TRBV5-6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)8.72035314
2T cell migration (GO:0072678)7.06131704
3negative T cell selection (GO:0043383)6.35774669
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.74211056
5regulation of B cell receptor signaling pathway (GO:0050855)5.71296055
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.60105670
7positive T cell selection (GO:0043368)5.48544386
8negative thymic T cell selection (GO:0045060)5.46582678
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.40536601
10negative regulation of cell killing (GO:0031342)5.36648603
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.36648603
12positive regulation of gamma-delta T cell activation (GO:0046645)5.31469565
13cytidine deamination (GO:0009972)5.22411214
14cytidine metabolic process (GO:0046087)5.22411214
15cytidine catabolic process (GO:0006216)5.22411214
16antigen processing and presentation of endogenous antigen (GO:0019883)5.11661576
17negative regulation of execution phase of apoptosis (GO:1900118)5.08642834
18cellular response to interleukin-15 (GO:0071350)5.08629743
19T cell selection (GO:0045058)5.01929123
20response to interleukin-15 (GO:0070672)4.92447792
21positive thymic T cell selection (GO:0045059)4.91074982
22regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.89264173
23regulation of natural killer cell mediated immunity (GO:0002715)4.89264173
24positive regulation of natural killer cell mediated immunity (GO:0002717)4.73455979
25pyrimidine ribonucleoside catabolic process (GO:0046133)4.70349087
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69343121
27lymphocyte chemotaxis (GO:0048247)4.67233620
28positive regulation of calcium-mediated signaling (GO:0050850)4.60869344
29thymic T cell selection (GO:0045061)4.60279925
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.57998843
31regulation of alpha-beta T cell proliferation (GO:0046640)4.35233730
32DNA deamination (GO:0045006)4.31999405
33regulation of gamma-delta T cell differentiation (GO:0045586)4.30762669
34regulation of regulatory T cell differentiation (GO:0045589)4.23052105
35tolerance induction (GO:0002507)4.22508447
36positive regulation of alpha-beta T cell proliferation (GO:0046641)4.21615178
37T cell mediated immunity (GO:0002456)4.19160389
38regulation of T cell tolerance induction (GO:0002664)4.18177958
39positive regulation of B cell differentiation (GO:0045579)4.15055384
40lymphocyte migration (GO:0072676)4.12061308
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.09508762
42leukocyte aggregation (GO:0070486)4.02358277
43regulation of defense response to virus by virus (GO:0050690)4.02215007
44positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.98435196
45positive regulation of lamellipodium assembly (GO:0010592)3.91295188
46regulation of gamma-delta T cell activation (GO:0046643)3.89904889
47cytolysis (GO:0019835)3.89899593
48T cell receptor signaling pathway (GO:0050852)3.85172011
49sequestering of actin monomers (GO:0042989)3.79159499
50chemokine-mediated signaling pathway (GO:0070098)3.78761454
51negative regulation of leukocyte mediated immunity (GO:0002704)3.77974483
52regulation of leukocyte mediated cytotoxicity (GO:0001910)3.77712734
53regulation of B cell differentiation (GO:0045577)3.73760853
54negative regulation of T cell apoptotic process (GO:0070233)3.72563498
55positive regulation of tolerance induction (GO:0002645)3.71981187
56negative regulation of phagocytosis (GO:0050765)3.67735564
57respiratory burst (GO:0045730)3.66075424
58positive regulation of T cell chemotaxis (GO:0010820)3.65444677
59regulation of T cell chemotaxis (GO:0010819)3.65444677
60regulation of T cell receptor signaling pathway (GO:0050856)3.63679003
61negative regulation of type 2 immune response (GO:0002829)3.60216709
62Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58152445
63immunoglobulin mediated immune response (GO:0016064)3.58027214
64positive regulation of cell killing (GO:0031343)3.53359414
65regulation of tolerance induction (GO:0002643)3.52835077
66dendritic cell chemotaxis (GO:0002407)3.51504094
67antigen receptor-mediated signaling pathway (GO:0050851)3.50716269
68cellular defense response (GO:0006968)3.50667411
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50179881
70positive regulation of monocyte chemotaxis (GO:0090026)3.50166529
71regulation of isotype switching to IgG isotypes (GO:0048302)3.45414758
72negative regulation of T cell mediated immunity (GO:0002710)3.40309849
73positive regulation of granulocyte differentiation (GO:0030854)3.40250083
74natural killer cell differentiation (GO:0001779)3.39716190
75negative regulation of lymphocyte mediated immunity (GO:0002707)3.36150961
76muscle atrophy (GO:0014889)3.34642276
77regulation of cell killing (GO:0031341)3.34197751
78negative regulation of stress fiber assembly (GO:0051497)3.33063078
79regulation of calcium-mediated signaling (GO:0050848)3.31902420
80T cell costimulation (GO:0031295)3.31668247
81regulation of interleukin-2 biosynthetic process (GO:0045076)3.27836119
82lymphocyte costimulation (GO:0031294)3.27477586
83purine deoxyribonucleotide catabolic process (GO:0009155)3.25585392
84positive regulation of T cell mediated cytotoxicity (GO:0001916)3.19986539
85positive regulation of T cell migration (GO:2000406)3.18930577
86B cell receptor signaling pathway (GO:0050853)3.18461904
87positive regulation of T cell differentiation in thymus (GO:0033089)3.13913707
88regulation of activation of Janus kinase activity (GO:0010533)3.10678924
89activated T cell proliferation (GO:0050798)3.09765526
90negative regulation of glycoprotein biosynthetic process (GO:0010561)3.08708287
91positive regulation of lymphocyte migration (GO:2000403)3.07494939
92positive regulation of endothelial cell differentiation (GO:0045603)3.06699834
93dendritic cell migration (GO:0036336)3.06269640
94positive regulation of natural killer cell differentiation (GO:0032825)3.06249947
95antigen processing and presentation via MHC class Ib (GO:0002475)3.04297018
96B cell mediated immunity (GO:0019724)3.03109726
97positive regulation of interleukin-4 production (GO:0032753)3.02519911
98regulation of T cell mediated cytotoxicity (GO:0001914)3.01758516
99positive regulation of interleukin-17 production (GO:0032740)2.98801124
100positive regulation of lamellipodium organization (GO:1902745)2.97738477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.21038776
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.87581953
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.24839222
4ELF1_17652178_ChIP-ChIP_JURKAT_Human4.95564527
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.57128020
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.50206948
7RUNX_20019798_ChIP-Seq_JUKART_Human3.51419740
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.36425292
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.33529807
10MYB_26560356_Chip-Seq_TH2_Human3.23587916
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.04510792
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92568994
13UTX_26944678_Chip-Seq_JUKART_Human2.89586428
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79242811
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78784630
16MYB_26560356_Chip-Seq_TH1_Human2.70003832
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56621158
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56105094
19GATA3_27048872_Chip-Seq_THYMUS_Human2.51649652
20MAF_26560356_Chip-Seq_TH1_Human2.41830489
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.31752042
22SPI1_23547873_ChIP-Seq_NB4_Human2.22651183
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.19463308
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13284156
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.10175173
26MAF_26560356_Chip-Seq_TH2_Human2.06339495
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.01679951
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00749085
29GATA3_26560356_Chip-Seq_TH2_Human1.95101438
30CIITA_25753668_ChIP-Seq_RAJI_Human1.75482963
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74770326
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.69853199
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66709766
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65759869
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65377512
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60672688
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56733911
38SPI1_23127762_ChIP-Seq_K562_Human1.56538974
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54085520
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53905818
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52495789
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51375732
43VDR_23849224_ChIP-Seq_CD4+_Human1.48631017
44VDR_21846776_ChIP-Seq_THP-1_Human1.44809584
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43837840
46VDR_24763502_ChIP-Seq_THP-1_Human1.43759598
47FOXP3_21729870_ChIP-Seq_TREG_Human1.42519663
48SCL_19346495_ChIP-Seq_HPC-7_Human1.34840144
49MYC_22102868_ChIP-Seq_BL_Human1.30876521
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27538729
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.21487296
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19574464
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.18299442
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16809707
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14309373
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12785381
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11916501
58TCF7_22412390_ChIP-Seq_EML_Mouse1.10643144
59BCL6_27268052_Chip-Seq_Bcells_Human1.09863270
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08373492
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07869176
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07549815
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05816273
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02986278
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.02605603
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01138920
67GABP_17652178_ChIP-ChIP_JURKAT_Human0.97522789
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94792598
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94178054
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93923551
71BCOR_27268052_Chip-Seq_Bcells_Human0.90444458
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90410735
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87686961
74GATA3_26560356_Chip-Seq_TH1_Human0.86310526
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85994536
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85144240
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84824987
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.84080319
79PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83705964
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81707274
81YY1_21170310_ChIP-Seq_MESCs_Mouse0.81419827
82SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79299083
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78721873
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77644357
85PU_27001747_Chip-Seq_BMDM_Mouse0.76041572
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75118716
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73000509
88FLI1_21867929_ChIP-Seq_CD8_Mouse0.72385749
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71934799
90KDM2B_26808549_Chip-Seq_DND41_Human0.71881891
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71843790
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70249621
93ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69706130
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.69243146
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68828099
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67439166
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67018485
98SPI1_20517297_ChIP-Seq_HL60_Human0.66807915
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66706049
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.66545769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.86673274
2MP0009785_altered_susceptibility_to3.97691933
3MP0003763_abnormal_thymus_physiology3.70857491
4MP0001835_abnormal_antigen_presentation3.70786539
5MP0000685_abnormal_immune_system3.10382114
6MP0001800_abnormal_humoral_immune3.07451771
7MP0005387_immune_system_phenotype3.00470826
8MP0001790_abnormal_immune_system3.00470826
9MP0002166_altered_tumor_susceptibility2.99923393
10MP0005025_abnormal_response_to2.96966173
11MP0003724_increased_susceptibility_to2.96847274
12MP0005000_abnormal_immune_tolerance2.96495805
13MP0003866_abnormal_defecation2.83838778
14MP0002420_abnormal_adaptive_immunity2.79866106
15MP0001819_abnormal_immune_cell2.71442393
16MP0009333_abnormal_splenocyte_physiolog2.70518245
17MP0002723_abnormal_immune_serum2.53591531
18MP0002148_abnormal_hypersensitivity_rea2.46802433
19MP0003436_decreased_susceptibility_to2.46668192
20MP0002452_abnormal_antigen_presenting2.40291406
21MP0006082_CNS_inflammation2.31222104
22MP0003045_fibrosis2.28847086
23MP0002419_abnormal_innate_immunity2.25775790
24MP0002398_abnormal_bone_marrow2.24624523
25MP0003448_altered_tumor_morphology2.21814131
26MP0010155_abnormal_intestine_physiology2.21766679
27MP0000703_abnormal_thymus_morphology2.19152500
28MP0002405_respiratory_system_inflammati2.16867812
29MP0000716_abnormal_immune_system2.09924934
30MP0002006_tumorigenesis2.05444919
31MP0003011_delayed_dark_adaptation1.89955472
32MP0002722_abnormal_immune_system1.86976599
33MP0000689_abnormal_spleen_morphology1.86856938
34MP0001845_abnormal_inflammatory_respons1.78130482
35MP0003300_gastrointestinal_ulcer1.75251148
36MP0001873_stomach_inflammation1.75216902
37MP0002429_abnormal_blood_cell1.64906601
38MP0004947_skin_inflammation1.63928145
39MP0005464_abnormal_platelet_physiology1.62040583
40MP0002933_joint_inflammation1.56357154
41MP0008469_abnormal_protein_level1.50621613
42MP0005166_decreased_susceptibility_to1.43645488
43MP0000465_gastrointestinal_hemorrhage1.43354648
44MP0004381_abnormal_hair_follicle1.42071537
45MP0002277_abnormal_respiratory_mucosa1.31375829
46MP0000858_altered_metastatic_potential1.27502572
47MP0003191_abnormal_cellular_cholesterol1.24245053
48MP0000490_abnormal_crypts_of1.22120007
49MP0003303_peritoneal_inflammation1.21921768
50MP0001533_abnormal_skeleton_physiology1.21655074
51MP0002009_preneoplasia1.17071268
52MP0009763_increased_sensitivity_to1.15235362
53MP0004883_abnormal_blood_vessel1.08494438
54MP0000604_amyloidosis1.06367534
55MP0001851_eye_inflammation1.06228333
56MP0008260_abnormal_autophagy0.99675506
57MP0003329_amyloid_beta_deposits0.97841980
58MP0005379_endocrine/exocrine_gland_phen0.95968824
59MP0008961_abnormal_basal_metabolism0.92441243
60MP0002693_abnormal_pancreas_physiology0.90727384
61MP0003690_abnormal_glial_cell0.86257229
62MP0002019_abnormal_tumor_incidence0.83948623
63MP0005075_abnormal_melanosome_morpholog0.83804996
64MP0005319_abnormal_enzyme/_coenzyme0.83752216
65MP0005310_abnormal_salivary_gland0.81899487
66MP0002998_abnormal_bone_remodeling0.81524555
67MP0002132_abnormal_respiratory_system0.80670417
68MP0005645_abnormal_hypothalamus_physiol0.78358476
69MP0009764_decreased_sensitivity_to0.76997425
70MP0002138_abnormal_hepatobiliary_system0.75592791
71MP0001853_heart_inflammation0.74333086
72MP0002396_abnormal_hematopoietic_system0.73326930
73MP0004145_abnormal_muscle_electrophysio0.73260595
74MP0001542_abnormal_bone_strength0.73228894
75MP0002168_other_aberrant_phenotype0.71948628
76MP0002139_abnormal_hepatobiliary_system0.71818462
77MP0003137_abnormal_impulse_conducting0.67412544
78MP0009643_abnormal_urine_homeostasis0.66696930
79MP0008873_increased_physiological_sensi0.65640643
80MP0005164_abnormal_response_to0.55910979
81MP0003183_abnormal_peptide_metabolism0.55758843
82MP0000343_altered_response_to0.54257482
83MP0000920_abnormal_myelination0.49348512
84MP0002163_abnormal_gland_morphology0.47966361
85MP0001765_abnormal_ion_homeostasis0.47827116
86MP0003868_abnormal_feces_composition0.47409904
87MP0003252_abnormal_bile_duct0.47336776
88MP0004510_myositis0.46568824
89MP0002136_abnormal_kidney_physiology0.45670030
90MP0001986_abnormal_taste_sensitivity0.44294840
91MP0001727_abnormal_embryo_implantation0.44205870
92MP0003795_abnormal_bone_structure0.43929064
93MP0003172_abnormal_lysosome_physiology0.43170018
94MP0001919_abnormal_reproductive_system0.42058629
95MP0000249_abnormal_blood_vessel0.41899720
96MP0005058_abnormal_lysosome_morphology0.41843543
97MP0009642_abnormal_blood_homeostasis0.40078520
98MP0001905_abnormal_dopamine_level0.37936543
99MP0001663_abnormal_digestive_system0.37418405
100MP0000313_abnormal_cell_death0.36156153

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.71491617
2Aplastic anemia (HP:0001915)6.59431476
3Abnormality of T cell number (HP:0011839)5.94121757
4Increased IgM level (HP:0003496)5.38455778
5Stomatitis (HP:0010280)5.27138310
6Autoimmune hemolytic anemia (HP:0001890)5.18547919
7Spontaneous hematomas (HP:0007420)5.13214309
8Elevated erythrocyte sedimentation rate (HP:0003565)5.03231955
9IgG deficiency (HP:0004315)4.86196792
10Acute hepatic failure (HP:0006554)4.77984829
11Severe combined immunodeficiency (HP:0004430)4.77814830
12Abnormality of T cells (HP:0002843)4.60779886
13Chronic diarrhea (HP:0002028)4.43079056
14Myositis (HP:0100614)4.22311568
15Encephalitis (HP:0002383)3.99138287
16Abnormality of macrophages (HP:0004311)3.97499880
17Pustule (HP:0200039)3.93753440
18Recurrent abscess formation (HP:0002722)3.83054913
19Eczematoid dermatitis (HP:0000976)3.78768582
20Combined immunodeficiency (HP:0005387)3.77579147
21Recurrent bacterial skin infections (HP:0005406)3.71057477
22Hypoproteinemia (HP:0003075)3.56366857
23Hypergammaglobulinemia (HP:0010702)3.55825568
24Recurrent viral infections (HP:0004429)3.50038041
25Meningitis (HP:0001287)3.39037042
26Thyroiditis (HP:0100646)3.29935830
27Recurrent fungal infections (HP:0002841)3.27552724
28Pancytopenia (HP:0001876)3.18365966
29Recurrent bronchitis (HP:0002837)3.07703639
30Panhypogammaglobulinemia (HP:0003139)3.06046429
31Abnormality of eosinophils (HP:0001879)3.01638255
32Lymphoma (HP:0002665)3.00204795
33Recurrent cutaneous fungal infections (HP:0011370)2.99576680
34Chronic mucocutaneous candidiasis (HP:0002728)2.99576680
35Increased IgE level (HP:0003212)2.95813199
36Obstructive lung disease (HP:0006536)2.94445303
37Chronic obstructive pulmonary disease (HP:0006510)2.94445303
38IgM deficiency (HP:0002850)2.94100048
39Cellular immunodeficiency (HP:0005374)2.93187592
40Lymphopenia (HP:0001888)2.85448279
41Agammaglobulinemia (HP:0004432)2.82835296
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.81438246
43Tetany (HP:0001281)2.80795826
44Inflammation of the large intestine (HP:0002037)2.79979534
45Cerebral palsy (HP:0100021)2.78439864
46Microcytic anemia (HP:0001935)2.77573401
47Leukocytosis (HP:0001974)2.76537354
48Recurrent skin infections (HP:0001581)2.68697905
49Broad face (HP:0000283)2.68232849
50Eosinophilia (HP:0001880)2.67750175
51Hypoplasia of the thymus (HP:0000778)2.65917119
52B lymphocytopenia (HP:0010976)2.63731831
53Abnormality of B cell number (HP:0010975)2.62386174
54Gastrointestinal inflammation (HP:0004386)2.62290836
55Retrobulbar optic neuritis (HP:0100654)2.61793106
56Optic neuritis (HP:0100653)2.61793106
57Birth length less than 3rd percentile (HP:0003561)2.60278330
58Petechiae (HP:0000967)2.59706739
59Abnormality of T cell physiology (HP:0011840)2.59583661
60Hypochromic microcytic anemia (HP:0004840)2.58729387
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.57837851
62Granulocytopenia (HP:0001913)2.51261410
63Long clavicles (HP:0000890)2.47012591
64Mediastinal lymphadenopathy (HP:0100721)2.45132966
65Oral leukoplakia (HP:0002745)2.43913668
66Orchitis (HP:0100796)2.40639023
67Conjunctival telangiectasia (HP:0000524)2.34354844
68Symptomatic seizures (HP:0011145)2.32115153
69Aplasia/Hypoplasia of the thymus (HP:0010515)2.31708782
70Epistaxis (HP:0000421)2.25426619
71Spinal canal stenosis (HP:0003416)2.25175186
72Pulmonary embolism (HP:0002204)2.24514387
73Hemoptysis (HP:0002105)2.23215631
74Alveolar cell carcinoma (HP:0006519)2.14864613
75Autoimmune thrombocytopenia (HP:0001973)2.12794971
76Colitis (HP:0002583)2.12559452
77Vasculitis (HP:0002633)2.10952999
78Recurrent gram-negative bacterial infections (HP:0005420)2.09901874
79Keratoconjunctivitis sicca (HP:0001097)2.08157455
80Hypochromic anemia (HP:0001931)2.06989929
81Hypoparathyroidism (HP:0000829)2.04395338
823-Methylglutaconic aciduria (HP:0003535)2.01580019
83Gastrointestinal infarctions (HP:0005244)1.96967972
84Keratoconjunctivitis (HP:0001096)1.95973760
85Pulmonary infiltrates (HP:0002113)1.94734386
86Neoplasm of the tracheobronchial system (HP:0100552)1.94034938
87Hemiplegia (HP:0002301)1.91589805
88Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89464633
89Bronchitis (HP:0012387)1.86797468
90Hypomagnesemia (HP:0002917)1.84762221
91Purpura (HP:0000979)1.84091006
92Nasal polyposis (HP:0100582)1.83155556
93Prolonged bleeding time (HP:0003010)1.82208259
94Papilledema (HP:0001085)1.78860091
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78414085
96Seborrheic dermatitis (HP:0001051)1.78043777
97Urticaria (HP:0001025)1.77961952
98Sepsis (HP:0100806)1.72881165
99Gingivitis (HP:0000230)1.71750034
100Amyotrophic lateral sclerosis (HP:0007354)1.71294027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.19030461
2TXK4.23340614
3TESK23.87308818
4MAP4K13.50357887
5GRK73.46666162
6FES2.61975440
7ITK2.53517453
8MAP3K122.48372995
9RIPK42.41931430
10TAF12.40020540
11BTK2.31366307
12TGFBR22.25448427
13STK102.24802759
14GRK62.13158337
15TAOK32.08760893
16MOS2.02230570
17TESK11.98736515
18CSK1.90941947
19TBK11.67665472
20HCK1.60774339
21JAK31.59915836
22LCK1.59488258
23CLK11.57283525
24ZAP701.56331301
25PASK1.46985252
26SYK1.42263055
27TEC1.37294853
28MST41.32298010
29TNK21.28373342
30TYK21.25060400
31GRK51.24184944
32PRKCH1.23842902
33JAK21.23445665
34LYN1.22317333
35IKBKE1.20871592
36EPHB11.16849925
37MAP3K111.11252269
38SIK31.10168028
39MYLK1.01255410
40IRAK40.99907023
41CAMKK20.98331669
42CSF1R0.97535844
43BMPR20.95130688
44NLK0.93663457
45ERN10.93519455
46PRKCQ0.91166089
47MARK30.89080095
48PDK10.88868699
49EIF2AK30.88654407
50FGR0.85759439
51DAPK10.78409127
52CDK40.77192639
53SCYL20.77144915
54PTK60.77113430
55NTRK20.76795261
56BLK0.74387221
57JAK10.73041761
58NEK60.72947527
59STK390.71151944
60MAPK110.70768447
61MAP2K30.70606958
62BCKDK0.69720223
63MAP3K30.69290815
64ILK0.64324907
65WNK40.61701497
66FYN0.60867426
67LIMK10.60412115
68RPS6KA40.55626336
69PRPF4B0.54887120
70IKBKB0.53742045
71HIPK20.52823610
72KIT0.49317385
73TAOK10.48814868
74AURKA0.46512543
75TAOK20.46191775
76PAK10.44959831
77MAPKAPK20.44540733
78SIK20.44217471
79CAMKK10.43769750
80PIM10.43450618
81MAP2K60.38742382
82MAPK130.38107723
83TRPM70.37362585
84MAP2K20.36442179
85MAP3K50.35192500
86FGFR40.31597176
87IGF1R0.30546064
88INSR0.29558926
89MAP3K70.27862672
90MAP3K140.27554297
91PAK40.26437869
92STK380.24568598
93TYRO30.21449027
94RPS6KA50.21147974
95ADRBK10.20885282
96PRKD20.20723353
97ADRBK20.19930549
98MAPKAPK30.19894297
99MAP3K10.19784583
100PIK3CG0.19471272

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.56683727
2T cell receptor signaling pathway_Homo sapiens_hsa046603.43005897
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.28763391
4Antigen processing and presentation_Homo sapiens_hsa046123.22770853
5Hematopoietic cell lineage_Homo sapiens_hsa046403.00150728
6Graft-versus-host disease_Homo sapiens_hsa053322.86755229
7Proteasome_Homo sapiens_hsa030502.76128105
8Autoimmune thyroid disease_Homo sapiens_hsa053202.69387729
9Allograft rejection_Homo sapiens_hsa053302.63112954
10Measles_Homo sapiens_hsa051622.36780482
11Type I diabetes mellitus_Homo sapiens_hsa049401.92891594
12Shigellosis_Homo sapiens_hsa051311.85959790
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77281319
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.58105147
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.56228884
16Viral myocarditis_Homo sapiens_hsa054161.55098191
17Chemokine signaling pathway_Homo sapiens_hsa040621.54950469
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54418669
19Salmonella infection_Homo sapiens_hsa051321.53874789
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52524608
21Leishmaniasis_Homo sapiens_hsa051401.52216429
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51247549
23Osteoclast differentiation_Homo sapiens_hsa043801.49990754
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46614667
25Malaria_Homo sapiens_hsa051441.45372383
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38651077
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33888712
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21016413
29Oxidative phosphorylation_Homo sapiens_hsa001901.16891257
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.16267695
31Herpes simplex infection_Homo sapiens_hsa051681.15801793
32Regulation of autophagy_Homo sapiens_hsa041401.15036442
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12818699
34Staphylococcus aureus infection_Homo sapiens_hsa051501.12403374
35Parkinsons disease_Homo sapiens_hsa050121.10671871
36B cell receptor signaling pathway_Homo sapiens_hsa046621.09514674
37Platelet activation_Homo sapiens_hsa046111.04340997
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02516719
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99225823
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.97516721
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93792117
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92844335
43Tuberculosis_Homo sapiens_hsa051520.91471147
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85937919
45Influenza A_Homo sapiens_hsa051640.83161574
46Pertussis_Homo sapiens_hsa051330.81076654
47Legionellosis_Homo sapiens_hsa051340.77050192
48Alzheimers disease_Homo sapiens_hsa050100.75842960
49Asthma_Homo sapiens_hsa053100.75762816
50Endocytosis_Homo sapiens_hsa041440.75051445
51TNF signaling pathway_Homo sapiens_hsa046680.74379129
52Apoptosis_Homo sapiens_hsa042100.74202155
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70918649
54Rheumatoid arthritis_Homo sapiens_hsa053230.70670608
55Acute myeloid leukemia_Homo sapiens_hsa052210.70190545
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69743850
57Caffeine metabolism_Homo sapiens_hsa002320.69061455
58HTLV-I infection_Homo sapiens_hsa051660.68876065
59Toxoplasmosis_Homo sapiens_hsa051450.60419087
60Epstein-Barr virus infection_Homo sapiens_hsa051690.59964758
61Viral carcinogenesis_Homo sapiens_hsa052030.59636418
62Hepatitis B_Homo sapiens_hsa051610.59587098
63African trypanosomiasis_Homo sapiens_hsa051430.58281997
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55991589
65Ribosome_Homo sapiens_hsa030100.55982238
66Huntingtons disease_Homo sapiens_hsa050160.50911988
67Non-small cell lung cancer_Homo sapiens_hsa052230.49233450
68Non-homologous end-joining_Homo sapiens_hsa034500.48447192
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43523968
70Hepatitis C_Homo sapiens_hsa051600.40438499
71Renin secretion_Homo sapiens_hsa049240.39196585
72DNA replication_Homo sapiens_hsa030300.38429846
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37796900
74One carbon pool by folate_Homo sapiens_hsa006700.34477082
75Pancreatic cancer_Homo sapiens_hsa052120.32586097
76VEGF signaling pathway_Homo sapiens_hsa043700.29890499
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.28851140
78Cardiac muscle contraction_Homo sapiens_hsa042600.25648664
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24907426
80Olfactory transduction_Homo sapiens_hsa047400.24621844
81Peroxisome_Homo sapiens_hsa041460.24042020
82Nucleotide excision repair_Homo sapiens_hsa034200.22227337
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22194729
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.21411067
85Base excision repair_Homo sapiens_hsa034100.19228611
86Long-term potentiation_Homo sapiens_hsa047200.18014528
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17689455
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16016598
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15568338
90Phagosome_Homo sapiens_hsa041450.15469151
91Colorectal cancer_Homo sapiens_hsa052100.14495473
92Mismatch repair_Homo sapiens_hsa034300.13015953
93Systemic lupus erythematosus_Homo sapiens_hsa053220.10255177
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10206234
95MAPK signaling pathway_Homo sapiens_hsa040100.09138536
96Rap1 signaling pathway_Homo sapiens_hsa040150.08101812
97FoxO signaling pathway_Homo sapiens_hsa040680.07559048
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.07054587
99ABC transporters_Homo sapiens_hsa020100.06038863
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.05463676

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