TRGV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.77764939
2cytidine deamination (GO:0009972)7.77764939
3cytidine metabolic process (GO:0046087)7.77764939
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.28889219
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.83486065
6cellular response to interleukin-15 (GO:0071350)6.71122288
7DNA deamination (GO:0045006)6.63922023
8negative regulation of T cell apoptotic process (GO:0070233)6.25114068
9response to interleukin-15 (GO:0070672)6.17700924
10regulation of regulatory T cell differentiation (GO:0045589)5.59014400
11positive regulation of T cell chemotaxis (GO:0010820)5.42743142
12regulation of T cell chemotaxis (GO:0010819)5.42743142
13positive regulation of gamma-delta T cell activation (GO:0046645)5.37952881
14positive regulation of natural killer cell mediated immunity (GO:0002717)5.34290019
15positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.29967429
16eosinophil chemotaxis (GO:0048245)5.24476901
17negative regulation by host of viral transcription (GO:0043922)5.02529976
18regulation of gamma-delta T cell differentiation (GO:0045586)4.90564935
19regulation of lymphocyte chemotaxis (GO:1901623)4.84265789
20positive T cell selection (GO:0043368)4.80146632
21regulation of natural killer cell mediated immunity (GO:0002715)4.78800616
22regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.78800616
23eosinophil migration (GO:0072677)4.72468282
24positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.71953488
25positive thymic T cell selection (GO:0045059)4.67032246
26regulation of activation of Janus kinase activity (GO:0010533)4.58571831
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56893003
28regulation of leukocyte mediated cytotoxicity (GO:0001910)4.53015378
29regulation of chronic inflammatory response (GO:0002676)4.42200947
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35493786
31regulation of T cell apoptotic process (GO:0070232)4.33546469
32activated T cell proliferation (GO:0050798)4.30837268
33regulation of gamma-delta T cell activation (GO:0046643)4.26443368
34positive regulation of cell killing (GO:0031343)4.19344335
35monocyte chemotaxis (GO:0002548)4.12235003
36regulation of cell killing (GO:0031341)4.08748299
37regulation of T cell mediated cytotoxicity (GO:0001914)4.00311544
38positive regulation of lymphocyte migration (GO:2000403)4.00295110
39cellular defense response (GO:0006968)3.98789861
40mast cell activation (GO:0045576)3.94829586
41mast cell degranulation (GO:0043303)3.93366368
42mast cell activation involved in immune response (GO:0002279)3.93366368
43negative T cell selection (GO:0043383)3.93337649
44regulation of B cell receptor signaling pathway (GO:0050855)3.92361761
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.90892414
46negative regulation of lymphocyte apoptotic process (GO:0070229)3.89499803
47negative regulation of viral genome replication (GO:0045071)3.82275861
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.81367165
49positive regulation of T cell cytokine production (GO:0002726)3.77156694
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74291784
51T cell selection (GO:0045058)3.73592443
52thymic T cell selection (GO:0045061)3.72198070
53interferon-gamma production (GO:0032609)3.69932054
54regulation of interleukin-2 biosynthetic process (GO:0045076)3.67490519
55negative regulation of thymocyte apoptotic process (GO:0070244)3.66543305
56dendritic cell chemotaxis (GO:0002407)3.65852098
57lymph node development (GO:0048535)3.64401618
58positive regulation of monocyte chemotaxis (GO:0090026)3.62633849
59T cell migration (GO:0072678)3.62620611
60positive regulation of calcium-mediated signaling (GO:0050850)3.61055670
61positive regulation of T cell migration (GO:2000406)3.60733386
62antigen processing and presentation of endogenous antigen (GO:0019883)3.58767460
63regulation of chemokine-mediated signaling pathway (GO:0070099)3.56148408
64regulation of T cell migration (GO:2000404)3.56122623
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54573594
66negative regulation of cell killing (GO:0031342)3.54255382
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54255382
68negative thymic T cell selection (GO:0045060)3.53490022
69macrophage chemotaxis (GO:0048246)3.51272088
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48349311
71regulation of T cell tolerance induction (GO:0002664)3.46207663
72regulation of B cell differentiation (GO:0045577)3.44015054
73positive regulation of B cell differentiation (GO:0045579)3.42436659
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39040197
75positive regulation of tolerance induction (GO:0002645)3.38676452
76regulation of lymphocyte migration (GO:2000401)3.38160530
77positive regulation of T cell apoptotic process (GO:0070234)3.36750452
78positive regulation of alpha-beta T cell proliferation (GO:0046641)3.36309316
79positive regulation of defense response to virus by host (GO:0002230)3.34577281
80NIK/NF-kappaB signaling (GO:0038061)3.28988136
81T cell costimulation (GO:0031295)3.25971791
82regulation of alpha-beta T cell proliferation (GO:0046640)3.25091059
83negative regulation of T cell mediated immunity (GO:0002710)3.22908230
84lymphocyte costimulation (GO:0031294)3.21584763
85regulation of macrophage chemotaxis (GO:0010758)3.20700557
86positive regulation of granulocyte differentiation (GO:0030854)3.20422693
87pyrimidine nucleoside catabolic process (GO:0046135)3.20416008
88positive regulation of interleukin-8 secretion (GO:2000484)3.20205159
89actin nucleation (GO:0045010)3.19001120
90regulation of interleukin-12 biosynthetic process (GO:0045075)3.18212931
91T cell receptor signaling pathway (GO:0050852)3.17835092
92positive regulation of interleukin-4 production (GO:0032753)3.16682341
93regulation of mononuclear cell migration (GO:0071675)3.15508065
94dendritic cell migration (GO:0036336)3.15491308
95modulation by host of symbiont transcription (GO:0052472)3.14180553
96modulation by host of viral transcription (GO:0043921)3.14180553
97programmed necrotic cell death (GO:0097300)3.12881550
98necroptotic process (GO:0070266)3.11527460
99regulation of tolerance induction (GO:0002643)3.10962203
100positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.09225380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.95139803
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.82522027
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.66558386
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.23501678
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.19774944
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.18571516
7IRF8_22096565_ChIP-ChIP_GC-B_Human5.06023994
8RUNX_20019798_ChIP-Seq_JUKART_Human3.52766069
9MYB_26560356_Chip-Seq_TH2_Human3.38532315
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27926658
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20447400
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.10635317
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86363952
14GATA3_27048872_Chip-Seq_THYMUS_Human2.78780576
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54236480
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.43983130
17MYB_26560356_Chip-Seq_TH1_Human2.25028929
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13289740
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11273661
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09479405
21UTX_26944678_Chip-Seq_JUKART_Human2.09343402
22GATA3_26560356_Chip-Seq_TH2_Human2.03396987
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97475781
24MAF_26560356_Chip-Seq_TH1_Human1.95841714
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84217639
26MAF_26560356_Chip-Seq_TH2_Human1.83618896
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78382392
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.75969920
29VDR_22108803_ChIP-Seq_LS180_Human1.70303585
30SPI1_23547873_ChIP-Seq_NB4_Human1.69497043
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65363167
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64355340
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50728016
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46068947
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40284350
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34563299
37VDR_23849224_ChIP-Seq_CD4+_Human1.32167830
38SPI1_23127762_ChIP-Seq_K562_Human1.29060178
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28514818
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22807417
41FOXP3_21729870_ChIP-Seq_TREG_Human1.18308500
42AR_21572438_ChIP-Seq_LNCaP_Human1.16278492
43GATA3_26560356_Chip-Seq_TH1_Human1.13955567
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13887541
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13855396
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12689341
47IGF1R_20145208_ChIP-Seq_DFB_Human1.10461525
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.10120512
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08319029
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05783719
51GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00020395
52CIITA_25753668_ChIP-Seq_RAJI_Human0.99541040
53GABP_17652178_ChIP-ChIP_JURKAT_Human0.97009623
54PRDM14_20953172_ChIP-Seq_ESCs_Human0.96877853
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96353017
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96265043
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93224845
58PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92299539
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92136710
60VDR_24787735_ChIP-Seq_THP-1_Human0.92129609
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91613482
62EST1_17652178_ChIP-ChIP_JURKAT_Human0.91448461
63SCL_19346495_ChIP-Seq_HPC-7_Human0.90521719
64VDR_24763502_ChIP-Seq_THP-1_Human0.89377547
65HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87711610
66RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87642739
67TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87274542
68EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85300700
69FOXH1_21741376_ChIP-Seq_EPCs_Human0.85091559
70NANOG_20526341_ChIP-Seq_ESCs_Human0.84163944
71RUNX1_22412390_ChIP-Seq_EML_Mouse0.83129233
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82343380
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81848950
74PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81476454
75GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78944591
76SMAD_19615063_ChIP-ChIP_OVARY_Human0.78790324
77HTT_18923047_ChIP-ChIP_STHdh_Human0.78390592
78ZNF274_21170338_ChIP-Seq_K562_Hela0.77803915
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76339917
80BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76152700
81TAF2_19829295_ChIP-Seq_ESCs_Human0.75910830
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74828008
83ER_23166858_ChIP-Seq_MCF-7_Human0.74178361
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73242774
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.71286643
86MYC_22102868_ChIP-Seq_BL_Human0.70533445
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.70133510
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69886044
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69785599
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69684390
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.67463386
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67378928
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.67205214
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.66443494
95SMRT_27268052_Chip-Seq_Bcells_Human0.66377316
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66268470
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.65304720
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.65304720
99GATA2_19941826_ChIP-Seq_K562_Human0.64432586
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61962926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.88908033
2MP0003763_abnormal_thymus_physiology4.51471467
3MP0001835_abnormal_antigen_presentation3.81048516
4MP0009785_altered_susceptibility_to3.32338617
5MP0001800_abnormal_humoral_immune3.11448002
6MP0005000_abnormal_immune_tolerance2.97538801
7MP0002420_abnormal_adaptive_immunity2.73197245
8MP0002723_abnormal_immune_serum2.72329728
9MP0002148_abnormal_hypersensitivity_rea2.69484971
10MP0001819_abnormal_immune_cell2.67124176
11MP0005025_abnormal_response_to2.65239122
12MP0000685_abnormal_immune_system2.64776942
13MP0005387_immune_system_phenotype2.63287824
14MP0001790_abnormal_immune_system2.63287824
15MP0000703_abnormal_thymus_morphology2.51693473
16MP0010155_abnormal_intestine_physiology2.40396598
17MP0002398_abnormal_bone_marrow2.38555720
18MP0009333_abnormal_splenocyte_physiolog2.35176909
19MP0003866_abnormal_defecation2.33650145
20MP0002452_abnormal_antigen_presenting2.29132479
21MP0000716_abnormal_immune_system2.27015123
22MP0002405_respiratory_system_inflammati2.25604399
23MP0004381_abnormal_hair_follicle2.21724983
24MP0002722_abnormal_immune_system2.21353501
25MP0006082_CNS_inflammation2.19201909
26MP0000689_abnormal_spleen_morphology2.08226799
27MP0002138_abnormal_hepatobiliary_system2.00715394
28MP0002419_abnormal_innate_immunity1.95172111
29MP0001845_abnormal_inflammatory_respons1.95167792
30MP0003724_increased_susceptibility_to1.92019505
31MP0005377_hearing/vestibular/ear_phenot1.91297075
32MP0003878_abnormal_ear_physiology1.91297075
33MP0001188_hyperpigmentation1.80284123
34MP0001853_heart_inflammation1.79795196
35MP0002429_abnormal_blood_cell1.77145945
36MP0005075_abnormal_melanosome_morpholog1.72668171
37MP0001873_stomach_inflammation1.70078896
38MP0002396_abnormal_hematopoietic_system1.67186214
39MP0002166_altered_tumor_susceptibility1.64647977
40MP0005464_abnormal_platelet_physiology1.64352501
41MP0002006_tumorigenesis1.58792730
42MP0002933_joint_inflammation1.53773622
43MP0003448_altered_tumor_morphology1.49315775
44MP0003436_decreased_susceptibility_to1.45707494
45MP0004947_skin_inflammation1.37187036
46MP0005310_abnormal_salivary_gland1.34916857
47MP0002132_abnormal_respiratory_system1.29227071
48MP0009764_decreased_sensitivity_to1.23020470
49MP0006035_abnormal_mitochondrial_morpho1.22299244
50MP0003045_fibrosis1.15193901
51MP0008469_abnormal_protein_level1.14710501
52MP0004145_abnormal_muscle_electrophysio1.07650997
53MP0000858_altered_metastatic_potential1.05313708
54MP0002837_dystrophic_cardiac_calcinosis0.99226713
55MP0003075_altered_response_to0.95605196
56MP0005174_abnormal_tail_pigmentation0.94891268
57MP0003300_gastrointestinal_ulcer0.92909204
58MP0002019_abnormal_tumor_incidence0.91336104
59MP0009763_increased_sensitivity_to0.90570287
60MP0003183_abnormal_peptide_metabolism0.90238392
61MP0002998_abnormal_bone_remodeling0.88764447
62MP0002277_abnormal_respiratory_mucosa0.84350366
63MP0005166_decreased_susceptibility_to0.84073904
64MP0003786_premature_aging0.81145464
65MP0002163_abnormal_gland_morphology0.80311684
66MP0001661_extended_life_span0.77212510
67MP0004084_abnormal_cardiac_muscle0.72725386
68MP0008873_increased_physiological_sensi0.72534517
69MP0009765_abnormal_xenobiotic_induced0.70856045
70MP0004036_abnormal_muscle_relaxation0.70669945
71MP0005410_abnormal_fertilization0.69879534
72MP0003646_muscle_fatigue0.67781356
73MP0002876_abnormal_thyroid_physiology0.66537096
74MP0010307_abnormal_tumor_latency0.64296597
75MP0001905_abnormal_dopamine_level0.64193230
76MP0002877_abnormal_melanocyte_morpholog0.63381316
77MP0004484_altered_response_of0.62148442
78MP0000015_abnormal_ear_pigmentation0.60357218
79MP0004130_abnormal_muscle_cell0.59810656
80MP0002693_abnormal_pancreas_physiology0.59303231
81MP0001485_abnormal_pinna_reflex0.58789360
82MP0002638_abnormal_pupillary_reflex0.58023116
83MP0001986_abnormal_taste_sensitivity0.57723334
84MP0002136_abnormal_kidney_physiology0.57429456
85MP0003172_abnormal_lysosome_physiology0.52872915
86MP0008004_abnormal_stomach_pH0.52229070
87MP0000465_gastrointestinal_hemorrhage0.51449687
88MP0000681_abnormal_thyroid_gland0.50986944
89MP0000569_abnormal_digit_pigmentation0.50681010
90MP0000249_abnormal_blood_vessel0.50628069
91MP0001968_abnormal_touch/_nociception0.50527463
92MP0000920_abnormal_myelination0.50387348
93MP0006036_abnormal_mitochondrial_physio0.50246019
94MP0005319_abnormal_enzyme/_coenzyme0.49318771
95MP0009643_abnormal_urine_homeostasis0.49244426
96MP0001502_abnormal_circadian_rhythm0.48633945
97MP0001533_abnormal_skeleton_physiology0.48419178
98MP0005645_abnormal_hypothalamus_physiol0.47012807
99MP0000477_abnormal_intestine_morphology0.46659632
100MP0002083_premature_death0.45082192

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.50626614
2Abnormality of T cell number (HP:0011839)7.05315610
3Severe combined immunodeficiency (HP:0004430)5.77340223
4IgG deficiency (HP:0004315)5.52024187
5Abnormal delayed hypersensitivity skin test (HP:0002963)5.45907740
6Abnormality of T cells (HP:0002843)5.25761727
7Recurrent cutaneous fungal infections (HP:0011370)5.16850142
8Chronic mucocutaneous candidiasis (HP:0002728)5.16850142
9Panhypogammaglobulinemia (HP:0003139)5.04002197
10Thyroiditis (HP:0100646)4.92495707
11Combined immunodeficiency (HP:0005387)4.68310748
12Abnormality of eosinophils (HP:0001879)4.30308435
13Hypoproteinemia (HP:0003075)4.24097191
14Recurrent fungal infections (HP:0002841)4.17709015
15Hypoplasia of the thymus (HP:0000778)4.17571046
16Chronic diarrhea (HP:0002028)4.14486286
17Increased IgM level (HP:0003496)4.12426652
18Encephalitis (HP:0002383)4.10496841
19Optic neuritis (HP:0100653)4.00379627
20Retrobulbar optic neuritis (HP:0100654)4.00379627
21Myositis (HP:0100614)3.86250000
22Recurrent bronchitis (HP:0002837)3.79522941
23Autoimmune hemolytic anemia (HP:0001890)3.78791259
24Recurrent viral infections (HP:0004429)3.69976075
25Agammaglobulinemia (HP:0004432)3.68205684
26Eosinophilia (HP:0001880)3.63787974
27Meningitis (HP:0001287)3.56198598
28Abnormality of B cell number (HP:0010975)3.53723321
29Elevated erythrocyte sedimentation rate (HP:0003565)3.51005288
30Granulocytopenia (HP:0001913)3.47353465
31Orchitis (HP:0100796)3.46818273
32Leukocytosis (HP:0001974)3.36067809
33Abnormality of T cell physiology (HP:0011840)3.34929531
34Vasculitis (HP:0002633)3.18387684
35Hemoptysis (HP:0002105)3.12263371
36Pustule (HP:0200039)2.96043776
37Recurrent skin infections (HP:0001581)2.92168358
38Keratoconjunctivitis sicca (HP:0001097)2.90245300
39B lymphocytopenia (HP:0010976)2.80514681
40Pulmonary infiltrates (HP:0002113)2.79504202
41Keratoconjunctivitis (HP:0001096)2.76190643
42Stomatitis (HP:0010280)2.75587049
43Gangrene (HP:0100758)2.72227021
44Pulmonary embolism (HP:0002204)2.66273967
45Autoimmune thrombocytopenia (HP:0001973)2.63805151
46Colitis (HP:0002583)2.60262797
47Stomach cancer (HP:0012126)2.53035456
48IgM deficiency (HP:0002850)2.48875970
49Abnormality of the prostate (HP:0008775)2.47744968
50Acute hepatic failure (HP:0006554)2.44951395
51Aplastic anemia (HP:0001915)2.44706079
52Lymphoma (HP:0002665)2.42012654
53Carpal bone hypoplasia (HP:0001498)2.41803115
54Abnormality of the columella (HP:0009929)2.38419650
55Chronic obstructive pulmonary disease (HP:0006510)2.37838397
56Obstructive lung disease (HP:0006536)2.37838397
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33478093
58Lymphopenia (HP:0001888)2.32448791
59Thoracic kyphosis (HP:0002942)2.30681707
60Inflammation of the large intestine (HP:0002037)2.30325358
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.29450639
62Abnormality of the pleura (HP:0002103)2.26650799
63Abnormality of macrophages (HP:0004311)2.26271629
64Gastrointestinal infarctions (HP:0005244)2.24639563
65Spontaneous hematomas (HP:0007420)2.23115149
66IgA deficiency (HP:0002720)2.21464917
67Gastrointestinal inflammation (HP:0004386)2.19959859
68Bronchitis (HP:0012387)2.16767995
693-Methylglutaconic aciduria (HP:0003535)2.14505248
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12276847
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12276847
72Recurrent abscess formation (HP:0002722)2.10161161
73Recurrent bacterial skin infections (HP:0005406)2.09191326
74Hemiplegia (HP:0002301)2.08517235
75Eczematoid dermatitis (HP:0000976)2.05800032
76Unsteady gait (HP:0002317)2.02797451
77Arterial thrombosis (HP:0004420)1.99715916
78Glomerulopathy (HP:0100820)1.95099001
79Anorexia (HP:0002039)1.91714127
80Polyneuropathy (HP:0001271)1.90516486
81Abnormal albumin level (HP:0012116)1.89550309
82Hypoalbuminemia (HP:0003073)1.89550309
83Chest pain (HP:0100749)1.89192732
84Aplasia/Hypoplasia of the thymus (HP:0010515)1.87742240
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86375156
86Hypergammaglobulinemia (HP:0010702)1.84473474
87Ureteral stenosis (HP:0000071)1.82062582
88Abnormality of the pericardium (HP:0001697)1.81216178
89Abnormality of lateral ventricle (HP:0030047)1.78011011
90Reduced antithrombin III activity (HP:0001976)1.76857294
91Ureteral obstruction (HP:0006000)1.76024886
92J-shaped sella turcica (HP:0002680)1.75267323
93Acne (HP:0001061)1.73125319
94Keratitis (HP:0000491)1.71371759
95Abnormal biliary tract physiology (HP:0012439)1.70391583
96Bile duct proliferation (HP:0001408)1.70391583
97Lower limb hyperreflexia (HP:0002395)1.68477828
98Pigmentary retinal degeneration (HP:0001146)1.68223376
99Global brain atrophy (HP:0002283)1.68090185
100Abnormality of DNA repair (HP:0003254)1.66949581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.19394705
2ZAK3.65377166
3KDR3.53912820
4MAP4K13.28355010
5FES2.62134455
6ZAP702.56571569
7NLK2.47011981
8TRIM282.40544501
9ADRBK22.04212007
10ITK2.01377644
11TAOK31.86469414
12PRKCQ1.80875614
13SYK1.77161987
14MST41.75328529
15PIK3CG1.67885464
16BTK1.58407183
17EPHA31.56934990
18CSK1.55607350
19MARK31.52540622
20JAK11.52459824
21MUSK1.52350706
22JAK31.50674988
23TLK11.50163965
24GRK61.43039460
25RIPK41.37571896
26LCK1.27731411
27GRK71.21425964
28TESK21.20809711
29BUB11.19793731
30MAP2K71.18294465
31PINK11.17565650
32BLK1.12507682
33IKBKE1.11373402
34FRK1.06971078
35NEK21.05490040
36MAP3K121.03856677
37CSNK1A1L1.03482107
38MAPKAPK31.00931259
39TEC0.99165769
40BCKDK0.98617367
41MAP3K30.97060898
42MYLK0.97057121
43CSNK1G30.96468675
44IRAK40.95499814
45IKBKB0.90922344
46AKT30.90841410
47EPHB10.89110366
48HCK0.83943639
49MAP2K30.83825019
50MAP3K140.81294174
51LYN0.79999491
52SGK20.76298369
53PDGFRB0.76195942
54EIF2AK30.71763293
55SRPK10.71398511
56CDC70.69918409
57RPS6KA40.69406548
58DAPK10.68733357
59TBK10.64437917
60MAP3K50.63843517
61HIPK20.63401495
62VRK10.61959119
63JAK20.61938674
64SGK4940.60572058
65SGK2230.60572058
66TYRO30.60377313
67IRAK10.60196657
68RPS6KA50.59065098
69PIK3CA0.58497858
70CLK10.57644339
71CSNK1G20.56380791
72FGFR40.55932512
73MAP2K60.54992985
74MAPK120.53496544
75CSNK1G10.51414834
76BMPR20.49627367
77MELK0.49314256
78WNK40.48589178
79CDK30.47044659
80GRK50.45986632
81CSF1R0.45190737
82MAP3K130.43221938
83MAP3K10.42773618
84TNK20.41769722
85TGFBR20.40405189
86SGK30.40097380
87PIM10.39902123
88RET0.38286843
89GRK10.37874823
90FGFR30.34469506
91FYN0.33827700
92TRPM70.33337665
93IGF1R0.31366086
94PDK10.29984596
95KIT0.29962838
96ATR0.29287904
97OBSCN0.29095673
98CHUK0.28705938
99MAPKAPK20.28033189
100TIE10.27161281

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.47079450
2Antigen processing and presentation_Homo sapiens_hsa046123.79237739
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.40237391
4T cell receptor signaling pathway_Homo sapiens_hsa046603.33163890
5Graft-versus-host disease_Homo sapiens_hsa053323.29821669
6Autoimmune thyroid disease_Homo sapiens_hsa053203.22899055
7Allograft rejection_Homo sapiens_hsa053302.91442992
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.88156276
9Hematopoietic cell lineage_Homo sapiens_hsa046402.70674997
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.59185738
11Rheumatoid arthritis_Homo sapiens_hsa053232.36555903
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.35382601
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14403168
14Type I diabetes mellitus_Homo sapiens_hsa049402.10529636
15Measles_Homo sapiens_hsa051622.01332435
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.98635883
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89547337
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88260363
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75373532
20Chemokine signaling pathway_Homo sapiens_hsa040621.73793787
21Phototransduction_Homo sapiens_hsa047441.56174397
22Proteasome_Homo sapiens_hsa030501.55348949
23Malaria_Homo sapiens_hsa051441.42597434
24Salmonella infection_Homo sapiens_hsa051321.42240131
25Olfactory transduction_Homo sapiens_hsa047401.41066349
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32757965
27TNF signaling pathway_Homo sapiens_hsa046681.29389173
28Viral myocarditis_Homo sapiens_hsa054161.24624903
29Systemic lupus erythematosus_Homo sapiens_hsa053221.20008720
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14553115
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.14058065
32Osteoclast differentiation_Homo sapiens_hsa043801.07420948
33Shigellosis_Homo sapiens_hsa051311.07045624
34Staphylococcus aureus infection_Homo sapiens_hsa051501.05414665
35B cell receptor signaling pathway_Homo sapiens_hsa046621.04700245
36Herpes simplex infection_Homo sapiens_hsa051681.03397662
37Asthma_Homo sapiens_hsa053101.02146503
38Leishmaniasis_Homo sapiens_hsa051401.01451287
39Apoptosis_Homo sapiens_hsa042100.91473310
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78619885
41HTLV-I infection_Homo sapiens_hsa051660.75359297
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74287497
43Tuberculosis_Homo sapiens_hsa051520.74157620
44Pertussis_Homo sapiens_hsa051330.71085881
45Renin secretion_Homo sapiens_hsa049240.70553386
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68324627
47Epstein-Barr virus infection_Homo sapiens_hsa051690.63018292
48Alcoholism_Homo sapiens_hsa050340.62245372
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59055948
50Viral carcinogenesis_Homo sapiens_hsa052030.58913915
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58394875
52Toxoplasmosis_Homo sapiens_hsa051450.49394819
53Influenza A_Homo sapiens_hsa051640.48373956
54RNA polymerase_Homo sapiens_hsa030200.47436907
55Acute myeloid leukemia_Homo sapiens_hsa052210.47018280
56Hepatitis B_Homo sapiens_hsa051610.45505909
57Homologous recombination_Homo sapiens_hsa034400.44609038
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.39390669
59Prion diseases_Homo sapiens_hsa050200.39222059
60Legionellosis_Homo sapiens_hsa051340.39013007
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38802149
62Oxidative phosphorylation_Homo sapiens_hsa001900.38180303
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.36376974
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36162500
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35493633
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34821641
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34040076
68African trypanosomiasis_Homo sapiens_hsa051430.33867460
69Parkinsons disease_Homo sapiens_hsa050120.32099728
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32024925
71Platelet activation_Homo sapiens_hsa046110.29371409
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27963380
73Butanoate metabolism_Homo sapiens_hsa006500.27183938
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25301284
75Salivary secretion_Homo sapiens_hsa049700.25247431
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23902556
77Oxytocin signaling pathway_Homo sapiens_hsa049210.23288214
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22028238
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21129065
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20890570
81Alzheimers disease_Homo sapiens_hsa050100.19935516
82Peroxisome_Homo sapiens_hsa041460.18806042
83Pyrimidine metabolism_Homo sapiens_hsa002400.18721325
84Circadian entrainment_Homo sapiens_hsa047130.17166932
85Non-small cell lung cancer_Homo sapiens_hsa052230.16882697
86Endocytosis_Homo sapiens_hsa041440.16420876
87RNA degradation_Homo sapiens_hsa030180.15327311
88Calcium signaling pathway_Homo sapiens_hsa040200.14595561
89Purine metabolism_Homo sapiens_hsa002300.13286953
90Arachidonic acid metabolism_Homo sapiens_hsa005900.12661886
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.12520821
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.12182903
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11910555
94Fanconi anemia pathway_Homo sapiens_hsa034600.11755756
95Phagosome_Homo sapiens_hsa041450.09755952
96Ras signaling pathway_Homo sapiens_hsa040140.09702885
97Basal transcription factors_Homo sapiens_hsa030220.08753525
98Inositol phosphate metabolism_Homo sapiens_hsa005620.07284450
99Gastric acid secretion_Homo sapiens_hsa049710.07160843
100Sulfur metabolism_Homo sapiens_hsa009200.07033142

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