TRBV12-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.20969367
2negative thymic T cell selection (GO:0045060)7.81180481
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.73679601
4negative regulation of cell killing (GO:0031342)7.73679601
5positive regulation of gamma-delta T cell activation (GO:0046645)7.71978639
6regulation of isotype switching to IgG isotypes (GO:0048302)7.43626381
7positive thymic T cell selection (GO:0045059)7.28890960
8positive T cell selection (GO:0043368)6.82237419
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.47818270
10regulation of gamma-delta T cell differentiation (GO:0045586)6.45602361
11thymic T cell selection (GO:0045061)6.29525873
12T cell migration (GO:0072678)6.17981866
13leukocyte aggregation (GO:0070486)6.08971491
14cellular response to interleukin-15 (GO:0071350)6.04158420
15regulation of gamma-delta T cell activation (GO:0046643)5.80056840
16response to interleukin-15 (GO:0070672)5.71069744
17T cell selection (GO:0045058)5.68988741
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.60487109
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.60487109
20interferon-gamma production (GO:0032609)5.55388343
21T cell receptor signaling pathway (GO:0050852)5.39444997
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.20567692
23positive regulation of isotype switching (GO:0045830)5.05582197
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.03188403
25T cell costimulation (GO:0031295)4.90030681
26lymphocyte costimulation (GO:0031294)4.82546101
27positive regulation of alpha-beta T cell proliferation (GO:0046641)4.73205039
28regulation of B cell receptor signaling pathway (GO:0050855)4.60256258
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.58024247
30regulation of alpha-beta T cell proliferation (GO:0046640)4.55885558
31antigen processing and presentation of endogenous antigen (GO:0019883)4.54946427
32antigen receptor-mediated signaling pathway (GO:0050851)4.51950934
33positive regulation of DNA recombination (GO:0045911)4.49154940
34regulation of isotype switching (GO:0045191)4.40613594
35regulation of T cell receptor signaling pathway (GO:0050856)4.38222176
36positive regulation of natural killer cell mediated immunity (GO:0002717)4.34903365
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.34903365
38ribosomal small subunit assembly (GO:0000028)4.17119484
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.16814613
40positive regulation of B cell mediated immunity (GO:0002714)4.07113696
41positive regulation of immunoglobulin mediated immune response (GO:0002891)4.07113696
42regulation of natural killer cell mediated immunity (GO:0002715)4.06256146
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.06256146
44sequestering of actin monomers (GO:0042989)3.97482629
45regulation of T cell tolerance induction (GO:0002664)3.92252844
46mast cell activation (GO:0045576)3.86867724
47regulation of immunoglobulin mediated immune response (GO:0002889)3.84760269
48T cell differentiation (GO:0030217)3.78244041
49regulation of B cell mediated immunity (GO:0002712)3.75733449
50negative regulation of T cell mediated immunity (GO:0002710)3.75095989
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.74183955
52activated T cell proliferation (GO:0050798)3.69743822
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.69530927
54regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.64442523
55regulation of immunoglobulin production (GO:0002637)3.64050967
56positive regulation of interleukin-2 production (GO:0032743)3.64047518
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62802578
58regulation of interleukin-2 biosynthetic process (GO:0045076)3.62161579
59positive regulation of cell killing (GO:0031343)3.60729522
60regulation of response to interferon-gamma (GO:0060330)3.59836952
61positive regulation of lamellipodium assembly (GO:0010592)3.59408267
62positive regulation of immunoglobulin production (GO:0002639)3.57572220
63regulation of cell killing (GO:0031341)3.52176810
64lymphocyte migration (GO:0072676)3.44834438
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.44413734
66leukocyte cell-cell adhesion (GO:0007159)3.43217120
67positive regulation of humoral immune response (GO:0002922)3.41163703
68regulation of T cell mediated cytotoxicity (GO:0001914)3.35216136
69antigen processing and presentation via MHC class Ib (GO:0002475)3.34948941
70regulation of B cell differentiation (GO:0045577)3.31552334
71T cell activation (GO:0042110)3.30323471
72regulation of regulatory T cell differentiation (GO:0045589)3.27104861
73V(D)J recombination (GO:0033151)3.25911618
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.24522799
75positive regulation of tolerance induction (GO:0002645)3.21830264
76alpha-beta T cell differentiation (GO:0046632)3.21801438
77negative regulation of T cell receptor signaling pathway (GO:0050860)3.20627445
78regulation of defense response to virus by virus (GO:0050690)3.20510901
79regulation of interleukin-12 biosynthetic process (GO:0045075)3.18149838
80negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.17809586
81Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15804899
82alpha-beta T cell activation (GO:0046631)3.14422581
83positive regulation of lymphocyte mediated immunity (GO:0002708)3.14278720
84regulation of lymphocyte mediated immunity (GO:0002706)3.11360086
85T cell homeostasis (GO:0043029)3.10448971
86immune response-activating cell surface receptor signaling pathway (GO:0002429)3.09535242
87cellular response to interleukin-4 (GO:0071353)3.08698803
88positive regulation of T cell activation (GO:0050870)3.05194020
89mast cell activation involved in immune response (GO:0002279)3.02383951
90mast cell degranulation (GO:0043303)3.02383951
91regulation of response to tumor cell (GO:0002834)3.02176759
92positive regulation of response to tumor cell (GO:0002836)3.02176759
93positive regulation of immune response to tumor cell (GO:0002839)3.02176759
94regulation of immune response to tumor cell (GO:0002837)3.02176759
95B cell receptor signaling pathway (GO:0050853)3.01305998
96response to type I interferon (GO:0034340)2.95034620
97type I interferon signaling pathway (GO:0060337)2.94182293
98cellular response to type I interferon (GO:0071357)2.94182293
99positive regulation of macrophage differentiation (GO:0045651)2.93925011
100natural killer cell activation (GO:0030101)2.92790862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.83523166
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.30731179
3E2F7_22180533_ChIP-Seq_HELA_Human5.04831080
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87418995
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.44619732
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.31295326
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.30816899
8RUNX_20019798_ChIP-Seq_JUKART_Human3.25658715
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18153450
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05630669
11MYC_22102868_ChIP-Seq_BL_Human2.94687052
12MYB_26560356_Chip-Seq_TH2_Human2.94578502
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.90447147
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79020032
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69674743
16MAF_26560356_Chip-Seq_TH1_Human2.64240277
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60571824
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53770265
19UTX_26944678_Chip-Seq_JUKART_Human2.47693671
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41867536
21MYB_26560356_Chip-Seq_TH1_Human2.40194552
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31247033
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14078217
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.10543299
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.10006173
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97851236
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97251599
28VDR_23849224_ChIP-Seq_CD4+_Human1.92536202
29SPI1_23547873_ChIP-Seq_NB4_Human1.90105578
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.88363513
31VDR_21846776_ChIP-Seq_THP-1_Human1.84088635
32FOXP3_21729870_ChIP-Seq_TREG_Human1.83147150
33MAF_26560356_Chip-Seq_TH2_Human1.80234007
34SCL_19346495_ChIP-Seq_HPC-7_Human1.74930141
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.71129040
36GATA3_27048872_Chip-Seq_THYMUS_Human1.67849581
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.65763533
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.61135971
39CIITA_25753668_ChIP-Seq_RAJI_Human1.60332250
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.60258080
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60232237
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59583175
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.59031319
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.57007277
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51720494
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51568823
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48681294
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47425693
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41332147
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40598736
51VDR_24763502_ChIP-Seq_THP-1_Human1.39950463
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39489697
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38171978
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37582980
55TCF7_22412390_ChIP-Seq_EML_Mouse1.37233735
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35994661
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35069478
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33045051
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31720314
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27058955
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26141306
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.25271950
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22964402
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22833295
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22043676
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18620067
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.17786414
68XRN2_22483619_ChIP-Seq_HELA_Human1.16330268
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15973462
70ELK1_19687146_ChIP-ChIP_HELA_Human1.13472256
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13353829
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12002344
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09194101
74SPI1_23127762_ChIP-Seq_K562_Human1.08839022
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06248125
76GATA3_26560356_Chip-Seq_TH2_Human1.05417945
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04150192
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02415976
79GABP_19822575_ChIP-Seq_HepG2_Human1.01696475
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00185013
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99045896
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98586883
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98558628
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97181146
85KDM2B_26808549_Chip-Seq_DND41_Human0.96860661
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94169752
87NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92487875
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92397610
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91434888
90PU_27001747_Chip-Seq_BMDM_Mouse0.90923012
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89961258
92DCP1A_22483619_ChIP-Seq_HELA_Human0.89720668
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89511105
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88089679
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.88030163
96CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86853844
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85922175
98KDM5A_27292631_Chip-Seq_BREAST_Human0.82462350
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82034900
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81698507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.06765014
2MP0005671_abnormal_response_to5.50211861
3MP0000685_abnormal_immune_system3.57782289
4MP0001835_abnormal_antigen_presentation3.41409940
5MP0009785_altered_susceptibility_to3.33736506
6MP0002166_altered_tumor_susceptibility3.20115319
7MP0009333_abnormal_splenocyte_physiolog3.10218631
8MP0001800_abnormal_humoral_immune2.98715277
9MP0002398_abnormal_bone_marrow2.96526750
10MP0003724_increased_susceptibility_to2.83222554
11MP0002405_respiratory_system_inflammati2.82820344
12MP0005000_abnormal_immune_tolerance2.79821309
13MP0002420_abnormal_adaptive_immunity2.79569703
14MP0000703_abnormal_thymus_morphology2.79134183
15MP0006082_CNS_inflammation2.78577033
16MP0001819_abnormal_immune_cell2.74264327
17MP0002723_abnormal_immune_serum2.73468417
18MP0002006_tumorigenesis2.72549518
19MP0001790_abnormal_immune_system2.59405107
20MP0005387_immune_system_phenotype2.59405107
21MP0005025_abnormal_response_to2.56879749
22MP0000716_abnormal_immune_system2.50295170
23MP0002396_abnormal_hematopoietic_system2.44724595
24MP0002452_abnormal_antigen_presenting2.42716793
25MP0002722_abnormal_immune_system2.40837268
26MP0000689_abnormal_spleen_morphology2.30369979
27MP0001873_stomach_inflammation2.19694885
28MP0003436_decreased_susceptibility_to2.10992336
29MP0002429_abnormal_blood_cell2.08235170
30MP0003866_abnormal_defecation2.04279471
31MP0010155_abnormal_intestine_physiology1.96563398
32MP0002933_joint_inflammation1.93688883
33MP0002148_abnormal_hypersensitivity_rea1.92434489
34MP0004947_skin_inflammation1.91752493
35MP0002132_abnormal_respiratory_system1.70890560
36MP0004381_abnormal_hair_follicle1.70739244
37MP0002419_abnormal_innate_immunity1.69727794
38MP0000858_altered_metastatic_potential1.65270026
39MP0005464_abnormal_platelet_physiology1.65076288
40MP0001853_heart_inflammation1.57338647
41MP0003693_abnormal_embryo_hatching1.56674319
42MP0001845_abnormal_inflammatory_respons1.56347089
43MP0008057_abnormal_DNA_replication1.43227250
44MP0002019_abnormal_tumor_incidence1.42637348
45MP0005075_abnormal_melanosome_morpholog1.42189260
46MP0010094_abnormal_chromosome_stability1.36786939
47MP0003448_altered_tumor_morphology1.34006829
48MP0003300_gastrointestinal_ulcer1.33738988
49MP0003077_abnormal_cell_cycle1.29722463
50MP0004808_abnormal_hematopoietic_stem1.21199141
51MP0010352_gastrointestinal_tract_polyps1.18264897
52MP0008469_abnormal_protein_level1.16667829
53MP0004957_abnormal_blastocyst_morpholog1.15916326
54MP0000465_gastrointestinal_hemorrhage1.15075476
55MP0000490_abnormal_crypts_of1.11240235
56MP0008058_abnormal_DNA_repair1.09941371
57MP0003045_fibrosis1.09372766
58MP0008007_abnormal_cellular_replicative1.07627318
59MP0005310_abnormal_salivary_gland1.05426575
60MP0001533_abnormal_skeleton_physiology1.02735357
61MP0004510_myositis0.97855347
62MP0001545_abnormal_hematopoietic_system0.92918058
63MP0005397_hematopoietic_system_phenotyp0.92918058
64MP0003111_abnormal_nucleus_morphology0.92717140
65MP0001851_eye_inflammation0.86977175
66MP0005174_abnormal_tail_pigmentation0.85949651
67MP0001243_abnormal_dermal_layer0.81144278
68MP0002998_abnormal_bone_remodeling0.80856334
69MP0002009_preneoplasia0.75895286
70MP0002095_abnormal_skin_pigmentation0.72259445
71MP0009763_increased_sensitivity_to0.70277081
72MP0000015_abnormal_ear_pigmentation0.65936463
73MP0005166_decreased_susceptibility_to0.65669738
74MP0009765_abnormal_xenobiotic_induced0.64890254
75MP0005023_abnormal_wound_healing0.63737736
76MP0009764_decreased_sensitivity_to0.61897914
77MP0000477_abnormal_intestine_morphology0.59761352
78MP0000313_abnormal_cell_death0.57529319
79MP0000609_abnormal_liver_physiology0.48759998
80MP0003795_abnormal_bone_structure0.48599077
81MP0002136_abnormal_kidney_physiology0.47704742
82MP0002693_abnormal_pancreas_physiology0.46565806
83MP0001191_abnormal_skin_condition0.45485925
84MP0008873_increased_physiological_sensi0.43616958
85MP0003786_premature_aging0.43321262
86MP0000343_altered_response_to0.43162253
87MP0001348_abnormal_lacrimal_gland0.42924676
88MP0008569_lethality_at_weaning0.42281853
89MP0008877_abnormal_DNA_methylation0.41925894
90MP0003303_peritoneal_inflammation0.40780313
91MP0002083_premature_death0.40475407
92MP0002138_abnormal_hepatobiliary_system0.37752795
93MP0008770_decreased_survivor_rate0.37672086
94MP0003943_abnormal_hepatobiliary_system0.37518151
95MP0000350_abnormal_cell_proliferation0.36545994
96MP0003221_abnormal_cardiomyocyte_apopto0.36131006
97MP0005409_darkened_coat_color0.35923561
98MP0000604_amyloidosis0.35775382
99MP0006054_spinal_hemorrhage0.35156024
100MP0002822_catalepsy0.34913355

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.68968320
2Abnormality of T cell number (HP:0011839)8.36801833
3Severe combined immunodeficiency (HP:0004430)8.01184939
4Combined immunodeficiency (HP:0005387)7.32216525
5Abnormality of T cells (HP:0002843)5.93469921
6IgG deficiency (HP:0004315)5.73656357
7Increased IgM level (HP:0003496)5.24318626
8Elevated erythrocyte sedimentation rate (HP:0003565)5.23829881
9Thyroiditis (HP:0100646)5.20688521
10Stomatitis (HP:0010280)5.20660211
11Hypoplasia of the thymus (HP:0000778)5.12794565
12Recurrent bronchitis (HP:0002837)4.89652300
13Panhypogammaglobulinemia (HP:0003139)4.89168771
14Recurrent fungal infections (HP:0002841)4.58839019
15Abnormality of eosinophils (HP:0001879)4.32257940
16Recurrent cutaneous fungal infections (HP:0011370)4.29707588
17Chronic mucocutaneous candidiasis (HP:0002728)4.29707588
18IgM deficiency (HP:0002850)4.25965204
19Eczematoid dermatitis (HP:0000976)4.02000444
20Chronic diarrhea (HP:0002028)3.96909102
21Chronic otitis media (HP:0000389)3.93105405
22Recurrent viral infections (HP:0004429)3.90740268
23B lymphocytopenia (HP:0010976)3.82312280
24Abnormality of B cell number (HP:0010975)3.82312280
25Nasal polyposis (HP:0100582)3.74057867
26Autoimmune hemolytic anemia (HP:0001890)3.64363801
27Leukocytosis (HP:0001974)3.62565615
28Abnormality of T cell physiology (HP:0011840)3.55232757
29Myositis (HP:0100614)3.36736169
30Eosinophilia (HP:0001880)3.18712975
31IgA deficiency (HP:0002720)3.13520537
32Lymphopenia (HP:0001888)3.08917942
33Abnormality of the nasal mucosa (HP:0000433)3.04576402
34Joint swelling (HP:0001386)3.03305409
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.02228108
36Abnormality of the fingertips (HP:0001211)2.97323914
37Lymphoma (HP:0002665)2.92783247
38Hypergammaglobulinemia (HP:0010702)2.87009107
39Optic neuritis (HP:0100653)2.81354173
40Retrobulbar optic neuritis (HP:0100654)2.81354173
41Granulocytopenia (HP:0001913)2.80565696
42Gastrointestinal infarctions (HP:0005244)2.76664474
43Pustule (HP:0200039)2.75843758
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.71540505
45Bronchitis (HP:0012387)2.67757827
46Meningitis (HP:0001287)2.63082715
47Encephalitis (HP:0002383)2.57829861
48Hemoptysis (HP:0002105)2.53923466
49Aplastic anemia (HP:0001915)2.49987374
50Recurrent skin infections (HP:0001581)2.47242208
51Agammaglobulinemia (HP:0004432)2.42708686
52Aplasia/Hypoplasia of the thymus (HP:0010515)2.40727865
53Recurrent abscess formation (HP:0002722)2.34956568
54Orchitis (HP:0100796)2.34596520
55Petechiae (HP:0000967)2.31144272
56Vasculitis (HP:0002633)2.29864831
57Autoimmune thrombocytopenia (HP:0001973)2.29153774
58Prolonged bleeding time (HP:0003010)2.28328665
59Abnormality of the prostate (HP:0008775)2.26878202
60Thrombocytosis (HP:0001894)2.26219917
61Recurrent sinusitis (HP:0011108)2.24261143
62Hypoproteinemia (HP:0003075)2.20145930
63Keratoconjunctivitis sicca (HP:0001097)2.18929301
64Basal cell carcinoma (HP:0002671)2.17657633
65Pulmonary infiltrates (HP:0002113)2.17462485
66Reduced subcutaneous adipose tissue (HP:0003758)2.17141185
67Mediastinal lymphadenopathy (HP:0100721)2.13152841
68Obstructive lung disease (HP:0006536)2.08511475
69Chronic obstructive pulmonary disease (HP:0006510)2.08511475
70Abnormal number of erythroid precursors (HP:0012131)2.07949374
71Epistaxis (HP:0000421)2.07860601
72Hepatitis (HP:0012115)2.06635638
73Abnormal platelet volume (HP:0011876)2.05969783
74Amaurosis fugax (HP:0100576)2.03732904
75Abnormality of cells of the erythroid lineage (HP:0012130)1.97824629
76Keratoconjunctivitis (HP:0001096)1.95935389
77Gastrointestinal inflammation (HP:0004386)1.94969066
78Pancytopenia (HP:0001876)1.93405852
79Inflammation of the large intestine (HP:0002037)1.93269559
80Type 2 muscle fiber atrophy (HP:0003554)1.91562104
81Cellular immunodeficiency (HP:0005374)1.91255890
82Microcytic anemia (HP:0001935)1.91224861
83Muscle fiber atrophy (HP:0100295)1.90375932
84Cheilitis (HP:0100825)1.89843979
85Premature graying of hair (HP:0002216)1.85853870
86Chronic sinusitis (HP:0011109)1.85722055
87Recurrent otitis media (HP:0000403)1.84880515
88Spontaneous hematomas (HP:0007420)1.79788311
89Abnormality of the thymus (HP:0000777)1.79306842
90Gangrene (HP:0100758)1.78811724
91Purpura (HP:0000979)1.76629228
92Pulmonary fibrosis (HP:0002206)1.76437101
93Reticulocytopenia (HP:0001896)1.75538804
94Gingivitis (HP:0000230)1.73992498
95Arterial thrombosis (HP:0004420)1.73652834
96Renal cortical cysts (HP:0000803)1.71704122
97Pulmonary embolism (HP:0002204)1.69741300
98Poikiloderma (HP:0001029)1.67719209
99Amyotrophic lateral sclerosis (HP:0007354)1.67467820
100Anorexia (HP:0002039)1.66514677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.07008486
2MAP4K15.54250308
3ZAP703.82837682
4TESK23.38980691
5ITK3.24492218
6KDR3.09344526
7IKBKE2.90073245
8JAK32.87046613
9FGFR42.53826622
10TYK22.18565635
11NLK2.17792163
12MAP3K122.17686647
13BUB12.11675777
14LCK1.96644989
15TBK11.84905747
16BTK1.83359969
17TEC1.81903860
18NME21.79746260
19STK101.77292039
20GRK61.71380554
21MST41.69751884
22JAK11.61404624
23CSK1.60599509
24IRAK41.54673374
25FGFR31.51047932
26MAP3K141.39651278
27BLK1.38588030
28SYK1.37107550
29KIT1.31435884
30TESK11.25231086
31HCK1.23354553
32TNK21.18029098
33TSSK61.17019020
34EEF2K1.08525708
35PRKCQ1.00298489
36LYN0.98470156
37STK160.96061226
38LRRK20.92829931
39EIF2AK10.92466249
40PASK0.87376457
41PRKCH0.85969335
42CLK10.85808293
43TLK10.82825654
44IKBKB0.79648794
45MAP3K110.79526568
46CDC70.77334473
47MAP3K100.64924598
48EIF2AK30.63713664
49JAK20.62717921
50MAPK110.61592153
51PIM10.58394964
52STK40.55074086
53MAP3K70.54984240
54CSF1R0.54742393
55ILK0.51609483
56RPS6KA40.49631590
57ACVR1B0.47949357
58TGFBR20.47453072
59MAP2K60.46913068
60LIMK10.45840914
61CHUK0.44798176
62SIK30.44210559
63FYN0.43432331
64DAPK10.42260781
65TGFBR10.42212035
66FGFR10.42056462
67INSR0.41098491
68MELK0.40102951
69PKN20.38927234
70RPS6KB20.38666225
71CDK40.38638861
72NEK20.38089594
73PIM20.37949217
74FES0.36795113
75ATR0.35520878
76SRPK10.35513701
77VRK10.35299227
78MYLK0.35030019
79NUAK10.35003634
80PDGFRB0.34059500
81IRAK20.33256645
82IGF1R0.30402951
83HIPK20.30241265
84MARK30.28179151
85DAPK30.27852940
86AURKB0.27518486
87PDK10.23840293
88WEE10.23483448
89SIK20.23467421
90MAP2K30.22966975
91MARK20.22322409
92IRAK10.22018883
93MAPK30.19409924
94PRKCD0.19188442
95CDK70.18980422
96RPS6KA50.18545524
97CDK90.18427421
98SRC0.18360834
99ADRBK20.18234323
100MAPK70.17025166

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.32353362
2Graft-versus-host disease_Homo sapiens_hsa053324.03989779
3T cell receptor signaling pathway_Homo sapiens_hsa046603.64538127
4Allograft rejection_Homo sapiens_hsa053303.36425594
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.33841003
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.84886921
7Antigen processing and presentation_Homo sapiens_hsa046122.77486354
8Measles_Homo sapiens_hsa051622.68336040
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.60621334
10DNA replication_Homo sapiens_hsa030302.20877443
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.16647089
12Autoimmune thyroid disease_Homo sapiens_hsa053202.15816571
13Ribosome_Homo sapiens_hsa030102.12429997
14Hematopoietic cell lineage_Homo sapiens_hsa046402.11094589
15Viral myocarditis_Homo sapiens_hsa054162.06840876
16Mismatch repair_Homo sapiens_hsa034301.94311320
17Non-homologous end-joining_Homo sapiens_hsa034501.74336965
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71999487
19Proteasome_Homo sapiens_hsa030501.59554835
20Base excision repair_Homo sapiens_hsa034101.55652644
21Herpes simplex infection_Homo sapiens_hsa051681.50408185
22Type I diabetes mellitus_Homo sapiens_hsa049401.49954840
23Leishmaniasis_Homo sapiens_hsa051401.47248060
24Spliceosome_Homo sapiens_hsa030401.42273457
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.38469477
26Homologous recombination_Homo sapiens_hsa034401.32846193
27Nucleotide excision repair_Homo sapiens_hsa034201.30553448
28Osteoclast differentiation_Homo sapiens_hsa043801.26380733
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25306037
30B cell receptor signaling pathway_Homo sapiens_hsa046621.21579700
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19013453
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15509223
33Asthma_Homo sapiens_hsa053101.13624050
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11487878
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11390087
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04861034
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.03501057
38HTLV-I infection_Homo sapiens_hsa051660.99516307
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97766677
40Chemokine signaling pathway_Homo sapiens_hsa040620.96935112
41RNA degradation_Homo sapiens_hsa030180.96724412
42Hepatitis B_Homo sapiens_hsa051610.96597103
43Shigellosis_Homo sapiens_hsa051310.92370438
44Toxoplasmosis_Homo sapiens_hsa051450.91504309
45Acute myeloid leukemia_Homo sapiens_hsa052210.90882728
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89032296
47Colorectal cancer_Homo sapiens_hsa052100.88736689
48Influenza A_Homo sapiens_hsa051640.79670328
49Pancreatic cancer_Homo sapiens_hsa052120.77990433
50Cell cycle_Homo sapiens_hsa041100.77211115
51p53 signaling pathway_Homo sapiens_hsa041150.76728624
52Malaria_Homo sapiens_hsa051440.76235532
53Pyrimidine metabolism_Homo sapiens_hsa002400.75906196
54RNA polymerase_Homo sapiens_hsa030200.71705257
55Epstein-Barr virus infection_Homo sapiens_hsa051690.71433446
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70196880
57Apoptosis_Homo sapiens_hsa042100.69290278
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68217615
59Viral carcinogenesis_Homo sapiens_hsa052030.67121214
60RNA transport_Homo sapiens_hsa030130.65848917
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64498924
62Platelet activation_Homo sapiens_hsa046110.61788561
63Legionellosis_Homo sapiens_hsa051340.61095979
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60268374
65VEGF signaling pathway_Homo sapiens_hsa043700.56960493
66mRNA surveillance pathway_Homo sapiens_hsa030150.54403205
67Pentose phosphate pathway_Homo sapiens_hsa000300.53470650
68Protein export_Homo sapiens_hsa030600.51360733
69Basal transcription factors_Homo sapiens_hsa030220.49912040
70Systemic lupus erythematosus_Homo sapiens_hsa053220.48230006
71Chronic myeloid leukemia_Homo sapiens_hsa052200.48055617
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46684834
73Salmonella infection_Homo sapiens_hsa051320.45243882
74Thyroid cancer_Homo sapiens_hsa052160.44615130
75Hepatitis C_Homo sapiens_hsa051600.44415881
76Fanconi anemia pathway_Homo sapiens_hsa034600.44019505
77TNF signaling pathway_Homo sapiens_hsa046680.43957165
78One carbon pool by folate_Homo sapiens_hsa006700.33528441
79Caffeine metabolism_Homo sapiens_hsa002320.32654996
80Tuberculosis_Homo sapiens_hsa051520.30403793
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29007637
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26823833
83Prolactin signaling pathway_Homo sapiens_hsa049170.25760788
84Endocytosis_Homo sapiens_hsa041440.25232882
85Pertussis_Homo sapiens_hsa051330.24667769
86Rheumatoid arthritis_Homo sapiens_hsa053230.23458739
87Staphylococcus aureus infection_Homo sapiens_hsa051500.23380040
88Purine metabolism_Homo sapiens_hsa002300.20912399
89Small cell lung cancer_Homo sapiens_hsa052220.20726031
90Notch signaling pathway_Homo sapiens_hsa043300.16339037
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.15063844
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.12808200
93Adherens junction_Homo sapiens_hsa045200.12673905
94Non-small cell lung cancer_Homo sapiens_hsa052230.11865183
95Rap1 signaling pathway_Homo sapiens_hsa040150.11172459
96Other glycan degradation_Homo sapiens_hsa005110.10686849
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10414277
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.10174708
99Pathways in cancer_Homo sapiens_hsa052000.06589930
100Sulfur relay system_Homo sapiens_hsa041220.06261044

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