TRBV6-6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)9.45056379
2negative T cell selection (GO:0043383)9.43499552
3V(D)J recombination (GO:0033151)9.20877395
4negative thymic T cell selection (GO:0045060)8.26828466
5negative regulation of thymocyte apoptotic process (GO:0070244)7.54475104
6positive T cell selection (GO:0043368)6.85985613
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.64838694
8negative regulation of myotube differentiation (GO:0010832)6.23860738
9mucosal-associated lymphoid tissue development (GO:0048537)6.22814209
10Peyers patch development (GO:0048541)6.22814209
11T cell selection (GO:0045058)5.71473424
12regulation of granulocyte differentiation (GO:0030852)5.69852577
13thymic T cell selection (GO:0045061)5.67271975
14negative regulation of T cell apoptotic process (GO:0070233)5.63101710
15T cell migration (GO:0072678)5.59237312
16radial glial cell differentiation (GO:0060019)5.32609097
17positive thymic T cell selection (GO:0045059)5.25473988
18tongue development (GO:0043586)5.12721713
19generation of neurons (GO:0048699)5.10589230
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.06897667
21positive regulation by host of viral transcription (GO:0043923)5.04718360
22positive regulation of alpha-beta T cell proliferation (GO:0046641)5.00102044
23regulation of gamma-delta T cell differentiation (GO:0045586)4.90767708
24positive regulation of gamma-delta T cell activation (GO:0046645)4.81571178
25regulation of interleukin-4 production (GO:0032673)4.80465456
26regulation of thymocyte apoptotic process (GO:0070243)4.77057897
27regulation of receptor binding (GO:1900120)4.56157170
28regulation of interleukin-13 production (GO:0032656)4.52794141
29somatic stem cell division (GO:0048103)4.47973443
30dentate gyrus development (GO:0021542)4.41004436
31apoptotic process involved in morphogenesis (GO:0060561)4.34356095
32leukocyte aggregation (GO:0070486)4.24730048
33T cell receptor signaling pathway (GO:0050852)4.18058031
34somatic diversification of immune receptors via germline recombination within a single locus (GO:0004.16511272
35somatic cell DNA recombination (GO:0016444)4.16511272
36developmental pigmentation (GO:0048066)4.11083837
37alpha-beta T cell differentiation (GO:0046632)4.08990012
38regulation of alpha-beta T cell proliferation (GO:0046640)4.08872391
39negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.06724727
40T cell differentiation (GO:0030217)4.04504248
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.04413549
42T-helper cell differentiation (GO:0042093)4.04413549
43regulation of gamma-delta T cell activation (GO:0046643)4.02838283
44purine deoxyribonucleotide catabolic process (GO:0009155)3.94591480
45positive regulation of T cell differentiation in thymus (GO:0033089)3.93746484
46negative regulation of lymphocyte apoptotic process (GO:0070229)3.90890634
47regulation of interleukin-5 production (GO:0032674)3.89032954
48hypothalamus development (GO:0021854)3.87898190
49mast cell activation (GO:0045576)3.80771780
50regulation of somitogenesis (GO:0014807)3.71955962
51positive regulation of calcium-mediated signaling (GO:0050850)3.70591560
52granulocyte differentiation (GO:0030851)3.70153668
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.69940805
54cellular response to interleukin-4 (GO:0071353)3.69196411
55mast cell activation involved in immune response (GO:0002279)3.68956228
56mast cell degranulation (GO:0043303)3.68956228
57somatic diversification of immune receptors (GO:0002200)3.66657075
58regulation of T cell apoptotic process (GO:0070232)3.64543343
59regulation of defense response to virus by virus (GO:0050690)3.62039865
60modulation by host of viral transcription (GO:0043921)3.61306794
61modulation by host of symbiont transcription (GO:0052472)3.61306794
62forebrain neuron differentiation (GO:0021879)3.60351961
63regulation of B cell receptor signaling pathway (GO:0050855)3.55923753
64T cell differentiation involved in immune response (GO:0002292)3.55480197
65alpha-beta T cell differentiation involved in immune response (GO:0002293)3.55480197
66alpha-beta T cell activation involved in immune response (GO:0002287)3.55480197
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54757050
68alpha-beta T cell activation (GO:0046631)3.53914362
69mature B cell differentiation involved in immune response (GO:0002313)3.51360318
70modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.48307083
71regulation of T cell receptor signaling pathway (GO:0050856)3.47757037
72heart trabecula morphogenesis (GO:0061384)3.43865703
73positive regulation of alpha-beta T cell activation (GO:0046635)3.42952868
74regulation of isotype switching to IgG isotypes (GO:0048302)3.41353569
75positive regulation of interleukin-4 production (GO:0032753)3.40721611
76positive regulation of B cell differentiation (GO:0045579)3.40454871
77epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.38885386
78regulation of histone H3-K9 methylation (GO:0051570)3.38006886
79innate immune response in mucosa (GO:0002227)3.37407027
80T cell costimulation (GO:0031295)3.35712558
81regulation of interleukin-2 biosynthetic process (GO:0045076)3.35391443
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33303864
83lymphocyte costimulation (GO:0031294)3.32816930
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.30659432
85antigen receptor-mediated signaling pathway (GO:0050851)3.24547117
86antigen processing and presentation of endogenous antigen (GO:0019883)3.17771663
87apoptotic process involved in development (GO:1902742)3.16699179
88negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.16637902
89response to interleukin-4 (GO:0070670)3.11711223
90heart valve formation (GO:0003188)3.09146728
91negative regulation of striated muscle cell differentiation (GO:0051154)3.09054111
92T cell activation (GO:0042110)3.06806434
93ventricular trabecula myocardium morphogenesis (GO:0003222)3.05960777
94B cell proliferation (GO:0042100)3.02935518
95negative regulation of cell killing (GO:0031342)3.01905638
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01905638
97developmental programmed cell death (GO:0010623)2.98175154
98regulation of alpha-beta T cell activation (GO:0046634)2.98168227
99anatomical structure regression (GO:0060033)2.97599694
100mitotic chromosome condensation (GO:0007076)2.96966364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51947479
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.37466996
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.91135553
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50091477
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.37352821
6RUNX_20019798_ChIP-Seq_JUKART_Human3.67001506
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.55821091
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.37232740
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96517528
10MYB_26560356_Chip-Seq_TH2_Human2.79026134
11UTX_26944678_Chip-Seq_JUKART_Human2.78001128
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.77294106
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66248662
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63482762
15GATA3_27048872_Chip-Seq_THYMUS_Human2.55628606
16MYC_22102868_ChIP-Seq_BL_Human2.54397694
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38138149
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38089948
19CIITA_25753668_ChIP-Seq_RAJI_Human2.31012095
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25980315
21MYB_26560356_Chip-Seq_TH1_Human2.19063862
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.13989029
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01892451
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93698138
25MAF_26560356_Chip-Seq_TH1_Human1.93538969
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91195596
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86177778
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85992256
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.85663398
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.85444661
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78929266
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77098215
33VDR_21846776_ChIP-Seq_THP-1_Human1.74921367
34MAF_26560356_Chip-Seq_TH2_Human1.72016941
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66594202
36VDR_23849224_ChIP-Seq_CD4+_Human1.57540790
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51453885
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50389862
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50228231
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49400535
41SCL_19346495_ChIP-Seq_HPC-7_Human1.47611001
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.45365125
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40389853
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39163476
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.38750692
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.34003766
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32953446
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31108770
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29477155
50FOXP3_21729870_ChIP-Seq_TREG_Human1.27858227
51GATA3_26560356_Chip-Seq_TH2_Human1.23194356
52VDR_24763502_ChIP-Seq_THP-1_Human1.22805446
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20691804
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20374047
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16244236
56SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15725283
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.13764235
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13457523
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12620198
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12606877
61SPI1_23547873_ChIP-Seq_NB4_Human1.12501184
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12051280
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.06173542
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04606760
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04494028
66TCF7_22412390_ChIP-Seq_EML_Mouse1.03430494
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01823070
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01799214
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99838360
70KDM2B_26808549_Chip-Seq_JURKAT_Human0.99533176
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98857210
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98595355
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97945501
74MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97112413
75RUNX1_22412390_ChIP-Seq_EML_Mouse0.96893223
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96293575
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.95635166
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94860888
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94479510
80ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94075582
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93041565
82ETS1_20019798_ChIP-Seq_JURKAT_Human0.92721831
83IGF1R_20145208_ChIP-Seq_DFB_Human0.91912457
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87862659
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85411042
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85005814
87MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84400169
88MYC_18940864_ChIP-ChIP_HL60_Human0.83901585
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83324476
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82935157
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81035407
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79070261
93KDM2B_26808549_Chip-Seq_DND41_Human0.78815449
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73787938
95THAP11_20581084_ChIP-Seq_MESCs_Mouse0.71701015
96KDM5A_27292631_Chip-Seq_BREAST_Human0.71528864
97SPI1_23127762_ChIP-Seq_K562_Human0.71206592
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70067730
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69606721
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69268058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle7.16891074
2MP0003763_abnormal_thymus_physiology6.72118143
3MP0005671_abnormal_response_to4.51972984
4MP0002396_abnormal_hematopoietic_system4.19905503
5MP0005075_abnormal_melanosome_morpholog4.12672672
6MP0000703_abnormal_thymus_morphology3.42068533
7MP0009697_abnormal_copulation2.59406657
8MP0000685_abnormal_immune_system2.42954357
9MP0010094_abnormal_chromosome_stability2.39445915
10MP0002405_respiratory_system_inflammati2.37407283
11MP0002398_abnormal_bone_marrow2.30488998
12MP0003693_abnormal_embryo_hatching2.26187323
13MP0003646_muscle_fatigue2.23840421
14MP0001800_abnormal_humoral_immune2.14069145
15MP0005000_abnormal_immune_tolerance2.12705557
16MP0002009_preneoplasia2.12606469
17MP0002722_abnormal_immune_system2.05810756
18MP0008877_abnormal_DNA_methylation2.00801355
19MP0002420_abnormal_adaptive_immunity1.99479277
20MP0001819_abnormal_immune_cell1.91724988
21MP0000716_abnormal_immune_system1.85962020
22MP0002166_altered_tumor_susceptibility1.84910851
23MP0009785_altered_susceptibility_to1.83164575
24MP0003724_increased_susceptibility_to1.81304159
25MP0008057_abnormal_DNA_replication1.75870371
26MP0001835_abnormal_antigen_presentation1.75429487
27MP0000689_abnormal_spleen_morphology1.73153625
28MP0005025_abnormal_response_to1.71428707
29MP0002723_abnormal_immune_serum1.67965732
30MP0009333_abnormal_splenocyte_physiolog1.65425277
31MP0001243_abnormal_dermal_layer1.64005080
32MP0002429_abnormal_blood_cell1.49508395
33MP0004947_skin_inflammation1.49387059
34MP0002452_abnormal_antigen_presenting1.48561487
35MP0003436_decreased_susceptibility_to1.46457126
36MP0003111_abnormal_nucleus_morphology1.34741872
37MP0000015_abnormal_ear_pigmentation1.32776280
38MP0002148_abnormal_hypersensitivity_rea1.32500754
39MP0003866_abnormal_defecation1.32014986
40MP0002006_tumorigenesis1.31789321
41MP0004957_abnormal_blastocyst_morpholog1.30531951
42MP0002098_abnormal_vibrissa_morphology1.30120233
43MP0010155_abnormal_intestine_physiology1.25510432
44MP0005377_hearing/vestibular/ear_phenot1.24855605
45MP0003878_abnormal_ear_physiology1.24855605
46MP0002933_joint_inflammation1.23765716
47MP0001919_abnormal_reproductive_system1.22679315
48MP0005464_abnormal_platelet_physiology1.18887558
49MP0005387_immune_system_phenotype1.15706466
50MP0001790_abnormal_immune_system1.15706466
51MP0003252_abnormal_bile_duct1.13489398
52MP0003011_delayed_dark_adaptation1.10468877
53MP0002019_abnormal_tumor_incidence1.08868136
54MP0000490_abnormal_crypts_of1.07152168
55MP0003300_gastrointestinal_ulcer1.06217381
56MP0002095_abnormal_skin_pigmentation0.99883797
57MP0005645_abnormal_hypothalamus_physiol0.97302630
58MP0003077_abnormal_cell_cycle0.97234566
59MP0009278_abnormal_bone_marrow0.94260786
60MP0002877_abnormal_melanocyte_morpholog0.93204690
61MP0004130_abnormal_muscle_cell0.92252254
62MP0001845_abnormal_inflammatory_respons0.92034478
63MP0005360_urolithiasis0.90299814
64MP0002163_abnormal_gland_morphology0.85137001
65MP0002419_abnormal_innate_immunity0.80588221
66MP0001730_embryonic_growth_arrest0.80578179
67MP0003787_abnormal_imprinting0.77151414
68MP0000465_gastrointestinal_hemorrhage0.74093628
69MP0008058_abnormal_DNA_repair0.72618146
70MP0005389_reproductive_system_phenotype0.72362144
71MP0004145_abnormal_muscle_electrophysio0.72281441
72MP0001661_extended_life_span0.72272559
73MP0001765_abnormal_ion_homeostasis0.71823402
74MP0004185_abnormal_adipocyte_glucose0.69333533
75MP0004043_abnormal_pH_regulation0.67639187
76MP0010307_abnormal_tumor_latency0.65329891
77MP0001873_stomach_inflammation0.65016959
78MP0000627_abnormal_mammary_gland0.64999021
79MP0005310_abnormal_salivary_gland0.64655458
80MP0001879_abnormal_lymphatic_vessel0.63394825
81MP0002970_abnormal_white_adipose0.62607484
82MP0005647_abnormal_sex_gland0.61122209
83MP0003045_fibrosis0.60659370
84MP0000313_abnormal_cell_death0.59127648
85MP0005365_abnormal_bile_salt0.55360997
86MP0002693_abnormal_pancreas_physiology0.54678491
87MP0000377_abnormal_hair_follicle0.54168214
88MP0002638_abnormal_pupillary_reflex0.53879107
89MP0008961_abnormal_basal_metabolism0.51701813
90MP0003448_altered_tumor_morphology0.51557176
91MP0008995_early_reproductive_senescence0.50344493
92MP0009931_abnormal_skin_appearance0.49489172
93MP0001853_heart_inflammation0.49196212
94MP0004808_abnormal_hematopoietic_stem0.48744306
95MP0002136_abnormal_kidney_physiology0.47911517
96MP0004264_abnormal_extraembryonic_tissu0.47618982
97MP0002876_abnormal_thyroid_physiology0.47084615
98MP0003191_abnormal_cellular_cholesterol0.46210074
99MP0001756_abnormal_urination0.45221379
100MP0004036_abnormal_muscle_relaxation0.44984651

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)9.68343311
2Combined immunodeficiency (HP:0005387)8.30705355
3B lymphocytopenia (HP:0010976)7.72263087
4Abnormality of B cell number (HP:0010975)7.12809236
5Thyroiditis (HP:0100646)6.96936884
6Panhypogammaglobulinemia (HP:0003139)6.39166706
7Autoimmune hemolytic anemia (HP:0001890)6.32267558
8T lymphocytopenia (HP:0005403)5.84721579
9Autoimmune thrombocytopenia (HP:0001973)5.21209534
10Abnormality of T cell number (HP:0011839)5.05025099
11Abnormality of the left ventricular outflow tract (HP:0011103)4.82883463
12Subaortic stenosis (HP:0001682)4.82883463
13Abnormality of the columella (HP:0009929)4.44803931
14Abnormality of T cells (HP:0002843)3.84415378
15Hypoplasia of the thymus (HP:0000778)3.79053642
16Broad face (HP:0000283)3.76404691
17IgG deficiency (HP:0004315)3.66051507
18Recurrent viral infections (HP:0004429)3.65685680
19Eosinophilia (HP:0001880)3.65600180
20Nephroblastoma (Wilms tumor) (HP:0002667)3.63405243
21Increased IgE level (HP:0003212)3.63034520
22Recurrent fungal infections (HP:0002841)3.56445459
23Abnormality of eosinophils (HP:0001879)3.48374133
24Eczematoid dermatitis (HP:0000976)3.41360469
25Embryonal renal neoplasm (HP:0011794)3.39058126
26Aplastic anemia (HP:0001915)3.37845193
27Lymphopenia (HP:0001888)3.15663285
28Granulocytopenia (HP:0001913)3.10974662
29Hypoproteinemia (HP:0003075)3.08620797
30Aplasia cutis congenita (HP:0001057)3.07025017
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.89706618
32Abnormality of cells of the lymphoid lineage (HP:0012140)2.81297731
33Lymphoma (HP:0002665)2.80805032
34Acute lymphatic leukemia (HP:0006721)2.80269474
35Aplasia/Hypoplasia of the thymus (HP:0010515)2.77230106
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77119955
37IgM deficiency (HP:0002850)2.74500111
38Chronic diarrhea (HP:0002028)2.69241200
39Mesangial abnormality (HP:0001966)2.49330352
40Reduced antithrombin III activity (HP:0001976)2.46443936
41Elevated erythrocyte sedimentation rate (HP:0003565)2.45995347
42Spontaneous hematomas (HP:0007420)2.44412906
43Chromsome breakage (HP:0040012)2.43393297
44Leukocytosis (HP:0001974)2.43305370
45Pigmentary retinal degeneration (HP:0001146)2.40648537
46Prostate neoplasm (HP:0100787)2.36242952
47Volvulus (HP:0002580)2.29780444
48Inflammation of the large intestine (HP:0002037)2.28456224
49Colon cancer (HP:0003003)2.28268463
50Gastrointestinal inflammation (HP:0004386)2.23037521
51Abnormality of the thymus (HP:0000777)2.18678026
52Abnormality of T cell physiology (HP:0011840)2.18247489
53Hematochezia (HP:0002573)2.13570272
54Abnormality of chromosome segregation (HP:0002916)2.12768224
55Embryonal neoplasm (HP:0002898)2.12151428
56Meningitis (HP:0001287)2.10604779
57Abnormality of homocysteine metabolism (HP:0010919)2.10523637
58Homocystinuria (HP:0002156)2.10523637
59Adactyly (HP:0009776)2.07384118
60Encephalitis (HP:0002383)2.05929330
61Skull defect (HP:0001362)1.95257235
62Increased circulating renin level (HP:0000848)1.94573641
63Cutis marmorata (HP:0000965)1.91197706
64Tetany (HP:0001281)1.90582547
65Abnormality of the prostate (HP:0008775)1.89511305
66Stomatitis (HP:0010280)1.89317907
67Prominent nose (HP:0000448)1.86687016
68Amaurosis fugax (HP:0100576)1.84867942
69Colitis (HP:0002583)1.83039445
70Abnormality of the ileum (HP:0001549)1.81271982
71Pancreatic islet-cell hyperplasia (HP:0004510)1.76873522
72Recurrent cutaneous fungal infections (HP:0011370)1.75201449
73Chronic mucocutaneous candidiasis (HP:0002728)1.75201449
74Abnormality of chromosome stability (HP:0003220)1.73952993
75Pseudobulbar signs (HP:0002200)1.72853186
76Cavernous hemangioma (HP:0001048)1.68769259
77Porencephaly (HP:0002132)1.64104407
78Dysphonia (HP:0001618)1.61895415
79Hypomagnesemia (HP:0002917)1.59151988
80Gastrointestinal infarctions (HP:0005244)1.59058539
81Absent thumb (HP:0009777)1.58227625
82Abnormality of the right ventricle (HP:0001707)1.56536003
83Increased IgM level (HP:0003496)1.54688914
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.54040130
85Abnormality of the preputium (HP:0100587)1.52181898
86Hyperlipoproteinemia (HP:0010980)1.51930029
87Trigonocephaly (HP:0000243)1.51148538
88Duodenal stenosis (HP:0100867)1.50864008
89Small intestinal stenosis (HP:0012848)1.50864008
90Myelodysplasia (HP:0002863)1.49938540
91Hypergammaglobulinemia (HP:0010702)1.47816964
92Abnormality of the parietal bone (HP:0002696)1.45538406
93Sepsis (HP:0100806)1.42284332
94Reticulocytopenia (HP:0001896)1.41606902
95Basal cell carcinoma (HP:0002671)1.41280258
96Cupped ribs (HP:0000887)1.40984542
97Vasculitis (HP:0002633)1.40482897
98Pancytopenia (HP:0001876)1.39526714
99Chronic obstructive pulmonary disease (HP:0006510)1.39245955
100Obstructive lung disease (HP:0006536)1.39245955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK5.90295453
2TESK25.74613369
3TXK4.10887742
4MAP3K103.30002554
5PASK3.10115328
6CDK123.00992065
7SCYL22.97265616
8ZAP702.53508570
9MAP4K12.21662417
10TLK12.17317008
11CAMKK12.17030429
12ZAK2.02265780
13ITK1.99072818
14VRK11.94593511
15MUSK1.90256846
16RPS6KA41.87561326
17BTK1.85859265
18MAP3K121.78228489
19TAF11.68020314
20RPS6KA51.51872694
21CAMKK21.51379400
22SMG11.47184605
23CDC71.45855468
24MAP3K71.45673533
25KDR1.39691282
26MAP3K111.37744133
27SYK1.36305015
28BRD41.30110459
29GRK61.24937922
30CLK11.24131413
31PIK3CG1.21284724
32ICK1.15716403
33CDK71.14737042
34CAMK11.13914564
35BUB11.13656181
36MAP3K31.11290115
37TESK11.06544978
38LCK0.99801262
39VRK20.99497269
40CDK60.98912987
41TNK20.96046378
42CAMK40.95280332
43CDK30.92282794
44MELK0.92190294
45CDK40.92170255
46FES0.91800986
47TEC0.89599668
48CSK0.84479057
49MAPK110.84207401
50DAPK30.82643332
51PRPF4B0.82208311
52PRKCQ0.82164792
53STK40.78532235
54CHEK20.77148266
55MARK20.72746606
56MST40.69437694
57LYN0.65860888
58PIM10.62615441
59AURKB0.62290436
60MAPK130.60481941
61TAOK20.60230487
62HCK0.59923909
63ATR0.59190500
64AURKA0.55364076
65BRSK10.52445126
66TAOK10.50002347
67NEK60.49988711
68RIPK10.49845973
69RPS6KB20.49030739
70IKBKE0.47975143
71TRIB30.43094553
72CHEK10.38043261
73FYN0.37275783
74PLK40.36856207
75NUAK10.35901941
76TTK0.35800329
77CDK90.34506644
78TYK20.34044321
79PDGFRB0.32871788
80CDK80.30928176
81TAOK30.29083452
82MAP3K20.28651469
83PIM20.27980464
84FGFR20.26925997
85SGK30.25202718
86MAP2K30.24748592
87ATM0.24302402
88HIPK20.23236983
89PRKCB0.22427144
90IRAK40.20317563
91RAF10.18905040
92MAP3K90.17971819
93CDK20.17719837
94CSF1R0.17487425
95CDK10.16136453
96RPS6KL10.16056222
97RPS6KC10.16056222
98WNK10.14801510
99SGK20.14662519
100RPS6KA60.14514335

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.70060133
2Systemic lupus erythematosus_Homo sapiens_hsa053225.37622975
3Alcoholism_Homo sapiens_hsa050343.95835272
4T cell receptor signaling pathway_Homo sapiens_hsa046603.32866494
5Thyroid cancer_Homo sapiens_hsa052163.08371612
6Hematopoietic cell lineage_Homo sapiens_hsa046402.96620778
7Viral carcinogenesis_Homo sapiens_hsa052032.63198266
8Cell cycle_Homo sapiens_hsa041102.53027996
9DNA replication_Homo sapiens_hsa030302.35154571
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27965097
11Non-small cell lung cancer_Homo sapiens_hsa052231.91064310
12Measles_Homo sapiens_hsa051621.87660635
13Acute myeloid leukemia_Homo sapiens_hsa052211.61782670
14Notch signaling pathway_Homo sapiens_hsa043301.60859206
15Colorectal cancer_Homo sapiens_hsa052101.58500960
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.58315657
17Endometrial cancer_Homo sapiens_hsa052131.54892459
18Mismatch repair_Homo sapiens_hsa034301.53400842
19Prostate cancer_Homo sapiens_hsa052151.39658123
20Homologous recombination_Homo sapiens_hsa034401.37562170
21Antigen processing and presentation_Homo sapiens_hsa046121.36005866
22Pancreatic cancer_Homo sapiens_hsa052121.34027567
23Basal cell carcinoma_Homo sapiens_hsa052171.33115278
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31492634
25Glioma_Homo sapiens_hsa052141.26799762
26Fanconi anemia pathway_Homo sapiens_hsa034601.26123587
27Autoimmune thyroid disease_Homo sapiens_hsa053201.24391050
28Base excision repair_Homo sapiens_hsa034101.22371464
29Chronic myeloid leukemia_Homo sapiens_hsa052201.21191633
30Graft-versus-host disease_Homo sapiens_hsa053321.05938892
31Allograft rejection_Homo sapiens_hsa053301.02941206
32HTLV-I infection_Homo sapiens_hsa051661.01843730
33One carbon pool by folate_Homo sapiens_hsa006701.01131465
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93740088
35Spliceosome_Homo sapiens_hsa030400.93376477
36Ribosome_Homo sapiens_hsa030100.90573552
37Proteasome_Homo sapiens_hsa030500.90572348
38Small cell lung cancer_Homo sapiens_hsa052220.88393616
39B cell receptor signaling pathway_Homo sapiens_hsa046620.88301274
40Hepatitis B_Homo sapiens_hsa051610.87245720
41Nucleotide excision repair_Homo sapiens_hsa034200.86148397
42Melanoma_Homo sapiens_hsa052180.83641179
43Epstein-Barr virus infection_Homo sapiens_hsa051690.83198853
44MicroRNAs in cancer_Homo sapiens_hsa052060.80166264
45RNA polymerase_Homo sapiens_hsa030200.80130347
46Malaria_Homo sapiens_hsa051440.79842183
47Non-homologous end-joining_Homo sapiens_hsa034500.78374382
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78024155
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.77195310
50Adherens junction_Homo sapiens_hsa045200.72282643
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72179361
52mRNA surveillance pathway_Homo sapiens_hsa030150.71112453
53Type I diabetes mellitus_Homo sapiens_hsa049400.69606360
54Wnt signaling pathway_Homo sapiens_hsa043100.69599325
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69247553
56Dorso-ventral axis formation_Homo sapiens_hsa043200.68951634
57Retinol metabolism_Homo sapiens_hsa008300.66359539
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64133662
59Herpes simplex infection_Homo sapiens_hsa051680.62486055
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61879269
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57406199
62Osteoclast differentiation_Homo sapiens_hsa043800.55824511
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52647991
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49974371
65p53 signaling pathway_Homo sapiens_hsa041150.49840997
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49433254
67Pyrimidine metabolism_Homo sapiens_hsa002400.44356552
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.41989535
69RNA transport_Homo sapiens_hsa030130.40421515
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38186165
71Viral myocarditis_Homo sapiens_hsa054160.38084940
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37584661
73Melanogenesis_Homo sapiens_hsa049160.37075890
74Inositol phosphate metabolism_Homo sapiens_hsa005620.36068709
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34777700
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33438615
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.32586814
78Basal transcription factors_Homo sapiens_hsa030220.31844198
79Purine metabolism_Homo sapiens_hsa002300.31279693
80Chemokine signaling pathway_Homo sapiens_hsa040620.30876982
81RNA degradation_Homo sapiens_hsa030180.30302101
82Vitamin B6 metabolism_Homo sapiens_hsa007500.28340973
83Prion diseases_Homo sapiens_hsa050200.28323618
84Olfactory transduction_Homo sapiens_hsa047400.27666505
85Platelet activation_Homo sapiens_hsa046110.27012244
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25082857
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24422629
88TNF signaling pathway_Homo sapiens_hsa046680.22680519
89FoxO signaling pathway_Homo sapiens_hsa040680.22234167
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.21524669
91VEGF signaling pathway_Homo sapiens_hsa043700.20610228
92Pathways in cancer_Homo sapiens_hsa052000.20396360
93Taste transduction_Homo sapiens_hsa047420.18929997
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17376574
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17342490
96Shigellosis_Homo sapiens_hsa051310.16657459
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15096646
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13379134
99Oocyte meiosis_Homo sapiens_hsa041140.13376313
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12913245

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