TRAV20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)7.76518299
2positive regulation of gamma-delta T cell activation (GO:0046645)7.29995016
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.16378223
4negative T cell selection (GO:0043383)7.09630482
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.01158181
6negative regulation of cell killing (GO:0031342)7.01158181
7negative thymic T cell selection (GO:0045060)6.88409017
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.63564700
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.06657920
10regulation of regulatory T cell differentiation (GO:0045589)6.03355998
11regulation of gamma-delta T cell differentiation (GO:0045586)5.80786778
12response to interleukin-15 (GO:0070672)5.73568680
13cellular response to interleukin-15 (GO:0071350)5.70679368
14antigen processing and presentation of endogenous antigen (GO:0019883)5.44456459
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.44089373
16regulation of gamma-delta T cell activation (GO:0046643)5.39028938
17regulation of isotype switching to IgG isotypes (GO:0048302)5.35788743
18regulation of T cell tolerance induction (GO:0002664)5.34057244
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.25741155
20thymic T cell selection (GO:0045061)5.25033622
21regulation of B cell receptor signaling pathway (GO:0050855)5.18557609
22negative regulation of T cell mediated immunity (GO:0002710)5.18044188
23T cell selection (GO:0045058)5.04676270
24positive regulation of tolerance induction (GO:0002645)4.83942621
25positive T cell selection (GO:0043368)4.70177959
26T cell migration (GO:0072678)4.60255196
27regulation of tolerance induction (GO:0002643)4.58438843
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.53368846
29activated T cell proliferation (GO:0050798)4.49707527
30leukocyte aggregation (GO:0070486)4.46507651
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.46262676
32positive thymic T cell selection (GO:0045059)4.44637217
33regulation of alpha-beta T cell proliferation (GO:0046640)4.25406969
34positive regulation of granulocyte differentiation (GO:0030854)4.21122524
35T cell receptor signaling pathway (GO:0050852)4.04293231
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.96831272
37positive regulation of T cell differentiation in thymus (GO:0033089)3.94504256
38interferon-gamma production (GO:0032609)3.93670163
39positive regulation of alpha-beta T cell proliferation (GO:0046641)3.86332864
40antigen processing and presentation via MHC class Ib (GO:0002475)3.84509214
41antigen receptor-mediated signaling pathway (GO:0050851)3.81747507
42regulation of T cell mediated cytotoxicity (GO:0001914)3.78591901
43negative regulation of leukocyte mediated immunity (GO:0002704)3.78249284
44regulation of natural killer cell mediated immunity (GO:0002715)3.76941408
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.76941408
46alpha-beta T cell differentiation (GO:0046632)3.74243219
47T cell homeostasis (GO:0043029)3.70832878
48positive regulation of B cell differentiation (GO:0045579)3.64481999
49positive regulation of T cell mediated cytotoxicity (GO:0001916)3.63320284
50regulation of B cell differentiation (GO:0045577)3.61731948
51negative regulation of interleukin-12 production (GO:0032695)3.55135428
52positive regulation of humoral immune response (GO:0002922)3.52231848
53B cell receptor signaling pathway (GO:0050853)3.51214143
54positive regulation of interleukin-4 production (GO:0032753)3.50321227
55regulation of T cell receptor signaling pathway (GO:0050856)3.45917003
56alpha-beta T cell activation (GO:0046631)3.41982553
57type I interferon signaling pathway (GO:0060337)3.38929845
58cellular response to type I interferon (GO:0071357)3.38929845
59regulation of leukocyte mediated cytotoxicity (GO:0001910)3.38208055
60mast cell activation (GO:0045576)3.37461996
61regulation of defense response to virus by virus (GO:0050690)3.36672182
62response to type I interferon (GO:0034340)3.35827642
63positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.33669523
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.33329383
65modulation by symbiont of host defense response (GO:0052031)3.32099731
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.32099731
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.32099731
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.32099731
69modulation by symbiont of host immune response (GO:0052553)3.32099731
70positive regulation by symbiont of host defense response (GO:0052509)3.32099731
71T cell costimulation (GO:0031295)3.31622766
72negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.31307087
73detection of bacterium (GO:0016045)3.29354465
74lymphocyte costimulation (GO:0031294)3.28084599
75detection of other organism (GO:0098543)3.27209659
76NIK/NF-kappaB signaling (GO:0038061)3.26214627
77regulation of isotype switching (GO:0045191)3.25014186
78positive regulation of interleukin-2 production (GO:0032743)3.24149301
79negative regulation of immunoglobulin mediated immune response (GO:0002890)3.19800949
80negative regulation of B cell mediated immunity (GO:0002713)3.19800949
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.19231877
82T cell differentiation (GO:0030217)3.18468956
83positive regulation of natural killer cell mediated immunity (GO:0002717)3.18061611
84negative regulation of adaptive immune response (GO:0002820)3.17174689
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13068187
86CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.11930463
87cellular extravasation (GO:0045123)3.11656612
88lymphocyte migration (GO:0072676)3.11164716
89regulation of alpha-beta T cell activation (GO:0046634)3.10130859
90regulation of cell killing (GO:0031341)3.08014984
91positive regulation of isotype switching (GO:0045830)3.06952933
92myeloid dendritic cell differentiation (GO:0043011)3.06587147
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06371833
94positive regulation of cell killing (GO:0031343)3.05391267
95positive regulation of T cell mediated immunity (GO:0002711)3.04619751
96neutrophil activation involved in immune response (GO:0002283)3.01884311
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.01057320
98regulation of T cell mediated immunity (GO:0002709)3.00686411
99regulation of interleukin-4 production (GO:0032673)2.99952501
100dendritic cell chemotaxis (GO:0002407)2.99717310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.48277637
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.61186698
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.02819971
4RUNX_20019798_ChIP-Seq_JUKART_Human3.98157532
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.60625688
6MYB_26560356_Chip-Seq_TH2_Human3.52873081
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37045097
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32166808
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.28147660
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21713475
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.13830425
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.03158008
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94012832
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92043673
15MAF_26560356_Chip-Seq_TH1_Human2.91596126
16MYB_26560356_Chip-Seq_TH1_Human2.78669135
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76717041
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57156351
19UTX_26944678_Chip-Seq_JUKART_Human2.56437034
20SPI1_23547873_ChIP-Seq_NB4_Human2.37727836
21MYC_22102868_ChIP-Seq_BL_Human2.33158900
22GATA3_27048872_Chip-Seq_THYMUS_Human2.32427303
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.31630955
24MAF_26560356_Chip-Seq_TH2_Human2.29312044
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28664708
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25499745
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21667344
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19028069
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01440539
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.95348581
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90574968
32VDR_21846776_ChIP-Seq_THP-1_Human1.87190950
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.86828319
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.81071759
35GATA3_26560356_Chip-Seq_TH2_Human1.81024060
36SCL_19346495_ChIP-Seq_HPC-7_Human1.74369316
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73877038
38SPI1_23127762_ChIP-Seq_K562_Human1.73014351
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71827617
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70756541
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68549210
42VDR_24763502_ChIP-Seq_THP-1_Human1.66370392
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65712532
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64432471
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63788674
46TCF7_22412390_ChIP-Seq_EML_Mouse1.62677736
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53590532
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.47527166
49CIITA_25753668_ChIP-Seq_RAJI_Human1.44969705
50KDM2B_26808549_Chip-Seq_DND41_Human1.40989007
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37838605
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37321941
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34933858
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33755125
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32493808
56PU_27001747_Chip-Seq_BMDM_Mouse1.30122029
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26373257
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25152215
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24870392
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23270900
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21559213
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21328505
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20813862
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20617821
65VDR_23849224_ChIP-Seq_CD4+_Human1.20553980
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.15699167
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12582764
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11470691
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10036134
70FOXP3_21729870_ChIP-Seq_TREG_Human1.09480947
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02039608
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01698382
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01288214
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01169664
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01162723
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.00466890
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00057732
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98869101
79VDR_24787735_ChIP-Seq_THP-1_Human0.95871548
80HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94283530
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91952359
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91081325
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.89135006
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86895557
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86615901
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85029534
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83829974
88GATA1_22025678_ChIP-Seq_K562_Human0.80591342
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.80005467
90GATA3_26560356_Chip-Seq_TH1_Human0.79995363
91GATA1_19941826_ChIP-Seq_K562_Human0.77360952
92NCOR1_26117541_ChIP-Seq_K562_Human0.75715684
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74085100
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71769781
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70686032
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.68916337
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68434137
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.67445303
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.66489947
100SMRT_27268052_Chip-Seq_Bcells_Human0.65300418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.93807704
2MP0005671_abnormal_response_to4.44953813
3MP0003436_decreased_susceptibility_to3.64912501
4MP0001835_abnormal_antigen_presentation3.48821318
5MP0001800_abnormal_humoral_immune3.35321372
6MP0003724_increased_susceptibility_to3.21247195
7MP0005000_abnormal_immune_tolerance3.19971979
8MP0001873_stomach_inflammation3.13583097
9MP0009333_abnormal_splenocyte_physiolog3.03377283
10MP0000685_abnormal_immune_system2.90358979
11MP0005387_immune_system_phenotype2.87518731
12MP0001790_abnormal_immune_system2.87518731
13MP0002723_abnormal_immune_serum2.76722791
14MP0002420_abnormal_adaptive_immunity2.74195763
15MP0001819_abnormal_immune_cell2.70182102
16MP0005025_abnormal_response_to2.62686470
17MP0009785_altered_susceptibility_to2.62504124
18MP0002452_abnormal_antigen_presenting2.58637356
19MP0003866_abnormal_defecation2.53774445
20MP0000703_abnormal_thymus_morphology2.52741412
21MP0002398_abnormal_bone_marrow2.45399237
22MP0003300_gastrointestinal_ulcer2.43001464
23MP0002405_respiratory_system_inflammati2.40831460
24MP0002148_abnormal_hypersensitivity_rea2.39476049
25MP0002419_abnormal_innate_immunity2.35887088
26MP0003303_peritoneal_inflammation2.34157838
27MP0000716_abnormal_immune_system2.23473116
28MP0010155_abnormal_intestine_physiology2.16051585
29MP0004381_abnormal_hair_follicle2.11904240
30MP0006082_CNS_inflammation2.09801633
31MP0004947_skin_inflammation2.03611761
32MP0000465_gastrointestinal_hemorrhage2.01957143
33MP0002277_abnormal_respiratory_mucosa2.01450759
34MP0002722_abnormal_immune_system2.01012020
35MP0000689_abnormal_spleen_morphology1.99707728
36MP0005310_abnormal_salivary_gland1.94897381
37MP0005075_abnormal_melanosome_morpholog1.85094388
38MP0002166_altered_tumor_susceptibility1.75327187
39MP0002429_abnormal_blood_cell1.75064528
40MP0005464_abnormal_platelet_physiology1.72170587
41MP0001845_abnormal_inflammatory_respons1.72162052
42MP0001348_abnormal_lacrimal_gland1.70629319
43MP0008260_abnormal_autophagy1.57947457
44MP0001851_eye_inflammation1.56123847
45MP0001533_abnormal_skeleton_physiology1.52679101
46MP0002396_abnormal_hematopoietic_system1.46856425
47MP0002163_abnormal_gland_morphology1.45607721
48MP0001853_heart_inflammation1.33437281
49MP0008469_abnormal_protein_level1.27139721
50MP0002006_tumorigenesis1.19066769
51MP0002933_joint_inflammation1.18265767
52MP0000490_abnormal_crypts_of1.17103947
53MP0003172_abnormal_lysosome_physiology1.09962581
54MP0002132_abnormal_respiratory_system1.09663664
55MP0002009_preneoplasia1.06234548
56MP0009764_decreased_sensitivity_to1.01328009
57MP0002138_abnormal_hepatobiliary_system0.99382841
58MP0001663_abnormal_digestive_system0.99135752
59MP0003045_fibrosis0.98151956
60MP0000858_altered_metastatic_potential0.97099186
61MP0003191_abnormal_cellular_cholesterol0.86881435
62MP0009763_increased_sensitivity_to0.85495284
63MP0002998_abnormal_bone_remodeling0.84572462
64MP0009278_abnormal_bone_marrow0.83264311
65MP0003828_pulmonary_edema0.79566881
66MP0005451_abnormal_body_composition0.78233696
67MP0004883_abnormal_blood_vessel0.77161480
68MP0004510_myositis0.76911579
69MP0002019_abnormal_tumor_incidence0.75411456
70MP0002693_abnormal_pancreas_physiology0.74639704
71MP0000015_abnormal_ear_pigmentation0.74281329
72MP0005379_endocrine/exocrine_gland_phen0.72285777
73MP0003448_altered_tumor_morphology0.68907384
74MP0000604_amyloidosis0.65754611
75MP0004808_abnormal_hematopoietic_stem0.64193436
76MP0004130_abnormal_muscle_cell0.64141947
77MP0005166_decreased_susceptibility_to0.62392877
78MP0003091_abnormal_cell_migration0.60303409
79MP0009765_abnormal_xenobiotic_induced0.57640982
80MP0001919_abnormal_reproductive_system0.57184993
81MP0001346_abnormal_lacrimal_gland0.55993377
82MP0005381_digestive/alimentary_phenotyp0.54368742
83MP0000569_abnormal_digit_pigmentation0.54012468
84MP0008961_abnormal_basal_metabolism0.52893482
85MP0005390_skeleton_phenotype0.51598394
86MP0003795_abnormal_bone_structure0.50637634
87MP0000249_abnormal_blood_vessel0.49415359
88MP0003221_abnormal_cardiomyocyte_apopto0.48569317
89MP0005164_abnormal_response_to0.47051614
90MP0008057_abnormal_DNA_replication0.45537487
91MP0002254_reproductive_system_inflammat0.45236115
92MP0001545_abnormal_hematopoietic_system0.44821972
93MP0005397_hematopoietic_system_phenotyp0.44821972
94MP0008874_decreased_physiological_sensi0.41671244
95MP0000371_diluted_coat_color0.41618919
96MP0008569_lethality_at_weaning0.40996137
97MP0000609_abnormal_liver_physiology0.40756622
98MP0003183_abnormal_peptide_metabolism0.39778937
99MP0003787_abnormal_imprinting0.37275954
100MP0001765_abnormal_ion_homeostasis0.36709205

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.97070109
2Elevated erythrocyte sedimentation rate (HP:0003565)6.41503893
3T lymphocytopenia (HP:0005403)6.25984267
4Abnormality of T cell number (HP:0011839)5.94560535
5Eczematoid dermatitis (HP:0000976)5.86542129
6Autoimmune hemolytic anemia (HP:0001890)5.56131504
7Myositis (HP:0100614)5.09647374
8Abnormality of T cells (HP:0002843)4.92407600
9Recurrent bacterial skin infections (HP:0005406)4.47026185
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.40885245
11Recurrent abscess formation (HP:0002722)4.39693571
12IgG deficiency (HP:0004315)4.38789227
13Severe combined immunodeficiency (HP:0004430)4.38687387
14Retrobulbar optic neuritis (HP:0100654)4.33106648
15Optic neuritis (HP:0100653)4.33106648
16Recurrent fungal infections (HP:0002841)4.30591027
17IgM deficiency (HP:0002850)4.29810061
18Orchitis (HP:0100796)4.25051606
19Increased IgM level (HP:0003496)3.97736077
20Gastrointestinal infarctions (HP:0005244)3.93576701
21Mediastinal lymphadenopathy (HP:0100721)3.86312587
22Abnormality of T cell physiology (HP:0011840)3.83660429
23Recurrent bronchitis (HP:0002837)3.81267816
24Abnormality of macrophages (HP:0004311)3.81071872
25Vasculitis (HP:0002633)3.70427230
26Meningitis (HP:0001287)3.62382485
27Encephalitis (HP:0002383)3.53562431
28Abnormality of eosinophils (HP:0001879)3.52209215
29Obstructive lung disease (HP:0006536)3.50195084
30Chronic obstructive pulmonary disease (HP:0006510)3.50195084
31Combined immunodeficiency (HP:0005387)3.49165597
32Chronic mucocutaneous candidiasis (HP:0002728)3.48776056
33Recurrent cutaneous fungal infections (HP:0011370)3.48776056
34Leukocytosis (HP:0001974)3.45313578
35Pustule (HP:0200039)3.44407086
36Pulmonary infiltrates (HP:0002113)3.40343091
37Lymphopenia (HP:0001888)3.39385226
38Granulocytopenia (HP:0001913)3.39131027
39Recurrent viral infections (HP:0004429)3.26932939
40Keratoconjunctivitis sicca (HP:0001097)3.25701361
41Abnormality of cells of the lymphoid lineage (HP:0012140)3.24833157
42Recurrent skin infections (HP:0001581)3.24738096
43Eosinophilia (HP:0001880)3.23762936
44Spontaneous hematomas (HP:0007420)3.20023973
45Panhypogammaglobulinemia (HP:0003139)3.19462057
46Increased IgE level (HP:0003212)3.17944719
47Chronic diarrhea (HP:0002028)3.13511815
48Abnormality of B cell number (HP:0010975)3.10384841
49B lymphocytopenia (HP:0010976)3.09811670
50Keratoconjunctivitis (HP:0001096)3.04680355
51Recurrent gram-negative bacterial infections (HP:0005420)3.01041086
52Chest pain (HP:0100749)3.00440793
53Hypochromic microcytic anemia (HP:0004840)2.98232361
54Hypochromic anemia (HP:0001931)2.93098197
55Joint swelling (HP:0001386)2.84645578
56Hemoptysis (HP:0002105)2.82599405
57Gingivitis (HP:0000230)2.75745627
58Thyroiditis (HP:0100646)2.74908716
59Inflammation of the large intestine (HP:0002037)2.70286018
60Hypergammaglobulinemia (HP:0010702)2.68542827
61Gastrointestinal inflammation (HP:0004386)2.63928977
62Urticaria (HP:0001025)2.58413484
63Prolonged bleeding time (HP:0003010)2.57071441
64Pulmonary embolism (HP:0002204)2.55622784
65Papilledema (HP:0001085)2.47174737
66Lymphoma (HP:0002665)2.45433771
67Epistaxis (HP:0000421)2.45125470
68IgA deficiency (HP:0002720)2.44933564
69Gangrene (HP:0100758)2.40927897
70Autoimmune thrombocytopenia (HP:0001973)2.39538506
71Agammaglobulinemia (HP:0004432)2.39308266
72Acute hepatic failure (HP:0006554)2.31813369
73Slow saccadic eye movements (HP:0000514)2.30415506
74Hypoplasia of the thymus (HP:0000778)2.30408378
75Anorexia (HP:0002039)2.29431752
76Microcytic anemia (HP:0001935)2.28043650
77Papilloma (HP:0012740)2.26506578
78Verrucae (HP:0200043)2.26506578
79Recurrent sinusitis (HP:0011108)2.26415917
80Gingival bleeding (HP:0000225)2.24640638
81Gastrointestinal stroma tumor (HP:0100723)2.19373943
82Arterial thrombosis (HP:0004420)2.18408324
83Abnormality of the pleura (HP:0002103)2.16125342
84Bronchitis (HP:0012387)2.14914897
85Sepsis (HP:0100806)2.12110007
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11741816
87Glomerulopathy (HP:0100820)2.07060092
88Abnormality of the prostate (HP:0008775)2.06996559
89Cellulitis (HP:0100658)2.02477158
90Colitis (HP:0002583)1.99609263
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.93882345
92Petechiae (HP:0000967)1.93833654
93Episodic fever (HP:0001954)1.93823500
94Chronic otitis media (HP:0000389)1.92676071
95Basal cell carcinoma (HP:0002671)1.89378469
96Fatigue (HP:0012378)1.88049574
97Arthralgia (HP:0002829)1.86996450
98Stomach cancer (HP:0012126)1.86846021
99Skin rash (HP:0000988)1.84173162
100Abnormality of the fingertips (HP:0001211)1.82683662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.64131332
2MAP4K14.80928929
3RIPK42.87949200
4FES2.83821689
5ITK2.78758079
6CSK2.56042852
7TYK22.48194471
8ZAP702.35556205
9BTK2.25020506
10GRK62.21547120
11NLK2.15652750
12IKBKE2.14079351
13MAP3K132.13407308
14JAK32.07510247
15PASK2.06784410
16PRPF4B2.00958931
17LCK1.95435450
18SIK31.84608887
19IRAK41.84533411
20TEC1.83925399
21JAK11.80672828
22SYK1.79881492
23FGFR41.74403771
24HCK1.73197015
25EPHB11.69545961
26TAOK31.66305909
27CAMKK21.58439874
28BLK1.53159644
29MAP3K141.51711615
30MAP2K31.47317999
31TNK21.44684842
32CAMKK11.35784050
33TBK11.29611226
34LYN1.28124034
35STK101.25835578
36MARK31.22704575
37FGFR31.22275023
38MST41.13612285
39JAK21.11264274
40ERN11.01971610
41PRKCQ1.00704159
42MAPK111.00182303
43IKBKB0.98288018
44MAP3K10.96216550
45TYRO30.92578835
46EPHA30.92526095
47MAP3K30.92062089
48TAOK10.91933396
49MAP3K110.91117598
50LRRK20.89304687
51CSF1R0.88498157
52KSR20.84684666
53FGR0.84044687
54SIK20.83841902
55CLK10.75508630
56PIM10.73014985
57PDK10.72165992
58IRAK10.72147827
59TAOK20.70439971
60FYN0.69520493
61TESK20.67732333
62YES10.61530467
63HIPK20.61107064
64CDK40.59470598
65MAPK120.58254928
66MARK20.57695986
67MAP3K100.55727125
68GRK70.52511358
69PIK3CG0.50192904
70RAF10.49446199
71PTK60.46955062
72MAP3K70.46616991
73KIT0.46575295
74MAP3K120.43656798
75PDGFRB0.43568634
76CDK190.43517242
77TGFBR20.42746763
78NEK60.42636788
79ARAF0.38115030
80STK380.37758140
81BMPR20.37664371
82MOS0.35783462
83PRKCH0.35507436
84MAPK70.33346804
85MAPKAPK20.30738067
86MAP2K60.30030704
87CDK120.29040702
88RET0.29034397
89SGK30.27416749
90MAP3K50.27344717
91EGFR0.27193061
92DYRK1B0.26643271
93IRAK20.26322825
94SGK20.26075189
95SCYL20.25438623
96SIK10.24763966
97NTRK20.24365577
98BRD40.24050270
99SMG10.23091869
100CHUK0.22294423

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.94052689
2T cell receptor signaling pathway_Homo sapiens_hsa046603.71574315
3Autoimmune thyroid disease_Homo sapiens_hsa053202.98983554
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.90133228
5Allograft rejection_Homo sapiens_hsa053302.88614659
6Measles_Homo sapiens_hsa051622.65377040
7Graft-versus-host disease_Homo sapiens_hsa053322.64871880
8Osteoclast differentiation_Homo sapiens_hsa043802.48085839
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44223311
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.20421649
11Hematopoietic cell lineage_Homo sapiens_hsa046402.06693829
12B cell receptor signaling pathway_Homo sapiens_hsa046622.06334881
13Type I diabetes mellitus_Homo sapiens_hsa049401.98451040
14Leishmaniasis_Homo sapiens_hsa051401.95582489
15Acute myeloid leukemia_Homo sapiens_hsa052211.89535017
16Antigen processing and presentation_Homo sapiens_hsa046121.85144722
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83578816
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.79813742
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.76149426
20Viral myocarditis_Homo sapiens_hsa054161.74661679
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69686571
22Chemokine signaling pathway_Homo sapiens_hsa040621.69617697
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65995752
24Herpes simplex infection_Homo sapiens_hsa051681.62440287
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56773460
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50488971
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42748836
28Hepatitis B_Homo sapiens_hsa051611.40615881
29Tuberculosis_Homo sapiens_hsa051521.36807128
30TNF signaling pathway_Homo sapiens_hsa046681.34042436
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32926899
32Staphylococcus aureus infection_Homo sapiens_hsa051501.32653509
33Non-small cell lung cancer_Homo sapiens_hsa052231.31789698
34Malaria_Homo sapiens_hsa051441.31067504
35Toxoplasmosis_Homo sapiens_hsa051451.26759202
36Influenza A_Homo sapiens_hsa051641.24817794
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20491283
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.18797934
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15597518
40Pancreatic cancer_Homo sapiens_hsa052121.09373922
41Legionellosis_Homo sapiens_hsa051341.03308079
42Viral carcinogenesis_Homo sapiens_hsa052031.03065876
43Apoptosis_Homo sapiens_hsa042101.02277140
44Hepatitis C_Homo sapiens_hsa051601.00876511
45Shigellosis_Homo sapiens_hsa051310.99385959
46Epstein-Barr virus infection_Homo sapiens_hsa051690.98839706
47Asthma_Homo sapiens_hsa053100.97816692
48Platelet activation_Homo sapiens_hsa046110.95872754
49VEGF signaling pathway_Homo sapiens_hsa043700.94879156
50HTLV-I infection_Homo sapiens_hsa051660.94860092
51Colorectal cancer_Homo sapiens_hsa052100.89954402
52Prolactin signaling pathway_Homo sapiens_hsa049170.89122289
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86462781
54Chronic myeloid leukemia_Homo sapiens_hsa052200.85698196
55African trypanosomiasis_Homo sapiens_hsa051430.84947639
56FoxO signaling pathway_Homo sapiens_hsa040680.84340141
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80617214
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76087449
59Regulation of autophagy_Homo sapiens_hsa041400.75149659
60Endocytosis_Homo sapiens_hsa041440.73229199
61Renal cell carcinoma_Homo sapiens_hsa052110.72782323
62Endometrial cancer_Homo sapiens_hsa052130.70878944
63Rheumatoid arthritis_Homo sapiens_hsa053230.70014513
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.69767325
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.69606589
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67681447
67Pertussis_Homo sapiens_hsa051330.59903451
68Phagosome_Homo sapiens_hsa041450.54608306
69Inositol phosphate metabolism_Homo sapiens_hsa005620.53753611
70MAPK signaling pathway_Homo sapiens_hsa040100.51302774
71Choline metabolism in cancer_Homo sapiens_hsa052310.50467685
72Thyroid cancer_Homo sapiens_hsa052160.49754320
73Salmonella infection_Homo sapiens_hsa051320.48511373
74mTOR signaling pathway_Homo sapiens_hsa041500.47007960
75Prostate cancer_Homo sapiens_hsa052150.45645537
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44663058
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44278446
78Insulin resistance_Homo sapiens_hsa049310.43086316
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42665324
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.40081784
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.39383959
82HIF-1 signaling pathway_Homo sapiens_hsa040660.39292174
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39195096
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35419531
85Long-term potentiation_Homo sapiens_hsa047200.34399848
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34399446
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33942402
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33932963
89Dorso-ventral axis formation_Homo sapiens_hsa043200.33591330
90Ras signaling pathway_Homo sapiens_hsa040140.29687161
91ErbB signaling pathway_Homo sapiens_hsa040120.29512509
92Notch signaling pathway_Homo sapiens_hsa043300.28265566
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.23996046
94Other glycan degradation_Homo sapiens_hsa005110.23878023
95Rap1 signaling pathway_Homo sapiens_hsa040150.23731839
96Glioma_Homo sapiens_hsa052140.21181974
97Type II diabetes mellitus_Homo sapiens_hsa049300.19804910
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18893804
99GnRH signaling pathway_Homo sapiens_hsa049120.18821023
100Circadian rhythm_Homo sapiens_hsa047100.18036289

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