TRBC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.57786882
2positive regulation of gamma-delta T cell activation (GO:0046645)8.36249606
3regulation of gamma-delta T cell differentiation (GO:0045586)8.33366659
4positive T cell selection (GO:0043368)8.07120249
5regulation of gamma-delta T cell activation (GO:0046643)7.45305290
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.37306447
7negative thymic T cell selection (GO:0045060)7.35229688
8T cell selection (GO:0045058)7.18402723
9positive thymic T cell selection (GO:0045059)7.14537621
10negative regulation of cell killing (GO:0031342)6.77024506
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.77024506
12V(D)J recombination (GO:0033151)6.73176684
13thymic T cell selection (GO:0045061)6.57040535
14* T cell receptor signaling pathway (GO:0050852)6.41584187
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.36871275
16cellular response to interleukin-15 (GO:0071350)6.00184501
17response to interleukin-15 (GO:0070672)5.88835550
18interferon-gamma production (GO:0032609)5.86748185
19negative regulation of thymocyte apoptotic process (GO:0070244)5.61264558
20regulation of isotype switching to IgG isotypes (GO:0048302)5.55593138
21* T cell costimulation (GO:0031295)5.51311174
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.49413344
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49413344
24* lymphocyte costimulation (GO:0031294)5.48447432
25activated T cell proliferation (GO:0050798)5.37279210
26leukocyte aggregation (GO:0070486)5.31355376
27* antigen receptor-mediated signaling pathway (GO:0050851)5.21668844
28regulation of T cell receptor signaling pathway (GO:0050856)5.06990315
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01243014
30regulation of T cell tolerance induction (GO:0002664)4.99110013
31cytidine deamination (GO:0009972)4.96090240
32cytidine metabolic process (GO:0046087)4.96090240
33cytidine catabolic process (GO:0006216)4.96090240
34T cell differentiation (GO:0030217)4.76987911
35sequestering of actin monomers (GO:0042989)4.64690462
36regulation of interleukin-2 biosynthetic process (GO:0045076)4.60056030
37pyrimidine ribonucleoside catabolic process (GO:0046133)4.56853527
38regulation of regulatory T cell differentiation (GO:0045589)4.53995818
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.52045481
40antigen processing and presentation of endogenous antigen (GO:0019883)4.50544316
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.48950351
42positive regulation of interleukin-2 production (GO:0032743)4.48104740
43T cell migration (GO:0072678)4.42727950
44alpha-beta T cell differentiation (GO:0046632)4.37986057
45positive regulation of granulocyte differentiation (GO:0030854)4.36938896
46mast cell activation (GO:0045576)4.36419842
47regulation of defense response to virus by virus (GO:0050690)4.27536675
48regulation of thymocyte apoptotic process (GO:0070243)4.17663516
49alpha-beta T cell activation (GO:0046631)4.17488377
50positive regulation of calcium-mediated signaling (GO:0050850)4.15036196
51DNA deamination (GO:0045006)4.11697136
52regulation of T cell chemotaxis (GO:0010819)4.07034147
53positive regulation of T cell chemotaxis (GO:0010820)4.07034147
54positive regulation of tolerance induction (GO:0002645)4.04924606
55T cell activation (GO:0042110)4.04033429
56mucosal-associated lymphoid tissue development (GO:0048537)4.02431907
57Peyers patch development (GO:0048541)4.02431907
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.93268935
59antigen processing and presentation via MHC class Ib (GO:0002475)3.88274121
60mast cell activation involved in immune response (GO:0002279)3.86569670
61mast cell degranulation (GO:0043303)3.86569670
62regulation of B cell receptor signaling pathway (GO:0050855)3.80343406
63regulation of activation of Janus kinase activity (GO:0010533)3.77686355
64regulation of chronic inflammatory response (GO:0002676)3.74796435
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.73152134
66regulation of B cell differentiation (GO:0045577)3.71116243
67tolerance induction (GO:0002507)3.70757633
68dendritic cell chemotaxis (GO:0002407)3.70102569
69regulation of alpha-beta T cell proliferation (GO:0046640)3.69307744
70somatic cell DNA recombination (GO:0016444)3.67692671
71somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.67692671
72T cell homeostasis (GO:0043029)3.62711283
73positive regulation of B cell differentiation (GO:0045579)3.60068034
74negative regulation of T cell receptor signaling pathway (GO:0050860)3.59069029
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.57940063
76positive regulation of natural killer cell mediated immunity (GO:0002717)3.57940063
77regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.57742196
78regulation of lymphocyte chemotaxis (GO:1901623)3.57682097
79regulation of response to interferon-gamma (GO:0060330)3.57248205
80regulation of T cell mediated cytotoxicity (GO:0001914)3.56211719
81regulation of natural killer cell mediated immunity (GO:0002715)3.53360668
82regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53360668
83regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.50936088
84regulation of leukocyte mediated cytotoxicity (GO:0001910)3.50917489
85positive regulation of interleukin-4 production (GO:0032753)3.50569582
86* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.49763394
87regulation of tolerance induction (GO:0002643)3.48769456
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.43495421
89NIK/NF-kappaB signaling (GO:0038061)3.43031005
90lymph node development (GO:0048535)3.42744341
91regulation of interleukin-2 production (GO:0032663)3.42684692
92negative regulation of T cell apoptotic process (GO:0070233)3.40228636
93lymphocyte migration (GO:0072676)3.40156530
94somatic diversification of immune receptors (GO:0002200)3.39485960
95T cell lineage commitment (GO:0002360)3.37509120
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.34003314
97positive regulation of lymphocyte mediated immunity (GO:0002708)3.33671314
98actin nucleation (GO:0045010)3.30682854
99cellular response to interleukin-4 (GO:0071353)3.29657423
100regulation of isotype switching (GO:0045191)3.29328349
101positive regulation of humoral immune response (GO:0002922)3.27186896
102positive regulation of isotype switching (GO:0045830)3.26967950
103negative regulation of T cell mediated immunity (GO:0002710)3.26472778
104T cell differentiation in thymus (GO:0033077)3.25525168
105negative regulation of leukocyte mediated immunity (GO:0002704)3.24846220
106* positive regulation of T cell activation (GO:0050870)3.21343415
107natural killer cell activation (GO:0030101)3.20810890
108regulation of cell killing (GO:0031341)3.20481288
109dendritic cell migration (GO:0036336)3.19684047
110T-helper cell differentiation (GO:0042093)3.19444377
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.19444377
112lymphocyte differentiation (GO:0030098)3.16471389
113regulation of alpha-beta T cell activation (GO:0046634)3.16015078
114lymphocyte chemotaxis (GO:0048247)3.15522919
115positive regulation of T cell differentiation (GO:0045582)3.15252497
116T cell mediated immunity (GO:0002456)3.15045029
117positive regulation of T cell mediated immunity (GO:0002711)3.14887637
118cellular defense response (GO:0006968)3.14268508
119regulation of interleukin-4 production (GO:0032673)3.12645293
120positive regulation of cell killing (GO:0031343)3.12510021
121negative regulation of lymphocyte mediated immunity (GO:0002707)3.12383742
122regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12151703
123negative regulation of viral genome replication (GO:0045071)3.11033030
124positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10845336
125positive regulation of uterine smooth muscle contraction (GO:0070474)3.09974792
126positive regulation of lymphocyte migration (GO:2000403)3.09918994
127chemokine-mediated signaling pathway (GO:0070098)3.09720686
128positive regulation of alpha-beta T cell activation (GO:0046635)3.08700244
129positive regulation of defense response to virus by host (GO:0002230)3.08295822
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07987623
131lymphocyte homeostasis (GO:0002260)3.07650528
132* regulation of T cell activation (GO:0050863)3.06058892
133regulation of T cell differentiation (GO:0045580)3.03163338
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02440275
135CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.02251009
136leukocyte cell-cell adhesion (GO:0007159)3.01738848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.35694686
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.80693248
3E2F7_22180533_ChIP-Seq_HELA_Human5.26644587
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.79888846
5MYC_22102868_ChIP-Seq_BL_Human3.65570902
6RUNX_20019798_ChIP-Seq_JUKART_Human3.65150183
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62086503
8MYB_26560356_Chip-Seq_TH2_Human3.50756066
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.46829831
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34339512
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.20340560
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19974092
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.18076636
14UTX_26944678_Chip-Seq_JUKART_Human2.99660528
15MAF_26560356_Chip-Seq_TH1_Human2.99190382
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78189699
17MYB_26560356_Chip-Seq_TH1_Human2.69975660
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59154079
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.36744735
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34636629
21GATA3_27048872_Chip-Seq_THYMUS_Human2.34506269
22VDR_21846776_ChIP-Seq_THP-1_Human2.26527245
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21008033
24MAF_26560356_Chip-Seq_TH2_Human2.12913835
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.08717102
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02299733
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94026451
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93803008
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91492501
30TCF7_22412390_ChIP-Seq_EML_Mouse1.88815980
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.87691360
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78174812
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77730227
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71734489
35SPI1_23547873_ChIP-Seq_NB4_Human1.71303986
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68444772
37CIITA_25753668_ChIP-Seq_RAJI_Human1.65615025
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62431987
39KDM2B_26808549_Chip-Seq_DND41_Human1.60912850
40VDR_24763502_ChIP-Seq_THP-1_Human1.59331498
41SCL_19346495_ChIP-Seq_HPC-7_Human1.56956058
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55526233
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53416268
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53403219
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52950179
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50789093
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49279611
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49239569
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.47977244
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46456102
51FOXP3_21729870_ChIP-Seq_TREG_Human1.35923279
52VDR_23849224_ChIP-Seq_CD4+_Human1.34017884
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.32884003
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.31049972
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28651383
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28436191
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28186916
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27518480
59SPI1_23127762_ChIP-Seq_K562_Human1.26452535
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20571518
61BCL6_27268052_Chip-Seq_Bcells_Human1.18623848
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.14690820
63GATA3_26560356_Chip-Seq_TH2_Human1.14238874
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12624344
65GATA1_22025678_ChIP-Seq_K562_Human1.10734766
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10495246
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07980229
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06095761
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04003751
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02956968
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02555472
72PU_27001747_Chip-Seq_BMDM_Mouse0.99195023
73KDM2B_26808549_Chip-Seq_JURKAT_Human0.98623366
74ELK3_25401928_ChIP-Seq_HUVEC_Human0.98550573
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96578345
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96212870
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95744285
78BCOR_27268052_Chip-Seq_Bcells_Human0.93788058
79GATA3_26560356_Chip-Seq_TH1_Human0.93485261
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92777265
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91849397
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90859353
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90694477
84P300_27268052_Chip-Seq_Bcells_Human0.90116443
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89940502
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89237549
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88206603
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87036308
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86939671
90XRN2_22483619_ChIP-Seq_HELA_Human0.86476249
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86458612
92ELK1_19687146_ChIP-ChIP_HELA_Human0.83725417
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82373516
94EST1_17652178_ChIP-ChIP_JURKAT_Human0.82367043
95SPI1_20517297_ChIP-Seq_HL60_Human0.82001744
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81504147
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81477217
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81345989
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.80784565
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80293991
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80173741
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79837067
103RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79718947
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79100482
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79000998
106RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78571028
107CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78536760
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78404489
109GABP_17652178_ChIP-ChIP_JURKAT_Human0.76789975
110MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74126604
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.72621118
112KDM5A_27292631_Chip-Seq_BREAST_Human0.71866867
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71176175
114MYC_18555785_ChIP-Seq_MESCs_Mouse0.70913513
115SA1_27219007_Chip-Seq_Bcells_Human0.70263298
116VDR_24787735_ChIP-Seq_THP-1_Human0.68485725
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67735602
118TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67614524
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.66729406
120IKZF1_21737484_ChIP-ChIP_HCT116_Human0.66227724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.36539231
2MP0005671_abnormal_response_to5.06395788
3MP0002166_altered_tumor_susceptibility4.62992865
4MP0002006_tumorigenesis3.68745820
5MP0000685_abnormal_immune_system3.57143264
6MP0001835_abnormal_antigen_presentation3.45926814
7MP0000703_abnormal_thymus_morphology3.40524232
8MP0002398_abnormal_bone_marrow2.92385152
9MP0009333_abnormal_splenocyte_physiolog2.85980292
10MP0009785_altered_susceptibility_to2.85276006
11MP0001800_abnormal_humoral_immune2.83791577
12MP0006082_CNS_inflammation2.75682824
13MP0005387_immune_system_phenotype2.65626292
14MP0001790_abnormal_immune_system2.65626292
15MP0002420_abnormal_adaptive_immunity2.63537086
16MP0005000_abnormal_immune_tolerance2.62263720
17MP0001819_abnormal_immune_cell2.59649321
18MP0002723_abnormal_immune_serum2.57036925
19MP0002722_abnormal_immune_system2.55213830
20MP0004947_skin_inflammation2.51274358
21MP0000716_abnormal_immune_system2.47669613
22MP0010155_abnormal_intestine_physiology2.46866128
23MP0002405_respiratory_system_inflammati2.37598810
24MP0000689_abnormal_spleen_morphology2.22634963
25MP0005025_abnormal_response_to2.20413523
26MP0002452_abnormal_antigen_presenting2.16969384
27MP0003724_increased_susceptibility_to2.11162652
28MP0002933_joint_inflammation2.10523856
29MP0002132_abnormal_respiratory_system2.09264119
30MP0002429_abnormal_blood_cell1.99294217
31MP0002396_abnormal_hematopoietic_system1.95183371
32MP0001873_stomach_inflammation1.94725479
33MP0003866_abnormal_defecation1.92181951
34MP0003300_gastrointestinal_ulcer1.68973861
35MP0004381_abnormal_hair_follicle1.64237075
36MP0004808_abnormal_hematopoietic_stem1.61898127
37MP0010094_abnormal_chromosome_stability1.53601653
38MP0001845_abnormal_inflammatory_respons1.52541430
39MP0002277_abnormal_respiratory_mucosa1.52318441
40MP0005310_abnormal_salivary_gland1.52131340
41MP0002009_preneoplasia1.49273765
42MP0002148_abnormal_hypersensitivity_rea1.48749177
43MP0004510_myositis1.47849548
44MP0003436_decreased_susceptibility_to1.46254530
45MP0005409_darkened_coat_color1.45225017
46MP0002419_abnormal_innate_immunity1.42465543
47MP0005464_abnormal_platelet_physiology1.34150279
48MP0000858_altered_metastatic_potential1.30885100
49MP0001853_heart_inflammation1.22116470
50MP0001545_abnormal_hematopoietic_system1.18722049
51MP0005397_hematopoietic_system_phenotyp1.18722049
52MP0009278_abnormal_bone_marrow1.17216927
53MP0010352_gastrointestinal_tract_polyps1.16419548
54MP0002019_abnormal_tumor_incidence1.13060431
55MP0000015_abnormal_ear_pigmentation1.10494587
56MP0005174_abnormal_tail_pigmentation1.09535543
57MP0002095_abnormal_skin_pigmentation1.06900128
58MP0000490_abnormal_crypts_of1.05848838
59MP0003045_fibrosis1.01757889
60MP0008469_abnormal_protein_level0.93576043
61MP0001851_eye_inflammation0.93148612
62MP0002876_abnormal_thyroid_physiology0.90039253
63MP0003448_altered_tumor_morphology0.89731022
64MP0005379_endocrine/exocrine_gland_phen0.88375532
65MP0003077_abnormal_cell_cycle0.86992587
66MP0001849_ear_inflammation0.86913925
67MP0008057_abnormal_DNA_replication0.86699585
68MP0005075_abnormal_melanosome_morpholog0.84449195
69MP0001919_abnormal_reproductive_system0.83491552
70MP0003303_peritoneal_inflammation0.83444858
71MP0000465_gastrointestinal_hemorrhage0.80992132
72MP0002693_abnormal_pancreas_physiology0.77596006
73MP0002998_abnormal_bone_remodeling0.75929927
74MP0004957_abnormal_blastocyst_morpholog0.75307603
75MP0002138_abnormal_hepatobiliary_system0.75255784
76MP0003646_muscle_fatigue0.74980598
77MP0003111_abnormal_nucleus_morphology0.72555554
78MP0001243_abnormal_dermal_layer0.71541116
79MP0003693_abnormal_embryo_hatching0.71521792
80MP0001348_abnormal_lacrimal_gland0.71044346
81MP0001346_abnormal_lacrimal_gland0.67624837
82MP0001533_abnormal_skeleton_physiology0.66420238
83MP0005166_decreased_susceptibility_to0.66327337
84MP0003878_abnormal_ear_physiology0.64529845
85MP0005377_hearing/vestibular/ear_phenot0.64529845
86MP0000477_abnormal_intestine_morphology0.62671645
87MP0003183_abnormal_peptide_metabolism0.61296093
88MP0001191_abnormal_skin_condition0.60718860
89MP0002163_abnormal_gland_morphology0.60613399
90MP0008961_abnormal_basal_metabolism0.57324075
91MP0005023_abnormal_wound_healing0.57260997
92MP0001765_abnormal_ion_homeostasis0.56808405
93MP0003191_abnormal_cellular_cholesterol0.55200560
94MP0000609_abnormal_liver_physiology0.54057910
95MP0005076_abnormal_cell_differentiation0.53596948
96MP0009763_increased_sensitivity_to0.53451465
97MP0008872_abnormal_physiological_respon0.53136234
98MP0008877_abnormal_DNA_methylation0.51604041
99MP0005390_skeleton_phenotype0.50226981
100MP0010234_abnormal_vibrissa_follicle0.50162930
101MP0003786_premature_aging0.49448343
102MP0000383_abnormal_hair_follicle0.49317439
103MP0004130_abnormal_muscle_cell0.49165558
104MP0008007_abnormal_cellular_replicative0.49081193
105MP0000313_abnormal_cell_death0.47001119
106MP0001986_abnormal_taste_sensitivity0.46837120
107MP0003795_abnormal_bone_structure0.46277678
108MP0008569_lethality_at_weaning0.46251324
109MP0008770_decreased_survivor_rate0.46050000
110MP0000604_amyloidosis0.45975688
111MP0001501_abnormal_sleep_pattern0.45617702
112MP0009765_abnormal_xenobiotic_induced0.45431664
113MP0002083_premature_death0.43310437
114MP0000920_abnormal_myelination0.43081837
115MP0005645_abnormal_hypothalamus_physiol0.42845394
116MP0002822_catalepsy0.42425837
117MP0009643_abnormal_urine_homeostasis0.41944120
118MP0009764_decreased_sensitivity_to0.40893999
119MP0001663_abnormal_digestive_system0.40644365
120MP0008058_abnormal_DNA_repair0.40506042
121MP0003252_abnormal_bile_duct0.40420013
122MP0002877_abnormal_melanocyte_morpholog0.39821086
123MP0002075_abnormal_coat/hair_pigmentati0.39716809
124MP0005451_abnormal_body_composition0.39510715
125MP0008873_increased_physiological_sensi0.39452011
126MP0000367_abnormal_coat/_hair0.37374481
127MP0004742_abnormal_vestibular_system0.36860706
128MP0003172_abnormal_lysosome_physiology0.36814435
129MP0000249_abnormal_blood_vessel0.36398141
130MP0003959_abnormal_lean_body0.35483191
131MP0000350_abnormal_cell_proliferation0.35188840
132MP0002136_abnormal_kidney_physiology0.34704219

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)8.99960010
2Combined immunodeficiency (HP:0005387)8.07499546
3Abnormality of B cell number (HP:0010975)7.62810297
4B lymphocytopenia (HP:0010976)7.62810297
5Hypoplasia of the thymus (HP:0000778)7.34952039
6Thyroiditis (HP:0100646)7.27547205
7Abnormality of T cells (HP:0002843)6.49227179
8Panhypogammaglobulinemia (HP:0003139)6.44107172
9Eosinophilia (HP:0001880)6.10148722
10Abnormality of eosinophils (HP:0001879)5.82072759
11Recurrent viral infections (HP:0004429)5.62509121
12IgG deficiency (HP:0004315)5.51046850
13Granulocytopenia (HP:0001913)5.15803445
14Elevated erythrocyte sedimentation rate (HP:0003565)5.04324575
15Recurrent fungal infections (HP:0002841)4.75033941
16Hypoproteinemia (HP:0003075)4.65348870
17Leukocytosis (HP:0001974)4.47122736
18Recurrent bronchitis (HP:0002837)4.07288298
19Increased IgM level (HP:0003496)3.96432332
20Autoimmune hemolytic anemia (HP:0001890)3.76577212
21Recurrent cutaneous fungal infections (HP:0011370)3.62807414
22Chronic mucocutaneous candidiasis (HP:0002728)3.62807414
23IgM deficiency (HP:0002850)3.39564163
24Abnormality of the fingertips (HP:0001211)3.35551226
25Chronic diarrhea (HP:0002028)3.24399017
26Abnormality of macrophages (HP:0004311)3.20806609
27Stomatitis (HP:0010280)3.20341672
28Pustule (HP:0200039)3.13739274
29Recurrent bacterial skin infections (HP:0005406)3.10729883
30Chronic otitis media (HP:0000389)2.95801046
31Myositis (HP:0100614)2.93880447
32Lymphopenia (HP:0001888)2.93058928
33Abnormality of T cell physiology (HP:0011840)2.89243298
34Aplasia/Hypoplasia of the thymus (HP:0010515)2.89107956
35Lymphoma (HP:0002665)2.87384982
36Abnormality of cells of the lymphoid lineage (HP:0012140)2.84831808
37Nasal polyposis (HP:0100582)2.82874408
38Joint swelling (HP:0001386)2.81537741
39Aplastic anemia (HP:0001915)2.78947315
40Meningitis (HP:0001287)2.68216324
41Acute hepatic failure (HP:0006554)2.60570016
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.60511081
43Chest pain (HP:0100749)2.55646035
44Hypochromic anemia (HP:0001931)2.53785233
45Eczematoid dermatitis (HP:0000976)2.45352195
46Hypergammaglobulinemia (HP:0010702)2.44479295
47Gangrene (HP:0100758)2.43525156
48Basal cell carcinoma (HP:0002671)2.41966841
49Abnormality of the nasal mucosa (HP:0000433)2.36822597
50Erythroderma (HP:0001019)2.31293681
51Abnormality of the thymus (HP:0000777)2.30947516
52Bronchitis (HP:0012387)2.28554649
53Abnormality of the pleura (HP:0002103)2.16424113
54Encephalitis (HP:0002383)2.16389496
55Recurrent otitis media (HP:0000403)2.11281220
56Keratitis (HP:0000491)2.10787864
57Cellular immunodeficiency (HP:0005374)2.07176351
58Verrucae (HP:0200043)2.06679461
59Papilloma (HP:0012740)2.06679461
60Anorexia (HP:0002039)2.06414524
61Autoimmune thrombocytopenia (HP:0001973)2.05631530
62Arterial thrombosis (HP:0004420)2.04994276
63Urticaria (HP:0001025)2.03497083
64IgA deficiency (HP:0002720)2.02299845
65Recurrent gram-negative bacterial infections (HP:0005420)2.00337887
66T lymphocytopenia (HP:0005403)10.9198825
67Abnormality of T cell number (HP:0011839)10.3938916
68Reduced subcutaneous adipose tissue (HP:0003758)1.97445755
69Stomach cancer (HP:0012126)1.93298749
70Recurrent skin infections (HP:0001581)1.92266071
71Hemoptysis (HP:0002105)1.89782113
72Vasculitis (HP:0002633)1.89637976
73Hemiplegia (HP:0002301)1.88690222
74Orchitis (HP:0100796)1.88524391
75Pancytopenia (HP:0001876)1.85030642
76Agammaglobulinemia (HP:0004432)1.84515108
77Papilledema (HP:0001085)1.82938024
78Skin rash (HP:0000988)1.80829847
79Neutropenia (HP:0001875)1.80167724
80Poikiloderma (HP:0001029)1.79381990
81Bronchiectasis (HP:0002110)1.79192051
82Episodic fever (HP:0001954)1.79090751
83Retrobulbar optic neuritis (HP:0100654)1.78209554
84Optic neuritis (HP:0100653)1.78209554
85Spontaneous hematomas (HP:0007420)1.78039998
86Recurrent sinusitis (HP:0011108)1.77635914
87Glomerulopathy (HP:0100820)1.76055918
88Bicuspid aortic valve (HP:0001647)1.73532380
89Sepsis (HP:0100806)1.73248866
90Pulmonary infiltrates (HP:0002113)1.72666943
91Polyneuropathy (HP:0001271)1.72136960
92Gingivitis (HP:0000230)1.72055270
93Entropion (HP:0000621)1.70869387
94Prostate neoplasm (HP:0100787)1.70438979
95Pulmonary fibrosis (HP:0002206)1.69255995
96Gastrointestinal infarctions (HP:0005244)1.68498398
97Petechiae (HP:0000967)1.67842434
98Gastrointestinal stroma tumor (HP:0100723)1.67284647
99Amyotrophic lateral sclerosis (HP:0007354)1.62574354
100Microcytic anemia (HP:0001935)1.59770164
101Volvulus (HP:0002580)1.56874008
102Keratoconjunctivitis sicca (HP:0001097)1.53301966
103Epistaxis (HP:0000421)1.51613592
104Cheilitis (HP:0100825)1.50988817
105Hepatitis (HP:0012115)1.50861572
106Increased IgE level (HP:0003212)1.45349389
107Chronic sinusitis (HP:0011109)1.45240753
108Gastrointestinal inflammation (HP:0004386)1.42704932
109Muscle fiber atrophy (HP:0100295)1.42696267
110Inflammation of the large intestine (HP:0002037)1.40475292
111Seborrheic dermatitis (HP:0001051)1.40050823
112Obstructive lung disease (HP:0006536)1.39660198
113Chronic obstructive pulmonary disease (HP:0006510)1.39660198
114Abnormality of the prostate (HP:0008775)1.39257284
115Abnormal platelet volume (HP:0011876)1.38957490
116Subacute progressive viral hepatitis (HP:0006572)1.37993897
117Keratoconjunctivitis (HP:0001096)1.36742503
118Recurrent abscess formation (HP:0002722)1.36704830
119Type 2 muscle fiber atrophy (HP:0003554)1.36080875
120Thrombocytosis (HP:0001894)1.35589444
121Pruritus (HP:0000989)1.35517277
122Large eyes (HP:0001090)1.35212006
123Prominent nose (HP:0000448)1.35115709
124Ureteral stenosis (HP:0000071)1.34464095
125Mediastinal lymphadenopathy (HP:0100721)1.33805680
126Pulmonary embolism (HP:0002204)1.33292597
127Prolonged bleeding time (HP:0003010)1.29457552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.84907759
2MAP4K15.53696354
3ZAP704.02841617
4TESK23.07456403
5ITK3.02448857
6FGFR42.99376150
7KDR2.55974117
8GRK62.41559986
9IKBKE2.33619419
10TAOK32.29396904
11STK102.24723705
12JAK32.24022263
13TYK22.23648034
14LCK2.08475169
15RIPK42.08023780
16SYK2.07937671
17MST41.91169347
18JAK11.89498955
19FGFR31.87054858
20CSK1.78090308
21MAP3K111.77677723
22NLK1.76160930
23NME21.56251415
24HCK1.55515354
25PDGFRB1.50334471
26TEC1.48851500
27CAMKK11.46272891
28BTK1.33081440
29TBK11.27636035
30PRKCQ1.26451831
31MAP3K71.25721427
32MAP3K101.17709727
33SIK21.14044002
34TESK11.13765057
35CDC71.11330071
36MAP3K141.03658428
37PRKCH1.02849135
38MAP3K120.99397703
39CLK10.98853167
40PKN20.98640443
41BLK0.98111937
42EEF2K0.97379732
43LRRK20.89912263
44TNK20.83821135
45CDK120.83474465
46PRPF4B0.83108780
47YES10.81157114
48MAPK70.79781093
49ADRBK20.77938492
50MAP3K130.77237207
51GRK70.77207010
52MUSK0.76525943
53LYN0.75991812
54MARK20.75379341
55JAK20.74435836
56INSR0.73884969
57BUB10.73185748
58FYN0.70049250
59KIT0.67876734
60STK40.65991684
61FGFR20.65463495
62CDK40.65161875
63MAP4K20.64255686
64TGFBR20.63959209
65MAP3K30.63621071
66TAOK20.63608564
67MARK30.62740215
68PIK3CG0.61866596
69ERN10.61569946
70BCR0.59044796
71MAP2K30.58846591
72PIM10.58661678
73SIK30.58301109
74TAOK10.56493665
75EIF2AK10.55309243
76FGFR10.55064273
77CDK60.53073826
78RPS6KA40.51820927
79TYRO30.50000009
80NUAK10.49636782
81HIPK20.48998709
82MAPK110.46365266
83NEK20.46190428
84IKBKB0.45792730
85CSF1R0.43966279
86BMPR20.43963137
87EPHA30.42265768
88MAPKAPK20.42140838
89MAPK40.42120958
90SCYL20.41501222
91FES0.41237695
92MAP2K20.39699529
93LIMK10.38009432
94TRIB30.38001709
95RPS6KB20.37260682
96ATR0.36308177
97PDK10.35257117
98EPHB10.33901898
99TLK10.32923160
100MAPK120.32898467
101MAP3K10.32567737
102CDK90.32514607
103IGF1R0.32415481
104BRD40.32123191
105CSNK1A1L0.32063870
106CHUK0.31849331
107PRKD20.31440014
108MAPK30.31353283
109SIK10.30243254
110RPS6KA50.27848312
111BCKDK0.26330046
112EIF2AK30.25759774
113IRAK40.25308965
114NTRK20.25188807
115ALK0.24979031
116AURKB0.24148271
117PRKD10.24021918
118SRC0.23295521
119ZAK0.23143858
120PTK60.22709192
121PASK0.22684132
122MELK0.21939842
123SRPK10.20767071
124MAP2K60.20367738
125CAMKK20.20348946
126PRKCD0.19492243
127MATK0.16924705
128NEK60.16331134
129FGR0.14561377
130SMG10.11570341
131VRK10.10870174
132MAPKAPK30.10644992
133WNK40.09601461
134DAPK10.09159437

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053408.14963926
2T cell receptor signaling pathway_Homo sapiens_hsa046604.61841565
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.18494507
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.14562465
5Antigen processing and presentation_Homo sapiens_hsa046122.98662301
6Hematopoietic cell lineage_Homo sapiens_hsa046402.86267222
7Measles_Homo sapiens_hsa051622.68669410
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67368829
9Non-homologous end-joining_Homo sapiens_hsa034502.66188315
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.22560461
11Allograft rejection_Homo sapiens_hsa053302.12555170
12Graft-versus-host disease_Homo sapiens_hsa053322.06780345
13Viral myocarditis_Homo sapiens_hsa054161.74504120
14Autoimmune thyroid disease_Homo sapiens_hsa053201.69547078
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.39029812
16Herpes simplex infection_Homo sapiens_hsa051681.38504684
17Osteoclast differentiation_Homo sapiens_hsa043801.37793467
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34523004
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34002992
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33586732
21Rheumatoid arthritis_Homo sapiens_hsa053231.32282545
22Leishmaniasis_Homo sapiens_hsa051401.32214226
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29963924
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23768478
25Spliceosome_Homo sapiens_hsa030401.22877469
26HTLV-I infection_Homo sapiens_hsa051661.21932243
27Ribosome_Homo sapiens_hsa030101.19184583
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17126510
29Acute myeloid leukemia_Homo sapiens_hsa052211.15561396
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.15372071
31Chemokine signaling pathway_Homo sapiens_hsa040621.14792213
32B cell receptor signaling pathway_Homo sapiens_hsa046621.14070308
33DNA replication_Homo sapiens_hsa030301.12727876
34Hepatitis B_Homo sapiens_hsa051611.11553176
35Colorectal cancer_Homo sapiens_hsa052101.05361707
36Thyroid cancer_Homo sapiens_hsa052161.01239081
37Toxoplasmosis_Homo sapiens_hsa051450.93988005
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93680803
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87849159
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85855762
41Shigellosis_Homo sapiens_hsa051310.85683952
42Mismatch repair_Homo sapiens_hsa034300.85048701
43Chronic myeloid leukemia_Homo sapiens_hsa052200.84098020
44Viral carcinogenesis_Homo sapiens_hsa052030.79865910
45Proteasome_Homo sapiens_hsa030500.78549980
46Pancreatic cancer_Homo sapiens_hsa052120.78243149
47Influenza A_Homo sapiens_hsa051640.76539465
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75691445
49African trypanosomiasis_Homo sapiens_hsa051430.73488643
50Apoptosis_Homo sapiens_hsa042100.73366137
51Asthma_Homo sapiens_hsa053100.69157375
52p53 signaling pathway_Homo sapiens_hsa041150.67828061
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66250219
54Base excision repair_Homo sapiens_hsa034100.64821756
55Type I diabetes mellitus_Homo sapiens_hsa049400.63400727
56Cell cycle_Homo sapiens_hsa041100.63110533
57RNA degradation_Homo sapiens_hsa030180.61622566
58Platelet activation_Homo sapiens_hsa046110.61081688
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60952574
60Epstein-Barr virus infection_Homo sapiens_hsa051690.60089746
61Nucleotide excision repair_Homo sapiens_hsa034200.59623430
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58112773
63VEGF signaling pathway_Homo sapiens_hsa043700.56637401
64FoxO signaling pathway_Homo sapiens_hsa040680.56624690
65Prolactin signaling pathway_Homo sapiens_hsa049170.52823245
66Linoleic acid metabolism_Homo sapiens_hsa005910.52055951
67Staphylococcus aureus infection_Homo sapiens_hsa051500.51805689
68Hepatitis C_Homo sapiens_hsa051600.50517381
69mRNA surveillance pathway_Homo sapiens_hsa030150.50143779
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49324417
71Sulfur relay system_Homo sapiens_hsa041220.49084256
72Legionellosis_Homo sapiens_hsa051340.48554764
73TNF signaling pathway_Homo sapiens_hsa046680.48539809
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47448429
75Salmonella infection_Homo sapiens_hsa051320.46200613
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46199649
77Caffeine metabolism_Homo sapiens_hsa002320.46137196
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45791824
79Endometrial cancer_Homo sapiens_hsa052130.44826488
80Non-small cell lung cancer_Homo sapiens_hsa052230.44410617
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39540271
82Phototransduction_Homo sapiens_hsa047440.37521430
83Regulation of autophagy_Homo sapiens_hsa041400.37495455
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37363839
85Endocytosis_Homo sapiens_hsa041440.37217578
86RNA transport_Homo sapiens_hsa030130.36343699
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35571931
88Adherens junction_Homo sapiens_hsa045200.35172192
89Tuberculosis_Homo sapiens_hsa051520.34747333
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34161533
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34016933
92Rap1 signaling pathway_Homo sapiens_hsa040150.33246163
93Malaria_Homo sapiens_hsa051440.32116399
94Prostate cancer_Homo sapiens_hsa052150.31789538
95Notch signaling pathway_Homo sapiens_hsa043300.30136001
96Pertussis_Homo sapiens_hsa051330.27840357
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27229005
98Small cell lung cancer_Homo sapiens_hsa052220.26557785
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23979845
100MAPK signaling pathway_Homo sapiens_hsa040100.23908670
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.22973343
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.22587847
103Choline metabolism in cancer_Homo sapiens_hsa052310.21965298
104Pyrimidine metabolism_Homo sapiens_hsa002400.21712122
105Homologous recombination_Homo sapiens_hsa034400.21045886
106Prion diseases_Homo sapiens_hsa050200.20275802
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19969993
108Pathways in cancer_Homo sapiens_hsa052000.19691317
109Phagosome_Homo sapiens_hsa041450.18443985
110Ras signaling pathway_Homo sapiens_hsa040140.17102114
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17065113
112Pentose phosphate pathway_Homo sapiens_hsa000300.15956657
113MicroRNAs in cancer_Homo sapiens_hsa052060.15241287
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15057702
115Systemic lupus erythematosus_Homo sapiens_hsa053220.14831301
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14728603
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.13346697
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.13304076
119Fanconi anemia pathway_Homo sapiens_hsa034600.12991308
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12784487
121Lysine degradation_Homo sapiens_hsa003100.12665431
122Insulin resistance_Homo sapiens_hsa049310.11477709
123RNA polymerase_Homo sapiens_hsa030200.11353915
124Arachidonic acid metabolism_Homo sapiens_hsa005900.09996077
125Nitrogen metabolism_Homo sapiens_hsa009100.06408398
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.05889303
127ABC transporters_Homo sapiens_hsa020100.05851399
128Glycerolipid metabolism_Homo sapiens_hsa005610.05217015
129Ether lipid metabolism_Homo sapiens_hsa005650.04839605
130Olfactory transduction_Homo sapiens_hsa047400.03772507

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