TRBV24-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)6.63148294
2regulation of B cell receptor signaling pathway (GO:0050855)6.08707194
3positive T cell selection (GO:0043368)6.04642040
4response to interleukin-15 (GO:0070672)5.87159977
5negative T cell selection (GO:0043383)5.76302026
6negative thymic T cell selection (GO:0045060)5.72064872
7tolerance induction (GO:0002507)5.61347957
8cellular response to interleukin-15 (GO:0071350)5.59864144
9thymic T cell selection (GO:0045061)5.58363280
10antigen processing and presentation via MHC class Ib (GO:0002475)5.52295303
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.39716309
12negative regulation of cell killing (GO:0031342)5.39716309
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.27397874
14T cell selection (GO:0045058)5.19734013
15regulation of regulatory T cell differentiation (GO:0045589)5.17899860
16positive regulation of gamma-delta T cell activation (GO:0046645)5.05196485
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.88671620
18regulation of isotype switching to IgG isotypes (GO:0048302)4.69014497
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.66837690
20cellular response to type I interferon (GO:0071357)4.65022255
21type I interferon signaling pathway (GO:0060337)4.65022255
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.64082020
23response to type I interferon (GO:0034340)4.58946409
24antigen processing and presentation of endogenous antigen (GO:0019883)4.57494365
25T cell receptor signaling pathway (GO:0050852)4.43696852
26response to interferon-beta (GO:0035456)4.37217486
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26726152
28antigen receptor-mediated signaling pathway (GO:0050851)4.19607381
29cellular response to interferon-beta (GO:0035458)4.18246748
30leukocyte aggregation (GO:0070486)4.13566773
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.11228300
32T cell costimulation (GO:0031295)4.10688377
33lymphocyte costimulation (GO:0031294)4.04931929
34interferon-gamma-mediated signaling pathway (GO:0060333)4.04196948
35hepatocyte apoptotic process (GO:0097284)3.91594660
36negative regulation of interleukin-12 production (GO:0032695)3.87794281
37regulation of T cell tolerance induction (GO:0002664)3.80885741
38negative regulation of T cell mediated immunity (GO:0002710)3.79967708
39regulation of gamma-delta T cell differentiation (GO:0045586)3.74549775
40detection of bacterium (GO:0016045)3.73170438
41T cell migration (GO:0072678)3.71230306
42positive regulation of B cell differentiation (GO:0045579)3.70555106
43regulation of gamma-delta T cell activation (GO:0046643)3.64035762
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.61406223
45positive regulation of defense response to virus by host (GO:0002230)3.54921287
46natural killer cell differentiation (GO:0001779)3.54868473
47detection of other organism (GO:0098543)3.48147907
48regulation of alpha-beta T cell proliferation (GO:0046640)3.43316299
49positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.42343150
50negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.41280320
51interferon-gamma production (GO:0032609)3.40690893
52positive regulation of interleukin-2 production (GO:0032743)3.39495331
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.38716626
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37252506
55positive regulation of granulocyte differentiation (GO:0030854)3.37122991
56granulocyte activation (GO:0036230)3.36538047
57regulation of interleukin-1 beta secretion (GO:0050706)3.32681687
58positive regulation of interleukin-1 beta secretion (GO:0050718)3.32291096
59immunoglobulin mediated immune response (GO:0016064)3.27475755
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26222345
61megakaryocyte development (GO:0035855)3.25194401
62regulation of type I interferon-mediated signaling pathway (GO:0060338)3.24224942
63negative regulation of innate immune response (GO:0045824)3.24205529
64mast cell activation (GO:0045576)3.22125498
65positive regulation of protein oligomerization (GO:0032461)3.21835749
66cellular response to interferon-gamma (GO:0071346)3.17065093
67neutrophil activation involved in immune response (GO:0002283)3.15081506
68positive regulation of tolerance induction (GO:0002645)3.12646190
69regulation of tolerance induction (GO:0002643)3.12531654
70positive regulation of interleukin-1 secretion (GO:0050716)3.10970381
71leukocyte degranulation (GO:0043299)3.08973791
72regulation of B cell differentiation (GO:0045577)3.06417691
73regulation of T cell mediated cytotoxicity (GO:0001914)3.05900511
74negative regulation of leukocyte mediated immunity (GO:0002704)3.05070970
75negative regulation of T cell apoptotic process (GO:0070233)3.02777515
76angiogenesis involved in wound healing (GO:0060055)2.99218531
77T cell homeostasis (GO:0043029)2.96839536
78positive regulation by symbiont of host defense response (GO:0052509)2.96387945
79modulation by symbiont of host defense response (GO:0052031)2.96387945
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96387945
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96387945
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.96387945
83modulation by symbiont of host immune response (GO:0052553)2.96387945
84cellular defense response (GO:0006968)2.95630021
85alpha-beta T cell differentiation (GO:0046632)2.94017500
86activated T cell proliferation (GO:0050798)2.93863830
87regulation of T cell receptor signaling pathway (GO:0050856)2.93806531
88regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.93639343
89regulation of alpha-beta T cell activation (GO:0046634)2.93591839
90myeloid cell activation involved in immune response (GO:0002275)2.92221616
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90122178
92regulation of interleukin-1 secretion (GO:0050704)2.89604034
93negative regulation of viral genome replication (GO:0045071)2.89248272
94negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88542230
95negative regulation of T-helper cell differentiation (GO:0045623)2.86804869
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86804869
97detection of external biotic stimulus (GO:0098581)2.86717421
98immune response-activating cell surface receptor signaling pathway (GO:0002429)2.85824221
99regulation of isotype switching (GO:0045191)2.84583535
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83513808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.62798213
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.56339561
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.68420459
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.53652664
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.48401131
6RUNX_20019798_ChIP-Seq_JUKART_Human4.00446758
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95117137
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.42021280
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17573525
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12391274
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98064818
12MYB_26560356_Chip-Seq_TH2_Human2.97314004
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.79143666
14MYB_26560356_Chip-Seq_TH1_Human2.76245791
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71878412
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.51033049
17MAF_26560356_Chip-Seq_TH1_Human2.42360637
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41904190
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40508606
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32904260
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.23359869
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14428347
23GATA3_27048872_Chip-Seq_THYMUS_Human2.14035807
24SCL_19346495_ChIP-Seq_HPC-7_Human2.13303499
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11838999
26UTX_26944678_Chip-Seq_JUKART_Human2.09517221
27SPI1_23547873_ChIP-Seq_NB4_Human2.08224762
28GATA3_26560356_Chip-Seq_TH2_Human2.02856656
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91394305
30SPI1_23127762_ChIP-Seq_K562_Human1.81006202
31MAF_26560356_Chip-Seq_TH2_Human1.78613024
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75276364
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73713134
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67728575
35VDR_24787735_ChIP-Seq_THP-1_Human1.63632955
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62499784
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61738623
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.53672519
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52880993
40VDR_24763502_ChIP-Seq_THP-1_Human1.48075897
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46679094
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.44398464
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42515717
44CIITA_25753668_ChIP-Seq_RAJI_Human1.41279880
45IRF1_19129219_ChIP-ChIP_H3396_Human1.40773709
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38076279
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34487035
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31569774
49EGR1_19032775_ChIP-ChIP_M12_Human1.31496564
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30370275
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30051920
52FOXP3_21729870_ChIP-Seq_TREG_Human1.29489431
53VDR_23849224_ChIP-Seq_CD4+_Human1.28026680
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23956983
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23493918
56MYC_22102868_ChIP-Seq_BL_Human1.20970878
57VDR_21846776_ChIP-Seq_THP-1_Human1.20002232
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17478583
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12305875
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.12100462
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10931626
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08425528
63PU_27001747_Chip-Seq_BMDM_Mouse1.08177645
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06963619
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04175916
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04058327
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02738445
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02600616
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01324964
70NFE2_27457419_Chip-Seq_LIVER_Mouse0.98957731
71GATA1_19941827_ChIP-Seq_MEL_Mouse0.93186837
72TCF7_22412390_ChIP-Seq_EML_Mouse0.92125255
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92112029
74PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91913583
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90717275
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89564024
77GATA3_26560356_Chip-Seq_TH1_Human0.89538899
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89172471
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.87983872
80SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85849994
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85079678
82SMRT_27268052_Chip-Seq_Bcells_Human0.82603750
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82017375
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81176324
85BCL6_27268052_Chip-Seq_Bcells_Human0.80593458
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77887846
87KDM2B_26808549_Chip-Seq_DND41_Human0.76866458
88SPI1_20517297_ChIP-Seq_HL60_Human0.76529974
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76377185
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74939566
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73954312
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72667772
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70259071
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70112319
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69960324
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.69411796
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69318449
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68904932
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68194628
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.66792238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.69031903
2MP0003763_abnormal_thymus_physiology3.81445298
3MP0000569_abnormal_digit_pigmentation3.57962758
4MP0001835_abnormal_antigen_presentation3.54235422
5MP0001800_abnormal_humoral_immune3.27140360
6MP0001790_abnormal_immune_system3.13362435
7MP0005387_immune_system_phenotype3.13362435
8MP0003436_decreased_susceptibility_to2.96636122
9MP0005000_abnormal_immune_tolerance2.94225334
10MP0009840_abnormal_foam_cell2.91585189
11MP0009785_altered_susceptibility_to2.88076243
12MP0002166_altered_tumor_susceptibility2.72983368
13MP0002723_abnormal_immune_serum2.70730042
14MP0005025_abnormal_response_to2.68790858
15MP0001873_stomach_inflammation2.67028850
16MP0003724_increased_susceptibility_to2.63398601
17MP0002452_abnormal_antigen_presenting2.56685694
18MP0003300_gastrointestinal_ulcer2.55825025
19MP0002420_abnormal_adaptive_immunity2.52550779
20MP0005075_abnormal_melanosome_morpholog2.52540309
21MP0001819_abnormal_immune_cell2.50754117
22MP0002148_abnormal_hypersensitivity_rea2.48000876
23MP0002405_respiratory_system_inflammati2.41948686
24MP0009333_abnormal_splenocyte_physiolog2.34168886
25MP0000685_abnormal_immune_system2.27889973
26MP0002398_abnormal_bone_marrow2.20241952
27MP0006082_CNS_inflammation2.19127898
28MP0002009_preneoplasia2.17653884
29MP0000703_abnormal_thymus_morphology2.14424046
30MP0000716_abnormal_immune_system2.11448133
31MP0002419_abnormal_innate_immunity2.05331761
32MP0002102_abnormal_ear_morphology2.00383845
33MP0005464_abnormal_platelet_physiology1.98524938
34MP0002006_tumorigenesis1.97055616
35MP0003866_abnormal_defecation1.88669142
36MP0005310_abnormal_salivary_gland1.83382208
37MP0009764_decreased_sensitivity_to1.81964579
38MP0002933_joint_inflammation1.80484641
39MP0001845_abnormal_inflammatory_respons1.78109090
40MP0000689_abnormal_spleen_morphology1.77592096
41MP0010155_abnormal_intestine_physiology1.74102850
42MP0000015_abnormal_ear_pigmentation1.73832647
43MP0003303_peritoneal_inflammation1.72190353
44MP0002722_abnormal_immune_system1.70484121
45MP0002429_abnormal_blood_cell1.63686279
46MP0003787_abnormal_imprinting1.54785864
47MP0000465_gastrointestinal_hemorrhage1.51153187
48MP0001533_abnormal_skeleton_physiology1.46540743
49MP0004947_skin_inflammation1.39992796
50MP0003172_abnormal_lysosome_physiology1.39108636
51MP0008469_abnormal_protein_level1.25829827
52MP0002877_abnormal_melanocyte_morpholog1.18899878
53MP0008877_abnormal_DNA_methylation1.18159381
54MP0001853_heart_inflammation1.12626516
55MP0005058_abnormal_lysosome_morphology1.09955641
56MP0001851_eye_inflammation1.06097196
57MP0004381_abnormal_hair_follicle1.05092394
58MP0002332_abnormal_exercise_endurance1.04146456
59MP0002277_abnormal_respiratory_mucosa1.01149933
60MP0002138_abnormal_hepatobiliary_system0.98808409
61MP0003806_abnormal_nucleotide_metabolis0.95649435
62MP0005174_abnormal_tail_pigmentation0.88790382
63MP0002998_abnormal_bone_remodeling0.88166453
64MP0000371_diluted_coat_color0.86799611
65MP0000604_amyloidosis0.84474580
66MP0002693_abnormal_pancreas_physiology0.83484140
67MP0003045_fibrosis0.81742350
68MP0003221_abnormal_cardiomyocyte_apopto0.81690338
69MP0000858_altered_metastatic_potential0.80744159
70MP0002396_abnormal_hematopoietic_system0.79977152
71MP0001663_abnormal_digestive_system0.79088682
72MP0008260_abnormal_autophagy0.77658988
73MP0003448_altered_tumor_morphology0.76498382
74MP0009763_increased_sensitivity_to0.74660459
75MP0005670_abnormal_white_adipose0.66753611
76MP0004510_myositis0.64780607
77MP0002132_abnormal_respiratory_system0.59715169
78MP0005166_decreased_susceptibility_to0.57505067
79MP0005319_abnormal_enzyme/_coenzyme0.57213313
80MP0005390_skeleton_phenotype0.54925350
81MP0003075_altered_response_to0.54361706
82MP0000249_abnormal_blood_vessel0.53366037
83MP0005365_abnormal_bile_salt0.53029769
84MP0006036_abnormal_mitochondrial_physio0.51837508
85MP0008873_increased_physiological_sensi0.49775643
86MP0003191_abnormal_cellular_cholesterol0.49015068
87MP0003646_muscle_fatigue0.47119554
88MP0002136_abnormal_kidney_physiology0.44676688
89MP0003315_abnormal_perineum_morphology0.44514828
90MP0001348_abnormal_lacrimal_gland0.43916072
91MP0002163_abnormal_gland_morphology0.43573481
92MP0002019_abnormal_tumor_incidence0.40868771
93MP0005266_abnormal_metabolism0.40636371
94MP0001243_abnormal_dermal_layer0.39774039
95MP0005408_hypopigmentation0.39769922
96MP0000609_abnormal_liver_physiology0.38068100
97MP0000920_abnormal_myelination0.36531242
98MP0005381_digestive/alimentary_phenotyp0.36310490
99MP0009278_abnormal_bone_marrow0.36183223
100MP0009765_abnormal_xenobiotic_induced0.35855328

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)7.03929018
2Stomatitis (HP:0010280)5.91468384
3Elevated erythrocyte sedimentation rate (HP:0003565)4.83517414
4Gastrointestinal infarctions (HP:0005244)4.42319658
5Abnormality of the prostate (HP:0008775)4.28605079
6Pulmonary infiltrates (HP:0002113)4.24355841
7IgG deficiency (HP:0004315)4.23439423
8Obstructive lung disease (HP:0006536)4.11531088
9Chronic obstructive pulmonary disease (HP:0006510)4.11531088
10Meningitis (HP:0001287)4.03974703
11Hemoptysis (HP:0002105)3.90690472
12Chest pain (HP:0100749)3.88439972
13Papilledema (HP:0001085)3.84044407
14Eczematoid dermatitis (HP:0000976)3.78784337
15Mediastinal lymphadenopathy (HP:0100721)3.74085155
16T lymphocytopenia (HP:0005403)3.64399050
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.61534323
18Abnormality of T cell number (HP:0011839)3.58737559
19Albinism (HP:0001022)3.48924115
20IgM deficiency (HP:0002850)3.37417916
21Vasculitis (HP:0002633)3.36350928
22Abnormality of T cells (HP:0002843)3.35779032
23Recurrent abscess formation (HP:0002722)3.27022841
24Encephalitis (HP:0002383)3.25185811
25Recurrent fungal infections (HP:0002841)3.24010458
26Recurrent bacterial skin infections (HP:0005406)3.21820042
27Chronic diarrhea (HP:0002028)3.21193582
28Pulmonary fibrosis (HP:0002206)3.20285458
29Panhypogammaglobulinemia (HP:0003139)3.17376677
30Myositis (HP:0100614)3.13656189
31Pulmonary embolism (HP:0002204)3.09084625
32Ureteral stenosis (HP:0000071)3.05478299
33Joint swelling (HP:0001386)3.03745289
34Retrobulbar optic neuritis (HP:0100654)3.01292192
35Optic neuritis (HP:0100653)3.01292192
36Abnormality of macrophages (HP:0004311)2.99127099
37Increased IgM level (HP:0003496)2.94006477
38Ureteral obstruction (HP:0006000)2.88197593
39Gangrene (HP:0100758)2.86266440
40Recurrent cutaneous fungal infections (HP:0011370)2.83686471
41Chronic mucocutaneous candidiasis (HP:0002728)2.83686471
42Orchitis (HP:0100796)2.82830090
43Lymphopenia (HP:0001888)2.80530132
44Eosinophilia (HP:0001880)2.78715307
45Abnormality of eosinophils (HP:0001879)2.78557493
46Abnormality of the pleura (HP:0002103)2.76379439
47Severe combined immunodeficiency (HP:0004430)2.74662971
48Verrucae (HP:0200043)2.71737645
49Papilloma (HP:0012740)2.71737645
50Abnormality of T cell physiology (HP:0011840)2.70505953
51Spondylolisthesis (HP:0003302)2.69958502
52Spontaneous hematomas (HP:0007420)2.68112694
53Pustule (HP:0200039)2.63745432
54Epistaxis (HP:0000421)2.63135445
55Fair hair (HP:0002286)2.61662659
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.60796582
57Leukocytosis (HP:0001974)2.59564483
58Granulocytopenia (HP:0001913)2.57623697
59Recurrent bronchitis (HP:0002837)2.55321394
60Skin rash (HP:0000988)2.54664983
61IgA deficiency (HP:0002720)2.52089866
62Respiratory difficulties (HP:0002880)2.51377433
63Agammaglobulinemia (HP:0004432)2.47592533
64Recurrent skin infections (HP:0001581)2.47300267
65Abnormality of male internal genitalia (HP:0000022)2.43178518
66Glomerulopathy (HP:0100820)2.38093959
67Abnormality of glycolipid metabolism (HP:0010969)2.37342308
68Abnormality of liposaccharide metabolism (HP:0010968)2.37342308
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.37342308
70Prolonged bleeding time (HP:0003010)2.37328875
71Autoimmune thrombocytopenia (HP:0001973)2.35896352
72Premature loss of primary teeth (HP:0006323)2.33802225
73Increased hepatocellular lipid droplets (HP:0006565)2.33759938
74Keratoconjunctivitis sicca (HP:0001097)2.33100301
75Axonal loss (HP:0003447)2.32590103
76Abnormality of the pericardium (HP:0001697)2.30381760
77Keratitis (HP:0000491)2.30214656
78Hypoproteinemia (HP:0003075)2.28428476
79Lipid accumulation in hepatocytes (HP:0006561)2.25131267
80Polyneuropathy (HP:0001271)2.21923313
81Arterial thrombosis (HP:0004420)2.20326185
82Urticaria (HP:0001025)2.20247066
83Mucosal telangiectasiae (HP:0100579)2.19553538
84Abnormality of the fingertips (HP:0001211)2.17985149
85Hypochromic anemia (HP:0001931)2.17524354
86Recurrent viral infections (HP:0004429)2.14419287
87Keratoconjunctivitis (HP:0001096)2.14365548
88Generalized hypopigmentation of hair (HP:0011358)2.13350368
89Gingivitis (HP:0000230)2.11992416
90Restrictive lung disease (HP:0002091)2.09447262
91Hip dysplasia (HP:0001385)2.09279188
92Periodontitis (HP:0000704)2.07804866
93Slow saccadic eye movements (HP:0000514)2.07690518
94Ocular albinism (HP:0001107)2.07113026
95Hypochromic microcytic anemia (HP:0004840)2.06946845
96Systemic lupus erythematosus (HP:0002725)2.06167047
97Abnormality of binocular vision (HP:0011514)2.04754758
98Diplopia (HP:0000651)2.04754758
99Exertional dyspnea (HP:0002875)2.03118047
100Combined immunodeficiency (HP:0005387)2.01791544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.21935386
2MAP4K14.42739286
3DMPK3.38168715
4JAK33.19802945
5ITK2.98402577
6TYK22.92371018
7FES2.54879192
8TNK22.42929419
9BTK2.22175760
10IKBKE2.10595973
11MST42.10002230
12LCK2.03044241
13JAK11.86046676
14TEC1.84887618
15STK161.84236082
16RIPK41.82653335
17ZAP701.82021287
18SIK31.81368474
19HCK1.79861741
20SYK1.71967985
21MAP3K121.47762081
22LYN1.46176991
23IKBKB1.41764402
24CSK1.41162356
25FGFR41.40404686
26FGFR31.31071272
27IRAK41.26660192
28KIT1.26035015
29CAMKK21.26020934
30GRK61.24224974
31EIF2AK11.22270272
32TBK11.20079922
33JAK21.19477767
34BLK1.16816056
35FYN1.15029250
36CDK41.05404894
37TRIM281.04606606
38NLK0.99424873
39CDK80.93282279
40CSF1R0.89546127
41TAOK30.88974339
42CDK60.87343656
43STK100.86717583
44PASK0.82930537
45MAPKAPK30.80282740
46RPS6KC10.78789595
47RPS6KL10.78789595
48MAP3K140.76523703
49RPS6KA50.75609888
50IGF1R0.75304049
51CAMKK10.75035375
52MARK30.74586615
53RPS6KA60.74263298
54MAP2K30.73377163
55TLK10.71616087
56PRKCQ0.71510311
57MELK0.69507268
58CDK90.68763146
59BRD40.66845453
60CLK10.66546428
61MAP3K110.66404169
62IRAK10.63816025
63ZAK0.63400114
64ADRBK20.58145087
65PIK3CG0.57094730
66GRK70.55244283
67PIM10.55087173
68FGFR20.53180251
69EPHB10.53073024
70IRAK20.53014655
71PRPF4B0.52917122
72RPS6KA20.52311675
73PTK2B0.51685386
74SIK20.50940617
75MAPK110.50274860
76MAP3K30.49753590
77SGK30.47580691
78MAP3K130.47479212
79MAPKAPK20.45378954
80OXSR10.43141027
81BUB10.41941010
82MAP2K60.38717416
83STK380.38225719
84MATK0.37655571
85MAPK120.37366640
86CDK30.37225571
87TYRO30.36604820
88STK240.36286407
89PRKCH0.33937850
90LRRK20.33585227
91EGFR0.33559427
92PDK10.31670785
93GRK50.29916129
94RET0.29909696
95CSNK1D0.29580365
96FRK0.28517758
97BCR0.27155882
98FGR0.26898093
99STK390.26275994
100PIK3CA0.24973135

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.31306883
2Allograft rejection_Homo sapiens_hsa053304.11316886
3Graft-versus-host disease_Homo sapiens_hsa053323.95824729
4Primary immunodeficiency_Homo sapiens_hsa053403.60270911
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.21692770
6T cell receptor signaling pathway_Homo sapiens_hsa046603.09310654
7Type I diabetes mellitus_Homo sapiens_hsa049403.08419838
8Antigen processing and presentation_Homo sapiens_hsa046122.90440809
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.73122779
10Asthma_Homo sapiens_hsa053102.70910132
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53506535
12Measles_Homo sapiens_hsa051622.47855052
13Staphylococcus aureus infection_Homo sapiens_hsa051502.39487924
14Viral myocarditis_Homo sapiens_hsa054162.37970211
15Hematopoietic cell lineage_Homo sapiens_hsa046402.18083631
16Leishmaniasis_Homo sapiens_hsa051402.09783009
17Osteoclast differentiation_Homo sapiens_hsa043802.03373501
18Chemokine signaling pathway_Homo sapiens_hsa040621.84393067
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70263976
20B cell receptor signaling pathway_Homo sapiens_hsa046621.64082573
21Rheumatoid arthritis_Homo sapiens_hsa053231.62916218
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.60454652
23Herpes simplex infection_Homo sapiens_hsa051681.58801841
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55270947
25Toxoplasmosis_Homo sapiens_hsa051451.46579624
26Proteasome_Homo sapiens_hsa030501.46222567
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.40939991
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38874732
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32808208
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27460306
31Influenza A_Homo sapiens_hsa051641.23279379
32Tuberculosis_Homo sapiens_hsa051521.20034200
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17184274
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09095687
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04874040
36HTLV-I infection_Homo sapiens_hsa051661.02125831
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01498201
38Hepatitis B_Homo sapiens_hsa051610.98437187
39Epstein-Barr virus infection_Homo sapiens_hsa051690.97003014
40Acute myeloid leukemia_Homo sapiens_hsa052210.91540858
41Non-small cell lung cancer_Homo sapiens_hsa052230.90446330
42Viral carcinogenesis_Homo sapiens_hsa052030.88450327
43Shigellosis_Homo sapiens_hsa051310.86821364
44Platelet activation_Homo sapiens_hsa046110.81199779
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80849238
46Legionellosis_Homo sapiens_hsa051340.79486264
47Regulation of autophagy_Homo sapiens_hsa041400.78903816
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78166151
49Pertussis_Homo sapiens_hsa051330.78042628
50TNF signaling pathway_Homo sapiens_hsa046680.77741627
51Hepatitis C_Homo sapiens_hsa051600.76232176
52Pancreatic cancer_Homo sapiens_hsa052120.72788497
53Phagosome_Homo sapiens_hsa041450.70776815
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69994983
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65821433
56Apoptosis_Homo sapiens_hsa042100.64867942
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.64233587
58Inositol phosphate metabolism_Homo sapiens_hsa005620.60197282
59Endocytosis_Homo sapiens_hsa041440.55722889
60Dorso-ventral axis formation_Homo sapiens_hsa043200.55087954
61Systemic lupus erythematosus_Homo sapiens_hsa053220.52641105
62Lysosome_Homo sapiens_hsa041420.52581353
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51434217
64Malaria_Homo sapiens_hsa051440.50674110
65VEGF signaling pathway_Homo sapiens_hsa043700.48558665
66MAPK signaling pathway_Homo sapiens_hsa040100.37303969
67Nitrogen metabolism_Homo sapiens_hsa009100.35465313
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34488673
69Prolactin signaling pathway_Homo sapiens_hsa049170.33198964
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30315217
71African trypanosomiasis_Homo sapiens_hsa051430.29140390
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.29111353
73Chronic myeloid leukemia_Homo sapiens_hsa052200.29062811
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28158817
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26633167
76Linoleic acid metabolism_Homo sapiens_hsa005910.26428255
77Basal transcription factors_Homo sapiens_hsa030220.26037321
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.24647174
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22118974
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.21464504
81Choline metabolism in cancer_Homo sapiens_hsa052310.21024622
82Fructose and mannose metabolism_Homo sapiens_hsa000510.18473291
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17863293
84Parkinsons disease_Homo sapiens_hsa050120.16846718
85Salmonella infection_Homo sapiens_hsa051320.15005060
86Olfactory transduction_Homo sapiens_hsa047400.13990386
87FoxO signaling pathway_Homo sapiens_hsa040680.11370299
88Ras signaling pathway_Homo sapiens_hsa040140.10764674
89Renal cell carcinoma_Homo sapiens_hsa052110.09730391
90Caffeine metabolism_Homo sapiens_hsa002320.09679320
91Pentose phosphate pathway_Homo sapiens_hsa000300.09161289
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08601904
93Insulin resistance_Homo sapiens_hsa049310.07585351
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.06593423
95Small cell lung cancer_Homo sapiens_hsa052220.05568497
96RNA degradation_Homo sapiens_hsa030180.05442207
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.04405517
98Notch signaling pathway_Homo sapiens_hsa043300.03248321
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02444995
100Prostate cancer_Homo sapiens_hsa052150.01842894

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