TRAV23DV6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.50984715
2negative T cell selection (GO:0043383)6.63428580
3negative thymic T cell selection (GO:0045060)6.57601198
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.43550436
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.17397612
6negative regulation of cell killing (GO:0031342)6.17397612
7tolerance induction (GO:0002507)6.09589567
8positive regulation of gamma-delta T cell activation (GO:0046645)5.97108951
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.94665104
10regulation of T cell tolerance induction (GO:0002664)5.47912505
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.45597557
12regulation of regulatory T cell differentiation (GO:0045589)5.38672841
13thymic T cell selection (GO:0045061)5.35382601
14antigen processing and presentation of endogenous antigen (GO:0019883)5.34356470
15positive T cell selection (GO:0043368)5.30053902
16regulation of B cell receptor signaling pathway (GO:0050855)5.27679578
17T cell selection (GO:0045058)5.10963904
18positive regulation of tolerance induction (GO:0002645)5.07034282
19positive thymic T cell selection (GO:0045059)5.04113612
20positive regulation of humoral immune response (GO:0002922)5.03881485
21response to interleukin-15 (GO:0070672)5.03544431
22positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.03455297
23cellular response to interleukin-15 (GO:0071350)5.01699383
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.88711598
25leukocyte aggregation (GO:0070486)4.75198398
26mast cell activation (GO:0045576)4.70403915
27regulation of gamma-delta T cell differentiation (GO:0045586)4.69509641
28regulation of tolerance induction (GO:0002643)4.68084528
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.67482992
30regulation of isotype switching to IgG isotypes (GO:0048302)4.43653490
31activated T cell proliferation (GO:0050798)4.41271287
32regulation of gamma-delta T cell activation (GO:0046643)4.37989839
33regulation of chronic inflammatory response (GO:0002676)4.34544435
34lymph node development (GO:0048535)4.30756620
35T cell migration (GO:0072678)4.24182712
36negative regulation of lymphocyte mediated immunity (GO:0002707)4.19493464
37negative regulation of T cell mediated immunity (GO:0002710)4.15444355
38regulation of B cell differentiation (GO:0045577)3.99306166
39positive regulation of B cell differentiation (GO:0045579)3.92135231
40regulation of interleukin-2 biosynthetic process (GO:0045076)3.89633139
41regulation of alpha-beta T cell proliferation (GO:0046640)3.86761794
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.84080077
43T cell receptor signaling pathway (GO:0050852)3.82472128
44positive regulation of granulocyte differentiation (GO:0030854)3.80861095
45regulation of T cell mediated cytotoxicity (GO:0001914)3.75839477
46purine deoxyribonucleotide catabolic process (GO:0009155)3.75174765
47T cell homeostasis (GO:0043029)3.64326295
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.61692613
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.58564788
50antigen receptor-mediated signaling pathway (GO:0050851)3.55490857
51alpha-beta T cell differentiation (GO:0046632)3.48268368
52regulation of ARF protein signal transduction (GO:0032012)3.48175141
53negative regulation of leukocyte mediated immunity (GO:0002704)3.42071735
54negative regulation of immunoglobulin mediated immune response (GO:0002890)3.41670554
55negative regulation of B cell mediated immunity (GO:0002713)3.41670554
56interferon-gamma production (GO:0032609)3.41542915
57mast cell activation involved in immune response (GO:0002279)3.39895852
58mast cell degranulation (GO:0043303)3.39895852
59B cell receptor signaling pathway (GO:0050853)3.36937764
60positive regulation of T cell differentiation in thymus (GO:0033089)3.36678663
61antigen processing and presentation via MHC class Ib (GO:0002475)3.35601882
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.29528792
63response to type I interferon (GO:0034340)3.27725810
64mucosal-associated lymphoid tissue development (GO:0048537)3.27570290
65Peyers patch development (GO:0048541)3.27570290
66regulation of natural killer cell mediated immunity (GO:0002715)3.27373861
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.27373861
68type I interferon signaling pathway (GO:0060337)3.26395730
69cellular response to type I interferon (GO:0071357)3.26395730
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.25993827
71regulation of interleukin-1 beta secretion (GO:0050706)3.23430634
72negative regulation of calcium ion transport into cytosol (GO:0010523)3.21830701
73positive regulation of immunoglobulin mediated immune response (GO:0002891)3.20292752
74positive regulation of B cell mediated immunity (GO:0002714)3.20292752
75regulation of leukocyte mediated cytotoxicity (GO:0001910)3.17306119
76myeloid dendritic cell differentiation (GO:0043011)3.16445802
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14157603
78positive regulation by organism of defense response of other organism involved in symbiotic interact3.14157603
79modulation by symbiont of host immune response (GO:0052553)3.14157603
80positive regulation by symbiont of host defense response (GO:0052509)3.14157603
81modulation by symbiont of host defense response (GO:0052031)3.14157603
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14157603
83alpha-beta T cell activation (GO:0046631)3.11841849
84myeloid leukocyte mediated immunity (GO:0002444)3.09120001
85negative regulation of interleukin-12 production (GO:0032695)3.08397844
86regulation of immunoglobulin mediated immune response (GO:0002889)3.07032464
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04064086
88regulation of B cell mediated immunity (GO:0002712)3.02240286
89T cell costimulation (GO:0031295)3.01836689
90detection of bacterium (GO:0016045)3.01493318
91T cell differentiation (GO:0030217)3.00574195
92detection of other organism (GO:0098543)2.99192050
93regulation of isotype switching (GO:0045191)2.98457497
94lymphocyte costimulation (GO:0031294)2.98013702
95positive regulation of T cell mediated immunity (GO:0002711)2.94278998
96lymphocyte migration (GO:0072676)2.93732783
97myeloid dendritic cell activation (GO:0001773)2.93641003
98positive regulation of cell killing (GO:0031343)2.90471809
99T cell activation (GO:0042110)2.88963322
100lymphocyte homeostasis (GO:0002260)2.88096152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.92084326
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.53516882
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.41011896
4RUNX_20019798_ChIP-Seq_JUKART_Human3.89660297
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.84697830
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.73700042
7MYB_26560356_Chip-Seq_TH2_Human3.42743581
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40040067
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.30923489
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16209622
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10334392
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.91926291
13MYB_26560356_Chip-Seq_TH1_Human2.91278158
14MAF_26560356_Chip-Seq_TH1_Human2.86701315
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.85900949
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.80342048
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74519885
18UTX_26944678_Chip-Seq_JUKART_Human2.65584167
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59850809
20MAF_26560356_Chip-Seq_TH2_Human2.49459298
21MYC_22102868_ChIP-Seq_BL_Human2.41222465
22GATA3_27048872_Chip-Seq_THYMUS_Human2.38930043
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37509484
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.33945612
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32454475
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20244459
27SPI1_23547873_ChIP-Seq_NB4_Human2.17258018
28SCL_19346495_ChIP-Seq_HPC-7_Human2.16980092
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96687732
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.95604636
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88917446
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88483600
33SPI1_23127762_ChIP-Seq_K562_Human1.82273817
34VDR_24763502_ChIP-Seq_THP-1_Human1.79052255
35GATA3_26560356_Chip-Seq_TH2_Human1.77340666
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71875473
37VDR_21846776_ChIP-Seq_THP-1_Human1.70888204
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.70616748
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.69482994
40AR_21572438_ChIP-Seq_LNCaP_Human1.68852524
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66357861
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64865377
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62570480
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61866549
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59398902
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59064970
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58148138
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48432248
49TCF7_22412390_ChIP-Seq_EML_Mouse1.47351085
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33137914
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31229577
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29420716
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27558625
54KDM2B_26808549_Chip-Seq_DND41_Human1.27190054
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24349971
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.21236351
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20245089
58PU_27001747_Chip-Seq_BMDM_Mouse1.19612451
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19510302
60VDR_24787735_ChIP-Seq_THP-1_Human1.15847237
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15382249
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13256040
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11138417
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08595530
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08335627
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07298627
67CIITA_25753668_ChIP-Seq_RAJI_Human1.06817025
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06814693
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05520834
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.04946062
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03057656
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99563750
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98317397
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97784314
75VDR_23849224_ChIP-Seq_CD4+_Human0.97759318
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94859063
77SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.94170310
78FOXP3_21729870_ChIP-Seq_TREG_Human0.93866100
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93022493
80CTCF_26484167_Chip-Seq_Bcells_Mouse0.88743980
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87249732
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86666521
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85748469
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83292075
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82559126
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81911799
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81117702
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79930170
89BCL6_27268052_Chip-Seq_Bcells_Human0.79862592
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.79302633
91GATA3_26560356_Chip-Seq_TH1_Human0.79147775
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79042878
93BCOR_27268052_Chip-Seq_Bcells_Human0.77387504
94CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77280192
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76684001
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76492324
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.75533597
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75352480
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74976941
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.74968895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.52877005
2MP0003436_decreased_susceptibility_to4.33521715
3MP0005671_abnormal_response_to4.16877424
4MP0001800_abnormal_humoral_immune3.48758074
5MP0001835_abnormal_antigen_presentation3.37037365
6MP0000685_abnormal_immune_system3.30874351
7MP0005000_abnormal_immune_tolerance3.13269114
8MP0009785_altered_susceptibility_to3.11256458
9MP0009333_abnormal_splenocyte_physiolog2.97333151
10MP0003724_increased_susceptibility_to2.82677894
11MP0001873_stomach_inflammation2.79126790
12MP0002420_abnormal_adaptive_immunity2.72578250
13MP0005257_abnormal_intraocular_pressure2.70002574
14MP0002723_abnormal_immune_serum2.68736628
15MP0001819_abnormal_immune_cell2.66370145
16MP0005025_abnormal_response_to2.62937601
17MP0002405_respiratory_system_inflammati2.59078917
18MP0000703_abnormal_thymus_morphology2.56462618
19MP0002452_abnormal_antigen_presenting2.54854019
20MP0005387_immune_system_phenotype2.52865259
21MP0001790_abnormal_immune_system2.52865259
22MP0002398_abnormal_bone_marrow2.40974641
23MP0002419_abnormal_innate_immunity2.38025455
24MP0003866_abnormal_defecation2.36631823
25MP0000716_abnormal_immune_system2.27551016
26MP0003300_gastrointestinal_ulcer2.25829820
27MP0002396_abnormal_hematopoietic_system2.10698815
28MP0002722_abnormal_immune_system2.05994827
29MP0000689_abnormal_spleen_morphology2.03735225
30MP0003303_peritoneal_inflammation2.02004675
31MP0010155_abnormal_intestine_physiology2.01808522
32MP0001853_heart_inflammation1.97712219
33MP0002148_abnormal_hypersensitivity_rea1.92243215
34MP0005310_abnormal_salivary_gland1.91727322
35MP0004947_skin_inflammation1.80941582
36MP0001533_abnormal_skeleton_physiology1.75907419
37MP0006082_CNS_inflammation1.75627216
38MP0001845_abnormal_inflammatory_respons1.74496960
39MP0004381_abnormal_hair_follicle1.74381652
40MP0002429_abnormal_blood_cell1.73263494
41MP0001851_eye_inflammation1.60492022
42MP0001348_abnormal_lacrimal_gland1.60180921
43MP0002277_abnormal_respiratory_mucosa1.59317376
44MP0006054_spinal_hemorrhage1.54151201
45MP0000465_gastrointestinal_hemorrhage1.53747705
46MP0002163_abnormal_gland_morphology1.52984948
47MP0002166_altered_tumor_susceptibility1.48251839
48MP0008872_abnormal_physiological_respon1.43983247
49MP0009764_decreased_sensitivity_to1.38804513
50MP0008469_abnormal_protein_level1.35726347
51MP0002933_joint_inflammation1.32944833
52MP0001663_abnormal_digestive_system1.28240188
53MP0005464_abnormal_platelet_physiology1.25990843
54MP0003191_abnormal_cellular_cholesterol1.21059603
55MP0003183_abnormal_peptide_metabolism1.17254240
56MP0004883_abnormal_blood_vessel1.07307033
57MP0000858_altered_metastatic_potential1.06494543
58MP0001501_abnormal_sleep_pattern1.04009243
59MP0002998_abnormal_bone_remodeling0.94964420
60MP0002006_tumorigenesis0.94595343
61MP0005075_abnormal_melanosome_morpholog0.90978420
62MP0002138_abnormal_hepatobiliary_system0.89607497
63MP0006035_abnormal_mitochondrial_morpho0.87456144
64MP0003828_pulmonary_edema0.86969043
65MP0002019_abnormal_tumor_incidence0.86718300
66MP0009763_increased_sensitivity_to0.86322153
67MP0002132_abnormal_respiratory_system0.82847493
68MP0002693_abnormal_pancreas_physiology0.80754235
69MP0001919_abnormal_reproductive_system0.77655821
70MP0008961_abnormal_basal_metabolism0.76119197
71MP0000490_abnormal_crypts_of0.74322867
72MP0005381_digestive/alimentary_phenotyp0.73907806
73MP0005390_skeleton_phenotype0.73045294
74MP0002928_abnormal_bile_duct0.72794526
75MP0004510_myositis0.71148952
76MP0005379_endocrine/exocrine_gland_phen0.69260360
77MP0009278_abnormal_bone_marrow0.65243369
78MP0009765_abnormal_xenobiotic_induced0.62222073
79MP0000249_abnormal_blood_vessel0.58898389
80MP0003279_aneurysm0.58135147
81MP0003448_altered_tumor_morphology0.57681528
82MP0004808_abnormal_hematopoietic_stem0.56358273
83MP0002254_reproductive_system_inflammat0.55720167
84MP0004742_abnormal_vestibular_system0.55675901
85MP0006036_abnormal_mitochondrial_physio0.55310753
86MP0008004_abnormal_stomach_pH0.54878528
87MP0003795_abnormal_bone_structure0.53705702
88MP0003045_fibrosis0.53425710
89MP0004130_abnormal_muscle_cell0.53248618
90MP0004142_abnormal_muscle_tone0.51572305
91MP0005166_decreased_susceptibility_to0.50512071
92MP0001986_abnormal_taste_sensitivity0.47849958
93MP0001346_abnormal_lacrimal_gland0.46341337
94MP0005448_abnormal_energy_balance0.45565974
95MP0008569_lethality_at_weaning0.44308624
96MP0001765_abnormal_ion_homeostasis0.44231172
97MP0000609_abnormal_liver_physiology0.43919916
98MP0005164_abnormal_response_to0.42640306
99MP0004885_abnormal_endolymph0.42029493
100MP0005451_abnormal_body_composition0.41004837

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)8.21497565
2Autoimmune hemolytic anemia (HP:0001890)7.22867290
3Abnormal delayed hypersensitivity skin test (HP:0002963)6.52413443
4Abnormality of T cell number (HP:0011839)6.43009065
5Increased IgM level (HP:0003496)6.03738039
6Abnormality of B cell number (HP:0010975)5.86043245
7Autoimmune thrombocytopenia (HP:0001973)5.84545490
8Eosinophilia (HP:0001880)5.25769783
9Elevated erythrocyte sedimentation rate (HP:0003565)5.07004556
10Granulocytopenia (HP:0001913)4.85361575
11T lymphocytopenia (HP:0005403)4.81766968
12Stomatitis (HP:0010280)4.72493697
13Abnormality of eosinophils (HP:0001879)4.59213940
14Hypochromic anemia (HP:0001931)4.57712298
15Eczematoid dermatitis (HP:0000976)4.48626342
16Abnormality of T cells (HP:0002843)4.44801065
17Myositis (HP:0100614)4.17222072
18Leukocytosis (HP:0001974)4.10608967
19Abnormality of T cell physiology (HP:0011840)3.94821822
20Optic neuritis (HP:0100653)3.78378412
21Retrobulbar optic neuritis (HP:0100654)3.78378412
22Vasculitis (HP:0002633)3.72119284
23IgG deficiency (HP:0004315)3.68210952
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.67818901
25Orchitis (HP:0100796)3.65672381
26Recurrent bacterial skin infections (HP:0005406)3.43500999
27IgM deficiency (HP:0002850)3.42618428
28Recurrent fungal infections (HP:0002841)3.40517687
29Recurrent abscess formation (HP:0002722)3.33303588
30Congenital stationary night blindness (HP:0007642)3.32999947
31Severe combined immunodeficiency (HP:0004430)3.27978670
32Abnormality of macrophages (HP:0004311)3.23901644
33Pustule (HP:0200039)3.18915490
34Gastrointestinal infarctions (HP:0005244)3.17135594
35Encephalitis (HP:0002383)3.06902134
36Hypergammaglobulinemia (HP:0010702)3.01392429
37Meningitis (HP:0001287)3.00724033
38Colon cancer (HP:0003003)2.97747536
39Lymphopenia (HP:0001888)2.93887953
40Urticaria (HP:0001025)2.93619700
41Panhypogammaglobulinemia (HP:0003139)2.90902384
42Chronic diarrhea (HP:0002028)2.90585837
43Recurrent bronchitis (HP:0002837)2.89155405
44Spontaneous hematomas (HP:0007420)2.87950504
45Chronic mucocutaneous candidiasis (HP:0002728)2.87878839
46Recurrent cutaneous fungal infections (HP:0011370)2.87878839
47Impaired proprioception (HP:0010831)2.82219075
48Keratoconjunctivitis sicca (HP:0001097)2.78993815
49Chronic obstructive pulmonary disease (HP:0006510)2.78326004
50Obstructive lung disease (HP:0006536)2.78326004
51Mediastinal lymphadenopathy (HP:0100721)2.73540124
52Keratoconjunctivitis (HP:0001096)2.73447720
53Lymphoma (HP:0002665)2.72108436
54Recurrent gram-negative bacterial infections (HP:0005420)2.61878727
55Recurrent skin infections (HP:0001581)2.58758101
56Increased IgE level (HP:0003212)2.55989600
57Hypochromic microcytic anemia (HP:0004840)2.54280862
58Combined immunodeficiency (HP:0005387)2.53915984
59Recurrent viral infections (HP:0004429)2.53386929
60Oral leukoplakia (HP:0002745)2.47746697
61Pulmonary infiltrates (HP:0002113)2.47427355
62Amyloidosis (HP:0011034)2.45573962
63Papilledema (HP:0001085)2.43028358
64Chest pain (HP:0100749)2.41202827
65Aplastic anemia (HP:0001915)2.37699375
66Renal cortical cysts (HP:0000803)2.33752908
67Microcytic anemia (HP:0001935)2.22445544
68Inflammation of the large intestine (HP:0002037)2.21133620
69Urethral obstruction (HP:0000796)2.18515353
70Prolonged bleeding time (HP:0003010)2.16093667
71Gastrointestinal inflammation (HP:0004386)2.12364064
72Thyroiditis (HP:0100646)2.12353721
73Anorexia (HP:0002039)2.11491181
74Verrucae (HP:0200043)2.10997360
75Papilloma (HP:0012740)2.10997360
76Hemoptysis (HP:0002105)2.08259595
77Metabolic alkalosis (HP:0200114)2.07820527
78Abnormality of the renal cortex (HP:0011035)2.05096571
79Pulmonary embolism (HP:0002204)2.04966566
80Joint swelling (HP:0001386)2.01075115
81Epistaxis (HP:0000421)1.97395236
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92273170
83Gangrene (HP:0100758)1.91101339
84Gingivitis (HP:0000230)1.90030052
85Hyperlipoproteinemia (HP:0010980)1.89290990
86Acute hepatic failure (HP:0006554)1.89193186
87IgA deficiency (HP:0002720)1.88298878
88Agammaglobulinemia (HP:0004432)1.85774909
89Chronic otitis media (HP:0000389)1.83070394
90Hypokalemic alkalosis (HP:0001949)1.81949115
91Gingival bleeding (HP:0000225)1.81607089
92Nasal polyposis (HP:0100582)1.81262340
93B lymphocytopenia (HP:0010976)1.78157688
94Arterial thrombosis (HP:0004420)1.77329256
95Recurrent sinusitis (HP:0011108)1.76092417
96Segmental peripheral demyelination/remyelination (HP:0003481)1.75108392
97Glomerulopathy (HP:0100820)1.74432431
98Sepsis (HP:0100806)1.73851503
99Somatic mutation (HP:0001428)1.72758455
100Petechiae (HP:0000967)1.70647969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.13409376
2TXK4.23836575
3MAP4K14.16503768
4PINK13.64355372
5CAMKK23.59840345
6CAMKK13.52022981
7IRAK43.29117592
8GRK62.70677873
9TAOK12.47882720
10TAOK22.32275339
11MAP2K32.31753829
12ITK2.30577806
13RIPK42.24805818
14PRPF4B2.03055943
15MAP3K32.01416583
16ZAP702.01369507
17FES1.98478608
18CSK1.97100332
19MAP3K111.93268594
20TYK21.86666900
21JAK31.79456025
22BLK1.77148579
23BTK1.72981740
24HCK1.64215571
25IKBKE1.55883968
26TAOK31.54481798
27TNK21.54436723
28LCK1.49913877
29SYK1.45268139
30NLK1.42563342
31MAP3K101.37125939
32NEK61.24718940
33JAK11.21455863
34TEC1.19707772
35KDR1.18370167
36MAP3K141.11829837
37LYN1.10327469
38JAK20.99910825
39MAP3K10.99504049
40EPHB10.98904703
41FGFR40.90955127
42PRKD20.89372205
43IKBKB0.83657024
44MARK30.83513751
45PRKCQ0.81481772
46NME10.81133362
47SIK30.79838150
48MAP3K130.78211098
49FGFR30.77490219
50ERN10.75565357
51CDK40.71674877
52PIM10.64075457
53CDK190.62776953
54PDK10.59687625
55CAMK40.58424694
56FYN0.58091194
57STK380.57307594
58TBK10.55540744
59STK100.49920425
60TRPM70.49645026
61PIK3CG0.48173394
62KIT0.47971177
63MAPK120.47773625
64SMG10.46882253
65CAMK10.45330103
66MAP3K120.43322190
67SGK30.40808254
68SIK20.40209525
69FGR0.38999094
70MAP3K50.38753557
71CSF1R0.38329132
72IGF1R0.37740960
73HIPK20.37425954
74MAPK110.35546251
75PDPK10.35026226
76CLK10.32685761
77EGFR0.32491837
78YES10.31988619
79STK40.29898797
80PRKCH0.29023343
81CDK60.28434149
82WNK10.27910747
83KSR20.27904878
84MAPK70.27293505
85TYRO30.26731495
86MAP3K20.26592640
87RAF10.26049407
88NTRK30.25679849
89IRAK10.24139015
90MAP3K80.23193651
91GRK70.21554969
92EPHA30.20658520
93MAP3K70.19716632
94PDGFRB0.18603431
95MARK20.18577190
96PRKCD0.17872921
97TESK20.16439164
98PTK60.14368719
99ADRBK20.13243199
100LRRK20.12279826

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.95268122
2T cell receptor signaling pathway_Homo sapiens_hsa046603.41156479
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.05052208
4Autoimmune thyroid disease_Homo sapiens_hsa053202.86775581
5Allograft rejection_Homo sapiens_hsa053302.79686776
6Type I diabetes mellitus_Homo sapiens_hsa049402.79125113
7Graft-versus-host disease_Homo sapiens_hsa053322.74725120
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.67309769
9Osteoclast differentiation_Homo sapiens_hsa043802.50730437
10Measles_Homo sapiens_hsa051622.39521900
11Antigen processing and presentation_Homo sapiens_hsa046122.30677085
12Hematopoietic cell lineage_Homo sapiens_hsa046402.29731400
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18645317
14B cell receptor signaling pathway_Homo sapiens_hsa046622.13047144
15Leishmaniasis_Homo sapiens_hsa051402.03774222
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96347172
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92122136
18Viral myocarditis_Homo sapiens_hsa054161.83292740
19TNF signaling pathway_Homo sapiens_hsa046681.79149634
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74664268
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.70814638
22Herpes simplex infection_Homo sapiens_hsa051681.55670259
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.52794034
24Acute myeloid leukemia_Homo sapiens_hsa052211.52361922
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50015594
26Tuberculosis_Homo sapiens_hsa051521.47053879
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46218388
28Staphylococcus aureus infection_Homo sapiens_hsa051501.44907526
29Chemokine signaling pathway_Homo sapiens_hsa040621.38384824
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36253581
31Malaria_Homo sapiens_hsa051441.34971754
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28171877
33Hepatitis B_Homo sapiens_hsa051611.25308563
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21670095
35Toxoplasmosis_Homo sapiens_hsa051451.19587200
36African trypanosomiasis_Homo sapiens_hsa051431.19515683
37Influenza A_Homo sapiens_hsa051641.16199732
38Ribosome_Homo sapiens_hsa030101.12778999
39Apoptosis_Homo sapiens_hsa042101.10049737
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.08137365
41Viral carcinogenesis_Homo sapiens_hsa052030.98598763
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93521141
43HTLV-I infection_Homo sapiens_hsa051660.93219625
44Pancreatic cancer_Homo sapiens_hsa052120.92287332
45Asthma_Homo sapiens_hsa053100.90363772
46Platelet activation_Homo sapiens_hsa046110.90296233
47VEGF signaling pathway_Homo sapiens_hsa043700.87233925
48Caffeine metabolism_Homo sapiens_hsa002320.85987897
49Non-small cell lung cancer_Homo sapiens_hsa052230.85704230
50Epstein-Barr virus infection_Homo sapiens_hsa051690.78349512
51Rheumatoid arthritis_Homo sapiens_hsa053230.73633360
52Renal cell carcinoma_Homo sapiens_hsa052110.71507041
53Hepatitis C_Homo sapiens_hsa051600.71120681
54Legionellosis_Homo sapiens_hsa051340.71092270
55Shigellosis_Homo sapiens_hsa051310.68973502
56Colorectal cancer_Homo sapiens_hsa052100.67904421
57Prolactin signaling pathway_Homo sapiens_hsa049170.66685885
58MAPK signaling pathway_Homo sapiens_hsa040100.66200845
59FoxO signaling pathway_Homo sapiens_hsa040680.65720304
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64078532
61Endocytosis_Homo sapiens_hsa041440.62728275
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.62476519
63Pertussis_Homo sapiens_hsa051330.61521706
64Proteasome_Homo sapiens_hsa030500.59961528
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55807461
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51147213
67Phagosome_Homo sapiens_hsa041450.49939018
68Choline metabolism in cancer_Homo sapiens_hsa052310.48683298
69Chronic myeloid leukemia_Homo sapiens_hsa052200.47770758
70Long-term potentiation_Homo sapiens_hsa047200.46800023
71Ras signaling pathway_Homo sapiens_hsa040140.46429611
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.44855406
73Dorso-ventral axis formation_Homo sapiens_hsa043200.44298300
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43521597
75mTOR signaling pathway_Homo sapiens_hsa041500.42519110
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41863425
77Inositol phosphate metabolism_Homo sapiens_hsa005620.40853060
78Spliceosome_Homo sapiens_hsa030400.40185618
79Regulation of autophagy_Homo sapiens_hsa041400.38125716
80Insulin resistance_Homo sapiens_hsa049310.37845993
81Rap1 signaling pathway_Homo sapiens_hsa040150.36319389
82RNA degradation_Homo sapiens_hsa030180.36112726
83Notch signaling pathway_Homo sapiens_hsa043300.34541230
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.32419062
85Type II diabetes mellitus_Homo sapiens_hsa049300.30392943
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29708838
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29195249
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27834466
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27768562
90Endometrial cancer_Homo sapiens_hsa052130.27691871
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27525351
92HIF-1 signaling pathway_Homo sapiens_hsa040660.27002948
93Thyroid cancer_Homo sapiens_hsa052160.26502262
94Glycerolipid metabolism_Homo sapiens_hsa005610.25216599
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23916772
96GnRH signaling pathway_Homo sapiens_hsa049120.23747621
97Base excision repair_Homo sapiens_hsa034100.23345619
98Salmonella infection_Homo sapiens_hsa051320.22204302
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.20343596
100Prostate cancer_Homo sapiens_hsa052150.18495272

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