TRGJP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.99220406
2cytidine deamination (GO:0009972)7.99220406
3cytidine metabolic process (GO:0046087)7.99220406
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.07288618
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.76879676
6eosinophil chemotaxis (GO:0048245)6.53933147
7DNA deamination (GO:0045006)6.51323172
8positive regulation of monocyte chemotaxis (GO:0090026)6.25888748
9negative regulation by host of viral transcription (GO:0043922)6.18836628
10regulation of interleukin-12 biosynthetic process (GO:0045075)6.15393642
11regulation of activation of Janus kinase activity (GO:0010533)6.01161064
12eosinophil migration (GO:0072677)6.00175060
13regulation of B cell receptor signaling pathway (GO:0050855)5.99340068
14T cell migration (GO:0072678)5.96751745
15positive thymic T cell selection (GO:0045059)5.73986015
16regulation of lymphocyte chemotaxis (GO:1901623)5.73597001
17positive T cell selection (GO:0043368)5.59664750
18response to interleukin-15 (GO:0070672)5.54508891
19cellular response to interleukin-15 (GO:0071350)5.48206825
20positive regulation of interleukin-8 secretion (GO:2000484)5.44507354
21regulation of T cell chemotaxis (GO:0010819)5.43279559
22positive regulation of T cell chemotaxis (GO:0010820)5.43279559
23regulation of regulatory T cell differentiation (GO:0045589)5.24912459
24negative regulation of T cell apoptotic process (GO:0070233)5.24534503
25positive regulation of gamma-delta T cell activation (GO:0046645)5.22112946
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.75802299
27regulation of chronic inflammatory response (GO:0002676)4.75340017
28positive regulation of natural killer cell mediated immunity (GO:0002717)4.69661970
29positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.57854740
30positive regulation of lymphocyte migration (GO:2000403)4.57504382
31macrophage chemotaxis (GO:0048246)4.46996328
32regulation of gamma-delta T cell differentiation (GO:0045586)4.40568204
33dendritic cell chemotaxis (GO:0002407)4.27032690
34regulation of monocyte chemotaxis (GO:0090025)4.25168399
35positive regulation of calcium-mediated signaling (GO:0050850)4.22508379
36regulation of natural killer cell mediated immunity (GO:0002715)4.15215171
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.15215171
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09143883
39negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.03632545
40regulation of chemokine-mediated signaling pathway (GO:0070099)4.01928065
41positive regulation of translational initiation (GO:0045948)3.99029379
42negative T cell selection (GO:0043383)3.93406827
43regulation of interleukin-8 secretion (GO:2000482)3.91562865
44regulation of macrophage chemotaxis (GO:0010758)3.89584451
45regulation of mononuclear cell migration (GO:0071675)3.88310232
46membrane raft organization (GO:0031579)3.84350519
47lymphocyte chemotaxis (GO:0048247)3.83336840
48positive regulation of cell adhesion mediated by integrin (GO:0033630)3.82981836
49protein neddylation (GO:0045116)3.82825394
50thymic T cell selection (GO:0045061)3.82518356
51natural killer cell activation (GO:0030101)3.80897561
52T cell selection (GO:0045058)3.77214915
53negative regulation of lymphocyte apoptotic process (GO:0070229)3.76436461
54cytolysis (GO:0019835)3.76348384
55granulocyte activation (GO:0036230)3.75798374
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.74414829
57regulation of gamma-delta T cell activation (GO:0046643)3.74003198
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.72594824
59regulation of T cell receptor signaling pathway (GO:0050856)3.72105761
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.70023749
61cellular defense response (GO:0006968)3.68449964
62regulation of B cell differentiation (GO:0045577)3.68132425
63dendritic cell migration (GO:0036336)3.65915678
64positive regulation of T cell apoptotic process (GO:0070234)3.61922159
65negative regulation of T cell receptor signaling pathway (GO:0050860)3.60549171
66regulation of lymphocyte migration (GO:2000401)3.59681225
67positive regulation of T cell migration (GO:2000406)3.58480495
68chemokine-mediated signaling pathway (GO:0070098)3.57882477
69localization within membrane (GO:0051668)3.53763528
70lymphocyte migration (GO:0072676)3.53060478
71negative regulation of viral transcription (GO:0032897)3.52052379
72positive regulation of tolerance induction (GO:0002645)3.51105558
73lymph node development (GO:0048535)3.48655746
74adaptation of signaling pathway (GO:0023058)3.48252755
75DNA demethylation (GO:0080111)3.47943080
76diterpenoid biosynthetic process (GO:0016102)3.47645211
77T cell costimulation (GO:0031295)3.46922269
78monocyte chemotaxis (GO:0002548)3.45542193
79lymphocyte costimulation (GO:0031294)3.42536951
80negative regulation of viral genome replication (GO:0045071)3.41080622
81regulation of T cell tolerance induction (GO:0002664)3.36356281
82positive regulation of cell killing (GO:0031343)3.33529250
83negative regulation of B cell proliferation (GO:0030889)3.33480597
84B cell receptor signaling pathway (GO:0050853)3.31750435
85antigen receptor-mediated signaling pathway (GO:0050851)3.31713652
86T cell receptor signaling pathway (GO:0050852)3.31647745
87regulation of leukocyte mediated cytotoxicity (GO:0001910)3.28931570
88regulation of T cell apoptotic process (GO:0070232)3.27978318
89regulation of calcium-mediated signaling (GO:0050848)3.26870854
90modulation by host of viral transcription (GO:0043921)3.25117707
91modulation by host of symbiont transcription (GO:0052472)3.25117707
92regulation of isotype switching to IgG isotypes (GO:0048302)3.23969200
93regulation of homotypic cell-cell adhesion (GO:0034110)3.22387349
94T cell mediated immunity (GO:0002456)3.20942962
95positive regulation of macrophage differentiation (GO:0045651)3.19859462
96Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19419660
97negative regulation of T cell activation (GO:0050868)3.19230546
98hepatocyte apoptotic process (GO:0097284)3.18202920
99signal peptide processing (GO:0006465)3.18167213
100regulation of T cell migration (GO:2000404)3.17638685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.82231994
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.49083793
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.40447593
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33289785
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.30365397
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.08298605
7MYB_26560356_Chip-Seq_TH2_Human3.24031323
8RUNX_20019798_ChIP-Seq_JUKART_Human3.09666981
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91744689
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.90684697
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90557981
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.69923368
13GATA3_27048872_Chip-Seq_THYMUS_Human2.59813383
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56949541
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44815186
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36508095
17UTX_26944678_Chip-Seq_JUKART_Human2.33788452
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24970654
19MYB_26560356_Chip-Seq_TH1_Human2.23256050
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11895569
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.09589146
22BP1_19119308_ChIP-ChIP_Hs578T_Human11.8958237
23MAF_26560356_Chip-Seq_TH2_Human1.98849359
24MAF_26560356_Chip-Seq_TH1_Human1.87446880
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85681306
26SPI1_23547873_ChIP-Seq_NB4_Human1.85551926
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.84221780
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83814066
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77415759
30GATA3_26560356_Chip-Seq_TH2_Human1.76896853
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64272218
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59802604
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45093696
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42171664
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.38061889
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36929034
37GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32375114
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29965529
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29036793
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23466602
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.21930222
42VDR_23849224_ChIP-Seq_CD4+_Human1.21602738
43VDR_21846776_ChIP-Seq_THP-1_Human1.20454355
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19097332
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17134787
46SPI1_23127762_ChIP-Seq_K562_Human1.12873277
47VDR_24763502_ChIP-Seq_THP-1_Human1.12044918
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08092957
49VDR_22108803_ChIP-Seq_LS180_Human1.07151911
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04517673
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03337943
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02603625
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00908532
54ELF1_20517297_ChIP-Seq_JURKAT_Human0.98280856
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98083053
56NOTCH1_21737748_ChIP-Seq_TLL_Human0.97265885
57HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96949502
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96758489
59GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96648347
60GATA3_26560356_Chip-Seq_TH1_Human0.96373053
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94712589
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94391587
63FOXP3_21729870_ChIP-Seq_TREG_Human0.91468724
64RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91433668
65MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91354548
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89039757
67SCL_19346495_ChIP-Seq_HPC-7_Human0.85510993
68FLI1_27457419_Chip-Seq_LIVER_Mouse0.84953165
69CIITA_25753668_ChIP-Seq_RAJI_Human0.83807634
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83444152
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78982868
72BCL6_27268052_Chip-Seq_Bcells_Human0.78473643
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78236665
74TAF15_26573619_Chip-Seq_HEK293_Human0.77846596
75TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77844202
76FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75598817
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74404668
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74119332
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73123116
80TP53_22573176_ChIP-Seq_HFKS_Human0.71423758
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71131138
82GATA1_22025678_ChIP-Seq_K562_Human0.70505729
83P300_27268052_Chip-Seq_Bcells_Human0.67998856
84TAF2_19829295_ChIP-Seq_ESCs_Human0.67552787
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.66298928
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66202596
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.66050276
88BCOR_27268052_Chip-Seq_Bcells_Human0.65502141
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.65493129
90POU5F1_16518401_ChIP-PET_MESCs_Mouse0.65295987
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.64522649
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.62374408
93VDR_24787735_ChIP-Seq_THP-1_Human0.62080485
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61606404
95HTT_18923047_ChIP-ChIP_STHdh_Human0.61508532
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61037416
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.60963081
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.58601924
99MYC_22102868_ChIP-Seq_BL_Human0.58221129
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.58109287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.46593370
2MP0009785_altered_susceptibility_to4.24688267
3MP0003866_abnormal_defecation3.79889556
4MP0006082_CNS_inflammation3.33423111
5MP0001835_abnormal_antigen_presentation3.18068133
6MP0003763_abnormal_thymus_physiology3.12357907
7MP0000569_abnormal_digit_pigmentation3.10342146
8MP0005025_abnormal_response_to2.98883923
9MP0001800_abnormal_humoral_immune2.93894042
10MP0005000_abnormal_immune_tolerance2.75694749
11MP0002148_abnormal_hypersensitivity_rea2.68756539
12MP0002420_abnormal_adaptive_immunity2.68396982
13MP0010155_abnormal_intestine_physiology2.66717312
14MP0001819_abnormal_immune_cell2.65377173
15MP0002723_abnormal_immune_serum2.54941451
16MP0002405_respiratory_system_inflammati2.45480240
17MP0002398_abnormal_bone_marrow2.30342815
18MP0002452_abnormal_antigen_presenting2.20143354
19MP0003448_altered_tumor_morphology2.15812735
20MP0000716_abnormal_immune_system2.15573437
21MP0002166_altered_tumor_susceptibility2.14889924
22MP0002396_abnormal_hematopoietic_system2.12501006
23MP0003436_decreased_susceptibility_to2.12290207
24MP0005464_abnormal_platelet_physiology2.07883131
25MP0002419_abnormal_innate_immunity2.05852360
26MP0005387_immune_system_phenotype1.97340795
27MP0001790_abnormal_immune_system1.97340795
28MP0002722_abnormal_immune_system1.95569098
29MP0000689_abnormal_spleen_morphology1.89265641
30MP0001845_abnormal_inflammatory_respons1.86561875
31MP0005174_abnormal_tail_pigmentation1.85071806
32MP0000703_abnormal_thymus_morphology1.82573278
33MP0002429_abnormal_blood_cell1.75187091
34MP0009333_abnormal_splenocyte_physiolog1.62086390
35MP0003724_increased_susceptibility_to1.58786269
36MP0000685_abnormal_immune_system1.58117540
37MP0002006_tumorigenesis1.56435548
38MP0003045_fibrosis1.55688442
39MP0003183_abnormal_peptide_metabolism1.48502302
40MP0005377_hearing/vestibular/ear_phenot1.43288379
41MP0003878_abnormal_ear_physiology1.43288379
42MP0003011_delayed_dark_adaptation1.42937077
43MP0002877_abnormal_melanocyte_morpholog1.42022653
44MP0001873_stomach_inflammation1.40472178
45MP0003172_abnormal_lysosome_physiology1.39728045
46MP0000015_abnormal_ear_pigmentation1.38358273
47MP0001853_heart_inflammation1.33452528
48MP0008469_abnormal_protein_level1.30488739
49MP0004947_skin_inflammation1.30419213
50MP0005310_abnormal_salivary_gland1.27978686
51MP0004185_abnormal_adipocyte_glucose1.20415452
52MP0002933_joint_inflammation1.18244380
53MP0009763_increased_sensitivity_to1.14579955
54MP0004381_abnormal_hair_follicle1.14254051
55MP0010307_abnormal_tumor_latency1.09927815
56MP0002095_abnormal_skin_pigmentation1.08205961
57MP0009765_abnormal_xenobiotic_induced1.06611934
58MP0004130_abnormal_muscle_cell1.05963669
59MP0005166_decreased_susceptibility_to1.03066600
60MP0000858_altered_metastatic_potential1.02206945
61MP0005075_abnormal_melanosome_morpholog1.01966307
62MP0008260_abnormal_autophagy0.99988970
63MP0003806_abnormal_nucleotide_metabolis0.99075421
64MP0002132_abnormal_respiratory_system0.98059753
65MP0005058_abnormal_lysosome_morphology0.94679147
66MP0001661_extended_life_span0.93005247
67MP0002998_abnormal_bone_remodeling0.90690873
68MP0005670_abnormal_white_adipose0.88676525
69MP0005379_endocrine/exocrine_gland_phen0.86770461
70MP0009764_decreased_sensitivity_to0.85043617
71MP0004134_abnormal_chest_morphology0.84968711
72MP0002163_abnormal_gland_morphology0.81583940
73MP0006054_spinal_hemorrhage0.81484060
74MP0004808_abnormal_hematopoietic_stem0.78533803
75MP0000343_altered_response_to0.73907315
76MP0002277_abnormal_respiratory_mucosa0.73497415
77MP0008961_abnormal_basal_metabolism0.72718969
78MP0008873_increased_physiological_sensi0.71826580
79MP0003137_abnormal_impulse_conducting0.70141964
80MP0005319_abnormal_enzyme/_coenzyme0.67927824
81MP0001485_abnormal_pinna_reflex0.67672891
82MP0002019_abnormal_tumor_incidence0.67408112
83MP0002693_abnormal_pancreas_physiology0.60863023
84MP0001533_abnormal_skeleton_physiology0.59571714
85MP0003786_premature_aging0.56738711
86MP0003943_abnormal_hepatobiliary_system0.56050473
87MP0004782_abnormal_surfactant_physiolog0.55863201
88MP0005666_abnormal_adipose_tissue0.55755476
89MP0003690_abnormal_glial_cell0.55631494
90MP0002009_preneoplasia0.54864112
91MP0000477_abnormal_intestine_morphology0.53929214
92MP0001666_abnormal_nutrient_absorption0.53215931
93MP0002138_abnormal_hepatobiliary_system0.50853436
94MP0004883_abnormal_blood_vessel0.50607572
95MP0000920_abnormal_myelination0.49812114
96MP0001188_hyperpigmentation0.48721240
97MP0008770_decreased_survivor_rate0.48657804
98MP0009643_abnormal_urine_homeostasis0.44658960
99MP0002136_abnormal_kidney_physiology0.44317716
100MP0000490_abnormal_crypts_of0.43004444

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.61631438
2Abnormality of T cell number (HP:0011839)7.04122516
3Abnormality of T cells (HP:0002843)5.71416870
4Chronic diarrhea (HP:0002028)5.23244081
5Aplastic anemia (HP:0001915)4.86675751
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.65482091
7Autoimmune hemolytic anemia (HP:0001890)4.46234175
8Hypoproteinemia (HP:0003075)4.03243379
9Abnormality of T cell physiology (HP:0011840)3.78015962
10Recurrent viral infections (HP:0004429)3.76515268
11Meningitis (HP:0001287)3.75177068
12Abnormality of the prostate (HP:0008775)3.74947645
13IgG deficiency (HP:0004315)3.70718709
14Recurrent fungal infections (HP:0002841)3.60683554
15Panhypogammaglobulinemia (HP:0003139)3.57784752
163-Methylglutaconic aciduria (HP:0003535)3.57740524
17Gastrointestinal infarctions (HP:0005244)3.56746788
18J-shaped sella turcica (HP:0002680)3.55867255
19Lymphopenia (HP:0001888)3.50761694
20Recurrent bacterial skin infections (HP:0005406)3.32793480
21Pustule (HP:0200039)3.29560341
22Abnormality of cells of the lymphoid lineage (HP:0012140)3.29354017
23Obstructive lung disease (HP:0006536)3.24468816
24Chronic obstructive pulmonary disease (HP:0006510)3.24468816
25Severe combined immunodeficiency (HP:0004430)3.20529926
26Recurrent bronchitis (HP:0002837)3.20124994
27Stomatitis (HP:0010280)3.19961760
28Hemoptysis (HP:0002105)3.18183430
29Abnormal biliary tract physiology (HP:0012439)3.11670081
30Bile duct proliferation (HP:0001408)3.11670081
31Abnormality of macrophages (HP:0004311)3.11497675
32Joint swelling (HP:0001386)3.11069433
33Recurrent abscess formation (HP:0002722)3.06237825
34Chest pain (HP:0100749)3.05657427
35Gangrene (HP:0100758)3.03459908
36Recurrent cutaneous fungal infections (HP:0011370)3.01319031
37Chronic mucocutaneous candidiasis (HP:0002728)3.01319031
38IgM deficiency (HP:0002850)2.92788764
39Myositis (HP:0100614)2.92154875
40Vasculitis (HP:0002633)2.90910150
41Encephalitis (HP:0002383)2.88188369
42Pulmonary infiltrates (HP:0002113)2.87562881
43Increased IgM level (HP:0003496)2.84153783
44Abnormality of B cell number (HP:0010975)2.76408045
45Ureteral stenosis (HP:0000071)2.75333921
46Severe visual impairment (HP:0001141)2.73515802
47Abnormality of eosinophils (HP:0001879)2.72601719
48Retrobulbar optic neuritis (HP:0100654)2.70610493
49Optic neuritis (HP:0100653)2.70610493
50Abnormality of the alveolar ridges (HP:0006477)2.70024486
51Carpal bone hypoplasia (HP:0001498)2.64682565
52Recurrent skin infections (HP:0001581)2.61287085
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60092233
54Bronchitis (HP:0012387)2.59765122
55Hemiplegia (HP:0002301)2.55721550
56Ureteral obstruction (HP:0006000)2.51852703
57Elevated erythrocyte sedimentation rate (HP:0003565)2.50578255
58Combined immunodeficiency (HP:0005387)2.47848014
59Hepatosplenomegaly (HP:0001433)2.45669865
60IgA deficiency (HP:0002720)2.45418514
61Thyroiditis (HP:0100646)2.43755543
62Eosinophilia (HP:0001880)2.43700962
63Amaurosis fugax (HP:0100576)2.43507178
64Leukocytosis (HP:0001974)2.42650271
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38182179
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38182179
67Abnormality of oral frenula (HP:0000190)2.35379878
68Granulocytopenia (HP:0001913)2.34554898
69Recurrent otitis media (HP:0000403)2.33801175
70Agammaglobulinemia (HP:0004432)2.33418899
71Mediastinal lymphadenopathy (HP:0100721)2.30261024
72Pulmonary embolism (HP:0002204)2.30137637
73Orchitis (HP:0100796)2.28683169
74Zonular cataract (HP:0010920)2.26687499
75Poor speech (HP:0002465)2.26276152
76Acute hepatic failure (HP:0006554)2.26161808
77Abnormality of the pleura (HP:0002103)2.24793947
78Hypoplasia of the thymus (HP:0000778)2.21746092
79Lymphoma (HP:0002665)2.19319303
80Autoimmune thrombocytopenia (HP:0001973)2.18906352
81Stomach cancer (HP:0012126)2.18877120
82Anorexia (HP:0002039)2.17489529
83B lymphocytopenia (HP:0010976)2.17135555
84True hermaphroditism (HP:0010459)2.16052880
85Renal cortical cysts (HP:0000803)2.15037305
86Broad face (HP:0000283)2.13001835
87Pulmonary fibrosis (HP:0002206)2.09785226
88Arterial thrombosis (HP:0004420)2.09633972
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08384046
90Epistaxis (HP:0000421)2.07671854
91Pancreatic cysts (HP:0001737)2.05167281
92Keratoconjunctivitis sicca (HP:0001097)2.03540955
93Abnormality of male internal genitalia (HP:0000022)2.02497601
94Congenital stationary night blindness (HP:0007642)1.99098423
95Hypoalbuminemia (HP:0003073)1.97960167
96Abnormal albumin level (HP:0012116)1.97960167
97Neurodegeneration (HP:0002180)1.93966207
98Hematochezia (HP:0002573)1.93715928
99Increased intramyocellular lipid droplets (HP:0012240)1.92272719
100Abnormality of binocular vision (HP:0011514)1.90552285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.02862571
2KDR4.25856364
3FES3.52556356
4ITK3.50509275
5GRK73.32958238
6EIF2AK33.20727954
7TRIM282.64533439
8ZAK2.56429063
9BCKDK2.18073192
10TGFBR22.16108089
11JAK31.98767975
12SYK1.97085856
13MAP4K11.96917891
14TEC1.95134780
15MOS1.88957460
16ZAP701.84286697
17PRKCQ1.74248782
18BTK1.62701718
19CSK1.61634894
20STK161.58274991
21LCK1.50222858
22PIK3CG1.47270316
23STK101.41920723
24TAF11.39817639
25RIPK41.38966543
26MELK1.28702049
27MAP2K61.26935146
28TAOK31.25442811
29LYN1.24200906
30KIT1.23908400
31WNK41.17350781
32JAK21.16293957
33MST41.11479954
34CLK11.09588819
35PIK3CA1.08674682
36PDK11.05303524
37MAP3K121.05176312
38CSF1R1.00926918
39TESK20.95326413
40GRK50.92973842
41TBK10.92944796
42HCK0.92537731
43BUB10.89965911
44MAPKAPK30.88168727
45ADRBK20.86813264
46FYN0.85412736
47EIF2AK20.82917564
48JAK10.81253090
49BLK0.80557832
50IGF1R0.80039372
51PDK20.77677692
52MAPK150.74203746
53GRK10.72524686
54DAPK10.70255380
55FGR0.65350773
56EIF2AK10.61545809
57PRKCH0.60075327
58GRK60.55880198
59WNK10.53155335
60FRK0.50856475
61MATK0.49468156
62TIE10.48821786
63INSR0.48742474
64NEK60.45543410
65OXSR10.45445906
66MYLK0.45438957
67FLT30.44594576
68IRAK40.42871521
69TRPM70.41416583
70MAPKAPK20.40177084
71PIM10.39688306
72MAPK110.38838216
73IKBKE0.38126489
74TNK20.37037269
75MAPK30.37010441
76DAPK20.34134080
77TLK10.33573773
78ABL10.33349915
79IKBKB0.32831842
80CDK190.32729404
81RPS6KA50.32646361
82TYK20.32138644
83GSK3A0.30257381
84PRKCA0.28803971
85CDK60.28548989
86NTRK20.28292696
87ROCK10.27858532
88PDPK10.27745233
89MARK30.25977625
90MAP3K50.23304461
91STK110.22715455
92CDK40.20759720
93ADRBK10.20464372
94PDGFRB0.19176619
95VRK10.18116523
96IRAK10.16987851
97PRKCB0.16258139
98ACVR1B0.14932836
99PAK10.14907208
100SGK10.14405616

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.29177634
2Antigen processing and presentation_Homo sapiens_hsa046123.76437323
3Hematopoietic cell lineage_Homo sapiens_hsa046403.71056630
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.51271846
5T cell receptor signaling pathway_Homo sapiens_hsa046603.25040618
6Graft-versus-host disease_Homo sapiens_hsa053323.18877194
7Rheumatoid arthritis_Homo sapiens_hsa053233.03356979
8Autoimmune thyroid disease_Homo sapiens_hsa053202.90897602
9Allograft rejection_Homo sapiens_hsa053302.64277098
10Salmonella infection_Homo sapiens_hsa051322.63449004
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44621175
12Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.32893613
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.19059788
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15441428
15Type I diabetes mellitus_Homo sapiens_hsa049402.04679066
16Measles_Homo sapiens_hsa051622.03211239
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.86296587
18Proteasome_Homo sapiens_hsa030501.85863671
19Chemokine signaling pathway_Homo sapiens_hsa040621.72088710
20Malaria_Homo sapiens_hsa051441.39932127
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35265256
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34268885
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30217042
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28705167
25Leishmaniasis_Homo sapiens_hsa051401.22908135
26Prion diseases_Homo sapiens_hsa050201.18347298
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.17520717
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15034986
29Parkinsons disease_Homo sapiens_hsa050121.06692136
30Protein export_Homo sapiens_hsa030601.06667641
31Legionellosis_Homo sapiens_hsa051341.00454181
32TNF signaling pathway_Homo sapiens_hsa046680.98613718
33Viral myocarditis_Homo sapiens_hsa054160.97875824
34Oxidative phosphorylation_Homo sapiens_hsa001900.96430253
35Asthma_Homo sapiens_hsa053100.93566505
36Intestinal immune network for IgA production_Homo sapiens_hsa046720.92942227
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91955451
38Osteoclast differentiation_Homo sapiens_hsa043800.88940811
39HTLV-I infection_Homo sapiens_hsa051660.87759487
40Shigellosis_Homo sapiens_hsa051310.86897706
41Apoptosis_Homo sapiens_hsa042100.82398310
42African trypanosomiasis_Homo sapiens_hsa051430.81302427
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78582675
44B cell receptor signaling pathway_Homo sapiens_hsa046620.75917681
45Staphylococcus aureus infection_Homo sapiens_hsa051500.74898655
46Influenza A_Homo sapiens_hsa051640.72932500
47Systemic lupus erythematosus_Homo sapiens_hsa053220.72470853
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72135705
49Herpes simplex infection_Homo sapiens_hsa051680.72102422
50Caffeine metabolism_Homo sapiens_hsa002320.72021546
51Alzheimers disease_Homo sapiens_hsa050100.67770042
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63653969
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63340948
54Regulation of autophagy_Homo sapiens_hsa041400.61315359
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60160125
56Endocytosis_Homo sapiens_hsa041440.59514444
57Pertussis_Homo sapiens_hsa051330.56748488
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55883993
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55009814
60Epstein-Barr virus infection_Homo sapiens_hsa051690.52524491
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51374883
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.50570055
63Cardiac muscle contraction_Homo sapiens_hsa042600.49757645
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48787776
65Nitrogen metabolism_Homo sapiens_hsa009100.47455747
66Viral carcinogenesis_Homo sapiens_hsa052030.47126726
67Platelet activation_Homo sapiens_hsa046110.45796375
68Tuberculosis_Homo sapiens_hsa051520.41549165
69Hepatitis B_Homo sapiens_hsa051610.39014657
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.38502990
71Salivary secretion_Homo sapiens_hsa049700.34459036
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33514776
73Renin secretion_Homo sapiens_hsa049240.31352484
74Peroxisome_Homo sapiens_hsa041460.30888490
75RNA polymerase_Homo sapiens_hsa030200.30495078
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30385313
77Retinol metabolism_Homo sapiens_hsa008300.29070275
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25939197
79Amoebiasis_Homo sapiens_hsa051460.25356979
80Non-small cell lung cancer_Homo sapiens_hsa052230.24522747
81Huntingtons disease_Homo sapiens_hsa050160.23714796
82Long-term potentiation_Homo sapiens_hsa047200.22689051
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22392406
84Phagosome_Homo sapiens_hsa041450.21307119
85Alcoholism_Homo sapiens_hsa050340.19225786
86p53 signaling pathway_Homo sapiens_hsa041150.18993507
87Pancreatic secretion_Homo sapiens_hsa049720.17345559
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.16310399
89VEGF signaling pathway_Homo sapiens_hsa043700.15971633
90Calcium signaling pathway_Homo sapiens_hsa040200.15647598
91Dorso-ventral axis formation_Homo sapiens_hsa043200.14817000
92Glioma_Homo sapiens_hsa052140.12222782
93Amphetamine addiction_Homo sapiens_hsa050310.09521406
94Olfactory transduction_Homo sapiens_hsa047400.08832584
95Linoleic acid metabolism_Homo sapiens_hsa005910.08534746
96MAPK signaling pathway_Homo sapiens_hsa040100.07578427
97Renin-angiotensin system_Homo sapiens_hsa046140.07027662
98Pancreatic cancer_Homo sapiens_hsa052120.06280234
99Toxoplasmosis_Homo sapiens_hsa051450.05595997
100Acute myeloid leukemia_Homo sapiens_hsa052210.05533539

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