TRBJ2-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)9.05175076
2cytidine deamination (GO:0009972)9.05175076
3cytidine metabolic process (GO:0046087)9.05175076
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.84169882
5DNA deamination (GO:0045006)8.30086438
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.85495391
7Arp2/3 complex-mediated actin nucleation (GO:0034314)6.88359006
8regulation of activation of Janus kinase activity (GO:0010533)6.78937699
9actin nucleation (GO:0045010)6.07170980
10negative T cell selection (GO:0043383)5.10786801
11regulation of B cell receptor signaling pathway (GO:0050855)4.95929370
12T cell migration (GO:0072678)4.84909751
13positive T cell selection (GO:0043368)4.62537066
14eosinophil chemotaxis (GO:0048245)4.59501200
15negative regulation of stress fiber assembly (GO:0051497)4.48530706
16pyrimidine nucleoside catabolic process (GO:0046135)4.34333356
17negative regulation by host of viral transcription (GO:0043922)4.32854690
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.30506314
19negative regulation of T cell apoptotic process (GO:0070233)4.29400912
20positive regulation of B cell differentiation (GO:0045579)4.25804025
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24034575
22positive regulation of calcium-mediated signaling (GO:0050850)4.21533107
23eosinophil migration (GO:0072677)4.17047637
24sequestering of actin monomers (GO:0042989)4.16542124
25negative regulation of viral genome replication (GO:0045071)4.12172598
26negative regulation of B cell proliferation (GO:0030889)4.08831877
27positive regulation of monocyte chemotaxis (GO:0090026)4.05481713
28positive thymic T cell selection (GO:0045059)4.05409315
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.04299672
30cellular response to interleukin-15 (GO:0071350)3.95034451
31regulation of T cell tolerance induction (GO:0002664)3.90666177
32cytolysis (GO:0019835)3.90097166
33positive regulation of natural killer cell differentiation (GO:0032825)3.89140000
34positive regulation of gamma-delta T cell activation (GO:0046645)3.87851315
35positive regulation of tolerance induction (GO:0002645)3.87178346
36metallo-sulfur cluster assembly (GO:0031163)3.85342497
37iron-sulfur cluster assembly (GO:0016226)3.85342497
38T cell selection (GO:0045058)3.84630131
39monocyte chemotaxis (GO:0002548)3.82533020
40positive regulation of interleukin-8 secretion (GO:2000484)3.78481739
41response to interferon-beta (GO:0035456)3.77304363
42antigen processing and presentation via MHC class Ib (GO:0002475)3.68505394
43thymic T cell selection (GO:0045061)3.67891355
44regulation of B cell differentiation (GO:0045577)3.67313382
45regulation of natural killer cell differentiation (GO:0032823)3.65399868
46regulation of T cell receptor signaling pathway (GO:0050856)3.63349462
47T cell costimulation (GO:0031295)3.62307281
48T cell receptor signaling pathway (GO:0050852)3.61748338
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61292357
50negative thymic T cell selection (GO:0045060)3.58648219
51macrophage chemotaxis (GO:0048246)3.58084337
52lymphocyte costimulation (GO:0031294)3.57940019
53regulation of chronic inflammatory response (GO:0002676)3.56982250
54negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.52195232
55positive regulation of interleukin-4 production (GO:0032753)3.47251158
56negative regulation of actin filament bundle assembly (GO:0032232)3.45448252
57positive regulation of natural killer cell mediated immunity (GO:0002717)3.45003678
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.43277481
59regulation of gamma-delta T cell differentiation (GO:0045586)3.41455414
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.40586678
61antigen receptor-mediated signaling pathway (GO:0050851)3.40150548
62negative regulation of phagocytosis (GO:0050765)3.38699835
63negative regulation of oxidoreductase activity (GO:0051354)3.38348260
64positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.38329659
65negative regulation of lymphocyte apoptotic process (GO:0070229)3.38122657
66regulation of mitochondrial translation (GO:0070129)3.37408717
67DNA demethylation (GO:0080111)3.36247759
68signal complex assembly (GO:0007172)3.35464410
69regulation of regulatory T cell differentiation (GO:0045589)3.33491079
70regulation of tolerance induction (GO:0002643)3.30454840
71negative regulation of mast cell activation (GO:0033004)3.27268451
72pyrimidine nucleotide catabolic process (GO:0006244)3.26975066
73dendritic cell chemotaxis (GO:0002407)3.26782841
74negative regulation of nitric-oxide synthase activity (GO:0051001)3.25833185
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21365484
76positive regulation of defense response to virus by host (GO:0002230)3.19404299
77regulation of calcium-mediated signaling (GO:0050848)3.14203687
78immunoglobulin mediated immune response (GO:0016064)3.14046117
79regulation of defense response to virus by virus (GO:0050690)3.13193517
80B cell receptor signaling pathway (GO:0050853)3.11640270
81chemokine-mediated signaling pathway (GO:0070098)3.10886993
82regulation of mononuclear cell migration (GO:0071675)3.10111407
83regulation of interleukin-2 biosynthetic process (GO:0045076)3.09662400
84positive regulation of cell killing (GO:0031343)3.07491699
85positive regulation of T cell cytokine production (GO:0002726)3.07018171
86peptidyl-arginine omega-N-methylation (GO:0035247)3.05072018
87response to interleukin-15 (GO:0070672)3.02814228
88regulation of chemokine-mediated signaling pathway (GO:0070099)3.01430498
89positive regulation of T cell apoptotic process (GO:0070234)2.99313037
90dendritic cell migration (GO:0036336)2.99305408
91positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.98676362
92regulation of viral genome replication (GO:0045069)2.98251770
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97836015
94regulation of macrophage chemotaxis (GO:0010758)2.95887575
95mast cell activation (GO:0045576)2.92566835
96lymphocyte migration (GO:0072676)2.92317206
97DNA dealkylation (GO:0035510)2.91831311
98regulation of natural killer cell mediated immunity (GO:0002715)2.90428872
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90428872
100ubiquinone biosynthetic process (GO:0006744)2.88845120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.88761668
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.01485552
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.09986168
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.66235191
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53731826
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16306860
7MYB_26560356_Chip-Seq_TH2_Human3.02119896
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60829089
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60377977
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59750327
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47706483
12RUNX_20019798_ChIP-Seq_JUKART_Human2.43635713
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31404121
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.30090995
15UTX_26944678_Chip-Seq_JUKART_Human2.20900947
16GATA3_27048872_Chip-Seq_THYMUS_Human2.20125781
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17945892
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17326000
19CIITA_25753668_ChIP-Seq_RAJI_Human2.09904805
20MYB_26560356_Chip-Seq_TH1_Human2.07644038
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01713732
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92824084
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90692955
24EZH2_22144423_ChIP-Seq_EOC_Human1.87664292
25GATA3_26560356_Chip-Seq_TH2_Human1.85364546
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.74844298
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66557978
28MAF_26560356_Chip-Seq_TH2_Human1.64473664
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59239313
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53520989
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.51825624
32MAF_26560356_Chip-Seq_TH1_Human1.51768583
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50234112
34SPI1_23547873_ChIP-Seq_NB4_Human1.48297021
35VDR_23849224_ChIP-Seq_CD4+_Human1.45637751
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45541241
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45323685
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43952467
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41969139
40VDR_22108803_ChIP-Seq_LS180_Human1.39940835
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.34434055
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33503895
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.29641774
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29348065
45NANOG_20526341_ChIP-Seq_ESCs_Human1.29216148
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27841043
47BCL6_27268052_Chip-Seq_Bcells_Human1.26321165
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24891147
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.23790175
50HTT_18923047_ChIP-ChIP_STHdh_Human1.22251166
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21739897
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.21536876
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21361170
54EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.21154311
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20774045
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18493445
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18382786
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18143972
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17111263
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.16541197
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16085880
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.14370585
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13642068
64ERG_20517297_ChIP-Seq_VCAP_Human1.12751065
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11474679
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08297446
67AR_20517297_ChIP-Seq_VCAP_Human1.07528086
68CTCF_20526341_ChIP-Seq_ESCs_Human1.05361417
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04786663
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04647031
71ELK1_19687146_ChIP-ChIP_HELA_Human1.04544779
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03252888
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02960210
74SA1_27219007_Chip-Seq_Bcells_Human1.02416587
75TP53_22573176_ChIP-Seq_HFKS_Human1.02244760
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01293561
77TAF2_19829295_ChIP-Seq_ESCs_Human1.01289941
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.01124287
79P300_27268052_Chip-Seq_Bcells_Human1.00115050
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98919052
81FOXP3_21729870_ChIP-Seq_TREG_Human0.97872417
82NCOR_22424771_ChIP-Seq_293T_Human0.96086631
83RUNX1_22412390_ChIP-Seq_EML_Mouse0.95255767
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91232191
85BCOR_27268052_Chip-Seq_Bcells_Human0.90195908
86ERA_21632823_ChIP-Seq_H3396_Human0.89717716
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88980971
88GATA3_26560356_Chip-Seq_TH1_Human0.88636684
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88336409
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85030959
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84978106
92TAF15_26573619_Chip-Seq_HEK293_Human0.84863750
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.84663563
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81679379
95SPI1_20517297_ChIP-Seq_HL60_Human0.80278140
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80167776
97P68_20966046_ChIP-Seq_HELA_Human0.78518340
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77836585
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.77455537
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77455537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.56541599
2MP0003763_abnormal_thymus_physiology3.78728396
3MP0001835_abnormal_antigen_presentation3.36228746
4MP0009785_altered_susceptibility_to3.35038272
5MP0008057_abnormal_DNA_replication3.08560135
6MP0001800_abnormal_humoral_immune2.78771022
7MP0005000_abnormal_immune_tolerance2.67497682
8MP0005025_abnormal_response_to2.64987447
9MP0000685_abnormal_immune_system2.62136425
10MP0002166_altered_tumor_susceptibility2.61006346
11MP0002653_abnormal_ependyma_morphology2.55238941
12MP0001790_abnormal_immune_system2.47088096
13MP0005387_immune_system_phenotype2.47088096
14MP0004147_increased_porphyrin_level2.42599825
15MP0002420_abnormal_adaptive_immunity2.42051003
16MP0002148_abnormal_hypersensitivity_rea2.38955014
17MP0001819_abnormal_immune_cell2.36409991
18MP0002723_abnormal_immune_serum2.35751564
19MP0001873_stomach_inflammation2.20979480
20MP0009333_abnormal_splenocyte_physiolog2.19601559
21MP0002452_abnormal_antigen_presenting2.03157456
22MP0000569_abnormal_digit_pigmentation2.00733234
23MP0002405_respiratory_system_inflammati1.94514893
24MP0002006_tumorigenesis1.94002026
25MP0002398_abnormal_bone_marrow1.93699208
26MP0000716_abnormal_immune_system1.87383643
27MP0003880_abnormal_central_pattern1.83883959
28MP0003866_abnormal_defecation1.83117169
29MP0001853_heart_inflammation1.82129051
30MP0006082_CNS_inflammation1.77948349
31MP0010155_abnormal_intestine_physiology1.62545247
32MP0002722_abnormal_immune_system1.61973982
33MP0000689_abnormal_spleen_morphology1.55531768
34MP0001845_abnormal_inflammatory_respons1.53819336
35MP0000703_abnormal_thymus_morphology1.53170796
36MP0002419_abnormal_innate_immunity1.49681145
37MP0002877_abnormal_melanocyte_morpholog1.48632055
38MP0003191_abnormal_cellular_cholesterol1.46997941
39MP0002138_abnormal_hepatobiliary_system1.46148289
40MP0002429_abnormal_blood_cell1.43856404
41MP0003045_fibrosis1.38668060
42MP0003646_muscle_fatigue1.38577757
43MP0009840_abnormal_foam_cell1.37160207
44MP0001905_abnormal_dopamine_level1.32583777
45MP0005075_abnormal_melanosome_morpholog1.31032566
46MP0005464_abnormal_platelet_physiology1.30664622
47MP0004134_abnormal_chest_morphology1.30005929
48MP0000372_irregular_coat_pigmentation1.29581727
49MP0002933_joint_inflammation1.24518153
50MP0002102_abnormal_ear_morphology1.21071156
51MP0000858_altered_metastatic_potential1.19728745
52MP0005645_abnormal_hypothalamus_physiol1.17429737
53MP0008469_abnormal_protein_level1.14351505
54MP0003806_abnormal_nucleotide_metabolis1.13917003
55MP0008058_abnormal_DNA_repair1.13783728
56MP0002095_abnormal_skin_pigmentation1.10573863
57MP0003786_premature_aging1.09932795
58MP0003448_altered_tumor_morphology1.06088812
59MP0003436_decreased_susceptibility_to1.05764086
60MP0002132_abnormal_respiratory_system1.04935254
61MP0009643_abnormal_urine_homeostasis1.04497233
62MP0002019_abnormal_tumor_incidence1.00564730
63MP0002693_abnormal_pancreas_physiology0.99524324
64MP0009764_decreased_sensitivity_to0.99071136
65MP0009379_abnormal_foot_pigmentation0.98666696
66MP0003183_abnormal_peptide_metabolism0.93973968
67MP0009763_increased_sensitivity_to0.92824768
68MP0004947_skin_inflammation0.92802422
69MP0003011_delayed_dark_adaptation0.88957110
70MP0003137_abnormal_impulse_conducting0.85397852
71MP0004381_abnormal_hair_follicle0.83815797
72MP0006036_abnormal_mitochondrial_physio0.80234908
73MP0001968_abnormal_touch/_nociception0.79718957
74MP0005174_abnormal_tail_pigmentation0.79471120
75MP0005330_cardiomyopathy0.75106881
76MP0006072_abnormal_retinal_apoptosis0.74242292
77MP0001533_abnormal_skeleton_physiology0.73748242
78MP0005166_decreased_susceptibility_to0.72398999
79MP0005410_abnormal_fertilization0.71205024
80MP0005503_abnormal_tendon_morphology0.67235854
81MP0002163_abnormal_gland_morphology0.67140018
82MP0004145_abnormal_muscle_electrophysio0.66740692
83MP0008872_abnormal_physiological_respon0.66669370
84MP0003878_abnormal_ear_physiology0.64359993
85MP0005377_hearing/vestibular/ear_phenot0.64359993
86MP0002638_abnormal_pupillary_reflex0.62700737
87MP0003638_abnormal_response/metabolism_0.62594207
88MP0002136_abnormal_kidney_physiology0.59262981
89MP0009278_abnormal_bone_marrow0.58980393
90MP0001243_abnormal_dermal_layer0.56158329
91MP0001119_abnormal_female_reproductive0.54912968
92MP0002736_abnormal_nociception_after0.54680525
93MP0008873_increased_physiological_sensi0.54533026
94MP0005389_reproductive_system_phenotype0.54029426
95MP0005084_abnormal_gallbladder_morpholo0.52900437
96MP0004036_abnormal_muscle_relaxation0.52054102
97MP0005551_abnormal_eye_electrophysiolog0.51605512
98MP0002160_abnormal_reproductive_system0.50863326
99MP0001919_abnormal_reproductive_system0.47415907
100MP0004883_abnormal_blood_vessel0.46759259

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.87016398
2Abnormality of T cell number (HP:0011839)6.32196160
3Elevated erythrocyte sedimentation rate (HP:0003565)5.88417938
4Aplastic anemia (HP:0001915)4.77774946
5Severe combined immunodeficiency (HP:0004430)4.65177956
6Abnormality of T cells (HP:0002843)4.33892666
7IgG deficiency (HP:0004315)4.25662261
8Agammaglobulinemia (HP:0004432)3.98566066
9Hypoproteinemia (HP:0003075)3.91558558
10Abnormality of B cell number (HP:0010975)3.82229449
11Thyroiditis (HP:0100646)3.69633292
12Autoimmune hemolytic anemia (HP:0001890)3.67568302
13Combined immunodeficiency (HP:0005387)3.63665680
14Increased intramyocellular lipid droplets (HP:0012240)3.62351202
15B lymphocytopenia (HP:0010976)3.44428295
16Abnormality of eosinophils (HP:0001879)3.39096800
17Increased IgM level (HP:0003496)3.38053289
18Abnormality of the prostate (HP:0008775)3.16012935
19Renal Fanconi syndrome (HP:0001994)3.12722898
20Eosinophilia (HP:0001880)2.95595411
21Recurrent viral infections (HP:0004429)2.94816066
22Increased muscle lipid content (HP:0009058)2.93387424
23Recurrent bronchitis (HP:0002837)2.92827055
24Mitochondrial inheritance (HP:0001427)2.86931522
25Stomatitis (HP:0010280)2.86835343
26Amyotrophic lateral sclerosis (HP:0007354)2.82521820
27Hypoplasia of the thymus (HP:0000778)2.81120714
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.80764636
29Meningitis (HP:0001287)2.72880241
30Lymphopenia (HP:0001888)2.68523985
31Obstructive lung disease (HP:0006536)2.68038957
32Chronic obstructive pulmonary disease (HP:0006510)2.68038957
33Chronic diarrhea (HP:0002028)2.66443526
34Leukocytosis (HP:0001974)2.66414840
35Increased hepatocellular lipid droplets (HP:0006565)2.61304083
36Generalized aminoaciduria (HP:0002909)2.59132995
37Granulocytopenia (HP:0001913)2.56815239
38Recurrent fungal infections (HP:0002841)2.53877365
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.52976427
40Recurrent cutaneous fungal infections (HP:0011370)2.52967252
41Chronic mucocutaneous candidiasis (HP:0002728)2.52967252
42Myositis (HP:0100614)2.51562355
43Increased CSF lactate (HP:0002490)2.49393220
44Recurrent bacterial skin infections (HP:0005406)2.47670029
45Progressive neurologic deterioration (HP:0002344)2.47242857
46Recurrent abscess formation (HP:0002722)2.42560804
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41391580
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41391580
49Abnormal mitochondria in muscle tissue (HP:0008316)2.39790086
50Focal motor seizures (HP:0011153)2.36702307
51Pustule (HP:0200039)2.35816085
52Hypergammaglobulinemia (HP:0010702)2.30384278
53Encephalitis (HP:0002383)2.29723851
54Bronchitis (HP:0012387)2.21404646
55Pigmentary retinal degeneration (HP:0001146)2.20990453
56Recurrent skin infections (HP:0001581)2.19946957
57IgM deficiency (HP:0002850)2.18457661
58Acute necrotizing encephalopathy (HP:0006965)2.14008684
59Acute hepatic failure (HP:0006554)2.12453060
60Pancytopenia (HP:0001876)2.08590160
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08465833
62Abnormal albumin level (HP:0012116)2.06881907
63Hypoalbuminemia (HP:0003073)2.06881907
64Hepatocellular necrosis (HP:0001404)2.06741688
65Autoimmune thrombocytopenia (HP:0001973)2.05305029
66Prostate neoplasm (HP:0100787)2.04741794
67Exertional dyspnea (HP:0002875)2.03477682
68Lipid accumulation in hepatocytes (HP:0006561)2.02827974
69Abnormality of the pleura (HP:0002103)2.02056274
70Abolished electroretinogram (ERG) (HP:0000550)2.01330325
71Inflammation of the large intestine (HP:0002037)1.96570591
72Pulmonary infiltrates (HP:0002113)1.95510397
73Visual hallucinations (HP:0002367)1.94789196
74Panhypogammaglobulinemia (HP:0003139)1.94760517
75Recurrent otitis media (HP:0000403)1.94618174
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94477737
77Thrombocytosis (HP:0001894)1.93847933
78Abnormality of T cell physiology (HP:0011840)1.91975511
79J-shaped sella turcica (HP:0002680)1.91069700
80Palpebral edema (HP:0100540)1.90416157
81Vasculitis (HP:0002633)1.90346667
82Dicarboxylic aciduria (HP:0003215)1.89998221
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89998221
84Gastrointestinal infarctions (HP:0005244)1.88829593
85Skin rash (HP:0000988)1.84161948
86Chest pain (HP:0100749)1.84086857
87Joint swelling (HP:0001386)1.83743718
88Gastrointestinal inflammation (HP:0004386)1.83636842
89Increased serum lactate (HP:0002151)1.83543291
90Hepatic necrosis (HP:0002605)1.81899194
91Carpal bone hypoplasia (HP:0001498)1.78500255
92Cerebral palsy (HP:0100021)1.78105527
93Abnormality of macrophages (HP:0004311)1.76936981
94Lymphoma (HP:0002665)1.76791661
95Abnormality of male internal genitalia (HP:0000022)1.76154127
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76019822
97Abnormality of alanine metabolism (HP:0010916)1.76019822
98Hyperalaninemia (HP:0003348)1.76019822
99Congenital stationary night blindness (HP:0007642)1.75746530
100Progressive macrocephaly (HP:0004481)1.73856205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.51508785
2TXK5.85173828
3TESK25.01214302
4MUSK3.75752360
5VRK23.45819814
6MAP4K13.26513442
7SCYL22.80727463
8TESK12.78718533
9ADRBK22.16766892
10ITK2.08638161
11LIMK12.02251549
12TAOK31.90697044
13FES1.85243033
14SYK1.84718054
15BTK1.81203667
16ZAK1.79046467
17GRK71.77377735
18TEC1.73506351
19BCKDK1.69913732
20MAPKAPK31.62821408
21TBK11.49446068
22PRKCQ1.32643356
23VRK11.32603690
24LCK1.29143787
25CSK1.25647857
26RIPK41.24732521
27GRK11.22627299
28BMPR21.17651328
29CSF1R1.10018605
30EIF2AK31.02846165
31PIK3CG1.02095319
32ZAP700.99628194
33GRK60.97048345
34BUB10.95904516
35KIT0.89715906
36IKBKE0.87403482
37PDK20.86395548
38PIM20.85184756
39JAK30.84484548
40HCK0.81928822
41TNK20.81146153
42LYN0.78342630
43TLK10.67777292
44CLK10.67476745
45IKBKB0.64760477
46RPS6KA50.63582425
47MAP3K50.61356055
48TGFBR20.59607546
49CDK80.58834056
50FYN0.58391009
51FRK0.58251255
52ROCK10.57444203
53MYLK0.57320357
54INSRR0.56787115
55PIM10.56383608
56MAP3K110.55965901
57CDK190.51918750
58MAPKAPK50.49026641
59OXSR10.48705671
60MAP3K120.48139873
61OBSCN0.46591394
62IGF1R0.43764819
63IRAK40.43314608
64PRKCH0.42540387
65MAPK130.41669286
66MAP2K60.41438050
67TRPM70.40277786
68STK390.38779286
69DAPK10.37649895
70PRKCA0.36845709
71ADRBK10.36664302
72MAP4K20.35827619
73JAK10.32590064
74MAPK110.32344631
75INSR0.32045928
76ABL10.31872980
77AURKA0.31107632
78PAK10.31076141
79CAMK2A0.27619999
80GRK50.27222905
81TYK20.27102048
82WNK40.26918509
83PRKCB0.25113726
84MATK0.24641776
85MAPKAPK20.24376606
86PRKACA0.24237925
87CDK40.24220687
88CSNK1G30.22728375
89TIE10.21260171
90PRKCD0.21042678
91PDGFRB0.20115630
92NLK0.20092846
93JAK20.19809625
94WNK30.19715259
95CSNK1G10.19610174
96PRKD10.19287980
97NEK60.18065844
98RPS6KA40.17488451
99SRC0.16870427
100AURKB0.16270356

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.88395585
2Proteasome_Homo sapiens_hsa030504.17369297
3Antigen processing and presentation_Homo sapiens_hsa046123.48580631
4Hematopoietic cell lineage_Homo sapiens_hsa046403.22215239
5Autoimmune thyroid disease_Homo sapiens_hsa053202.97690194
6Oxidative phosphorylation_Homo sapiens_hsa001902.79283083
7Graft-versus-host disease_Homo sapiens_hsa053322.76416472
8T cell receptor signaling pathway_Homo sapiens_hsa046602.69173886
9Allograft rejection_Homo sapiens_hsa053302.65253549
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50447862
11Parkinsons disease_Homo sapiens_hsa050122.39877268
12Type I diabetes mellitus_Homo sapiens_hsa049402.04430457
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00428035
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.97123762
15Rheumatoid arthritis_Homo sapiens_hsa053231.86308638
16Asthma_Homo sapiens_hsa053101.73493722
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.62834356
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62048521
19Alzheimers disease_Homo sapiens_hsa050101.59313712
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48485667
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44238939
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44136091
23Viral myocarditis_Homo sapiens_hsa054161.38285635
24Huntingtons disease_Homo sapiens_hsa050161.38020204
25RNA polymerase_Homo sapiens_hsa030201.35583846
26Ribosome_Homo sapiens_hsa030101.34913517
27Salmonella infection_Homo sapiens_hsa051321.27782286
28Cardiac muscle contraction_Homo sapiens_hsa042601.22978597
29Homologous recombination_Homo sapiens_hsa034401.22940419
30Phototransduction_Homo sapiens_hsa047441.20387739
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15663801
32Measles_Homo sapiens_hsa051621.11987924
33Staphylococcus aureus infection_Homo sapiens_hsa051501.11496886
34Shigellosis_Homo sapiens_hsa051311.05862293
35Caffeine metabolism_Homo sapiens_hsa002321.03191732
36Nitrogen metabolism_Homo sapiens_hsa009101.01519253
37Malaria_Homo sapiens_hsa051440.95491420
38Herpes simplex infection_Homo sapiens_hsa051680.95112588
39Systemic lupus erythematosus_Homo sapiens_hsa053220.94818018
40Sulfur metabolism_Homo sapiens_hsa009200.93148584
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84292509
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84078026
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80704052
44Leishmaniasis_Homo sapiens_hsa051400.78948224
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78216821
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76845207
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76460702
48Peroxisome_Homo sapiens_hsa041460.71824944
49DNA replication_Homo sapiens_hsa030300.71141501
50Chemokine signaling pathway_Homo sapiens_hsa040620.70861748
51Protein export_Homo sapiens_hsa030600.69842879
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65223893
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64386944
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61131688
55Retinol metabolism_Homo sapiens_hsa008300.60304280
56HTLV-I infection_Homo sapiens_hsa051660.59142839
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58020333
58Chemical carcinogenesis_Homo sapiens_hsa052040.55376047
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.54819663
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.52444509
61Epstein-Barr virus infection_Homo sapiens_hsa051690.50350394
62Pertussis_Homo sapiens_hsa051330.47803054
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45901953
64Fanconi anemia pathway_Homo sapiens_hsa034600.45609357
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44826263
66Butanoate metabolism_Homo sapiens_hsa006500.44327022
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44062436
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43905763
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42126490
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41814522
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41189004
72Purine metabolism_Homo sapiens_hsa002300.40173585
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37156641
74Pyrimidine metabolism_Homo sapiens_hsa002400.36017705
75Prion diseases_Homo sapiens_hsa050200.35173252
76Regulation of autophagy_Homo sapiens_hsa041400.34959124
77RNA degradation_Homo sapiens_hsa030180.34473011
78Linoleic acid metabolism_Homo sapiens_hsa005910.33561996
79Olfactory transduction_Homo sapiens_hsa047400.33408557
80Influenza A_Homo sapiens_hsa051640.33001605
81Osteoclast differentiation_Homo sapiens_hsa043800.31449727
82N-Glycan biosynthesis_Homo sapiens_hsa005100.28484111
83Selenocompound metabolism_Homo sapiens_hsa004500.27909055
84Tuberculosis_Homo sapiens_hsa051520.27613955
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27326331
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25451391
87Phagosome_Homo sapiens_hsa041450.23887469
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22251511
89Ether lipid metabolism_Homo sapiens_hsa005650.21319610
90Endocytosis_Homo sapiens_hsa041440.19127956
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.18445475
92Spliceosome_Homo sapiens_hsa030400.17738377
93Apoptosis_Homo sapiens_hsa042100.17488547
94Metabolic pathways_Homo sapiens_hsa011000.17473665
95Arachidonic acid metabolism_Homo sapiens_hsa005900.16612552
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15859509
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.15630418
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15547911
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15040675
100Base excision repair_Homo sapiens_hsa034100.12373204

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