TREML3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.09664708
2positive regulation by symbiont of host defense response (GO:0052509)5.84682742
3modulation by symbiont of host defense response (GO:0052031)5.84682742
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.84682742
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.84682742
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.84682742
7modulation by symbiont of host immune response (GO:0052553)5.84682742
8response to peptidoglycan (GO:0032494)5.45186778
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.23953499
10negative regulation of cell killing (GO:0031342)5.12089475
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12089475
12detection of molecule of bacterial origin (GO:0032490)5.05522125
13cellular extravasation (GO:0045123)5.00019421
14detection of other organism (GO:0098543)4.95820757
15neutrophil activation (GO:0042119)4.95377525
16macrophage activation involved in immune response (GO:0002281)4.86220779
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.85964148
18positive regulation of gamma-delta T cell activation (GO:0046645)4.84237961
19negative regulation of interleukin-12 production (GO:0032695)4.74953932
20leukocyte migration involved in inflammatory response (GO:0002523)4.70223816
21granulocyte activation (GO:0036230)4.59572503
22detection of bacterium (GO:0016045)4.47557643
23detection of external biotic stimulus (GO:0098581)4.45805509
24regulation of interferon-beta biosynthetic process (GO:0045357)4.38642515
25response to host immune response (GO:0052572)4.05102229
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.05102229
27detection of biotic stimulus (GO:0009595)3.99659047
28microglial cell activation (GO:0001774)3.96747341
29negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.90870961
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90388797
31leukocyte aggregation (GO:0070486)3.88767920
32neutrophil mediated immunity (GO:0002446)3.88679174
33macrophage activation (GO:0042116)3.87637651
34regulation of mast cell degranulation (GO:0043304)3.85414320
35germinal center formation (GO:0002467)3.82772899
36regulation of B cell receptor signaling pathway (GO:0050855)3.80253986
37antigen processing and presentation of endogenous antigen (GO:0019883)3.75685191
38myeloid cell activation involved in immune response (GO:0002275)3.75510116
39regulation of T-helper 2 cell differentiation (GO:0045628)3.74616565
40respiratory burst (GO:0045730)3.72422282
41positive regulation of mast cell activation (GO:0033005)3.71485647
42response to host (GO:0075136)3.68655800
43response to host defenses (GO:0052200)3.68655800
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68655800
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.64673602
46negative regulation of T-helper cell differentiation (GO:0045623)3.59094495
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.59094495
48regulation of mast cell activation involved in immune response (GO:0033006)3.57402332
49regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.55334931
50production of molecular mediator involved in inflammatory response (GO:0002532)3.54373628
51regulation of gamma-delta T cell activation (GO:0046643)3.52795242
52immunoglobulin mediated immune response (GO:0016064)3.52267425
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.52065608
54regulation of mast cell activation (GO:0033003)3.49478476
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35772942
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33331902
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.32455178
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30230882
59leukocyte degranulation (GO:0043299)3.30002634
60regulation of leukocyte degranulation (GO:0043300)3.26032510
61response to muramyl dipeptide (GO:0032495)3.25446350
62positive regulation of toll-like receptor signaling pathway (GO:0034123)3.25229892
63negative regulation of leukocyte mediated immunity (GO:0002704)3.24130626
64positive regulation of cellular amide metabolic process (GO:0034250)3.21023898
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.16903277
66neutrophil chemotaxis (GO:0030593)3.16647254
67myeloid leukocyte mediated immunity (GO:0002444)3.14697271
68regulation of platelet aggregation (GO:0090330)3.13129213
69response to interleukin-15 (GO:0070672)3.12443799
70defense response to protozoan (GO:0042832)3.10975213
71negative regulation of T cell mediated immunity (GO:0002710)3.08817658
72neutrophil migration (GO:1990266)3.08304331
73positive regulation of mast cell degranulation (GO:0043306)3.07531019
74positive regulation of mast cell activation involved in immune response (GO:0033008)3.07531019
75negative regulation of cytokine production involved in immune response (GO:0002719)3.00751319
76regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00053125
77negative regulation of interleukin-6 production (GO:0032715)2.99756615
78negative regulation of interleukin-17 production (GO:0032700)2.99515857
79T-helper 1 type immune response (GO:0042088)2.97733028
80negative regulation of alpha-beta T cell activation (GO:0046636)2.96398297
81myeloid leukocyte activation (GO:0002274)2.96176732
82B cell mediated immunity (GO:0019724)2.92769749
83dendritic cell chemotaxis (GO:0002407)2.89744062
84positive regulation of interferon-alpha production (GO:0032727)2.88021463
85positive regulation of type 2 immune response (GO:0002830)2.86315689
86negative regulation of toll-like receptor signaling pathway (GO:0034122)2.85947042
87regulation of tolerance induction (GO:0002643)2.84401848
88regulation of interleukin-17 production (GO:0032660)2.82978778
89dendritic cell migration (GO:0036336)2.82975681
90regulation of macrophage cytokine production (GO:0010935)2.81671932
91type I interferon signaling pathway (GO:0060337)2.80939842
92cellular response to type I interferon (GO:0071357)2.80939842
93regulation of regulated secretory pathway (GO:1903305)2.80612536
94positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80521463
95positive regulation of interleukin-10 production (GO:0032733)2.80447940
96negative regulation of erythrocyte differentiation (GO:0045647)2.78804664
97regulation of toll-like receptor signaling pathway (GO:0034121)2.77911776
98response to type I interferon (GO:0034340)2.77498680
99negative regulation of interleukin-1 production (GO:0032692)2.76054992
100regulation of interferon-alpha production (GO:0032647)2.75860795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.39802178
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.25157719
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.21670537
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.83387133
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37680287
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37399107
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.28285254
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24364475
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.14087760
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06462834
11SPI1_23127762_ChIP-Seq_K562_Human2.71080303
12SCL_19346495_ChIP-Seq_HPC-7_Human2.70263068
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60854568
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54899400
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.54474056
16SPI1_23547873_ChIP-Seq_NB4_Human2.47728459
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44220329
18VDR_24763502_ChIP-Seq_THP-1_Human2.42598553
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39651498
20RUNX_20019798_ChIP-Seq_JUKART_Human2.36738920
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.27270540
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22885907
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17955466
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12903568
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10441823
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10372502
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.08754093
28VDR_21846776_ChIP-Seq_THP-1_Human1.99282111
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99121332
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98077864
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97127576
32MAF_26560356_Chip-Seq_TH1_Human1.95186761
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.94644671
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.92800369
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92462250
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91094482
37GATA1_22025678_ChIP-Seq_K562_Human1.90610107
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.90125851
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88756421
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.87803009
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86252292
42MYB_26560356_Chip-Seq_TH2_Human1.85108332
43GATA1_19941826_ChIP-Seq_K562_Human1.81326031
44UTX_26944678_Chip-Seq_JUKART_Human1.80903592
45VDR_24787735_ChIP-Seq_THP-1_Human1.79873228
46TCF7_22412390_ChIP-Seq_EML_Mouse1.77750200
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76479074
48GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70104165
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66040256
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.62409185
51MYB_26560356_Chip-Seq_TH1_Human1.57332819
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.54222613
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53967370
54MYC_22102868_ChIP-Seq_BL_Human1.48458529
55GATA2_19941826_ChIP-Seq_K562_Human1.47444848
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46026090
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45428294
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45336852
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44583599
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44524738
61PU_27001747_Chip-Seq_BMDM_Mouse1.41468047
62GATA3_27048872_Chip-Seq_THYMUS_Human1.40371301
63KDM2B_26808549_Chip-Seq_DND41_Human1.40211476
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32640672
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32456215
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30109161
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29444635
68MAF_26560356_Chip-Seq_TH2_Human1.28079137
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.26491164
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26100574
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25799525
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23920485
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22937294
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21385569
75GATA3_26560356_Chip-Seq_TH2_Human1.19722359
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17593998
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15020315
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13411986
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07429714
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07013434
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05735942
82NCOR1_26117541_ChIP-Seq_K562_Human1.03462925
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98527314
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.97232936
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96544009
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96489515
87LXR_22292898_ChIP-Seq_THP-1_Human0.89015131
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88753830
89SPI1_20517297_ChIP-Seq_HL60_Human0.88543788
90BCL6_27268052_Chip-Seq_Bcells_Human0.88220105
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88191902
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87791325
93BCOR_27268052_Chip-Seq_Bcells_Human0.85814093
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85558046
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83294829
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81907537
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80673507
98EGR1_19032775_ChIP-ChIP_M12_Human0.78008523
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77716820
100RXR_22158963_ChIP-Seq_LIVER_Mouse0.70445899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.74081856
2MP0003303_peritoneal_inflammation4.95176695
3MP0003436_decreased_susceptibility_to4.18169726
4MP0005464_abnormal_platelet_physiology3.41551277
5MP0001835_abnormal_antigen_presentation3.27062070
6MP0002419_abnormal_innate_immunity2.99969706
7MP0008004_abnormal_stomach_pH2.78355606
8MP0005000_abnormal_immune_tolerance2.68263095
9MP0009785_altered_susceptibility_to2.64420818
10MP0005025_abnormal_response_to2.61979605
11MP0002148_abnormal_hypersensitivity_rea2.46582454
12MP0001790_abnormal_immune_system2.41352344
13MP0005387_immune_system_phenotype2.41352344
14MP0001800_abnormal_humoral_immune2.41320724
15MP0000685_abnormal_immune_system2.39543750
16MP0005671_abnormal_response_to2.35960416
17MP0002723_abnormal_immune_serum2.33908940
18MP0001533_abnormal_skeleton_physiology2.28552333
19MP0009278_abnormal_bone_marrow2.25805393
20MP0002452_abnormal_antigen_presenting2.24103636
21MP0008260_abnormal_autophagy2.20541277
22MP0003191_abnormal_cellular_cholesterol2.20134662
23MP0006082_CNS_inflammation2.16960875
24MP0002420_abnormal_adaptive_immunity2.16409832
25MP0001819_abnormal_immune_cell2.14651669
26MP0003300_gastrointestinal_ulcer2.14634415
27MP0004510_myositis2.06522843
28MP0002132_abnormal_respiratory_system2.01529029
29MP0009764_decreased_sensitivity_to2.01106682
30MP0003828_pulmonary_edema1.94896027
31MP0004947_skin_inflammation1.93588264
32MP0000465_gastrointestinal_hemorrhage1.90161784
33MP0002405_respiratory_system_inflammati1.79737389
34MP0010155_abnormal_intestine_physiology1.76825829
35MP0001545_abnormal_hematopoietic_system1.75867056
36MP0005397_hematopoietic_system_phenotyp1.75867056
37MP0001845_abnormal_inflammatory_respons1.70110048
38MP0003075_altered_response_to1.69633840
39MP0003656_abnormal_erythrocyte_physiolo1.66904900
40MP0002398_abnormal_bone_marrow1.66393800
41MP0003172_abnormal_lysosome_physiology1.59523067
42MP0000716_abnormal_immune_system1.57396289
43MP0000343_altered_response_to1.48921927
44MP0005451_abnormal_body_composition1.48286511
45MP0000858_altered_metastatic_potential1.38932716
46MP0008469_abnormal_protein_level1.34627688
47MP0002722_abnormal_immune_system1.32841721
48MP0002429_abnormal_blood_cell1.29985290
49MP0000689_abnormal_spleen_morphology1.29925701
50MP0009333_abnormal_splenocyte_physiolog1.28970363
51MP0001851_eye_inflammation1.28169787
52MP0002998_abnormal_bone_remodeling1.28136691
53MP0002277_abnormal_respiratory_mucosa1.27826582
54MP0005164_abnormal_response_to1.24550654
55MP0004883_abnormal_blood_vessel1.20653520
56MP0003763_abnormal_thymus_physiology1.17697535
57MP0005058_abnormal_lysosome_morphology1.17684838
58MP0005166_decreased_susceptibility_to1.15818178
59MP0003866_abnormal_defecation1.15457752
60MP0005310_abnormal_salivary_gland1.10837437
61MP0003448_altered_tumor_morphology1.09390539
62MP0005167_abnormal_blood-brain_barrier1.06893174
63MP0009763_increased_sensitivity_to1.05418641
64MP0003183_abnormal_peptide_metabolism1.01380354
65MP0004381_abnormal_hair_follicle0.99724719
66MP0009765_abnormal_xenobiotic_induced0.98271125
67MP0000703_abnormal_thymus_morphology0.97505118
68MP0001663_abnormal_digestive_system0.94301065
69MP0005390_skeleton_phenotype0.93753035
70MP0002332_abnormal_exercise_endurance0.93511705
71MP0005083_abnormal_biliary_tract0.89949438
72MP0003045_fibrosis0.86779319
73MP0003566_abnormal_cell_adhesion0.86324042
74MP0002396_abnormal_hematopoietic_system0.85276589
75MP0000249_abnormal_blood_vessel0.81780335
76MP0004808_abnormal_hematopoietic_stem0.79477386
77MP0001853_heart_inflammation0.78721325
78MP0003453_abnormal_keratinocyte_physiol0.77700375
79MP0003690_abnormal_glial_cell0.77602276
80MP0008874_decreased_physiological_sensi0.75989327
81MP0003878_abnormal_ear_physiology0.72709413
82MP0005377_hearing/vestibular/ear_phenot0.72709413
83MP0004130_abnormal_muscle_cell0.72002933
84MP0003221_abnormal_cardiomyocyte_apopto0.69252739
85MP0000015_abnormal_ear_pigmentation0.67283672
86MP0003806_abnormal_nucleotide_metabolis0.66209390
87MP0003795_abnormal_bone_structure0.65381772
88MP0004484_altered_response_of0.64554609
89MP0005076_abnormal_cell_differentiation0.61450348
90MP0003091_abnormal_cell_migration0.59843708
91MP0006054_spinal_hemorrhage0.59329555
92MP0002138_abnormal_hepatobiliary_system0.59133858
93MP0005535_abnormal_body_temperature0.55177563
94MP0010352_gastrointestinal_tract_polyps0.54917917
95MP0003638_abnormal_response/metabolism_0.54806140
96MP0009840_abnormal_foam_cell0.54056355
97MP0000490_abnormal_crypts_of0.52536706
98MP0003705_abnormal_hypodermis_morpholog0.52194811
99MP0002166_altered_tumor_susceptibility0.50451607
100MP0000604_amyloidosis0.50212260

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.00455828
2Orchitis (HP:0100796)5.83703605
3Myositis (HP:0100614)5.72315601
4Retrobulbar optic neuritis (HP:0100654)5.59028026
5Optic neuritis (HP:0100653)5.59028026
6Abnormality of macrophages (HP:0004311)5.48069736
7Recurrent abscess formation (HP:0002722)5.35993488
8Recurrent bacterial skin infections (HP:0005406)5.33276273
9Stomatitis (HP:0010280)5.28298308
10Prolonged bleeding time (HP:0003010)5.21303487
11Petechiae (HP:0000967)4.48911817
12Elevated erythrocyte sedimentation rate (HP:0003565)4.48057649
13Spontaneous hematomas (HP:0007420)4.31805615
14Recurrent gram-negative bacterial infections (HP:0005420)4.27974565
15Gingival bleeding (HP:0000225)4.26829425
16Keratoconjunctivitis sicca (HP:0001097)4.19677786
17Gastrointestinal infarctions (HP:0005244)4.07324259
18Epistaxis (HP:0000421)4.00759071
19Keratoconjunctivitis (HP:0001096)3.85015136
20Chronic obstructive pulmonary disease (HP:0006510)3.80286525
21Obstructive lung disease (HP:0006536)3.80286525
22Purpura (HP:0000979)3.75425579
23Abnormal platelet volume (HP:0011876)3.74285181
24Increased IgE level (HP:0003212)3.72133567
25Encephalitis (HP:0002383)3.60922530
26Mediastinal lymphadenopathy (HP:0100721)3.52834799
27Episodic fever (HP:0001954)3.51328716
28Urticaria (HP:0001025)3.43208864
29Recurrent fungal infections (HP:0002841)3.42875002
30Vasculitis (HP:0002633)3.40688207
31Recurrent skin infections (HP:0001581)3.38686753
32Meningitis (HP:0001287)3.37512411
33Menorrhagia (HP:0000132)3.34455939
34Arterial thrombosis (HP:0004420)3.31780881
35Gangrene (HP:0100758)3.09687169
36Chest pain (HP:0100749)3.09183332
37Gingivitis (HP:0000230)3.08998015
38Increased mean platelet volume (HP:0011877)3.08742323
39Peritonitis (HP:0002586)3.06980651
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.06860424
41Anorexia (HP:0002039)2.98340915
42Hemoptysis (HP:0002105)2.88215445
43Amyloidosis (HP:0011034)2.84633374
44Increased IgM level (HP:0003496)2.81265915
45Hypochromic microcytic anemia (HP:0004840)2.80623574
46Leukocytosis (HP:0001974)2.80449049
47Pulmonary infiltrates (HP:0002113)2.77878087
48Recurrent cutaneous fungal infections (HP:0011370)2.75513792
49Chronic mucocutaneous candidiasis (HP:0002728)2.75513792
50Pulmonary embolism (HP:0002204)2.73422040
51Hypochromic anemia (HP:0001931)2.55635023
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.54689828
53Cellulitis (HP:0100658)2.54323795
54Impaired platelet aggregation (HP:0003540)2.50594244
55Abnormal platelet function (HP:0011869)2.50594244
56Hepatosplenomegaly (HP:0001433)2.44813412
57Increased serum ferritin (HP:0003281)2.40170482
58Vertigo (HP:0002321)2.36264635
59Inflammation of the large intestine (HP:0002037)2.35689624
60Microcytic anemia (HP:0001935)2.33199762
61Abnormality of iron homeostasis (HP:0011031)2.31413920
62Pustule (HP:0200039)2.27086489
63Glomerulopathy (HP:0100820)2.27011653
64T lymphocytopenia (HP:0005403)2.24591443
65Hypergammaglobulinemia (HP:0010702)2.23406403
66Abnormality of the pleura (HP:0002103)2.23116709
67Abnormality of T cell number (HP:0011839)2.22554343
68Abnormality of the endocardium (HP:0004306)2.21872003
69Gastrointestinal inflammation (HP:0004386)2.21035299
70Granulocytopenia (HP:0001913)2.19944166
71Sepsis (HP:0100806)2.19756015
72Increased cerebral lipofuscin (HP:0011813)2.17554385
73Keratitis (HP:0000491)2.16969499
74Osteomyelitis (HP:0002754)2.16887967
75Joint swelling (HP:0001386)2.11197386
76Abnormality of the peritoneum (HP:0002585)2.10004650
77Bruising susceptibility (HP:0000978)2.09079298
78Acne (HP:0001061)2.07685191
79Recurrent viral infections (HP:0004429)2.05502410
80Polyneuropathy (HP:0001271)1.99188939
81Abnormality of the common coagulation pathway (HP:0010990)1.96776331
82Abnormality of glycosphingolipid metabolism (HP:0004343)1.95654947
83Abnormality of glycolipid metabolism (HP:0010969)1.95654947
84Abnormality of liposaccharide metabolism (HP:0010968)1.95654947
85Thrombophlebitis (HP:0004418)1.94787274
86Eosinophilia (HP:0001880)1.94423315
87Autoimmune thrombocytopenia (HP:0001973)1.92327453
88Loss of speech (HP:0002371)1.92311380
89Premature loss of primary teeth (HP:0006323)1.91869602
90Abnormality of T cells (HP:0002843)1.90896117
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90822437
92Abnormality of transition element cation homeostasis (HP:0011030)1.90399405
93Segmental peripheral demyelination/remyelination (HP:0003481)1.89813353
94Polycythemia (HP:0001901)1.88430878
95Autoimmune hemolytic anemia (HP:0001890)1.87697589
96Abnormality of the pericardium (HP:0001697)1.86546688
97Arthralgia (HP:0002829)1.84572140
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.83055822
99Skin ulcer (HP:0200042)1.79983896
100Acute hepatic failure (HP:0006554)1.78283171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.17068791
2IRAK43.43059237
3MAP2K33.12374272
4BLK2.96689975
5MAP4K12.70836152
6CSK2.54854774
7ERN12.51300184
8TYK22.39027066
9EPHB12.28393964
10ZAP702.25551665
11MAP3K32.25484984
12TAOK12.24663997
13IRAK32.01840730
14GRK62.00430116
15TNK21.99161208
16FES1.91520850
17TXK1.86405247
18FGR1.85240638
19IRAK11.81345602
20MAP3K141.80627212
21MAP3K111.78483168
22HCK1.77651015
23SIK31.70076761
24BTK1.69000188
25PRPF4B1.64667720
26IRAK21.63948972
27JAK31.60393286
28KSR21.57171733
29SYK1.55695081
30TAOK31.53503627
31TAOK21.51983466
32MAP3K11.51313390
33IKBKE1.50899203
34JAK21.48375084
35MATK1.48154557
36TBK11.42491223
37LYN1.32251541
38BMPR21.28304515
39YES11.20187067
40IKBKB1.17530059
41MARK31.08178033
42JAK11.07370113
43CSF1R1.06753635
44MAP3K131.02810075
45PIK3CG1.02337162
46EPHA30.96012509
47MAP3K50.93935069
48MAP3K60.93667153
49PTK2B0.92548434
50MARK20.89195050
51BMX0.88614244
52TEC0.88490066
53LCK0.85771776
54MAP3K20.82177827
55PDK10.82049187
56TESK20.81301408
57PRKD20.80241448
58PDPK10.79374402
59KIT0.71792304
60DAPK20.71790457
61MAP2K40.69273128
62KSR10.63611237
63PTK60.63204214
64CDC42BPA0.62514181
65SGK30.62379130
66SIK20.62006050
67ITK0.60642620
68SIK10.60537989
69RAF10.59866975
70FYN0.58926457
71STK100.56871770
72MAPK120.54850453
73HIPK20.51333525
74STK380.50920943
75DYRK1B0.50572898
76DYRK30.50088702
77RET0.48697514
78TGFBR20.47305960
79WNK10.47123027
80LRRK20.46111192
81PIM10.45855741
82GRK70.45595724
83MAPK70.43896884
84SGK20.41614878
85ACVR1B0.41049922
86STK110.40083958
87MAPKAPK20.38393884
88MAP2K60.35871126
89STK240.35002055
90PRKG20.34760572
91CHUK0.34625848
92MAP3K70.33048782
93NLK0.32631093
94RPS6KL10.32463764
95RPS6KC10.32463764
96PRKCZ0.31208158
97PRKCD0.30880800
98PRKD10.30589747
99FGFR30.29414825
100PRKCQ0.28522207

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.03971357
2Leishmaniasis_Homo sapiens_hsa051402.81350435
3Staphylococcus aureus infection_Homo sapiens_hsa051502.61000513
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37195199
5Malaria_Homo sapiens_hsa051442.22997936
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20188747
7Tuberculosis_Homo sapiens_hsa051522.15571762
8B cell receptor signaling pathway_Homo sapiens_hsa046622.05097378
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.97666216
10Legionellosis_Homo sapiens_hsa051341.96119319
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89883010
12Chemokine signaling pathway_Homo sapiens_hsa040621.82031062
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.75453413
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71027079
15Hematopoietic cell lineage_Homo sapiens_hsa046401.69452851
16Platelet activation_Homo sapiens_hsa046111.69294931
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68115213
18Graft-versus-host disease_Homo sapiens_hsa053321.67894160
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66434223
20Measles_Homo sapiens_hsa051621.62371283
21Acute myeloid leukemia_Homo sapiens_hsa052211.58767520
22TNF signaling pathway_Homo sapiens_hsa046681.57944544
23Allograft rejection_Homo sapiens_hsa053301.52844458
24Influenza A_Homo sapiens_hsa051641.51548102
25Toxoplasmosis_Homo sapiens_hsa051451.45524399
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45172783
27Phagosome_Homo sapiens_hsa041451.42391570
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.38780333
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38265679
30African trypanosomiasis_Homo sapiens_hsa051431.34986730
31Autoimmune thyroid disease_Homo sapiens_hsa053201.32447102
32T cell receptor signaling pathway_Homo sapiens_hsa046601.31901792
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28189820
34Shigellosis_Homo sapiens_hsa051311.28175955
35Pertussis_Homo sapiens_hsa051331.27535894
36Salmonella infection_Homo sapiens_hsa051321.26567753
37Hepatitis B_Homo sapiens_hsa051611.17374661
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16329831
39Rheumatoid arthritis_Homo sapiens_hsa053231.16070684
40Non-small cell lung cancer_Homo sapiens_hsa052231.15448084
41Type I diabetes mellitus_Homo sapiens_hsa049401.12769552
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.12043875
43Pancreatic cancer_Homo sapiens_hsa052121.11837383
44Hepatitis C_Homo sapiens_hsa051601.11243553
45Herpes simplex infection_Homo sapiens_hsa051681.09302798
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08542518
47Primary immunodeficiency_Homo sapiens_hsa053401.07882830
48VEGF signaling pathway_Homo sapiens_hsa043701.05627243
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05050913
50Chronic myeloid leukemia_Homo sapiens_hsa052200.97013185
51Amoebiasis_Homo sapiens_hsa051460.96970751
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94599960
53Viral myocarditis_Homo sapiens_hsa054160.94372387
54Renal cell carcinoma_Homo sapiens_hsa052110.93143878
55Antigen processing and presentation_Homo sapiens_hsa046120.92125493
56Apoptosis_Homo sapiens_hsa042100.90485339
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89543091
58Endocytosis_Homo sapiens_hsa041440.86811290
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.86605795
60Prolactin signaling pathway_Homo sapiens_hsa049170.85055489
61Lysosome_Homo sapiens_hsa041420.82082201
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.81356994
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80607072
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.79908357
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73416847
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.72882657
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72396170
68Other glycan degradation_Homo sapiens_hsa005110.72340398
69FoxO signaling pathway_Homo sapiens_hsa040680.72177965
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.71878835
71Dorso-ventral axis formation_Homo sapiens_hsa043200.71765848
72Notch signaling pathway_Homo sapiens_hsa043300.70833003
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70149362
74Endometrial cancer_Homo sapiens_hsa052130.69420954
75Choline metabolism in cancer_Homo sapiens_hsa052310.68069527
76Asthma_Homo sapiens_hsa053100.65066135
77Collecting duct acid secretion_Homo sapiens_hsa049660.63920467
78Bladder cancer_Homo sapiens_hsa052190.62880742
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.62249006
80HIF-1 signaling pathway_Homo sapiens_hsa040660.62170491
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60896419
82Regulation of autophagy_Homo sapiens_hsa041400.59764500
83Type II diabetes mellitus_Homo sapiens_hsa049300.59198639
84GnRH signaling pathway_Homo sapiens_hsa049120.58492103
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56977284
86Viral carcinogenesis_Homo sapiens_hsa052030.55408029
87Arachidonic acid metabolism_Homo sapiens_hsa005900.55368524
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51689270
89Rap1 signaling pathway_Homo sapiens_hsa040150.51525413
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49757374
91Insulin resistance_Homo sapiens_hsa049310.49399954
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49014395
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48845935
94Complement and coagulation cascades_Homo sapiens_hsa046100.48117279
95MAPK signaling pathway_Homo sapiens_hsa040100.47609173
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46260980
97Epstein-Barr virus infection_Homo sapiens_hsa051690.45160063
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.45060950
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43907118
100Prostate cancer_Homo sapiens_hsa052150.42848823

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »