TRDV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)9.81015615
2negative thymic T cell selection (GO:0045060)8.90917867
3positive regulation of gamma-delta T cell activation (GO:0046645)8.49061778
4positive T cell selection (GO:0043368)8.07207568
5positive thymic T cell selection (GO:0045059)7.54686825
6thymic T cell selection (GO:0045061)7.52997018
7T cell selection (GO:0045058)7.30541098
8regulation of gamma-delta T cell differentiation (GO:0045586)7.24707066
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.23705529
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.23705529
11negative regulation of cell killing (GO:0031342)7.19694072
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.19694072
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.95499655
14regulation of T cell tolerance induction (GO:0002664)6.78896111
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.77007985
16regulation of isotype switching to IgG isotypes (GO:0048302)6.72773116
17interferon-gamma production (GO:0032609)6.48689039
18regulation of gamma-delta T cell activation (GO:0046643)6.48475484
19T cell receptor signaling pathway (GO:0050852)6.17550599
20activated T cell proliferation (GO:0050798)6.15430733
21antigen processing and presentation of endogenous antigen (GO:0019883)5.96580681
22T cell migration (GO:0072678)5.82818497
23response to interleukin-15 (GO:0070672)5.81294273
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.74336470
25T cell costimulation (GO:0031295)5.68090087
26cellular response to interleukin-15 (GO:0071350)5.65266565
27lymphocyte costimulation (GO:0031294)5.58412357
28positive regulation of tolerance induction (GO:0002645)5.56761954
29leukocyte aggregation (GO:0070486)5.50989090
30antigen receptor-mediated signaling pathway (GO:0050851)4.98884891
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.86814323
32regulation of tolerance induction (GO:0002643)4.85342891
33positive regulation of alpha-beta T cell proliferation (GO:0046641)4.84959505
34regulation of alpha-beta T cell proliferation (GO:0046640)4.84470646
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.83355650
36negative regulation of T-helper cell differentiation (GO:0045623)4.83355650
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.82046933
38positive regulation of natural killer cell mediated immunity (GO:0002717)4.82046933
39negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.80428142
40regulation of T cell receptor signaling pathway (GO:0050856)4.71841649
41regulation of natural killer cell mediated immunity (GO:0002715)4.68065474
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.68065474
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.58753655
44regulation of B cell receptor signaling pathway (GO:0050855)4.54434055
45positive regulation of interleukin-2 production (GO:0032743)4.44378533
46mast cell activation (GO:0045576)4.37314898
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.11314911
48V(D)J recombination (GO:0033151)4.10715039
49positive regulation of isotype switching (GO:0045830)4.10654968
50T cell differentiation (GO:0030217)3.97812665
51negative regulation of T cell mediated immunity (GO:0002710)3.96725067
52signal complex assembly (GO:0007172)3.93045990
53regulation of B cell differentiation (GO:0045577)3.92341807
54regulation of isotype switching (GO:0045191)3.90220146
55positive regulation of B cell differentiation (GO:0045579)3.89608481
56regulation of regulatory T cell differentiation (GO:0045589)3.88495735
57regulation of defense response to virus by virus (GO:0050690)3.81789309
58alpha-beta T cell differentiation (GO:0046632)3.81411635
59alpha-beta T cell activation (GO:0046631)3.81404373
60negative regulation of T cell receptor signaling pathway (GO:0050860)3.80877567
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76366727
62negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.75900179
63negative regulation of adaptive immune response (GO:0002820)3.75656222
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.74475348
65positive regulation of immune response to tumor cell (GO:0002839)3.73599935
66regulation of immune response to tumor cell (GO:0002837)3.73599935
67regulation of response to tumor cell (GO:0002834)3.73599935
68positive regulation of response to tumor cell (GO:0002836)3.73599935
69T cell activation (GO:0042110)3.69050233
70Peyers patch development (GO:0048541)3.68532933
71mucosal-associated lymphoid tissue development (GO:0048537)3.68532933
72positive regulation of B cell mediated immunity (GO:0002714)3.64812372
73positive regulation of immunoglobulin mediated immune response (GO:0002891)3.64812372
74negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.60745016
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.60353367
76sequestering of actin monomers (GO:0042989)3.60002281
77leukocyte cell-cell adhesion (GO:0007159)3.58261789
78negative regulation of leukocyte mediated immunity (GO:0002704)3.54401341
79response to interleukin-4 (GO:0070670)3.53767453
80positive regulation of DNA recombination (GO:0045911)3.52386464
81regulation of immunoglobulin mediated immune response (GO:0002889)3.51845747
82regulation of leukocyte mediated cytotoxicity (GO:0001910)3.49021487
83positive regulation of humoral immune response (GO:0002922)3.47512733
84immune response-activating cell surface receptor signaling pathway (GO:0002429)3.46621549
85heterotypic cell-cell adhesion (GO:0034113)3.44373545
86B cell receptor signaling pathway (GO:0050853)3.43937556
87ribosomal small subunit assembly (GO:0000028)3.43260889
88positive regulation of calcium-mediated signaling (GO:0050850)3.41228098
89negative regulation of alpha-beta T cell activation (GO:0046636)3.40295110
90regulation of B cell mediated immunity (GO:0002712)3.38236931
91positive regulation of interleukin-4 production (GO:0032753)3.38122331
92T cell proliferation (GO:0042098)3.34522011
93regulation of alpha-beta T cell activation (GO:0046634)3.34373650
94mast cell degranulation (GO:0043303)3.32176458
95mast cell activation involved in immune response (GO:0002279)3.32176458
96viral transcription (GO:0019083)3.31055772
97regulation of interleukin-2 production (GO:0032663)3.30912478
98lymphocyte migration (GO:0072676)3.30326063
99cellular response to interleukin-4 (GO:0071353)3.28480528
100regulation of interleukin-4 production (GO:0032673)3.28462312
101positive regulation of cell killing (GO:0031343)3.28203093
102negative regulation of lymphocyte mediated immunity (GO:0002707)3.27810406
103positive regulation of T cell activation (GO:0050870)3.22623903
104T cell homeostasis (GO:0043029)3.21902203
105T-helper cell differentiation (GO:0042093)3.21882983
106CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21882983
107regulation of response to interferon-gamma (GO:0060330)3.21880606
108antigen processing and presentation via MHC class Ib (GO:0002475)3.20294461
109negative regulation of alpha-beta T cell differentiation (GO:0046639)3.19762090
110hepatocyte apoptotic process (GO:0097284)3.19368164
111regulation of cell killing (GO:0031341)3.19024429
112regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.16356292
113translational termination (GO:0006415)3.15038469
114Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14347058
115regulation of immunoglobulin production (GO:0002637)3.13164749
116regulation of T cell mediated cytotoxicity (GO:0001914)3.13097204
117tolerance induction (GO:0002507)3.12063616
118regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.11401634
119positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09030703
120positive regulation of granulocyte differentiation (GO:0030854)3.08961136
121positive regulation by organism of defense response of other organism involved in symbiotic interact3.08373032
122modulation by symbiont of host immune response (GO:0052553)3.08373032
123positive regulation by symbiont of host defense response (GO:0052509)3.08373032
124modulation by symbiont of host defense response (GO:0052031)3.08373032
125modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08373032
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08373032
127alpha-beta T cell differentiation involved in immune response (GO:0002293)3.08319034
128alpha-beta T cell activation involved in immune response (GO:0002287)3.08319034
129T cell differentiation involved in immune response (GO:0002292)3.08319034
130negative regulation of interleukin-12 production (GO:0032695)3.07985130
131regulation of granulocyte differentiation (GO:0030852)3.07256991
132positive regulation of lymphocyte mediated immunity (GO:0002708)3.06462609
133natural killer cell differentiation (GO:0001779)3.05923500
134regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.05724283
135positive regulation of immunoglobulin production (GO:0002639)3.05011754
136natural killer cell activation (GO:0030101)3.04695475
137cellular extravasation (GO:0045123)3.03878333
138positive regulation of alpha-beta T cell activation (GO:0046635)3.03875433
139type I interferon signaling pathway (GO:0060337)2.98851655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.03570332
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.61883425
3E2F7_22180533_ChIP-Seq_HELA_Human4.05332957
4RUNX_20019798_ChIP-Seq_JUKART_Human3.88983590
5MYC_22102868_ChIP-Seq_BL_Human3.87571080
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.84295877
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.82084674
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.54436669
9MYB_26560356_Chip-Seq_TH2_Human3.52486657
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.40619371
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29020074
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.11457884
13MAF_26560356_Chip-Seq_TH1_Human3.04498992
14UTX_26944678_Chip-Seq_JUKART_Human2.99656737
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96055747
16MYB_26560356_Chip-Seq_TH1_Human2.74482325
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54177042
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.46890930
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44457517
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42941532
21GATA3_27048872_Chip-Seq_THYMUS_Human2.30612067
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.29173533
23MAF_26560356_Chip-Seq_TH2_Human2.27180716
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19172533
25VDR_21846776_ChIP-Seq_THP-1_Human2.18409312
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.14370467
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11315743
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.93430500
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.90578949
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86516611
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82691936
32SPI1_23547873_ChIP-Seq_NB4_Human1.82356630
33TCF7_22412390_ChIP-Seq_EML_Mouse1.81813731
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74804123
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73236963
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71779653
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.71360714
38KDM2B_26808549_Chip-Seq_DND41_Human1.70737087
39RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.62807513
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60186215
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59403654
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57267902
43VDR_24763502_ChIP-Seq_THP-1_Human1.56474897
44SCL_19346495_ChIP-Seq_HPC-7_Human1.55610722
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53418174
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51429799
47CIITA_25753668_ChIP-Seq_RAJI_Human1.49163107
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.48236036
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45356507
50VDR_23849224_ChIP-Seq_CD4+_Human1.41873217
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40055656
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.39676066
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.36966154
54SPI1_23127762_ChIP-Seq_K562_Human1.36422170
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35102079
56FOXP3_21729870_ChIP-Seq_TREG_Human1.31268619
57GATA1_22025678_ChIP-Seq_K562_Human1.30093797
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30092793
59GATA3_26560356_Chip-Seq_TH2_Human1.28937998
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26878468
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21552083
62VDR_24787735_ChIP-Seq_THP-1_Human1.17454201
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17340986
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.13583307
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12706554
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10934347
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09951890
68ELK1_19687146_ChIP-ChIP_HELA_Human1.08155087
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06971116
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.04641163
71PU_27001747_Chip-Seq_BMDM_Mouse1.02203242
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99939045
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99362181
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98630381
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.98008288
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97576089
77EST1_17652178_ChIP-ChIP_JURKAT_Human0.97475828
78GATA3_26560356_Chip-Seq_TH1_Human0.97203504
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96798351
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95773676
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95421256
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94873462
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94605205
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94545648
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94025310
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92647622
87XRN2_22483619_ChIP-Seq_HELA_Human0.92646850
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92045877
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91505428
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91494286
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91479284
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90300754
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89243600
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86380586
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84952575
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83096890
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83072084
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82517821
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81326229
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.77349205
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77158525
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76727157
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75728998
104NCOR1_26117541_ChIP-Seq_K562_Human0.72954541
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72667245
106SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72560969
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70887323
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.70754543
109ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68667678
110GATA1_19941826_ChIP-Seq_K562_Human0.68614762
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.68231787
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67305379
113EGR1_19032775_ChIP-ChIP_M12_Human0.66884597
114TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65701684
115FLI1_21867929_ChIP-Seq_CD8_Mouse0.64146892
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62568689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.77807407
2MP0005671_abnormal_response_to4.96129472
3MP0000685_abnormal_immune_system3.59556623
4MP0000703_abnormal_thymus_morphology3.36795894
5MP0009333_abnormal_splenocyte_physiolog3.34443637
6MP0002398_abnormal_bone_marrow3.16604701
7MP0001800_abnormal_humoral_immune3.11856756
8MP0002420_abnormal_adaptive_immunity3.04405344
9MP0002166_altered_tumor_susceptibility2.99642216
10MP0001819_abnormal_immune_cell2.98438076
11MP0005000_abnormal_immune_tolerance2.94519834
12MP0001835_abnormal_antigen_presentation2.90499665
13MP0002723_abnormal_immune_serum2.81373399
14MP0001790_abnormal_immune_system2.77456462
15MP0005387_immune_system_phenotype2.77456462
16MP0000716_abnormal_immune_system2.70673458
17MP0002405_respiratory_system_inflammati2.69707742
18MP0002722_abnormal_immune_system2.65096282
19MP0006082_CNS_inflammation2.53776165
20MP0002452_abnormal_antigen_presenting2.50050680
21MP0002006_tumorigenesis2.46089263
22MP0000689_abnormal_spleen_morphology2.39558216
23MP0005025_abnormal_response_to2.38549195
24MP0003724_increased_susceptibility_to2.34578734
25MP0009785_altered_susceptibility_to2.31966690
26MP0003866_abnormal_defecation2.23669502
27MP0003300_gastrointestinal_ulcer2.21645753
28MP0002429_abnormal_blood_cell2.17862630
29MP0004947_skin_inflammation2.14804916
30MP0003436_decreased_susceptibility_to2.13255410
31MP0002396_abnormal_hematopoietic_system2.12537328
32MP0002933_joint_inflammation2.07709634
33MP0010155_abnormal_intestine_physiology2.05146633
34MP0001873_stomach_inflammation2.01929167
35MP0002148_abnormal_hypersensitivity_rea1.83712005
36MP0000858_altered_metastatic_potential1.83532454
37MP0004381_abnormal_hair_follicle1.76027369
38MP0005464_abnormal_platelet_physiology1.72149646
39MP0003303_peritoneal_inflammation1.68943091
40MP0001845_abnormal_inflammatory_respons1.67584418
41MP0002419_abnormal_innate_immunity1.66855955
42MP0003448_altered_tumor_morphology1.48640733
43MP0005451_abnormal_body_composition1.47223319
44MP0004808_abnormal_hematopoietic_stem1.46800376
45MP0003183_abnormal_peptide_metabolism1.39432016
46MP0002132_abnormal_respiratory_system1.27768602
47MP0002138_abnormal_hepatobiliary_system1.19766757
48MP0005075_abnormal_melanosome_morpholog1.17205044
49MP0001853_heart_inflammation1.15946555
50MP0002019_abnormal_tumor_incidence1.14175339
51MP0000465_gastrointestinal_hemorrhage1.13578800
52MP0004510_myositis1.10424576
53MP0008961_abnormal_basal_metabolism1.04099891
54MP0000490_abnormal_crypts_of1.03756020
55MP0004957_abnormal_blastocyst_morpholog1.01623483
56MP0008469_abnormal_protein_level0.99132107
57MP0003045_fibrosis0.97272946
58MP0001533_abnormal_skeleton_physiology0.96568469
59MP0005310_abnormal_salivary_gland0.92402839
60MP0003828_pulmonary_edema0.90076711
61MP0002998_abnormal_bone_remodeling0.88796283
62MP0010352_gastrointestinal_tract_polyps0.88214579
63MP0008057_abnormal_DNA_replication0.88049826
64MP0005397_hematopoietic_system_phenotyp0.87853839
65MP0001545_abnormal_hematopoietic_system0.87853839
66MP0002009_preneoplasia0.85462296
67MP0008260_abnormal_autophagy0.84514173
68MP0008877_abnormal_DNA_methylation0.84484234
69MP0002277_abnormal_respiratory_mucosa0.84101223
70MP0005023_abnormal_wound_healing0.82552746
71MP0003787_abnormal_imprinting0.79167830
72MP0003077_abnormal_cell_cycle0.77536574
73MP0001243_abnormal_dermal_layer0.76356193
74MP0001851_eye_inflammation0.76044760
75MP0004185_abnormal_adipocyte_glucose0.76008810
76MP0008995_early_reproductive_senescence0.75294391
77MP0003172_abnormal_lysosome_physiology0.74904105
78MP0003195_calcinosis0.73951149
79MP0008007_abnormal_cellular_replicative0.71866842
80MP0009764_decreased_sensitivity_to0.70418805
81MP0002163_abnormal_gland_morphology0.66311776
82MP0009763_increased_sensitivity_to0.65405540
83MP0010094_abnormal_chromosome_stability0.65130036
84MP0003786_premature_aging0.63757580
85MP0009765_abnormal_xenobiotic_induced0.61148506
86MP0001986_abnormal_taste_sensitivity0.59377851
87MP0005174_abnormal_tail_pigmentation0.58240746
88MP0000477_abnormal_intestine_morphology0.57508458
89MP0003795_abnormal_bone_structure0.57208616
90MP0004883_abnormal_blood_vessel0.54549107
91MP0002136_abnormal_kidney_physiology0.54421090
92MP0000609_abnormal_liver_physiology0.54135350
93MP0004264_abnormal_extraembryonic_tissu0.53911220
94MP0002877_abnormal_melanocyte_morpholog0.53759172
95MP0003693_abnormal_embryo_hatching0.52968196
96MP0005076_abnormal_cell_differentiation0.49616651
97MP0008770_decreased_survivor_rate0.48802178
98MP0009278_abnormal_bone_marrow0.48190558
99MP0005379_endocrine/exocrine_gland_phen0.48057109
100MP0001216_abnormal_epidermal_layer0.47166066
101MP0008873_increased_physiological_sensi0.46569811
102MP0008569_lethality_at_weaning0.46028948
103MP0000350_abnormal_cell_proliferation0.43874734
104MP0002083_premature_death0.43867591
105MP0000920_abnormal_myelination0.43065512
106MP0001663_abnormal_digestive_system0.42654192
107MP0002095_abnormal_skin_pigmentation0.41894367
108MP0001730_embryonic_growth_arrest0.41507702
109MP0004130_abnormal_muscle_cell0.41428027
110MP0001191_abnormal_skin_condition0.41042019
111MP0005666_abnormal_adipose_tissue0.40912374
112MP0003191_abnormal_cellular_cholesterol0.40301778
113MP0009115_abnormal_fat_cell0.40117871
114MP0005381_digestive/alimentary_phenotyp0.39893486
115MP0003252_abnormal_bile_duct0.39857523
116MP0000313_abnormal_cell_death0.39459556
117MP0000249_abnormal_blood_vessel0.39071193
118MP0003943_abnormal_hepatobiliary_system0.37322850
119MP0000367_abnormal_coat/_hair0.37287722
120MP0006054_spinal_hemorrhage0.37219006
121MP0001765_abnormal_ion_homeostasis0.36544560
122MP0002693_abnormal_pancreas_physiology0.36322108
123MP0002822_catalepsy0.35320109
124MP0005166_decreased_susceptibility_to0.35212901
125MP0002970_abnormal_white_adipose0.33868318
126MP0000604_amyloidosis0.33578098
127MP0003453_abnormal_keratinocyte_physiol0.31131735
128MP0003111_abnormal_nucleus_morphology0.31082759

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.64972595
2Abnormality of T cell number (HP:0011839)9.19584101
3Combined immunodeficiency (HP:0005387)6.34418249
4Severe combined immunodeficiency (HP:0004430)6.24677487
5Abnormality of T cells (HP:0002843)5.93686901
6Elevated erythrocyte sedimentation rate (HP:0003565)5.82667057
7Nasal polyposis (HP:0100582)5.18509583
8Recurrent viral infections (HP:0004429)4.97912331
9Panhypogammaglobulinemia (HP:0003139)4.93706075
10Chronic otitis media (HP:0000389)4.92224459
11Eosinophilia (HP:0001880)4.68435474
12Stomatitis (HP:0010280)4.68308649
13Recurrent bronchitis (HP:0002837)4.65884720
14IgG deficiency (HP:0004315)4.59730139
15Recurrent fungal infections (HP:0002841)4.43197935
16Abnormality of eosinophils (HP:0001879)4.42890110
17Abnormality of the nasal mucosa (HP:0000433)4.24855721
18Granulocytopenia (HP:0001913)3.95925884
19Abnormality of B cell number (HP:0010975)3.91389883
20B lymphocytopenia (HP:0010976)3.91389883
21Autoimmune hemolytic anemia (HP:0001890)3.83721946
22Leukocytosis (HP:0001974)3.80788298
23IgM deficiency (HP:0002850)3.79950940
24Joint swelling (HP:0001386)3.77156660
25Recurrent bacterial skin infections (HP:0005406)3.70132573
26Thyroiditis (HP:0100646)3.68630766
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.68117929
28Increased IgM level (HP:0003496)3.62565675
29Lymphopenia (HP:0001888)3.60488886
30Myositis (HP:0100614)3.58754391
31Pustule (HP:0200039)3.53963458
32Autoimmune thrombocytopenia (HP:0001973)3.51509063
33Eczematoid dermatitis (HP:0000976)3.49389967
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.47104317
35Abnormality of the fingertips (HP:0001211)3.36308785
36Recurrent cutaneous fungal infections (HP:0011370)3.32439002
37Chronic mucocutaneous candidiasis (HP:0002728)3.32439002
38Abnormality of macrophages (HP:0004311)3.21304857
39Hypoplasia of the thymus (HP:0000778)3.20821376
40Fatigue (HP:0012378)3.16644035
41Acute hepatic failure (HP:0006554)3.05542920
42Encephalitis (HP:0002383)3.04303003
43Chronic diarrhea (HP:0002028)2.92991107
44Abnormality of T cell physiology (HP:0011840)2.87564097
45Meningitis (HP:0001287)2.86562878
46Gastrointestinal infarctions (HP:0005244)2.82474182
47Hypochromic anemia (HP:0001931)2.81156796
48Basal cell carcinoma (HP:0002671)2.80498385
49Spontaneous hematomas (HP:0007420)2.78485997
50Bronchitis (HP:0012387)2.66922789
51Hypergammaglobulinemia (HP:0010702)2.64815331
52Recurrent gram-negative bacterial infections (HP:0005420)2.63497668
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.62318587
54Recurrent otitis media (HP:0000403)2.61427540
55Lymphoma (HP:0002665)2.60264234
56Chronic sinusitis (HP:0011109)2.58778163
57Abnormality of oral frenula (HP:0000190)2.56332092
58Hypochromic microcytic anemia (HP:0004840)2.54431339
59Papilloma (HP:0012740)2.52845445
60Verrucae (HP:0200043)2.52845445
61Anorexia (HP:0002039)2.49739258
62Papilledema (HP:0001085)2.49447312
63Hemoptysis (HP:0002105)2.49401306
64Increased IgE level (HP:0003212)2.47734991
65Thrombocytosis (HP:0001894)2.43656361
66Urticaria (HP:0001025)2.43400124
67Retrobulbar optic neuritis (HP:0100654)2.42980404
68Optic neuritis (HP:0100653)2.42980404
69Gangrene (HP:0100758)2.40018196
70Recurrent sinusitis (HP:0011108)2.36974939
71Abnormal platelet volume (HP:0011876)2.34839058
72Obstructive lung disease (HP:0006536)2.34131964
73Chronic obstructive pulmonary disease (HP:0006510)2.34131964
74Gastrointestinal stroma tumor (HP:0100723)2.32316514
75Microcytic anemia (HP:0001935)2.30836467
76Vasculitis (HP:0002633)2.28987990
77Keratoconjunctivitis sicca (HP:0001097)2.24900552
78Recurrent abscess formation (HP:0002722)2.23179900
79Abnormality of cells of the erythroid lineage (HP:0012130)2.22576536
80Pulmonary infiltrates (HP:0002113)2.19446855
81Inflammation of the large intestine (HP:0002037)2.18401539
82Abnormality of the prostate (HP:0008775)2.15924357
83Gingivitis (HP:0000230)2.15866789
84Gastrointestinal inflammation (HP:0004386)2.15405081
85Orchitis (HP:0100796)2.12406326
86Aplasia/Hypoplasia of the thymus (HP:0010515)2.11852369
87Pulmonary embolism (HP:0002204)2.09889064
88Epistaxis (HP:0000421)2.09710937
89Mediastinal lymphadenopathy (HP:0100721)2.09213091
90Aplastic anemia (HP:0001915)2.08923954
91Recurrent skin infections (HP:0001581)2.05800333
92Slow saccadic eye movements (HP:0000514)2.03619016
93Chest pain (HP:0100749)2.03576078
94Abnormal number of erythroid precursors (HP:0012131)2.03352674
95Bicuspid aortic valve (HP:0001647)2.02198274
96Ureteral stenosis (HP:0000071)2.01592667
97Bronchiectasis (HP:0002110)2.00417717
98Keratoconjunctivitis (HP:0001096)2.00352615
99Periodontitis (HP:0000704)2.00139747
100Cellular immunodeficiency (HP:0005374)1.97670836
101Arterial thrombosis (HP:0004420)1.97368588
102Amaurosis fugax (HP:0100576)1.97186147
103Hypoproteinemia (HP:0003075)1.95540048
104Cellulitis (HP:0100658)1.93748583
105Glomerulopathy (HP:0100820)1.92800535
106Trigonocephaly (HP:0000243)1.91869530
107Abnormality of the pleura (HP:0002103)1.90048302
108Prolonged bleeding time (HP:0003010)1.90038280
109Sepsis (HP:0100806)1.89065971
110IgA deficiency (HP:0002720)1.89050202
111Increased mean platelet volume (HP:0011877)1.88246209
112Prominent nose (HP:0000448)1.85720064
113Multiple enchondromatosis (HP:0005701)1.84709650
114Agammaglobulinemia (HP:0004432)1.84391278
115Dislocated radial head (HP:0003083)1.82632558
116Polyneuropathy (HP:0001271)1.80202554
117Ureteral obstruction (HP:0006000)1.79655456
118Pancytopenia (HP:0001876)1.78264637
119Purpura (HP:0000979)1.74284624
120Hepatitis (HP:0012115)1.74012689
121Abnormality of the thymus (HP:0000777)1.73110360
122Colitis (HP:0002583)1.72533096
123Seborrheic dermatitis (HP:0001051)1.70849564
124Abnormality of the radial head (HP:0003995)1.69350265
125Gingival bleeding (HP:0000225)1.69283100
126Petechiae (HP:0000967)1.66819397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.75050619
2MAP4K15.88954554
3ITK3.73307975
4ZAP703.48562055
5STK103.18236216
6RIPK42.91179218
7GRK62.74737347
8JAK32.73909310
9MST42.48857438
10FGFR42.36130222
11NLK2.30827825
12TYK22.13478341
13LCK2.04197665
14IKBKE1.92669476
15CSK1.90483657
16LRRK21.75400052
17EEF2K1.73598361
18TEC1.71023375
19NME21.59519003
20MAP3K101.59136721
21TAOK31.58645801
22PRKCH1.57938311
23SYK1.57173072
24FGFR31.55404936
25JAK11.52867181
26PKN21.49736016
27TESK21.45892022
28FGR1.40178874
29FES1.33123141
30PRKCQ1.32720848
31CAMKK21.31544848
32HCK1.31530918
33IRAK11.24679376
34CLK11.24103889
35TRIB31.23661272
36MAP3K141.22744886
37BTK1.21553797
38MARK31.21540277
39PIK3CG1.11141181
40TBK11.05923655
41MAP2K31.04789208
42CAMKK11.03026399
43SIK21.01766556
44TNK21.00744489
45TYRO30.98194870
46MAP3K10.95560402
47MAP3K110.92793586
48RPS6KA40.92260331
49SMG10.91800717
50MAP3K130.90733761
51PDGFRB0.89621612
52BLK0.87862180
53KDR0.86612311
54KSR20.86511662
55MAP3K70.84252417
56CCNB10.76717510
57PIM10.76099542
58JAK20.74117904
59SIK30.71896010
60ALK0.69038562
61MAP3K120.68364614
62PASK0.67725118
63IKBKB0.66915070
64LYN0.65368537
65MELK0.64807640
66MAP2K60.62714027
67RAF10.62488156
68EPHB10.62393372
69CDK120.61671968
70INSR0.61266835
71MAP3K30.61240677
72NUAK10.60621123
73CDK40.58674695
74EIF2AK30.58573796
75FYN0.57711706
76TAOK10.57312182
77MARK20.55080865
78ILK0.52306719
79IRAK40.52075764
80PDK10.50589398
81PRPF4B0.50042874
82HIPK20.49786966
83CDC70.49779061
84FGFR10.48526733
85CSF1R0.48089154
86STK40.47611041
87TTN0.46287351
88MAPK70.44692019
89KIT0.43938097
90STK160.43252193
91TRPM70.43147676
92RPS6KB20.42575917
93TGFBR10.42532639
94STK110.41789731
95IRAK20.39484105
96CHUK0.38555128
97TGFBR20.37115958
98MAP3K20.36982294
99RPS6KA60.36634075
100MAP3K80.35250519
101ROCK20.35032256
102MAP3K50.34857361
103SRPK10.34769829
104EPHA30.32910076
105ERN10.32882490
106NEK20.31884608
107DMPK0.31006733
108IGF1R0.30863871
109GRK70.29929968
110TRIM280.29927476
111MAPK40.29424858
112CDK90.29394021
113MAPK110.28603398
114FGFR20.28018113
115SCYL20.28010912
116RPS6KL10.27244324
117RPS6KC10.27244324
118MAPK120.26943308
119MAPKAPK20.25974117
120STK240.25953678
121PTK60.23877559
122PRKD20.22797395
123NTRK20.20576679
124MAPK30.20401637
125SIK10.19474003
126CAMK40.18835837
127TSSK60.18768193
128SGK30.18286985
129MAPK90.15214895
130CDK60.14795147

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.45614216
2T cell receptor signaling pathway_Homo sapiens_hsa046604.70093779
3Graft-versus-host disease_Homo sapiens_hsa053323.71535825
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.66153777
5Measles_Homo sapiens_hsa051622.83487040
6Antigen processing and presentation_Homo sapiens_hsa046122.82498929
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58674044
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.56390215
9Allograft rejection_Homo sapiens_hsa053302.27322740
10Hematopoietic cell lineage_Homo sapiens_hsa046402.25314411
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.15883629
12Ribosome_Homo sapiens_hsa030102.07679940
13Viral myocarditis_Homo sapiens_hsa054161.90300720
14Autoimmune thyroid disease_Homo sapiens_hsa053201.77063635
15Non-homologous end-joining_Homo sapiens_hsa034501.72930082
16Osteoclast differentiation_Homo sapiens_hsa043801.64387137
17Leishmaniasis_Homo sapiens_hsa051401.61121136
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.51607924
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50019051
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49040284
21B cell receptor signaling pathway_Homo sapiens_hsa046621.39497035
22Chemokine signaling pathway_Homo sapiens_hsa040621.37701185
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.36952855
24Herpes simplex infection_Homo sapiens_hsa051681.33796005
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27592676
26Type I diabetes mellitus_Homo sapiens_hsa049401.21350560
27HTLV-I infection_Homo sapiens_hsa051661.20811718
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20378473
29Shigellosis_Homo sapiens_hsa051311.20151490
30Acute myeloid leukemia_Homo sapiens_hsa052211.19955822
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18359463
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18048525
33Colorectal cancer_Homo sapiens_hsa052101.15288652
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15078575
35Spliceosome_Homo sapiens_hsa030401.13688521
36Hepatitis B_Homo sapiens_hsa051611.13614746
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08490788
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03766386
39Toxoplasmosis_Homo sapiens_hsa051451.02603221
40Pancreatic cancer_Homo sapiens_hsa052121.01272255
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91975889
42Chronic myeloid leukemia_Homo sapiens_hsa052200.88306192
43Influenza A_Homo sapiens_hsa051640.87357633
44Platelet activation_Homo sapiens_hsa046110.84654127
45Apoptosis_Homo sapiens_hsa042100.78897515
46Epstein-Barr virus infection_Homo sapiens_hsa051690.78409542
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77759349
48Notch signaling pathway_Homo sapiens_hsa043300.73970531
49African trypanosomiasis_Homo sapiens_hsa051430.73916910
50Inositol phosphate metabolism_Homo sapiens_hsa005620.72424761
51Viral carcinogenesis_Homo sapiens_hsa052030.70984832
52Staphylococcus aureus infection_Homo sapiens_hsa051500.70791492
53TNF signaling pathway_Homo sapiens_hsa046680.70345210
54Non-small cell lung cancer_Homo sapiens_hsa052230.68457519
55VEGF signaling pathway_Homo sapiens_hsa043700.68398319
56Hepatitis C_Homo sapiens_hsa051600.64773461
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61763733
58DNA replication_Homo sapiens_hsa030300.61634676
59Legionellosis_Homo sapiens_hsa051340.59940128
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59664640
61Choline metabolism in cancer_Homo sapiens_hsa052310.56761847
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55964628
63Glioma_Homo sapiens_hsa052140.55240412
64Thyroid cancer_Homo sapiens_hsa052160.54819941
65Proteasome_Homo sapiens_hsa030500.54521848
66Salmonella infection_Homo sapiens_hsa051320.54350658
67Tuberculosis_Homo sapiens_hsa051520.53961146
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53556982
69mRNA surveillance pathway_Homo sapiens_hsa030150.52463380
70Malaria_Homo sapiens_hsa051440.52456646
71Endometrial cancer_Homo sapiens_hsa052130.51057261
72Endocytosis_Homo sapiens_hsa041440.50957208
73Prolactin signaling pathway_Homo sapiens_hsa049170.50190571
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49789637
75Rheumatoid arthritis_Homo sapiens_hsa053230.49062255
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.48889764
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.48175874
78Pertussis_Homo sapiens_hsa051330.47882099
79Renal cell carcinoma_Homo sapiens_hsa052110.46455625
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45858019
81Mismatch repair_Homo sapiens_hsa034300.45600929
82RNA degradation_Homo sapiens_hsa030180.44624435
83HIF-1 signaling pathway_Homo sapiens_hsa040660.43715281
84FoxO signaling pathway_Homo sapiens_hsa040680.41625394
85Estrogen signaling pathway_Homo sapiens_hsa049150.41619414
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41363963
87Phagosome_Homo sapiens_hsa041450.40903505
88p53 signaling pathway_Homo sapiens_hsa041150.40335934
89Asthma_Homo sapiens_hsa053100.39375411
90Rap1 signaling pathway_Homo sapiens_hsa040150.39019460
91GnRH signaling pathway_Homo sapiens_hsa049120.38784435
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38680871
93ErbB signaling pathway_Homo sapiens_hsa040120.37484133
94Prostate cancer_Homo sapiens_hsa052150.36985962
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.36672631
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35123204
97Ras signaling pathway_Homo sapiens_hsa040140.34518962
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34294903
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33190053
100Adherens junction_Homo sapiens_hsa045200.32217218
101RNA transport_Homo sapiens_hsa030130.31821496
102MAPK signaling pathway_Homo sapiens_hsa040100.31793313
103Small cell lung cancer_Homo sapiens_hsa052220.30485102
104mTOR signaling pathway_Homo sapiens_hsa041500.28426796
105Base excision repair_Homo sapiens_hsa034100.28156748
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28107278
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.27095526
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26194737
109Long-term potentiation_Homo sapiens_hsa047200.25774683
110Dorso-ventral axis formation_Homo sapiens_hsa043200.24167202
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21435655
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20720075
113Insulin resistance_Homo sapiens_hsa049310.18993285
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18880622
115Pentose phosphate pathway_Homo sapiens_hsa000300.18677952
116Pathways in cancer_Homo sapiens_hsa052000.16737162
117Cell cycle_Homo sapiens_hsa041100.16718032
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14186830
119MicroRNAs in cancer_Homo sapiens_hsa052060.14072401

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »