TRBV4-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)8.27843852
2cytidine deamination (GO:0009972)8.27843852
3cytidine metabolic process (GO:0046087)8.27843852
4regulation of B cell receptor signaling pathway (GO:0050855)7.92681542
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.74690056
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.66080329
7DNA deamination (GO:0045006)7.57507523
8T cell migration (GO:0072678)7.56196528
9positive regulation of interleukin-8 secretion (GO:2000484)6.95997715
10regulation of lymphocyte chemotaxis (GO:1901623)6.49371288
11regulation of interleukin-12 biosynthetic process (GO:0045075)6.22630986
12positive regulation of monocyte chemotaxis (GO:0090026)6.22297128
13negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.12257409
14positive regulation of lymphocyte migration (GO:2000403)5.97453433
15viral genome replication (GO:0019079)5.79664544
16negative regulation of T cell receptor signaling pathway (GO:0050860)5.70616342
17chemokine-mediated signaling pathway (GO:0070098)5.60220477
18negative regulation by host of viral transcription (GO:0043922)5.43800435
19regulation of T cell receptor signaling pathway (GO:0050856)5.38397929
20lymphocyte chemotaxis (GO:0048247)5.34078273
21cellular response to interleukin-15 (GO:0071350)5.28925232
22eosinophil chemotaxis (GO:0048245)5.08350932
23regulation of antigen receptor-mediated signaling pathway (GO:0050854)5.06915216
24tolerance induction (GO:0002507)4.88388424
25response to interleukin-15 (GO:0070672)4.82639892
26regulation of lymphocyte migration (GO:2000401)4.78765825
27regulation of T cell chemotaxis (GO:0010819)4.77202722
28positive regulation of T cell chemotaxis (GO:0010820)4.77202722
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.72006184
30regulation of interleukin-8 secretion (GO:2000482)4.59685470
31eosinophil migration (GO:0072677)4.57278264
32CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.56649328
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.46571729
34positive regulation of natural killer cell mediated immunity (GO:0002717)4.43228064
35Arp2/3 complex-mediated actin nucleation (GO:0034314)4.42214715
36positive regulation of T cell migration (GO:2000406)4.30942085
37lymphocyte migration (GO:0072676)4.27043864
38regulation of activation of Janus kinase activity (GO:0010533)4.26269247
39regulation of monocyte chemotaxis (GO:0090025)4.21662083
40ncRNA 3-end processing (GO:0043628)4.21315467
41regulation of T cell migration (GO:2000404)4.17506281
42negative regulation of execution phase of apoptosis (GO:1900118)4.17026727
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.13195288
44positive regulation of defense response to virus by host (GO:0002230)4.12665945
45T cell receptor signaling pathway (GO:0050852)4.11327216
46positive regulation of calcium-mediated signaling (GO:0050850)4.08152747
47antigen receptor-mediated signaling pathway (GO:0050851)4.05072693
48signal complex assembly (GO:0007172)3.92558856
49T cell costimulation (GO:0031295)3.90567113
50macrophage chemotaxis (GO:0048246)3.90400721
51lymphocyte costimulation (GO:0031294)3.85418868
52lymph node development (GO:0048535)3.83500984
53dendritic cell chemotaxis (GO:0002407)3.79452020
54interferon-gamma production (GO:0032609)3.79333752
55regulation of isotype switching to IgG isotypes (GO:0048302)3.75550899
56negative regulation of type 2 immune response (GO:0002829)3.69664188
57negative regulation of bone resorption (GO:0045779)3.66005403
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.64488710
59regulation of natural killer cell mediated immunity (GO:0002715)3.64488710
60regulation of regulatory T cell differentiation (GO:0045589)3.60829230
61actin nucleation (GO:0045010)3.55590296
62regulation of chronic inflammatory response (GO:0002676)3.54296741
63mast cell activation (GO:0045576)3.53151171
64positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.49714355
65production of molecular mediator involved in inflammatory response (GO:0002532)3.48276198
66proteasome assembly (GO:0043248)3.43339768
67positive regulation of gamma-delta T cell activation (GO:0046645)3.41950390
68regulation of calcium-mediated signaling (GO:0050848)3.37440301
69adaptation of signaling pathway (GO:0023058)3.34467457
70pyrimidine nucleoside catabolic process (GO:0046135)3.34280281
71negative regulation of calcium ion transport into cytosol (GO:0010523)3.32464486
72dendritic cell migration (GO:0036336)3.31732860
73positive thymic T cell selection (GO:0045059)3.26036468
74negative regulation of T cell apoptotic process (GO:0070233)3.24918397
75regulation of translation in response to stress (GO:0043555)3.19817432
76regulation of leukocyte mediated cytotoxicity (GO:0001910)3.19149443
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15584684
78positive T cell selection (GO:0043368)3.15382557
79positive regulation of alpha-beta T cell proliferation (GO:0046641)3.15253202
80regulation of B cell differentiation (GO:0045577)3.13486847
81mitotic G1 DNA damage checkpoint (GO:0031571)3.12280656
82myeloid dendritic cell activation (GO:0001773)3.11825573
83positive regulation of cell killing (GO:0031343)3.11436163
84negative regulation of viral transcription (GO:0032897)3.07757134
85negative regulation of viral genome replication (GO:0045071)3.04524704
86mitotic G1/S transition checkpoint (GO:0044819)3.00693224
87positive regulation of T cell apoptotic process (GO:0070234)2.99723494
88B cell receptor signaling pathway (GO:0050853)2.94806125
89cellular defense response (GO:0006968)2.93827885
90defense response to protozoan (GO:0042832)2.93290134
91negative regulation of bone remodeling (GO:0046851)2.92594394
92negative regulation of leukocyte mediated immunity (GO:0002704)2.91801532
93regulation of gamma-delta T cell differentiation (GO:0045586)2.85667419
94regulation of interleukin-2 biosynthetic process (GO:0045076)2.85597540
95regulation of cell killing (GO:0031341)2.85142091
96T cell lineage commitment (GO:0002360)2.84480249
97granulocyte activation (GO:0036230)2.84073925
98T cell differentiation (GO:0030217)2.84009736
99iron-sulfur cluster assembly (GO:0016226)2.80499505
100metallo-sulfur cluster assembly (GO:0031163)2.80499505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.25650882
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.21842700
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.71730884
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53051545
5GATA1_22025678_ChIP-Seq_K562_Human4.06640295
6RUNX_20019798_ChIP-Seq_JUKART_Human3.83350770
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53297099
8MYB_26560356_Chip-Seq_TH2_Human3.35701201
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31683017
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.00350299
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.91426785
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.74511896
13GATA3_27048872_Chip-Seq_THYMUS_Human2.43603188
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41565208
15MYB_26560356_Chip-Seq_TH1_Human2.36899219
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34610394
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26638563
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17127801
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.14524483
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11777326
21BP1_19119308_ChIP-ChIP_Hs578T_Human10.2558266
22UTX_26944678_Chip-Seq_JUKART_Human1.98331710
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90911590
24MAF_26560356_Chip-Seq_TH1_Human1.78703856
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76002083
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.73609128
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.72891203
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72430172
29MAF_26560356_Chip-Seq_TH2_Human1.64954826
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63087303
31GATA3_26560356_Chip-Seq_TH2_Human1.59845025
32SPI1_23547873_ChIP-Seq_NB4_Human1.57725260
33VDR_23849224_ChIP-Seq_CD4+_Human1.55184188
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51690270
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.51008073
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.34153484
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32529969
38CIITA_25753668_ChIP-Seq_RAJI_Human1.31342350
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29520580
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28744015
41RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.28134894
42FOXP3_21729870_ChIP-Seq_TREG_Human1.27591721
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.27456500
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24499164
45TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23899979
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22396755
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15555462
48BCL6_27268052_Chip-Seq_Bcells_Human1.14751408
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10768906
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09842245
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07461939
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06747358
53MYC_22102868_ChIP-Seq_BL_Human1.02986807
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.01658376
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97730935
56P300_27268052_Chip-Seq_Bcells_Human0.97355801
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96651230
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96619684
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96576784
60GABP_17652178_ChIP-ChIP_JURKAT_Human0.95418279
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95072237
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94034470
63HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92731122
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90953468
65GATA3_21867929_ChIP-Seq_TH1_Mouse0.90610838
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90589801
67GATA3_26560356_Chip-Seq_TH1_Human0.90078397
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89328919
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87539583
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86938698
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86509530
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86375550
73ETS1_20019798_ChIP-Seq_JURKAT_Human0.86258976
74TAF2_19829295_ChIP-Seq_ESCs_Human0.83782433
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83623602
76GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83032701
77MYC_18940864_ChIP-ChIP_HL60_Human0.82812167
78IRF1_19129219_ChIP-ChIP_H3396_Human0.82613996
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82532317
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80562957
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.80517261
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79264576
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78704269
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.78294673
85CTCF_20526341_ChIP-Seq_ESCs_Human0.78111218
86BCOR_27268052_Chip-Seq_Bcells_Human0.77916654
87SPI1_23127762_ChIP-Seq_K562_Human0.77699407
88RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75072579
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.73505341
90TAF15_26573619_Chip-Seq_HEK293_Human0.73265829
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71984344
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70940436
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.70850831
94FLI1_21867929_ChIP-Seq_CD8_Mouse0.68901689
95FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.66965823
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66952095
97ERA_21632823_ChIP-Seq_H3396_Human0.66853224
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.66819677
99NCOR_22424771_ChIP-Seq_293T_Human0.64657213
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.63948516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.74448465
2MP0009785_altered_susceptibility_to4.63921189
3MP0003763_abnormal_thymus_physiology4.22404928
4MP0009333_abnormal_splenocyte_physiolog3.28237958
5MP0003866_abnormal_defecation3.24688876
6MP0001800_abnormal_humoral_immune3.19011444
7MP0001835_abnormal_antigen_presentation3.13967177
8MP0006082_CNS_inflammation3.09457084
9MP0005000_abnormal_immune_tolerance3.01726211
10MP0002148_abnormal_hypersensitivity_rea3.00465296
11MP0005025_abnormal_response_to2.80376383
12MP0002723_abnormal_immune_serum2.57278859
13MP0002420_abnormal_adaptive_immunity2.51401153
14MP0001819_abnormal_immune_cell2.45381589
15MP0003436_decreased_susceptibility_to2.44688668
16MP0002405_respiratory_system_inflammati2.41642256
17MP0000604_amyloidosis2.25727123
18MP0003045_fibrosis2.23385688
19MP0002452_abnormal_antigen_presenting2.09274749
20MP0010155_abnormal_intestine_physiology2.06405279
21MP0001790_abnormal_immune_system2.01587029
22MP0005387_immune_system_phenotype2.01587029
23MP0000703_abnormal_thymus_morphology2.01143017
24MP0000569_abnormal_digit_pigmentation2.00417593
25MP0005058_abnormal_lysosome_morphology1.95889600
26MP0000689_abnormal_spleen_morphology1.91062531
27MP0002398_abnormal_bone_marrow1.89791815
28MP0003880_abnormal_central_pattern1.86784512
29MP0000716_abnormal_immune_system1.85483060
30MP0002722_abnormal_immune_system1.85141359
31MP0001845_abnormal_inflammatory_respons1.83970080
32MP0003329_amyloid_beta_deposits1.82298848
33MP0005166_decreased_susceptibility_to1.78124089
34MP0000685_abnormal_immune_system1.72517898
35MP0003448_altered_tumor_morphology1.69917033
36MP0002419_abnormal_innate_immunity1.68601283
37MP0003172_abnormal_lysosome_physiology1.65294600
38MP0003183_abnormal_peptide_metabolism1.51140726
39MP0004381_abnormal_hair_follicle1.47103033
40MP0002429_abnormal_blood_cell1.42836594
41MP0008260_abnormal_autophagy1.40164263
42MP0002693_abnormal_pancreas_physiology1.35715651
43MP0002166_altered_tumor_susceptibility1.34083411
44MP0003806_abnormal_nucleotide_metabolis1.31754034
45MP0003690_abnormal_glial_cell1.28361929
46MP0008469_abnormal_protein_level1.28159899
47MP0003300_gastrointestinal_ulcer1.26806638
48MP0005464_abnormal_platelet_physiology1.23525482
49MP0009764_decreased_sensitivity_to1.20284201
50MP0009763_increased_sensitivity_to1.17377311
51MP0002277_abnormal_respiratory_mucosa1.16579216
52MP0002876_abnormal_thyroid_physiology1.02425133
53MP0004233_abnormal_muscle_weight1.01510402
54MP0006054_spinal_hemorrhage1.01300467
55MP0002998_abnormal_bone_remodeling1.00981028
56MP0004036_abnormal_muscle_relaxation0.99054810
57MP0002006_tumorigenesis0.99040540
58MP0001666_abnormal_nutrient_absorption0.94568441
59MP0001984_abnormal_olfaction0.90283924
60MP0010386_abnormal_urinary_bladder0.89280023
61MP0002877_abnormal_melanocyte_morpholog0.89093107
62MP0002019_abnormal_tumor_incidence0.88879520
63MP0001764_abnormal_homeostasis0.88201046
64MP0009765_abnormal_xenobiotic_induced0.86901119
65MP0001533_abnormal_skeleton_physiology0.85107051
66MP0001502_abnormal_circadian_rhythm0.82176261
67MP0004883_abnormal_blood_vessel0.80934161
68MP0003137_abnormal_impulse_conducting0.80140739
69MP0004782_abnormal_surfactant_physiolog0.80140655
70MP0005075_abnormal_melanosome_morpholog0.77847869
71MP0003693_abnormal_embryo_hatching0.76581973
72MP0002933_joint_inflammation0.76227681
73MP0000858_altered_metastatic_potential0.73523225
74MP0000477_abnormal_intestine_morphology0.73283405
75MP0002168_other_aberrant_phenotype0.73034965
76MP0009643_abnormal_urine_homeostasis0.72913613
77MP0001188_hyperpigmentation0.72597333
78MP0002163_abnormal_gland_morphology0.72568165
79MP0004145_abnormal_muscle_electrophysio0.71677034
80MP0002095_abnormal_skin_pigmentation0.71142165
81MP0004947_skin_inflammation0.70956729
82MP0001851_eye_inflammation0.69314697
83MP0003724_increased_susceptibility_to0.66803968
84MP0002136_abnormal_kidney_physiology0.62911423
85MP0003567_abnormal_fetal_cardiomyocyte0.62499918
86MP0003795_abnormal_bone_structure0.60521301
87MP0008873_increased_physiological_sensi0.58911229
88MP0001542_abnormal_bone_strength0.58795003
89MP0005319_abnormal_enzyme/_coenzyme0.58519236
90MP0001853_heart_inflammation0.58338059
91MP0003868_abnormal_feces_composition0.58121154
92MP0008007_abnormal_cellular_replicative0.57850387
93MP0001873_stomach_inflammation0.57066912
94MP0002083_premature_death0.55356959
95MP0005408_hypopigmentation0.53566793
96MP0004742_abnormal_vestibular_system0.50852107
97MP0000343_altered_response_to0.50736581
98MP0005174_abnormal_tail_pigmentation0.50465361
99MP0008877_abnormal_DNA_methylation0.49434244
100MP0005310_abnormal_salivary_gland0.49311763

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.18020422
2Stomatitis (HP:0010280)7.13726856
3Abnormality of T cell number (HP:0011839)6.49491214
4Abnormality of T cells (HP:0002843)5.52329530
5IgG deficiency (HP:0004315)5.51584641
6Recurrent bronchitis (HP:0002837)5.27879579
7IgM deficiency (HP:0002850)5.23062773
8Gastrointestinal infarctions (HP:0005244)5.13276055
9Severe combined immunodeficiency (HP:0004430)4.68620594
10Abnormality of binocular vision (HP:0011514)4.45058487
11Diplopia (HP:0000651)4.45058487
12J-shaped sella turcica (HP:0002680)4.18164009
13Chronic mucocutaneous candidiasis (HP:0002728)4.16871695
14Recurrent cutaneous fungal infections (HP:0011370)4.16871695
15B lymphocytopenia (HP:0010976)4.16743938
16Abnormality of T cell physiology (HP:0011840)4.08900853
17Abnormality of B cell number (HP:0010975)4.05825537
18Mediastinal lymphadenopathy (HP:0100721)3.91630457
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.89347053
20Acute hepatic failure (HP:0006554)3.85995813
21Hypoplasia of the thymus (HP:0000778)3.81458391
22Combined immunodeficiency (HP:0005387)3.80422878
23Autoimmune hemolytic anemia (HP:0001890)3.72390376
24Recurrent bacterial skin infections (HP:0005406)3.71455512
25Thyroiditis (HP:0100646)3.66682941
26Agammaglobulinemia (HP:0004432)3.59639464
27Chronic diarrhea (HP:0002028)3.54144104
28Chronic obstructive pulmonary disease (HP:0006510)3.52231557
29Obstructive lung disease (HP:0006536)3.52231557
30Abnormality of the prostate (HP:0008775)3.42239275
31Aplastic anemia (HP:0001915)3.39710758
32Broad face (HP:0000283)3.35045967
33Abnormality of eosinophils (HP:0001879)3.30420043
34Recurrent skin infections (HP:0001581)3.25905376
35Bronchitis (HP:0012387)3.24131780
36Carpal bone hypoplasia (HP:0001498)3.24129063
37Elevated erythrocyte sedimentation rate (HP:0003565)3.20453832
38Meningitis (HP:0001287)3.18272365
39Ureteral stenosis (HP:0000071)3.03134929
40Recurrent fungal infections (HP:0002841)3.02085846
41Joint swelling (HP:0001386)2.92273949
42Recurrent abscess formation (HP:0002722)2.89628328
43Lymphopenia (HP:0001888)2.85087024
44Abnormality of the alveolar ridges (HP:0006477)2.80631962
45Abnormal tarsal ossification (HP:0008369)2.73510193
46Ureteral obstruction (HP:0006000)2.72239280
47Amaurosis fugax (HP:0100576)2.70988724
48Vasculitis (HP:0002633)2.64529274
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.64469744
50Cerebral hypomyelination (HP:0006808)2.64039349
51Leukocytosis (HP:0001974)2.63500719
52Poor speech (HP:0002465)2.57874335
53IgA deficiency (HP:0002720)2.56398112
54Abnormality of oral frenula (HP:0000190)2.55680397
55Increased IgM level (HP:0003496)2.55153221
56Recurrent viral infections (HP:0004429)2.54498984
57Abnormality of macrophages (HP:0004311)2.50746957
58Chest pain (HP:0100749)2.50047551
59Pustule (HP:0200039)2.48149035
60Premature graying of hair (HP:0002216)2.46566084
61Panhypogammaglobulinemia (HP:0003139)2.46543159
62Hypoproteinemia (HP:0003075)2.44283220
63Recurrent otitis media (HP:0000403)2.41874496
64Periodontitis (HP:0000704)2.41432466
65Hemiplegia (HP:0002301)2.40346338
66Aortic dissection (HP:0002647)2.37622606
67Pulmonary infiltrates (HP:0002113)2.36218057
68Lymphoma (HP:0002665)2.34606275
69Premature ovarian failure (HP:0008209)2.30078117
70Gangrene (HP:0100758)2.28443939
71Joint hemorrhage (HP:0005261)2.24551550
72Dysostosis multiplex (HP:0000943)2.17329667
73Delusions (HP:0000746)2.16667898
74Eosinophilia (HP:0001880)2.16547523
75Arterial thrombosis (HP:0004420)2.13833931
76Chronic hepatic failure (HP:0100626)2.11647417
77Renal cortical cysts (HP:0000803)2.08803440
78Hypoplasia of the odontoid process (HP:0003311)2.04052854
79Recurrent sinusitis (HP:0011108)2.03791064
80Deformed sella turcica (HP:0002681)2.01461836
81Palpitations (HP:0001962)1.99374937
82Gastrointestinal stroma tumor (HP:0100723)1.97829106
83Stomach cancer (HP:0012126)1.96646811
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95906266
85Encephalitis (HP:0002383)1.94576098
86Aplasia/Hypoplasia of the thymus (HP:0010515)1.92172498
87Eczematoid dermatitis (HP:0000976)1.87324261
88Gingivitis (HP:0000230)1.86991903
89Hemoptysis (HP:0002105)1.84984980
90Pulmonary embolism (HP:0002204)1.84655338
91Personality changes (HP:0000751)1.83412482
92Abnormal foot bone ossification (HP:0010675)1.81587158
93CNS hypomyelination (HP:0003429)1.80121876
94Abnormality of male internal genitalia (HP:0000022)1.79387647
95Premature loss of primary teeth (HP:0006323)1.77923424
96Congenital stationary night blindness (HP:0007642)1.77884672
97Granulocytopenia (HP:0001913)1.77461472
98Recurrent pneumonia (HP:0006532)1.77152328
99Anorexia (HP:0002039)1.75340783
100Alveolar cell carcinoma (HP:0006519)1.74845175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.78290730
2EIF2AK35.72784403
3MAP4K14.61511466
4BCKDK3.85809799
5EIF2AK13.77106242
6FES3.53302642
7ITK3.45504153
8KDR3.29270115
9TESK22.95264346
10MAPKAPK32.69668537
11PDK22.52508218
12TEC2.30637427
13BTK1.92253142
14TESK11.74298416
15LCK1.71290463
16PRKCH1.69703665
17CSK1.64376273
18PRKCQ1.61373184
19TNK21.55078017
20SYK1.54809829
21IRAK31.46519301
22LYN1.39371413
23HCK1.37313398
24MAP3K111.36269681
25JAK31.31554969
26TYRO31.20613197
27PRKD21.19642750
28NUAK11.13805771
29FYN1.12893869
30MAP3K121.05589900
31KIT0.98906044
32DAPK10.98105233
33ZAP700.97560818
34GRK70.84356552
35IGF1R0.79949038
36LIMK10.79258233
37CSF1R0.77296512
38ZAK0.75071498
39PIK3CG0.74500269
40INSR0.68592260
41GRK60.68011098
42SGK2230.66073304
43SGK4940.66073304
44RPS6KA40.63910518
45PRKCD0.62877134
46ABL10.62603580
47FGFR10.62178391
48DYRK20.61271183
49JAK10.59819395
50ADRBK20.57322110
51PRKD10.55572996
52MAPK110.52524175
53JAK20.52104403
54PTK2B0.51024761
55PDK10.50623183
56PRKCA0.50206235
57NME10.48849238
58GRK10.48792535
59MYLK0.47606942
60IKBKB0.44239081
61RIPK40.41684615
62MAPKAPK20.38777266
63SIK20.38396981
64MARK30.37754693
65CDK40.36192557
66MST40.34971258
67AURKA0.33937658
68CDK11A0.33634712
69FRK0.33446495
70TBK10.33397967
71TGFBR20.33338525
72SCYL20.33250793
73PRKCB0.31860530
74FGFR30.30431278
75AURKB0.30326966
76CDK150.29141483
77CDK180.28832813
78INSRR0.26851033
79MKNK20.26686307
80OBSCN0.26628037
81CAMK2A0.25108494
82CSNK2A10.21681322
83TIE10.19957560
84PRKACA0.19345794
85NEK60.19147006
86EIF2AK20.18294922
87CDK50.17609598
88CAMKK10.17153323
89NEK20.16606072
90SRC0.15525757
91PRKAA10.15444529
92CSNK1G30.15436729
93EGFR0.15253156
94TAOK10.15087713
95CSNK1A10.14674923
96VRK20.14449416
97IKBKE0.14372182
98MAP3K10.14069927
99AKT10.13739276
100CDK140.12915880

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.28571259
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046234.53036993
3T cell receptor signaling pathway_Homo sapiens_hsa046603.82553416
4Protein export_Homo sapiens_hsa030603.21800099
5Hematopoietic cell lineage_Homo sapiens_hsa046403.11094153
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.01613163
7Salmonella infection_Homo sapiens_hsa051322.88288510
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.67763900
9Graft-versus-host disease_Homo sapiens_hsa053322.65556783
10Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.55932729
11RNA polymerase_Homo sapiens_hsa030202.47226478
12Antigen processing and presentation_Homo sapiens_hsa046122.40307759
13Chemokine signaling pathway_Homo sapiens_hsa040622.39852631
14Allograft rejection_Homo sapiens_hsa053302.36023282
15Autoimmune thyroid disease_Homo sapiens_hsa053202.23830422
16Rheumatoid arthritis_Homo sapiens_hsa053232.19905789
17Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10113963
18Measles_Homo sapiens_hsa051622.01741327
19Type I diabetes mellitus_Homo sapiens_hsa049401.65510234
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64143922
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39196975
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36963690
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33509629
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24378542
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.16171026
26Caffeine metabolism_Homo sapiens_hsa002321.13546352
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11154214
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.06941243
29Prion diseases_Homo sapiens_hsa050200.94547375
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85770300
31Epstein-Barr virus infection_Homo sapiens_hsa051690.85140124
32Malaria_Homo sapiens_hsa051440.85067988
33Viral myocarditis_Homo sapiens_hsa054160.83072681
34B cell receptor signaling pathway_Homo sapiens_hsa046620.81866946
35Asthma_Homo sapiens_hsa053100.80478787
36Proteasome_Homo sapiens_hsa030500.78912759
37TNF signaling pathway_Homo sapiens_hsa046680.74833957
38Shigellosis_Homo sapiens_hsa051310.73751044
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73555384
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72686520
41Apoptosis_Homo sapiens_hsa042100.63853668
42NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63267991
43Oxidative phosphorylation_Homo sapiens_hsa001900.62729165
44Parkinsons disease_Homo sapiens_hsa050120.61723246
45HTLV-I infection_Homo sapiens_hsa051660.61098275
46Endocytosis_Homo sapiens_hsa041440.60775967
47Pyrimidine metabolism_Homo sapiens_hsa002400.58785002
48Herpes simplex infection_Homo sapiens_hsa051680.56258856
49Nitrogen metabolism_Homo sapiens_hsa009100.53973666
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52838063
51Osteoclast differentiation_Homo sapiens_hsa043800.51506469
52Pancreatic secretion_Homo sapiens_hsa049720.51172854
53Sulfur relay system_Homo sapiens_hsa041220.51068967
54Phototransduction_Homo sapiens_hsa047440.48084923
55Influenza A_Homo sapiens_hsa051640.36930305
56Salivary secretion_Homo sapiens_hsa049700.35938082
57Purine metabolism_Homo sapiens_hsa002300.35860244
58Mineral absorption_Homo sapiens_hsa049780.35297657
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35063544
60Leishmaniasis_Homo sapiens_hsa051400.31086992
61Platelet activation_Homo sapiens_hsa046110.30817176
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.30544112
63Legionellosis_Homo sapiens_hsa051340.30520801
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29704029
65Alzheimers disease_Homo sapiens_hsa050100.28594015
66Calcium signaling pathway_Homo sapiens_hsa040200.27730244
67Staphylococcus aureus infection_Homo sapiens_hsa051500.27618317
68Sulfur metabolism_Homo sapiens_hsa009200.27602660
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26106030
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.25612310
71Homologous recombination_Homo sapiens_hsa034400.25033836
72Systemic lupus erythematosus_Homo sapiens_hsa053220.24034821
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23524251
74cAMP signaling pathway_Homo sapiens_hsa040240.23163967
75Cardiac muscle contraction_Homo sapiens_hsa042600.21824512
76Non-small cell lung cancer_Homo sapiens_hsa052230.21539301
77Mismatch repair_Homo sapiens_hsa034300.18868874
78Huntingtons disease_Homo sapiens_hsa050160.17752656
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16183869
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15084276
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.14750877
82Tuberculosis_Homo sapiens_hsa051520.14497044
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14446282
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12897052
85African trypanosomiasis_Homo sapiens_hsa051430.12774736
86Complement and coagulation cascades_Homo sapiens_hsa046100.12504837
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.12314857
88Phagosome_Homo sapiens_hsa041450.12249028
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12188671
90Ether lipid metabolism_Homo sapiens_hsa005650.11833426
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11810196
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.11219432
93Regulation of autophagy_Homo sapiens_hsa041400.11004711
94Bladder cancer_Homo sapiens_hsa052190.10648291
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.10112786
96Pancreatic cancer_Homo sapiens_hsa052120.09658330
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09270400
98Glycerolipid metabolism_Homo sapiens_hsa005610.09220957
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.08657075
100Cholinergic synapse_Homo sapiens_hsa047250.07945013

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