TRAPPC6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.42002805
2DNA deamination (GO:0045006)6.77133251
3viral transcription (GO:0019083)5.70549925
4translational termination (GO:0006415)5.48547174
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.04255786
6purine deoxyribonucleotide catabolic process (GO:0009155)5.00549423
7cotranslational protein targeting to membrane (GO:0006613)4.88835091
8translational elongation (GO:0006414)4.88600833
9protein targeting to ER (GO:0045047)4.88574691
10ribosomal small subunit biogenesis (GO:0042274)4.83847744
11deoxyribonucleotide catabolic process (GO:0009264)4.82707114
12deoxyribose phosphate catabolic process (GO:0046386)4.71933448
13protein localization to endoplasmic reticulum (GO:0070972)4.63191185
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.61880519
15viral life cycle (GO:0019058)4.32788451
16protein complex biogenesis (GO:0070271)4.20279107
17maturation of SSU-rRNA (GO:0030490)4.17466523
18pyrimidine nucleotide catabolic process (GO:0006244)4.15294383
19cellular protein complex disassembly (GO:0043624)4.15229507
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14781677
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.12730707
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12302461
23ATP synthesis coupled proton transport (GO:0015986)4.12302461
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08584043
25translational initiation (GO:0006413)4.07784082
26negative regulation of B cell apoptotic process (GO:0002903)3.94504624
27mitochondrial respiratory chain complex assembly (GO:0033108)3.84956340
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.82642938
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82642938
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80212530
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.80212530
32NADH dehydrogenase complex assembly (GO:0010257)3.80212530
33base-excision repair, AP site formation (GO:0006285)3.78980322
34deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.77160408
35purine nucleotide salvage (GO:0032261)3.75704920
36purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.74273435
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.71616271
38purine deoxyribonucleotide metabolic process (GO:0009151)3.71470769
392-deoxyribonucleotide metabolic process (GO:0009394)3.71018326
40pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.70461473
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69628829
42antigen processing and presentation via MHC class Ib (GO:0002475)3.68363437
43protein complex disassembly (GO:0043241)3.63385040
44ribosomal large subunit biogenesis (GO:0042273)3.61592189
45deoxyribose phosphate metabolic process (GO:0019692)3.59254406
46telomere maintenance via semi-conservative replication (GO:0032201)3.58840368
47respiratory electron transport chain (GO:0022904)3.55631476
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54840518
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54840518
50regulation of mitochondrial translation (GO:0070129)3.53888170
51electron transport chain (GO:0022900)3.51508078
52platelet dense granule organization (GO:0060155)3.42618861
53macromolecular complex disassembly (GO:0032984)3.41997960
54response to interferon-beta (GO:0035456)3.37998526
55translation (GO:0006412)3.36440896
56antigen processing and presentation of endogenous antigen (GO:0019883)3.27618007
57chaperone-mediated protein transport (GO:0072321)3.24566689
58rRNA modification (GO:0000154)3.23817236
59positive regulation of B cell differentiation (GO:0045579)3.23696437
60DNA strand elongation involved in DNA replication (GO:0006271)3.23653854
61protein targeting to membrane (GO:0006612)3.17902255
62negative regulation of erythrocyte differentiation (GO:0045647)3.14866513
63regulation of B cell apoptotic process (GO:0002902)3.14576927
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.13802191
65DNA strand elongation (GO:0022616)3.12623899
66establishment of protein localization to mitochondrial membrane (GO:0090151)3.08425515
67telomere maintenance via recombination (GO:0000722)3.07863231
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07135022
69endosome to pigment granule transport (GO:0043485)3.04191791
70endosome to melanosome transport (GO:0035646)3.04191791
71ribonucleoprotein complex biogenesis (GO:0022613)3.04051434
72deoxyribonucleotide metabolic process (GO:0009262)3.03615876
73formation of translation preinitiation complex (GO:0001731)3.02744681
74mRNA catabolic process (GO:0006402)3.00807962
75pseudouridine synthesis (GO:0001522)3.00535764
76positive regulation of prostaglandin secretion (GO:0032308)2.99432499
77immunoglobulin mediated immune response (GO:0016064)2.98013590
78nucleotide salvage (GO:0043173)2.97634304
79branched-chain amino acid catabolic process (GO:0009083)2.96857640
80mannosylation (GO:0097502)2.96247873
81proteasome assembly (GO:0043248)2.91950265
82regulation of cellular amino acid metabolic process (GO:0006521)2.87330316
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87151014
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83914182
85RNA catabolic process (GO:0006401)2.82263248
86purine-containing compound salvage (GO:0043101)2.76487417
87protein targeting to mitochondrion (GO:0006626)2.74276748
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71081588
89branched-chain amino acid metabolic process (GO:0009081)2.68766938
90metallo-sulfur cluster assembly (GO:0031163)2.68165795
91iron-sulfur cluster assembly (GO:0016226)2.68165795
92negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.67295292
93autophagic vacuole fusion (GO:0000046)2.65735416
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65688902
95respiratory chain complex IV assembly (GO:0008535)2.65492231
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64863008
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64863008
98GDP-mannose metabolic process (GO:0019673)2.63393201
99telomere maintenance via telomere lengthening (GO:0010833)2.63277357
100mitotic recombination (GO:0006312)2.63228860
101B cell mediated immunity (GO:0019724)2.59750583
102DNA replication initiation (GO:0006270)2.59092875
103establishment of protein localization to mitochondrion (GO:0072655)2.58302164
104definitive hemopoiesis (GO:0060216)2.58029671
105rRNA processing (GO:0006364)2.56744675
106glyoxylate metabolic process (GO:0046487)2.56113214
107deoxyribose phosphate biosynthetic process (GO:0046385)2.56038199
1082-deoxyribonucleotide biosynthetic process (GO:0009265)2.56038199
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55523854
110protein neddylation (GO:0045116)2.54417661
111oxidative phosphorylation (GO:0006119)2.53531126
112pentose-phosphate shunt (GO:0006098)2.53030647
113signal transduction involved in DNA damage checkpoint (GO:0072422)2.51356690
114signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51356690
115cellular component biogenesis (GO:0044085)2.51242726
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51029649
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51022202
118negative regulation of ligase activity (GO:0051352)2.51022202
119heme biosynthetic process (GO:0006783)2.49843596
120signal peptide processing (GO:0006465)2.48748812
121response to interferon-alpha (GO:0035455)2.47613226
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46047050
123rRNA metabolic process (GO:0016072)2.45698538
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44720205
125regulation of necrotic cell death (GO:0010939)2.44515833
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.44234803
127regulation of B cell differentiation (GO:0045577)2.43280210
128positive regulation of gamma-delta T cell activation (GO:0046645)2.42335819
129regulation of necroptotic process (GO:0060544)2.42076516
130negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38176179
131response to protozoan (GO:0001562)2.37233738
132defense response to protozoan (GO:0042832)2.37028983
133polyketide metabolic process (GO:0030638)2.36360269
134doxorubicin metabolic process (GO:0044598)2.36360269
135daunorubicin metabolic process (GO:0044597)2.36360269
136cellular response to interferon-beta (GO:0035458)2.33684620
137response to type I interferon (GO:0034340)2.33318770
138granulocyte differentiation (GO:0030851)2.31684318
139DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.31657043
140type I interferon signaling pathway (GO:0060337)2.31047563
141cellular response to type I interferon (GO:0071357)2.31047563
142pteridine-containing compound biosynthetic process (GO:0042559)2.29781279
143L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29389245
144regulation of erythrocyte differentiation (GO:0045646)2.28653028
145negative regulation of phagocytosis (GO:0050765)2.28557514
146cytochrome complex assembly (GO:0017004)2.27718509
147nucleoside salvage (GO:0043174)2.27189131
148intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.26606948
149signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.26606948
150mature B cell differentiation involved in immune response (GO:0002313)2.25814390
151pentose metabolic process (GO:0019321)2.25778410
152negative regulation of viral entry into host cell (GO:0046597)2.25047795
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.24528190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.11958726
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75558240
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.18675021
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89824800
5SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.72458549
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.64597750
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.60406698
8* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57649320
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56734432
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47204562
11* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.42162184
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40115610
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39729616
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.38881786
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.38775796
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37819195
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.29002624
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24466708
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23612107
20SCL_19346495_ChIP-Seq_HPC-7_Human2.23276894
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20208103
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15563179
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13100488
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11707777
25VDR_23849224_ChIP-Seq_CD4+_Human2.03541481
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95404216
27VDR_21846776_ChIP-Seq_THP-1_Human1.94020391
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92420184
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91530510
30* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88723867
31XRN2_22483619_ChIP-Seq_HELA_Human1.83426836
32* SRF_21415370_ChIP-Seq_HL-1_Mouse1.80039987
33* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78748367
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78662956
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76645238
36MYC_22102868_ChIP-Seq_BL_Human1.75881275
37SPI1_23547873_ChIP-Seq_NB4_Human1.75305041
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75156678
39* FOXP3_21729870_ChIP-Seq_TREG_Human1.74295681
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.66626396
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66159045
42DCP1A_22483619_ChIP-Seq_HELA_Human1.63642194
43GABP_19822575_ChIP-Seq_HepG2_Human1.63337974
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63227980
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61114118
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60944299
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60814955
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60632202
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60014241
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.57053201
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57027673
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.55661171
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54663914
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.48943497
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.45608873
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45507316
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.38499031
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38431509
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38251844
60VDR_24763502_ChIP-Seq_THP-1_Human1.37565566
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36922962
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36809504
63TTF2_22483619_ChIP-Seq_HELA_Human1.36476138
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36067185
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34159664
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33157780
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32846542
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32693915
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31009029
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30329531
71CIITA_25753668_ChIP-Seq_RAJI_Human1.29926236
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28615192
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27048712
74MAF_26560356_Chip-Seq_TH1_Human1.26330603
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.25308605
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25137628
77GATA1_22025678_ChIP-Seq_K562_Human1.23954332
78ELK1_19687146_ChIP-ChIP_HELA_Human1.23029633
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21761847
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21644042
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19158348
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18972967
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.18789619
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.17974192
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17705035
86MYB_26560356_Chip-Seq_TH2_Human1.17031682
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16215402
88KDM5A_27292631_Chip-Seq_BREAST_Human1.16179856
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14863993
90BCOR_27268052_Chip-Seq_Bcells_Human1.14547133
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.13813069
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12994259
93UTX_26944678_Chip-Seq_JUKART_Human1.11776961
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10323924
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08800900
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.08796079
97* MYC_18940864_ChIP-ChIP_HL60_Human1.08794263
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08406897
99MYB_26560356_Chip-Seq_TH1_Human1.08145295
100P68_20966046_ChIP-Seq_HELA_Human1.07583950
101MAF_26560356_Chip-Seq_TH2_Human1.06747188
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05820940
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04858795
104P300_27268052_Chip-Seq_Bcells_Human1.04490138
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02396416
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.01649727
107E2F1_20622854_ChIP-Seq_HELA_Human1.00986549
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00709395
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00508881
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00394730
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00316294
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99359025
113MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99245789
114SPI1_20517297_ChIP-Seq_HL60_Human0.98709879
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98424799
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98218876
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97775930
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97707324
119PHF8_20622854_ChIP-Seq_HELA_Human0.97306166
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.96971809
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95862812
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95271357
123NANOG_20526341_ChIP-Seq_ESCs_Human0.94548052
124STAT1_20625510_ChIP-Seq_HELA_Human0.94446936
125CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93292075
126BCL6_27268052_Chip-Seq_Bcells_Human0.93270723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.23490924
2MP0009785_altered_susceptibility_to2.90575561
3MP0002396_abnormal_hematopoietic_system2.83804262
4MP0003693_abnormal_embryo_hatching2.77924997
5MP0000685_abnormal_immune_system2.72538519
6MP0005671_abnormal_response_to2.60172004
7MP0003436_decreased_susceptibility_to2.49149013
8MP0006292_abnormal_olfactory_placode2.48249323
9MP0000490_abnormal_crypts_of2.42899849
10MP0002148_abnormal_hypersensitivity_rea2.32209747
11MP0005025_abnormal_response_to2.25002236
12MP0001545_abnormal_hematopoietic_system2.20500481
13MP0005397_hematopoietic_system_phenotyp2.20500481
14MP0009379_abnormal_foot_pigmentation2.14706788
15MP0003763_abnormal_thymus_physiology2.13983120
16MP0001873_stomach_inflammation2.11100147
17MP0003724_increased_susceptibility_to2.06613857
18MP0003186_abnormal_redox_activity2.00345089
19MP0003866_abnormal_defecation1.99886244
20MP0005464_abnormal_platelet_physiology1.98747181
21MP0002132_abnormal_respiratory_system1.96281582
22MP0003806_abnormal_nucleotide_metabolis1.95701057
23MP0009333_abnormal_splenocyte_physiolog1.94548967
24MP0001800_abnormal_humoral_immune1.94019606
25MP0005000_abnormal_immune_tolerance1.93174754
26MP0010155_abnormal_intestine_physiology1.90367457
27MP0002398_abnormal_bone_marrow1.87218110
28MP0002420_abnormal_adaptive_immunity1.85514481
29MP0005174_abnormal_tail_pigmentation1.85104366
30MP0001819_abnormal_immune_cell1.83959811
31MP0002452_abnormal_antigen_presenting1.83750966
32MP0002723_abnormal_immune_serum1.81250651
33MP0002166_altered_tumor_susceptibility1.72120701
34MP0002419_abnormal_innate_immunity1.71008333
35MP0002653_abnormal_ependyma_morphology1.70545365
36MP0000689_abnormal_spleen_morphology1.66731692
37MP0004808_abnormal_hematopoietic_stem1.64853611
38MP0002722_abnormal_immune_system1.64612419
39MP0001853_heart_inflammation1.63424629
40MP0004957_abnormal_blastocyst_morpholog1.63127796
41MP0000716_abnormal_immune_system1.62710672
42MP0008877_abnormal_DNA_methylation1.62017891
43MP0003656_abnormal_erythrocyte_physiolo1.61524092
44MP0005387_immune_system_phenotype1.61298180
45MP0001790_abnormal_immune_system1.61298180
46MP0002429_abnormal_blood_cell1.59756465
47MP0006054_spinal_hemorrhage1.59683373
48MP0005645_abnormal_hypothalamus_physiol1.59318060
49MP0002405_respiratory_system_inflammati1.52661331
50MP0010094_abnormal_chromosome_stability1.50884585
51MP0008007_abnormal_cellular_replicative1.49313466
52MP0008058_abnormal_DNA_repair1.47231514
53MP0003077_abnormal_cell_cycle1.46593055
54MP0000465_gastrointestinal_hemorrhage1.44955961
55MP0005646_abnormal_pituitary_gland1.43295641
56MP0006035_abnormal_mitochondrial_morpho1.42575245
57MP0002006_tumorigenesis1.42547925
58MP0008875_abnormal_xenobiotic_pharmacok1.41664423
59MP0009840_abnormal_foam_cell1.41407337
60MP0009697_abnormal_copulation1.40839349
61MP0001845_abnormal_inflammatory_respons1.40823852
62* MP0005075_abnormal_melanosome_morpholog1.38543825
63MP0004147_increased_porphyrin_level1.35882292
64MP0003303_peritoneal_inflammation1.34704311
65MP0008469_abnormal_protein_level1.34484957
66MP0006036_abnormal_mitochondrial_physio1.33881069
67MP0002163_abnormal_gland_morphology1.32230075
68MP0002095_abnormal_skin_pigmentation1.30740148
69MP0008995_early_reproductive_senescence1.28365249
70MP0003787_abnormal_imprinting1.22679483
71MP0001764_abnormal_homeostasis1.21563951
72MP0002019_abnormal_tumor_incidence1.19647978
73MP0002138_abnormal_hepatobiliary_system1.19183285
74MP0003111_abnormal_nucleus_morphology1.18854311
75MP0005410_abnormal_fertilization1.12922722
76MP0000858_altered_metastatic_potential1.12655012
77MP0003011_delayed_dark_adaptation1.12154430
78MP0008872_abnormal_physiological_respon1.11888751
79MP0000703_abnormal_thymus_morphology1.11672165
80MP0002837_dystrophic_cardiac_calcinosis1.10245710
81MP0008789_abnormal_olfactory_epithelium1.10149917
82MP0001663_abnormal_digestive_system1.10003923
83MP0006082_CNS_inflammation1.05051587
84MP0003300_gastrointestinal_ulcer1.05047770
85MP0002277_abnormal_respiratory_mucosa1.04155303
86MP0001905_abnormal_dopamine_level1.03589028
87MP0003786_premature_aging1.02780422
88MP0000313_abnormal_cell_death1.01089491
89MP0001533_abnormal_skeleton_physiology1.00662827
90MP0002139_abnormal_hepatobiliary_system1.00134506
91MP0004947_skin_inflammation0.99686262
92MP0000343_altered_response_to0.99183990
93MP0010352_gastrointestinal_tract_polyps0.98218489
94MP0005220_abnormal_exocrine_pancreas0.98197731
95MP0009765_abnormal_xenobiotic_induced0.96869049
96* MP0000372_irregular_coat_pigmentation0.96807632
97MP0005058_abnormal_lysosome_morphology0.96628300
98MP0001968_abnormal_touch/_nociception0.96339718
99MP0000477_abnormal_intestine_morphology0.95122611
100MP0003718_maternal_effect0.95034501
101MP0005379_endocrine/exocrine_gland_phen0.94910045
102MP0003646_muscle_fatigue0.94067890
103MP0000015_abnormal_ear_pigmentation0.93439455
104MP0002736_abnormal_nociception_after0.92924749
105MP0003191_abnormal_cellular_cholesterol0.92072493
106MP0001986_abnormal_taste_sensitivity0.91623537
107MP0003075_altered_response_to0.88601666
108MP0005636_abnormal_mineral_homeostasis0.86705516
109MP0009764_decreased_sensitivity_to0.85612442
110MP0001293_anophthalmia0.85267808
111MP0003172_abnormal_lysosome_physiology0.83952960
112MP0005319_abnormal_enzyme/_coenzyme0.83326111
113MP0000358_abnormal_cell_content/0.79821995
114MP0009643_abnormal_urine_homeostasis0.78938498
115MP0002933_joint_inflammation0.78047019
116MP0005310_abnormal_salivary_gland0.77862323
117MP0005377_hearing/vestibular/ear_phenot0.76481909
118MP0003878_abnormal_ear_physiology0.76481909
119MP0005499_abnormal_olfactory_system0.75401187
120MP0005394_taste/olfaction_phenotype0.75401187
121MP0003315_abnormal_perineum_morphology0.73654655
122MP0000598_abnormal_liver_morphology0.72752825
123MP0004782_abnormal_surfactant_physiolog0.71784612
124MP0009763_increased_sensitivity_to0.71351683
125MP0008057_abnormal_DNA_replication0.70450660
126MP0003943_abnormal_hepatobiliary_system0.70174237
127MP0002877_abnormal_melanocyte_morpholog0.69434789
128MP0005023_abnormal_wound_healing0.67743903
129MP0000681_abnormal_thyroid_gland0.65663663
130MP0005584_abnormal_enzyme/coenzyme_acti0.64215531
131MP0005084_abnormal_gallbladder_morpholo0.63814565
132MP0009278_abnormal_bone_marrow0.63235204
133MP0000371_diluted_coat_color0.62378055
134MP0005381_digestive/alimentary_phenotyp0.61638502

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.85828164
2Abnormal number of erythroid precursors (HP:0012131)5.73440762
3Aplastic anemia (HP:0001915)5.23559858
4Thrombocytosis (HP:0001894)4.50037042
5Acute necrotizing encephalopathy (HP:0006965)4.48276932
6Abnormal mitochondria in muscle tissue (HP:0008316)4.42497835
7Reticulocytopenia (HP:0001896)4.33990141
8Acute encephalopathy (HP:0006846)4.32282337
9Petechiae (HP:0000967)4.19151064
10Reduced antithrombin III activity (HP:0001976)4.00502707
11Type I transferrin isoform profile (HP:0003642)3.79227237
12IgM deficiency (HP:0002850)3.59846835
13Elevated erythrocyte sedimentation rate (HP:0003565)3.54889296
14Progressive macrocephaly (HP:0004481)3.54503274
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.43003405
16Pallor (HP:0000980)3.34568963
17Agammaglobulinemia (HP:0004432)3.25622225
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.24292891
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.24292891
20Cerebral edema (HP:0002181)3.10544869
21Macrocytic anemia (HP:0001972)3.08176408
22Abnormal protein glycosylation (HP:0012346)3.07428796
23Abnormal glycosylation (HP:0012345)3.07428796
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.07428796
25Abnormal protein N-linked glycosylation (HP:0012347)3.07428796
26Recurrent abscess formation (HP:0002722)2.96447649
27Prolonged bleeding time (HP:0003010)2.94640277
28Chronic otitis media (HP:0000389)2.85006830
29Exertional dyspnea (HP:0002875)2.78150548
30Microretrognathia (HP:0000308)2.72716358
31Recurrent bacterial skin infections (HP:0005406)2.70454225
32Hepatic necrosis (HP:0002605)2.69863011
33Myositis (HP:0100614)2.69279474
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69155370
35Cerebral palsy (HP:0100021)2.68420630
36Hepatocellular necrosis (HP:0001404)2.65592242
373-Methylglutaconic aciduria (HP:0003535)2.63751559
38Obstructive lung disease (HP:0006536)2.60804149
39Chronic obstructive pulmonary disease (HP:0006510)2.60804149
40Abnormality of T cell physiology (HP:0011840)2.59787895
41Severe combined immunodeficiency (HP:0004430)2.58678499
42Epistaxis (HP:0000421)2.55122502
43Increased intramyocellular lipid droplets (HP:0012240)2.54371415
44Respiratory failure (HP:0002878)2.54086587
45Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50974079
46Hyperglycinemia (HP:0002154)2.50806117
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49458368
48Increased muscle lipid content (HP:0009058)2.48727945
49Abnormal platelet function (HP:0011869)2.46777133
50Impaired platelet aggregation (HP:0003540)2.46777133
51Oral leukoplakia (HP:0002745)2.46469079
52Increased hepatocellular lipid droplets (HP:0006565)2.41324801
53Vacuolated lymphocytes (HP:0001922)2.40079195
54Increased IgM level (HP:0003496)2.39907651
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37521643
56Lipid accumulation in hepatocytes (HP:0006561)2.36551428
57Pancytopenia (HP:0001876)2.34157440
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32235268
59Eczematoid dermatitis (HP:0000976)2.30371101
60Optic disc pallor (HP:0000543)2.29270268
61Abnormality of macrophages (HP:0004311)2.28320296
62Muscle fiber atrophy (HP:0100295)2.24948563
63Stomatitis (HP:0010280)2.24603088
64Lethargy (HP:0001254)2.24496579
65Microcytic anemia (HP:0001935)2.24164685
66Abnormality of B cell number (HP:0010975)2.23422299
67B lymphocytopenia (HP:0010976)2.23422299
68Hyperglycinuria (HP:0003108)2.22955902
69Recurrent bronchitis (HP:0002837)2.22658220
70Abnormality of the nasal mucosa (HP:0000433)2.21134262
71Combined immunodeficiency (HP:0005387)2.19477989
72Mitochondrial inheritance (HP:0001427)2.18627524
73Increased serum lactate (HP:0002151)2.18409271
74Generalized aminoaciduria (HP:0002909)2.17175146
75Nasal polyposis (HP:0100582)2.17094552
76Interstitial pulmonary disease (HP:0006530)2.16564142
77Poor head control (HP:0002421)2.14994107
78Methylmalonic aciduria (HP:0012120)2.14537321
79Emotional lability (HP:0000712)2.13995622
80Abnormality of reticulocytes (HP:0004312)2.13006330
81Type 2 muscle fiber atrophy (HP:0003554)2.10935114
82Neutropenia (HP:0001875)2.09872001
83Renal Fanconi syndrome (HP:0001994)2.07744991
84Poikiloderma (HP:0001029)2.07542139
85Severe visual impairment (HP:0001141)2.05585096
86Increased CSF lactate (HP:0002490)2.04624234
87Pulmonary fibrosis (HP:0002206)2.03909377
88Progressive microcephaly (HP:0000253)2.03521180
89Abnormality of renal resorption (HP:0011038)2.02370090
90Lymphoma (HP:0002665)2.00365348
91Recurrent skin infections (HP:0001581)1.96767650
92Gastrointestinal inflammation (HP:0004386)1.96731973
9311 pairs of ribs (HP:0000878)1.95706120
94Abnormality of serine family amino acid metabolism (HP:0010894)1.95575381
95Abnormality of glycine metabolism (HP:0010895)1.95575381
96Abnormality of T cells (HP:0002843)1.95166376
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.94827488
98Methylmalonic acidemia (HP:0002912)1.93785317
99Purpura (HP:0000979)1.93576163
100Increased serum ferritin (HP:0003281)1.93325309
101Inflammation of the large intestine (HP:0002037)1.92400513
102Recurrent fungal infections (HP:0002841)1.92048812
103Albinism (HP:0001022)1.91624904
104CNS demyelination (HP:0007305)1.90577819
105Recurrent viral infections (HP:0004429)1.89779927
106Abnormal rod and cone electroretinograms (HP:0008323)1.89557897
107Meningitis (HP:0001287)1.89017498
108Hypertensive crisis (HP:0100735)1.87824000
109Polycythemia (HP:0001901)1.87393907
110Abnormality of the prostate (HP:0008775)1.86926386
111Gingival bleeding (HP:0000225)1.86864395
112Congenital stationary night blindness (HP:0007642)1.86203714
113Prostate neoplasm (HP:0100787)1.86038480
114Colon cancer (HP:0003003)1.85431064
115Myelodysplasia (HP:0002863)1.83938048
116Pustule (HP:0200039)1.83846418
117Cellulitis (HP:0100658)1.82968921
118Panhypogammaglobulinemia (HP:0003139)1.82831192
119Decreased central vision (HP:0007663)1.82035486
120Microvesicular hepatic steatosis (HP:0001414)1.82003807
121Amaurosis fugax (HP:0100576)1.81822757
122Abolished electroretinogram (ERG) (HP:0000550)1.81103081
123Beaking of vertebral bodies (HP:0004568)1.81078450
124Respiratory difficulties (HP:0002880)1.80710081
125Ragged-red muscle fibers (HP:0003200)1.79588807
126Mediastinal lymphadenopathy (HP:0100721)1.79365799
127Abnormality of male internal genitalia (HP:0000022)1.78378532
128Chronic mucocutaneous candidiasis (HP:0002728)1.78347928
129Recurrent cutaneous fungal infections (HP:0011370)1.78347928
130Vasculitis (HP:0002633)1.76881026
131Lactic acidosis (HP:0003128)1.76648470
132IgG deficiency (HP:0004315)1.76186777
133Granulocytopenia (HP:0001913)1.75139261
134Opisthotonus (HP:0002179)1.74672383
135Ketosis (HP:0001946)1.74535928
136Abnormality of cells of the lymphoid lineage (HP:0012140)1.74348868
137Encephalitis (HP:0002383)1.71819157
138Lymphopenia (HP:0001888)1.70808098
139Multiple enchondromatosis (HP:0005701)1.70785152
140Dicarboxylic aciduria (HP:0003215)1.69835127
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69835127
142Exercise intolerance (HP:0003546)1.68384987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.70499810
2NME24.19806542
3PIM22.82164662
4MAP4K12.63093296
5STK162.51189711
6MAP4K22.51050970
7TBK12.48195251
8TEC2.27866178
9FLT32.25362442
10KIT2.18699097
11NUAK12.18451294
12TIE12.13915186
13BTK1.90568729
14EIF2AK31.86167037
15BCKDK1.82879301
16KDR1.81505914
17MAPKAPK31.71902745
18WEE11.70102511
19IKBKE1.69114136
20ZAP701.68891221
21EEF2K1.66992433
22BLK1.63959644
23TGFBR11.62412343
24BUB11.61640754
25EIF2AK11.61023699
26TNK21.54869210
27ACVR1B1.52849674
28JAK31.52823645
29MUSK1.49635331
30MAP2K31.49106096
31RPS6KB21.47706686
32IKBKB1.45327681
33ERN11.41472593
34PKN21.40142402
35FES1.37074372
36VRK11.34944471
37MAP3K111.34568953
38TYK21.28349547
39IRAK41.24752635
40NEK21.20081992
41RIPK41.20053092
42TXK1.16635559
43PIM11.14675499
44LRRK21.13851523
45SCYL21.12194175
46ITK1.10465087
47DYRK31.09798382
48CSF1R1.09296269
49CDK191.07454687
50NLK1.06494811
51DAPK11.06300164
52TLK11.06058249
53ADRBK21.05926334
54DYRK21.02510555
55SYK1.01539948
56PASK0.95366218
57GRK10.94373590
58TGFBR20.93349446
59TRIB30.92121376
60RPS6KA50.90936564
61MST40.90861480
62MAP3K30.90727402
63RPS6KA40.89663713
64MATK0.88809406
65TESK10.88405638
66PRKCQ0.87942562
67CSNK1G30.87911740
68MYLK0.87297320
69PRKG20.85939520
70MAP3K140.85518606
71CDK70.84468876
72CDK80.83694221
73ILK0.82765523
74LYN0.80803216
75TAF10.79184987
76MAP2K20.78637312
77MST1R0.77067243
78TESK20.70463362
79DAPK30.69838410
80MAPKAPK50.69084406
81TAOK30.67170251
82AURKB0.66774859
83MKNK10.66231427
84BMPR1B0.65997490
85PBK0.65834733
86CDK40.65264044
87PAK40.65128981
88MAP3K120.64119655
89IRAK30.63624438
90TNIK0.62182592
91NME10.61311426
92RAF10.60861722
93LCK0.59798540
94MAP3K80.59640482
95STK40.59319162
96AURKA0.59191826
97SRPK10.59120806
98MAP2K60.58971617
99CDC70.58551284
100ARAF0.58429104
101TAOK20.58134723
102PINK10.57589427
103BMPR20.57457833
104CSNK1G20.57302161
105ZAK0.56179037
106CSNK1G10.56067422
107PIK3CA0.55195303
108INSRR0.54625974
109ATR0.54194556
110EIF2AK20.53811442
111MAPK110.51752213
112BRSK20.50187747
113CSNK2A20.49558902
114ABL20.49529497
115PLK40.49292084
116NEK90.49104858
117MAPKAPK20.46757498
118CSNK1A1L0.46069841
119CHUK0.45925741
120STK100.45220065
121HCK0.45021577
122GRK60.43714343
123NEK10.42413134
124PLK10.42079333
125CSNK2A10.42065850
126CCNB10.41907447
127RPS6KA60.41823121
128CHEK20.40715357
129BRAF0.40655753
130PRKCD0.37883672
131WNK30.35479747
132CSNK1A10.34692482
133LIMK10.33413425
134OXSR10.31004319
135GRK50.30901537
136SMG10.30455436
137PRKCI0.27032168
138MAPK130.26135513

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.06361842
2DNA replication_Homo sapiens_hsa030303.88510986
3Mismatch repair_Homo sapiens_hsa034302.69970398
4Proteasome_Homo sapiens_hsa030502.68226330
5Base excision repair_Homo sapiens_hsa034102.52897155
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26521036
7Pyrimidine metabolism_Homo sapiens_hsa002402.24454158
8Autoimmune thyroid disease_Homo sapiens_hsa053202.21583076
9Homologous recombination_Homo sapiens_hsa034402.15288114
10RNA polymerase_Homo sapiens_hsa030202.01175472
11Sulfur relay system_Homo sapiens_hsa041221.88921372
12Protein export_Homo sapiens_hsa030601.86432353
13Type I diabetes mellitus_Homo sapiens_hsa049401.80130761
14Spliceosome_Homo sapiens_hsa030401.73301260
15Nucleotide excision repair_Homo sapiens_hsa034201.70569171
16Folate biosynthesis_Homo sapiens_hsa007901.69454759
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60293141
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58126725
19Pentose phosphate pathway_Homo sapiens_hsa000301.54164049
20Primary immunodeficiency_Homo sapiens_hsa053401.49790969
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48649939
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37783777
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34795220
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34688659
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32431473
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.32116746
27Parkinsons disease_Homo sapiens_hsa050121.28823975
28Fatty acid elongation_Homo sapiens_hsa000621.28244401
29Herpes simplex infection_Homo sapiens_hsa051681.27274559
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26523419
31Non-homologous end-joining_Homo sapiens_hsa034501.23457039
32N-Glycan biosynthesis_Homo sapiens_hsa005101.23292379
33Leishmaniasis_Homo sapiens_hsa051401.22671975
34RNA degradation_Homo sapiens_hsa030181.22120232
35One carbon pool by folate_Homo sapiens_hsa006701.22068944
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19763314
37Galactose metabolism_Homo sapiens_hsa000521.18748661
38Other glycan degradation_Homo sapiens_hsa005111.17267110
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.17012652
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16909846
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16231929
42Oxidative phosphorylation_Homo sapiens_hsa001901.12255235
43Staphylococcus aureus infection_Homo sapiens_hsa051501.12229453
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12217016
45Antigen processing and presentation_Homo sapiens_hsa046121.11774698
46Measles_Homo sapiens_hsa051621.10287577
47Hematopoietic cell lineage_Homo sapiens_hsa046401.08111436
48Purine metabolism_Homo sapiens_hsa002301.07968516
49Rheumatoid arthritis_Homo sapiens_hsa053231.07935750
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.05937688
51Fanconi anemia pathway_Homo sapiens_hsa034601.04800092
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04725408
53RNA transport_Homo sapiens_hsa030131.03558318
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02797192
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00156718
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00104052
57Legionellosis_Homo sapiens_hsa051340.99157466
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98354690
59p53 signaling pathway_Homo sapiens_hsa041150.94787690
60Propanoate metabolism_Homo sapiens_hsa006400.94512580
61Viral myocarditis_Homo sapiens_hsa054160.92463049
62Cell cycle_Homo sapiens_hsa041100.91793059
63Caffeine metabolism_Homo sapiens_hsa002320.90315119
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88842172
65Butanoate metabolism_Homo sapiens_hsa006500.87710843
66Basal transcription factors_Homo sapiens_hsa030220.87257409
67Allograft rejection_Homo sapiens_hsa053300.84961701
68Systemic lupus erythematosus_Homo sapiens_hsa053220.82747537
69Cardiac muscle contraction_Homo sapiens_hsa042600.81499712
70Fructose and mannose metabolism_Homo sapiens_hsa000510.81161459
71Huntingtons disease_Homo sapiens_hsa050160.79345873
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78527390
73Apoptosis_Homo sapiens_hsa042100.77796289
74Acute myeloid leukemia_Homo sapiens_hsa052210.76363063
75Glutathione metabolism_Homo sapiens_hsa004800.73545678
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.72441793
77Influenza A_Homo sapiens_hsa051640.70272106
78Asthma_Homo sapiens_hsa053100.70165540
79Epstein-Barr virus infection_Homo sapiens_hsa051690.69495122
80Selenocompound metabolism_Homo sapiens_hsa004500.68449246
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67537387
82Malaria_Homo sapiens_hsa051440.66865042
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66083408
84Pyruvate metabolism_Homo sapiens_hsa006200.65143309
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63290230
86B cell receptor signaling pathway_Homo sapiens_hsa046620.61616480
87Sulfur metabolism_Homo sapiens_hsa009200.61013146
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60825472
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60336720
90Pertussis_Homo sapiens_hsa051330.60017662
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58909072
92Shigellosis_Homo sapiens_hsa051310.57463613
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56996362
94Alzheimers disease_Homo sapiens_hsa050100.56898183
95Tryptophan metabolism_Homo sapiens_hsa003800.56800773
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56662001
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.56418467
98Thyroid cancer_Homo sapiens_hsa052160.55991408
99Arachidonic acid metabolism_Homo sapiens_hsa005900.55943402
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54703380
101Tyrosine metabolism_Homo sapiens_hsa003500.54117760
102Carbon metabolism_Homo sapiens_hsa012000.52491314
103Biosynthesis of amino acids_Homo sapiens_hsa012300.52006704
104Phototransduction_Homo sapiens_hsa047440.51244340
105Metabolic pathways_Homo sapiens_hsa011000.50900088
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.49898884
107Nitrogen metabolism_Homo sapiens_hsa009100.47571593
108Toxoplasmosis_Homo sapiens_hsa051450.47335087
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.46777551
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46596321
111Linoleic acid metabolism_Homo sapiens_hsa005910.45282105
112Hepatitis B_Homo sapiens_hsa051610.45151964
113Peroxisome_Homo sapiens_hsa041460.43312181
114Osteoclast differentiation_Homo sapiens_hsa043800.42002833
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41962180
116Viral carcinogenesis_Homo sapiens_hsa052030.41160987
117Regulation of autophagy_Homo sapiens_hsa041400.40546058
118Lysosome_Homo sapiens_hsa041420.40144076
119TNF signaling pathway_Homo sapiens_hsa046680.40109527
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39537833
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.38155654
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38130113
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.37633542
124Graft-versus-host disease_Homo sapiens_hsa053320.37518581
125Collecting duct acid secretion_Homo sapiens_hsa049660.36639902
126Tuberculosis_Homo sapiens_hsa051520.35308925
127Chemical carcinogenesis_Homo sapiens_hsa052040.35150223
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34812313
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34806525
130Fatty acid metabolism_Homo sapiens_hsa012120.32055954
131Fatty acid degradation_Homo sapiens_hsa000710.30622256
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.29858819
133Retinol metabolism_Homo sapiens_hsa008300.29109824

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