TRBV6-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.07397360
2negative T cell selection (GO:0043383)7.05370976
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.00557843
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.62224113
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.43803947
6negative regulation of cell killing (GO:0031342)6.43803947
7positive T cell selection (GO:0043368)6.26269588
8cellular response to interleukin-15 (GO:0071350)5.87076574
9cytidine deamination (GO:0009972)5.84943436
10cytidine metabolic process (GO:0046087)5.84943436
11cytidine catabolic process (GO:0006216)5.84943436
12negative thymic T cell selection (GO:0045060)5.73690247
13positive regulation of gamma-delta T cell activation (GO:0046645)5.62261085
14response to interleukin-15 (GO:0070672)5.58546179
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53113442
16regulation of regulatory T cell differentiation (GO:0045589)5.40264458
17tolerance induction (GO:0002507)5.36811975
18pyrimidine ribonucleoside catabolic process (GO:0046133)5.27129594
19positive regulation of T cell mediated cytotoxicity (GO:0001916)5.20507737
20DNA deamination (GO:0045006)5.17464582
21regulation of isotype switching to IgG isotypes (GO:0048302)5.11835142
22activated T cell proliferation (GO:0050798)5.05900612
23negative regulation of T cell mediated immunity (GO:0002710)5.04318268
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.01290630
25positive thymic T cell selection (GO:0045059)4.97864192
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.96874027
27T cell selection (GO:0045058)4.94542200
28antigen processing and presentation of endogenous antigen (GO:0019883)4.86421715
29regulation of T cell mediated cytotoxicity (GO:0001914)4.85299897
30T cell migration (GO:0072678)4.85242953
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.72595023
32thymic T cell selection (GO:0045061)4.69483346
33cellular response to interferon-beta (GO:0035458)4.61199182
34positive regulation of defense response to virus by host (GO:0002230)4.59971946
35negative regulation of stress fiber assembly (GO:0051497)4.57101466
36regulation of gamma-delta T cell differentiation (GO:0045586)4.50242566
37regulation of leukocyte mediated cytotoxicity (GO:0001910)4.40936818
38regulation of T cell tolerance induction (GO:0002664)4.37906729
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.35798543
40regulation of natural killer cell mediated immunity (GO:0002715)4.35798543
41positive regulation of cell killing (GO:0031343)4.26390037
42negative regulation of lymphocyte mediated immunity (GO:0002707)4.25991381
43regulation of interleukin-2 biosynthetic process (GO:0045076)4.20392670
44antigen processing and presentation via MHC class Ib (GO:0002475)4.19078496
45regulation of gamma-delta T cell activation (GO:0046643)4.18402752
46T cell receptor signaling pathway (GO:0050852)4.15042022
47positive regulation of natural killer cell mediated immunity (GO:0002717)4.13636077
48positive regulation of B cell differentiation (GO:0045579)4.12588518
49cellular defense response (GO:0006968)4.10577775
50regulation of alpha-beta T cell proliferation (GO:0046640)4.05824735
51negative regulation of interleukin-12 production (GO:0032695)4.00926046
52regulation of B cell differentiation (GO:0045577)3.98878778
53interferon-gamma production (GO:0032609)3.98491291
54regulation of cell killing (GO:0031341)3.97016548
55positive regulation of tolerance induction (GO:0002645)3.90727136
56response to interferon-beta (GO:0035456)3.89639222
57positive regulation of granulocyte differentiation (GO:0030854)3.85692063
58leukocyte aggregation (GO:0070486)3.85308236
59positive regulation of alpha-beta T cell proliferation (GO:0046641)3.83895720
60regulation of B cell receptor signaling pathway (GO:0050855)3.82369914
61positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.77995919
62negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.74808388
63regulation of defense response to virus by host (GO:0050691)3.71730346
64antigen receptor-mediated signaling pathway (GO:0050851)3.66901758
65positive regulation of T cell mediated immunity (GO:0002711)3.62410238
66regulation of tolerance induction (GO:0002643)3.62155290
67cytolysis (GO:0019835)3.51796000
68negative regulation of leukocyte mediated immunity (GO:0002704)3.49949128
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48054041
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.43903931
71negative regulation of actin filament bundle assembly (GO:0032232)3.41987350
72positive regulation of interleukin-4 production (GO:0032753)3.41424701
73positive regulation of lymphocyte mediated immunity (GO:0002708)3.39897515
74lymphocyte migration (GO:0072676)3.39228744
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.38790149
76positive regulation of isotype switching (GO:0045830)3.36950833
77negative regulation of T cell apoptotic process (GO:0070233)3.32923785
78positive regulation of humoral immune response (GO:0002922)3.31500004
79alpha-beta T cell differentiation (GO:0046632)3.30970070
80regulation of T cell mediated immunity (GO:0002709)3.26741723
81positive regulation of calcium-mediated signaling (GO:0050850)3.18177059
82lymphocyte chemotaxis (GO:0048247)3.16827562
83regulation of T cell receptor signaling pathway (GO:0050856)3.13409412
84positive regulation of immunoglobulin mediated immune response (GO:0002891)3.13091966
85positive regulation of B cell mediated immunity (GO:0002714)3.13091966
86T cell costimulation (GO:0031295)3.12089691
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.10284531
88positive regulation of DNA recombination (GO:0045911)3.10245108
89lymphocyte costimulation (GO:0031294)3.08289055
90NIK/NF-kappaB signaling (GO:0038061)3.07275464
91mast cell activation (GO:0045576)3.06956351
92CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.04947091
93pentose metabolic process (GO:0019321)3.03906165
94regulation of chronic inflammatory response (GO:0002676)3.03391824
95regulation of isotype switching (GO:0045191)3.00919406
96positive regulation of leukocyte mediated immunity (GO:0002705)2.99946858
97regulation of lymphocyte mediated immunity (GO:0002706)2.97366784
98negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96875689
99negative regulation of viral genome replication (GO:0045071)2.95843685
100T cell differentiation (GO:0030217)2.92997139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.33681153
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.77293002
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.47241126
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.46340353
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.89374101
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84780819
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.73137814
8RUNX_20019798_ChIP-Seq_JUKART_Human3.64017969
9MYB_26560356_Chip-Seq_TH2_Human3.54947309
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40678015
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15509929
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.12061440
13MAF_26560356_Chip-Seq_TH1_Human2.67690742
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.62851423
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54034467
16MYB_26560356_Chip-Seq_TH1_Human2.50069749
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46994903
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.40100844
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39845147
20UTX_26944678_Chip-Seq_JUKART_Human2.24245699
21GATA3_27048872_Chip-Seq_THYMUS_Human2.22173997
22MAF_26560356_Chip-Seq_TH2_Human2.14857837
23GATA3_26560356_Chip-Seq_TH2_Human2.11185173
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06409273
25CIITA_25753668_ChIP-Seq_RAJI_Human2.00640626
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99046386
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97119653
28SPI1_23547873_ChIP-Seq_NB4_Human1.96905068
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.87387281
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.83083269
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77041295
32RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.74476085
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58501071
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56586316
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.55655249
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55386463
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.53704168
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51037917
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41570833
40VDR_23849224_ChIP-Seq_CD4+_Human1.35867052
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34462744
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34362005
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32707872
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30482981
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24117754
46VDR_24763502_ChIP-Seq_THP-1_Human1.22866193
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19880568
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17405132
49FOXP3_21729870_ChIP-Seq_TREG_Human1.17153700
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15777044
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11986944
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09699312
53VDR_22108803_ChIP-Seq_LS180_Human1.08966685
54SPI1_23127762_ChIP-Seq_K562_Human1.07940525
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04612694
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.04567897
57RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04539310
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01872908
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98521651
60VDR_24787735_ChIP-Seq_THP-1_Human0.97977492
61HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97782172
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96884455
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95391792
64FLI1_27457419_Chip-Seq_LIVER_Mouse0.95323350
65MYC_22102868_ChIP-Seq_BL_Human0.94601328
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94289219
67EST1_17652178_ChIP-ChIP_JURKAT_Human0.93157440
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92886386
69PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92434213
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92015726
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90438328
72TCF7_22412390_ChIP-Seq_EML_Mouse0.89673084
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88837780
74PU_27001747_Chip-Seq_BMDM_Mouse0.87870342
75SMRT_27268052_Chip-Seq_Bcells_Human0.87850677
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86650169
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85277763
78SCL_19346495_ChIP-Seq_HPC-7_Human0.85009385
79BCOR_27268052_Chip-Seq_Bcells_Human0.84946358
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84944717
81BCL6_27268052_Chip-Seq_Bcells_Human0.84814109
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.84769009
83GATA3_26560356_Chip-Seq_TH1_Human0.83435002
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.81648759
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80631393
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79839281
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78658792
88P300_27268052_Chip-Seq_Bcells_Human0.78254612
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77413746
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76301256
91STAT1_20625510_ChIP-Seq_HELA_Human0.75685757
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74347745
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73962744
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73854361
95HTT_18923047_ChIP-ChIP_STHdh_Human0.71306083
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.70764436
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70508270
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69351143
99VDR_21846776_ChIP-Seq_THP-1_Human0.69074351
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68113032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.02626667
2MP0003763_abnormal_thymus_physiology4.64369173
3MP0001835_abnormal_antigen_presentation4.13167890
4MP0009333_abnormal_splenocyte_physiolog3.89293716
5MP0001800_abnormal_humoral_immune3.04314854
6MP0000685_abnormal_immune_system2.96736396
7MP0003436_decreased_susceptibility_to2.92088757
8MP0001790_abnormal_immune_system2.90370338
9MP0005387_immune_system_phenotype2.90370338
10MP0001853_heart_inflammation2.89768628
11MP0009785_altered_susceptibility_to2.77702252
12MP0005025_abnormal_response_to2.74880202
13MP0005000_abnormal_immune_tolerance2.70168976
14MP0003866_abnormal_defecation2.65598698
15MP0002420_abnormal_adaptive_immunity2.65295052
16MP0002723_abnormal_immune_serum2.61395127
17MP0001819_abnormal_immune_cell2.60096510
18MP0002166_altered_tumor_susceptibility2.38391231
19MP0002452_abnormal_antigen_presenting2.38347842
20MP0002405_respiratory_system_inflammati2.36804540
21MP0000703_abnormal_thymus_morphology2.31182446
22MP0001873_stomach_inflammation2.28508586
23MP0002148_abnormal_hypersensitivity_rea2.26472818
24MP0002419_abnormal_innate_immunity2.18957668
25MP0003300_gastrointestinal_ulcer2.17800306
26MP0006082_CNS_inflammation2.17603767
27MP0003724_increased_susceptibility_to2.12681755
28MP0010155_abnormal_intestine_physiology2.10457665
29MP0002398_abnormal_bone_marrow2.08222418
30MP0000716_abnormal_immune_system2.07058100
31MP0003045_fibrosis1.96346125
32MP0003878_abnormal_ear_physiology1.88344408
33MP0005377_hearing/vestibular/ear_phenot1.88344408
34MP0000689_abnormal_spleen_morphology1.87007507
35MP0002722_abnormal_immune_system1.73809732
36MP0002138_abnormal_hepatobiliary_system1.73108386
37MP0001845_abnormal_inflammatory_respons1.66496291
38MP0002006_tumorigenesis1.61848472
39MP0002429_abnormal_blood_cell1.58405846
40MP0002277_abnormal_respiratory_mucosa1.49120986
41MP0003448_altered_tumor_morphology1.47189267
42MP0004947_skin_inflammation1.44316175
43MP0005310_abnormal_salivary_gland1.44258082
44MP0002837_dystrophic_cardiac_calcinosis1.42312135
45MP0004381_abnormal_hair_follicle1.40118228
46MP0008469_abnormal_protein_level1.32662665
47MP0005464_abnormal_platelet_physiology1.27275697
48MP0004130_abnormal_muscle_cell1.24779001
49MP0009278_abnormal_bone_marrow1.20569611
50MP0000465_gastrointestinal_hemorrhage1.16847049
51MP0005075_abnormal_melanosome_morpholog1.14132597
52MP0001533_abnormal_skeleton_physiology1.12171934
53MP0002163_abnormal_gland_morphology1.09604680
54MP0009764_decreased_sensitivity_to1.09484486
55MP0000604_amyloidosis1.06026050
56MP0009763_increased_sensitivity_to1.02854914
57MP0003303_peritoneal_inflammation1.02034395
58MP0009840_abnormal_foam_cell1.01100131
59MP0001348_abnormal_lacrimal_gland0.99499393
60MP0005379_endocrine/exocrine_gland_phen0.95488320
61MP0000858_altered_metastatic_potential0.94755033
62MP0001501_abnormal_sleep_pattern0.90404559
63MP0001765_abnormal_ion_homeostasis0.88214474
64MP0002998_abnormal_bone_remodeling0.85768271
65MP0005167_abnormal_blood-brain_barrier0.80432930
66MP0001764_abnormal_homeostasis0.78041769
67MP0004036_abnormal_muscle_relaxation0.76007010
68MP0003191_abnormal_cellular_cholesterol0.75142258
69MP0008057_abnormal_DNA_replication0.74364656
70MP0001919_abnormal_reproductive_system0.73952532
71MP0003959_abnormal_lean_body0.72221130
72MP0002736_abnormal_nociception_after0.72068097
73MP0001986_abnormal_taste_sensitivity0.70815357
74MP0002693_abnormal_pancreas_physiology0.69422525
75MP0002933_joint_inflammation0.69378901
76MP0002168_other_aberrant_phenotype0.67735988
77MP0004142_abnormal_muscle_tone0.65727962
78MP0001663_abnormal_digestive_system0.65073991
79MP0005410_abnormal_fertilization0.63701651
80MP0001851_eye_inflammation0.61413828
81MP0001968_abnormal_touch/_nociception0.61113615
82MP0002019_abnormal_tumor_incidence0.60727049
83MP0004084_abnormal_cardiac_muscle0.59668405
84MP0005166_decreased_susceptibility_to0.59241359
85MP0008260_abnormal_autophagy0.56989412
86MP0005636_abnormal_mineral_homeostasis0.56527104
87MP0005448_abnormal_energy_balance0.56174111
88MP0002254_reproductive_system_inflammat0.55942324
89MP0008872_abnormal_physiological_respon0.55405705
90MP0003646_muscle_fatigue0.51426944
91MP0005165_increased_susceptibility_to0.50750531
92MP0006035_abnormal_mitochondrial_morpho0.49345708
93MP0000490_abnormal_crypts_of0.48184741
94MP0003075_altered_response_to0.47336163
95MP0003795_abnormal_bone_structure0.46873364
96MP0004782_abnormal_surfactant_physiolog0.45239190
97MP0005645_abnormal_hypothalamus_physiol0.45152001
98MP0005083_abnormal_biliary_tract0.44961455
99MP0005390_skeleton_phenotype0.43095846
100MP0009643_abnormal_urine_homeostasis0.42269909

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)8.35601920
2Stomatitis (HP:0010280)6.27593565
3Abnormal delayed hypersensitivity skin test (HP:0002963)5.63231063
4T lymphocytopenia (HP:0005403)5.47903021
5Chronic mucocutaneous candidiasis (HP:0002728)5.34510238
6Recurrent cutaneous fungal infections (HP:0011370)5.34510238
7Eczematoid dermatitis (HP:0000976)5.13977420
8Abnormality of T cells (HP:0002843)5.13128012
9Abnormality of T cell number (HP:0011839)5.07454404
10Panhypogammaglobulinemia (HP:0003139)5.03167184
11IgG deficiency (HP:0004315)4.82127950
12Recurrent fungal infections (HP:0002841)4.76610549
13Severe combined immunodeficiency (HP:0004430)4.71013593
14Encephalitis (HP:0002383)4.34803359
15Autoimmune hemolytic anemia (HP:0001890)4.30726133
16Agammaglobulinemia (HP:0004432)4.20178291
17Colitis (HP:0002583)3.98104605
18Myositis (HP:0100614)3.86248431
19Chronic diarrhea (HP:0002028)3.76311378
20Increased IgE level (HP:0003212)3.74517463
21Recurrent bronchitis (HP:0002837)3.73381588
22Increased IgM level (HP:0003496)3.71601067
23Abnormality of eosinophils (HP:0001879)3.66675300
24Combined immunodeficiency (HP:0005387)3.65381296
25Abnormality of T cell physiology (HP:0011840)3.58668280
26Pustule (HP:0200039)3.58187366
27Inflammation of the large intestine (HP:0002037)3.53218467
28Pigmentary retinal degeneration (HP:0001146)3.52719168
29Lymphopenia (HP:0001888)3.43222789
30Recurrent skin infections (HP:0001581)3.37333313
31Meningitis (HP:0001287)3.36668591
32Leukocytosis (HP:0001974)3.36408125
33Gastrointestinal inflammation (HP:0004386)3.29304128
34Thyroiditis (HP:0100646)3.25535100
35Villous atrophy (HP:0011473)3.19403643
36Abnormality of small intestinal villus morphology (HP:0011472)3.19403643
37Vasculitis (HP:0002633)3.17090415
38Hypoplasia of the thymus (HP:0000778)3.16720053
39Optic neuritis (HP:0100653)3.16395380
40Retrobulbar optic neuritis (HP:0100654)3.16395380
41Abnormality of cells of the lymphoid lineage (HP:0012140)3.13634154
42Eosinophilia (HP:0001880)3.03459782
43Recurrent viral infections (HP:0004429)2.98764723
44Orchitis (HP:0100796)2.98502667
45Viral hepatitis (HP:0006562)2.93291123
46Recurrent abscess formation (HP:0002722)2.91172946
47Petechiae (HP:0000967)2.80423796
48Abnormality of macrophages (HP:0004311)2.79059596
49Recurrent bacterial skin infections (HP:0005406)2.76411175
50Granulocytopenia (HP:0001913)2.74415105
51Hypergammaglobulinemia (HP:0010702)2.72894857
52Aplastic anemia (HP:0001915)2.72202671
53Keratoconjunctivitis sicca (HP:0001097)2.71620443
54Severe visual impairment (HP:0001141)2.66936488
55Pulmonary infiltrates (HP:0002113)2.65639857
56IgM deficiency (HP:0002850)2.58633373
57Lymphoma (HP:0002665)2.55431667
58Acute hepatic failure (HP:0006554)2.54721021
59Keratoconjunctivitis (HP:0001096)2.49777380
60Alveolar cell carcinoma (HP:0006519)2.48092385
61Gastrointestinal infarctions (HP:0005244)2.46841926
62Mediastinal lymphadenopathy (HP:0100721)2.46812605
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22467895
64Hepatosplenomegaly (HP:0001433)2.18717046
65Abnormality of the pleura (HP:0002103)2.17310938
66Spontaneous hematomas (HP:0007420)2.16518841
67Neoplasm of the tracheobronchial system (HP:0100552)2.15360596
68Cellular immunodeficiency (HP:0005374)2.13868769
69Neutropenia (HP:0001875)2.12677593
70Glomerulopathy (HP:0100820)2.06907025
71Hyperlipoproteinemia (HP:0010980)2.05135923
72Abnormal rod and cone electroretinograms (HP:0008323)2.04729817
73Chest pain (HP:0100749)2.04431208
74Micronodular cirrhosis (HP:0001413)2.03041247
75Skin rash (HP:0000988)2.01914139
76Autoimmune thrombocytopenia (HP:0001973)2.01456347
77Purpura (HP:0000979)2.01321622
78Pancytopenia (HP:0001876)2.00332429
79Interstitial pulmonary disease (HP:0006530)2.00191700
80Obstructive lung disease (HP:0006536)1.98621905
81Chronic obstructive pulmonary disease (HP:0006510)1.98621905
82Bronchitis (HP:0012387)1.96648994
83Thyroid-stimulating hormone excess (HP:0002925)1.96482882
84Microcytic anemia (HP:0001935)1.95579260
85Hemoptysis (HP:0002105)1.94920625
86Hepatitis (HP:0012115)1.93194827
87Hypoplasia of the pons (HP:0012110)1.87425672
88Carpal bone hypoplasia (HP:0001498)1.83712137
89Stomach cancer (HP:0012126)1.80029463
90Abnormality of the pons (HP:0007361)1.79984004
91Hypoproteinemia (HP:0003075)1.79138185
92Tetraplegia (HP:0002445)1.76871259
93Joint swelling (HP:0001386)1.76524316
94Gangrene (HP:0100758)1.76452321
95Thoracic kyphosis (HP:0002942)1.76380091
96Pulmonary embolism (HP:0002204)1.75833645
97Abnormality of B cell number (HP:0010975)1.74010960
98B lymphocytopenia (HP:0010976)1.72778953
99Slow saccadic eye movements (HP:0000514)1.72579668
100Prolonged neonatal jaundice (HP:0006579)1.70985518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.61879916
2MAP4K14.88079569
3EPHA33.83851666
4IRAK43.22987714
5EPHB13.18790312
6TESK22.99651722
7FES2.91838886
8FGFR42.61385138
9TNK22.59130519
10NLK2.45016984
11ITK2.30409063
12TAOK32.28860890
13MAP3K32.26350903
14MAP2K32.16248001
15CSK1.91086774
16ZAP701.88731500
17KDR1.85600578
18RPS6KA41.71681005
19TEC1.67077366
20TYK21.60991683
21BTK1.54937811
22ADRBK21.46204759
23IRAK11.42350171
24JAK11.37211357
25FGFR31.36585996
26IKBKE1.36429295
27LCK1.34586134
28MAP3K131.33118403
29HCK1.33078395
30SYK1.30927544
31GRK71.28795355
32RIPK41.26232435
33TBK11.18850413
34MST41.18390570
35GRK61.11106021
36IKBKB1.08169598
37MAP3K11.07791517
38CLK11.05380789
39HIPK21.01332389
40TESK11.00942026
41TAOK10.94058603
42LYN0.93771918
43JAK30.91674694
44TAOK20.91665731
45PASK0.91062974
46PRKCQ0.88780947
47MAPK120.87266838
48BLK0.76887882
49CSF1R0.76265232
50CAMKK20.75237258
51NUAK10.74701995
52MAP3K110.73330087
53SGK20.72893065
54TYRO30.68656273
55RPS6KA50.68593818
56SGK30.66488509
57RAF10.65223103
58SIK30.63889882
59PTK2B0.62108804
60FGR0.56339156
61JAK20.55750367
62SRPK10.53656930
63CAMKK10.48894335
64SGK4940.48517185
65SGK2230.48517185
66MAP3K140.47792406
67MARK30.47075734
68MAP2K60.43990480
69MAPK110.42987414
70NEK90.41294624
71MAP3K80.40788270
72NEK60.39021546
73MAP3K90.38951736
74FYN0.38751650
75BCKDK0.35395734
76CHUK0.35248595
77PRPF4B0.34040610
78MAPKAPK20.32132051
79MAP3K60.30735746
80PIM10.30649713
81STK380.28422623
82DYRK30.27799835
83STK100.27771286
84CDK40.24135390
85MAP3K120.23216142
86CAMK40.22619789
87DYRK20.22022135
88SIK20.21398660
89RET0.17596823
90PTK60.17520522
91RPS6KA60.15666993
92ALK0.15472517
93KSR20.15128860
94PDGFRB0.14573841
95INSR0.14473161
96KIT0.14394935
97TRPM70.12776871
98FER0.12431360
99PDK10.11517164
100IGF1R0.11311286

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.70510809
2Antigen processing and presentation_Homo sapiens_hsa046124.38444462
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.87875308
4Autoimmune thyroid disease_Homo sapiens_hsa053203.55040671
5Allograft rejection_Homo sapiens_hsa053303.47367029
6Graft-versus-host disease_Homo sapiens_hsa053323.47168280
7T cell receptor signaling pathway_Homo sapiens_hsa046603.30495587
8Type I diabetes mellitus_Homo sapiens_hsa049402.78409565
9Measles_Homo sapiens_hsa051622.48211710
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39727511
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08119929
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.97924108
13Proteasome_Homo sapiens_hsa030501.96390423
14Hematopoietic cell lineage_Homo sapiens_hsa046401.95939100
15Osteoclast differentiation_Homo sapiens_hsa043801.65940348
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.65762998
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.52991035
18Viral myocarditis_Homo sapiens_hsa054161.42092480
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42060058
20Chemokine signaling pathway_Homo sapiens_hsa040621.36069210
21Asthma_Homo sapiens_hsa053101.35125913
22Malaria_Homo sapiens_hsa051441.28188294
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24131965
24Leishmaniasis_Homo sapiens_hsa051401.21265008
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20001027
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18606521
27B cell receptor signaling pathway_Homo sapiens_hsa046621.15075373
28Shigellosis_Homo sapiens_hsa051311.13763781
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12292883
30Tuberculosis_Homo sapiens_hsa051521.11765665
31Acute myeloid leukemia_Homo sapiens_hsa052211.09517414
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08098560
33Toxoplasmosis_Homo sapiens_hsa051451.07763553
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06837532
35TNF signaling pathway_Homo sapiens_hsa046681.06388074
36Staphylococcus aureus infection_Homo sapiens_hsa051501.05262054
37Epstein-Barr virus infection_Homo sapiens_hsa051690.98219635
38Herpes simplex infection_Homo sapiens_hsa051680.93363518
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91917771
40Rheumatoid arthritis_Homo sapiens_hsa053230.90766458
41Apoptosis_Homo sapiens_hsa042100.85149773
42Influenza A_Homo sapiens_hsa051640.80703196
43Protein export_Homo sapiens_hsa030600.75460647
44HTLV-I infection_Homo sapiens_hsa051660.75295209
45Hepatitis B_Homo sapiens_hsa051610.73962468
46Platelet activation_Homo sapiens_hsa046110.72883628
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.72202144
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72125201
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71079721
50VEGF signaling pathway_Homo sapiens_hsa043700.66932175
51Pertussis_Homo sapiens_hsa051330.66653542
52Oxidative phosphorylation_Homo sapiens_hsa001900.64777333
53Viral carcinogenesis_Homo sapiens_hsa052030.61671600
54Regulation of autophagy_Homo sapiens_hsa041400.60595562
55Phototransduction_Homo sapiens_hsa047440.59810538
56Salmonella infection_Homo sapiens_hsa051320.59726173
57Collecting duct acid secretion_Homo sapiens_hsa049660.59572714
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58618765
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57318929
60Hepatitis C_Homo sapiens_hsa051600.54993845
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52017800
62Ribosome_Homo sapiens_hsa030100.49067386
63Parkinsons disease_Homo sapiens_hsa050120.46794245
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.44356430
65Renin secretion_Homo sapiens_hsa049240.44247590
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.43461373
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41981122
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41516001
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40380465
70Endocytosis_Homo sapiens_hsa041440.39970950
71Nitrogen metabolism_Homo sapiens_hsa009100.39793843
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39183886
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38263058
74Pancreatic cancer_Homo sapiens_hsa052120.38014400
75Basal transcription factors_Homo sapiens_hsa030220.37755441
76FoxO signaling pathway_Homo sapiens_hsa040680.37143731
77African trypanosomiasis_Homo sapiens_hsa051430.36383254
78Phagosome_Homo sapiens_hsa041450.36147230
79Sulfur metabolism_Homo sapiens_hsa009200.35930226
80Alzheimers disease_Homo sapiens_hsa050100.35703194
81Insulin resistance_Homo sapiens_hsa049310.35632619
82Spliceosome_Homo sapiens_hsa030400.33768452
83Non-small cell lung cancer_Homo sapiens_hsa052230.31554367
84HIF-1 signaling pathway_Homo sapiens_hsa040660.31163364
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30897511
86Prolactin signaling pathway_Homo sapiens_hsa049170.30605735
87Ras signaling pathway_Homo sapiens_hsa040140.29114736
88MAPK signaling pathway_Homo sapiens_hsa040100.25847605
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23684673
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.21435304
91RNA polymerase_Homo sapiens_hsa030200.21381536
92Olfactory transduction_Homo sapiens_hsa047400.20065745
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19815034
94Linoleic acid metabolism_Homo sapiens_hsa005910.19434129
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18789132
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17996656
97Legionellosis_Homo sapiens_hsa051340.16273208
98mTOR signaling pathway_Homo sapiens_hsa041500.11826128
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10950411
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10469807

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