TRBV3-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.09497404
2positive regulation of gamma-delta T cell activation (GO:0046645)7.59823940
3negative thymic T cell selection (GO:0045060)7.34902014
4tolerance induction (GO:0002507)7.01471078
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.88823426
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.44239474
7positive T cell selection (GO:0043368)6.07808106
8regulation of gamma-delta T cell differentiation (GO:0045586)6.05583309
9T cell selection (GO:0045058)5.93444077
10thymic T cell selection (GO:0045061)5.93390519
11response to interleukin-15 (GO:0070672)5.80766412
12positive regulation of granulocyte differentiation (GO:0030854)5.51070001
13regulation of gamma-delta T cell activation (GO:0046643)5.46310101
14Peyers patch development (GO:0048541)5.41433810
15mucosal-associated lymphoid tissue development (GO:0048537)5.41433810
16leukocyte aggregation (GO:0070486)5.34372298
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.34274079
18cellular response to interleukin-15 (GO:0071350)5.29914172
19positive thymic T cell selection (GO:0045059)5.29233771
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.28160371
21regulation of interleukin-2 biosynthetic process (GO:0045076)5.26868402
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.23946258
23negative regulation of cell killing (GO:0031342)5.23946258
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04660521
25negative regulation of myotube differentiation (GO:0010832)4.88206149
26antigen processing and presentation of endogenous antigen (GO:0019883)4.79236635
27regulation of T cell tolerance induction (GO:0002664)4.72985792
28T cell migration (GO:0072678)4.49143281
29positive regulation of tolerance induction (GO:0002645)4.29509201
30regulation of regulatory T cell differentiation (GO:0045589)4.18008365
31positive regulation of B cell differentiation (GO:0045579)4.16574820
32regulation of isotype switching to IgG isotypes (GO:0048302)4.10999024
33regulation of B cell receptor signaling pathway (GO:0050855)4.10659741
34heart trabecula morphogenesis (GO:0061384)4.09829094
35negative regulation of erythrocyte differentiation (GO:0045647)4.09445970
36positive regulation of interleukin-2 production (GO:0032743)4.05293214
37activated T cell proliferation (GO:0050798)4.01425119
38regulation of natural killer cell mediated immunity (GO:0002715)3.99971443
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.99971443
40regulation of alpha-beta T cell proliferation (GO:0046640)3.99643086
41positive regulation of natural killer cell differentiation (GO:0032825)3.97437727
42trabecula morphogenesis (GO:0061383)3.95124292
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.92986144
44regulation of tolerance induction (GO:0002643)3.92779953
45ventricular trabecula myocardium morphogenesis (GO:0003222)3.90367738
46T cell receptor signaling pathway (GO:0050852)3.88243644
47positive regulation of interleukin-4 production (GO:0032753)3.82005861
48alpha-beta T cell differentiation (GO:0046632)3.79336748
49positive regulation of natural killer cell mediated immunity (GO:0002717)3.67550747
50antigen receptor-mediated signaling pathway (GO:0050851)3.63550464
51negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.63466233
52negative regulation of T cell mediated immunity (GO:0002710)3.61028428
53regulation of interleukin-4 production (GO:0032673)3.57923747
54regulation of granulocyte differentiation (GO:0030852)3.57614001
55V(D)J recombination (GO:0033151)3.55275162
56positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.55150731
57T cell homeostasis (GO:0043029)3.55069922
58alpha-beta T cell activation (GO:0046631)3.47567470
59natural killer cell differentiation (GO:0001779)3.47401132
60signal complex assembly (GO:0007172)3.44893290
61regulation of B cell differentiation (GO:0045577)3.43877249
62positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.42065726
63apoptotic process involved in morphogenesis (GO:0060561)3.39793058
64T cell differentiation (GO:0030217)3.39184467
65positive regulation of alpha-beta T cell activation (GO:0046635)3.34727361
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.33913633
67positive regulation of DNA-templated transcription, initiation (GO:2000144)3.30348332
68regulation of interleukin-2 production (GO:0032663)3.29838960
69positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.27033619
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.26305069
71regulation of alpha-beta T cell activation (GO:0046634)3.23266099
72regulation of defense response to virus by virus (GO:0050690)3.21710339
73positive regulation of T cell differentiation in thymus (GO:0033089)3.20605012
74mast cell activation (GO:0045576)3.19990116
75positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.18222564
76positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.17865638
77positive regulation of calcium-mediated signaling (GO:0050850)3.15358805
78B cell receptor signaling pathway (GO:0050853)3.11817375
79positive regulation of alpha-beta T cell differentiation (GO:0046638)3.11158478
80regulation of leukocyte mediated cytotoxicity (GO:0001910)3.09029335
81interferon-gamma production (GO:0032609)3.08533776
82cellular response to interleukin-4 (GO:0071353)3.07594437
83regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.07325253
84regulation of T cell receptor signaling pathway (GO:0050856)3.03513837
85T cell costimulation (GO:0031295)3.01177398
86positive regulation of T cell differentiation (GO:0045582)3.00134336
87CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.99067337
88regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.97485097
89lymphocyte costimulation (GO:0031294)2.97345436
90response to interleukin-4 (GO:0070670)2.97014552
91positive regulation of cell killing (GO:0031343)2.94448757
92regulation of alpha-beta T cell differentiation (GO:0046637)2.94105320
93T-helper cell differentiation (GO:0042093)2.87223053
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.87223053
95cardiac ventricle formation (GO:0003211)2.83973997
96regulation of cell killing (GO:0031341)2.83832772
97T cell activation (GO:0042110)2.83737549
98regulation of natural killer cell differentiation (GO:0032823)2.82198372
99negative regulation of leukocyte mediated immunity (GO:0002704)2.80381746
100positive regulation of isotype switching (GO:0045830)2.79870312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.71736047
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.35952750
3RUNX_20019798_ChIP-Seq_JUKART_Human3.97166639
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.84354871
5MYB_26560356_Chip-Seq_TH2_Human3.60495232
6MYC_22102868_ChIP-Seq_BL_Human3.56572309
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29824008
8UTX_26944678_Chip-Seq_JUKART_Human3.15013019
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07749546
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96981450
11MAF_26560356_Chip-Seq_TH1_Human2.96644865
12MYB_26560356_Chip-Seq_TH1_Human2.92599625
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.70444209
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68186222
15VDR_21846776_ChIP-Seq_THP-1_Human2.66131949
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59185057
17MAF_26560356_Chip-Seq_TH2_Human2.54627106
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54023148
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.49670780
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44754912
21GATA3_27048872_Chip-Seq_THYMUS_Human2.34556463
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.33385407
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.27184549
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.23150115
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21283207
26CIITA_25753668_ChIP-Seq_RAJI_Human2.17889250
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15783562
28SPI1_23547873_ChIP-Seq_NB4_Human2.15529473
29SCL_19346495_ChIP-Seq_HPC-7_Human2.12458933
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08672935
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08557684
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03475581
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.02093596
34KDM2B_26808549_Chip-Seq_DND41_Human2.01434500
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99861492
36TCF7_22412390_ChIP-Seq_EML_Mouse1.98421293
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97925065
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94438240
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.94302634
40VDR_24763502_ChIP-Seq_THP-1_Human1.91332116
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84069226
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.73100542
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.71992093
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65703034
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62636197
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62443245
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62236879
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.58604007
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57934707
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56168150
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56051371
52SPI1_23127762_ChIP-Seq_K562_Human1.48312096
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46632919
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43471358
55GATA3_26560356_Chip-Seq_TH2_Human1.42750027
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41372673
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36659780
58E2F7_22180533_ChIP-Seq_HELA_Human1.33005578
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30143706
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29629492
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29522067
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.28564343
63FOXP3_21729870_ChIP-Seq_TREG_Human1.21406706
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21134520
65VDR_23849224_ChIP-Seq_CD4+_Human1.11876164
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11815621
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09328415
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08900895
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06566507
70PU_27001747_Chip-Seq_BMDM_Mouse1.05552448
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05497456
72GATA1_22025678_ChIP-Seq_K562_Human1.04877833
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04775382
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04269478
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03679424
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02568311
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01913738
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01009461
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97965223
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97426749
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96989326
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.95340600
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92036671
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.91433663
85NCOR1_26117541_ChIP-Seq_K562_Human0.90959422
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90840215
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90420886
88GATA1_19941826_ChIP-Seq_K562_Human0.89801648
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89294780
90BCL6_27268052_Chip-Seq_Bcells_Human0.88951116
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88930362
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87865226
93CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84246890
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83630839
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82860090
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82086991
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80618142
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79617265
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78885788
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78587492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.25843292
2MP0005671_abnormal_response_to3.85206783
3MP0009333_abnormal_splenocyte_physiolog3.52802078
4MP0003436_decreased_susceptibility_to3.27145828
5MP0000703_abnormal_thymus_morphology3.07685934
6MP0001800_abnormal_humoral_immune2.97974131
7MP0005000_abnormal_immune_tolerance2.96406433
8MP0001790_abnormal_immune_system2.95281290
9MP0005387_immune_system_phenotype2.95281290
10MP0001835_abnormal_antigen_presentation2.92273005
11MP0000685_abnormal_immune_system2.89968301
12MP0003724_increased_susceptibility_to2.87406837
13MP0003300_gastrointestinal_ulcer2.71189622
14MP0002398_abnormal_bone_marrow2.60780071
15MP0002723_abnormal_immune_serum2.57662397
16MP0001873_stomach_inflammation2.57555434
17MP0002420_abnormal_adaptive_immunity2.57131199
18MP0001819_abnormal_immune_cell2.52883384
19MP0004947_skin_inflammation2.48085220
20MP0002405_respiratory_system_inflammati2.45046545
21MP0004381_abnormal_hair_follicle2.41714642
22MP0002148_abnormal_hypersensitivity_rea2.30002158
23MP0005025_abnormal_response_to2.25626550
24MP0000716_abnormal_immune_system2.23854173
25MP0002396_abnormal_hematopoietic_system2.23528566
26MP0003866_abnormal_defecation2.23202371
27MP0002722_abnormal_immune_system2.22666253
28MP0002452_abnormal_antigen_presenting2.17166596
29MP0010155_abnormal_intestine_physiology2.09425201
30MP0000689_abnormal_spleen_morphology2.05652484
31MP0003279_aneurysm2.02866328
32MP0009785_altered_susceptibility_to1.98945641
33MP0002009_preneoplasia1.93967348
34MP0002419_abnormal_innate_immunity1.91316396
35MP0002429_abnormal_blood_cell1.83996633
36MP0003303_peritoneal_inflammation1.76957867
37MP0003787_abnormal_imprinting1.75902485
38MP0002234_abnormal_pharynx_morphology1.71172810
39MP0005075_abnormal_melanosome_morpholog1.63256033
40MP0002163_abnormal_gland_morphology1.59689639
41MP0000465_gastrointestinal_hemorrhage1.58008371
42MP0006082_CNS_inflammation1.56212829
43MP0002166_altered_tumor_susceptibility1.52937140
44MP0005464_abnormal_platelet_physiology1.52163784
45MP0000490_abnormal_crypts_of1.49367805
46MP0005310_abnormal_salivary_gland1.47986998
47MP0001845_abnormal_inflammatory_respons1.44817896
48MP0009278_abnormal_bone_marrow1.42834724
49MP0004808_abnormal_hematopoietic_stem1.42439263
50MP0001851_eye_inflammation1.32752198
51MP0002933_joint_inflammation1.14642407
52MP0001533_abnormal_skeleton_physiology1.13936044
53MP0001348_abnormal_lacrimal_gland1.06805819
54MP0002277_abnormal_respiratory_mucosa1.00493889
55MP0001853_heart_inflammation0.96596920
56MP0005451_abnormal_body_composition0.95060596
57MP0008469_abnormal_protein_level0.94738987
58MP0002006_tumorigenesis0.92808998
59MP0004019_abnormal_vitamin_homeostasis0.92727667
60MP0002019_abnormal_tumor_incidence0.85902575
61MP0001663_abnormal_digestive_system0.85280924
62MP0008057_abnormal_DNA_replication0.85241855
63MP0004185_abnormal_adipocyte_glucose0.85086926
64MP0000858_altered_metastatic_potential0.81201768
65MP0009764_decreased_sensitivity_to0.79457451
66MP0008260_abnormal_autophagy0.79265227
67MP0005379_endocrine/exocrine_gland_phen0.74130271
68MP0003077_abnormal_cell_cycle0.72615027
69MP0000313_abnormal_cell_death0.70531144
70MP0008961_abnormal_basal_metabolism0.69273132
71MP0004036_abnormal_muscle_relaxation0.69188969
72MP0002877_abnormal_melanocyte_morpholog0.66462142
73MP0003183_abnormal_peptide_metabolism0.65886602
74MP0002132_abnormal_respiratory_system0.65501049
75MP0009763_increased_sensitivity_to0.65083870
76MP0003045_fibrosis0.61328271
77MP0003959_abnormal_lean_body0.61001018
78MP0003693_abnormal_embryo_hatching0.60819413
79MP0003828_pulmonary_edema0.60469669
80MP0004130_abnormal_muscle_cell0.60426212
81MP0001545_abnormal_hematopoietic_system0.57715730
82MP0005397_hematopoietic_system_phenotyp0.57715730
83MP0001666_abnormal_nutrient_absorption0.57521223
84MP0001765_abnormal_ion_homeostasis0.57193822
85MP0002693_abnormal_pancreas_physiology0.56766332
86MP0005666_abnormal_adipose_tissue0.56542367
87MP0003111_abnormal_nucleus_morphology0.54784812
88MP0003448_altered_tumor_morphology0.53504298
89MP0008877_abnormal_DNA_methylation0.51929113
90MP0000733_abnormal_muscle_development0.51785300
91MP0003172_abnormal_lysosome_physiology0.50684992
92MP0003221_abnormal_cardiomyocyte_apopto0.47402946
93MP0002138_abnormal_hepatobiliary_system0.47332428
94MP0005535_abnormal_body_temperature0.46724152
95MP0004264_abnormal_extraembryonic_tissu0.46629225
96MP0000015_abnormal_ear_pigmentation0.46219520
97MP0003943_abnormal_hepatobiliary_system0.45674615
98MP0001919_abnormal_reproductive_system0.45422429
99MP0005330_cardiomyopathy0.45265326
100MP0000350_abnormal_cell_proliferation0.44624591

Predicted human phenotypes

RankGene SetZ-score
1Subaortic stenosis (HP:0001682)6.81889105
2Abnormality of the left ventricular outflow tract (HP:0011103)6.81889105
3Severe combined immunodeficiency (HP:0004430)6.12057659
4Eczematoid dermatitis (HP:0000976)5.71389340
5Autoimmune hemolytic anemia (HP:0001890)5.31551215
6T lymphocytopenia (HP:0005403)5.25472721
7Stomatitis (HP:0010280)5.16611338
8Combined immunodeficiency (HP:0005387)5.10400590
9Abnormality of T cell number (HP:0011839)4.89663702
10Increased IgM level (HP:0003496)4.81560970
11Elevated erythrocyte sedimentation rate (HP:0003565)4.64870086
12Recurrent fungal infections (HP:0002841)4.33234704
13Double outlet right ventricle (HP:0001719)4.29866490
14Congenital malformation of the right heart (HP:0011723)4.29866490
15Increased IgE level (HP:0003212)4.10339956
16Abnormality of T cells (HP:0002843)4.06422783
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.82701387
18IgG deficiency (HP:0004315)3.71101049
19Granulocytopenia (HP:0001913)3.68937180
20Panhypogammaglobulinemia (HP:0003139)3.66532740
21Recurrent cutaneous fungal infections (HP:0011370)3.62834330
22Chronic mucocutaneous candidiasis (HP:0002728)3.62834330
23Myositis (HP:0100614)3.52622545
24Encephalitis (HP:0002383)3.49984187
25Lymphopenia (HP:0001888)3.44514339
26Abnormality of eosinophils (HP:0001879)3.40899649
27Abnormality of chromosome segregation (HP:0002916)3.28933022
28Eosinophilia (HP:0001880)3.28661290
29Abnormality of cells of the lymphoid lineage (HP:0012140)3.27990632
30B lymphocytopenia (HP:0010976)3.26426320
31Thyroiditis (HP:0100646)3.21607331
32Recurrent abscess formation (HP:0002722)3.19688676
33Recurrent viral infections (HP:0004429)3.19119046
34Leukocytosis (HP:0001974)3.17474413
35Meningitis (HP:0001287)3.14925655
36Abnormality of B cell number (HP:0010975)3.13468435
37Autoimmune thrombocytopenia (HP:0001973)3.07724114
38Abnormality of T cell physiology (HP:0011840)3.02017299
39Hypergammaglobulinemia (HP:0010702)2.99944514
40Truncus arteriosus (HP:0001660)2.97866450
41Hypochromic anemia (HP:0001931)2.91583247
42Gastrointestinal infarctions (HP:0005244)2.91075084
43Orchitis (HP:0100796)2.89921625
44Acute hepatic failure (HP:0006554)2.86850550
45Recurrent bacterial skin infections (HP:0005406)2.84596890
46Pustule (HP:0200039)2.84441368
47Spontaneous hematomas (HP:0007420)2.84377849
48Abnormality of macrophages (HP:0004311)2.84235142
49Joint swelling (HP:0001386)2.78228511
50Hypoplasia of the thymus (HP:0000778)2.76844169
51Retrobulbar optic neuritis (HP:0100654)2.73997530
52Optic neuritis (HP:0100653)2.73997530
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.73451977
54Chronic diarrhea (HP:0002028)2.72773573
55Hypochromic microcytic anemia (HP:0004840)2.71396781
56Chronic obstructive pulmonary disease (HP:0006510)2.66272168
57Obstructive lung disease (HP:0006536)2.66272168
58Mediastinal lymphadenopathy (HP:0100721)2.65832573
59IgM deficiency (HP:0002850)2.65815050
60Lymphoma (HP:0002665)2.63227345
61Recurrent skin infections (HP:0001581)2.62759691
62Prolonged bleeding time (HP:0003010)2.62538303
63Recurrent bronchitis (HP:0002837)2.60780536
64Vasculitis (HP:0002633)2.58904897
65Aplasia/Hypoplasia of the thymus (HP:0010515)2.54877001
66Chest pain (HP:0100749)2.46602156
67Hypoplastic left heart (HP:0004383)2.45965579
68Abnormality of the fingertips (HP:0001211)2.45479965
69Impaired proprioception (HP:0010831)2.41165909
70Papilledema (HP:0001085)2.38051181
71Cholecystitis (HP:0001082)2.30444900
72Abnormal gallbladder physiology (HP:0012438)2.30444900
73Recurrent gram-negative bacterial infections (HP:0005420)2.25410349
74Keratoconjunctivitis sicca (HP:0001097)2.20837269
75Gastrointestinal inflammation (HP:0004386)2.17529559
76Slow saccadic eye movements (HP:0000514)2.13831999
77Maternal diabetes (HP:0009800)2.13819339
78Pulmonary artery stenosis (HP:0004415)2.13790564
79Inflammation of the large intestine (HP:0002037)2.13655633
80Agammaglobulinemia (HP:0004432)2.13541547
81Epistaxis (HP:0000421)2.11553581
82Microcytic anemia (HP:0001935)2.11465371
83Verrucae (HP:0200043)2.09142392
84Papilloma (HP:0012740)2.09142392
85Hemoptysis (HP:0002105)2.03937312
86Keratoconjunctivitis (HP:0001096)2.03153095
87Pulmonary infiltrates (HP:0002113)2.02037160
88Episodic fever (HP:0001954)2.00845813
89Micronodular cirrhosis (HP:0001413)1.97720168
90Dyschromatopsia (HP:0007641)1.97440812
91Acute lymphatic leukemia (HP:0006721)1.97017072
92Urticaria (HP:0001025)1.93490882
93Sepsis (HP:0100806)1.93422890
94Hypoplastic heart (HP:0001961)1.93288978
95Abnormality of the thymus (HP:0000777)1.92795010
96Segmental peripheral demyelination/remyelination (HP:0003481)1.89635594
97Fatigue (HP:0012378)1.81401921
98Cellulitis (HP:0100658)1.81149228
99Basal cell carcinoma (HP:0002671)1.80087434
100Respiratory difficulties (HP:0002880)1.78792584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.86699942
2MAP4K14.67534489
3RIPK43.36377364
4PRPF4B2.86660338
5ITK2.59703318
6NLK2.56109388
7TYK22.49601185
8ZAP702.44489451
9FES2.21194699
10SIK32.13094186
11BTK2.12987558
12GRK62.02932126
13FGFR41.82596794
14MAP3K101.80736452
15JAK31.79372206
16SMG11.73690520
17SYK1.70475359
18CSK1.65697954
19LCK1.64226482
20PASK1.62517094
21HCK1.61758181
22TNK21.60046517
23HIPK21.58591174
24TAOK31.55638903
25CDK121.51993340
26MAPK111.49487099
27SIK21.48085021
28IRAK41.47326318
29TRIB31.42130110
30CAMKK11.41272328
31PKN21.35354888
32TEC1.32809642
33TESK21.26195524
34MARK31.20943523
35CDK61.20851621
36MAP2K31.17147165
37FGFR31.17137552
38LRRK21.16904812
39LYN1.16240927
40JAK11.15850522
41PTK61.15372511
42IKBKE1.14778498
43TYRO31.14209972
44JAK21.13036721
45MAP3K141.09390015
46ERN11.08454353
47CLK11.07606514
48STK101.03499720
49MAP3K130.98960250
50SCYL20.94238227
51CDK40.93350316
52PRKCQ0.93116348
53CDK190.92250630
54EPHB10.92074453
55BLK0.87936829
56TAOK20.86462497
57SIK10.84626650
58BRD40.83049518
59KDR0.80933160
60FGFR20.78551951
61TAF10.75430774
62MARK20.73608752
63CAMKK20.72333877
64MAP3K10.68958300
65YES10.68417552
66MAPK120.65063495
67TAOK10.64859285
68TBK10.60427550
69MAP3K110.59631906
70UHMK10.58363075
71PIM10.56514943
72PDK10.55556272
73IRAK10.55159239
74RET0.53146753
75STK40.52526703
76BRAF0.52228384
77KSR20.51816816
78NTRK20.51462159
79MAPK40.49541203
80MAP3K70.48843676
81PRKCH0.48235433
82FYN0.47649292
83MELK0.46323729
84ICK0.43913806
85TESK10.41965967
86CSF1R0.41672378
87IKBKB0.41135391
88BUB10.40997303
89PDGFRB0.40091624
90CDK90.39239318
91MAP3K30.39171796
92MAPK70.36988101
93BMPR20.36349530
94MAPKAPK20.33856079
95MAPK30.33126697
96VRK20.30839568
97RPS6KC10.28165882
98RPS6KL10.28165882
99RAF10.27416728
100FGR0.26087024

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.40092149
2T cell receptor signaling pathway_Homo sapiens_hsa046604.00471726
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.20534398
4Measles_Homo sapiens_hsa051622.90276063
5Graft-versus-host disease_Homo sapiens_hsa053322.80177812
6Acute myeloid leukemia_Homo sapiens_hsa052212.55235677
7Allograft rejection_Homo sapiens_hsa053302.20234235
8B cell receptor signaling pathway_Homo sapiens_hsa046622.19975213
9Autoimmune thyroid disease_Homo sapiens_hsa053202.16037752
10Hematopoietic cell lineage_Homo sapiens_hsa046402.14206041
11Osteoclast differentiation_Homo sapiens_hsa043802.00383503
12Antigen processing and presentation_Homo sapiens_hsa046121.98470955
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.89656327
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84309653
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79017664
16Non-small cell lung cancer_Homo sapiens_hsa052231.71116392
17Herpes simplex infection_Homo sapiens_hsa051681.70814810
18Chronic myeloid leukemia_Homo sapiens_hsa052201.66337688
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.59959325
20Leishmaniasis_Homo sapiens_hsa051401.56043804
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52944024
22Chemokine signaling pathway_Homo sapiens_hsa040621.50862662
23Type I diabetes mellitus_Homo sapiens_hsa049401.50579511
24Hepatitis B_Homo sapiens_hsa051611.50403333
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50117838
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38915751
27Pancreatic cancer_Homo sapiens_hsa052121.37994740
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33308323
29Viral myocarditis_Homo sapiens_hsa054161.32590691
30Thyroid cancer_Homo sapiens_hsa052161.32454703
31HTLV-I infection_Homo sapiens_hsa051661.29680994
32Colorectal cancer_Homo sapiens_hsa052101.24951534
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.18495861
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14743746
35Malaria_Homo sapiens_hsa051441.14619666
36Viral carcinogenesis_Homo sapiens_hsa052031.14361074
37Epstein-Barr virus infection_Homo sapiens_hsa051691.13721073
38VEGF signaling pathway_Homo sapiens_hsa043701.11967751
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.11561578
40Endometrial cancer_Homo sapiens_hsa052131.10795398
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05476022
42TNF signaling pathway_Homo sapiens_hsa046681.02602818
43Influenza A_Homo sapiens_hsa051641.01627481
44African trypanosomiasis_Homo sapiens_hsa051431.00711394
45Tuberculosis_Homo sapiens_hsa051520.96896752
46Ribosome_Homo sapiens_hsa030100.93566996
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88809479
48Platelet activation_Homo sapiens_hsa046110.86393049
49Toxoplasmosis_Homo sapiens_hsa051450.85527124
50Shigellosis_Homo sapiens_hsa051310.85227271
51Renal cell carcinoma_Homo sapiens_hsa052110.84761195
52Prolactin signaling pathway_Homo sapiens_hsa049170.84754969
53Prostate cancer_Homo sapiens_hsa052150.83407960
54Spliceosome_Homo sapiens_hsa030400.81529596
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78792365
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78762909
57Apoptosis_Homo sapiens_hsa042100.77750488
58HIF-1 signaling pathway_Homo sapiens_hsa040660.77495099
59Staphylococcus aureus infection_Homo sapiens_hsa051500.77234790
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76387972
61ErbB signaling pathway_Homo sapiens_hsa040120.71269555
62Hepatitis C_Homo sapiens_hsa051600.71042297
63FoxO signaling pathway_Homo sapiens_hsa040680.69480151
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69181653
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68583037
66Inositol phosphate metabolism_Homo sapiens_hsa005620.64854509
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.64333820
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.62095213
69mRNA surveillance pathway_Homo sapiens_hsa030150.61000191
70Legionellosis_Homo sapiens_hsa051340.59514557
71Glioma_Homo sapiens_hsa052140.58163165
72Endocytosis_Homo sapiens_hsa041440.57812591
73Regulation of autophagy_Homo sapiens_hsa041400.55178789
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50481607
75MAPK signaling pathway_Homo sapiens_hsa040100.49724134
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49012753
77Cell cycle_Homo sapiens_hsa041100.48922276
78Choline metabolism in cancer_Homo sapiens_hsa052310.48395705
79Pentose phosphate pathway_Homo sapiens_hsa000300.45514308
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.44049763
81Notch signaling pathway_Homo sapiens_hsa043300.42929363
82mTOR signaling pathway_Homo sapiens_hsa041500.42696381
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40941386
84Insulin resistance_Homo sapiens_hsa049310.39834402
85Base excision repair_Homo sapiens_hsa034100.36231000
86DNA replication_Homo sapiens_hsa030300.36193034
87Rheumatoid arthritis_Homo sapiens_hsa053230.35985930
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35825561
89Long-term potentiation_Homo sapiens_hsa047200.34460870
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33771127
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33595518
92Dorso-ventral axis formation_Homo sapiens_hsa043200.31606408
93Salmonella infection_Homo sapiens_hsa051320.31491311
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30836162
95Ras signaling pathway_Homo sapiens_hsa040140.30159658
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.29956101
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28984267
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27916847
99Insulin signaling pathway_Homo sapiens_hsa049100.25810040
100Small cell lung cancer_Homo sapiens_hsa052220.23991211

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