChIP-Seq_EML_Mouse1.22333783
98XRN2_22483619_ChIP-Seq_HELA_Human1.21548368
99GATA4_25053715_ChIP-Seq_YYC3_Human1.21158005
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.19873019
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19697455
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18484864
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18032383
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17872464
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17668853
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16991375
107TP53_22127205_ChIP-Seq_IMR90_Human1.15069416
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14113375
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11491284
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11372129
111GATA6_25053715_ChIP-Seq_YYC3_Human1.10817104
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10198730
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09717773
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09367690
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09289918
116TBX20_22080862_ChIP-Seq_HEART_Mouse1.08803839
117TBX20_22328084_ChIP-Seq_HEART_Mouse1.08803839
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.08691284
119SCL_19346495_ChIP-Seq_HPC-7_Human1.08071276
120* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07896619
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07103034
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06872645
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06872645
124RUNX1_22412390_ChIP-Seq_EML_Mouse1.06185553
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06092450
126MYB_26560356_Chip-Seq_TH2_Human1.05980146
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05949375
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05946780
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05786274
130KDM5A_27292631_Chip-Seq_BREAST_Human1.04774886
131UTX_26944678_Chip-Seq_JUKART_Human1.02766818
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01328247
133SMAD_19615063_ChIP-ChIP_OVARY_Human1.01095096
134MYC_22102868_ChIP-Seq_BL_Human1.00514553
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.99955674
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.99406321
137* STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99099482
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98935479
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98166675
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97978187
141THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97823770
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97417019
143ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96309084
144CHD1_26751641_Chip-Seq_LNCaP_Human0.96069580
145KLF5_25053715_ChIP-Seq_YYC3_Human0.95904136
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.95792739
147RUNX_20019798_ChIP-Seq_JUKART_Human0.95338447
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95094404
149HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93916303
150SRF_21415370_ChIP-Seq_HL-1_Mouse0.93457217
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93342924
152E2F1_21310950_ChIP-Seq_MCF-7_Human0.93064261
153MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90359519
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88770923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.13801996
2MP0008438_abnormal_cutaneous_collagen3.69212536
3MP0003705_abnormal_hypodermis_morpholog3.43829184
4MP0005275_abnormal_skin_tensile3.27128027
5MP0006054_spinal_hemorrhage3.15455712
6MP0010352_gastrointestinal_tract_polyps3.05274115
7MP0003566_abnormal_cell_adhesion2.66490070
8MP0001879_abnormal_lymphatic_vessel2.58407746
9MP0010368_abnormal_lymphatic_system2.44386600
10MP0001958_emphysema2.42341388
11MP0004272_abnormal_basement_membrane2.42267891
12MP0003279_aneurysm2.19791958
13MP0009780_abnormal_chondrocyte_physiolo2.17689408
14MP0010234_abnormal_vibrissa_follicle2.15895031
15MP0002234_abnormal_pharynx_morphology2.12866541
16MP0004233_abnormal_muscle_weight1.95602640
17MP0002060_abnormal_skin_morphology1.94827866
18MP0005023_abnormal_wound_healing1.90652414
19MP0003941_abnormal_skin_development1.81264490
20MP0003300_gastrointestinal_ulcer1.76164864
21MP0003091_abnormal_cell_migration1.76095130
22MP0009384_cardiac_valve_regurgitation1.73597493
23MP0000733_abnormal_muscle_development1.71070749
24MP0005503_abnormal_tendon_morphology1.67524414
25MP0003806_abnormal_nucleotide_metabolis1.65591297
26MP0008875_abnormal_xenobiotic_pharmacok1.65339051
27MP0005623_abnormal_meninges_morphology1.56338624
28MP0000750_abnormal_muscle_regeneration1.52079862
29MP0002796_impaired_skin_barrier1.51683466
30MP0004264_abnormal_extraembryonic_tissu1.50465737
31MP0002877_abnormal_melanocyte_morpholog1.47012727
32MP0002396_abnormal_hematopoietic_system1.44567497
33MP0003828_pulmonary_edema1.41817221
34MP0000427_abnormal_hair_cycle1.40712733
35MP0000767_abnormal_smooth_muscle1.40246333
36MP0000566_synostosis1.37399784
37MP0000749_muscle_degeneration1.36922544
38MP0005257_abnormal_intraocular_pressure1.36689466
39MP0001542_abnormal_bone_strength1.34543330
40MP0003755_abnormal_palate_morphology1.33348645
41MP0003453_abnormal_keratinocyte_physiol1.33333723
42MP0009379_abnormal_foot_pigmentation1.32875516
43MP0002166_altered_tumor_susceptibility1.32732399
44MP0005501_abnormal_skin_physiology1.31475277
45MP0001243_abnormal_dermal_layer1.30370062
46MP0000343_altered_response_to1.29081592
47MP0010155_abnormal_intestine_physiology1.27969742
48MP0000490_abnormal_crypts_of1.26046267
49MP0000647_abnormal_sebaceous_gland1.25835430
50MP0000465_gastrointestinal_hemorrhage1.20089692
51MP0000858_altered_metastatic_potential1.18207237
52MP0004957_abnormal_blastocyst_morpholog1.15681275
53MP0004808_abnormal_hematopoietic_stem1.14409715
54MP0003724_increased_susceptibility_to1.14113830
55MP0000537_abnormal_urethra_morphology1.13792179
56MP0001545_abnormal_hematopoietic_system1.13687834
57MP0005397_hematopoietic_system_phenotyp1.13687834
58MP0002697_abnormal_eye_size1.12030714
59MP0001533_abnormal_skeleton_physiology1.11870122
60MP0003436_decreased_susceptibility_to1.11677500
61MP0005508_abnormal_skeleton_morphology1.11052907
62MP0003693_abnormal_embryo_hatching1.10275611
63MP0002006_tumorigenesis1.09514796
64MP0004947_skin_inflammation1.09478396
65MP0000627_abnormal_mammary_gland1.09127073
66MP0008004_abnormal_stomach_pH1.08992002
67MP0003950_abnormal_plasma_membrane1.08751011
68MP0005248_abnormal_Harderian_gland1.08418908
69MP0001216_abnormal_epidermal_layer1.08286523
70MP0003786_premature_aging1.06347549
71MP0000383_abnormal_hair_follicle1.05968290
72MP0008932_abnormal_embryonic_tissue1.05808501
73MP0003303_peritoneal_inflammation1.05754439
74MP0004087_abnormal_muscle_fiber1.04548835
75MP0010678_abnormal_skin_adnexa1.04544631
76MP0003315_abnormal_perineum_morphology1.01909664
77MP0000249_abnormal_blood_vessel1.01853737
78MP0001873_stomach_inflammation1.01639292
79MP0009053_abnormal_anal_canal0.99016675
80MP0000013_abnormal_adipose_tissue0.98965079
81MP0009278_abnormal_bone_marrow0.98509504
82MP0005164_abnormal_response_to0.98314096
83MP0005390_skeleton_phenotype0.96945208
84MP0003448_altered_tumor_morphology0.96925681
85MP0000462_abnormal_digestive_system0.96739673
86MP0001849_ear_inflammation0.96697523
87MP0002332_abnormal_exercise_endurance0.95213410
88MP0010630_abnormal_cardiac_muscle0.94309102
89MP0000358_abnormal_cell_content/0.93179209
90MP0003937_abnormal_limbs/digits/tail_de0.93096842
91MP0010771_integument_phenotype0.92689882
92MP0003186_abnormal_redox_activity0.92390220
93MP0002925_abnormal_cardiovascular_devel0.92030070
94MP0000751_myopathy0.91966674
95MP0000759_abnormal_skeletal_muscle0.91686939
96MP0005167_abnormal_blood-brain_barrier0.91658798
97MP0010030_abnormal_orbit_morphology0.90626577
98MP0005197_abnormal_uvea_morphology0.90310902
99MP0004883_abnormal_blood_vessel0.89878386
100MP0005084_abnormal_gallbladder_morpholo0.89781225
101MP0001614_abnormal_blood_vessel0.89365402
102MP0000377_abnormal_hair_follicle0.89150657
103MP0005367_renal/urinary_system_phenotyp0.89089788
104MP0000516_abnormal_urinary_system0.89089788
105MP0002405_respiratory_system_inflammati0.87745185
106MP0002295_abnormal_pulmonary_circulatio0.87099400
107MP0000467_abnormal_esophagus_morphology0.87047876
108MP0009785_altered_susceptibility_to0.86091194
109MP0008007_abnormal_cellular_replicative0.85218207
110MP0003045_fibrosis0.85124004
111MP0002128_abnormal_blood_circulation0.83791555
112MP0000762_abnormal_tongue_morphology0.82445416
113MP0002282_abnormal_trachea_morphology0.81618710
114MP0005076_abnormal_cell_differentiation0.80736573
115MP0002098_abnormal_vibrissa_morphology0.80199532
116MP0001299_abnormal_eye_distance/0.80006662
117MP0008789_abnormal_olfactory_epithelium0.79981961
118MP0001191_abnormal_skin_condition0.79739281
119MP0003935_abnormal_craniofacial_develop0.79382239
120MP0009931_abnormal_skin_appearance0.79363858
121MP0002233_abnormal_nose_morphology0.79327622
122MP0008058_abnormal_DNA_repair0.78824033
123MP0005409_darkened_coat_color0.78799616
124MP0001853_heart_inflammation0.78171788
125MP0002896_abnormal_bone_mineralization0.76864551
126MP0002084_abnormal_developmental_patter0.76486729
127MP0010094_abnormal_chromosome_stability0.76409574
128MP0002998_abnormal_bone_remodeling0.75405503
129MP0002111_abnormal_tail_morphology0.75088894
130MP0005193_abnormal_anterior_eye0.73770463
131MP0004197_abnormal_fetal_growth/weight/0.73277849
132MP0001666_abnormal_nutrient_absorption0.72953314
133MP0000003_abnormal_adipose_tissue0.72733057
134MP0001340_abnormal_eyelid_morphology0.72444010
135MP0000049_abnormal_middle_ear0.72098879
136MP0005083_abnormal_biliary_tract0.71150718
137MP0001286_abnormal_eye_development0.70624785
138MP0003385_abnormal_body_wall0.70465416
139MP0002113_abnormal_skeleton_development0.69524521
140MP0005165_increased_susceptibility_to0.69350517
141MP0003718_maternal_effect0.69278605
142MP0009250_abnormal_appendicular_skeleto0.69057955
143MP0003191_abnormal_cellular_cholesterol0.68996384
144MP0004782_abnormal_surfactant_physiolog0.68976908
145MP0005330_cardiomyopathy0.67949041
146MP0003077_abnormal_cell_cycle0.67444609
147MP0002177_abnormal_outer_ear0.66547921
148MP0000613_abnormal_salivary_gland0.64894232
149MP0002085_abnormal_embryonic_tissue0.64698671
150MP0004185_abnormal_adipocyte_glucose0.64008158
151MP0001672_abnormal_embryogenesis/_devel0.62917789
152MP0005380_embryogenesis_phenotype0.62917789
153MP0000350_abnormal_cell_proliferation0.62502100
154MP0000367_abnormal_coat/_hair0.62361570
155MP0002080_prenatal_lethality0.62192101
156MP0006138_congestive_heart_failure0.61172774
157MP0003984_embryonic_growth_retardation0.60572278
158MP0008260_abnormal_autophagy0.59303886
159MP0000678_abnormal_parathyroid_gland0.58803254

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.73584213
2Protrusio acetabuli (HP:0003179)4.72899467
3Abnormality of nail color (HP:0100643)4.46107926
4Atrophic scars (HP:0001075)4.40548318
5Muscle fiber inclusion bodies (HP:0100299)4.11131638
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.09070427
7Increased connective tissue (HP:0009025)3.90652189
8Nemaline bodies (HP:0003798)3.81337572
9Type 1 muscle fiber predominance (HP:0003803)3.74403609
10Popliteal pterygium (HP:0009756)3.71209436
11Distal arthrogryposis (HP:0005684)3.56119644
12Palmoplantar hyperkeratosis (HP:0000972)3.54639580
13Amniotic constriction ring (HP:0009775)3.54613584
14Abnormality of placental membranes (HP:0011409)3.54613584
15Palmar hyperkeratosis (HP:0010765)3.45297085
16Round ear (HP:0100830)3.38493099
17Aortic dissection (HP:0002647)3.32307391
18Fragile skin (HP:0001030)3.28142799
19Aortic aneurysm (HP:0004942)3.23767764
20Right ventricular cardiomyopathy (HP:0011663)3.23332730
21Calcaneovalgus deformity (HP:0001848)3.17165000
22Distal lower limb muscle weakness (HP:0009053)3.07762307
23Hypotrichosis (HP:0001006)3.04182567
24Ulnar deviation of the wrist (HP:0003049)3.00494767
25Cervical subluxation (HP:0003308)2.97223547
26Spinal rigidity (HP:0003306)2.96570600
27Cerebral aneurysm (HP:0004944)2.96397523
28Pili torti (HP:0003777)2.94905972
29Milia (HP:0001056)2.92975029
30Abnormality of the calcaneus (HP:0008364)2.88191897
31Onycholysis (HP:0001806)2.86385865
32Deformed tarsal bones (HP:0008119)2.83782908
33Hematochezia (HP:0002573)2.82102778
34Natal tooth (HP:0000695)2.80439084
35Peritonitis (HP:0002586)2.79588773
36Congenital ichthyosiform erythroderma (HP:0007431)2.79247851
37Oral leukoplakia (HP:0002745)2.76833439
38Sparse eyelashes (HP:0000653)2.74672140
39Osteolytic defects of the hand bones (HP:0009699)2.72148655
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.72148655
41Hyporeflexia of lower limbs (HP:0002600)2.71919779
42Difficulty climbing stairs (HP:0003551)2.70194959
43Muscle fiber splitting (HP:0003555)2.69555295
44Broad metatarsal (HP:0001783)2.67943325
45Shallow orbits (HP:0000586)2.66970316
46Myopathic facies (HP:0002058)2.66384740
47Dilatation of the ascending aorta (HP:0005111)2.61192799
48Mildly elevated creatine phosphokinase (HP:0008180)2.57443158
49Abnormal hair laboratory examination (HP:0003328)2.55800133
50Ankle contracture (HP:0006466)2.54024133
51Distal lower limb amyotrophy (HP:0008944)2.53472082
52Abnormality of skeletal muscle fiber size (HP:0012084)2.47155078
53Selective tooth agenesis (HP:0001592)2.44362671
54Advanced eruption of teeth (HP:0006288)2.40655598
55Erythroderma (HP:0001019)2.38583664
56Abnormalities of placenta or umbilical cord (HP:0001194)2.32732258
57Absent phalangeal crease (HP:0006109)2.31653723
58Lip pit (HP:0100267)2.30379170
59Facial diplegia (HP:0001349)2.29655638
60Fibular aplasia (HP:0002990)2.27998986
61Increased density of long bones (HP:0006392)2.25493867
62Ridged nail (HP:0001807)2.25355317
63Thin bony cortex (HP:0002753)2.25261767
64Short nail (HP:0001799)2.24985837
65Interstitial pulmonary disease (HP:0006530)2.23853694
66Scapular winging (HP:0003691)2.20027269
67Exercise-induced muscle cramps (HP:0003710)2.19716780
68Soft skin (HP:0000977)2.18170750
69Subacute progressive viral hepatitis (HP:0006572)2.16378199
70Limb-girdle muscle atrophy (HP:0003797)2.15315435
71Fatigable weakness (HP:0003473)2.13138840
72Abnormality of the neuromuscular junction (HP:0003398)2.13138840
73Wrist flexion contracture (HP:0001239)2.12756011
74Wormian bones (HP:0002645)2.11346288
75Entropion (HP:0000621)2.11131783
76Malignant hyperthermia (HP:0002047)2.08912720
77Fragile nails (HP:0001808)2.08325481
78Vertebral compression fractures (HP:0002953)2.08105162
79Alopecia of scalp (HP:0002293)2.07501333
80Squamous cell carcinoma (HP:0002860)2.07055531
81Vascular tortuosity (HP:0004948)2.06279812
82Corneal erosion (HP:0200020)2.05664654
83Increased variability in muscle fiber diameter (HP:0003557)2.05180587
84Broad face (HP:0000283)2.03336926
85Mitral valve prolapse (HP:0001634)2.02772288
86EMG: myopathic abnormalities (HP:0003458)2.01523273
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01444084
88Mitral regurgitation (HP:0001653)1.99900161
89Neck muscle weakness (HP:0000467)1.99579173
90Difficulty running (HP:0009046)1.98712887
91Hypoplasia of dental enamel (HP:0006297)1.97336552
92Plantar hyperkeratosis (HP:0007556)1.95907516
93Micronodular cirrhosis (HP:0001413)1.95385494
94Radial bowing (HP:0002986)1.94757957
95Frequent falls (HP:0002359)1.93218334
96Abnormality of the distal phalanges of the toes (HP:0010182)1.92648443
97Trismus (HP:0000211)1.92592106
98Curly hair (HP:0002212)1.92580781
99Woolly hair (HP:0002224)1.92378291
100Syringomyelia (HP:0003396)1.91541941
101Spinal cord lesions (HP:0100561)1.91541941
102Thrombocytosis (HP:0001894)1.90805342
103Rectal prolapse (HP:0002035)1.90305528
104Blue sclerae (HP:0000592)1.88815266
105Absent eyelashes (HP:0000561)1.88010359
106Reduced subcutaneous adipose tissue (HP:0003758)1.87866307
107Ulnar bowing (HP:0003031)1.87758963
108Hyperacusis (HP:0010780)1.87523075
109Elbow flexion contracture (HP:0002987)1.85695474
110Spondylolisthesis (HP:0003302)1.84749176
111Spontaneous hematomas (HP:0007420)1.84269201
112Nonimmune hydrops fetalis (HP:0001790)1.83738668
113Poikiloderma (HP:0001029)1.83508911
114Muscle stiffness (HP:0003552)1.83360223
115Thick nail (HP:0001805)1.83203508
116Abnormal finger flexion creases (HP:0006143)1.82814337
117Brittle hair (HP:0002299)1.82658946
118Erythema (HP:0010783)1.82396385
119Ectropion (HP:0000656)1.82334982
120Joint stiffness (HP:0001387)1.82047017
121Pustule (HP:0200039)1.78865641
122Pterygium (HP:0001059)1.78838112
123Elfin facies (HP:0004428)1.76758461
124Congenital, generalized hypertrichosis (HP:0004540)1.76632149
125Ureteral duplication (HP:0000073)1.76481923
126Weak cry (HP:0001612)1.76137313
127Arterial tortuosity (HP:0005116)1.73566294
128Bladder diverticulum (HP:0000015)1.70712696
129Hypoplastic labia majora (HP:0000059)1.70102951
130Focal segmental glomerulosclerosis (HP:0000097)1.69334450
131Palmoplantar keratoderma (HP:0000982)1.69105384
132Camptodactyly of toe (HP:0001836)1.69060403
133Persistence of primary teeth (HP:0006335)1.68980271
134Ventricular tachycardia (HP:0004756)1.68755566
135Nail dystrophy (HP:0008404)1.68656278
136Lower limb amyotrophy (HP:0007210)1.68175221
137Abnormality of the umbilical cord (HP:0010881)1.68090811
138Mesomelia (HP:0003027)1.67917928
139Aneurysm (HP:0002617)1.67325182
140Gastrointestinal dysmotility (HP:0002579)1.67129749
141Slender build (HP:0001533)1.66595859
142Abnormality of the acetabulum (HP:0003170)1.63856267
143Abnormality of the labia majora (HP:0012881)1.63847699
144Long foot (HP:0001833)1.62559530
145Rough bone trabeculation (HP:0100670)1.60304067
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60164715
147Abnormality of the preputium (HP:0100587)1.59386495
148Sparse scalp hair (HP:0002209)1.59321463
149Conjugated hyperbilirubinemia (HP:0002908)1.58749992
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58442477
151Microglossia (HP:0000171)1.58076544
152Tibial bowing (HP:0002982)1.55684756
153Spinal cord compression (HP:0002176)1.54827600
154Acanthosis nigricans (HP:0000956)1.53548502
155Asymmetry of the thorax (HP:0001555)1.53254018
156Cutaneous melanoma (HP:0012056)1.52971229
157Abnormality of glycolysis (HP:0004366)1.52834906
158Follicular hyperkeratosis (HP:0007502)1.52686168
159Glomerulosclerosis (HP:0000096)1.52633666
160Deviation of the thumb (HP:0009603)1.52433383
161Absent frontal sinuses (HP:0002688)1.51921878
162Delayed gross motor development (HP:0002194)1.51142355
163Abnormal blistering of the skin (HP:0008066)1.51028153
164Aplasia cutis congenita (HP:0001057)1.50163989
165Dry hair (HP:0011359)1.49924245
166Bowed forearm bones (HP:0003956)1.47842495
167Bowing of the arm (HP:0006488)1.47842495
168Aplasia of the musculature (HP:0100854)1.46933216
169Sensory axonal neuropathy (HP:0003390)1.46566239
170Amelogenesis imperfecta (HP:0000705)1.46556859
171Autoamputation (HP:0001218)1.46396321
172Hypoplasia of the uterus (HP:0000013)1.46262333
173Shoulder girdle muscle weakness (HP:0003547)1.44669279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.44108890
2PBK3.15879947
3TRIB32.87018070
4RIPK12.77769520
5TRPM72.64939114
6IRAK32.60496503
7ERBB42.54956682
8PIM22.51742476
9EPHA22.49257950
10MAP2K32.36719497
11KDR2.36186301
12ERN12.32417956
13MAP3K122.27054339
14MAPKAPK32.22257228
15TGFBR22.18549975
16EEF2K2.17999903
17MAP3K32.17247369
18LRRK22.15788049
19TESK12.12466732
20PKN22.12353707
21NEK12.05417200
22FLT31.96594323
23DDR21.85955889
24STK101.83600431
25TGFBR11.79862606
26INSRR1.76942035
27EPHB21.74151015
28TIE11.73621281
29EIF2AK11.70879380
30NME21.65086553
31DMPK1.60932290
32SIK11.58628177
33PTK61.56157019
34PIK3CG1.51475594
35LIMK11.51440198
36SRPK11.49476360
37ERBB31.49102065
38MST41.46307909
39RPS6KB21.44732540
40MUSK1.42682661
41PAK41.41509057
42PAK21.38746116
43FER1.36109904
44PDGFRA1.30869376
45STK391.29609092
46TSSK61.27249560
47TAOK21.25438322
48BCR1.25300509
49BUB11.24985892
50FRK1.21387437
51LATS11.19779533
52VRK21.19233538
53KIT1.17429583
54EPHB11.14380480
55PTK21.13978556
56PRKG21.13256739
57TRIM281.10803908
58PIK3CA1.10183438
59OBSCN1.09902328
60ILK1.08393572
61MOS1.08131912
62MAP3K111.05597970
63TEC1.04494427
64MYLK1.03809987
65MST1R1.03220383
66NEK91.00008912
67TAOK10.96056478
68SCYL20.94156695
69MAP3K100.93552474
70BRSK10.92358526
71STK38L0.91630958
72SMG10.91057923
73NUAK10.90725522
74RPS6KA40.90349563
75CDK60.86503478
76EIF2AK30.86222804
77LATS20.85880034
78ZAP700.85853921
79TBK10.85016348
80PRKCI0.84777633
81MAP2K20.84245745
82CASK0.82713753
83MAP3K90.82376002
84MAP2K70.80962514
85SIK30.77612139
86NTRK10.75870357
87CAMK2G0.75547045
88AURKB0.74555162
89MAP2K10.73613898
90BMX0.73437258
91MAP3K80.72602724
92MATK0.72144830
93MAPKAPK20.70749714
94WNK40.70097567
95ICK0.70086047
96AURKA0.69505407
97STK30.69392350
98ABL20.69257587
99PTK2B0.68971847
100CSK0.67354426
101STK380.66018309
102BRSK20.64559467
103CAMK2B0.64227844
104MAP3K70.64168805
105FGFR30.63651588
106PDGFRB0.62174377
107NEK60.60872750
108MAPKAPK50.58662926
109MAP3K140.56969837
110CSNK1A1L0.56951654
111EPHA30.56588642
112CSF1R0.56526965
113KSR10.55235026
114PIM10.54988337
115NLK0.54871410
116ITK0.54312344
117CDK90.51671004
118DYRK1B0.51141457
119CHEK20.50615697
120BCKDK0.50407631
121BTK0.50333551
122PRKCE0.50215241
123CAMK2D0.50093328
124CDK70.49630529
125CSNK1G30.48985264
126ARAF0.47826999
127CDK80.47355361
128AKT20.46942250
129MET0.45114286
130MELK0.44704379
131TTK0.42116762
132PLK10.40969806
133WEE10.40534272
134IRAK20.39475034
135MAP3K50.39051929
136JAK30.38235430
137ROCK10.36899089
138ABL10.36385420
139PDK20.36370545
140CSNK1G10.35741162
141MAP3K60.35604657
142MAP4K20.35481060
143TAF10.34350769
144RPS6KA20.34216005
145TESK20.33976522
146STK160.32807755
147PRKD10.32467616
148STK240.31567499
149EGFR0.31500801
150PAK10.31373838
151CHUK0.30937821
152RPS6KC10.29495242
153RPS6KL10.29495242
154LMTK20.28918635
155MTOR0.28689554
156NME10.28239456
157MAP3K20.27907103

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.62849367
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45294376
3Focal adhesion_Homo sapiens_hsa045102.36450846
4Leukocyte transendothelial migration_Homo sapiens_hsa046702.30363432
5Proteasome_Homo sapiens_hsa030502.27688861
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.16650479
7Adherens junction_Homo sapiens_hsa045202.12926433
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.11418755
9Small cell lung cancer_Homo sapiens_hsa052222.04951106
10Fructose and mannose metabolism_Homo sapiens_hsa000512.00777416
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99156322
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.98917124
13Pentose phosphate pathway_Homo sapiens_hsa000301.96178871
14Proteoglycans in cancer_Homo sapiens_hsa052051.95116774
15Selenocompound metabolism_Homo sapiens_hsa004501.89952199
16Bladder cancer_Homo sapiens_hsa052191.85369708
17Shigellosis_Homo sapiens_hsa051311.82988769
18Viral myocarditis_Homo sapiens_hsa054161.78538634
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78036920
20Amoebiasis_Homo sapiens_hsa051461.73664244
21Toxoplasmosis_Homo sapiens_hsa051451.72449454
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71065994
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70435774
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68883313
25Malaria_Homo sapiens_hsa051441.68813163
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68662748
27Leishmaniasis_Homo sapiens_hsa051401.64234965
28Thyroid cancer_Homo sapiens_hsa052161.58315750
29Vitamin B6 metabolism_Homo sapiens_hsa007501.54512035
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53811813
31Chronic myeloid leukemia_Homo sapiens_hsa052201.53316989
32Protein digestion and absorption_Homo sapiens_hsa049741.51678623
33Biosynthesis of amino acids_Homo sapiens_hsa012301.49355667
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48783885
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48245016
36p53 signaling pathway_Homo sapiens_hsa041151.45862257
37Platelet activation_Homo sapiens_hsa046111.42680696
38Steroid biosynthesis_Homo sapiens_hsa001001.39309692
39Salmonella infection_Homo sapiens_hsa051321.38794418
40Nucleotide excision repair_Homo sapiens_hsa034201.36165121
41Dilated cardiomyopathy_Homo sapiens_hsa054141.35762758
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35321578
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.33118352
44Renin-angiotensin system_Homo sapiens_hsa046141.31944100
45Apoptosis_Homo sapiens_hsa042101.31201876
46TNF signaling pathway_Homo sapiens_hsa046681.31097474
47Pertussis_Homo sapiens_hsa051331.30181477
48TGF-beta signaling pathway_Homo sapiens_hsa043501.30090324
49MicroRNAs in cancer_Homo sapiens_hsa052061.29720220
50Tight junction_Homo sapiens_hsa045301.28945571
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28891957
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26334120
53Ribosome_Homo sapiens_hsa030101.26255850
54Pyruvate metabolism_Homo sapiens_hsa006201.24775646
55RNA transport_Homo sapiens_hsa030131.24085775
56Carbon metabolism_Homo sapiens_hsa012001.23433218
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22529595
58Hematopoietic cell lineage_Homo sapiens_hsa046401.21107026
59Phenylalanine metabolism_Homo sapiens_hsa003601.20688631
60Legionellosis_Homo sapiens_hsa051341.19829247
61Folate biosynthesis_Homo sapiens_hsa007901.18912251
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18373922
63Hippo signaling pathway_Homo sapiens_hsa043901.16808608
64Chemical carcinogenesis_Homo sapiens_hsa052041.13657370
65Pyrimidine metabolism_Homo sapiens_hsa002401.12685677
66Fanconi anemia pathway_Homo sapiens_hsa034601.12545168
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10323117
68HIF-1 signaling pathway_Homo sapiens_hsa040661.09101053
69Base excision repair_Homo sapiens_hsa034101.08827427
70Pancreatic cancer_Homo sapiens_hsa052121.06309944
71Vibrio cholerae infection_Homo sapiens_hsa051101.06288765
72Acute myeloid leukemia_Homo sapiens_hsa052211.05875939
73Sulfur relay system_Homo sapiens_hsa041221.05217279
74PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04017530
75VEGF signaling pathway_Homo sapiens_hsa043701.00231705
76beta-Alanine metabolism_Homo sapiens_hsa004100.99666201
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98057861
78Osteoclast differentiation_Homo sapiens_hsa043800.97034342
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94650890
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94638709
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94319318
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.94009168
83Pathways in cancer_Homo sapiens_hsa052000.93726434
84Fatty acid elongation_Homo sapiens_hsa000620.93074481
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.92133235
86Rap1 signaling pathway_Homo sapiens_hsa040150.91691236
87RNA polymerase_Homo sapiens_hsa030200.91286051
88DNA replication_Homo sapiens_hsa030300.90068247
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89877659
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88665317
91Histidine metabolism_Homo sapiens_hsa003400.88465735
92Mismatch repair_Homo sapiens_hsa034300.87575721
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85890402
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85483273
95One carbon pool by folate_Homo sapiens_hsa006700.85307283
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84470933
97Hepatitis B_Homo sapiens_hsa051610.84470037
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83823098
99HTLV-I infection_Homo sapiens_hsa051660.83227128
100Caffeine metabolism_Homo sapiens_hsa002320.80699431
101Phagosome_Homo sapiens_hsa041450.79835372
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.79365065
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79073752
104Tuberculosis_Homo sapiens_hsa051520.78651383
105Arginine and proline metabolism_Homo sapiens_hsa003300.78316007
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.78209779
107Influenza A_Homo sapiens_hsa051640.77821084
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77054190
109Viral carcinogenesis_Homo sapiens_hsa052030.77043068
110Tyrosine metabolism_Homo sapiens_hsa003500.76715110
111Hepatitis C_Homo sapiens_hsa051600.74769989
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74515304
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74468291
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72540860
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71001370
116Colorectal cancer_Homo sapiens_hsa052100.70028676
117Ovarian steroidogenesis_Homo sapiens_hsa049130.69905354
118Protein export_Homo sapiens_hsa030600.69380710
119Basal transcription factors_Homo sapiens_hsa030220.69139527
120Non-homologous end-joining_Homo sapiens_hsa034500.69132977
121Prostate cancer_Homo sapiens_hsa052150.68588113
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.68129919
123Cell cycle_Homo sapiens_hsa041100.68001776
124Axon guidance_Homo sapiens_hsa043600.67886563
125Sphingolipid metabolism_Homo sapiens_hsa006000.66773324
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.66346962
127Endometrial cancer_Homo sapiens_hsa052130.65210474
128Measles_Homo sapiens_hsa051620.63964917
129N-Glycan biosynthesis_Homo sapiens_hsa005100.63471975
130Mineral absorption_Homo sapiens_hsa049780.63327632
131Spliceosome_Homo sapiens_hsa030400.61986570
132Notch signaling pathway_Homo sapiens_hsa043300.61788998
133Melanoma_Homo sapiens_hsa052180.60903551
134Metabolic pathways_Homo sapiens_hsa011000.60727123
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60516927
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.60495965
137Endocytosis_Homo sapiens_hsa041440.60313121
138Galactose metabolism_Homo sapiens_hsa000520.59726941
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58088647
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56806102
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.56637942
142Starch and sucrose metabolism_Homo sapiens_hsa005000.56502573
143Homologous recombination_Homo sapiens_hsa034400.55795308
144B cell receptor signaling pathway_Homo sapiens_hsa046620.54431251
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53854582
146Pancreatic secretion_Homo sapiens_hsa049720.53664626
147Insulin resistance_Homo sapiens_hsa049310.52518329
148Basal cell carcinoma_Homo sapiens_hsa052170.52159069
149FoxO signaling pathway_Homo sapiens_hsa040680.52105676
150Huntingtons disease_Homo sapiens_hsa050160.51469352
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51390299
152Fat digestion and absorption_Homo sapiens_hsa049750.49495938
153Renal cell carcinoma_Homo sapiens_hsa052110.46988957
154Retinol metabolism_Homo sapiens_hsa008300.46714973
155Glutathione metabolism_Homo sapiens_hsa004800.46342938
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44921339
157Oxidative phosphorylation_Homo sapiens_hsa001900.44447347
158Glioma_Homo sapiens_hsa052140.43304979
159Arginine biosynthesis_Homo sapiens_hsa002200.42582221
160Sulfur metabolism_Homo sapiens_hsa009200.42433069
161Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40384902
162Herpes simplex infection_Homo sapiens_hsa051680.39423061
163Circadian rhythm_Homo sapiens_hsa047100.38957879
164Non-small cell lung cancer_Homo sapiens_hsa052230.38835936
165Purine metabolism_Homo sapiens_hsa002300.38204388
166Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38135973
167Epstein-Barr virus infection_Homo sapiens_hsa051690.37016502
168AMPK signaling pathway_Homo sapiens_hsa041520.35891251
169mRNA surveillance pathway_Homo sapiens_hsa030150.34398220

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