TRBJ1-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)9.19126368
2negative thymic T cell selection (GO:0045060)8.51940692
3positive regulation of gamma-delta T cell activation (GO:0046645)8.07935308
4negative regulation of cell killing (GO:0031342)7.82736738
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.82736738
6interferon-gamma production (GO:0032609)7.14432416
7regulation of isotype switching to IgG isotypes (GO:0048302)7.08210194
8thymic T cell selection (GO:0045061)7.00690990
9positive T cell selection (GO:0043368)6.98483664
10regulation of T cell tolerance induction (GO:0002664)6.75609689
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.73716458
12positive thymic T cell selection (GO:0045059)6.70838834
13T cell selection (GO:0045058)6.62215783
14regulation of gamma-delta T cell differentiation (GO:0045586)6.54004044
15response to interleukin-15 (GO:0070672)6.42759427
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.33688181
17T cell migration (GO:0072678)6.15107419
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.09747018
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.09747018
20cellular response to interleukin-15 (GO:0071350)5.94382116
21regulation of gamma-delta T cell activation (GO:0046643)5.85480471
22T cell receptor signaling pathway (GO:0050852)5.81836084
23positive regulation of tolerance induction (GO:0002645)5.57322089
24T cell costimulation (GO:0031295)5.34316030
25positive regulation of alpha-beta T cell proliferation (GO:0046641)5.27591145
26activated T cell proliferation (GO:0050798)5.26087354
27regulation of alpha-beta T cell proliferation (GO:0046640)5.25515042
28lymphocyte costimulation (GO:0031294)5.24449722
29leukocyte aggregation (GO:0070486)5.11405061
30antigen processing and presentation of endogenous antigen (GO:0019883)5.07997719
31antigen receptor-mediated signaling pathway (GO:0050851)4.87597755
32regulation of tolerance induction (GO:0002643)4.86293177
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.81473654
34regulation of natural killer cell mediated immunity (GO:0002715)4.81473654
35positive regulation of isotype switching (GO:0045830)4.68219764
36regulation of T cell receptor signaling pathway (GO:0050856)4.52492370
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.50463412
38positive regulation of natural killer cell mediated immunity (GO:0002717)4.49287283
39positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.49287283
40mast cell activation (GO:0045576)4.45904492
41regulation of interleukin-2 biosynthetic process (GO:0045076)4.43060906
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.39871495
43positive regulation of immunoglobulin mediated immune response (GO:0002891)4.38836406
44positive regulation of B cell mediated immunity (GO:0002714)4.38836406
45negative regulation of T cell mediated immunity (GO:0002710)4.37657670
46regulation of B cell receptor signaling pathway (GO:0050855)4.25995271
47positive regulation of interleukin-2 production (GO:0032743)4.18388210
48signal complex assembly (GO:0007172)4.07139731
49positive regulation of DNA recombination (GO:0045911)4.02157531
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.99377920
51regulation of isotype switching (GO:0045191)3.97681926
52T cell differentiation (GO:0030217)3.94515781
53positive regulation of humoral immune response (GO:0002922)3.93693284
54regulation of regulatory T cell differentiation (GO:0045589)3.92378911
55positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.87636950
56regulation of immunoglobulin mediated immune response (GO:0002889)3.83833422
57alpha-beta T cell activation (GO:0046631)3.81761418
58lymphocyte migration (GO:0072676)3.75594822
59alpha-beta T cell differentiation (GO:0046632)3.74952315
60V(D)J recombination (GO:0033151)3.71723762
61regulation of B cell mediated immunity (GO:0002712)3.71661738
62positive regulation of immunoglobulin production (GO:0002639)3.70753480
63regulation of cell killing (GO:0031341)3.67310951
64T cell activation (GO:0042110)3.65913505
65ribosomal small subunit assembly (GO:0000028)3.63217531
66regulation of response to tumor cell (GO:0002834)3.58542446
67positive regulation of response to tumor cell (GO:0002836)3.58542446
68positive regulation of immune response to tumor cell (GO:0002839)3.58542446
69regulation of immune response to tumor cell (GO:0002837)3.58542446
70positive regulation of cell killing (GO:0031343)3.57446252
71negative regulation of T cell receptor signaling pathway (GO:0050860)3.50333603
72heterotypic cell-cell adhesion (GO:0034113)3.47140157
73mast cell degranulation (GO:0043303)3.46337683
74mast cell activation involved in immune response (GO:0002279)3.46337683
75negative regulation of lymphocyte mediated immunity (GO:0002707)3.45897706
76cellular response to interleukin-4 (GO:0071353)3.44807330
77sequestering of actin monomers (GO:0042989)3.43549008
78immune response-activating cell surface receptor signaling pathway (GO:0002429)3.42772843
79natural killer cell activation (GO:0030101)3.42078777
80leukocyte cell-cell adhesion (GO:0007159)3.41305494
81regulation of response to interferon-gamma (GO:0060330)3.37412034
82regulation of immunoglobulin production (GO:0002637)3.37324730
83T cell proliferation (GO:0042098)3.36540910
84T cell homeostasis (GO:0043029)3.35053463
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.29960175
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.29679132
87positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.20230089
88regulation of interleukin-2 production (GO:0032663)3.17949456
89Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16643872
90positive regulation of lymphocyte mediated immunity (GO:0002708)3.15666361
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13923249
92positive regulation of interleukin-4 production (GO:0032753)3.13734182
93positive regulation of calcium-mediated signaling (GO:0050850)3.12801951
94regulation of defense response to virus by virus (GO:0050690)3.10861511
95regulation of interleukin-12 biosynthetic process (GO:0045075)3.09827373
96response to interleukin-4 (GO:0070670)3.09165471
97regulation of lymphocyte mediated immunity (GO:0002706)3.08293753
98B cell receptor signaling pathway (GO:0050853)3.08011768
99regulation of B cell differentiation (GO:0045577)3.07949594
100positive regulation of T cell activation (GO:0050870)3.06845140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.24680070
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.39390599
3E2F7_22180533_ChIP-Seq_HELA_Human5.34718515
4RUNX_20019798_ChIP-Seq_JUKART_Human4.07568943
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.84504385
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.71397420
7MYC_22102868_ChIP-Seq_BL_Human3.60109045
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.59739444
9MYB_26560356_Chip-Seq_TH2_Human3.44368027
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.38378030
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.35190737
12IRF8_22096565_ChIP-ChIP_GC-B_Human3.27199559
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04421616
14MAF_26560356_Chip-Seq_TH1_Human2.99934294
15UTX_26944678_Chip-Seq_JUKART_Human2.78885399
16MYB_26560356_Chip-Seq_TH1_Human2.71021402
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.70806381
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.65018385
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38729758
20GATA3_27048872_Chip-Seq_THYMUS_Human2.36220655
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.23307427
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10596946
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07819139
24MAF_26560356_Chip-Seq_TH2_Human2.06333805
25VDR_21846776_ChIP-Seq_THP-1_Human2.03353790
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.96179116
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94151566
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92711804
29SPI1_23547873_ChIP-Seq_NB4_Human1.88947221
30TCF7_22412390_ChIP-Seq_EML_Mouse1.79464622
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78799557
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77839091
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72843545
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.71939926
35SCL_19346495_ChIP-Seq_HPC-7_Human1.70104346
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69660912
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.67409472
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.66229390
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65623270
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64884187
41KDM2B_26808549_Chip-Seq_DND41_Human1.63130390
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.62008085
43VDR_24763502_ChIP-Seq_THP-1_Human1.60230856
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58491584
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.57326868
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52395250
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.49985341
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45778508
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41981997
50CIITA_25753668_ChIP-Seq_RAJI_Human1.41979787
51SPI1_23127762_ChIP-Seq_K562_Human1.40826576
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40264846
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33011020
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30633798
55GATA3_26560356_Chip-Seq_TH2_Human1.28413595
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23089179
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19838283
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16651786
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16646035
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15444654
61VDR_23849224_ChIP-Seq_CD4+_Human1.14289701
62PU_27001747_Chip-Seq_BMDM_Mouse1.12413230
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12182139
64FOXP3_21729870_ChIP-Seq_TREG_Human1.11891827
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11113356
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.06711478
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06687558
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02072222
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01596957
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00981059
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97934634
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97643529
73ELK1_19687146_ChIP-ChIP_HELA_Human0.97357661
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96164069
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93906764
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93191115
77PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92586414
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92036025
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91978066
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90972343
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84105009
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.83824868
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83582725
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80562993
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.80079968
86SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79076932
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78397248
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.76366980
89VDR_24787735_ChIP-Seq_THP-1_Human0.76337245
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75692604
91NCOR1_26117541_ChIP-Seq_K562_Human0.75265519
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.74869754
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.74471394
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72033736
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68608677
96GATA1_19941826_ChIP-Seq_K562_Human0.68288883
97XRN2_22483619_ChIP-Seq_HELA_Human0.66442714
98GATA2_19941826_ChIP-Seq_K562_Human0.66098788
99KDM5A_27292631_Chip-Seq_BREAST_Human0.62482231
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62412948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.11400216
2MP0005671_abnormal_response_to5.39851274
3MP0000685_abnormal_immune_system3.61641363
4MP0001835_abnormal_antigen_presentation3.45045095
5MP0001800_abnormal_humoral_immune3.31837441
6MP0009333_abnormal_splenocyte_physiolog3.26447381
7MP0000703_abnormal_thymus_morphology3.10641135
8MP0002398_abnormal_bone_marrow3.10288656
9MP0002420_abnormal_adaptive_immunity3.03588841
10MP0001819_abnormal_immune_cell2.98349429
11MP0005000_abnormal_immune_tolerance2.82621756
12MP0002166_altered_tumor_susceptibility2.81609685
13MP0002723_abnormal_immune_serum2.80842418
14MP0000716_abnormal_immune_system2.62377471
15MP0001790_abnormal_immune_system2.59130361
16MP0005387_immune_system_phenotype2.59130361
17MP0002452_abnormal_antigen_presenting2.58344044
18MP0002722_abnormal_immune_system2.56610552
19MP0002405_respiratory_system_inflammati2.53351520
20MP0009785_altered_susceptibility_to2.47860509
21MP0005025_abnormal_response_to2.47490821
22MP0003300_gastrointestinal_ulcer2.43834158
23MP0001873_stomach_inflammation2.41133973
24MP0000689_abnormal_spleen_morphology2.38385346
25MP0002396_abnormal_hematopoietic_system2.36112716
26MP0002006_tumorigenesis2.33361480
27MP0006082_CNS_inflammation2.32603597
28MP0002429_abnormal_blood_cell2.14307320
29MP0003436_decreased_susceptibility_to2.07671639
30MP0004947_skin_inflammation2.05407107
31MP0010155_abnormal_intestine_physiology2.05205627
32MP0002148_abnormal_hypersensitivity_rea1.98004230
33MP0003724_increased_susceptibility_to1.94238357
34MP0003866_abnormal_defecation1.87938864
35MP0002419_abnormal_innate_immunity1.86482630
36MP0005464_abnormal_platelet_physiology1.85637268
37MP0000858_altered_metastatic_potential1.80119511
38MP0002933_joint_inflammation1.79250355
39MP0004381_abnormal_hair_follicle1.72526371
40MP0001845_abnormal_inflammatory_respons1.69800611
41MP0006054_spinal_hemorrhage1.64159832
42MP0003448_altered_tumor_morphology1.48655439
43MP0004808_abnormal_hematopoietic_stem1.45953424
44MP0000465_gastrointestinal_hemorrhage1.35915492
45MP0010352_gastrointestinal_tract_polyps1.34708174
46MP0001853_heart_inflammation1.27281593
47MP0005075_abnormal_melanosome_morpholog1.26703782
48MP0002019_abnormal_tumor_incidence1.20720189
49MP0003303_peritoneal_inflammation1.15998357
50MP0002009_preneoplasia1.09259376
51MP0002132_abnormal_respiratory_system1.07704793
52MP0003045_fibrosis1.07066626
53MP0000490_abnormal_crypts_of1.02981533
54MP0008469_abnormal_protein_level0.99685853
55MP0005397_hematopoietic_system_phenotyp0.94793124
56MP0001545_abnormal_hematopoietic_system0.94793124
57MP0008057_abnormal_DNA_replication0.92080790
58MP0004510_myositis0.91534156
59MP0004957_abnormal_blastocyst_morpholog0.91032982
60MP0001533_abnormal_skeleton_physiology0.90854394
61MP0001851_eye_inflammation0.88979147
62MP0005023_abnormal_wound_healing0.87617458
63MP0003077_abnormal_cell_cycle0.83455259
64MP0008961_abnormal_basal_metabolism0.82329182
65MP0010094_abnormal_chromosome_stability0.81531764
66MP0005310_abnormal_salivary_gland0.74019345
67MP0002998_abnormal_bone_remodeling0.67921811
68MP0009763_increased_sensitivity_to0.66124830
69MP0009765_abnormal_xenobiotic_induced0.63815893
70MP0003693_abnormal_embryo_hatching0.62726316
71MP0005076_abnormal_cell_differentiation0.59804952
72MP0000609_abnormal_liver_physiology0.57163708
73MP0000604_amyloidosis0.54940793
74MP0003453_abnormal_keratinocyte_physiol0.54484787
75MP0000477_abnormal_intestine_morphology0.54467179
76MP0002693_abnormal_pancreas_physiology0.54196442
77MP0000920_abnormal_myelination0.50936770
78MP0004185_abnormal_adipocyte_glucose0.50698526
79MP0002136_abnormal_kidney_physiology0.49500302
80MP0003279_aneurysm0.48780694
81MP0003795_abnormal_bone_structure0.47627967
82MP0009278_abnormal_bone_marrow0.47389222
83MP0001243_abnormal_dermal_layer0.46539542
84MP0009764_decreased_sensitivity_to0.46194747
85MP0001958_emphysema0.44891996
86MP0008873_increased_physiological_sensi0.43496083
87MP0000350_abnormal_cell_proliferation0.42936541
88MP0000249_abnormal_blood_vessel0.42168418
89MP0002083_premature_death0.42069647
90MP0001663_abnormal_digestive_system0.40887895
91MP0005174_abnormal_tail_pigmentation0.40833128
92MP0005166_decreased_susceptibility_to0.40577179
93MP0003111_abnormal_nucleus_morphology0.40167722
94MP0003091_abnormal_cell_migration0.39984678
95MP0001191_abnormal_skin_condition0.39133175
96MP0008770_decreased_survivor_rate0.37844428
97MP0001730_embryonic_growth_arrest0.37644323
98MP0008058_abnormal_DNA_repair0.37638995
99MP0000367_abnormal_coat/_hair0.37278977
100MP0001348_abnormal_lacrimal_gland0.36913906

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.15071392
2Abnormality of T cell number (HP:0011839)8.73779857
3Elevated erythrocyte sedimentation rate (HP:0003565)5.64099725
4Myositis (HP:0100614)5.58229386
5Abnormality of T cells (HP:0002843)5.49455613
6Severe combined immunodeficiency (HP:0004430)5.47931736
7Combined immunodeficiency (HP:0005387)5.42886000
8Recurrent viral infections (HP:0004429)4.81736719
9Panhypogammaglobulinemia (HP:0003139)4.49837125
10Chronic otitis media (HP:0000389)4.36319736
11Eosinophilia (HP:0001880)4.35894465
12Nasal polyposis (HP:0100582)4.30581102
13Abnormality of eosinophils (HP:0001879)4.23292802
14Pustule (HP:0200039)4.17179302
15IgG deficiency (HP:0004315)4.12867278
16Joint swelling (HP:0001386)3.96743204
17Recurrent fungal infections (HP:0002841)3.96338404
18Stomatitis (HP:0010280)3.90252993
19Recurrent bronchitis (HP:0002837)3.88193091
20Thyroiditis (HP:0100646)3.86218014
21Autoimmune hemolytic anemia (HP:0001890)3.67490518
22Granulocytopenia (HP:0001913)3.66395722
23Leukocytosis (HP:0001974)3.64590443
24Encephalitis (HP:0002383)3.63493219
25Abnormality of the nasal mucosa (HP:0000433)3.53086643
26Optic neuritis (HP:0100653)3.49644374
27Retrobulbar optic neuritis (HP:0100654)3.49644374
28IgM deficiency (HP:0002850)3.41368283
29Increased IgM level (HP:0003496)3.34944887
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.32702411
31Keratoconjunctivitis sicca (HP:0001097)3.28255837
32B lymphocytopenia (HP:0010976)3.26637973
33Abnormality of B cell number (HP:0010975)3.26637973
34Spontaneous hematomas (HP:0007420)3.24251684
35Recurrent abscess formation (HP:0002722)3.22278410
36Orchitis (HP:0100796)3.20158516
37Meningitis (HP:0001287)3.19322004
38Lymphopenia (HP:0001888)3.15303099
39Eczematoid dermatitis (HP:0000976)3.14666787
40Hypoplasia of the thymus (HP:0000778)3.04947517
41Abnormality of cells of the lymphoid lineage (HP:0012140)3.02591416
42Thrombocytosis (HP:0001894)2.96909531
43Abnormality of the fingertips (HP:0001211)2.95906074
44Keratoconjunctivitis (HP:0001096)2.94936704
45Chronic diarrhea (HP:0002028)2.81427267
46Recurrent cutaneous fungal infections (HP:0011370)2.79977231
47Chronic mucocutaneous candidiasis (HP:0002728)2.79977231
48Abnormal platelet volume (HP:0011876)2.65421094
49Autoimmune thrombocytopenia (HP:0001973)2.60173038
50Lymphoma (HP:0002665)2.59581588
51Recurrent bacterial skin infections (HP:0005406)2.55276833
52Abnormality of T cell physiology (HP:0011840)2.52970100
53Verrucae (HP:0200043)2.45747932
54Papilloma (HP:0012740)2.45747932
55Gastrointestinal infarctions (HP:0005244)2.44420713
56Hemoptysis (HP:0002105)2.41459509
57Hypergammaglobulinemia (HP:0010702)2.41170669
58Basal cell carcinoma (HP:0002671)2.38527934
59Mediastinal lymphadenopathy (HP:0100721)2.38221317
60Recurrent otitis media (HP:0000403)2.37677346
61Pulmonary embolism (HP:0002204)2.34750704
62Arterial thrombosis (HP:0004420)2.34227796
63Increased mean platelet volume (HP:0011877)2.32440647
64Recurrent skin infections (HP:0001581)2.31942358
65Recurrent sinusitis (HP:0011108)2.31349297
66Vasculitis (HP:0002633)2.26433067
67Epistaxis (HP:0000421)2.24970634
68Pulmonary infiltrates (HP:0002113)2.23205916
69Chronic sinusitis (HP:0011109)2.23105247
70Inflammation of the large intestine (HP:0002037)2.17781548
71Bronchitis (HP:0012387)2.17293742
72Agammaglobulinemia (HP:0004432)2.16367643
73Gastrointestinal inflammation (HP:0004386)2.12882062
74Prolonged bleeding time (HP:0003010)2.12296822
75Chronic obstructive pulmonary disease (HP:0006510)2.12196603
76Obstructive lung disease (HP:0006536)2.12196603
77Abnormality of oral frenula (HP:0000190)2.07566011
78Increased IgE level (HP:0003212)2.00219813
79Amaurosis fugax (HP:0100576)1.97235111
80Petechiae (HP:0000967)1.94277589
81Cellular immunodeficiency (HP:0005374)1.89796742
82Striae distensae (HP:0001065)1.88336704
8311 pairs of ribs (HP:0000878)1.86674237
84Spondylolisthesis (HP:0003302)1.85385758
85Chest pain (HP:0100749)1.85371591
86Gingival bleeding (HP:0000225)1.84728347
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.83190698
88Trigonocephaly (HP:0000243)1.82557767
89Colon cancer (HP:0003003)1.82541966
90Bicuspid aortic valve (HP:0001647)1.82067714
91Hypoproteinemia (HP:0003075)1.81853048
92Abnormality of the pleura (HP:0002103)1.80884719
93Toxemia of pregnancy (HP:0100603)1.79824212
94Broad palm (HP:0001169)1.79814167
95Bronchiectasis (HP:0002110)1.75982484
96Aortic aneurysm (HP:0004942)1.75656223
97Gangrene (HP:0100758)1.74851080
98Volvulus (HP:0002580)1.73166020
99Periodontitis (HP:0000704)1.69391572
100Abnormal foot bone ossification (HP:0010675)1.67208530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.20860368
2MAP4K15.95534077
3ITK3.67378470
4ZAP703.14499599
5STK102.95859500
6JAK32.74069270
7NLK2.56627172
8GRK62.46731186
9MST42.27510162
10FGFR42.12028489
11TYK22.07791766
12LCK1.98993414
13CSK1.79353332
14IKBKE1.75653134
15JAK11.74536211
16MAP3K141.74155470
17EEF2K1.69831952
18TEC1.67501922
19CLK11.66003872
20SYK1.60821297
21FGFR31.47067401
22PRKCH1.43272666
23BTK1.36966979
24LRRK21.36120753
25MELK1.30769681
26MAP3K131.30739707
27PKN21.28934175
28NME21.27096595
29HCK1.25616926
30MAP3K101.23239576
31MAP3K71.16559946
32PRKCQ1.16280695
33BLK1.16232154
34BMPR21.09185537
35MARK31.04024624
36TBK11.03554727
37MAP2K61.02471677
38CDK80.98551987
39PIM10.98080498
40CDK40.97832455
41KDR0.93203515
42PRPF4B0.92707180
43SIK20.90087692
44TESK20.86589802
45FES0.85168458
46EPHB10.84394352
47IKBKB0.78034489
48EPHA30.77526042
49SIK30.76892690
50LYN0.72583958
51KIT0.71567230
52CDK90.70657110
53MARK20.67052680
54PDGFRB0.64432769
55JAK20.64195937
56PASK0.63574076
57IRAK40.62938638
58FLT30.60942100
59STK40.60244864
60FGFR10.59207094
61CSF1R0.54462773
62RPS6KA40.53969844
63ACVR1B0.52400173
64TGFBR20.52255402
65FYN0.51240002
66TRIB30.49168998
67TNK20.45518494
68CDC70.45436618
69HIPK20.45308078
70PDK10.44519427
71IGF1R0.43673835
72TYRO30.42796939
73ALK0.42227284
74MAPK70.42172851
75INSR0.41799628
76FGFR20.38266695
77RPS6KB20.37527264
78CDK60.36722872
79TAOK10.35764162
80PRKD20.34751671
81TGFBR10.33594502
82PTK60.32467954
83DMPK0.29496113
84RPS6KA60.29479069
85CDK120.29353428
86ADRBK20.28437488
87MAPK110.27724135
88MAPK30.27466503
89MAPK40.26184963
90MAPK120.25396934
91SGK30.24631838
92CHUK0.24295141
93RPS6KC10.23890264
94RPS6KL10.23890264
95MAP3K80.23798981
96MAPK90.21216503
97SIK10.20702061
98ILK0.20543946
99TRPM70.20059600
100TTN0.18358531

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.71771300
2Graft-versus-host disease_Homo sapiens_hsa053324.66390667
3T cell receptor signaling pathway_Homo sapiens_hsa046604.49011465
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.88780555
5Antigen processing and presentation_Homo sapiens_hsa046123.24309492
6Measles_Homo sapiens_hsa051622.81485955
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68133426
8Hematopoietic cell lineage_Homo sapiens_hsa046402.66303605
9Allograft rejection_Homo sapiens_hsa053302.61917141
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.48156784
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.06488987
12Viral myocarditis_Homo sapiens_hsa054161.80882850
13Type I diabetes mellitus_Homo sapiens_hsa049401.71408803
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.70970073
15Leishmaniasis_Homo sapiens_hsa051401.65748925
16Autoimmune thyroid disease_Homo sapiens_hsa053201.64280225
17Osteoclast differentiation_Homo sapiens_hsa043801.54480376
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.52985661
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49372871
20Non-homologous end-joining_Homo sapiens_hsa034501.46841414
21Ribosome_Homo sapiens_hsa030101.42210492
22Chemokine signaling pathway_Homo sapiens_hsa040621.39924723
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34557875
24B cell receptor signaling pathway_Homo sapiens_hsa046621.34133369
25Herpes simplex infection_Homo sapiens_hsa051681.34002998
26Colorectal cancer_Homo sapiens_hsa052101.32135541
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30650155
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21699697
29Hepatitis B_Homo sapiens_hsa051611.21693404
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20382148
31Acute myeloid leukemia_Homo sapiens_hsa052211.19760029
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18782016
33HTLV-I infection_Homo sapiens_hsa051661.15119320
34Pancreatic cancer_Homo sapiens_hsa052121.12046249
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10239538
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08262286
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05795197
38Toxoplasmosis_Homo sapiens_hsa051451.02609762
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01302321
40Apoptosis_Homo sapiens_hsa042100.96896311
41Shigellosis_Homo sapiens_hsa051310.92945193
42Influenza A_Homo sapiens_hsa051640.91251819
43Platelet activation_Homo sapiens_hsa046110.89547335
44TNF signaling pathway_Homo sapiens_hsa046680.87053597
45Spliceosome_Homo sapiens_hsa030400.82622592
46Chronic myeloid leukemia_Homo sapiens_hsa052200.82518738
47Viral carcinogenesis_Homo sapiens_hsa052030.82486491
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82147683
49DNA replication_Homo sapiens_hsa030300.77715542
50Epstein-Barr virus infection_Homo sapiens_hsa051690.77371166
51Mismatch repair_Homo sapiens_hsa034300.73665156
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72354462
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71244555
54Asthma_Homo sapiens_hsa053100.70353509
55Staphylococcus aureus infection_Homo sapiens_hsa051500.64093740
56Hepatitis C_Homo sapiens_hsa051600.60492426
57VEGF signaling pathway_Homo sapiens_hsa043700.59266110
58Salmonella infection_Homo sapiens_hsa051320.58281302
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56109497
60Thyroid cancer_Homo sapiens_hsa052160.53712921
61Non-small cell lung cancer_Homo sapiens_hsa052230.53683474
62Legionellosis_Homo sapiens_hsa051340.50744464
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.50698695
64Tuberculosis_Homo sapiens_hsa051520.49054905
65Rheumatoid arthritis_Homo sapiens_hsa053230.48474376
66Malaria_Homo sapiens_hsa051440.47542972
67Notch signaling pathway_Homo sapiens_hsa043300.46696280
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44453958
69Endometrial cancer_Homo sapiens_hsa052130.43427942
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42098274
71Endocytosis_Homo sapiens_hsa041440.41602912
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40816970
73Pertussis_Homo sapiens_hsa051330.39767808
74FoxO signaling pathway_Homo sapiens_hsa040680.37335857
75Prostate cancer_Homo sapiens_hsa052150.37273803
76Small cell lung cancer_Homo sapiens_hsa052220.37187968
77Nucleotide excision repair_Homo sapiens_hsa034200.37130647
78RNA degradation_Homo sapiens_hsa030180.37126239
79Adherens junction_Homo sapiens_hsa045200.35403951
80Cell cycle_Homo sapiens_hsa041100.34269481
81Rap1 signaling pathway_Homo sapiens_hsa040150.33973248
82Prolactin signaling pathway_Homo sapiens_hsa049170.33776970
83Base excision repair_Homo sapiens_hsa034100.32568136
84p53 signaling pathway_Homo sapiens_hsa041150.32107292
85mRNA surveillance pathway_Homo sapiens_hsa030150.30342231
86Proteasome_Homo sapiens_hsa030500.29064468
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26626050
88Renal cell carcinoma_Homo sapiens_hsa052110.24706461
89mTOR signaling pathway_Homo sapiens_hsa041500.24442572
90MicroRNAs in cancer_Homo sapiens_hsa052060.23920621
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.23839511
92Systemic lupus erythematosus_Homo sapiens_hsa053220.20321745
93MAPK signaling pathway_Homo sapiens_hsa040100.19955899
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18741356
95Insulin resistance_Homo sapiens_hsa049310.18286052
96RNA transport_Homo sapiens_hsa030130.17314167
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16696325
98Pentose phosphate pathway_Homo sapiens_hsa000300.16405875
99African trypanosomiasis_Homo sapiens_hsa051430.16178970
100Inositol phosphate metabolism_Homo sapiens_hsa005620.15230655

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