TRBV27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T cell migration (GO:0072678)8.33415953
2cytidine deamination (GO:0009972)5.81416995
3cytidine metabolic process (GO:0046087)5.81416995
4cytidine catabolic process (GO:0006216)5.81416995
5positive regulation of gamma-delta T cell activation (GO:0046645)5.75086286
6cellular response to interleukin-15 (GO:0071350)5.47479400
7DNA deamination (GO:0045006)5.34056756
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.29178070
9response to interleukin-15 (GO:0070672)5.20064620
10negative regulation of type 2 immune response (GO:0002829)5.19186350
11positive regulation of T cell chemotaxis (GO:0010820)5.06603893
12regulation of T cell chemotaxis (GO:0010819)5.06603893
13lymphocyte chemotaxis (GO:0048247)5.02896333
14regulation of B cell differentiation (GO:0045577)5.02878716
15positive thymic T cell selection (GO:0045059)4.91321148
16regulation of B cell receptor signaling pathway (GO:0050855)4.87325002
17positive regulation of B cell differentiation (GO:0045579)4.84485843
18lymphocyte migration (GO:0072676)4.81210483
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.78864390
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.76132777
21positive regulation of alpha-beta T cell proliferation (GO:0046641)4.71157897
22regulation of alpha-beta T cell proliferation (GO:0046640)4.56269703
23antigen processing and presentation of endogenous antigen (GO:0019883)4.53785904
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51392963
25regulation of gamma-delta T cell differentiation (GO:0045586)4.51327512
26negative regulation of T cell apoptotic process (GO:0070233)4.48882188
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.47450257
28positive regulation of T-helper 1 type immune response (GO:0002827)4.39796802
29negative thymic T cell selection (GO:0045060)4.38050080
30positive regulation of granulocyte differentiation (GO:0030854)4.36913347
31positive T cell selection (GO:0043368)4.33328019
32thymic T cell selection (GO:0045061)4.29397458
33negative T cell selection (GO:0043383)4.29389406
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28312041
35positive regulation of T cell migration (GO:2000406)4.22613239
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21996542
37regulation of gamma-delta T cell activation (GO:0046643)4.17786071
38positive regulation of monocyte chemotaxis (GO:0090026)4.11854664
39negative regulation of leukocyte mediated immunity (GO:0002704)3.95963866
40regulation of T-helper 1 type immune response (GO:0002825)3.88653825
41regulation of cellular extravasation (GO:0002691)3.74651100
42T cell selection (GO:0045058)3.73878095
43immunoglobulin mediated immune response (GO:0016064)3.72504563
44regulation of T-helper 1 cell differentiation (GO:0045625)3.71128252
45positive regulation of lymphocyte migration (GO:2000403)3.70100137
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.68385124
47regulation of T cell migration (GO:2000404)3.67632834
48cytolysis (GO:0019835)3.66989400
49response to interferon-beta (GO:0035456)3.65044533
50regulation of T cell tolerance induction (GO:0002664)3.63672237
51positive regulation of tolerance induction (GO:0002645)3.59393783
52positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.57759195
53production of molecular mediator involved in inflammatory response (GO:0002532)3.57258612
54negative regulation of viral genome replication (GO:0045071)3.56214376
55dendritic cell chemotaxis (GO:0002407)3.55826262
56positive regulation of interleukin-8 secretion (GO:2000484)3.50121009
57negative regulation of lymphocyte apoptotic process (GO:0070229)3.47971757
58positive regulation of defense response to virus by host (GO:0002230)3.47433182
59T cell receptor signaling pathway (GO:0050852)3.44567811
60intestinal cholesterol absorption (GO:0030299)3.42152601
61regulation of lymphocyte chemotaxis (GO:1901623)3.41769994
62positive regulation of interleukin-2 production (GO:0032743)3.41140749
63activated T cell proliferation (GO:0050798)3.40460811
64mast cell activation (GO:0045576)3.39281626
65T cell costimulation (GO:0031295)3.39262386
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35171410
67lymphocyte costimulation (GO:0031294)3.34709443
68respiratory burst (GO:0045730)3.34163554
69mast cell degranulation (GO:0043303)3.32912096
70mast cell activation involved in immune response (GO:0002279)3.32912096
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.32734918
72regulation of tolerance induction (GO:0002643)3.29519517
73regulation of interleukin-2 biosynthetic process (GO:0045076)3.26626374
74antigen receptor-mediated signaling pathway (GO:0050851)3.26292111
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23395758
76regulation of T cell mediated cytotoxicity (GO:0001914)3.22714905
77positive regulation of alpha-beta T cell activation (GO:0046635)3.21775515
78response to type I interferon (GO:0034340)3.20848807
79regulation of alpha-beta T cell activation (GO:0046634)3.20241629
80Peyers patch development (GO:0048541)3.20195806
81mucosal-associated lymphoid tissue development (GO:0048537)3.20195806
82B cell receptor signaling pathway (GO:0050853)3.19157601
83cellular response to type I interferon (GO:0071357)3.19117139
84type I interferon signaling pathway (GO:0060337)3.19117139
85B cell mediated immunity (GO:0019724)3.14524628
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12336570
87regulation of granulocyte differentiation (GO:0030852)3.09937829
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09806835
89negative regulation of cell killing (GO:0031342)3.09806835
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09734876
91negative regulation of T-helper cell differentiation (GO:0045623)3.05321490
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05321490
93regulation of type 2 immune response (GO:0002828)3.04163130
94very-low-density lipoprotein particle assembly (GO:0034379)3.03513873
95T-helper cell differentiation (GO:0042093)3.00259171
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.00259171
97regulation of lymphocyte migration (GO:2000401)2.98021235
98chemokine-mediated signaling pathway (GO:0070098)2.97235594
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96498249
100negative regulation of cytokine production involved in immune response (GO:0002719)2.94960187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.15228595
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.88083708
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.15911882
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.02182099
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49707056
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.61731529
7MYB_26560356_Chip-Seq_TH2_Human3.60435712
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.45139174
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.37832517
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18057479
11RUNX_20019798_ChIP-Seq_JUKART_Human2.98663443
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89811525
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76425723
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64540772
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60415560
16UTX_26944678_Chip-Seq_JUKART_Human2.54937177
17MAF_26560356_Chip-Seq_TH1_Human2.46492906
18GATA3_27048872_Chip-Seq_THYMUS_Human2.40989468
19MYB_26560356_Chip-Seq_TH1_Human2.38983544
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35180763
21MAF_26560356_Chip-Seq_TH2_Human2.35118257
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33373187
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.22486004
24SPI1_23547873_ChIP-Seq_NB4_Human2.21987247
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10647693
26GATA3_26560356_Chip-Seq_TH2_Human2.02100395
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99972060
28CIITA_25753668_ChIP-Seq_RAJI_Human1.99386222
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98565340
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96351972
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.93365399
32VDR_21846776_ChIP-Seq_THP-1_Human1.92882617
33MYC_22102868_ChIP-Seq_BL_Human1.92503580
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.87912324
35SCL_19346495_ChIP-Seq_HPC-7_Human1.83766784
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.81917452
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78053258
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73864243
39VDR_24763502_ChIP-Seq_THP-1_Human1.73692480
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73118430
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66232941
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54600547
43SPI1_23127762_ChIP-Seq_K562_Human1.46596733
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45455938
45VDR_23849224_ChIP-Seq_CD4+_Human1.43023851
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40730154
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38041780
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36741157
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29136867
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27648363
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25364938
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23073686
53BCL6_27268052_Chip-Seq_Bcells_Human1.21185939
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19963197
55FOXP3_21729870_ChIP-Seq_TREG_Human1.18391583
56KDM2B_26808549_Chip-Seq_DND41_Human1.17593178
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15303906
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13350065
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11559611
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10994177
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08900417
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08658433
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06609986
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05891330
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05674584
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04628852
67TCF7_22412390_ChIP-Seq_EML_Mouse1.03659843
68BCOR_27268052_Chip-Seq_Bcells_Human1.01566638
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.01032591
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00128901
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93098421
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90036467
73SPI1_20517297_ChIP-Seq_HL60_Human0.89045880
74VDR_24787735_ChIP-Seq_THP-1_Human0.88635847
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88310372
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87325112
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87163487
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86429330
79GATA3_26560356_Chip-Seq_TH1_Human0.86416458
80IGF1R_20145208_ChIP-Seq_DFB_Human0.86259980
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85903337
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84630763
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84513156
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83906472
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83737506
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83601689
87ZNF263_19887448_ChIP-Seq_K562_Human0.83382527
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78782828
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77940843
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77771960
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77536089
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76481954
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75429823
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74974426
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74483824
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74318771
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73397291
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.72582816
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71873699
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71635956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.53957059
2MP0003763_abnormal_thymus_physiology4.81756275
3MP0001835_abnormal_antigen_presentation4.44859770
4MP0009785_altered_susceptibility_to3.58184107
5MP0003045_fibrosis3.45684594
6MP0005000_abnormal_immune_tolerance3.19913877
7MP0001800_abnormal_humoral_immune3.12563421
8MP0003436_decreased_susceptibility_to3.04126397
9MP0005025_abnormal_response_to2.87019149
10MP0001790_abnormal_immune_system2.84659710
11MP0005387_immune_system_phenotype2.84659710
12MP0002420_abnormal_adaptive_immunity2.83102852
13MP0002166_altered_tumor_susceptibility2.74675464
14MP0001819_abnormal_immune_cell2.72672598
15MP0002148_abnormal_hypersensitivity_rea2.70105526
16MP0002723_abnormal_immune_serum2.61586489
17MP0009333_abnormal_splenocyte_physiolog2.45731514
18MP0003866_abnormal_defecation2.38693345
19MP0002405_respiratory_system_inflammati2.38132939
20MP0000685_abnormal_immune_system2.37745107
21MP0002398_abnormal_bone_marrow2.35694255
22MP0002452_abnormal_antigen_presenting2.35435665
23MP0000703_abnormal_thymus_morphology2.35047927
24MP0006082_CNS_inflammation2.23557910
25MP0002006_tumorigenesis2.23073410
26MP0000716_abnormal_immune_system2.18920510
27MP0002419_abnormal_innate_immunity2.18912094
28MP0004381_abnormal_hair_follicle2.17666238
29MP0010155_abnormal_intestine_physiology2.16224774
30MP0003448_altered_tumor_morphology2.08230378
31MP0002722_abnormal_immune_system2.06122604
32MP0005464_abnormal_platelet_physiology1.90524875
33MP0001873_stomach_inflammation1.84667034
34MP0005166_decreased_susceptibility_to1.79887418
35MP0000689_abnormal_spleen_morphology1.77062319
36MP0002429_abnormal_blood_cell1.70753682
37MP0001845_abnormal_inflammatory_respons1.66416590
38MP0003724_increased_susceptibility_to1.65126242
39MP0000465_gastrointestinal_hemorrhage1.64254782
40MP0004947_skin_inflammation1.63155229
41MP0005075_abnormal_melanosome_morpholog1.43718150
42MP0008469_abnormal_protein_level1.20376159
43MP0002396_abnormal_hematopoietic_system1.18757127
44MP0003075_altered_response_to1.17279452
45MP0001533_abnormal_skeleton_physiology1.15506567
46MP0002168_other_aberrant_phenotype1.15462662
47MP0002019_abnormal_tumor_incidence1.12418700
48MP0000604_amyloidosis1.07892612
49MP0005310_abnormal_salivary_gland1.06515955
50MP0009278_abnormal_bone_marrow1.06436028
51MP0003300_gastrointestinal_ulcer1.06427972
52MP0004145_abnormal_muscle_electrophysio1.05327697
53MP0002933_joint_inflammation1.00143358
54MP0002998_abnormal_bone_remodeling0.94955883
55MP0008877_abnormal_DNA_methylation0.94141858
56MP0000858_altered_metastatic_potential0.93533086
57MP0009763_increased_sensitivity_to0.90156001
58MP0000372_irregular_coat_pigmentation0.89623431
59MP0003172_abnormal_lysosome_physiology0.83557191
60MP0001542_abnormal_bone_strength0.80896871
61MP0004883_abnormal_blood_vessel0.78377452
62MP0001853_heart_inflammation0.75444581
63MP0003329_amyloid_beta_deposits0.75170808
64MP0008007_abnormal_cellular_replicative0.74442985
65MP0006035_abnormal_mitochondrial_morpho0.74188371
66MP0001188_hyperpigmentation0.72745538
67MP0002132_abnormal_respiratory_system0.71001662
68MP0005319_abnormal_enzyme/_coenzyme0.69379122
69MP0003690_abnormal_glial_cell0.68130624
70MP0009840_abnormal_foam_cell0.64715540
71MP0009764_decreased_sensitivity_to0.64498237
72MP0010307_abnormal_tumor_latency0.61261700
73MP0005584_abnormal_enzyme/coenzyme_acti0.61007953
74MP0003795_abnormal_bone_structure0.60963742
75MP0008873_increased_physiological_sensi0.60302002
76MP0005084_abnormal_gallbladder_morpholo0.59880160
77MP0001545_abnormal_hematopoietic_system0.59410639
78MP0005397_hematopoietic_system_phenotyp0.59410639
79MP0003786_premature_aging0.57709742
80MP0000920_abnormal_myelination0.57564584
81MP0002277_abnormal_respiratory_mucosa0.57077492
82MP0001851_eye_inflammation0.56892314
83MP0001666_abnormal_nutrient_absorption0.55676522
84MP0005164_abnormal_response_to0.52634432
85MP0002693_abnormal_pancreas_physiology0.52526763
86MP0002876_abnormal_thyroid_physiology0.51347402
87MP0000343_altered_response_to0.51324797
88MP0000477_abnormal_intestine_morphology0.50969296
89MP0001765_abnormal_ion_homeostasis0.50868562
90MP0010094_abnormal_chromosome_stability0.49868623
91MP0004808_abnormal_hematopoietic_stem0.49430238
92MP0009643_abnormal_urine_homeostasis0.48695861
93MP0001919_abnormal_reproductive_system0.48192345
94MP0002083_premature_death0.45942912
95MP0001663_abnormal_digestive_system0.45618625
96MP0002653_abnormal_ependyma_morphology0.43923278
97MP0001502_abnormal_circadian_rhythm0.42614049
98MP0005410_abnormal_fertilization0.41478550
99MP0006036_abnormal_mitochondrial_physio0.41336339
100MP0001905_abnormal_dopamine_level0.40569416

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.03604996
2Abnormality of T cell number (HP:0011839)6.13044373
3Severe combined immunodeficiency (HP:0004430)4.82999313
4Autoimmune hemolytic anemia (HP:0001890)4.81985541
5Abnormality of T cells (HP:0002843)4.78457099
6Recurrent viral infections (HP:0004429)4.64856412
7Hypoproteinemia (HP:0003075)4.63896730
8Aplastic anemia (HP:0001915)4.62628291
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.60810444
10Elevated erythrocyte sedimentation rate (HP:0003565)4.57389798
11Stomatitis (HP:0010280)4.56802265
12IgG deficiency (HP:0004315)4.52576102
13Chronic mucocutaneous candidiasis (HP:0002728)4.52195165
14Recurrent cutaneous fungal infections (HP:0011370)4.52195165
15Increased neuronal autofluorescent lipopigment (HP:0002074)4.47963458
16Abnormality of macrophages (HP:0004311)4.40554100
17Panhypogammaglobulinemia (HP:0003139)4.40531925
18Recurrent fungal infections (HP:0002841)4.37741533
19Thyroiditis (HP:0100646)4.33985505
20Abnormality of eosinophils (HP:0001879)4.32555607
21Hemiplegia (HP:0002301)4.21520637
22Hypoplasia of the thymus (HP:0000778)4.21328620
23Encephalitis (HP:0002383)4.11492054
24Meningitis (HP:0001287)4.11077964
25Eosinophilia (HP:0001880)4.03404141
26Increased cerebral lipofuscin (HP:0011813)3.84685527
27B lymphocytopenia (HP:0010976)3.80791080
28Chronic diarrhea (HP:0002028)3.80742083
29Agammaglobulinemia (HP:0004432)3.79964992
30Leukocytosis (HP:0001974)3.76588620
31Mediastinal lymphadenopathy (HP:0100721)3.76004089
32Combined immunodeficiency (HP:0005387)3.75165764
33Abnormality of B cell number (HP:0010975)3.72064764
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.65550480
35Granulocytopenia (HP:0001913)3.58381059
36Eczematoid dermatitis (HP:0000976)3.37598295
37Myositis (HP:0100614)3.29595375
38Abnormality of the prostate (HP:0008775)3.26303914
39Autoimmune thrombocytopenia (HP:0001973)3.19619887
40Recurrent abscess formation (HP:0002722)3.16627931
41Increased IgM level (HP:0003496)3.11733231
42Renal cortical cysts (HP:0000803)3.06150630
43Chronic obstructive pulmonary disease (HP:0006510)3.00612012
44Obstructive lung disease (HP:0006536)3.00612012
45Abnormality of T cell physiology (HP:0011840)2.97544760
46Recurrent bronchitis (HP:0002837)2.90985566
47Abnormality of the columella (HP:0009929)2.82664713
48Recurrent skin infections (HP:0001581)2.77116979
49Lymphoma (HP:0002665)2.68748278
50Gastrointestinal infarctions (HP:0005244)2.67080489
51Orchitis (HP:0100796)2.58296551
52Retrobulbar optic neuritis (HP:0100654)2.53777274
53Optic neuritis (HP:0100653)2.53777274
54Spontaneous hematomas (HP:0007420)2.50108867
55Lymphopenia (HP:0001888)2.49661017
56Abnormality of oral frenula (HP:0000190)2.46517247
57Vasculitis (HP:0002633)2.40555180
58Recurrent bacterial skin infections (HP:0005406)2.37108298
59Pulmonary infiltrates (HP:0002113)2.36187438
60Visual hallucinations (HP:0002367)2.28527217
61Acute lymphatic leukemia (HP:0006721)2.27598448
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.21420682
63Increased IgE level (HP:0003212)2.20643591
64Prostate neoplasm (HP:0100787)2.20572412
65Chest pain (HP:0100749)2.17902206
66Hypochromic microcytic anemia (HP:0004840)2.17713134
67Hemoptysis (HP:0002105)2.15294291
68Acute hepatic failure (HP:0006554)2.14076265
69Hypergammaglobulinemia (HP:0010702)2.11097431
70Pustule (HP:0200039)2.11020266
71Abnormal albumin level (HP:0012116)2.10169187
72Hypoalbuminemia (HP:0003073)2.10169187
73Increased serum ferritin (HP:0003281)2.09493734
74Recurrent gram-negative bacterial infections (HP:0005420)2.08130642
75Skin rash (HP:0000988)2.04158878
76Clumsiness (HP:0002312)2.02482697
77Centrally nucleated skeletal muscle fibers (HP:0003687)1.97422229
78Papilledema (HP:0001085)1.97272080
79Keratoconjunctivitis (HP:0001096)1.96545991
80Verrucae (HP:0200043)1.96146543
81Papilloma (HP:0012740)1.96146543
82Gingivitis (HP:0000230)1.95646788
83Pulmonary embolism (HP:0002204)1.95565899
84Inflammation of the large intestine (HP:0002037)1.94728446
85Joint swelling (HP:0001386)1.94279974
86Gastrointestinal inflammation (HP:0004386)1.91534883
87Failure to thrive in infancy (HP:0001531)1.90867878
88Tetraplegia (HP:0002445)1.90686749
89Increased intramyocellular lipid droplets (HP:0012240)1.88267190
90Microcytic anemia (HP:0001935)1.86007344
91Pancytopenia (HP:0001876)1.85208415
92Abnormality of iron homeostasis (HP:0011031)1.83365920
93Abnormality of male internal genitalia (HP:0000022)1.82688435
94Testicular atrophy (HP:0000029)1.82631132
95IgM deficiency (HP:0002850)1.81418037
96Urticaria (HP:0001025)1.79054592
97Arterial thrombosis (HP:0004420)1.78675145
98Increased CSF protein (HP:0002922)1.77930813
99Keratoconjunctivitis sicca (HP:0001097)1.76030329
100Increased muscle lipid content (HP:0009058)1.75841587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.28178474
2BCKDK5.24665085
3TXK5.23171570
4ITK3.64387885
5KDR3.00408725
6FES2.62273870
7ZAP702.58737654
8PIK3CG2.29715020
9TESK22.17489887
10NLK2.10766075
11SYK2.09726856
12BTK2.05166354
13KIT1.93532081
14GRK61.87627230
15MAPKAPK31.62261269
16CSK1.61957326
17FLT31.61486476
18TLK11.60246844
19ERN11.59462566
20PRKCQ1.58691453
21LCK1.57684510
22JAK31.51342305
23TEC1.42851468
24EPHA31.42153016
25MAP2K71.41211582
26CSNK1A1L1.38390420
27TYK21.37533445
28MARK31.35790715
29TAOK31.33584492
30JAK21.26975795
31CSNK1G31.26165131
32CSF1R1.18417180
33MAP3K111.13511624
34EIF2AK31.12516472
35PINK11.09829009
36HCK1.07837762
37IKBKB1.04048803
38RIPK41.03379519
39LYN1.03329773
40JAK11.02637356
41IKBKE1.00198391
42MAP3K10.98751914
43IRAK40.92109172
44BLK0.89626859
45PRPF4B0.89551911
46CAMKK20.86762299
47EPHB10.85488146
48FGFR40.84412907
49NME20.83448338
50CSNK1G10.81462074
51FGFR30.79832962
52HIPK20.79591455
53MAPK110.76348740
54CSNK1G20.74885851
55TNK20.70391478
56FRK0.68791078
57MAP3K140.65594440
58TBK10.64605226
59MAPK120.62846089
60RPS6KA40.59633974
61FYN0.57635105
62PIM10.55446493
63TGFBR20.55353316
64TGFBR10.55281268
65ALK0.52975293
66BMPR20.52957650
67RPS6KB10.52080635
68CSNK1A10.47349527
69PDK10.47129496
70RPS6KA50.44226469
71ZAK0.42346941
72DAPK10.41754556
73PRKCH0.40465414
74MAPK30.39553135
75MAPKAPK20.39315747
76NEK20.38617922
77RET0.36211907
78IRAK10.35131328
79MAP3K50.31632292
80MATK0.30925510
81MAP2K30.29584773
82IGF1R0.28384785
83MAPK90.27098502
84ADRBK20.27026078
85CAMKK10.25046010
86STK100.22854556
87INSR0.20151408
88GSK3A0.20020717
89CDK120.19719746
90CSNK2A10.18630855
91AURKA0.17667816
92GRK10.16861035
93CSNK2A20.16672559
94PRKCD0.16293647
95MAP3K30.16287590
96TIE10.14723977
97CSNK1D0.14062071
98RPS6KA10.12523332
99EGFR0.12417869
100CHUK0.11216733

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.32408584
2Allograft rejection_Homo sapiens_hsa053304.39638659
3Autoimmune thyroid disease_Homo sapiens_hsa053204.22603507
4Graft-versus-host disease_Homo sapiens_hsa053324.19289499
5Type I diabetes mellitus_Homo sapiens_hsa049403.41054671
6T cell receptor signaling pathway_Homo sapiens_hsa046602.89745180
7Proteasome_Homo sapiens_hsa030502.77109603
8Antigen processing and presentation_Homo sapiens_hsa046122.76295701
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.60049571
10Hematopoietic cell lineage_Homo sapiens_hsa046402.38079758
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04674866
12Measles_Homo sapiens_hsa051621.96213915
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.79580604
14Viral myocarditis_Homo sapiens_hsa054161.76561441
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75535127
16Acute myeloid leukemia_Homo sapiens_hsa052211.62154581
17B cell receptor signaling pathway_Homo sapiens_hsa046621.61067480
18Asthma_Homo sapiens_hsa053101.53631256
19Leishmaniasis_Homo sapiens_hsa051401.52813876
20Herpes simplex infection_Homo sapiens_hsa051681.47629489
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38851253
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.37463372
23Osteoclast differentiation_Homo sapiens_hsa043801.36153482
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31724473
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.29959487
26Phototransduction_Homo sapiens_hsa047441.24701993
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12319043
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11086609
29Apoptosis_Homo sapiens_hsa042101.10542085
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09496770
31Protein export_Homo sapiens_hsa030601.06699952
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03978522
33Rheumatoid arthritis_Homo sapiens_hsa053231.03799687
34Staphylococcus aureus infection_Homo sapiens_hsa051501.00554628
35Sulfur metabolism_Homo sapiens_hsa009200.99507414
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99327351
37Systemic lupus erythematosus_Homo sapiens_hsa053220.99066014
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98532991
39Chemokine signaling pathway_Homo sapiens_hsa040620.96960851
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96735490
41Steroid biosynthesis_Homo sapiens_hsa001000.91917916
42Influenza A_Homo sapiens_hsa051640.89428647
43Malaria_Homo sapiens_hsa051440.88936371
44Olfactory transduction_Homo sapiens_hsa047400.87643631
45Tuberculosis_Homo sapiens_hsa051520.84216305
46Shigellosis_Homo sapiens_hsa051310.83173371
47HTLV-I infection_Homo sapiens_hsa051660.82398256
48Epstein-Barr virus infection_Homo sapiens_hsa051690.81687571
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81550234
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78175162
51Homologous recombination_Homo sapiens_hsa034400.76925253
52Toxoplasmosis_Homo sapiens_hsa051450.76051748
53Viral carcinogenesis_Homo sapiens_hsa052030.72686189
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70890983
55TNF signaling pathway_Homo sapiens_hsa046680.69866011
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66013319
57Hepatitis B_Homo sapiens_hsa051610.64056718
58Regulation of autophagy_Homo sapiens_hsa041400.58045390
59Platelet activation_Homo sapiens_hsa046110.56320351
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53957743
61Legionellosis_Homo sapiens_hsa051340.53627237
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53484690
63Non-small cell lung cancer_Homo sapiens_hsa052230.52095471
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51087183
65Pyrimidine metabolism_Homo sapiens_hsa002400.51054179
66Spliceosome_Homo sapiens_hsa030400.50814325
67Other glycan degradation_Homo sapiens_hsa005110.48552187
68Hepatitis C_Homo sapiens_hsa051600.47004509
69Pertussis_Homo sapiens_hsa051330.44894589
70Phagosome_Homo sapiens_hsa041450.43595132
71African trypanosomiasis_Homo sapiens_hsa051430.40512917
72Selenocompound metabolism_Homo sapiens_hsa004500.40230392
73RNA polymerase_Homo sapiens_hsa030200.38283748
74Fanconi anemia pathway_Homo sapiens_hsa034600.36692861
75Alcoholism_Homo sapiens_hsa050340.36318662
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32885645
77DNA replication_Homo sapiens_hsa030300.32838993
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.29730356
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.29009949
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28958778
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27501169
82Glioma_Homo sapiens_hsa052140.26801610
83Oxytocin signaling pathway_Homo sapiens_hsa049210.26165486
84Long-term potentiation_Homo sapiens_hsa047200.24416652
85Chronic myeloid leukemia_Homo sapiens_hsa052200.24243538
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.22972055
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.22796638
88Pancreatic cancer_Homo sapiens_hsa052120.22696298
89Lysosome_Homo sapiens_hsa041420.22602375
90Endocytosis_Homo sapiens_hsa041440.21615566
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20614008
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20286025
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19602079
94Renin secretion_Homo sapiens_hsa049240.17329708
95Nitrogen metabolism_Homo sapiens_hsa009100.16139601
96Salmonella infection_Homo sapiens_hsa051320.14397513
97Prolactin signaling pathway_Homo sapiens_hsa049170.13651756
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12911786
99Dorso-ventral axis formation_Homo sapiens_hsa043200.12285787
100Taste transduction_Homo sapiens_hsa047420.11720433

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