TRAV9-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.86739535
2negative thymic T cell selection (GO:0045060)8.70340859
3positive thymic T cell selection (GO:0045059)8.68484208
4positive regulation of gamma-delta T cell activation (GO:0046645)8.55532016
5thymic T cell selection (GO:0045061)8.10875635
6positive T cell selection (GO:0043368)7.91031762
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.87906162
8regulation of gamma-delta T cell differentiation (GO:0045586)7.64629945
9T cell selection (GO:0045058)7.52383875
10regulation of gamma-delta T cell activation (GO:0046643)6.80664810
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)6.60294465
12regulation of T cell tolerance induction (GO:0002664)6.46486120
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.43359560
14negative regulation of cell killing (GO:0031342)6.43359560
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.42032096
16response to interleukin-15 (GO:0070672)6.18025850
17regulation of isotype switching to IgG isotypes (GO:0048302)6.15630080
18leukocyte aggregation (GO:0070486)5.81357445
19T cell receptor signaling pathway (GO:0050852)5.71875563
20regulation of interleukin-2 biosynthetic process (GO:0045076)5.71846021
21cellular response to interleukin-15 (GO:0071350)5.62908374
22T cell costimulation (GO:0031295)5.50439307
23lymphocyte costimulation (GO:0031294)5.41502529
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41100376
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41100376
26positive regulation of tolerance induction (GO:0002645)5.29504775
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10051918
28interferon-gamma production (GO:0032609)5.02967942
29T cell migration (GO:0072678)4.97306126
30regulation of regulatory T cell differentiation (GO:0045589)4.90239882
31positive regulation of interleukin-2 production (GO:0032743)4.80738401
32antigen receptor-mediated signaling pathway (GO:0050851)4.80712190
33regulation of alpha-beta T cell proliferation (GO:0046640)4.80267885
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.77303101
35positive regulation of natural killer cell mediated immunity (GO:0002717)4.67648967
36positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.67648967
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.62451690
38regulation of tolerance induction (GO:0002643)4.60591052
39antigen processing and presentation of endogenous antigen (GO:0019883)4.49094380
40regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.41393738
41regulation of natural killer cell mediated immunity (GO:0002715)4.41393738
42regulation of monocyte differentiation (GO:0045655)4.38766756
43regulation of interleukin-12 biosynthetic process (GO:0045075)4.36117613
44tolerance induction (GO:0002507)4.31403082
45regulation of T cell receptor signaling pathway (GO:0050856)4.20286469
46positive regulation of humoral immune response (GO:0002922)4.17116999
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.03913755
48mast cell activation (GO:0045576)3.98231179
49activated T cell proliferation (GO:0050798)3.92758205
50regulation of type I interferon-mediated signaling pathway (GO:0060338)3.87491003
51positive regulation of immunoglobulin mediated immune response (GO:0002891)3.86292650
52positive regulation of B cell mediated immunity (GO:0002714)3.86292650
53regulation of B cell receptor signaling pathway (GO:0050855)3.81741427
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.77962800
55regulation of immunoglobulin mediated immune response (GO:0002889)3.75531296
56regulation of defense response to virus by virus (GO:0050690)3.73938366
57T cell differentiation (GO:0030217)3.71910321
58regulation of isotype switching (GO:0045191)3.64235686
59regulation of response to interferon-gamma (GO:0060330)3.61824321
60regulation of leukocyte mediated cytotoxicity (GO:0001910)3.61745000
61regulation of B cell mediated immunity (GO:0002712)3.61440814
62positive regulation of immune response to tumor cell (GO:0002839)3.60814746
63regulation of immune response to tumor cell (GO:0002837)3.60814746
64regulation of response to tumor cell (GO:0002834)3.60814746
65positive regulation of response to tumor cell (GO:0002836)3.60814746
66positive regulation of interleukin-4 production (GO:0032753)3.52739634
67T cell activation (GO:0042110)3.51237392
68positive regulation of isotype switching (GO:0045830)3.51017616
69antigen processing and presentation via MHC class Ib (GO:0002475)3.50501794
70regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.50399714
71regulation of interleukin-2 production (GO:0032663)3.46950850
72T cell homeostasis (GO:0043029)3.43383508
73negative regulation of T cell mediated immunity (GO:0002710)3.37818739
74response to type I interferon (GO:0034340)3.37347383
75positive regulation of cell killing (GO:0031343)3.32560697
76leukocyte cell-cell adhesion (GO:0007159)3.32159784
77regulation of interleukin-4 production (GO:0032673)3.31566314
78regulation of cell killing (GO:0031341)3.30983441
79natural killer cell differentiation (GO:0001779)3.30446372
80heterotypic cell-cell adhesion (GO:0034113)3.29592019
81immune response-activating cell surface receptor signaling pathway (GO:0002429)3.29541430
82type I interferon signaling pathway (GO:0060337)3.28519740
83cellular response to type I interferon (GO:0071357)3.28519740
84Peyers patch development (GO:0048541)3.25906465
85mucosal-associated lymphoid tissue development (GO:0048537)3.25906465
86positive regulation of T cell activation (GO:0050870)3.25558385
87alpha-beta T cell differentiation (GO:0046632)3.24084841
88regulation of immunoglobulin production (GO:0002637)3.23913325
89natural killer cell activation (GO:0030101)3.22358837
90alpha-beta T cell activation (GO:0046631)3.21648767
91B cell mediated immunity (GO:0019724)3.21555023
92mast cell activation involved in immune response (GO:0002279)3.19956520
93mast cell degranulation (GO:0043303)3.19956520
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17840382
95regulation of B cell differentiation (GO:0045577)3.11630402
96NIK/NF-kappaB signaling (GO:0038061)3.11615492
97negative regulation of T cell receptor signaling pathway (GO:0050860)3.09100743
98interferon-gamma-mediated signaling pathway (GO:0060333)3.08887982
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.07660525
100tumor necrosis factor-mediated signaling pathway (GO:0033209)3.00401668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.63185483
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.80928636
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.07035398
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.96693049
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.92180155
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.88670772
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.87884482
8MYC_22102868_ChIP-Seq_BL_Human3.83448781
9RUNX_20019798_ChIP-Seq_JUKART_Human3.81514100
10E2F7_22180533_ChIP-Seq_HELA_Human3.74138930
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.63485619
12MYB_26560356_Chip-Seq_TH2_Human3.39518877
13MAF_26560356_Chip-Seq_TH1_Human3.32734424
14UTX_26944678_Chip-Seq_JUKART_Human3.04765621
15NOTCH1_21737748_ChIP-Seq_TLL_Human3.02851433
16MYB_26560356_Chip-Seq_TH1_Human2.88080402
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80624248
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57260187
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.53357235
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.34977523
21GATA3_27048872_Chip-Seq_THYMUS_Human2.28205389
22MAF_26560356_Chip-Seq_TH2_Human2.27275727
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16509273
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15000904
25VDR_21846776_ChIP-Seq_THP-1_Human2.11538422
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08960472
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05210417
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.04058686
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.85004068
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78396676
31TCF7_22412390_ChIP-Seq_EML_Mouse1.74606103
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74229597
33KDM2B_26808549_Chip-Seq_DND41_Human1.73833714
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70616312
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69619411
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66067063
37SCL_19346495_ChIP-Seq_HPC-7_Human1.65182315
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64822702
39SPI1_23547873_ChIP-Seq_NB4_Human1.64026648
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61657055
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57701460
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53037740
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52639064
44VDR_24763502_ChIP-Seq_THP-1_Human1.46101335
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45825930
46SPI1_23127762_ChIP-Seq_K562_Human1.43422367
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43025747
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41158152
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.39433955
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36520358
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34576992
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.32595527
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30441930
54GATA3_26560356_Chip-Seq_TH2_Human1.30083536
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26318666
56CIITA_25753668_ChIP-Seq_RAJI_Human1.24234678
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21573961
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16239700
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12837244
60PU_27001747_Chip-Seq_BMDM_Mouse1.11698723
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07590246
62ELK3_25401928_ChIP-Seq_HUVEC_Human0.95589097
63RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94637721
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93697772
65SMAD_19615063_ChIP-ChIP_OVARY_Human0.92937482
66FOXP3_21729870_ChIP-Seq_TREG_Human0.92286303
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91553448
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89460593
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88585170
70VDR_23849224_ChIP-Seq_CD4+_Human0.87373944
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86765628
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85768527
73ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85607585
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85515716
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83750372
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83160783
77RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80570461
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78813010
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77732687
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77550437
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76979645
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76950619
83LXR_22292898_ChIP-Seq_THP-1_Human0.73549665
84ELK1_19687146_ChIP-ChIP_HELA_Human0.69516401
85SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68707292
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68236862
87E2F4_17652178_ChIP-ChIP_JURKAT_Human0.68219451
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.67878609
89MYC_18555785_ChIP-Seq_MESCs_Mouse0.66525189
90NCOR1_26117541_ChIP-Seq_K562_Human0.66386403
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65497443
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.61775410
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.61072785
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61048081
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.60422705
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.59496994
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.58864604
98XRN2_22483619_ChIP-Seq_HELA_Human0.58742501
99BCL6_27268052_Chip-Seq_Bcells_Human0.58412525
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.57664808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.12813140
2MP0005671_abnormal_response_to4.73794005
3MP0002166_altered_tumor_susceptibility3.77606196
4MP0000685_abnormal_immune_system3.60251725
5MP0003300_gastrointestinal_ulcer3.18782912
6MP0009333_abnormal_splenocyte_physiolog3.17800702
7MP0001835_abnormal_antigen_presentation3.12470530
8MP0001800_abnormal_humoral_immune3.11258785
9MP0009785_altered_susceptibility_to3.07419115
10MP0002006_tumorigenesis2.98197039
11MP0001790_abnormal_immune_system2.96497977
12MP0005387_immune_system_phenotype2.96497977
13MP0000703_abnormal_thymus_morphology2.88303352
14MP0005000_abnormal_immune_tolerance2.85402034
15MP0002398_abnormal_bone_marrow2.83800478
16MP0003724_increased_susceptibility_to2.82235524
17MP0002420_abnormal_adaptive_immunity2.82209081
18MP0002723_abnormal_immune_serum2.82166891
19MP0001819_abnormal_immune_cell2.78549684
20MP0006082_CNS_inflammation2.76830580
21MP0005025_abnormal_response_to2.55893495
22MP0003866_abnormal_defecation2.54229731
23MP0002452_abnormal_antigen_presenting2.48135291
24MP0004947_skin_inflammation2.45373709
25MP0000716_abnormal_immune_system2.44410388
26MP0002405_respiratory_system_inflammati2.43500244
27MP0002722_abnormal_immune_system2.40248669
28MP0010155_abnormal_intestine_physiology2.32552993
29MP0002396_abnormal_hematopoietic_system2.28086374
30MP0003436_decreased_susceptibility_to2.25933522
31MP0000689_abnormal_spleen_morphology2.23812757
32MP0002933_joint_inflammation2.08634697
33MP0002429_abnormal_blood_cell1.97545779
34MP0001873_stomach_inflammation1.96918759
35MP0003303_peritoneal_inflammation1.75686398
36MP0002419_abnormal_innate_immunity1.67170280
37MP0005464_abnormal_platelet_physiology1.63083788
38MP0004510_myositis1.62248717
39MP0001845_abnormal_inflammatory_respons1.62099022
40MP0002148_abnormal_hypersensitivity_rea1.59092580
41MP0004808_abnormal_hematopoietic_stem1.45990668
42MP0002009_preneoplasia1.42645775
43MP0004381_abnormal_hair_follicle1.40276199
44MP0000858_altered_metastatic_potential1.37915973
45MP0001853_heart_inflammation1.37632997
46MP0003448_altered_tumor_morphology1.36659133
47MP0000465_gastrointestinal_hemorrhage1.27218258
48MP0000490_abnormal_crypts_of1.26505731
49MP0008469_abnormal_protein_level1.12996426
50MP0005310_abnormal_salivary_gland1.11836992
51MP0001851_eye_inflammation1.01145393
52MP0008057_abnormal_DNA_replication1.00997125
53MP0001348_abnormal_lacrimal_gland0.97311725
54MP0003045_fibrosis0.96652778
55MP0001533_abnormal_skeleton_physiology0.95122323
56MP0002998_abnormal_bone_remodeling0.92554968
57MP0002019_abnormal_tumor_incidence0.91251312
58MP0005023_abnormal_wound_healing0.84002952
59MP0002138_abnormal_hepatobiliary_system0.83612431
60MP0005397_hematopoietic_system_phenotyp0.81097338
61MP0001545_abnormal_hematopoietic_system0.81097338
62MP0003693_abnormal_embryo_hatching0.76184779
63MP0005076_abnormal_cell_differentiation0.75041269
64MP0008961_abnormal_basal_metabolism0.71816820
65MP0002163_abnormal_gland_morphology0.70919832
66MP0000477_abnormal_intestine_morphology0.70022601
67MP0000604_amyloidosis0.70017332
68MP0009763_increased_sensitivity_to0.67038564
69MP0005075_abnormal_melanosome_morpholog0.66538747
70MP0000609_abnormal_liver_physiology0.65784786
71MP0010352_gastrointestinal_tract_polyps0.65541295
72MP0003795_abnormal_bone_structure0.65430118
73MP0002822_catalepsy0.61218108
74MP0003077_abnormal_cell_cycle0.61003189
75MP0001191_abnormal_skin_condition0.59347746
76MP0001243_abnormal_dermal_layer0.51619887
77MP0008569_lethality_at_weaning0.51141318
78MP0001663_abnormal_digestive_system0.50990639
79MP0010094_abnormal_chromosome_stability0.50700487
80MP0010234_abnormal_vibrissa_follicle0.50169172
81MP0001216_abnormal_epidermal_layer0.49565911
82MP0004742_abnormal_vestibular_system0.49489774
83MP0009765_abnormal_xenobiotic_induced0.48682114
84MP0003453_abnormal_keratinocyte_physiol0.45754864
85MP0002136_abnormal_kidney_physiology0.45727747
86MP0002693_abnormal_pancreas_physiology0.44608967
87MP0004185_abnormal_adipocyte_glucose0.41574391
88MP0002132_abnormal_respiratory_system0.39365716
89MP0000367_abnormal_coat/_hair0.38725220
90MP0000313_abnormal_cell_death0.37877399
91MP0003787_abnormal_imprinting0.37703174
92MP0008873_increased_physiological_sensi0.36962548
93MP0002083_premature_death0.36537978
94MP0005451_abnormal_body_composition0.36207794
95MP0000598_abnormal_liver_morphology0.35675300
96MP0003959_abnormal_lean_body0.35620810
97MP0004957_abnormal_blastocyst_morpholog0.35516717
98MP0003111_abnormal_nucleus_morphology0.34006013
99MP0001881_abnormal_mammary_gland0.33987259
100MP0009764_decreased_sensitivity_to0.32893555

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)7.86660208
2T lymphocytopenia (HP:0005403)7.81244116
3Elevated erythrocyte sedimentation rate (HP:0003565)7.00391576
4Stomatitis (HP:0010280)5.91494666
5Severe combined immunodeficiency (HP:0004430)5.74664312
6Abnormality of T cells (HP:0002843)5.56957597
7Combined immunodeficiency (HP:0005387)5.41278706
8Autoimmune hemolytic anemia (HP:0001890)4.80034288
9IgG deficiency (HP:0004315)4.65535192
10Abnormality of B cell number (HP:0010975)4.65468927
11B lymphocytopenia (HP:0010976)4.65468927
12Increased IgM level (HP:0003496)4.50626505
13Panhypogammaglobulinemia (HP:0003139)4.47626872
14Recurrent fungal infections (HP:0002841)4.44204160
15Lymphopenia (HP:0001888)4.37839313
16Abnormality of cells of the lymphoid lineage (HP:0012140)4.36534057
17Recurrent bronchitis (HP:0002837)4.31256689
18Recurrent viral infections (HP:0004429)4.25251392
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.93324281
20IgM deficiency (HP:0002850)3.92492162
21Chronic mucocutaneous candidiasis (HP:0002728)3.85866308
22Recurrent cutaneous fungal infections (HP:0011370)3.85866308
23Eosinophilia (HP:0001880)3.83166662
24Abnormality of eosinophils (HP:0001879)3.78683648
25Eczematoid dermatitis (HP:0000976)3.77414714
26Leukocytosis (HP:0001974)3.73085871
27Abnormality of T cell physiology (HP:0011840)3.72751830
28Abnormality of the fingertips (HP:0001211)3.68283093
29Joint swelling (HP:0001386)3.61967183
30Basal cell carcinoma (HP:0002671)3.54813562
31Myositis (HP:0100614)3.54551795
32Chronic otitis media (HP:0000389)3.52660050
33Chronic diarrhea (HP:0002028)3.50763798
34Pustule (HP:0200039)3.42123522
35Autoimmune thrombocytopenia (HP:0001973)3.32998907
36Nasal polyposis (HP:0100582)3.26653256
37Granulocytopenia (HP:0001913)3.24125335
38Thrombocytosis (HP:0001894)3.16474835
39Thyroiditis (HP:0100646)2.92322000
40Abnormality of DNA repair (HP:0003254)2.90702989
41Hypergammaglobulinemia (HP:0010702)2.90326011
42Recurrent abscess formation (HP:0002722)2.89528413
43Recurrent otitis media (HP:0000403)2.83370625
44IgA deficiency (HP:0002720)2.81971370
45Abnormality of the nasal mucosa (HP:0000433)2.74350083
46Poikiloderma (HP:0001029)2.70159982
47Entropion (HP:0000621)2.69210229
48Hemoptysis (HP:0002105)2.69051276
49Hypoplasia of the thymus (HP:0000778)2.64315843
50Lymphoma (HP:0002665)2.62739391
51Inflammation of the large intestine (HP:0002037)2.60248549
52Vasculitis (HP:0002633)2.59042151
53Chronic obstructive pulmonary disease (HP:0006510)2.51887230
54Obstructive lung disease (HP:0006536)2.51887230
55Gastrointestinal inflammation (HP:0004386)2.45388259
56Retrobulbar optic neuritis (HP:0100654)2.41858272
57Optic neuritis (HP:0100653)2.41858272
58Petechiae (HP:0000967)2.41591269
59Recurrent sinusitis (HP:0011108)2.38894610
60Cheilitis (HP:0100825)2.36822502
61Meningitis (HP:0001287)2.34833606
62Spontaneous hematomas (HP:0007420)2.32936480
63Periodontitis (HP:0000704)2.31732467
64Bronchitis (HP:0012387)2.31682253
65Gastrointestinal infarctions (HP:0005244)2.31412952
66Pulmonary infiltrates (HP:0002113)2.27171700
67Recurrent skin infections (HP:0001581)2.13732907
68Encephalitis (HP:0002383)2.13404592
69Abnormal platelet volume (HP:0011876)2.13133049
70Hypochromic anemia (HP:0001931)2.10207635
71Hypoproteinemia (HP:0003075)2.06891240
72Mediastinal lymphadenopathy (HP:0100721)2.02931110
73Increased IgE level (HP:0003212)2.01603061
74Orchitis (HP:0100796)2.01022012
75Colitis (HP:0002583)2.00403572
76Aplasia/Hypoplasia of the thymus (HP:0010515)1.98576112
77Increased density of long bones (HP:0006392)1.98094888
78Epistaxis (HP:0000421)1.96615207
79Gingivitis (HP:0000230)1.94746324
80Chest pain (HP:0100749)1.94730514
81Prolonged bleeding time (HP:0003010)1.92193031
82Arterial thrombosis (HP:0004420)1.89439124
83Amaurosis fugax (HP:0100576)1.89257895
84Hepatitis (HP:0012115)1.86193270
85Keratoconjunctivitis sicca (HP:0001097)1.85133634
86Recurrent gram-negative bacterial infections (HP:0005420)1.82294755
87Pulmonary embolism (HP:0002204)1.81182872
88Prominent nose (HP:0000448)1.81017491
89Ureteral stenosis (HP:0000071)1.80262828
90Abnormality of the endocardium (HP:0004306)1.79844849
91Reticulocytopenia (HP:0001896)1.78798286
92Abnormality of the prostate (HP:0008775)1.74757950
93Chronic sinusitis (HP:0011109)1.74639304
94Purpura (HP:0000979)1.73409454
95Bronchiectasis (HP:0002110)1.73250077
96Abnormal number of incisors (HP:0011064)1.72428791
97Agammaglobulinemia (HP:0004432)1.71883574
98Microcytic anemia (HP:0001935)1.71626142
99Frequent falls (HP:0002359)1.71302066
100Verrucae (HP:0200043)1.70614517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.17287355
2MAP4K15.55413728
3IKBKE3.93509846
4FGFR43.92959092
5ITK3.22304683
6ZAP703.19567408
7JAK33.14643396
8TYK23.04715442
9TBK12.69409239
10FGFR32.32440767
11MAP3K142.27006563
12JAK12.26645875
13STK102.21952558
14LCK2.11130341
15TEC1.90052552
16MAP3K131.75777573
17NLK1.62964596
18PRKCH1.62705327
19GRK61.58140055
20PKN21.56953208
21TAOK11.55258553
22HCK1.53396922
23EEF2K1.52762473
24MST41.42518350
25SYK1.34409117
26CSK1.29777239
27KIT1.25096538
28PRKCQ1.23175580
29BTK1.16212280
30IKBKB1.09821879
31KDR1.05269845
32LRRK21.02841211
33PASK0.99520725
34JAK20.99472869
35MAP3K110.99239050
36NME20.98873433
37MAP3K70.95435337
38MAP2K30.90820614
39TAOK20.89025717
40MAP3K100.86088763
41TYRO30.81976145
42MAP3K120.81968727
43TNIK0.81304772
44CHUK0.79740983
45TLK10.73572851
46FGFR10.71472688
47TRIB30.70499690
48MARK30.68007714
49FES0.65536842
50TGFBR10.64540259
51CDK120.64092749
52LYN0.62979729
53FGFR20.62091235
54PDGFRB0.59878395
55SIK20.59774639
56PDK10.58330554
57RPS6KA40.56777525
58PIM10.55282804
59TNK20.54086794
60MAPK110.53958063
61CLK10.53088525
62MAP3K30.52102444
63INSR0.50770299
64CDK90.49084157
65FLT30.49077429
66FYN0.47456099
67NTRK20.46655026
68IGF1R0.44641830
69ALK0.42895861
70MARK20.42398467
71MAP3K80.40541777
72TGFBR20.40009790
73BLK0.39616675
74ACVR1B0.38181083
75EPHB10.36370745
76PTK60.36324012
77MAP2K60.33881261
78HIPK20.33497840
79TESK20.33321244
80CSF1R0.32294910
81MELK0.31513837
82EGFR0.31185145
83RPS6KA50.30640116
84CDK40.30033114
85DMPK0.29619666
86MAPK70.28485353
87ROCK20.28011609
88TTN0.27003408
89MAPK30.26122458
90DYRK1B0.23499069
91MAPK120.19474551
92CDK60.18916085
93BRD40.17775653
94PIM20.16880018
95SRC0.16619713
96EPHA30.16574487
97PRKD20.16382235
98RET0.16054877
99ABL10.15504806
100ATR0.15494002

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.44951537
2T cell receptor signaling pathway_Homo sapiens_hsa046604.59798787
3Measles_Homo sapiens_hsa051623.33095312
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.85677167
5Allograft rejection_Homo sapiens_hsa053302.84778187
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.84153716
7Hematopoietic cell lineage_Homo sapiens_hsa046402.70944182
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.61837618
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.56192105
10Autoimmune thyroid disease_Homo sapiens_hsa053202.30116962
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25668659
12Graft-versus-host disease_Homo sapiens_hsa053322.24256253
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23609936
14Viral myocarditis_Homo sapiens_hsa054162.12869495
15Osteoclast differentiation_Homo sapiens_hsa043801.87800481
16Antigen processing and presentation_Homo sapiens_hsa046121.81725821
17Leishmaniasis_Homo sapiens_hsa051401.76333639
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68258352
19Hepatitis B_Homo sapiens_hsa051611.63244747
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.62854003
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61218215
22Herpes simplex infection_Homo sapiens_hsa051681.59448508
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54021014
24Ribosome_Homo sapiens_hsa030101.46364075
25B cell receptor signaling pathway_Homo sapiens_hsa046621.45902818
26Type I diabetes mellitus_Homo sapiens_hsa049401.40267137
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.33688399
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29717715
29Chemokine signaling pathway_Homo sapiens_hsa040621.29239743
30Acute myeloid leukemia_Homo sapiens_hsa052211.28938308
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25007052
32HTLV-I infection_Homo sapiens_hsa051661.24587959
33Toxoplasmosis_Homo sapiens_hsa051451.23922560
34Influenza A_Homo sapiens_hsa051641.17579458
35Shigellosis_Homo sapiens_hsa051311.16613585
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13544991
37Asthma_Homo sapiens_hsa053101.10390116
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04405918
39Pancreatic cancer_Homo sapiens_hsa052120.95004669
40Staphylococcus aureus infection_Homo sapiens_hsa051500.94207188
41Hepatitis C_Homo sapiens_hsa051600.93142468
42Prolactin signaling pathway_Homo sapiens_hsa049170.92100224
43Epstein-Barr virus infection_Homo sapiens_hsa051690.90475187
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90150326
45TNF signaling pathway_Homo sapiens_hsa046680.88314446
46Spliceosome_Homo sapiens_hsa030400.84860674
47Chronic myeloid leukemia_Homo sapiens_hsa052200.82530906
48Viral carcinogenesis_Homo sapiens_hsa052030.81991602
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79916514
50Apoptosis_Homo sapiens_hsa042100.79556613
51Colorectal cancer_Homo sapiens_hsa052100.76374370
52VEGF signaling pathway_Homo sapiens_hsa043700.76056218
53Platelet activation_Homo sapiens_hsa046110.74066554
54Legionellosis_Homo sapiens_hsa051340.72244472
55Malaria_Homo sapiens_hsa051440.69149625
56p53 signaling pathway_Homo sapiens_hsa041150.68820987
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.66294445
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63587630
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59703749
60Tuberculosis_Homo sapiens_hsa051520.57789540
61RNA degradation_Homo sapiens_hsa030180.52239291
62Small cell lung cancer_Homo sapiens_hsa052220.51464083
63Nucleotide excision repair_Homo sapiens_hsa034200.49514353
64One carbon pool by folate_Homo sapiens_hsa006700.43719443
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42911007
66Rheumatoid arthritis_Homo sapiens_hsa053230.40711095
67Pertussis_Homo sapiens_hsa051330.38701903
68Thyroid cancer_Homo sapiens_hsa052160.36974246
69Rap1 signaling pathway_Homo sapiens_hsa040150.36618629
70Notch signaling pathway_Homo sapiens_hsa043300.36572141
71Endocytosis_Homo sapiens_hsa041440.36476544
72Salmonella infection_Homo sapiens_hsa051320.36435824
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36380509
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35141395
75MAPK signaling pathway_Homo sapiens_hsa040100.35118217
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34251084
77Non-homologous end-joining_Homo sapiens_hsa034500.34225014
78mRNA surveillance pathway_Homo sapiens_hsa030150.33616353
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32059447
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.30771007
81DNA replication_Homo sapiens_hsa030300.29729594
82Choline metabolism in cancer_Homo sapiens_hsa052310.27802811
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26086065
84Non-small cell lung cancer_Homo sapiens_hsa052230.25122615
85Prostate cancer_Homo sapiens_hsa052150.23835609
86Sulfur relay system_Homo sapiens_hsa041220.23193760
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22321832
88RNA transport_Homo sapiens_hsa030130.22237023
89Lysine degradation_Homo sapiens_hsa003100.21293973
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.20993642
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.20805516
92Pathways in cancer_Homo sapiens_hsa052000.19100202
93Insulin resistance_Homo sapiens_hsa049310.18386612
94FoxO signaling pathway_Homo sapiens_hsa040680.15370498
95HIF-1 signaling pathway_Homo sapiens_hsa040660.14960065
96Mismatch repair_Homo sapiens_hsa034300.14104982
97Fanconi anemia pathway_Homo sapiens_hsa034600.14092384
98Inositol phosphate metabolism_Homo sapiens_hsa005620.13583130
99Adherens junction_Homo sapiens_hsa045200.10041145
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09843884

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