TRGV7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.78446026
2cytidine deamination (GO:0009972)7.78446026
3cytidine metabolic process (GO:0046087)7.78446026
4pyrimidine ribonucleoside catabolic process (GO:0046133)6.91405808
5DNA deamination (GO:0045006)6.39790259
6positive regulation of natural killer cell mediated immunity (GO:0002717)6.31955585
7positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.17146311
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.06399805
9regulation of regulatory T cell differentiation (GO:0045589)6.00516544
10eosinophil chemotaxis (GO:0048245)5.90643217
11positive regulation of gamma-delta T cell activation (GO:0046645)5.75785314
12regulation of natural killer cell mediated immunity (GO:0002715)5.71679029
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.71679029
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.63777441
15positive regulation of T cell chemotaxis (GO:0010820)5.57050282
16regulation of T cell chemotaxis (GO:0010819)5.57050282
17regulation of lymphocyte chemotaxis (GO:1901623)5.56827549
18response to interleukin-15 (GO:0070672)5.53597411
19cellular response to interleukin-15 (GO:0071350)5.43653480
20monocyte chemotaxis (GO:0002548)5.42303840
21eosinophil migration (GO:0072677)5.33317317
22negative regulation of T cell apoptotic process (GO:0070233)5.00929742
23positive thymic T cell selection (GO:0045059)4.99686024
24positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.93293345
25negative regulation by host of viral transcription (GO:0043922)4.92359653
26activated T cell proliferation (GO:0050798)4.82824126
27positive regulation of interleukin-8 secretion (GO:2000484)4.80735515
28positive regulation of monocyte chemotaxis (GO:0090026)4.79815773
29regulation of chronic inflammatory response (GO:0002676)4.76737459
30regulation of T cell tolerance induction (GO:0002664)4.75045144
31regulation of activation of Janus kinase activity (GO:0010533)4.70223183
32macrophage chemotaxis (GO:0048246)4.64235990
33regulation of leukocyte mediated cytotoxicity (GO:0001910)4.61771857
34positive T cell selection (GO:0043368)4.56068560
35regulation of gamma-delta T cell differentiation (GO:0045586)4.51725919
36dendritic cell chemotaxis (GO:0002407)4.41394178
37positive regulation of tolerance induction (GO:0002645)4.38664574
38positive regulation of cell killing (GO:0031343)4.36189964
39positive regulation of lymphocyte migration (GO:2000403)4.31038051
40regulation of gamma-delta T cell activation (GO:0046643)4.23476678
41regulation of B cell receptor signaling pathway (GO:0050855)4.17911883
42regulation of cell killing (GO:0031341)4.16994942
43Arp2/3 complex-mediated actin nucleation (GO:0034314)4.13629993
44regulation of tolerance induction (GO:0002643)4.12303220
45positive regulation of T cell apoptotic process (GO:0070234)4.11194245
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.99430347
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.97451559
48negative regulation of cell killing (GO:0031342)3.97451559
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.93318289
50regulation of mononuclear cell migration (GO:0071675)3.91663178
51granulocyte activation (GO:0036230)3.89429340
52negative regulation of viral genome replication (GO:0045071)3.81092043
53dendritic cell migration (GO:0036336)3.79209922
54regulation of macrophage chemotaxis (GO:0010758)3.71894208
55regulation of chemokine-mediated signaling pathway (GO:0070099)3.71178031
56T cell migration (GO:0072678)3.69934357
57negative regulation of B cell proliferation (GO:0030889)3.68569664
58regulation of lymphocyte migration (GO:2000401)3.67121497
59membrane raft organization (GO:0031579)3.65415909
60positive regulation of T cell mediated cytotoxicity (GO:0001916)3.63737320
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63653723
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.62816878
63regulation of T cell apoptotic process (GO:0070232)3.62495715
64interferon-gamma production (GO:0032609)3.59459147
65antigen processing and presentation of endogenous antigen (GO:0019883)3.59283764
66lymphocyte chemotaxis (GO:0048247)3.57085571
67regulation of T cell mediated cytotoxicity (GO:0001914)3.55594362
68positive regulation of T cell migration (GO:2000406)3.55048985
69T cell costimulation (GO:0031295)3.54804865
70lymphocyte costimulation (GO:0031294)3.49875924
71actin nucleation (GO:0045010)3.46379337
72T cell selection (GO:0045058)3.45782643
73thymic T cell selection (GO:0045061)3.44730386
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.42772256
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42309136
76regulation of T cell migration (GO:2000404)3.41148347
77negative regulation of interleukin-12 production (GO:0032695)3.40119027
78positive regulation of translational initiation (GO:0045948)3.39464427
79cellular defense response (GO:0006968)3.37945439
80regulation of monocyte chemotaxis (GO:0090025)3.36562449
81antigen processing and presentation via MHC class Ib (GO:0002475)3.35835675
82positive regulation of lymphocyte apoptotic process (GO:0070230)3.35664732
83negative T cell selection (GO:0043383)3.34859732
84regulation of interleukin-8 secretion (GO:2000482)3.30406143
85neutrophil activation (GO:0042119)3.30283743
86negative regulation of lymphocyte apoptotic process (GO:0070229)3.28701310
87positive regulation of calcium-mediated signaling (GO:0050850)3.26667644
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26188322
89pyrimidine nucleoside catabolic process (GO:0046135)3.22040053
90positive regulation of leukocyte apoptotic process (GO:2000108)3.20989841
91positive regulation of lymphocyte mediated immunity (GO:0002708)3.18816684
92negative regulation of viral transcription (GO:0032897)3.17288739
93negative regulation of B cell activation (GO:0050869)3.11256066
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05869332
95negative regulation of T-helper cell differentiation (GO:0045623)3.05035289
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05035289
97negative thymic T cell selection (GO:0045060)2.99688745
98negative regulation of alpha-beta T cell activation (GO:0046636)2.98614677
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95843208
100negative regulation of T cell activation (GO:0050868)2.94266362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.05108237
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.68021184
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.31628342
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.15261826
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.30016214
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25919096
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68375809
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66588909
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.22644576
10MYB_26560356_Chip-Seq_TH2_Human3.09886709
11RUNX_20019798_ChIP-Seq_JUKART_Human3.06089782
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88249742
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81624065
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59999535
15GATA3_27048872_Chip-Seq_THYMUS_Human2.46072249
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.45996849
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43875782
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31534382
19MYB_26560356_Chip-Seq_TH1_Human2.17812869
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16559952
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14217183
22MAF_26560356_Chip-Seq_TH1_Human2.13322993
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99615823
24UTX_26944678_Chip-Seq_JUKART_Human1.99359318
25SPI1_23547873_ChIP-Seq_NB4_Human1.97311246
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96688697
27MAF_26560356_Chip-Seq_TH2_Human1.94010861
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88715073
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87635006
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76691318
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74402899
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68885859
33GATA3_26560356_Chip-Seq_TH2_Human1.68565504
34SPI1_23127762_ChIP-Seq_K562_Human1.64714531
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61417132
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.48587144
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44286156
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42241134
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40182520
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35067949
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32000996
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31203970
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.23838025
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22759390
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.18184403
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17329273
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13790228
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11877418
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06565400
50SCL_19346495_ChIP-Seq_HPC-7_Human1.05712814
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04812570
52GATA3_26560356_Chip-Seq_TH1_Human1.01338129
53VDR_24763502_ChIP-Seq_THP-1_Human1.00272910
54PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99752522
55VDR_24787735_ChIP-Seq_THP-1_Human0.96208286
56ELF1_20517297_ChIP-Seq_JURKAT_Human0.94514097
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92703095
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91822796
59GATA1_19941827_ChIP-Seq_MEL_Mouse0.87702960
60GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86259044
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85108798
62TAF2_19829295_ChIP-Seq_ESCs_Human0.85053923
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84030571
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83219900
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83134935
66HTT_18923047_ChIP-ChIP_STHdh_Human0.82324791
67STAT1_20625510_ChIP-Seq_HELA_Human0.82257475
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81342472
69PU_27001747_Chip-Seq_BMDM_Mouse0.78360344
70SMRT_27268052_Chip-Seq_Bcells_Human0.76677096
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75875888
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75319702
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74611578
74TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74577639
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.73645991
76CIITA_25753668_ChIP-Seq_RAJI_Human0.72575137
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71750261
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71405860
79P300_27268052_Chip-Seq_Bcells_Human0.71078554
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70736464
81BCL6_27268052_Chip-Seq_Bcells_Human0.70470457
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.69999342
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69602974
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69262324
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.68820005
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68702747
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.68597070
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68254590
89SPI1_20517297_ChIP-Seq_HL60_Human0.67637990
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.67399314
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.67047400
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66942482
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66156095
94MYC_22102868_ChIP-Seq_BL_Human0.65702753
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.64971151
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64628305
97VDR_21846776_ChIP-Seq_THP-1_Human0.63296244
98VDR_23849224_ChIP-Seq_CD4+_Human0.62872303
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.62409481
100BCOR_27268052_Chip-Seq_Bcells_Human0.60325088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.84896554
2MP0006082_CNS_inflammation4.12907308
3MP0003763_abnormal_thymus_physiology3.55872083
4MP0001835_abnormal_antigen_presentation3.52431199
5MP0009785_altered_susceptibility_to3.38441751
6MP0005000_abnormal_immune_tolerance3.16666073
7MP0001800_abnormal_humoral_immune3.08804194
8MP0009333_abnormal_splenocyte_physiolog3.05283723
9MP0002148_abnormal_hypersensitivity_rea2.97101554
10MP0002723_abnormal_immune_serum2.89643390
11MP0005025_abnormal_response_to2.82465061
12MP0001790_abnormal_immune_system2.82123810
13MP0005387_immune_system_phenotype2.82123810
14MP0002420_abnormal_adaptive_immunity2.65591803
15MP0001819_abnormal_immune_cell2.60498761
16MP0002452_abnormal_antigen_presenting2.44166731
17MP0002419_abnormal_innate_immunity2.39910396
18MP0002405_respiratory_system_inflammati2.36304775
19MP0000685_abnormal_immune_system2.29273883
20MP0010155_abnormal_intestine_physiology2.27556412
21MP0003436_decreased_susceptibility_to2.23239147
22MP0003866_abnormal_defecation2.22100026
23MP0003724_increased_susceptibility_to2.22078588
24MP0002398_abnormal_bone_marrow2.20880534
25MP0001873_stomach_inflammation2.16721903
26MP0005464_abnormal_platelet_physiology2.15409373
27MP0000716_abnormal_immune_system2.10632427
28MP0001845_abnormal_inflammatory_respons1.95953436
29MP0000569_abnormal_digit_pigmentation1.91605504
30MP0005310_abnormal_salivary_gland1.90551778
31MP0000689_abnormal_spleen_morphology1.90142285
32MP0002722_abnormal_immune_system1.83935573
33MP0003448_altered_tumor_morphology1.79079158
34MP0002429_abnormal_blood_cell1.67737270
35MP0000703_abnormal_thymus_morphology1.66803372
36MP0001853_heart_inflammation1.57011015
37MP0002933_joint_inflammation1.56440251
38MP0002396_abnormal_hematopoietic_system1.52889569
39MP0004947_skin_inflammation1.51231627
40MP0008469_abnormal_protein_level1.44291600
41MP0003075_altered_response_to1.43619941
42MP0009764_decreased_sensitivity_to1.37784826
43MP0002877_abnormal_melanocyte_morpholog1.37134094
44MP0004381_abnormal_hair_follicle1.34122209
45MP0003172_abnormal_lysosome_physiology1.32615324
46MP0003045_fibrosis1.32459028
47MP0003878_abnormal_ear_physiology1.29555509
48MP0005377_hearing/vestibular/ear_phenot1.29555509
49MP0000858_altered_metastatic_potential1.28884372
50MP0002006_tumorigenesis1.27778424
51MP0002163_abnormal_gland_morphology1.26057448
52MP0002138_abnormal_hepatobiliary_system1.19234857
53MP0005174_abnormal_tail_pigmentation1.18524252
54MP0002166_altered_tumor_susceptibility1.14802047
55MP0009763_increased_sensitivity_to1.14126656
56MP0000343_altered_response_to1.07169687
57MP0001533_abnormal_skeleton_physiology1.07138180
58MP0002998_abnormal_bone_remodeling1.05569936
59MP0003300_gastrointestinal_ulcer1.05047892
60MP0004145_abnormal_muscle_electrophysio1.02389396
61MP0000015_abnormal_ear_pigmentation1.01396979
62MP0010307_abnormal_tumor_latency1.01380213
63MP0003303_peritoneal_inflammation1.01309106
64MP0005075_abnormal_melanosome_morpholog0.93900122
65MP0003183_abnormal_peptide_metabolism0.93539751
66MP0000920_abnormal_myelination0.90679592
67MP0003786_premature_aging0.88546222
68MP0005166_decreased_susceptibility_to0.85051622
69MP0002277_abnormal_respiratory_mucosa0.82866838
70MP0009765_abnormal_xenobiotic_induced0.82326997
71MP0008873_increased_physiological_sensi0.74516089
72MP0005379_endocrine/exocrine_gland_phen0.74448346
73MP0001661_extended_life_span0.69676153
74MP0001986_abnormal_taste_sensitivity0.66695690
75MP0003646_muscle_fatigue0.64745403
76MP0000249_abnormal_blood_vessel0.64054553
77MP0001188_hyperpigmentation0.63924556
78MP0002019_abnormal_tumor_incidence0.62823687
79MP0006035_abnormal_mitochondrial_morpho0.61524694
80MP0002693_abnormal_pancreas_physiology0.61142774
81MP0004883_abnormal_blood_vessel0.60959242
82MP0005083_abnormal_biliary_tract0.59001992
83MP0003191_abnormal_cellular_cholesterol0.58395437
84MP0001905_abnormal_dopamine_level0.58325500
85MP0005058_abnormal_lysosome_morphology0.55241045
86MP0004130_abnormal_muscle_cell0.52953909
87MP0002136_abnormal_kidney_physiology0.52885996
88MP0005319_abnormal_enzyme/_coenzyme0.50672812
89MP0003011_delayed_dark_adaptation0.49797045
90MP0005165_increased_susceptibility_to0.49561970
91MP0004808_abnormal_hematopoietic_stem0.47955448
92MP0004185_abnormal_adipocyte_glucose0.43675678
93MP0008004_abnormal_stomach_pH0.43652391
94MP0000465_gastrointestinal_hemorrhage0.43121535
95MP0003690_abnormal_glial_cell0.42942831
96MP0005167_abnormal_blood-brain_barrier0.42230551
97MP0004134_abnormal_chest_morphology0.41762156
98MP0003795_abnormal_bone_structure0.41244376
99MP0001765_abnormal_ion_homeostasis0.41217953
100MP0000609_abnormal_liver_physiology0.41217123

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.08060022
2Abnormality of T cell number (HP:0011839)7.01078332
3Abnormal delayed hypersensitivity skin test (HP:0002963)5.63516784
4Abnormality of T cells (HP:0002843)4.70839201
5Optic neuritis (HP:0100653)4.65794793
6Retrobulbar optic neuritis (HP:0100654)4.65794793
7Myositis (HP:0100614)4.56778997
8Hypoproteinemia (HP:0003075)4.43657717
9Orchitis (HP:0100796)4.24250371
10Meningitis (HP:0001287)4.20977276
11Encephalitis (HP:0002383)4.14121368
12Recurrent cutaneous fungal infections (HP:0011370)4.11680622
13Chronic mucocutaneous candidiasis (HP:0002728)4.11680622
14IgG deficiency (HP:0004315)4.11012483
15Increased IgM level (HP:0003496)4.09958846
16Hemoptysis (HP:0002105)4.08420312
17Autoimmune hemolytic anemia (HP:0001890)4.06863449
18Recurrent bacterial skin infections (HP:0005406)3.73832116
19Recurrent abscess formation (HP:0002722)3.71569472
20Abnormality of eosinophils (HP:0001879)3.70991126
21Obstructive lung disease (HP:0006536)3.68970088
22Chronic obstructive pulmonary disease (HP:0006510)3.68970088
23Pulmonary infiltrates (HP:0002113)3.67957584
24Severe combined immunodeficiency (HP:0004430)3.66556698
25Abnormality of macrophages (HP:0004311)3.66488781
26Gangrene (HP:0100758)3.64160479
27Vasculitis (HP:0002633)3.61608816
28Recurrent fungal infections (HP:0002841)3.45863686
29Autoimmune thrombocytopenia (HP:0001973)3.44953919
30Recurrent bronchitis (HP:0002837)3.42429280
31Keratoconjunctivitis sicca (HP:0001097)3.35381625
32Panhypogammaglobulinemia (HP:0003139)3.34904594
33Chest pain (HP:0100749)3.33649274
34Abnormality of the prostate (HP:0008775)3.31203372
35Leukocytosis (HP:0001974)3.30454183
36Recurrent skin infections (HP:0001581)3.27594540
37Pulmonary embolism (HP:0002204)3.24115516
38Chronic diarrhea (HP:0002028)3.23521654
39Eosinophilia (HP:0001880)3.21828672
40Hemiplegia (HP:0002301)3.18674418
41Recurrent viral infections (HP:0004429)3.15746444
42Pustule (HP:0200039)3.10278805
43Keratoconjunctivitis (HP:0001096)3.08077748
44Stomatitis (HP:0010280)3.05811953
45Thyroiditis (HP:0100646)3.03459630
46Hypoplasia of the thymus (HP:0000778)3.03438208
47Gastrointestinal infarctions (HP:0005244)3.01923132
48Combined immunodeficiency (HP:0005387)2.97749216
49Spontaneous hematomas (HP:0007420)2.95748984
50Abnormality of T cell physiology (HP:0011840)2.93698217
513-Methylglutaconic aciduria (HP:0003535)2.93654099
52Granulocytopenia (HP:0001913)2.93184252
53Elevated erythrocyte sedimentation rate (HP:0003565)2.88852420
54Abnormality of the pleura (HP:0002103)2.84947647
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.79938269
56Joint swelling (HP:0001386)2.74418888
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74019903
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74019903
59Lymphopenia (HP:0001888)2.71209822
60Mediastinal lymphadenopathy (HP:0100721)2.70196326
61Agammaglobulinemia (HP:0004432)2.69794355
62Abnormal albumin level (HP:0012116)2.58937351
63Hypoalbuminemia (HP:0003073)2.58937351
64Arterial thrombosis (HP:0004420)2.56579233
65Amaurosis fugax (HP:0100576)2.49869562
66Ureteral stenosis (HP:0000071)2.47542813
67Epistaxis (HP:0000421)2.38756450
68Polyneuropathy (HP:0001271)2.37874138
69Eczematoid dermatitis (HP:0000976)2.37295357
70Abnormality of the pericardium (HP:0001697)2.37292860
71Zonular cataract (HP:0010920)2.33848537
72Glomerulopathy (HP:0100820)2.31844489
73Thrombophlebitis (HP:0004418)2.31013146
74Anorexia (HP:0002039)2.29620042
75Ureteral obstruction (HP:0006000)2.28776968
76Hematochezia (HP:0002573)2.17789760
77Lymphoma (HP:0002665)2.09131236
78Bronchitis (HP:0012387)2.03518582
79Recurrent otitis media (HP:0000403)2.02681388
80Acute hepatic failure (HP:0006554)2.00628530
81Stomach cancer (HP:0012126)2.00353824
82Gingival bleeding (HP:0000225)1.97887859
83Abnormality of liposaccharide metabolism (HP:0010968)1.97797231
84Abnormality of glycosphingolipid metabolism (HP:0004343)1.97797231
85Abnormality of glycolipid metabolism (HP:0010969)1.97797231
86Recurrent gram-negative bacterial infections (HP:0005420)1.95689431
87Hypergammaglobulinemia (HP:0010702)1.94483326
88Keratitis (HP:0000491)1.94007324
89Abnormality of male internal genitalia (HP:0000022)1.92773988
90Global brain atrophy (HP:0002283)1.90736904
91Pulmonary fibrosis (HP:0002206)1.88979988
92Urticaria (HP:0001025)1.88341064
93Gingivitis (HP:0000230)1.86824324
94Increased serum ferritin (HP:0003281)1.86639589
95Abnormal biliary tract physiology (HP:0012439)1.86314919
96Bile duct proliferation (HP:0001408)1.86314919
97Increased CSF protein (HP:0002922)1.83580948
98Tetraplegia (HP:0002445)1.82602102
99Cerebral ischemia (HP:0002637)1.82005253
100Purpura (HP:0000979)1.81638137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.83227009
2KDR3.33681072
3MAP4K13.11609590
4FES3.05428002
5GRK72.79070863
6RIPK42.50677411
7TRIM282.46155468
8JAK32.39595113
9ITK2.32512485
10CSK2.32450201
11TAOK32.01821999
12ZAP702.01142347
13PIK3CG1.96458774
14SYK1.95163271
15ADRBK21.94586968
16TGFBR21.87120328
17ZAK1.75931109
18LCK1.63447728
19BUB11.52885688
20BLK1.49890122
21IKBKE1.49641560
22MST41.46873917
23BTK1.44036223
24PRKCQ1.43433839
25JAK11.42633757
26MAP3K121.42289597
27TBK11.34639008
28LYN1.33844525
29BCKDK1.31192432
30MAP3K141.23893316
31TYRO31.19928149
32CSF1R1.18628374
33TEC1.17828493
34TESK21.16761785
35JAK21.12795417
36IRAK41.12450320
37PIK3CA0.97911640
38STK100.97569419
39TYK20.91537031
40FYN0.84564260
41MAPKAPK30.83999715
42IKBKB0.81136579
43MAP3K50.80049279
44DAPK10.79059956
45TNK20.77208539
46MAP2K60.77137868
47MELK0.77095165
48MYLK0.76912844
49FGR0.76540150
50PDK10.75673406
51STK160.73088670
52GRK60.69679498
53HCK0.66157230
54IRAK30.64733134
55BMPR20.63036473
56PIM10.61256539
57BCR0.61196228
58MATK0.57845600
59PDGFRB0.56427183
60FRK0.55342227
61IGF1R0.50101251
62MARK30.47893949
63KIT0.47760512
64NEK90.47583349
65MAPKAPK20.46296250
66MAPK70.42461559
67EIF2AK20.41557403
68NUAK10.39035455
69PDPK10.37985799
70INSR0.36466529
71ERN10.32749946
72ACVR1B0.32692099
73ADRBK10.31937852
74EPHB10.31852413
75HIPK20.28342003
76MOS0.26852782
77WNK40.26803828
78SIK30.26251982
79ABL10.25656272
80GRK50.25320386
81CAMKK20.23847815
82CLK10.22257939
83CHUK0.21239884
84GRK10.21076212
85MAP2K30.20991465
86MAPK30.19486399
87MAP3K30.18913099
88ROCK10.17638983
89MAP3K130.15526017
90MAPK110.14942944
91PRKCD0.14897600
92MAPK120.14829435
93LRRK20.14610789
94PRKCH0.14372836
95CDK60.13577870
96PRKCA0.12861539
97RET0.12386033
98IRAK10.11579471
99TIE10.10431359
100PAK10.08823784

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.85614889
2Graft-versus-host disease_Homo sapiens_hsa053324.32949760
3Autoimmune thyroid disease_Homo sapiens_hsa053203.97551598
4Allograft rejection_Homo sapiens_hsa053303.68146346
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.35138290
6Antigen processing and presentation_Homo sapiens_hsa046123.28297254
7Rheumatoid arthritis_Homo sapiens_hsa053233.10522795
8Type I diabetes mellitus_Homo sapiens_hsa049402.86872627
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.83920237
10Hematopoietic cell lineage_Homo sapiens_hsa046402.79582412
11T cell receptor signaling pathway_Homo sapiens_hsa046602.70775934
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.41033875
13Measles_Homo sapiens_hsa051622.22435489
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20047370
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.11598110
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.08109989
17Salmonella infection_Homo sapiens_hsa051322.01806853
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.90050193
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88554279
20Chemokine signaling pathway_Homo sapiens_hsa040621.84538245
21Viral myocarditis_Homo sapiens_hsa054161.83412724
22Staphylococcus aureus infection_Homo sapiens_hsa051501.80186744
23Leishmaniasis_Homo sapiens_hsa051401.72510954
24Osteoclast differentiation_Homo sapiens_hsa043801.72509485
25Proteasome_Homo sapiens_hsa030501.59919464
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.54898163
27Asthma_Homo sapiens_hsa053101.52545798
28Malaria_Homo sapiens_hsa051441.46377179
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34514515
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27790588
31TNF signaling pathway_Homo sapiens_hsa046681.25612964
32Herpes simplex infection_Homo sapiens_hsa051681.20265609
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19414931
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.17387301
35Influenza A_Homo sapiens_hsa051641.11644362
36Tuberculosis_Homo sapiens_hsa051521.03731120
37Apoptosis_Homo sapiens_hsa042100.96103578
38Shigellosis_Homo sapiens_hsa051310.94885494
39Legionellosis_Homo sapiens_hsa051340.90552192
40Epstein-Barr virus infection_Homo sapiens_hsa051690.86752670
41B cell receptor signaling pathway_Homo sapiens_hsa046620.85041074
42Prion diseases_Homo sapiens_hsa050200.84481394
43HTLV-I infection_Homo sapiens_hsa051660.83571766
44Phagosome_Homo sapiens_hsa041450.78095036
45Toxoplasmosis_Homo sapiens_hsa051450.71836344
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67566459
47African trypanosomiasis_Homo sapiens_hsa051430.65886095
48Pertussis_Homo sapiens_hsa051330.65665389
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61063209
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60783256
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58238325
52Lysosome_Homo sapiens_hsa041420.57377971
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54396286
54Platelet activation_Homo sapiens_hsa046110.50031335
55Endocytosis_Homo sapiens_hsa041440.48630980
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45737004
57Hepatitis B_Homo sapiens_hsa051610.41385767
58Systemic lupus erythematosus_Homo sapiens_hsa053220.40854276
59Linoleic acid metabolism_Homo sapiens_hsa005910.36424421
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36129779
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.36093619
62Viral carcinogenesis_Homo sapiens_hsa052030.35695304
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.34092148
64Collecting duct acid secretion_Homo sapiens_hsa049660.33971229
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32827245
66Oxidative phosphorylation_Homo sapiens_hsa001900.32268149
67Non-small cell lung cancer_Homo sapiens_hsa052230.31587040
68Acute myeloid leukemia_Homo sapiens_hsa052210.28146916
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.25658710
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25373257
71Parkinsons disease_Homo sapiens_hsa050120.24784321
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24379060
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24018918
74Hepatitis C_Homo sapiens_hsa051600.21114072
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.18605018
76RNA polymerase_Homo sapiens_hsa030200.17110361
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.16070805
78Caffeine metabolism_Homo sapiens_hsa002320.15656539
79VEGF signaling pathway_Homo sapiens_hsa043700.15160779
80Pancreatic cancer_Homo sapiens_hsa052120.14977109
81Amoebiasis_Homo sapiens_hsa051460.10178914
82Ether lipid metabolism_Homo sapiens_hsa005650.09354872
83Chronic myeloid leukemia_Homo sapiens_hsa052200.07431160
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06468118
85Type II diabetes mellitus_Homo sapiens_hsa049300.05415659
86N-Glycan biosynthesis_Homo sapiens_hsa005100.04965046
87Regulation of autophagy_Homo sapiens_hsa041400.04118160
88Ras signaling pathway_Homo sapiens_hsa040140.04108072
89Alzheimers disease_Homo sapiens_hsa050100.02286231
90Prolactin signaling pathway_Homo sapiens_hsa049170.00703455
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00663421
92Insulin resistance_Homo sapiens_hsa049310.00581203
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0632543
94Complement and coagulation cascades_Homo sapiens_hsa04610-0.0629526
95MAPK signaling pathway_Homo sapiens_hsa04010-0.0490082
96Peroxisome_Homo sapiens_hsa04146-0.0485470
97Neurotrophin signaling pathway_Homo sapiens_hsa04722-0.0327712
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0228572
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0130666
100Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0003659

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