TRBV20OR9-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)8.57053957
2positive regulation of natural killer cell mediated immunity (GO:0002717)8.29391784
3regulation of B cell receptor signaling pathway (GO:0050855)7.61777421
4regulation of natural killer cell mediated immunity (GO:0002715)7.17756480
5regulation of natural killer cell mediated cytotoxicity (GO:0042269)7.17756480
6Arp2/3 complex-mediated actin nucleation (GO:0034314)7.14966751
7negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.79180275
8actin nucleation (GO:0045010)6.27905752
9erythrocyte maturation (GO:0043249)5.62654013
10positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.47955466
11negative regulation of execution phase of apoptosis (GO:1900118)5.38427801
12fusion of sperm to egg plasma membrane (GO:0007342)5.30034960
13erythrocyte development (GO:0048821)4.97347104
14cytolysis (GO:0019835)4.96751329
15regulation of leukocyte mediated cytotoxicity (GO:0001910)4.95993120
16sphingomyelin metabolic process (GO:0006684)4.93438465
17positive regulation of cell killing (GO:0031343)4.81411789
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69907923
19sulfation (GO:0051923)4.68188253
20positive thymic T cell selection (GO:0045059)4.61156535
21positive T cell selection (GO:0043368)4.47931273
22mast cell degranulation (GO:0043303)4.45778402
23mast cell activation involved in immune response (GO:0002279)4.45778402
24negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.38338941
25regulation of cell killing (GO:0031341)4.36260697
26iron-sulfur cluster assembly (GO:0016226)4.35045196
27metallo-sulfur cluster assembly (GO:0031163)4.35045196
28cellular response to interleukin-15 (GO:0071350)4.30322322
29negative regulation of monooxygenase activity (GO:0032769)4.27818623
30cytidine deamination (GO:0009972)4.22573024
31cytidine metabolic process (GO:0046087)4.22573024
32cytidine catabolic process (GO:0006216)4.22573024
33protoporphyrinogen IX metabolic process (GO:0046501)4.22304652
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18292387
35auditory receptor cell differentiation (GO:0042491)4.09223078
36positive regulation of interleukin-8 secretion (GO:2000484)4.08733085
37regulation of transmission of nerve impulse (GO:0051969)3.98117008
38oxygen transport (GO:0015671)3.96854023
39natural killer cell activation (GO:0030101)3.96410857
40hemoglobin metabolic process (GO:0020027)3.94689205
41plasma membrane fusion (GO:0045026)3.93882369
42negative regulation of stress fiber assembly (GO:0051497)3.87098303
43deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.86930551
44negative regulation of oxidoreductase activity (GO:0051354)3.85624330
45negative T cell selection (GO:0043383)3.85506375
46protein maturation by protein folding (GO:0022417)3.84601218
47pyrimidine ribonucleoside catabolic process (GO:0046133)3.83241953
48mitochondrial calcium ion transport (GO:0006851)3.78795222
49DNA deamination (GO:0045006)3.78190511
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.75036964
51termination of RNA polymerase III transcription (GO:0006386)3.75036964
52regulation of interleukin-8 secretion (GO:2000482)3.73285424
53thymic T cell selection (GO:0045061)3.72347631
54mast cell activation (GO:0045576)3.69797487
55regulation of vitamin D biosynthetic process (GO:0060556)3.68161827
56myeloid cell development (GO:0061515)3.66034444
57regulation of activation of Janus kinase activity (GO:0010533)3.62871412
58histone H2A acetylation (GO:0043968)3.61888584
59macrophage chemotaxis (GO:0048246)3.59908122
60positive regulation of cell fate commitment (GO:0010455)3.52279099
61T cell costimulation (GO:0031295)3.50769278
62lymphocyte costimulation (GO:0031294)3.46599781
63gas transport (GO:0015669)3.45482502
64C21-steroid hormone biosynthetic process (GO:0006700)3.40986074
65positive regulation of T cell apoptotic process (GO:0070234)3.36379659
66mitochondrial calcium ion homeostasis (GO:0051560)3.31381416
67negative regulation of T cell apoptotic process (GO:0070233)3.31349143
68protoporphyrinogen IX biosynthetic process (GO:0006782)3.26373183
69tetrapyrrole biosynthetic process (GO:0033014)3.26150657
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25561801
71transmission of nerve impulse (GO:0019226)3.24825142
72negative regulation of glial cell proliferation (GO:0060253)3.24236088
73T cell receptor signaling pathway (GO:0050852)3.24199540
74porphyrin-containing compound biosynthetic process (GO:0006779)3.23332405
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22271363
76deoxyribose phosphate biosynthetic process (GO:0046385)3.21617131
772-deoxyribonucleotide biosynthetic process (GO:0009265)3.21617131
78negative thymic T cell selection (GO:0045060)3.13975729
79respiratory burst (GO:0045730)3.05028171
80glycine transport (GO:0015816)3.02094162
81adenine nucleotide transport (GO:0051503)3.02055940
82NIK/NF-kappaB signaling (GO:0038061)3.01406346
83T cell selection (GO:0045058)2.98007552
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96950566
85sequestering of actin monomers (GO:0042989)2.96139356
86regulation of regulatory T cell differentiation (GO:0045589)2.95908978
87negative regulation of cell fate specification (GO:0009996)2.94864146
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93783860
89positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.93506720
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88813848
91purine ribonucleotide transport (GO:0015868)2.85040698
92regulation of vitamin metabolic process (GO:0030656)2.83851876
93positive regulation of hair follicle development (GO:0051798)2.83434348
94positive regulation of hair cycle (GO:0042635)2.83434348
95regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.83370961
96leukocyte degranulation (GO:0043299)2.82469729
97porphyrin-containing compound metabolic process (GO:0006778)2.81559284
98antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81000405
99positive regulation of protein homodimerization activity (GO:0090073)2.79814589
100lysosome localization (GO:0032418)2.79411561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.42591201
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19357686
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48704175
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45555468
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.18512040
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.16100444
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.07979908
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.87594712
9MYB_26560356_Chip-Seq_TH2_Human2.70651688
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.67163263
11GATA1_19941826_ChIP-Seq_K562_Human2.50863670
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40269490
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39512130
14EZH2_22144423_ChIP-Seq_EOC_Human2.37577263
15HTT_18923047_ChIP-ChIP_STHdh_Human2.23453336
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13423851
17UTX_26944678_Chip-Seq_JUKART_Human2.04647404
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99010932
19MAF_26560356_Chip-Seq_TH1_Human1.98968321
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92277963
21KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.90257557
22GATA3_27048872_Chip-Seq_THYMUS_Human1.89515447
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86547655
24RUNX_20019798_ChIP-Seq_JUKART_Human1.84986112
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.84299859
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83860386
27MAF_26560356_Chip-Seq_TH2_Human1.83262534
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83123371
29GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.82811145
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80230863
31VDR_22108803_ChIP-Seq_LS180_Human1.79990487
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79169722
33VDR_23849224_ChIP-Seq_CD4+_Human1.77140500
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69007881
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65427470
36SCL_19346495_ChIP-Seq_HPC-7_Human1.63224178
37CIITA_25753668_ChIP-Seq_RAJI_Human1.62079206
38MYB_26560356_Chip-Seq_TH1_Human1.60009263
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58289035
40BCL6_27268052_Chip-Seq_Bcells_Human1.54431774
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.49881846
42FOXP3_21729870_ChIP-Seq_TREG_Human1.48823304
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46346308
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44786343
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.44513900
46IGF1R_20145208_ChIP-Seq_DFB_Human1.37770302
47ERG_20517297_ChIP-Seq_VCAP_Human1.37575292
48TAF2_19829295_ChIP-Seq_ESCs_Human1.34429265
49GATA2_19941826_ChIP-Seq_K562_Human1.33550892
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31857366
51BCOR_27268052_Chip-Seq_Bcells_Human1.29918297
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28320335
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.26977225
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26425736
55GATA3_26560356_Chip-Seq_TH2_Human1.25589218
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23516394
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23387844
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.23386544
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23353180
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.19252244
61P300_27268052_Chip-Seq_Bcells_Human1.18624555
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18472186
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17918348
64P53_21459846_ChIP-Seq_SAOS-2_Human1.16227232
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13182368
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12370955
67GATA3_26560356_Chip-Seq_TH1_Human1.10732989
68P68_20966046_ChIP-Seq_HELA_Human1.10532859
69CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09677461
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08113000
71PHF8_20622854_ChIP-Seq_HELA_Human1.07364160
72CTCF_21964334_Chip-Seq_Bcells_Human1.07116335
73NANOG_20526341_ChIP-Seq_ESCs_Human1.06798877
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06098124
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05720367
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05715359
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04308395
78LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03795164
79CTCF_20526341_ChIP-Seq_ESCs_Human1.02262383
80ZNF263_19887448_ChIP-Seq_K562_Human1.02167862
81SA1_27219007_Chip-Seq_Bcells_Human1.02144985
82GATA1_22025678_ChIP-Seq_K562_Human1.01762517
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01485133
84EGR1_19032775_ChIP-ChIP_M12_Human0.98413958
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96667156
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96579232
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96327487
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.95778299
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94993008
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94988962
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.94840530
92CTCF_27219007_Chip-Seq_Bcells_Human0.94437649
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94198368
94TP53_22573176_ChIP-Seq_HFKS_Human0.94100008
95RUNX1_22412390_ChIP-Seq_EML_Mouse0.92967589
96GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92610945
97NCOR_22424771_ChIP-Seq_293T_Human0.92492179
98RBPJ_21746931_ChIP-Seq_IB4_Human0.91550560
99GABP_17652178_ChIP-ChIP_JURKAT_Human0.91148481
100ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91141979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition8.34573717
2MP0005671_abnormal_response_to5.41678030
3MP0004147_increased_porphyrin_level4.10556642
4MP0001873_stomach_inflammation3.44351963
5MP0009785_altered_susceptibility_to3.19521691
6MP0003763_abnormal_thymus_physiology3.17159608
7MP0003283_abnormal_digestive_organ2.81880750
8MP0003656_abnormal_erythrocyte_physiolo2.69084839
9MP0008260_abnormal_autophagy2.67711404
10MP0003123_paternal_imprinting2.43160566
11MP0002166_altered_tumor_susceptibility2.40509884
12MP0001835_abnormal_antigen_presentation2.26853432
13MP0009333_abnormal_splenocyte_physiolog2.05585463
14MP0005000_abnormal_immune_tolerance1.98440079
15MP0002933_joint_inflammation1.98127418
16MP0005025_abnormal_response_to1.94714247
17MP0010155_abnormal_intestine_physiology1.91623544
18MP0003787_abnormal_imprinting1.91268374
19MP0004742_abnormal_vestibular_system1.76548267
20MP0002006_tumorigenesis1.73180029
21MP0001485_abnormal_pinna_reflex1.64445487
22MP0005083_abnormal_biliary_tract1.59659300
23MP0000858_altered_metastatic_potential1.59650647
24MP0008875_abnormal_xenobiotic_pharmacok1.57813308
25MP0002420_abnormal_adaptive_immunity1.57314645
26MP0005464_abnormal_platelet_physiology1.55075553
27MP0002405_respiratory_system_inflammati1.54887548
28MP0000685_abnormal_immune_system1.54286468
29MP0000703_abnormal_thymus_morphology1.52835675
30MP0001819_abnormal_immune_cell1.52229850
31MP0002398_abnormal_bone_marrow1.48463846
32MP0002723_abnormal_immune_serum1.44380349
33MP0003448_altered_tumor_morphology1.43664895
34MP0000689_abnormal_spleen_morphology1.42715065
35MP0001845_abnormal_inflammatory_respons1.40541261
36MP0004947_skin_inflammation1.40099154
37MP0002722_abnormal_immune_system1.38246714
38MP0003866_abnormal_defecation1.32693858
39MP0003878_abnormal_ear_physiology1.31500276
40MP0005377_hearing/vestibular/ear_phenot1.31500276
41MP0005645_abnormal_hypothalamus_physiol1.30335213
42MP0000716_abnormal_immune_system1.28233304
43MP0008004_abnormal_stomach_pH1.27869072
44MP0001800_abnormal_humoral_immune1.24124500
45MP0001905_abnormal_dopamine_level1.23409394
46MP0003567_abnormal_fetal_cardiomyocyte1.22243608
47MP0002132_abnormal_respiratory_system1.22206664
48MP0006082_CNS_inflammation1.19997465
49MP0005636_abnormal_mineral_homeostasis1.19233818
50MP0006276_abnormal_autonomic_nervous1.18750848
51MP0001790_abnormal_immune_system1.15565311
52MP0005387_immune_system_phenotype1.15565311
53MP0000490_abnormal_crypts_of1.14334137
54MP0008872_abnormal_physiological_respon1.13835398
55MP0002429_abnormal_blood_cell1.12577430
56MP0008995_early_reproductive_senescence1.09855915
57MP0002452_abnormal_antigen_presenting1.04740103
58MP0002822_catalepsy1.02149518
59MP0001661_extended_life_span0.98108603
60MP0006036_abnormal_mitochondrial_physio0.97149300
61MP0002089_abnormal_postnatal_growth/wei0.94736698
62MP0005551_abnormal_eye_electrophysiolog0.94226466
63MP0005646_abnormal_pituitary_gland0.92445298
64MP0000639_abnormal_adrenal_gland0.91889905
65MP0001764_abnormal_homeostasis0.90036207
66MP0009764_decreased_sensitivity_to0.89220720
67MP0005410_abnormal_fertilization0.88338610
68MP0008469_abnormal_protein_level0.87055771
69MP0009763_increased_sensitivity_to0.84063257
70MP0001765_abnormal_ion_homeostasis0.82653853
71MP0004510_myositis0.81439980
72MP0005166_decreased_susceptibility_to0.81413525
73MP0002019_abnormal_tumor_incidence0.80837701
74MP0004142_abnormal_muscle_tone0.80827217
75MP0000631_abnormal_neuroendocrine_gland0.79495823
76MP0001666_abnormal_nutrient_absorption0.78848028
77MP0002419_abnormal_innate_immunity0.77352608
78MP0008770_decreased_survivor_rate0.77030742
79MP0001919_abnormal_reproductive_system0.77013350
80MP0002136_abnormal_kidney_physiology0.74625310
81MP0001545_abnormal_hematopoietic_system0.73286385
82MP0005397_hematopoietic_system_phenotyp0.73286385
83MP0003943_abnormal_hepatobiliary_system0.72173845
84MP0001663_abnormal_digestive_system0.70987163
85MP0006072_abnormal_retinal_apoptosis0.70696963
86MP0000383_abnormal_hair_follicle0.65247601
87MP0003786_premature_aging0.63475467
88MP0009643_abnormal_urine_homeostasis0.61567462
89MP0001853_heart_inflammation0.61150526
90MP0002148_abnormal_hypersensitivity_rea0.59916690
91MP0001968_abnormal_touch/_nociception0.58991491
92MP0009046_muscle_twitch0.58420350
93MP0002009_preneoplasia0.57374904
94MP0002693_abnormal_pancreas_physiology0.57011265
95MP0005319_abnormal_enzyme/_coenzyme0.56460258
96MP0003938_abnormal_ear_development0.54275183
97MP0003436_decreased_susceptibility_to0.53834020
98MP0002736_abnormal_nociception_after0.52343001
99MP0003638_abnormal_response/metabolism_0.51056880
100MP0008775_abnormal_heart_ventricle0.51039159

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.34484487
2Increased IgM level (HP:0003496)5.32823352
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.25217816
4B lymphocytopenia (HP:0010976)5.02626371
5Aplastic anemia (HP:0001915)4.86801656
6Poikilocytosis (HP:0004447)4.78496376
7Severe combined immunodeficiency (HP:0004430)4.54141138
8Abnormality of T cell number (HP:0011839)4.48039182
9Abnormality of B cell number (HP:0010975)4.40155763
10Hypochromic microcytic anemia (HP:0004840)4.07758108
11Gastrointestinal infarctions (HP:0005244)4.03934893
12IgG deficiency (HP:0004315)4.01945160
13Autoimmune hemolytic anemia (HP:0001890)3.95981002
14Abnormality of binocular vision (HP:0011514)3.95774213
15Diplopia (HP:0000651)3.95774213
16Hypoproteinemia (HP:0003075)3.92338098
17Combined immunodeficiency (HP:0005387)3.86773165
18Thyroiditis (HP:0100646)3.82640693
19Microcytic anemia (HP:0001935)3.81414730
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.65628661
21Reticulocytosis (HP:0001923)3.56189765
22Abnormality of macrophages (HP:0004311)3.09680244
23Encephalitis (HP:0002383)3.02669036
24Hyponatremia (HP:0002902)2.97042636
25Attenuation of retinal blood vessels (HP:0007843)2.95592024
26Abnormality of the prostate (HP:0008775)2.94217182
27Hypoplasia of the thymus (HP:0000778)2.93693146
28Hypoplasia of the uterus (HP:0000013)2.85379638
29Ureteral obstruction (HP:0006000)2.82584895
30Decreased central vision (HP:0007663)2.82187721
31Elevated erythrocyte sedimentation rate (HP:0003565)2.77040291
32Chronic diarrhea (HP:0002028)2.70656078
33Abnormality of reticulocytes (HP:0004312)2.70386039
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69029270
35Ureteral stenosis (HP:0000071)2.61692770
36Obstructive lung disease (HP:0006536)2.57127734
37Chronic obstructive pulmonary disease (HP:0006510)2.57127734
38Constricted visual fields (HP:0001133)2.51943910
39Erythema (HP:0010783)2.50509315
40Agammaglobulinemia (HP:0004432)2.47188921
41Abnormality of sodium homeostasis (HP:0010931)2.43211894
42Abnormal number of erythroid precursors (HP:0012131)2.42822411
43Chronic mucocutaneous candidiasis (HP:0002728)2.42558870
44Recurrent cutaneous fungal infections (HP:0011370)2.42558870
45Abnormality of cells of the erythroid lineage (HP:0012130)2.41743059
46Increased corneal curvature (HP:0100692)2.40033946
47Keratoconus (HP:0000563)2.40033946
48Meningitis (HP:0001287)2.39562571
49Skin rash (HP:0000988)2.37601466
50Pancytopenia (HP:0001876)2.33916285
51Abnormality of T cells (HP:0002843)2.32389638
52Renal Fanconi syndrome (HP:0001994)2.31727843
53Severe visual impairment (HP:0001141)2.31221778
54Abnormal rod and cone electroretinograms (HP:0008323)2.30145383
55Lymphopenia (HP:0001888)2.29549293
56Abnormality of eosinophils (HP:0001879)2.25529011
57Brushfield spots (HP:0001088)2.19770160
58Pendular nystagmus (HP:0012043)2.14829604
59Acute hepatic failure (HP:0006554)2.14761031
60Pustule (HP:0200039)2.11724495
61Hypergammaglobulinemia (HP:0010702)2.11112438
62Tongue fasciculations (HP:0001308)2.10884887
63Gonadal dysgenesis (HP:0000133)2.09886985
64Recurrent otitis media (HP:0000403)2.09348142
65Radial bowing (HP:0002986)2.08305843
66Hypochromic anemia (HP:0001931)2.07965393
67Esophageal neoplasm (HP:0100751)2.07762402
68Neoplasm of head and neck (HP:0012288)2.07762402
69Pulmonary infiltrates (HP:0002113)2.04508118
70Acanthocytosis (HP:0001927)2.04385524
71Female pseudohermaphroditism (HP:0010458)2.00410140
72Lymphoma (HP:0002665)2.00141387
73Chest pain (HP:0100749)1.98759421
74Abnormality of male internal genitalia (HP:0000022)1.97206217
75Aortic dissection (HP:0002647)1.95970676
76Recurrent bronchitis (HP:0002837)1.95446318
77Increased serum ferritin (HP:0003281)1.93108390
78Cholelithiasis (HP:0001081)1.92807664
79Abnormality of the fingertips (HP:0001211)1.92467749
80Bronchitis (HP:0012387)1.91736433
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.91663494
82Muscle fibrillation (HP:0010546)1.89674553
83Pallor (HP:0000980)1.87470260
84Leukocytosis (HP:0001974)1.86515109
85Chronic bronchitis (HP:0004469)1.86340236
86Abnormality of iron homeostasis (HP:0011031)1.86160375
87Abolished electroretinogram (ERG) (HP:0000550)1.85955576
88Glomerulopathy (HP:0100820)1.85776504
89Dyschromatopsia (HP:0007641)1.83660681
90Bowing of the arm (HP:0006488)1.83023562
91Bowed forearm bones (HP:0003956)1.83023562
92Paralysis (HP:0003470)1.81726992
93Mediastinal lymphadenopathy (HP:0100721)1.81478087
94Interstitial pulmonary disease (HP:0006530)1.81327940
95Polyneuropathy (HP:0001271)1.80491843
96Gangrene (HP:0100758)1.79752890
97Male infertility (HP:0003251)1.78180863
98Epistaxis (HP:0000421)1.76462016
99Pigmentary retinal degeneration (HP:0001146)1.76145441
100Cerebral palsy (HP:0100021)1.75560431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.59216355
2TLK16.05391437
3TESK25.72318474
4KDR4.93765400
5TXK2.88670681
6VRK12.80772001
7TNK22.57199313
8TESK12.57125878
9MAP3K112.24029664
10TAOK32.09422257
11CDK81.82675307
12RPS6KA41.79679686
13LIMK11.78141169
14TEC1.76530058
15MAP4K11.72280836
16ZAP701.71220695
17PIM11.66382735
18GRK61.47440050
19ITK1.43412671
20IKBKE1.42725223
21SYK1.30642024
22MST41.22402723
23ADRBK21.22084500
24TRPM71.19706273
25GRK71.19017637
26PASK1.18842240
27PRKD31.17478471
28MAP2K61.16182700
29NEK91.13166767
30RPS6KA51.09374063
31EIF2AK11.07870391
32BCKDK0.91249796
33BTK0.88804870
34PRKCH0.87672854
35CDK40.86608779
36STK160.84712550
37DYRK1B0.84209573
38PRKCQ0.81880837
39MAP3K50.78409048
40TAOK20.76778521
41NME10.76221466
42TYRO30.75958427
43PKN10.70316209
44JAK20.69285293
45LYN0.68803362
46LCK0.67839236
47MAP2K10.63800864
48PAK10.62405033
49CSF1R0.61038925
50BMPR1B0.61001553
51PRKD20.59391028
52GRK10.57526957
53ROCK10.53911749
54MAP3K10.51478779
55AURKA0.51343398
56CAMKK20.51170855
57CSK0.50930074
58LRRK20.50878861
59TBK10.50178584
60FES0.50037529
61FYN0.48571836
62HIPK20.46041651
63MAPK110.44869883
64ERN10.42561840
65BMX0.40276964
66TAOK10.39491274
67TNIK0.39324224
68PRKCA0.38645887
69PLK10.37715511
70DYRK30.32706071
71FRK0.31672021
72VRK20.31552319
73CAMKK10.31512699
74SCYL20.31467541
75MAP2K70.28704192
76MARK30.27827628
77PRKAA20.27390171
78WNK10.27138200
79IKBKB0.25711654
80LMTK20.24665172
81PLK30.24358821
82INSR0.23547045
83PRKACA0.23483407
84PRKCD0.22746208
85INSRR0.22294795
86AKT20.22061129
87ERBB20.20690192
88CSNK2A10.20153134
89PDGFRB0.19470612
90PRKCB0.18823613
91ABL10.15174698
92CSNK1G30.14969803
93RPS6KA60.14828859
94ERBB30.14528765
95OBSCN0.13891723
96TRIM280.13646896
97MYLK0.13380766
98PRKAA10.13363102
99PIM20.13284387
100RPS6KC10.12965296

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.47095796
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.87952850
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.52344551
4Proteasome_Homo sapiens_hsa030503.50042884
5Malaria_Homo sapiens_hsa051443.47052328
6T cell receptor signaling pathway_Homo sapiens_hsa046603.38848796
7Hematopoietic cell lineage_Homo sapiens_hsa046403.25794940
8RNA polymerase_Homo sapiens_hsa030202.95832833
9Oxidative phosphorylation_Homo sapiens_hsa001902.89272841
10Nitrogen metabolism_Homo sapiens_hsa009102.43934374
11Antigen processing and presentation_Homo sapiens_hsa046122.41521945
12Parkinsons disease_Homo sapiens_hsa050122.12017610
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.11706932
14Graft-versus-host disease_Homo sapiens_hsa053321.92303241
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68822705
16Autoimmune thyroid disease_Homo sapiens_hsa053201.58231838
17Shigellosis_Homo sapiens_hsa051311.56395733
18Measles_Homo sapiens_hsa051621.51286293
19Collecting duct acid secretion_Homo sapiens_hsa049661.44193996
20Alzheimers disease_Homo sapiens_hsa050101.33048816
21Ribosome_Homo sapiens_hsa030101.31077951
22Linoleic acid metabolism_Homo sapiens_hsa005911.27601644
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27184243
24One carbon pool by folate_Homo sapiens_hsa006701.25570721
25Allograft rejection_Homo sapiens_hsa053301.21263018
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21158403
27Ether lipid metabolism_Homo sapiens_hsa005651.18699143
28Huntingtons disease_Homo sapiens_hsa050161.17433077
29Cardiac muscle contraction_Homo sapiens_hsa042601.12512211
30Olfactory transduction_Homo sapiens_hsa047401.12401851
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10444198
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07619987
33Phototransduction_Homo sapiens_hsa047441.03240271
34Homologous recombination_Homo sapiens_hsa034401.02340562
35DNA replication_Homo sapiens_hsa030301.01902858
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01630528
37Regulation of autophagy_Homo sapiens_hsa041400.97349019
38Salmonella infection_Homo sapiens_hsa051320.94287483
39Type I diabetes mellitus_Homo sapiens_hsa049400.91200018
40Pyrimidine metabolism_Homo sapiens_hsa002400.82269127
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81253703
42ABC transporters_Homo sapiens_hsa020100.79776116
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79432613
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72722317
45Sphingolipid metabolism_Homo sapiens_hsa006000.72681499
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72204068
47Systemic lupus erythematosus_Homo sapiens_hsa053220.71717176
48Purine metabolism_Homo sapiens_hsa002300.71335506
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69900767
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68764247
51Mineral absorption_Homo sapiens_hsa049780.62681012
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61714413
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61652900
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61066540
55Endocytosis_Homo sapiens_hsa041440.60617930
56Taste transduction_Homo sapiens_hsa047420.59935025
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.58683719
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.56271716
59African trypanosomiasis_Homo sapiens_hsa051430.55084062
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.54119429
61Peroxisome_Homo sapiens_hsa041460.54110117
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52552929
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52466191
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.52342920
65Caffeine metabolism_Homo sapiens_hsa002320.52328007
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.52261646
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52107457
68Rheumatoid arthritis_Homo sapiens_hsa053230.50359967
69Viral myocarditis_Homo sapiens_hsa054160.48277398
70Mismatch repair_Homo sapiens_hsa034300.48218905
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.45723986
72Alcoholism_Homo sapiens_hsa050340.44573322
73Glycerolipid metabolism_Homo sapiens_hsa005610.43385698
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40051218
75Epstein-Barr virus infection_Homo sapiens_hsa051690.35046783
76HTLV-I infection_Homo sapiens_hsa051660.32845238
77Vibrio cholerae infection_Homo sapiens_hsa051100.32362925
78Fanconi anemia pathway_Homo sapiens_hsa034600.31648741
79Fat digestion and absorption_Homo sapiens_hsa049750.28214133
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26858588
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.26678675
82TNF signaling pathway_Homo sapiens_hsa046680.25478388
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22668109
84Metabolic pathways_Homo sapiens_hsa011000.22238528
85Osteoclast differentiation_Homo sapiens_hsa043800.22184774
86Platelet activation_Homo sapiens_hsa046110.21642389
87Apoptosis_Homo sapiens_hsa042100.20738200
88Butanoate metabolism_Homo sapiens_hsa006500.18062101
89Arachidonic acid metabolism_Homo sapiens_hsa005900.17592597
90Ovarian steroidogenesis_Homo sapiens_hsa049130.17301075
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16806436
92Amphetamine addiction_Homo sapiens_hsa050310.16619267
93Ras signaling pathway_Homo sapiens_hsa040140.15862726
94Pancreatic cancer_Homo sapiens_hsa052120.15721060
95MAPK signaling pathway_Homo sapiens_hsa040100.15297459
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13071050
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13011366
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12394206
99Pertussis_Homo sapiens_hsa051330.10695938
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10156196

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