TREML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.04967207
2regulation of platelet aggregation (GO:0090330)6.22155897
3ribosomal small subunit assembly (GO:0000028)6.09874323
4leukocyte migration involved in inflammatory response (GO:0002523)5.92489456
5positive regulation of gamma-delta T cell activation (GO:0046645)5.77044551
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.59805624
7blood coagulation, intrinsic pathway (GO:0007597)5.49999006
8adenosine receptor signaling pathway (GO:0001973)5.35601983
9positive regulation of B cell differentiation (GO:0045579)5.35457694
10platelet dense granule organization (GO:0060155)5.28595982
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.12410306
12negative regulation of homotypic cell-cell adhesion (GO:0034111)5.08952128
13negative regulation of thymocyte apoptotic process (GO:0070244)5.01053068
14positive regulation of mast cell activation (GO:0033005)4.91632783
15regulation of integrin-mediated signaling pathway (GO:2001044)4.89549109
16lipoxygenase pathway (GO:0019372)4.81783358
17definitive hemopoiesis (GO:0060216)4.78528006
18neutrophil activation (GO:0042119)4.75495525
19positive regulation of endothelial cell differentiation (GO:0045603)4.62964553
20mature B cell differentiation involved in immune response (GO:0002313)4.62009643
21regulation of gamma-delta T cell differentiation (GO:0045586)4.61815929
22megakaryocyte development (GO:0035855)4.59656833
23negative regulation of norepinephrine secretion (GO:0010700)4.57991078
24angiogenesis involved in wound healing (GO:0060055)4.57303990
25negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.47354368
26thrombin receptor signaling pathway (GO:0070493)4.46986511
27negative regulation of heart rate (GO:0010459)4.39139672
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.30610565
29maturation of SSU-rRNA (GO:0030490)4.28313949
30negative regulation of erythrocyte differentiation (GO:0045647)4.25039252
31mature B cell differentiation (GO:0002335)4.22079588
32granulocyte activation (GO:0036230)4.20372864
33platelet degranulation (GO:0002576)4.18451938
34low-density lipoprotein particle remodeling (GO:0034374)4.07543805
35mast cell activation (GO:0045576)4.06314701
36regulation of gamma-delta T cell activation (GO:0046643)4.00754022
37purinergic nucleotide receptor signaling pathway (GO:0035590)4.00037358
38viral transcription (GO:0019083)3.98135677
39positive regulation of cAMP-mediated signaling (GO:0043950)3.86040007
40histamine transport (GO:0051608)3.84363190
41polyamine biosynthetic process (GO:0006596)3.83945109
42regulation of T-helper 1 cell differentiation (GO:0045625)3.79743827
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78949503
44regulation of homotypic cell-cell adhesion (GO:0034110)3.77903153
45regulation of lipoprotein metabolic process (GO:0050746)3.77496401
46Peyers patch development (GO:0048541)3.77305455
47mucosal-associated lymphoid tissue development (GO:0048537)3.77305455
48platelet aggregation (GO:0070527)3.70544630
49platelet formation (GO:0030220)3.70244880
50regulation of MHC class II biosynthetic process (GO:0045346)3.69130147
51secretory granule organization (GO:0033363)3.67560742
52negative regulation of protein localization to cell surface (GO:2000009)3.62695939
53fusion of sperm to egg plasma membrane (GO:0007342)3.62676188
54positive regulation of Rho protein signal transduction (GO:0035025)3.61273322
55translational termination (GO:0006415)3.59862510
56negative regulation of response to food (GO:0032096)3.59180018
57negative regulation of appetite (GO:0032099)3.59180018
58positive regulation of receptor recycling (GO:0001921)3.59078202
59negative regulation of bone mineralization (GO:0030502)3.57916699
60* platelet activation (GO:0030168)3.57757725
61germinal center formation (GO:0002467)3.56977695
62regulation of erythrocyte differentiation (GO:0045646)3.55905954
63negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.54569202
64regulation of Golgi to plasma membrane protein transport (GO:0042996)3.53761634
65purinergic receptor signaling pathway (GO:0035587)3.52588059
66T cell homeostasis (GO:0043029)3.50629926
67ribosomal small subunit biogenesis (GO:0042274)3.49263964
68positive regulation of blood coagulation (GO:0030194)3.49113621
69positive regulation of hemostasis (GO:1900048)3.49113621
70positive regulation of systemic arterial blood pressure (GO:0003084)3.48708162
71G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.47971664
72regulation of macrophage derived foam cell differentiation (GO:0010743)3.45946989
73negative regulation of T cell apoptotic process (GO:0070233)3.37983179
74immunoglobulin mediated immune response (GO:0016064)3.35220349
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34313329
76beta-amyloid metabolic process (GO:0050435)3.32388140
77regulation of mast cell activation (GO:0033003)3.32182187
78regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.31628431
79negative regulation of platelet activation (GO:0010544)3.29668791
80leukocyte degranulation (GO:0043299)3.29506281
81negative regulation of neural precursor cell proliferation (GO:2000178)3.29461351
82positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.29436995
83extracellular fibril organization (GO:0043206)3.27105923
84positive regulation of mast cell activation involved in immune response (GO:0033008)3.26612504
85positive regulation of mast cell degranulation (GO:0043306)3.26612504
86regulation of platelet activation (GO:0010543)3.26396800
87histamine secretion (GO:0001821)3.26231515
88translational elongation (GO:0006414)3.25814904
89regulation of mast cell degranulation (GO:0043304)3.24212849
90positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.23486316
91negative regulation of heart contraction (GO:0045822)3.21944061
92regulation of B cell differentiation (GO:0045577)3.19541452
93termination of G-protein coupled receptor signaling pathway (GO:0038032)3.19384907
94termination of signal transduction (GO:0023021)3.18378177
95B cell activation involved in immune response (GO:0002312)3.16660382
96positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15145316
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14004767
98negative regulation of T-helper cell differentiation (GO:0045623)3.14004767
99positive regulation of coagulation (GO:0050820)3.13372192
100myeloid dendritic cell activation (GO:0001773)3.12704280
101autophagic vacuole fusion (GO:0000046)3.11434797
102regulation of mast cell activation involved in immune response (GO:0033006)3.10101895
103regulation of norepinephrine secretion (GO:0014061)3.09657118
104phagocytosis, engulfment (GO:0006911)3.07462194
105response to muramyl dipeptide (GO:0032495)3.06863511
106endosome to melanosome transport (GO:0035646)3.06778955
107endosome to pigment granule transport (GO:0043485)3.06778955
108regulation of endothelial cell differentiation (GO:0045601)3.06347028
109long-chain fatty acid biosynthetic process (GO:0042759)3.06321144
110telomere maintenance via semi-conservative replication (GO:0032201)3.05639622
111mast cell degranulation (GO:0043303)3.05558607
112mast cell activation involved in immune response (GO:0002279)3.05558607
113neutrophil activation involved in immune response (GO:0002283)3.05546034
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05514033
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04485702
116positive regulation of macrophage differentiation (GO:0045651)3.03146242
117mitochondrial calcium ion transport (GO:0006851)3.02499169
118regulation of cholesterol efflux (GO:0010874)3.00662327
119negative regulation of biomineral tissue development (GO:0070168)2.99667738
120antigen processing and presentation via MHC class Ib (GO:0002475)2.99562409
121purine nucleotide salvage (GO:0032261)2.97783843
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97447423
123response to interferon-beta (GO:0035456)2.97213970
124regulation of integrin activation (GO:0033623)2.96771711
125negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.95839529
126negative regulation of stress fiber assembly (GO:0051497)2.94999737
127protein targeting to ER (GO:0045047)2.94511599
128cotranslational protein targeting to membrane (GO:0006613)2.94437302
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94016337
130negative regulation of calcium ion transport into cytosol (GO:0010523)2.91919469
131regulation of regulatory T cell differentiation (GO:0045589)2.91898175
132pyrimidine nucleoside catabolic process (GO:0046135)2.91250910
133high-density lipoprotein particle remodeling (GO:0034375)2.89533831
134regulation of receptor recycling (GO:0001919)2.88711076
135phospholipid homeostasis (GO:0055091)2.87122594
136regulation of blood coagulation (GO:0030193)2.86754332
137regulation of hemostasis (GO:1900046)2.86754332
138vesicle targeting (GO:0006903)2.86065447
139viral life cycle (GO:0019058)2.85634438
140coenzyme A biosynthetic process (GO:0015937)2.85415958
141fibril organization (GO:0097435)2.85411945
142erythrocyte maturation (GO:0043249)2.85236686
143positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83764839
144B cell mediated immunity (GO:0019724)2.83253699
145cyclooxygenase pathway (GO:0019371)2.83140570
146negative regulation of granulocyte differentiation (GO:0030853)2.82987735
147positive regulation of natural killer cell differentiation (GO:0032825)2.79998817
148NIK/NF-kappaB signaling (GO:0038061)2.79998752
149myeloid cell development (GO:0061515)2.79893496
150myeloid cell activation involved in immune response (GO:0002275)2.79193376
151galactose catabolic process (GO:0019388)2.78967425
152negative regulation of catecholamine secretion (GO:0033604)2.78049466
153establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77922094
154reverse cholesterol transport (GO:0043691)2.77733211
155positive regulation of granulocyte differentiation (GO:0030854)2.76845508
156regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75716682
157positive regulation of B cell mediated immunity (GO:0002714)2.75356842
158positive regulation of immunoglobulin mediated immune response (GO:0002891)2.75356842
159positive regulation of antigen processing and presentation (GO:0002579)2.75044637
160superoxide anion generation (GO:0042554)2.74997558
161cellular biogenic amine biosynthetic process (GO:0042401)2.74872355
162nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74512768
163negative regulation of histone methylation (GO:0031061)2.74445201
164cellular protein complex disassembly (GO:0043624)2.74408299
165protein localization to endoplasmic reticulum (GO:0070972)2.73583206
166DNA strand elongation (GO:0022616)2.73076530
167embryonic hemopoiesis (GO:0035162)2.71746144
168phospholipid scrambling (GO:0017121)2.68884607
169programmed necrotic cell death (GO:0097300)2.68295480
170regulation of interferon-beta biosynthetic process (GO:0045357)2.68240089
171intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.67771430
172regulation of necroptotic process (GO:0060544)2.67696389
173defense response to protozoan (GO:0042832)2.67585938
174regulation of macrophage differentiation (GO:0045649)2.67365255
175protein kinase C signaling (GO:0070528)2.63825169
176opsonization (GO:0008228)2.63624305
177natural killer cell activation involved in immune response (GO:0002323)2.61732420
178DNA strand elongation involved in DNA replication (GO:0006271)2.61460074
179somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61180529
180isotype switching (GO:0045190)2.61180529
181somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61180529
182dendritic cell differentiation (GO:0097028)2.60869776
183homotypic cell-cell adhesion (GO:0034109)2.60518485
184lymphocyte homeostasis (GO:0002260)2.60108634
185positive regulation of erythrocyte differentiation (GO:0045648)2.59396126
186B cell receptor signaling pathway (GO:0050853)2.58857638
187negative regulation of interleukin-8 production (GO:0032717)2.58782115
188DNA topological change (GO:0006265)2.57408624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human6.37898377
2E2F7_22180533_ChIP-Seq_HELA_Human6.29503538
3* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.36437091
4* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.23384979
5* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.15799032
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14099291
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03043877
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.95788908
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86415810
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.85478754
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81275815
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81086530
13* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.79044774
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.51786457
15VDR_21846776_ChIP-Seq_THP-1_Human2.50391426
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49981476
17* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.42214510
18* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.40706266
19SPI1_23547873_ChIP-Seq_NB4_Human2.36337040
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.29089744
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.28303842
22TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.25356588
23* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.21563033
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18887008
25GATA1_19941827_ChIP-Seq_MEL_Mouse2.17821539
26EZH2_22144423_ChIP-Seq_EOC_Human2.10069895
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.08146670
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.05123119
29* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.04792131
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98164559
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.97154439
32GATA2_22383799_ChIP-Seq_G1ME_Mouse1.96207926
33GATA1_19941826_ChIP-Seq_K562_Human1.94517674
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94101091
35VDR_24763502_ChIP-Seq_THP-1_Human1.90842301
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.90708632
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88521521
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83691891
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.81697310
40UTX_26944678_Chip-Seq_JUKART_Human1.79908744
41MYC_22102868_ChIP-Seq_BL_Human1.77343386
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77246943
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77111536
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76535530
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76122341
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.74767163
47HTT_18923047_ChIP-ChIP_STHdh_Human1.73484918
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71998559
49TCF7_22412390_ChIP-Seq_EML_Mouse1.70989615
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.69658657
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68638867
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68581987
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68123288
54* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64351846
55MAF_26560356_Chip-Seq_TH1_Human1.64291651
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63831235
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58830795
58GATA1_19941827_ChIP-Seq_MEL86_Mouse1.58535640
59GBX2_23144817_ChIP-Seq_PC3_Human1.56839556
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52704630
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52066072
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51477383
63MYB_26560356_Chip-Seq_TH1_Human1.49372886
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45925289
65SPI1_23127762_ChIP-Seq_K562_Human1.45598408
66MYB_26560356_Chip-Seq_TH2_Human1.39420026
67GATA1_22025678_ChIP-Seq_K562_Human1.38790417
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33969503
69XRN2_22483619_ChIP-Seq_HELA_Human1.30254444
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.28702540
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28490817
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27502515
73* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25831048
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24328698
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23605233
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23543346
77GATA2_19941826_ChIP-Seq_K562_Human1.22352687
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22336307
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22271033
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21559375
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21375185
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20382170
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19355578
84SPI1_20517297_ChIP-Seq_HL60_Human1.18792675
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18274369
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17718438
87PU_27001747_Chip-Seq_BMDM_Mouse1.17557763
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12245875
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11738458
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11738458
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11308086
92NCOR1_26117541_ChIP-Seq_K562_Human1.11107374
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.09250732
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08336506
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07702979
96VDR_23849224_ChIP-Seq_CD4+_Human1.07620909
97AR_21909140_ChIP-Seq_LNCAP_Human1.07468548
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07248166
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.06603723
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05512540
101TAF15_26573619_Chip-Seq_HEK293_Human1.05447073
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02115825
103GATA3_27048872_Chip-Seq_THYMUS_Human1.01594543
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.01454962
105BCOR_27268052_Chip-Seq_Bcells_Human1.00013124
106BCL6_27268052_Chip-Seq_Bcells_Human0.96517827
107EGR1_19374776_ChIP-ChIP_THP-1_Human0.95694126
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95510876
109* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95492143
110EST1_17652178_ChIP-ChIP_JURKAT_Human0.95476136
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95249095
112MAF_26560356_Chip-Seq_TH2_Human0.94108398
113STAT1_20625510_ChIP-Seq_HELA_Human0.93958870
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93762530
115CIITA_25753668_ChIP-Seq_RAJI_Human0.92962206
116P300_27268052_Chip-Seq_Bcells_Human0.91866062
117SRF_21415370_ChIP-Seq_HL-1_Mouse0.91334407
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89490993
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89297134
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.87712695
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87705586
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87418821
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87011573
124RUNX_20019798_ChIP-Seq_JUKART_Human0.86807873
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86278077
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85009119
127LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84498799
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80573137
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80154206
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80136850
131* GATA3_26560356_Chip-Seq_TH2_Human0.80129253
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79982588
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79808458
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79092789
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78683602
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78473452
137OCT1_27270436_Chip-Seq_PROSTATE_Human0.78258250
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.77884774
139SMRT_27268052_Chip-Seq_Bcells_Human0.77574872
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74961405
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74845039
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74344841
143SOX2_20726797_ChIP-Seq_SW620_Human0.73947728
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73885710
145VDR_24787735_ChIP-Seq_THP-1_Human0.73661120
146TCF4_18268006_ChIP-ChIP_LS174T_Human0.72776399
147JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72725765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005464_abnormal_platelet_physiology4.43003938
2MP0002396_abnormal_hematopoietic_system3.68628070
3MP0000465_gastrointestinal_hemorrhage3.54158907
4MP0006054_spinal_hemorrhage3.33160851
5MP0004808_abnormal_hematopoietic_stem3.26611032
6MP0005397_hematopoietic_system_phenotyp3.15635646
7MP0001545_abnormal_hematopoietic_system3.15635646
8MP0000685_abnormal_immune_system3.13727991
9MP0005671_abnormal_response_to3.12030292
10MP0003724_increased_susceptibility_to2.81747049
11MP0004510_myositis2.77754387
12MP0001835_abnormal_antigen_presentation2.59436143
13MP0005083_abnormal_biliary_tract2.43153707
14MP0004147_increased_porphyrin_level2.38081153
15MP0009278_abnormal_bone_marrow2.35893247
16MP0003303_peritoneal_inflammation2.11095782
17MP0001800_abnormal_humoral_immune2.00774918
18MP0002419_abnormal_innate_immunity1.94067046
19MP0000230_abnormal_systemic_arterial1.93991863
20* MP0002398_abnormal_bone_marrow1.93436560
21MP0003567_abnormal_fetal_cardiomyocyte1.92907854
22MP0002736_abnormal_nociception_after1.89945850
23MP0002148_abnormal_hypersensitivity_rea1.89783331
24MP0004084_abnormal_cardiac_muscle1.89382485
25MP0005000_abnormal_immune_tolerance1.86805861
26MP0000689_abnormal_spleen_morphology1.85416577
27MP0003436_decreased_susceptibility_to1.85174290
28MP0005025_abnormal_response_to1.81359678
29MP0008057_abnormal_DNA_replication1.80390407
30MP0003763_abnormal_thymus_physiology1.80234732
31MP0002452_abnormal_antigen_presenting1.79574452
32MP0002722_abnormal_immune_system1.79100898
33* MP0002723_abnormal_immune_serum1.77376314
34MP0003638_abnormal_response/metabolism_1.72734801
35MP0003656_abnormal_erythrocyte_physiolo1.72727511
36MP0002420_abnormal_adaptive_immunity1.70968471
37MP0001853_heart_inflammation1.68891513
38MP0001819_abnormal_immune_cell1.67836888
39MP0005084_abnormal_gallbladder_morpholo1.67286415
40MP0002405_respiratory_system_inflammati1.67081100
41MP0000343_altered_response_to1.62878695
42MP0009785_altered_susceptibility_to1.62735811
43MP0001879_abnormal_lymphatic_vessel1.59758430
44MP0005174_abnormal_tail_pigmentation1.58649159
45MP0003879_abnormal_hair_cell1.54979126
46MP0010155_abnormal_intestine_physiology1.52267100
47MP0000490_abnormal_crypts_of1.48158686
48* MP0002429_abnormal_blood_cell1.47883966
49MP0002638_abnormal_pupillary_reflex1.47406515
50MP0005410_abnormal_fertilization1.46875200
51MP0005075_abnormal_melanosome_morpholog1.44611191
52MP0000716_abnormal_immune_system1.44335516
53MP0009333_abnormal_splenocyte_physiolog1.42692553
54MP0001873_stomach_inflammation1.42664329
55MP0008872_abnormal_physiological_respon1.42487947
56MP0004036_abnormal_muscle_relaxation1.37996046
57MP0009764_decreased_sensitivity_to1.32517478
58MP0003566_abnormal_cell_adhesion1.32409438
59MP0003300_gastrointestinal_ulcer1.31497846
60MP0009379_abnormal_foot_pigmentation1.30939563
61MP0008004_abnormal_stomach_pH1.30411986
62MP0001790_abnormal_immune_system1.29459139
63MP0005387_immune_system_phenotype1.29459139
64MP0003866_abnormal_defecation1.27133072
65MP0006082_CNS_inflammation1.25493382
66MP0003828_pulmonary_edema1.25351912
67MP0005647_abnormal_sex_gland1.23622838
68MP0005167_abnormal_blood-brain_barrier1.23385987
69MP0008469_abnormal_protein_level1.21738075
70MP0010094_abnormal_chromosome_stability1.21583052
71MP0003172_abnormal_lysosome_physiology1.20490948
72MP0001968_abnormal_touch/_nociception1.18749947
73* MP0001845_abnormal_inflammatory_respons1.16481567
74MP0000703_abnormal_thymus_morphology1.16191645
75MP0004947_skin_inflammation1.15795292
76MP0003191_abnormal_cellular_cholesterol1.15006964
77MP0002733_abnormal_thermal_nociception1.11562733
78MP0004264_abnormal_extraembryonic_tissu1.11523850
79MP0010368_abnormal_lymphatic_system1.08351472
80MP0003111_abnormal_nucleus_morphology1.05921884
81MP0003075_altered_response_to1.04736627
82MP0005409_darkened_coat_color1.03816420
83MP0002095_abnormal_skin_pigmentation1.02936051
84MP0005646_abnormal_pituitary_gland1.02917293
85MP0001663_abnormal_digestive_system1.02705397
86MP0002998_abnormal_bone_remodeling1.00826982
87MP0003279_aneurysm0.96225762
88MP0002166_altered_tumor_susceptibility0.93283849
89MP0003077_abnormal_cell_cycle0.93189080
90MP0009763_increased_sensitivity_to0.89658581
91MP0001533_abnormal_skeleton_physiology0.89187255
92MP0000767_abnormal_smooth_muscle0.88970160
93MP0000015_abnormal_ear_pigmentation0.88901429
94MP0005381_digestive/alimentary_phenotyp0.88424716
95MP0003943_abnormal_hepatobiliary_system0.88231024
96* MP0009642_abnormal_blood_homeostasis0.88151412
97MP0009765_abnormal_xenobiotic_induced0.88005021
98MP0002089_abnormal_postnatal_growth/wei0.87914970
99MP0002876_abnormal_thyroid_physiology0.86930271
100MP0000313_abnormal_cell_death0.86504850
101MP0001191_abnormal_skin_condition0.84296971
102MP0005165_increased_susceptibility_to0.83425950
103MP0005023_abnormal_wound_healing0.83081513
104MP0003448_altered_tumor_morphology0.82475377
105MP0001851_eye_inflammation0.79587070
106MP0000249_abnormal_blood_vessel0.79357756
107MP0005058_abnormal_lysosome_morphology0.79219097
108MP0001765_abnormal_ion_homeostasis0.78395709
109MP0001970_abnormal_pain_threshold0.76497855
110MP0002006_tumorigenesis0.76216746
111MP0004215_abnormal_myocardial_fiber0.75190756
112MP0008260_abnormal_autophagy0.75178471
113MP0010329_abnormal_lipoprotein_level0.74632070
114MP0003453_abnormal_keratinocyte_physiol0.73618812
115MP0008775_abnormal_heart_ventricle0.73590764
116MP0001664_abnormal_digestion0.73274248
117MP0002877_abnormal_melanocyte_morpholog0.72468976
118MP0004883_abnormal_blood_vessel0.72066949
119MP0002019_abnormal_tumor_incidence0.71549445
120MP0005360_urolithiasis0.70785310
121MP0002972_abnormal_cardiac_muscle0.70744547
122MP0000858_altered_metastatic_potential0.69823860
123MP0010352_gastrointestinal_tract_polyps0.69802156
124MP0008058_abnormal_DNA_repair0.69794621
125MP0003183_abnormal_peptide_metabolism0.69453388
126MP0004484_altered_response_of0.68595228
127MP0002132_abnormal_respiratory_system0.68538064
128MP0005535_abnormal_body_temperature0.68296884
129MP0003011_delayed_dark_adaptation0.67377908
130MP0001544_abnormal_cardiovascular_syste0.67266966
131MP0005385_cardiovascular_system_phenoty0.67266966
132MP0002118_abnormal_lipid_homeostasis0.66252042
133MP0004130_abnormal_muscle_cell0.66235263
134MP0008874_decreased_physiological_sensi0.64930736
135MP0006138_congestive_heart_failure0.63838611
136MP0005666_abnormal_adipose_tissue0.62761276
137MP0005501_abnormal_skin_physiology0.61496639

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.27426100
2Petechiae (HP:0000967)6.97074525
3Increased mean platelet volume (HP:0011877)6.47852269
4Purpura (HP:0000979)6.28423685
5Abnormal platelet volume (HP:0011876)6.25770026
6Hyperlipoproteinemia (HP:0010980)5.94746575
7Menorrhagia (HP:0000132)5.89080290
8Epistaxis (HP:0000421)4.99929108
9Gingival bleeding (HP:0000225)4.81057265
10Acanthocytosis (HP:0001927)4.80048692
11Spontaneous hematomas (HP:0007420)4.67339156
12Abnormality of the heme biosynthetic pathway (HP:0010472)4.40602679
13Impaired platelet aggregation (HP:0003540)4.28847162
14Abnormal platelet function (HP:0011869)4.28847162
15Recurrent abscess formation (HP:0002722)4.00461562
16Poikilocytosis (HP:0004447)3.98735744
17Recurrent bacterial skin infections (HP:0005406)3.80655489
18Thrombocytosis (HP:0001894)3.72007606
19Conjunctival telangiectasia (HP:0000524)3.68234329
20Abnormal number of erythroid precursors (HP:0012131)3.53308815
21Hypobetalipoproteinemia (HP:0003563)3.50523560
22Dyschromatopsia (HP:0007641)3.49727317
23Abnormality of cells of the erythroid lineage (HP:0012130)3.30775863
24Abnormality of the vasculature of the conjunctiva (HP:0008054)3.28218842
25Abnormal pupillary function (HP:0007686)3.23573148
26Increased density of long bones (HP:0006392)3.13714445
27Reticulocytopenia (HP:0001896)3.13046548
28Interstitial pulmonary disease (HP:0006530)3.10397375
29Dry hair (HP:0011359)3.10117265
30Aplastic anemia (HP:0001915)3.08912246
31Elevated erythrocyte sedimentation rate (HP:0003565)3.03918029
32Paralysis (HP:0003470)2.98394337
33Recurrent viral infections (HP:0004429)2.97221683
34Colitis (HP:0002583)2.90846939
35Cellulitis (HP:0100658)2.89169199
36Stomatitis (HP:0010280)2.82326586
37Hepatosplenomegaly (HP:0001433)2.81901866
38Abnormality of macrophages (HP:0004311)2.58743840
39Anhidrosis (HP:0000970)2.56696036
40Amaurosis fugax (HP:0100576)2.56126630
41Increased IgM level (HP:0003496)2.52627805
42Increased serum ferritin (HP:0003281)2.51722706
43Joint hemorrhage (HP:0005261)2.45936253
44Poikiloderma (HP:0001029)2.45547172
45Joint swelling (HP:0001386)2.44705635
46Inflammation of the large intestine (HP:0002037)2.42152478
47Increased hepatocellular lipid droplets (HP:0006565)2.42143341
48Panhypogammaglobulinemia (HP:0003139)2.41944821
49Xanthomatosis (HP:0000991)2.40622439
50Hypoplasia of the thymus (HP:0000778)2.39198825
51Nonimmune hydrops fetalis (HP:0001790)2.36818185
52Recurrent skin infections (HP:0001581)2.35151571
53IgM deficiency (HP:0002850)2.33613040
54Lipid accumulation in hepatocytes (HP:0006561)2.32779817
55Abnormality of reticulocytes (HP:0004312)2.31280664
56Gastrointestinal inflammation (HP:0004386)2.30986246
57Obstructive lung disease (HP:0006536)2.29549223
58Chronic obstructive pulmonary disease (HP:0006510)2.29549223
59Recurrent fungal infections (HP:0002841)2.28479063
60Myositis (HP:0100614)2.27706009
61Chronic otitis media (HP:0000389)2.25897800
62Akinesia (HP:0002304)2.25086908
63Agammaglobulinemia (HP:0004432)2.23128138
64Mediastinal lymphadenopathy (HP:0100721)2.22922760
65Agnosia (HP:0010524)2.22267825
66Pallor (HP:0000980)2.22105021
67Upper limb muscle weakness (HP:0003484)2.21791220
68Bruising susceptibility (HP:0000978)2.21676739
69Microvesicular hepatic steatosis (HP:0001414)2.20994995
70Exertional dyspnea (HP:0002875)2.20210360
71Global brain atrophy (HP:0002283)2.19573202
72Type 2 muscle fiber atrophy (HP:0003554)2.17652344
73Encephalitis (HP:0002383)2.16793064
74Increased IgE level (HP:0003212)2.14338705
75Entropion (HP:0000621)2.11889325
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11587653
77Tinnitus (HP:0000360)2.10001781
78Dysphonia (HP:0001618)2.09389496
79Abnormality of the prostate (HP:0008775)2.08657180
80Episodic fever (HP:0001954)2.06312826
81Fatigue (HP:0012378)2.04031777
82Ventricular fibrillation (HP:0001663)2.03662076
83Thyroiditis (HP:0100646)2.03336923
84Myelodysplasia (HP:0002863)2.03106715
85Abnormality of lateral ventricle (HP:0030047)2.02592678
86Abnormality of iron homeostasis (HP:0011031)2.01169413
87Neurodegeneration (HP:0002180)2.00645738
88Arterial thrombosis (HP:0004420)2.00265220
89Eczematoid dermatitis (HP:0000976)1.99569629
90Papilledema (HP:0001085)1.98076140
91Nausea (HP:0002018)1.97258296
92Tongue fasciculations (HP:0001308)1.96264542
93Pancytopenia (HP:0001876)1.95750882
94Decreased central vision (HP:0007663)1.95706746
95Male infertility (HP:0003251)1.94827654
96Abnormality of transition element cation homeostasis (HP:0011030)1.94141596
97Papillary thyroid carcinoma (HP:0002895)1.94036358
98Leukocytosis (HP:0001974)1.93905445
99Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93731799
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93731799
101Generalized aminoaciduria (HP:0002909)1.93578920
102Colon cancer (HP:0003003)1.90689898
103Muscle fiber atrophy (HP:0100295)1.88819240
104Vacuolated lymphocytes (HP:0001922)1.88643949
105Basal ganglia calcification (HP:0002135)1.88492337
106Reticulocytosis (HP:0001923)1.85287355
107Tetraparesis (HP:0002273)1.85279013
108Hyperthyroidism (HP:0000836)1.83551688
109Recurrent gram-negative bacterial infections (HP:0005420)1.82661577
110Dysautonomia (HP:0002459)1.81876303
111Myocardial infarction (HP:0001658)1.81567018
112Periodontitis (HP:0000704)1.81433373
113Reduced antithrombin III activity (HP:0001976)1.79755525
114Urticaria (HP:0001025)1.78834590
115Asplenia (HP:0001746)1.77407225
116Gastrointestinal stroma tumor (HP:0100723)1.75923649
117Abnormality of the basal ganglia (HP:0002134)1.74915708
118Autoimmune thrombocytopenia (HP:0001973)1.72781967
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71991558
120Muscle fibrillation (HP:0010546)1.71880820
121Sepsis (HP:0100806)1.71810883
122Abnormality of the common coagulation pathway (HP:0010990)1.71694914
123Increased intramyocellular lipid droplets (HP:0012240)1.70810261
124Dysostosis multiplex (HP:0000943)1.70724563
125Distal lower limb amyotrophy (HP:0008944)1.69489876
126Chest pain (HP:0100749)1.69079479
127Vertigo (HP:0002321)1.68778282
128Autoimmune hemolytic anemia (HP:0001890)1.68228470
129Thyroid-stimulating hormone excess (HP:0002925)1.67498374
130Spontaneous abortion (HP:0005268)1.66804939
131Ragged-red muscle fibers (HP:0003200)1.66764235
132Macrocytic anemia (HP:0001972)1.66508900
133Polycythemia (HP:0001901)1.66449810
134Recurrent bronchitis (HP:0002837)1.65592532
135Lymphoma (HP:0002665)1.65310498
136Abnormal auditory evoked potentials (HP:0006958)1.65058639
137Chronic mucocutaneous candidiasis (HP:0002728)1.64541096
138Recurrent cutaneous fungal infections (HP:0011370)1.64541096
139Diplopia (HP:0000651)1.61347262
140Abnormality of binocular vision (HP:0011514)1.61347262
141Hypophosphatemic rickets (HP:0004912)1.59081629
1423-Methylglutaconic aciduria (HP:0003535)1.55595907
143Abnormal ciliary motility (HP:0012262)1.55383730
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.54856569
145Uterine leiomyosarcoma (HP:0002891)1.54150466
146Leiomyosarcoma (HP:0100243)1.54150466
147Biliary tract neoplasm (HP:0100574)1.51834830
148Transitional cell carcinoma of the bladder (HP:0006740)1.49614624
149Mucosal telangiectasiae (HP:0100579)1.46049383
150Polyphagia (HP:0002591)1.45531995
151Thrombophlebitis (HP:0004418)1.43940079
152Arthropathy (HP:0003040)1.43564411
153Testicular neoplasm (HP:0010788)1.40542193
154Cerebral ischemia (HP:0002637)1.36067698
155Bladder carcinoma (HP:0002862)1.35285154
156Bladder neoplasm (HP:0009725)1.35285154
157Hypertriglyceridemia (HP:0002155)1.33924269
158Granulocytopenia (HP:0001913)1.33261300
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.32520077
160Pulmonary embolism (HP:0002204)1.32089467
161Mitral stenosis (HP:0001718)1.31862084
162Arthralgia (HP:0002829)1.30587101
163Infertility (HP:0000789)1.29407362
164Eosinophilia (HP:0001880)1.28381636
165Lower limb amyotrophy (HP:0007210)1.28142176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.91357053
2MST44.60182682
3BMX4.25018876
4MAP4K13.94254012
5MYLK3.61409299
6MAP3K63.30816040
7TIE13.21558075
8MAP2K33.18239106
9EIF2AK13.16000762
10TXK3.09155278
11BLK3.01077972
12NME22.83520299
13TBK12.53342794
14KIT2.42002240
15SIK32.37959436
16SYK2.27415130
17ZAP702.21615279
18GRK62.18011792
19GRK52.13930468
20BTK2.12432780
21JAK32.02179940
22IKBKE2.01545008
23FGR1.94233742
24TEC1.88343223
25BMPR21.86636722
26MAP3K141.67498881
27MATK1.62364928
28KDR1.61637145
29CSF1R1.50982860
30LYN1.48495735
31SIK21.48377950
32IKBKB1.46982036
33TNK21.46911960
34SIK11.41164038
35STK31.37756305
36PIM11.32106262
37TGFBR21.29197272
38MAPKAPK31.28952385
39CDC71.27690912
40PAK11.21542650
41CCNB11.19112615
42TGFBR11.16462772
43YES11.16275955
44LMTK21.07266913
45DAPK31.06704358
46LCK1.05215143
47CDK191.05023206
48MAP3K51.04938490
49FES1.04929156
50PLK21.01924384
51ACVR1B1.00192535
52HCK0.98692190
53MAP2K60.98595951
54STK100.98211291
55MARK30.97379254
56RPS6KA40.94797826
57MKNK10.94073033
58ITK0.94000224
59PTK2B0.91634390
60IRAK40.89168105
61TRIB30.88252539
62IRAK10.87947717
63TAOK10.87935867
64TAOK20.87469531
65EPHA30.86461058
66PIK3CG0.85752828
67ERN10.85523084
68WEE10.83788849
69CLK10.83731321
70RPS6KB20.82817581
71TYK20.81755617
72PASK0.81379610
73TNIK0.80187144
74DAPK20.78817388
75ADRBK10.78677672
76NEK20.77496244
77PDK10.77322537
78RIPK10.77227536
79MAP3K120.76836703
80DYRK30.76655857
81ARAF0.75114641
82LRRK20.74679447
83PNCK0.73308894
84ERBB20.72652584
85JAK20.71983446
86TESK20.69764535
87CDK60.68768791
88MAPK120.68008686
89PRKD10.67629207
90MAPKAPK50.67115765
91PIM20.66821710
92HIPK20.66000257
93EPHB10.59939708
94CHUK0.59894535
95CDK80.59816376
96DYRK1B0.59368273
97TLK10.58281437
98TRIM280.57359903
99PKN10.57313765
100FER0.57259126
101EPHB20.55289059
102VRK10.55212445
103ADRBK20.54724224
104MAP3K110.54149001
105FYN0.53718424
106PDGFRB0.53487340
107MAP2K70.51848543
108STK160.50896898
109TAOK30.50561710
110PKN20.49705383
111PRKACG0.49042873
112MAP3K30.48855034
113STK240.48506359
114SCYL20.48066745
115CAMKK20.47169834
116EEF2K0.46384964
117MAP2K10.43856057
118MUSK0.43435632
119BCKDK0.43077942
120CSK0.43064399
121ILK0.42001883
122FLT30.41689519
123CDK70.40174928
124JAK10.39343795
125MAPK110.39022818
126PAK40.38002580
127PDPK10.37232236
128DAPK10.36792680
129MAP3K130.36749120
130PINK10.36150305
131MINK10.35652413
132MAPK40.35562663
133PRKCQ0.35423987
134ABL10.35159721
135IRAK20.34531264
136PRKG10.34510355
137CAMK10.33751406
138AURKB0.33218535
139PRKCD0.33218328
140RET0.32621843
141PAK30.32176629
142BMPR1B0.31577758
143NUAK10.31053386
144STK40.30323404
145PRKG20.29932723
146MAPK130.29791169
147IRAK30.29725547
148ABL20.29323110
149MAP3K10.29155785
150PLK10.28399523
151PRKCB0.28146920
152NLK0.26901521
153SRC0.25501010
154PRKCA0.24074295
155ROCK10.23724114
156SGK20.22837222

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.65585886
2DNA replication_Homo sapiens_hsa030303.59260572
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34999914
4Hematopoietic cell lineage_Homo sapiens_hsa046403.22811060
5Ribosome_Homo sapiens_hsa030103.21002006
6Homologous recombination_Homo sapiens_hsa034402.81402225
7Mismatch repair_Homo sapiens_hsa034302.56044152
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.16199502
9Leishmaniasis_Homo sapiens_hsa051402.11058512
10B cell receptor signaling pathway_Homo sapiens_hsa046622.08003876
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02389888
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01925229
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90802362
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.90260871
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78727299
16Gap junction_Homo sapiens_hsa045401.75836139
17Nitrogen metabolism_Homo sapiens_hsa009101.70714355
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.68750853
19ECM-receptor interaction_Homo sapiens_hsa045121.57834410
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.56684248
21Measles_Homo sapiens_hsa051621.53881664
22Collecting duct acid secretion_Homo sapiens_hsa049661.53071244
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53069140
24Staphylococcus aureus infection_Homo sapiens_hsa051501.52042710
25Nucleotide excision repair_Homo sapiens_hsa034201.51875603
26Serotonergic synapse_Homo sapiens_hsa047261.50668647
27Osteoclast differentiation_Homo sapiens_hsa043801.49562005
28Primary immunodeficiency_Homo sapiens_hsa053401.48809504
29Pertussis_Homo sapiens_hsa051331.46261473
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45380529
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.41795147
32Endocytosis_Homo sapiens_hsa041441.37419171
33Base excision repair_Homo sapiens_hsa034101.32344142
34Systemic lupus erythematosus_Homo sapiens_hsa053221.29748793
35Legionellosis_Homo sapiens_hsa051341.29411839
36Malaria_Homo sapiens_hsa051441.27505584
37Small cell lung cancer_Homo sapiens_hsa052221.24348050
38Alcoholism_Homo sapiens_hsa050341.24165566
39Pyrimidine metabolism_Homo sapiens_hsa002401.21802445
40Other glycan degradation_Homo sapiens_hsa005111.21254250
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20558231
42Chemokine signaling pathway_Homo sapiens_hsa040621.18660958
43Galactose metabolism_Homo sapiens_hsa000521.18166595
44One carbon pool by folate_Homo sapiens_hsa006701.17747310
45Phagosome_Homo sapiens_hsa041451.17220212
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16975248
47Apoptosis_Homo sapiens_hsa042101.16967089
48Chronic myeloid leukemia_Homo sapiens_hsa052201.16477784
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16090970
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13707291
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13532083
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11254353
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.11099153
54Pancreatic secretion_Homo sapiens_hsa049721.10490218
55Shigellosis_Homo sapiens_hsa051311.07724585
56Glycerolipid metabolism_Homo sapiens_hsa005611.07649085
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07043772
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.06035928
59Herpes simplex infection_Homo sapiens_hsa051681.05858973
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05110480
61Acute myeloid leukemia_Homo sapiens_hsa052211.04412684
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.03539173
63Cell cycle_Homo sapiens_hsa041100.97954541
64Long-term depression_Homo sapiens_hsa047300.95124549
65TNF signaling pathway_Homo sapiens_hsa046680.93329112
66Graft-versus-host disease_Homo sapiens_hsa053320.92786470
67Pentose phosphate pathway_Homo sapiens_hsa000300.92574278
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.91972011
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91416258
70Sulfur metabolism_Homo sapiens_hsa009200.90200139
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89560372
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87993131
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84762108
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83494702
75Pancreatic cancer_Homo sapiens_hsa052120.81010516
76Complement and coagulation cascades_Homo sapiens_hsa046100.80124148
77Hepatitis B_Homo sapiens_hsa051610.80056416
78Allograft rejection_Homo sapiens_hsa053300.79897648
79Toxoplasmosis_Homo sapiens_hsa051450.79230843
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79204276
81Morphine addiction_Homo sapiens_hsa050320.78800598
82Linoleic acid metabolism_Homo sapiens_hsa005910.78777252
83Olfactory transduction_Homo sapiens_hsa047400.77810429
84Tuberculosis_Homo sapiens_hsa051520.76041036
85Circadian entrainment_Homo sapiens_hsa047130.75374021
86Choline metabolism in cancer_Homo sapiens_hsa052310.75006064
87ABC transporters_Homo sapiens_hsa020100.74348431
88Autoimmune thyroid disease_Homo sapiens_hsa053200.74003581
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73632388
90Folate biosynthesis_Homo sapiens_hsa007900.73191534
91Fanconi anemia pathway_Homo sapiens_hsa034600.72970991
92Influenza A_Homo sapiens_hsa051640.72650882
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71720993
94Antigen processing and presentation_Homo sapiens_hsa046120.70963271
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70925997
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70041294
97Renin-angiotensin system_Homo sapiens_hsa046140.69999329
98Glutathione metabolism_Homo sapiens_hsa004800.69512524
99RNA degradation_Homo sapiens_hsa030180.69361703
100Non-small cell lung cancer_Homo sapiens_hsa052230.68701711
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.67194273
102Spliceosome_Homo sapiens_hsa030400.66524326
103Endometrial cancer_Homo sapiens_hsa052130.62400044
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.62190896
105Ras signaling pathway_Homo sapiens_hsa040140.61798609
106Prolactin signaling pathway_Homo sapiens_hsa049170.61651391
107Fatty acid elongation_Homo sapiens_hsa000620.59884220
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59807650
109Purine metabolism_Homo sapiens_hsa002300.58788711
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58548809
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.56723730
112Epstein-Barr virus infection_Homo sapiens_hsa051690.56259120
113Amoebiasis_Homo sapiens_hsa051460.54240953
114N-Glycan biosynthesis_Homo sapiens_hsa005100.51544148
115RNA polymerase_Homo sapiens_hsa030200.50568635
116Viral myocarditis_Homo sapiens_hsa054160.50274135
117VEGF signaling pathway_Homo sapiens_hsa043700.49813735
118Calcium signaling pathway_Homo sapiens_hsa040200.49805295
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48701312
120Salmonella infection_Homo sapiens_hsa051320.47360967
121p53 signaling pathway_Homo sapiens_hsa041150.46558770
122Dilated cardiomyopathy_Homo sapiens_hsa054140.45710218
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45386687
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44894006
125Vitamin digestion and absorption_Homo sapiens_hsa049770.44726661
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44591296
127Cholinergic synapse_Homo sapiens_hsa047250.44420321
128Gastric acid secretion_Homo sapiens_hsa049710.44364589
129Starch and sucrose metabolism_Homo sapiens_hsa005000.44141052
130GABAergic synapse_Homo sapiens_hsa047270.44029734
131Fat digestion and absorption_Homo sapiens_hsa049750.43899276
132Renal cell carcinoma_Homo sapiens_hsa052110.42789426
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.41889671
134Renin secretion_Homo sapiens_hsa049240.41572809
135Arachidonic acid metabolism_Homo sapiens_hsa005900.40982041
136Glioma_Homo sapiens_hsa052140.40165329
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37690073
138Rap1 signaling pathway_Homo sapiens_hsa040150.37525642
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37523961
140Proteasome_Homo sapiens_hsa030500.37391248
141HTLV-I infection_Homo sapiens_hsa051660.37106537
142Arginine biosynthesis_Homo sapiens_hsa002200.37094118
143Asthma_Homo sapiens_hsa053100.36434603
144T cell receptor signaling pathway_Homo sapiens_hsa046600.32896485
145Rheumatoid arthritis_Homo sapiens_hsa053230.32439790
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32368566
147Hepatitis C_Homo sapiens_hsa051600.30947784
148Viral carcinogenesis_Homo sapiens_hsa052030.28933761
149Phenylalanine metabolism_Homo sapiens_hsa003600.26850846
150Focal adhesion_Homo sapiens_hsa045100.25586115
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23921980

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