TRAV14DV4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.53617158
2negative T cell selection (GO:0043383)7.01980453
3regulation of regulatory T cell differentiation (GO:0045589)6.86450986
4negative regulation of cell killing (GO:0031342)6.69071330
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.69071330
6negative thymic T cell selection (GO:0045060)6.32688345
7positive T cell selection (GO:0043368)6.29035523
8positive thymic T cell selection (GO:0045059)6.05292294
9positive regulation of gamma-delta T cell activation (GO:0046645)6.01324332
10leukocyte aggregation (GO:0070486)5.89681430
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.85737055
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.75462306
13regulation of isotype switching to IgG isotypes (GO:0048302)5.52519059
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.35365004
15T cell migration (GO:0072678)5.33783792
16thymic T cell selection (GO:0045061)5.32662782
17antigen processing and presentation of endogenous antigen (GO:0019883)5.31913458
18positive regulation of interleukin-17 production (GO:0032740)5.27211397
19regulation of T cell tolerance induction (GO:0002664)5.24748775
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.19355095
21T cell selection (GO:0045058)5.14617102
22cellular response to interleukin-15 (GO:0071350)4.94234006
23positive regulation of tolerance induction (GO:0002645)4.84903574
24regulation of gamma-delta T cell differentiation (GO:0045586)4.84646160
25activated T cell proliferation (GO:0050798)4.78345932
26response to interleukin-15 (GO:0070672)4.73714891
27regulation of T cell mediated cytotoxicity (GO:0001914)4.72066907
28positive regulation of T cell mediated cytotoxicity (GO:0001916)4.69512394
29regulation of gamma-delta T cell activation (GO:0046643)4.65676764
30positive regulation of granulocyte differentiation (GO:0030854)4.51499153
31regulation of tolerance induction (GO:0002643)4.45221343
32regulation of B cell receptor signaling pathway (GO:0050855)4.42075170
33signal complex assembly (GO:0007172)4.34460125
34tolerance induction (GO:0002507)4.28584927
35negative regulation of T cell mediated immunity (GO:0002710)4.20146452
36regulation of alpha-beta T cell proliferation (GO:0046640)4.19127795
37T cell receptor signaling pathway (GO:0050852)4.18498862
38negative regulation of T cell apoptotic process (GO:0070233)4.18218792
39regulation of B cell differentiation (GO:0045577)4.17945315
40negative regulation of stress fiber assembly (GO:0051497)4.16432473
41positive regulation of B cell differentiation (GO:0045579)4.15627415
42regulation of interleukin-2 biosynthetic process (GO:0045076)4.12039884
43negative regulation of lymphocyte mediated immunity (GO:0002707)4.11757445
44interferon-gamma production (GO:0032609)3.96428906
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.90107634
46positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.86251560
47antigen processing and presentation via MHC class Ib (GO:0002475)3.78116315
48antigen receptor-mediated signaling pathway (GO:0050851)3.75987782
49positive regulation of interleukin-4 production (GO:0032753)3.75668282
50regulation of natural killer cell mediated immunity (GO:0002715)3.71100988
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.71100988
52positive regulation of alpha-beta T cell proliferation (GO:0046641)3.70499434
53positive regulation of lamellipodium assembly (GO:0010592)3.60843023
54negative regulation of lymphocyte apoptotic process (GO:0070229)3.57132392
55positive regulation of isotype switching (GO:0045830)3.52477441
56negative regulation of leukocyte mediated immunity (GO:0002704)3.51803479
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.51159023
58cellular response to type I interferon (GO:0071357)3.50356853
59type I interferon signaling pathway (GO:0060337)3.50356853
60regulation of cell killing (GO:0031341)3.49858286
61positive regulation of cell killing (GO:0031343)3.48159526
62response to type I interferon (GO:0034340)3.46410070
63regulation of interleukin-17 production (GO:0032660)3.42019948
64positive regulation of DNA recombination (GO:0045911)3.39289447
65respiratory burst (GO:0045730)3.37500008
66natural killer cell differentiation (GO:0001779)3.33481220
67alpha-beta T cell differentiation (GO:0046632)3.32405055
68positive regulation of T cell differentiation in thymus (GO:0033089)3.27961309
69T cell differentiation (GO:0030217)3.27863340
70positive regulation of T cell mediated immunity (GO:0002711)3.25411397
71lymphocyte migration (GO:0072676)3.24153345
72positive regulation of calcium-mediated signaling (GO:0050850)3.23778168
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23669684
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23418893
75regulation of T cell mediated immunity (GO:0002709)3.23170609
76Peyers patch development (GO:0048541)3.23017417
77mucosal-associated lymphoid tissue development (GO:0048537)3.23017417
78regulation of defense response to virus by virus (GO:0050690)3.22901982
79regulation of interleukin-4 production (GO:0032673)3.21635276
80positive regulation of macrophage differentiation (GO:0045651)3.19283413
81negative regulation of actin filament bundle assembly (GO:0032232)3.17468313
82T cell homeostasis (GO:0043029)3.16734494
83negative regulation of leukocyte apoptotic process (GO:2000107)3.16456424
84immunoglobulin mediated immune response (GO:0016064)3.12455666
85neutrophil activation involved in immune response (GO:0002283)3.09728858
86T cell costimulation (GO:0031295)3.06791185
87regulation of granulocyte differentiation (GO:0030852)3.06446860
88alpha-beta T cell activation (GO:0046631)3.05830236
89regulation of T cell apoptotic process (GO:0070232)3.05663096
90regulation of alpha-beta T cell activation (GO:0046634)3.03841885
91lymphocyte costimulation (GO:0031294)3.02898360
92positive regulation of natural killer cell mediated immunity (GO:0002717)3.02653370
93negative regulation of interleukin-12 production (GO:0032695)3.02542113
94positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.02223073
95positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.01389501
96regulation of isotype switching (GO:0045191)2.99557410
97positive regulation of interleukin-2 production (GO:0032743)2.99254595
98positive regulation of lymphocyte mediated immunity (GO:0002708)2.97320665
99modulation by symbiont of host immune response (GO:0052553)2.96988705
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96988705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.62206773
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.88689364
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.94968236
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.25832347
5RUNX_20019798_ChIP-Seq_JUKART_Human4.02877084
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52905781
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50206406
8MYB_26560356_Chip-Seq_TH2_Human3.48550758
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.31777676
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.31236533
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.23218292
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.03520176
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.91331969
14UTX_26944678_Chip-Seq_JUKART_Human2.88473442
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85154422
16MAF_26560356_Chip-Seq_TH1_Human2.80643494
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.78503318
18GATA3_27048872_Chip-Seq_THYMUS_Human2.69092184
19MYB_26560356_Chip-Seq_TH1_Human2.67470998
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61338363
21MAF_26560356_Chip-Seq_TH2_Human2.44636591
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41874587
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23300976
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.17898801
25SPI1_23547873_ChIP-Seq_NB4_Human2.14979652
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10536410
27GATA3_26560356_Chip-Seq_TH2_Human2.05475840
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.97829553
29MYC_22102868_ChIP-Seq_BL_Human1.87301238
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84280651
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83445216
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83069883
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81800647
34SCL_19346495_ChIP-Seq_HPC-7_Human1.79368713
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71865135
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64672780
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62488238
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61046411
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.56830957
40SPI1_23127762_ChIP-Seq_K562_Human1.54695494
41VDR_21846776_ChIP-Seq_THP-1_Human1.50433370
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.42770585
43VDR_24763502_ChIP-Seq_THP-1_Human1.42350248
44CIITA_25753668_ChIP-Seq_RAJI_Human1.39404499
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39309749
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37174731
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34178551
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31677711
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30579095
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30526732
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28832181
52TCF7_22412390_ChIP-Seq_EML_Mouse1.28825787
53BCL6_27268052_Chip-Seq_Bcells_Human1.27997364
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24999860
55GATA1_19941826_ChIP-Seq_K562_Human1.19005752
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18308291
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16069317
58VDR_23849224_ChIP-Seq_CD4+_Human1.15276233
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14409572
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14336812
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13730608
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11490211
63RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11297173
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10295643
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.08960290
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07008810
67KDM2B_26808549_Chip-Seq_DND41_Human1.05785211
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04668557
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02582789
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01512473
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01505990
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99070748
73STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98758841
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98057492
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95574647
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95491684
77P300_27268052_Chip-Seq_Bcells_Human0.91527535
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91396892
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91026569
80FOXP3_21729870_ChIP-Seq_TREG_Human0.89733847
81VDR_24787735_ChIP-Seq_THP-1_Human0.89280834
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88243550
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85546725
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83524090
85PU_27001747_Chip-Seq_BMDM_Mouse0.83177129
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82904663
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82724140
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82507946
89BCOR_27268052_Chip-Seq_Bcells_Human0.81990190
90GATA3_26560356_Chip-Seq_TH1_Human0.81218731
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.81109522
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80980898
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79492175
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.79168055
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77262944
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.75301488
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74673268
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74131007
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73460569
100SMRT_27268052_Chip-Seq_Bcells_Human0.73076829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.65625832
2MP0003763_abnormal_thymus_physiology4.22915367
3MP0001835_abnormal_antigen_presentation4.08715315
4MP0003436_decreased_susceptibility_to3.75079838
5MP0009333_abnormal_splenocyte_physiolog3.56077168
6MP0003724_increased_susceptibility_to3.52556823
7MP0005000_abnormal_immune_tolerance3.21797603
8MP0001800_abnormal_humoral_immune3.08222260
9MP0003300_gastrointestinal_ulcer2.84559404
10MP0000685_abnormal_immune_system2.81757993
11MP0002420_abnormal_adaptive_immunity2.75838372
12MP0001790_abnormal_immune_system2.73751164
13MP0005387_immune_system_phenotype2.73751164
14MP0009785_altered_susceptibility_to2.70572196
15MP0005025_abnormal_response_to2.69538979
16MP0001819_abnormal_immune_cell2.68947964
17MP0002723_abnormal_immune_serum2.66007672
18MP0003866_abnormal_defecation2.41377706
19MP0002452_abnormal_antigen_presenting2.39895101
20MP0002148_abnormal_hypersensitivity_rea2.39649153
21MP0002405_respiratory_system_inflammati2.36652833
22MP0002398_abnormal_bone_marrow2.35794817
23MP0002419_abnormal_innate_immunity2.32450089
24MP0000703_abnormal_thymus_morphology2.21133962
25MP0000716_abnormal_immune_system2.20014101
26MP0001853_heart_inflammation2.18908306
27MP0000465_gastrointestinal_hemorrhage2.11809883
28MP0010155_abnormal_intestine_physiology2.11383126
29MP0001873_stomach_inflammation2.08270632
30MP0005464_abnormal_platelet_physiology1.96461518
31MP0006082_CNS_inflammation1.95193562
32MP0002933_joint_inflammation1.91440300
33MP0001348_abnormal_lacrimal_gland1.90714600
34MP0002722_abnormal_immune_system1.89105018
35MP0000689_abnormal_spleen_morphology1.88645932
36MP0002166_altered_tumor_susceptibility1.85720642
37MP0004947_skin_inflammation1.78499225
38MP0002277_abnormal_respiratory_mucosa1.77829967
39MP0002429_abnormal_blood_cell1.71520483
40MP0003787_abnormal_imprinting1.67815174
41MP0004381_abnormal_hair_follicle1.61927882
42MP0005310_abnormal_salivary_gland1.56734253
43MP0001533_abnormal_skeleton_physiology1.56284211
44MP0001845_abnormal_inflammatory_respons1.55344224
45MP0001661_extended_life_span1.47629549
46MP0002138_abnormal_hepatobiliary_system1.43811785
47MP0000490_abnormal_crypts_of1.40036416
48MP0005075_abnormal_melanosome_morpholog1.38488530
49MP0003303_peritoneal_inflammation1.32072070
50MP0002009_preneoplasia1.28459160
51MP0004185_abnormal_adipocyte_glucose1.27765815
52MP0008469_abnormal_protein_level1.27703891
53MP0002006_tumorigenesis1.26721876
54MP0000604_amyloidosis1.23639014
55MP0009764_decreased_sensitivity_to1.10127001
56MP0005379_endocrine/exocrine_gland_phen1.02544490
57MP0004130_abnormal_muscle_cell1.01428889
58MP0005083_abnormal_biliary_tract0.97252127
59MP0002132_abnormal_respiratory_system0.90574279
60MP0009763_increased_sensitivity_to0.88457583
61MP0002693_abnormal_pancreas_physiology0.86469433
62MP0003448_altered_tumor_morphology0.85650714
63MP0001851_eye_inflammation0.84286985
64MP0008874_decreased_physiological_sensi0.83252446
65MP0001764_abnormal_homeostasis0.81765191
66MP0002998_abnormal_bone_remodeling0.81456835
67MP0000858_altered_metastatic_potential0.81113698
68MP0004883_abnormal_blood_vessel0.81111627
69MP0001663_abnormal_digestive_system0.79263910
70MP0003828_pulmonary_edema0.78174481
71MP0003880_abnormal_central_pattern0.76880698
72MP0002396_abnormal_hematopoietic_system0.75000025
73MP0001765_abnormal_ion_homeostasis0.71760452
74MP0002127_abnormal_cardiovascular_syste0.69177431
75MP0002163_abnormal_gland_morphology0.68508419
76MP0003690_abnormal_glial_cell0.68501783
77MP0008004_abnormal_stomach_pH0.66274213
78MP0002019_abnormal_tumor_incidence0.65188815
79MP0000249_abnormal_blood_vessel0.63406739
80MP0009278_abnormal_bone_marrow0.63078587
81MP0005390_skeleton_phenotype0.61928516
82MP0009765_abnormal_xenobiotic_induced0.60189665
83MP0003123_paternal_imprinting0.59582351
84MP0004264_abnormal_extraembryonic_tissu0.58788907
85MP0008260_abnormal_autophagy0.56601717
86MP0005164_abnormal_response_to0.53951001
87MP0005377_hearing/vestibular/ear_phenot0.53543939
88MP0003878_abnormal_ear_physiology0.53543939
89MP0004134_abnormal_chest_morphology0.52392729
90MP0002876_abnormal_thyroid_physiology0.51961143
91MP0003172_abnormal_lysosome_physiology0.51925867
92MP0003252_abnormal_bile_duct0.51168984
93MP0003075_altered_response_to0.49726787
94MP0002928_abnormal_bile_duct0.47781484
95MP0008961_abnormal_basal_metabolism0.43636171
96MP0003191_abnormal_cellular_cholesterol0.43620615
97MP0005376_homeostasis/metabolism_phenot0.41604532
98MP0001919_abnormal_reproductive_system0.41577896
99MP0003795_abnormal_bone_structure0.41402414
100MP0003045_fibrosis0.41152625

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.92359686
2T lymphocytopenia (HP:0005403)6.19551670
3Eczematoid dermatitis (HP:0000976)6.00359549
4Abnormality of T cell number (HP:0011839)5.84675461
5Severe combined immunodeficiency (HP:0004430)5.61231106
6Stomatitis (HP:0010280)5.38693080
7Panhypogammaglobulinemia (HP:0003139)4.99693439
8Abnormality of T cells (HP:0002843)4.80548416
9Abnormality of macrophages (HP:0004311)4.74217977
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.60555170
11Recurrent fungal infections (HP:0002841)4.58949403
12Myositis (HP:0100614)4.53677002
13Autoimmune hemolytic anemia (HP:0001890)4.47473166
14Combined immunodeficiency (HP:0005387)4.44509009
15Recurrent abscess formation (HP:0002722)4.37924237
16Recurrent bacterial skin infections (HP:0005406)4.34925280
17Chronic mucocutaneous candidiasis (HP:0002728)4.19598660
18Recurrent cutaneous fungal infections (HP:0011370)4.19598660
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.90594046
20Encephalitis (HP:0002383)3.86437589
21Orchitis (HP:0100796)3.82777810
22Gastrointestinal infarctions (HP:0005244)3.80580512
23Retrobulbar optic neuritis (HP:0100654)3.76277386
24Optic neuritis (HP:0100653)3.76277386
25Pustule (HP:0200039)3.64594844
26Recurrent viral infections (HP:0004429)3.62431800
27Aplastic anemia (HP:0001915)3.60829795
28Recurrent skin infections (HP:0001581)3.56852445
29Lymphopenia (HP:0001888)3.56381007
30IgG deficiency (HP:0004315)3.55831569
31Abnormality of T cell physiology (HP:0011840)3.54893320
32Leukocytosis (HP:0001974)3.50101925
33Meningitis (HP:0001287)3.42286695
34Abnormality of eosinophils (HP:0001879)3.40295498
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.36732625
36Colitis (HP:0002583)3.31047303
37Inflammation of the large intestine (HP:0002037)3.24752125
38Increased IgM level (HP:0003496)3.21111000
39Eosinophilia (HP:0001880)3.15551985
40Agammaglobulinemia (HP:0004432)3.12220550
41Vasculitis (HP:0002633)3.10755058
42Hypochromic microcytic anemia (HP:0004840)3.09002772
43Thyroiditis (HP:0100646)3.08977912
44Granulocytopenia (HP:0001913)3.06151444
45Gastrointestinal inflammation (HP:0004386)3.05862721
46Recurrent gram-negative bacterial infections (HP:0005420)3.02081580
47Spontaneous hematomas (HP:0007420)2.97704501
48Increased IgE level (HP:0003212)2.96986749
49Mediastinal lymphadenopathy (HP:0100721)2.93570591
50Hypoplasia of the thymus (HP:0000778)2.89179498
51Obstructive lung disease (HP:0006536)2.88389636
52Chronic obstructive pulmonary disease (HP:0006510)2.88389636
53Chest pain (HP:0100749)2.84515516
54Microcytic anemia (HP:0001935)2.83022983
55Hypochromic anemia (HP:0001931)2.81993841
56IgM deficiency (HP:0002850)2.81825868
57Keratoconjunctivitis sicca (HP:0001097)2.76041141
58Hypergammaglobulinemia (HP:0010702)2.74045420
59Autoimmune thrombocytopenia (HP:0001973)2.71837100
60Chronic diarrhea (HP:0002028)2.67102994
61Recurrent bronchitis (HP:0002837)2.60545384
62Keratoconjunctivitis (HP:0001096)2.56930226
63Abnormal rod and cone electroretinograms (HP:0008323)2.51120296
64Pulmonary infiltrates (HP:0002113)2.50898288
65Prolonged bleeding time (HP:0003010)2.46523901
66Anorexia (HP:0002039)2.34995112
67Slow saccadic eye movements (HP:0000514)2.34772129
683-Methylglutaconic aciduria (HP:0003535)2.34731263
69Joint swelling (HP:0001386)2.33074769
70Hemoptysis (HP:0002105)2.32883564
71Hypoproteinemia (HP:0003075)2.29058616
72Gingival bleeding (HP:0000225)2.24627440
73Urticaria (HP:0001025)2.22944968
74Lymphoma (HP:0002665)2.22574391
75Gangrene (HP:0100758)2.09767873
76Epistaxis (HP:0000421)2.09678224
77Sepsis (HP:0100806)2.06898260
78Pulmonary embolism (HP:0002204)2.02893296
79Gonadal dysgenesis (HP:0000133)2.02594483
80Segmental peripheral demyelination/remyelination (HP:0003481)2.02078917
81Gingivitis (HP:0000230)2.00898684
82Episodic fever (HP:0001954)1.98875326
83B lymphocytopenia (HP:0010976)1.98277456
84Hyperlipoproteinemia (HP:0010980)1.92961391
85Abnormality of the fingertips (HP:0001211)1.92927632
86Petechiae (HP:0000967)1.92799974
87Arterial thrombosis (HP:0004420)1.92570334
88Abnormality of the pleura (HP:0002103)1.91983163
89Abnormality of B cell number (HP:0010975)1.89720527
90Viral hepatitis (HP:0006562)1.89402719
91Acute hepatic failure (HP:0006554)1.85993259
92Alveolar cell carcinoma (HP:0006519)1.83856510
93Verrucae (HP:0200043)1.79795551
94Papilloma (HP:0012740)1.79795551
95Papilledema (HP:0001085)1.77957738
96Constricted visual fields (HP:0001133)1.77693128
97Increased serum ferritin (HP:0003281)1.71528196
98Congenital stationary night blindness (HP:0007642)1.69939246
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.69580766
100Neoplasm of the tracheobronchial system (HP:0100552)1.68607825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.61160562
2MAP4K14.47700810
3TNK23.46527203
4FES3.37820099
5KDR2.88637083
6PRPF4B2.84119553
7TESK22.82204011
8RIPK42.70254896
9CSK2.67633878
10BCKDK2.50244570
11ITK2.48752706
12ZAP702.44908836
13TEC2.27516636
14GRK62.13565392
15IRAK42.13269810
16BTK2.08992411
17SIK32.02281319
18TAOK31.94524746
19TYK21.88741528
20LCK1.80775576
21TAOK21.78682456
22SYK1.68750127
23HCK1.57093487
24JAK31.48330644
25PRKCQ1.48028035
26CDK191.46774020
27LYN1.40492142
28IKBKE1.39498242
29JAK11.39404476
30BLK1.35863145
31MAP3K111.31684098
32BMX1.20070985
33MELK1.16884147
34MARK31.15906606
35MAP2K31.13041048
36SIK21.12253221
37NLK1.11659922
38TESK11.09345042
39CSF1R1.08903942
40FGR1.07049949
41EPHB11.06266817
42TAOK11.01676220
43ADRBK21.01662096
44RPS6KA40.98105452
45MAP3K10.96055982
46MAP3K30.93865742
47ERN10.93551615
48PASK0.90991023
49JAK20.90250850
50LRRK20.89510911
51SCYL20.87468911
52GRK70.81862777
53TBK10.80697913
54STK100.73868651
55MAP3K140.70578503
56PIM10.69801843
57PINK10.67612436
58KSR20.67525448
59FYN0.66825918
60RAF10.66694375
61PTK60.66550674
62CAMKK20.63622262
63TYRO30.61192728
64SIK10.58646334
65IKBKB0.58041493
66PAK40.57953514
67CAMKK10.56910375
68CDC42BPA0.56520246
69MAP3K120.55367368
70TLK10.54983899
71MAPK110.52628103
72STK380.52379911
73PRKCH0.49160309
74FGFR30.47102797
75KIT0.44617357
76INSR0.42906690
77BRSK10.40121478
78SMG10.39943601
79MAPK120.39829040
80HIPK20.38489078
81PDK10.36484177
82ABL10.35969887
83MAPKAPK20.33378383
84FGFR40.30522370
85IRAK10.28746835
86RPS6KA50.28229512
87PDGFRB0.27248377
88VRK20.27230233
89PIK3CG0.27002485
90PTK2B0.26744563
91IRAK20.26642570
92EGFR0.24727582
93IGF1R0.23998867
94PRKD20.23505746
95MAP2K70.22128821
96TGFBR20.18914549
97PAK30.16880894
98YES10.15053204
99CDK40.14968990
100STK40.14786818

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.88409340
2T cell receptor signaling pathway_Homo sapiens_hsa046603.89588012
3Graft-versus-host disease_Homo sapiens_hsa053323.52910392
4Allograft rejection_Homo sapiens_hsa053303.33430616
5Autoimmune thyroid disease_Homo sapiens_hsa053203.28479756
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.21190780
7Hematopoietic cell lineage_Homo sapiens_hsa046402.68979906
8Type I diabetes mellitus_Homo sapiens_hsa049402.57003222
9Measles_Homo sapiens_hsa051622.50260575
10Antigen processing and presentation_Homo sapiens_hsa046122.45279095
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16659121
12Osteoclast differentiation_Homo sapiens_hsa043801.97278873
13Viral myocarditis_Homo sapiens_hsa054161.84924863
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.83093300
15B cell receptor signaling pathway_Homo sapiens_hsa046621.75676989
16Leishmaniasis_Homo sapiens_hsa051401.71904583
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.71120677
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.70129279
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60758180
20Staphylococcus aureus infection_Homo sapiens_hsa051501.51581500
21Malaria_Homo sapiens_hsa051441.50552338
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41824638
23Herpes simplex infection_Homo sapiens_hsa051681.36456277
24Chemokine signaling pathway_Homo sapiens_hsa040621.35792889
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34785286
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34548995
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31229214
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29324222
29Asthma_Homo sapiens_hsa053101.24058789
30Tuberculosis_Homo sapiens_hsa051521.21461278
31Ribosome_Homo sapiens_hsa030101.16666144
32TNF signaling pathway_Homo sapiens_hsa046681.12954077
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10715242
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08951425
35Acute myeloid leukemia_Homo sapiens_hsa052211.08373096
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03948392
37Apoptosis_Homo sapiens_hsa042101.01158873
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.97228476
39Rheumatoid arthritis_Homo sapiens_hsa053230.93561962
40HTLV-I infection_Homo sapiens_hsa051660.91542145
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90467761
42Pancreatic cancer_Homo sapiens_hsa052120.87318111
43Shigellosis_Homo sapiens_hsa051310.86387018
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85968104
45Platelet activation_Homo sapiens_hsa046110.85873994
46Toxoplasmosis_Homo sapiens_hsa051450.84786917
47African trypanosomiasis_Homo sapiens_hsa051430.83915956
48Legionellosis_Homo sapiens_hsa051340.83505664
49Hepatitis B_Homo sapiens_hsa051610.79318897
50Influenza A_Homo sapiens_hsa051640.78849938
51VEGF signaling pathway_Homo sapiens_hsa043700.76578176
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76105396
53Viral carcinogenesis_Homo sapiens_hsa052030.72944883
54Non-small cell lung cancer_Homo sapiens_hsa052230.72604868
55Epstein-Barr virus infection_Homo sapiens_hsa051690.69152517
56Endocytosis_Homo sapiens_hsa041440.67829829
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67391535
58Pertussis_Homo sapiens_hsa051330.64812812
59Phagosome_Homo sapiens_hsa041450.63010085
60Colorectal cancer_Homo sapiens_hsa052100.60052016
61FoxO signaling pathway_Homo sapiens_hsa040680.57884508
62Regulation of autophagy_Homo sapiens_hsa041400.55846979
63Prolactin signaling pathway_Homo sapiens_hsa049170.55258890
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.54785296
65Proteasome_Homo sapiens_hsa030500.51960813
66Salmonella infection_Homo sapiens_hsa051320.51578337
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.50777026
68Hepatitis C_Homo sapiens_hsa051600.46579391
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43971177
70Oxidative phosphorylation_Homo sapiens_hsa001900.40191002
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40088518
72MAPK signaling pathway_Homo sapiens_hsa040100.39425743
73Rap1 signaling pathway_Homo sapiens_hsa040150.38553259
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37949278
75Collecting duct acid secretion_Homo sapiens_hsa049660.37766197
76Endometrial cancer_Homo sapiens_hsa052130.37664165
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36917305
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36691292
79Chronic myeloid leukemia_Homo sapiens_hsa052200.36412032
80Insulin resistance_Homo sapiens_hsa049310.35938537
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.33946530
82Alzheimers disease_Homo sapiens_hsa050100.31853801
83Parkinsons disease_Homo sapiens_hsa050120.31026971
84Phototransduction_Homo sapiens_hsa047440.30618440
85Sulfur metabolism_Homo sapiens_hsa009200.30589774
86Ras signaling pathway_Homo sapiens_hsa040140.29879368
87Renal cell carcinoma_Homo sapiens_hsa052110.29215186
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29097679
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24585493
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24233173
91Choline metabolism in cancer_Homo sapiens_hsa052310.23606635
92Systemic lupus erythematosus_Homo sapiens_hsa053220.22616605
93Dorso-ventral axis formation_Homo sapiens_hsa043200.21017510
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.20638681
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18857208
96ErbB signaling pathway_Homo sapiens_hsa040120.18590631
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18499865
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.16583151
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16174118
100Thyroid cancer_Homo sapiens_hsa052160.15312709

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