TRAV1-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.48921057
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.48921057
3positive regulation of gamma-delta T cell activation (GO:0046645)6.79169698
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.74703364
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.59913274
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.24416094
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.20102765
8antigen processing and presentation of endogenous antigen (GO:0019883)6.14631794
9cellular response to interleukin-15 (GO:0071350)6.12038298
10negative T cell selection (GO:0043383)6.09668690
11response to interleukin-15 (GO:0070672)6.08167742
12negative thymic T cell selection (GO:0045060)5.82336926
13regulation of B cell receptor signaling pathway (GO:0050855)5.61845765
14regulation of gamma-delta T cell differentiation (GO:0045586)5.57946039
15regulation of gamma-delta T cell activation (GO:0046643)5.36619111
16negative regulation of T cell mediated immunity (GO:0002710)5.12606936
17tolerance induction (GO:0002507)5.07232229
18negative regulation of lymphocyte mediated immunity (GO:0002707)4.84044382
19activated T cell proliferation (GO:0050798)4.62953228
20positive T cell selection (GO:0043368)4.62391263
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.62333023
22regulation of T cell tolerance induction (GO:0002664)4.61879981
23leukocyte aggregation (GO:0070486)4.55670580
24T cell selection (GO:0045058)4.53829801
25thymic T cell selection (GO:0045061)4.50595946
26regulation of regulatory T cell differentiation (GO:0045589)4.46296720
27T cell migration (GO:0072678)4.43003699
28positive thymic T cell selection (GO:0045059)4.18224805
29regulation of isotype switching to IgG isotypes (GO:0048302)4.14413591
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.13969029
31regulation of natural killer cell mediated immunity (GO:0002715)4.13969029
32modulation by symbiont of host immune response (GO:0052553)4.13901769
33positive regulation by symbiont of host defense response (GO:0052509)4.13901769
34modulation by symbiont of host defense response (GO:0052031)4.13901769
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13901769
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13901769
37positive regulation by organism of defense response of other organism involved in symbiotic interact4.13901769
38negative regulation of leukocyte mediated immunity (GO:0002704)4.09034531
39regulation of alpha-beta T cell proliferation (GO:0046640)4.08624678
40positive regulation of tolerance induction (GO:0002645)4.04789188
41regulation of tolerance induction (GO:0002643)4.03883857
42regulation of B cell differentiation (GO:0045577)3.97888710
43positive regulation of granulocyte differentiation (GO:0030854)3.90433311
44positive regulation of B cell differentiation (GO:0045579)3.89688038
45interferon-gamma production (GO:0032609)3.84182197
46regulation of T cell mediated cytotoxicity (GO:0001914)3.83639059
47detection of other organism (GO:0098543)3.81006288
48detection of bacterium (GO:0016045)3.80346051
49negative regulation of interleukin-12 production (GO:0032695)3.72682365
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.65852627
51antigen processing and presentation via MHC class Ib (GO:0002475)3.59979764
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.59483586
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.57808440
54T cell receptor signaling pathway (GO:0050852)3.57750542
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.55076520
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54684087
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.54602430
58positive regulation of T cell differentiation in thymus (GO:0033089)3.53164730
59neutrophil activation involved in immune response (GO:0002283)3.52449522
60positive regulation of natural killer cell mediated immunity (GO:0002717)3.51718762
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.51535596
62negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.51496949
63positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48069311
64antigen receptor-mediated signaling pathway (GO:0050851)3.48017175
65T cell homeostasis (GO:0043029)3.47610340
66type I interferon signaling pathway (GO:0060337)3.47176520
67cellular response to type I interferon (GO:0071357)3.47176520
68response to type I interferon (GO:0034340)3.43840250
69cellular extravasation (GO:0045123)3.43597685
70B cell receptor signaling pathway (GO:0050853)3.39558460
71negative regulation of adaptive immune response (GO:0002820)3.39125164
72dendritic cell chemotaxis (GO:0002407)3.35729279
73regulation of cell killing (GO:0031341)3.28919999
74mast cell activation (GO:0045576)3.28199387
75positive regulation of humoral immune response (GO:0002922)3.21022578
76positive regulation of cell killing (GO:0031343)3.20662657
77dendritic cell migration (GO:0036336)3.19241529
78alpha-beta T cell differentiation (GO:0046632)3.14934782
79regulation of isotype switching (GO:0045191)3.13889487
80respiratory burst (GO:0045730)3.09647517
81neutrophil activation (GO:0042119)3.07743402
82macrophage activation involved in immune response (GO:0002281)3.07613158
83positive regulation of isotype switching (GO:0045830)3.07607882
84positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.06096995
85negative regulation of B cell mediated immunity (GO:0002713)3.06091265
86negative regulation of immunoglobulin mediated immune response (GO:0002890)3.06091265
87NIK/NF-kappaB signaling (GO:0038061)3.01723368
88regulation of T cell mediated immunity (GO:0002709)3.00433751
89negative regulation of type 2 immune response (GO:0002829)2.99126104
90positive regulation of interleukin-2 production (GO:0032743)2.97050136
91detection of external biotic stimulus (GO:0098581)2.93731825
92alpha-beta T cell activation (GO:0046631)2.92349862
93negative regulation of T-helper cell differentiation (GO:0045623)2.91925453
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91925453
95positive regulation of B cell mediated immunity (GO:0002714)2.91921630
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.91921630
97leukocyte degranulation (GO:0043299)2.91148808
98negative regulation of cytokine production involved in immune response (GO:0002719)2.89405790
99regulation of interferon-beta biosynthetic process (GO:0045357)2.88673363
100lymphocyte migration (GO:0072676)2.88430649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.47733447
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.46169740
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.16494990
4RUNX_20019798_ChIP-Seq_JUKART_Human3.81034620
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.71744565
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.62834615
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62597741
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.43325397
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.35278263
10MYB_26560356_Chip-Seq_TH2_Human3.35191594
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28877808
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.01641388
13MAF_26560356_Chip-Seq_TH1_Human2.97426171
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93652356
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88564713
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76693594
17MYB_26560356_Chip-Seq_TH1_Human2.73722257
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.56370013
19UTX_26944678_Chip-Seq_JUKART_Human2.54650120
20MYC_22102868_ChIP-Seq_BL_Human2.52557486
21SPI1_23547873_ChIP-Seq_NB4_Human2.47817456
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43486950
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43469685
24GATA3_27048872_Chip-Seq_THYMUS_Human2.31797012
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31213704
26MAF_26560356_Chip-Seq_TH2_Human2.17190529
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.13490874
28SCL_19346495_ChIP-Seq_HPC-7_Human2.10875950
29VDR_21846776_ChIP-Seq_THP-1_Human2.06333912
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.05430116
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05167727
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00980811
33SPI1_23127762_ChIP-Seq_K562_Human1.99278444
34TCF7_22412390_ChIP-Seq_EML_Mouse1.91006508
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90078694
36VDR_24763502_ChIP-Seq_THP-1_Human1.89355458
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.84480592
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82090447
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81906267
40GATA3_26560356_Chip-Seq_TH2_Human1.79237863
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78487230
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.75399094
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.74464303
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72176129
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65956369
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65448474
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56637380
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53574719
49KDM2B_26808549_Chip-Seq_DND41_Human1.53092865
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52076136
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46293316
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44674625
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44302653
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35079668
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34167481
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.32596337
57CIITA_25753668_ChIP-Seq_RAJI_Human1.31216004
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27875932
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27853352
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24738218
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24011866
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23587938
63PU_27001747_Chip-Seq_BMDM_Mouse1.23141736
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22058926
65VDR_24787735_ChIP-Seq_THP-1_Human1.16652303
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15802887
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15335815
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.15121290
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14009552
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12974933
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10020076
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09680980
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08514592
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07872367
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06064299
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02841920
77GATA1_22025678_ChIP-Seq_K562_Human1.00644631
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98822383
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.97973036
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97575294
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95277503
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93568540
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92392924
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90079495
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89525203
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89459091
87VDR_23849224_ChIP-Seq_CD4+_Human0.86993141
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86913662
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86677353
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82336433
91NCOR1_26117541_ChIP-Seq_K562_Human0.79375142
92GATA1_19941826_ChIP-Seq_K562_Human0.78535819
93GATA3_26560356_Chip-Seq_TH1_Human0.78012465
94FOXP3_21729870_ChIP-Seq_TREG_Human0.77511043
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76831181
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76435044
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75679482
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75634306
99GATA2_19941826_ChIP-Seq_K562_Human0.73846349
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71209336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.48304849
2MP0005671_abnormal_response_to4.25497060
3MP0003436_decreased_susceptibility_to4.19961571
4MP0001835_abnormal_antigen_presentation3.97609645
5MP0003724_increased_susceptibility_to3.55878399
6MP0001800_abnormal_humoral_immune3.36894217
7MP0005000_abnormal_immune_tolerance3.17857565
8MP0001790_abnormal_immune_system2.94028789
9MP0005387_immune_system_phenotype2.94028789
10MP0000685_abnormal_immune_system2.92620432
11MP0009785_altered_susceptibility_to2.88737871
12MP0009333_abnormal_splenocyte_physiolog2.87472655
13MP0002723_abnormal_immune_serum2.83916549
14MP0002420_abnormal_adaptive_immunity2.79014075
15MP0005025_abnormal_response_to2.78283079
16MP0001819_abnormal_immune_cell2.74384405
17MP0003303_peritoneal_inflammation2.61146740
18MP0002452_abnormal_antigen_presenting2.59932507
19MP0002419_abnormal_innate_immunity2.54907780
20MP0002405_respiratory_system_inflammati2.50446056
21MP0006082_CNS_inflammation2.47351879
22MP0002398_abnormal_bone_marrow2.47084714
23MP0003300_gastrointestinal_ulcer2.44021336
24MP0000703_abnormal_thymus_morphology2.38794918
25MP0003866_abnormal_defecation2.32220627
26MP0002148_abnormal_hypersensitivity_rea2.30931296
27MP0000716_abnormal_immune_system2.24496087
28MP0004381_abnormal_hair_follicle2.22383933
29MP0001873_stomach_inflammation2.12311385
30MP0010155_abnormal_intestine_physiology2.11413321
31MP0000689_abnormal_spleen_morphology2.00981724
32MP0002722_abnormal_immune_system1.97416853
33MP0002277_abnormal_respiratory_mucosa1.84666465
34MP0001533_abnormal_skeleton_physiology1.81944689
35MP0004947_skin_inflammation1.79398496
36MP0002429_abnormal_blood_cell1.76206943
37MP0002166_altered_tumor_susceptibility1.74035472
38MP0005464_abnormal_platelet_physiology1.72823537
39MP0001845_abnormal_inflammatory_respons1.71599467
40MP0002396_abnormal_hematopoietic_system1.61251863
41MP0005310_abnormal_salivary_gland1.60119280
42MP0000465_gastrointestinal_hemorrhage1.57488686
43MP0002132_abnormal_respiratory_system1.41770197
44MP0001851_eye_inflammation1.41083001
45MP0008469_abnormal_protein_level1.25919342
46MP0001853_heart_inflammation1.25085202
47MP0005075_abnormal_melanosome_morpholog1.25059167
48MP0008260_abnormal_autophagy1.17495402
49MP0003828_pulmonary_edema1.17036098
50MP0001348_abnormal_lacrimal_gland1.12415436
51MP0003191_abnormal_cellular_cholesterol1.12091244
52MP0002006_tumorigenesis1.10982267
53MP0008057_abnormal_DNA_replication1.07702230
54MP0000858_altered_metastatic_potential1.05029273
55MP0009764_decreased_sensitivity_to1.04068379
56MP0003172_abnormal_lysosome_physiology1.03181601
57MP0004883_abnormal_blood_vessel1.02349986
58MP0003045_fibrosis1.01540789
59MP0000490_abnormal_crypts_of1.00899006
60MP0004808_abnormal_hematopoietic_stem0.99468539
61MP0002163_abnormal_gland_morphology0.99054211
62MP0002998_abnormal_bone_remodeling0.98707161
63MP0004510_myositis0.93526407
64MP0002138_abnormal_hepatobiliary_system0.93185941
65MP0002933_joint_inflammation0.92404274
66MP0002009_preneoplasia0.91953263
67MP0001663_abnormal_digestive_system0.90839814
68MP0009763_increased_sensitivity_to0.81124284
69MP0005451_abnormal_body_composition0.80156577
70MP0009278_abnormal_bone_marrow0.79655927
71MP0005390_skeleton_phenotype0.74444394
72MP0003448_altered_tumor_morphology0.74103453
73MP0002019_abnormal_tumor_incidence0.71044088
74MP0005166_decreased_susceptibility_to0.67475561
75MP0003795_abnormal_bone_structure0.65551296
76MP0000015_abnormal_ear_pigmentation0.62056732
77MP0005164_abnormal_response_to0.60192105
78MP0005397_hematopoietic_system_phenotyp0.59380837
79MP0001545_abnormal_hematopoietic_system0.59380837
80MP0003690_abnormal_glial_cell0.57922509
81MP0001986_abnormal_taste_sensitivity0.57805136
82MP0002693_abnormal_pancreas_physiology0.57676897
83MP0000604_amyloidosis0.57570569
84MP0004130_abnormal_muscle_cell0.56123608
85MP0003221_abnormal_cardiomyocyte_apopto0.55656012
86MP0009765_abnormal_xenobiotic_induced0.53581527
87MP0003183_abnormal_peptide_metabolism0.53182143
88MP0000249_abnormal_blood_vessel0.50918668
89MP0003091_abnormal_cell_migration0.48511092
90MP0003075_altered_response_to0.48063840
91MP0005381_digestive/alimentary_phenotyp0.45231783
92MP0008961_abnormal_basal_metabolism0.43576096
93MP0000609_abnormal_liver_physiology0.41221293
94MP0003806_abnormal_nucleotide_metabolis0.39150126
95MP0008873_increased_physiological_sensi0.38354086
96MP0008874_decreased_physiological_sensi0.37328171
97MP0004142_abnormal_muscle_tone0.36344064
98MP0005379_endocrine/exocrine_gland_phen0.35639121
99MP0001765_abnormal_ion_homeostasis0.35519607
100MP0001919_abnormal_reproductive_system0.35183027

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.62925507
2T lymphocytopenia (HP:0005403)6.30061666
3Elevated erythrocyte sedimentation rate (HP:0003565)6.13903181
4Abnormality of T cell number (HP:0011839)5.91293526
5Eczematoid dermatitis (HP:0000976)5.87914900
6Myositis (HP:0100614)5.29717116
7Recurrent bacterial skin infections (HP:0005406)4.79324506
8Recurrent abscess formation (HP:0002722)4.74664007
9Orchitis (HP:0100796)4.69581138
10Retrobulbar optic neuritis (HP:0100654)4.64454420
11Optic neuritis (HP:0100653)4.64454420
12Abnormality of T cells (HP:0002843)4.58174304
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.45333152
14Recurrent fungal infections (HP:0002841)4.38749432
15Abnormality of macrophages (HP:0004311)4.25140592
16Gastrointestinal infarctions (HP:0005244)4.21822333
17Autoimmune hemolytic anemia (HP:0001890)4.15430344
18Meningitis (HP:0001287)3.85857506
19Increased IgM level (HP:0003496)3.84992091
20Severe combined immunodeficiency (HP:0004430)3.83661420
21Encephalitis (HP:0002383)3.82647032
22Mediastinal lymphadenopathy (HP:0100721)3.78784243
23Chronic mucocutaneous candidiasis (HP:0002728)3.76640178
24Recurrent cutaneous fungal infections (HP:0011370)3.76640178
25Obstructive lung disease (HP:0006536)3.67076124
26Chronic obstructive pulmonary disease (HP:0006510)3.67076124
27Spontaneous hematomas (HP:0007420)3.66281399
28Vasculitis (HP:0002633)3.56814130
29Recurrent skin infections (HP:0001581)3.55406561
30Hypochromic microcytic anemia (HP:0004840)3.51361200
31Pulmonary infiltrates (HP:0002113)3.50737124
32Leukocytosis (HP:0001974)3.44537810
33Keratoconjunctivitis sicca (HP:0001097)3.42640588
34Recurrent bronchitis (HP:0002837)3.37658755
35Recurrent viral infections (HP:0004429)3.35300236
36Recurrent gram-negative bacterial infections (HP:0005420)3.35007239
37Abnormality of eosinophils (HP:0001879)3.25959632
38IgG deficiency (HP:0004315)3.25227132
39Abnormality of T cell physiology (HP:0011840)3.25040920
40Keratoconjunctivitis (HP:0001096)3.24785109
41Pustule (HP:0200039)3.24128963
42Hypochromic anemia (HP:0001931)3.21782948
43Chest pain (HP:0100749)3.21270633
44Increased IgE level (HP:0003212)3.10418179
45Panhypogammaglobulinemia (HP:0003139)3.08825635
46Gingivitis (HP:0000230)3.03485146
47Prolonged bleeding time (HP:0003010)3.03189935
48Combined immunodeficiency (HP:0005387)3.01611651
49Granulocytopenia (HP:0001913)3.01463968
50Hemoptysis (HP:0002105)2.94259368
51Lymphopenia (HP:0001888)2.92881789
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.83175765
53Eosinophilia (HP:0001880)2.82546209
54IgM deficiency (HP:0002850)2.77967648
55Chronic diarrhea (HP:0002028)2.77189461
56Anorexia (HP:0002039)2.74035625
57Urticaria (HP:0001025)2.72821062
58Inflammation of the large intestine (HP:0002037)2.66785274
59Pulmonary embolism (HP:0002204)2.66006540
60Microcytic anemia (HP:0001935)2.65670200
61Chronic otitis media (HP:0000389)2.64805115
62Epistaxis (HP:0000421)2.64752655
63Hypergammaglobulinemia (HP:0010702)2.61944702
64Gastrointestinal inflammation (HP:0004386)2.59596434
65Gingival bleeding (HP:0000225)2.58583041
66Arterial thrombosis (HP:0004420)2.57247202
67Nasal polyposis (HP:0100582)2.50450369
68Gangrene (HP:0100758)2.49118124
69Agammaglobulinemia (HP:0004432)2.45959972
70Thyroiditis (HP:0100646)2.45397905
71Joint swelling (HP:0001386)2.43123924
72Episodic fever (HP:0001954)2.33721211
73Papilledema (HP:0001085)2.33546521
74Cellulitis (HP:0100658)2.32577404
75Abnormality of the fingertips (HP:0001211)2.32315180
76Sepsis (HP:0100806)2.30884479
77Lymphoma (HP:0002665)2.27842260
78Abnormality of the pleura (HP:0002103)2.27181776
79Petechiae (HP:0000967)2.24462140
80Verrucae (HP:0200043)2.19822032
81Papilloma (HP:0012740)2.19822032
82Acute hepatic failure (HP:0006554)2.16871935
83Slow saccadic eye movements (HP:0000514)2.16298952
84Glomerulopathy (HP:0100820)2.15701305
85Hypoplasia of the thymus (HP:0000778)2.15222220
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09856499
87Osteomyelitis (HP:0002754)2.05136449
88Keratitis (HP:0000491)2.02698106
89Bronchitis (HP:0012387)2.02287981
90Skin ulcer (HP:0200042)2.01584002
91Colitis (HP:0002583)2.01410898
92Abnormality of the nasal mucosa (HP:0000433)1.99840229
93Polyneuropathy (HP:0001271)1.98295517
94Fatigue (HP:0012378)1.96423316
95Basal cell carcinoma (HP:0002671)1.91989543
96Autoimmune thrombocytopenia (HP:0001973)1.88876393
97Skin rash (HP:0000988)1.88036954
98Abnormal platelet volume (HP:0011876)1.87997926
99Amaurosis fugax (HP:0100576)1.83495284
100Abnormality of the pericardium (HP:0001697)1.79863469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.74124711
2TXK4.09992365
3RIPK43.75206569
4FES2.90144942
5TYK22.72413225
6CSK2.61116841
7ITK2.30430564
8BTK2.25325255
9JAK32.20244454
10ZAP702.18704706
11TAOK32.18554335
12SIK32.16814922
13PRPF4B2.11421833
14MAP2K32.08231654
15JAK12.06293743
16GRK62.03987338
17IRAK41.93380723
18TEC1.82242469
19EPHB11.80784045
20HCK1.76845476
21IKBKE1.71188846
22BLK1.67739451
23TNK21.67736821
24SYK1.66723274
25LCK1.64517556
26MAP3K131.61513911
27FGFR41.55412417
28MAP3K141.55380405
29TAOK11.46006003
30STK101.45694798
31NLK1.44089884
32MAP3K31.36063510
33MARK31.35483459
34ERN11.32966835
35CAMKK21.32666818
36JAK21.29437781
37LYN1.27659795
38FGFR31.18307084
39SIK21.09604709
40PASK1.09530905
41IKBKB1.09141657
42MAP3K111.07914605
43HIPK21.05788454
44KSR21.03561570
45FGR0.99841414
46CAMKK10.98669985
47MAP3K10.97972613
48PRKCQ0.93662071
49TBK10.92804567
50LRRK20.90997300
51TYRO30.90798725
52MST40.90102355
53YES10.89510302
54CSF1R0.88077751
55PDK10.85965451
56EPHA30.83945176
57TAOK20.83659090
58MARK20.79809091
59BMPR20.77898469
60PIK3CG0.74926594
61MAP3K100.68209100
62PIM10.67950081
63GRK70.66905962
64STK380.65236001
65FYN0.63205606
66CDK40.63139143
67KIT0.63024510
68MAPK120.60850991
69MAPK110.60826025
70DYRK1B0.60492245
71MAP3K70.59884111
72PTK60.58316816
73IRAK10.56757368
74TGFBR20.56193996
75CDK190.55466331
76SIK10.53726536
77NEK60.51411008
78CHUK0.50451121
79RAF10.50240422
80SMG10.49815710
81MAP3K50.47812318
82PDGFRB0.46260170
83MAP3K20.45855962
84STK40.41331493
85PRKD20.40645044
86BRD40.39855771
87PRKCH0.39805028
88CDK120.39790225
89KSR10.39377610
90PDPK10.38861254
91STK110.38032441
92MAPK70.37998960
93TRIB30.37463490
94SGK30.34538796
95MAP3K80.34246185
96MAP2K60.32720366
97RET0.32145411
98MAP3K120.31972477
99CDK60.30454098
100CLK10.29731621

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.23009755
2T cell receptor signaling pathway_Homo sapiens_hsa046603.12216237
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.98815798
4Allograft rejection_Homo sapiens_hsa053302.78203913
5Graft-versus-host disease_Homo sapiens_hsa053322.74873153
6Autoimmune thyroid disease_Homo sapiens_hsa053202.69214335
7Osteoclast differentiation_Homo sapiens_hsa043802.51604294
8Measles_Homo sapiens_hsa051622.50086056
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23093761
10Leishmaniasis_Homo sapiens_hsa051402.19120223
11B cell receptor signaling pathway_Homo sapiens_hsa046622.12571496
12Antigen processing and presentation_Homo sapiens_hsa046122.08648896
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.98812889
14Type I diabetes mellitus_Homo sapiens_hsa049401.96647463
15Hematopoietic cell lineage_Homo sapiens_hsa046401.92848258
16Acute myeloid leukemia_Homo sapiens_hsa052211.90120107
17Viral myocarditis_Homo sapiens_hsa054161.79854020
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.76374557
19Chemokine signaling pathway_Homo sapiens_hsa040621.74520045
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70280135
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68218659
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67006890
23Staphylococcus aureus infection_Homo sapiens_hsa051501.63589941
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62948630
25Herpes simplex infection_Homo sapiens_hsa051681.62397369
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61353416
27Malaria_Homo sapiens_hsa051441.60207433
28Tuberculosis_Homo sapiens_hsa051521.51564476
29Non-small cell lung cancer_Homo sapiens_hsa052231.45494580
30Toxoplasmosis_Homo sapiens_hsa051451.40723966
31Hepatitis B_Homo sapiens_hsa051611.36767255
32Influenza A_Homo sapiens_hsa051641.33036223
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.30683196
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30543816
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28496245
36TNF signaling pathway_Homo sapiens_hsa046681.25773161
37Legionellosis_Homo sapiens_hsa051341.23030252
38Pancreatic cancer_Homo sapiens_hsa052121.20668101
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.18862736
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11462786
41Platelet activation_Homo sapiens_hsa046111.10299609
42Viral carcinogenesis_Homo sapiens_hsa052031.09882976
43Asthma_Homo sapiens_hsa053101.08688196
44Hepatitis C_Homo sapiens_hsa051601.05556683
45Apoptosis_Homo sapiens_hsa042101.03913994
46Chronic myeloid leukemia_Homo sapiens_hsa052201.03639643
47VEGF signaling pathway_Homo sapiens_hsa043700.99101680
48Prolactin signaling pathway_Homo sapiens_hsa049170.98384942
49African trypanosomiasis_Homo sapiens_hsa051430.97737788
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93676749
51Epstein-Barr virus infection_Homo sapiens_hsa051690.93398523
52Shigellosis_Homo sapiens_hsa051310.92623680
53FoxO signaling pathway_Homo sapiens_hsa040680.92182301
54HTLV-I infection_Homo sapiens_hsa051660.87311386
55Colorectal cancer_Homo sapiens_hsa052100.83759621
56Renal cell carcinoma_Homo sapiens_hsa052110.80991092
57Endometrial cancer_Homo sapiens_hsa052130.78213040
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77252512
59Endocytosis_Homo sapiens_hsa041440.74825274
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.73949225
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70790260
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.68600289
63Phagosome_Homo sapiens_hsa041450.67502703
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65818567
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64399334
66Regulation of autophagy_Homo sapiens_hsa041400.64271546
67Pertussis_Homo sapiens_hsa051330.57915839
68Salmonella infection_Homo sapiens_hsa051320.57844874
69MAPK signaling pathway_Homo sapiens_hsa040100.57401442
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57250900
71Thyroid cancer_Homo sapiens_hsa052160.57101761
72mTOR signaling pathway_Homo sapiens_hsa041500.56596355
73Inositol phosphate metabolism_Homo sapiens_hsa005620.56574102
74Rheumatoid arthritis_Homo sapiens_hsa053230.55820083
75Choline metabolism in cancer_Homo sapiens_hsa052310.55181369
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.54166418
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49859869
78Prostate cancer_Homo sapiens_hsa052150.48192346
79Notch signaling pathway_Homo sapiens_hsa043300.47145348
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46914911
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45763890
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.45693212
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45569735
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44521089
85Dorso-ventral axis formation_Homo sapiens_hsa043200.43980255
86Insulin resistance_Homo sapiens_hsa049310.43310395
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43094064
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41285778
89Long-term potentiation_Homo sapiens_hsa047200.39344047
90ErbB signaling pathway_Homo sapiens_hsa040120.37954477
91HIF-1 signaling pathway_Homo sapiens_hsa040660.34859630
92Glioma_Homo sapiens_hsa052140.34816365
93Rap1 signaling pathway_Homo sapiens_hsa040150.34638970
94Other glycan degradation_Homo sapiens_hsa005110.33154362
95Ras signaling pathway_Homo sapiens_hsa040140.32973914
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30517282
97Type II diabetes mellitus_Homo sapiens_hsa049300.29786158
98GnRH signaling pathway_Homo sapiens_hsa049120.27839031
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24786154
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24698919

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