TRAPPC3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)8.49151717
2cell migration in hindbrain (GO:0021535)7.64994476
3detection of temperature stimulus (GO:0016048)7.63054459
4peripheral nervous system neuron development (GO:0048935)7.33512496
5detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.28011520
6detection of temperature stimulus involved in sensory perception (GO:0050961)7.28011520
7intermediate filament organization (GO:0045109)6.29127167
8calcium-mediated signaling using intracellular calcium source (GO:0035584)6.11522767
9regulation of memory T cell differentiation (GO:0043380)5.94284062
10negative regulation of homotypic cell-cell adhesion (GO:0034111)5.77349279
11neuronal action potential propagation (GO:0019227)5.57721191
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.54187104
13mitochondrion transport along microtubule (GO:0047497)5.54187104
14establishment of mitochondrion localization (GO:0051654)5.46785432
15negative regulation of dendrite development (GO:2000171)5.43500349
16indole-containing compound catabolic process (GO:0042436)5.31999882
17indolalkylamine catabolic process (GO:0046218)5.31999882
18tryptophan catabolic process (GO:0006569)5.31999882
19innervation (GO:0060384)5.14174080
20regulation of establishment of cell polarity (GO:2000114)5.05277719
21kynurenine metabolic process (GO:0070189)4.98740303
22indolalkylamine metabolic process (GO:0006586)4.84796846
23regulation of translational termination (GO:0006449)4.81656708
24axon development (GO:0061564)4.70629762
25tryptophan metabolic process (GO:0006568)4.52093981
26negative regulation of calcium ion transport into cytosol (GO:0010523)4.51846933
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.48470783
28response to acidic pH (GO:0010447)4.44615141
29negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.29183500
30regulation of establishment or maintenance of cell polarity (GO:0032878)4.21983759
31cytoplasmic mRNA processing body assembly (GO:0033962)4.21961917
32regulation of NFAT protein import into nucleus (GO:0051532)4.12846883
33intermediate filament cytoskeleton organization (GO:0045104)4.11696036
34intermediate filament-based process (GO:0045103)4.09829183
35positive regulation of axon extension (GO:0045773)4.07221032
36negative regulation of multicellular organism growth (GO:0040015)4.07022993
37inositol phosphate catabolic process (GO:0071545)4.07010677
38cellular biogenic amine catabolic process (GO:0042402)4.03731648
39amine catabolic process (GO:0009310)4.03731648
40sex differentiation (GO:0007548)4.03278310
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.02041844
42regulation of relaxation of muscle (GO:1901077)3.98097452
43regulation of sodium ion transmembrane transporter activity (GO:2000649)3.94143301
44neuron fate specification (GO:0048665)3.91329513
45regulation of platelet aggregation (GO:0090330)3.90734003
46neuronal action potential (GO:0019228)3.85998076
47protein K11-linked deubiquitination (GO:0035871)3.84992504
48detection of light stimulus involved in sensory perception (GO:0050962)3.84898439
49detection of light stimulus involved in visual perception (GO:0050908)3.84898439
50neural tube formation (GO:0001841)3.82302936
51regulation of protein heterodimerization activity (GO:0043497)3.81618617
52regulation of MHC class I biosynthetic process (GO:0045343)3.80647379
53membrane depolarization during action potential (GO:0086010)3.80479507
54negative regulation of mast cell activation (GO:0033004)3.79373735
55regulation of axon regeneration (GO:0048679)3.77137934
56regulation of neuron projection regeneration (GO:0070570)3.77137934
57positive regulation of vasculogenesis (GO:2001214)3.76930749
58regulation of cell maturation (GO:1903429)3.72177003
59neuromuscular process controlling posture (GO:0050884)3.68763595
60signal peptide processing (GO:0006465)3.68551275
61cranial nerve development (GO:0021545)3.64831080
62detection of mechanical stimulus involved in sensory perception (GO:0050974)3.63534295
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60440564
64regulation of cholesterol biosynthetic process (GO:0045540)3.57122146
65parturition (GO:0007567)3.56863328
66NAD biosynthetic process (GO:0009435)3.52042198
67organelle transport along microtubule (GO:0072384)3.51837680
68establishment of monopolar cell polarity (GO:0061162)3.47142813
69establishment or maintenance of monopolar cell polarity (GO:0061339)3.47142813
70axon cargo transport (GO:0008088)3.46630838
71indole-containing compound metabolic process (GO:0042430)3.46615255
72cilium or flagellum-dependent cell motility (GO:0001539)3.46461434
73serotonin receptor signaling pathway (GO:0007210)3.45846675
74regulation of membrane repolarization (GO:0060306)3.43711419
75aromatic amino acid family catabolic process (GO:0009074)3.42394877
76tachykinin receptor signaling pathway (GO:0007217)3.39766370
77membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.38800017
78L-fucose metabolic process (GO:0042354)3.38646161
79L-fucose catabolic process (GO:0042355)3.38646161
80fucose catabolic process (GO:0019317)3.38646161
81positive regulation of potassium ion transmembrane transport (GO:1901381)3.37878365
82photoreceptor cell maintenance (GO:0045494)3.35885794
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35361447
84synaptic vesicle maturation (GO:0016188)3.34958176
85proline transport (GO:0015824)3.34825541
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34520697
87positive regulation of sodium ion transport (GO:0010765)3.33047510
88enteric nervous system development (GO:0048484)3.30885996
89iron coordination entity transport (GO:1901678)3.29745236
90regulation of sarcomere organization (GO:0060297)3.29028214
91nerve development (GO:0021675)3.28379145
92protein neddylation (GO:0045116)3.27336031
93membrane budding (GO:0006900)3.26399801
94cellular ketone body metabolic process (GO:0046950)3.24773015
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22768754
96synaptic vesicle exocytosis (GO:0016079)3.20596902
97protein K63-linked deubiquitination (GO:0070536)3.20478485
98positive regulation of axonogenesis (GO:0050772)3.20164861
99regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20110853
100ADP metabolic process (GO:0046031)3.18254663
101monoubiquitinated protein deubiquitination (GO:0035520)3.15902233
102dopamine transport (GO:0015872)3.13818423
103benzene-containing compound metabolic process (GO:0042537)3.11528884
104thrombin receptor signaling pathway (GO:0070493)3.10496508
105negative regulation of striated muscle cell apoptotic process (GO:0010664)3.09094993
106cell communication involved in cardiac conduction (GO:0086065)3.07966943
107regulation of vasculogenesis (GO:2001212)3.07287299
108lipid translocation (GO:0034204)3.06906396
109phospholipid translocation (GO:0045332)3.06906396
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.06904045
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06196405
112axon regeneration (GO:0031103)3.05389990
113protein K48-linked deubiquitination (GO:0071108)3.05215893
114suckling behavior (GO:0001967)3.04521072
115negative regulation of microtubule polymerization (GO:0031115)3.04017717
116regulation of hippo signaling (GO:0035330)3.02644445
117sterol catabolic process (GO:0016127)3.02276657
118cholesterol catabolic process (GO:0006707)3.02276657
119glutamate secretion (GO:0014047)3.01451699
120reflex (GO:0060004)3.00718910
121mechanoreceptor differentiation (GO:0042490)3.00501997
122auditory receptor cell stereocilium organization (GO:0060088)3.00236074
123SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.99994481
124regulation of sodium ion transmembrane transport (GO:1902305)2.97077802
125protein localization to microtubule (GO:0035372)2.97048516
126positive regulation of potassium ion transport (GO:0043268)2.96782154
127membrane repolarization during action potential (GO:0086011)2.96762556
128regulation of synaptic vesicle exocytosis (GO:2000300)2.96385799
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.96077906
130positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.93490821
131positive regulation of actin cytoskeleton reorganization (GO:2000251)2.92654813
132aromatic amino acid family metabolic process (GO:0009072)2.92592950
133regulation of gene silencing by RNA (GO:0060966)2.92470386
134regulation of posttranscriptional gene silencing (GO:0060147)2.92470386
135regulation of gene silencing by miRNA (GO:0060964)2.92470386
136vesicle transport along microtubule (GO:0047496)2.90940831
137ventricular trabecula myocardium morphogenesis (GO:0003222)2.90461795
138ketone body metabolic process (GO:1902224)2.89798293
139regulation of MHC class II biosynthetic process (GO:0045346)2.89527479
140thyroid hormone metabolic process (GO:0042403)2.88632862
141cell communication by electrical coupling (GO:0010644)2.88537322
142retinal ganglion cell axon guidance (GO:0031290)2.87940919
143negative regulation of cation channel activity (GO:2001258)2.87629260
144positive regulation of mitochondrial fission (GO:0090141)2.87406909
145protein polyglutamylation (GO:0018095)2.86243597
146positive regulation of protein complex disassembly (GO:0043243)2.85887713
147acrosome assembly (GO:0001675)2.85700560
148regulation of axon extension (GO:0030516)2.84822635
149establishment of protein localization to Golgi (GO:0072600)2.83393432
150negative regulation of protein localization to cell surface (GO:2000009)2.83357248
151exploration behavior (GO:0035640)2.83201700
152negative regulation of potassium ion transmembrane transport (GO:1901380)2.82083880
153sulfation (GO:0051923)2.81836146
154acrosome reaction (GO:0007340)2.81791396
155negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.80573417
156response to corticosterone (GO:0051412)2.80547498
157gamma-aminobutyric acid transport (GO:0015812)2.80154727
158central nervous system neuron axonogenesis (GO:0021955)2.79483613
159interkinetic nuclear migration (GO:0022027)2.78887105
160positive regulation of developmental pigmentation (GO:0048087)2.78838700
161behavioral response to ethanol (GO:0048149)2.78638835
162regulation of pigment cell differentiation (GO:0050932)2.78390648
163adenosine metabolic process (GO:0046085)2.78362837
164activation of protein kinase B activity (GO:0032148)2.77340242
165regulation of cardiac muscle cell apoptotic process (GO:0010665)2.77306811
166cerebellar Purkinje cell differentiation (GO:0021702)2.77188784
167plasma membrane repair (GO:0001778)2.76628883
168regulation of microtubule-based movement (GO:0060632)2.75755067
169action potential (GO:0001508)2.75241078
170centrosome duplication (GO:0051298)2.74784186
171positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74186272
172positive regulation of cAMP-mediated signaling (GO:0043950)2.73551959
173sphingoid metabolic process (GO:0046519)2.71118328
174amino acid salvage (GO:0043102)2.70374464
175L-methionine salvage (GO:0071267)2.70374464
176L-methionine biosynthetic process (GO:0071265)2.70374464
177serotonin metabolic process (GO:0042428)2.69816917
178behavioral response to nicotine (GO:0035095)2.65718741
179phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65480235
180bile acid biosynthetic process (GO:0006699)2.60922599
181androgen biosynthetic process (GO:0006702)2.60349524
182nicotinamide nucleotide biosynthetic process (GO:0019359)2.60105354
183pyridine nucleotide biosynthetic process (GO:0019363)2.60105354
184nucleoside diphosphate catabolic process (GO:0009134)2.58701147
185methionine biosynthetic process (GO:0009086)2.58644982
186regulation of interleukin-13 production (GO:0032656)2.57564143
187disruption of cells of other organism (GO:0044364)2.57500956
188killing of cells of other organism (GO:0031640)2.57500956
189regulation of action potential (GO:0098900)2.57285403
190cardiolipin metabolic process (GO:0032048)2.53121680
191G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52913697
192cellular response to sterol (GO:0036315)2.52050970
193epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52049577
194protein prenylation (GO:0018342)2.49897695
195prenylation (GO:0097354)2.49897695
196primary amino compound metabolic process (GO:1901160)2.48858726
197neurofilament cytoskeleton organization (GO:0060052)12.2159748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF15_26573619_Chip-Seq_HEK293_Human3.83916693
2IGF1R_20145208_ChIP-Seq_DFB_Human3.70429340
3GBX2_23144817_ChIP-Seq_PC3_Human3.24582412
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.12832292
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.96980965
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78898613
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77017553
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74404594
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70401290
10AR_21572438_ChIP-Seq_LNCaP_Human2.51450136
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46216697
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40787089
13NR3C1_23031785_ChIP-Seq_PC12_Mouse2.35869961
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31963659
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31808358
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31808358
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26209077
18EZH2_22144423_ChIP-Seq_EOC_Human2.26011195
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22501239
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.16954552
21REST_21632747_ChIP-Seq_MESCs_Mouse2.15782417
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12780261
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11270192
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10537227
25ER_23166858_ChIP-Seq_MCF-7_Human2.09012047
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04680317
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.03768423
28SMAD4_21799915_ChIP-Seq_A2780_Human1.99459032
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.97674891
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89103656
31EWS_26573619_Chip-Seq_HEK293_Human1.87551247
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.86908239
33FUS_26573619_Chip-Seq_HEK293_Human1.84961870
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.82757401
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.81960574
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77768912
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75334997
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71863241
39RNF2_27304074_Chip-Seq_NSC_Mouse1.68232214
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67941293
41TCF4_23295773_ChIP-Seq_U87_Human1.64745234
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64269683
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63793818
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63399788
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63350144
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62599465
47P300_19829295_ChIP-Seq_ESCs_Human1.60909051
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60372716
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58306818
50AR_25329375_ChIP-Seq_VCAP_Human1.57886924
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57824535
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.57635002
53STAT3_23295773_ChIP-Seq_U87_Human1.57368180
54BCAT_22108803_ChIP-Seq_LS180_Human1.56861085
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54793221
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.53891330
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50140275
58CBP_20019798_ChIP-Seq_JUKART_Human1.45897373
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45897373
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45764686
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45319929
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44401791
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.43688044
64ZNF274_21170338_ChIP-Seq_K562_Hela1.43433104
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40004650
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.39711918
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38803288
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38799889
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.37861270
70TCF4_22108803_ChIP-Seq_LS180_Human1.37220972
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.36630612
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35648619
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34528474
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.33816392
75AHR_22903824_ChIP-Seq_MCF-7_Human1.33718458
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.33658900
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.33655956
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32877134
79CDX2_22108803_ChIP-Seq_LS180_Human1.32094101
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.31789895
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31224874
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30717766
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.30140980
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.29697665
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28922676
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28922676
87JUN_21703547_ChIP-Seq_K562_Human1.27222333
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27192922
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27096480
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.26477882
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23790598
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23467576
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23463104
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21961917
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.21627838
96TP53_16413492_ChIP-PET_HCT116_Human1.21378216
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20734074
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20313175
99IRF1_19129219_ChIP-ChIP_H3396_Human1.19574565
100KDM2B_26808549_Chip-Seq_REH_Human1.19571231
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18727804
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18308971
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17997588
104P53_22387025_ChIP-Seq_ESCs_Mouse1.17563804
105NANOG_19829295_ChIP-Seq_ESCs_Human1.17090597
106SOX2_19829295_ChIP-Seq_ESCs_Human1.17090597
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16266605
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16240642
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.14749213
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.14524991
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.13312527
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12699652
113TP53_22573176_ChIP-Seq_HFKS_Human1.12648638
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12505513
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12466839
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11455186
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11161214
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11014860
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10613029
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.09444988
121DROSHA_22980978_ChIP-Seq_HELA_Human1.09352068
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08718176
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08599810
124SMAD3_21741376_ChIP-Seq_ESCs_Human1.07794350
125OCT1_27270436_Chip-Seq_PROSTATE_Human1.07737229
126FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07664505
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.07664505
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07578911
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07065466
130POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05799169
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05509293
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05197827
133ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04907925
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.04489980
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.03975012
136P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03305395
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.02908287
138CJUN_26792858_Chip-Seq_BT549_Human1.01983373
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01953292
140KDM2B_26808549_Chip-Seq_K562_Human1.01875163
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01341390
142NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01341390
143AR_19668381_ChIP-Seq_PC3_Human1.00826426
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.98476414
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97557170
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.96211430
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95769055
148VDR_22108803_ChIP-Seq_LS180_Human0.95686437
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94179339
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92675935
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92585055
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.91487458
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90623920
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.88565478
155RUNX2_22187159_ChIP-Seq_PCA_Human0.88276477
156TP63_23658742_ChIP-Seq_EP156T_Human0.88182049
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88014451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception7.71862802
2MP0004270_analgesia5.46337533
3MP0004858_abnormal_nervous_system4.91259776
4MP0004147_increased_porphyrin_level4.78153806
5MP0006276_abnormal_autonomic_nervous4.42278834
6MP0000569_abnormal_digit_pigmentation4.31261570
7MP0002736_abnormal_nociception_after3.80769623
8MP0002734_abnormal_mechanical_nocicepti3.35013803
9MP0001348_abnormal_lacrimal_gland3.30703471
10MP0001968_abnormal_touch/_nociception3.30397659
11MP0001986_abnormal_taste_sensitivity3.22232013
12MP0003195_calcinosis3.12432203
13MP0002733_abnormal_thermal_nociception3.08681453
14MP0005464_abnormal_platelet_physiology2.89760956
15MP0003252_abnormal_bile_duct2.87277738
16MP0001970_abnormal_pain_threshold2.68583769
17MP0009046_muscle_twitch2.68091931
18MP0005551_abnormal_eye_electrophysiolog2.62604870
19MP0001501_abnormal_sleep_pattern2.60434891
20MP0003880_abnormal_central_pattern2.51670281
21MP0004859_abnormal_synaptic_plasticity2.47194529
22MP0003329_amyloid_beta_deposits2.41840436
23MP0005646_abnormal_pituitary_gland2.41580423
24MP0002184_abnormal_innervation2.31821926
25MP0008057_abnormal_DNA_replication2.10463656
26MP0002751_abnormal_autonomic_nervous2.07546401
27MP0008872_abnormal_physiological_respon2.03693572
28MP0002102_abnormal_ear_morphology2.02687357
29MP0002067_abnormal_sensory_capabilities1.97219886
30MP0003950_abnormal_plasma_membrane1.97184578
31MP0002272_abnormal_nervous_system1.95734075
32MP0005174_abnormal_tail_pigmentation1.93816932
33MP0008877_abnormal_DNA_methylation1.91793445
34MP0005253_abnormal_eye_physiology1.88499231
35MP0003011_delayed_dark_adaptation1.87128188
36MP0000955_abnormal_spinal_cord1.81195461
37MP0003635_abnormal_synaptic_transmissio1.79468814
38MP0010386_abnormal_urinary_bladder1.78224147
39MP0003646_muscle_fatigue1.76207736
40MP0009379_abnormal_foot_pigmentation1.73030461
41MP0005410_abnormal_fertilization1.72012469
42MP0000383_abnormal_hair_follicle1.71997970
43MP0004043_abnormal_pH_regulation1.70757133
44MP0000427_abnormal_hair_cycle1.67646863
45MP0000230_abnormal_systemic_arterial1.67261987
46MP0003879_abnormal_hair_cell1.66795174
47MP0003136_yellow_coat_color1.64843079
48MP0006054_spinal_hemorrhage1.58062408
49MP0001849_ear_inflammation1.54778883
50MP0004811_abnormal_neuron_physiology1.54693225
51MP0005167_abnormal_blood-brain_barrier1.52364219
52MP0002138_abnormal_hepatobiliary_system1.49628582
53MP0000372_irregular_coat_pigmentation1.49015736
54MP0001919_abnormal_reproductive_system1.47860111
55MP0005310_abnormal_salivary_gland1.46685400
56MP0008569_lethality_at_weaning1.37660441
57MP0000371_diluted_coat_color1.37227497
58MP0004215_abnormal_myocardial_fiber1.36560583
59MP0002063_abnormal_learning/memory/cond1.36014892
60MP0004130_abnormal_muscle_cell1.35541541
61MP0000604_amyloidosis1.34925730
62MP0002229_neurodegeneration1.31502851
63MP0002876_abnormal_thyroid_physiology1.30455632
64MP0002064_seizures1.25753559
65MP0001529_abnormal_vocalization1.24765321
66MP0009745_abnormal_behavioral_response1.24532594
67MP0001299_abnormal_eye_distance/1.22156744
68MP0003183_abnormal_peptide_metabolism1.20246411
69MP0001486_abnormal_startle_reflex1.19827651
70MP0005645_abnormal_hypothalamus_physiol1.18762678
71MP0008004_abnormal_stomach_pH1.17995296
72MP0002882_abnormal_neuron_morphology1.17584067
73MP0004145_abnormal_muscle_electrophysio1.17102715
74MP0003045_fibrosis1.16677838
75MP0005670_abnormal_white_adipose1.16608110
76MP0001485_abnormal_pinna_reflex1.15653899
77MP0000751_myopathy1.13060487
78MP0004142_abnormal_muscle_tone1.13015227
79MP0002572_abnormal_emotion/affect_behav1.12807126
80MP0002752_abnormal_somatic_nervous1.12354006
81MP0003718_maternal_effect1.11004941
82MP0001963_abnormal_hearing_physiology1.10276142
83MP0006072_abnormal_retinal_apoptosis1.09040871
84MP0003656_abnormal_erythrocyte_physiolo1.08113846
85MP0005084_abnormal_gallbladder_morpholo1.07005013
86MP0004883_abnormal_blood_vessel1.06691585
87MP0002638_abnormal_pupillary_reflex1.03099184
88MP0000778_abnormal_nervous_system1.01870868
89MP0008875_abnormal_xenobiotic_pharmacok1.01028718
90MP0003724_increased_susceptibility_to1.00697716
91MP0005386_behavior/neurological_phenoty0.99745318
92MP0004924_abnormal_behavior0.99745318
93MP0002837_dystrophic_cardiac_calcinosis0.98448717
94MP0000631_abnormal_neuroendocrine_gland0.98266962
95MP0002066_abnormal_motor_capabilities/c0.97835182
96MP0001188_hyperpigmentation0.93231061
97MP0000749_muscle_degeneration0.92996909
98MP0001664_abnormal_digestion0.91413323
99MP0000534_abnormal_ureter_morphology0.89681152
100MP0005389_reproductive_system_phenotype0.87926481
101MP0003638_abnormal_response/metabolism_0.87823563
102MP0000538_abnormal_urinary_bladder0.87590362
103MP0003137_abnormal_impulse_conducting0.86768550
104MP0004036_abnormal_muscle_relaxation0.85723333
105MP0003698_abnormal_male_reproductive0.84072952
106MP0010678_abnormal_skin_adnexa0.83437525
107MP0010329_abnormal_lipoprotein_level0.83248968
108MP0002168_other_aberrant_phenotype0.82988531
109MP0002938_white_spotting0.82955135
110MP0005075_abnormal_melanosome_morpholog0.82746460
111MP0003634_abnormal_glial_cell0.78889159
112MP0002693_abnormal_pancreas_physiology0.78701174
113MP0003787_abnormal_imprinting0.78014091
114MP0002928_abnormal_bile_duct0.77818578
115MP0009764_decreased_sensitivity_to0.77701895
116MP0001440_abnormal_grooming_behavior0.77264076
117MP0004085_abnormal_heartbeat0.76443116
118MP0002234_abnormal_pharynx_morphology0.74413968
119MP0001764_abnormal_homeostasis0.73079733
120MP0002095_abnormal_skin_pigmentation0.72788571
121MP0002139_abnormal_hepatobiliary_system0.72704223
122MP0008961_abnormal_basal_metabolism0.71584878
123MP0002295_abnormal_pulmonary_circulatio0.70390646
124MP0005187_abnormal_penis_morphology0.69653935
125MP0002118_abnormal_lipid_homeostasis0.69286625
126MP0005385_cardiovascular_system_phenoty0.68764709
127MP0001544_abnormal_cardiovascular_syste0.68764709
128MP0002972_abnormal_cardiac_muscle0.68287000
129MP0005171_absent_coat_pigmentation0.68001437
130MP0000026_abnormal_inner_ear0.67955796
131MP0003315_abnormal_perineum_morphology0.67269731
132MP0008260_abnormal_autophagy0.66875740
133MP0005535_abnormal_body_temperature0.66567781
134MP0003631_nervous_system_phenotype0.65912134
135MP0003633_abnormal_nervous_system0.65869747
136MP0008874_decreased_physiological_sensi0.65491905
137MP0000653_abnormal_sex_gland0.65341813
138MP0009840_abnormal_foam_cell0.65153039
139MP0002909_abnormal_adrenal_gland0.61321064
140MP0001270_distended_abdomen0.60305814
141MP0005083_abnormal_biliary_tract0.60174658
142MP0002557_abnormal_social/conspecific_i0.58969506
143MP0000015_abnormal_ear_pigmentation0.58385700
144MP0001905_abnormal_dopamine_level0.58343756
145MP0002160_abnormal_reproductive_system0.56802813
146MP0009697_abnormal_copulation0.56268129
147MP0005395_other_phenotype0.55574090
148MP0001984_abnormal_olfaction0.54861745
149MP0003632_abnormal_nervous_system0.54010323
150MP0008775_abnormal_heart_ventricle0.52883241
151MP0000920_abnormal_myelination0.51243808
152MP0005408_hypopigmentation0.51018907
153MP0009780_abnormal_chondrocyte_physiolo0.49249934
154MP0000747_muscle_weakness0.48823022
155MP0000639_abnormal_adrenal_gland0.47848066
156MP0005647_abnormal_sex_gland0.47709862
157MP0005085_abnormal_gallbladder_physiolo0.45279140
158MP0008932_abnormal_embryonic_tissue0.45024697
159MP0004084_abnormal_cardiac_muscle0.45009823
160MP0003699_abnormal_female_reproductive0.44763345

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.83028593
2Myokymia (HP:0002411)8.69462358
3Action tremor (HP:0002345)6.36839726
4Genetic anticipation (HP:0003743)6.19937183
5Gaze-evoked nystagmus (HP:0000640)4.96807640
6Atonic seizures (HP:0010819)4.73606887
7Segmental peripheral demyelination/remyelination (HP:0003481)4.72949472
8Febrile seizures (HP:0002373)4.62637386
9Hypothermia (HP:0002045)4.59374543
10Foot dorsiflexor weakness (HP:0009027)4.41608697
11Pheochromocytoma (HP:0002666)4.36172938
12Termporal pattern (HP:0011008)4.31425622
13Insidious onset (HP:0003587)4.31425622
14Steppage gait (HP:0003376)4.28412238
15Focal motor seizures (HP:0011153)4.21290829
16Hyperventilation (HP:0002883)4.17374903
17Neuroendocrine neoplasm (HP:0100634)4.11177418
18Hammertoe (HP:0001765)4.03701078
19Dysmetric saccades (HP:0000641)4.01563785
20Fetal akinesia sequence (HP:0001989)3.99421687
21Pancreatic cysts (HP:0001737)3.95031583
22Abnormality of the foot musculature (HP:0001436)3.93664062
23Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.57814191
24Prostate neoplasm (HP:0100787)3.54358055
25Impaired pain sensation (HP:0007328)3.41528791
26Abnormality of pain sensation (HP:0010832)3.41528791
27Supranuclear gaze palsy (HP:0000605)3.37856398
28Prolonged bleeding time (HP:0003010)3.37218163
29Attenuation of retinal blood vessels (HP:0007843)3.35811862
30Decreased motor nerve conduction velocity (HP:0003431)3.35278405
31Pancreatic fibrosis (HP:0100732)3.33829650
32True hermaphroditism (HP:0010459)3.33508006
33Spastic gait (HP:0002064)3.27204121
34Congenital stationary night blindness (HP:0007642)3.23645447
35Ventricular fibrillation (HP:0001663)3.22884019
36Areflexia of lower limbs (HP:0002522)3.19738131
37Distal sensory impairment (HP:0002936)3.17479455
38Congenital sensorineural hearing impairment (HP:0008527)3.16759041
39Decreased central vision (HP:0007663)3.13095441
40Abnormality of the renal cortex (HP:0011035)3.11527534
41Clumsiness (HP:0002312)3.08660879
42Autoamputation (HP:0001218)2.99506367
43Failure to thrive in infancy (HP:0001531)2.98361309
44Delusions (HP:0000746)2.94609781
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.94089194
46Focal seizures (HP:0007359)2.93579886
47Progressive cerebellar ataxia (HP:0002073)2.92577235
48Fair hair (HP:0002286)2.92035991
49Onion bulb formation (HP:0003383)2.91283163
50Central scotoma (HP:0000603)2.87067158
51Abolished electroretinogram (ERG) (HP:0000550)2.86690912
52Akinesia (HP:0002304)2.86240980
53Abnormality of the hepatic vasculature (HP:0006707)2.85293793
54Absent speech (HP:0001344)2.84709591
55Menorrhagia (HP:0000132)2.84658053
56Protruding tongue (HP:0010808)2.83315268
57Ankle clonus (HP:0011448)2.81616425
58Thyroid carcinoma (HP:0002890)2.80285459
59Distal lower limb muscle weakness (HP:0009053)2.80133979
60Abnormality of midbrain morphology (HP:0002418)2.77268631
61Molar tooth sign on MRI (HP:0002419)2.77268631
62Absence seizures (HP:0002121)2.75407738
63Abnormality of macular pigmentation (HP:0008002)2.74620011
64Bradycardia (HP:0001662)2.74424739
65Pendular nystagmus (HP:0012043)2.74318011
66Hyporeflexia of lower limbs (HP:0002600)2.72784331
67Abnormality of the corticospinal tract (HP:0002492)2.71432315
68Urinary urgency (HP:0000012)2.70193828
69Myotonia (HP:0002486)2.69594519
70Neoplasm of the peripheral nervous system (HP:0100007)2.66834418
71Hypercortisolism (HP:0001578)2.66436492
72Apathy (HP:0000741)2.66304963
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59836846
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.59836846
75Increased corneal curvature (HP:0100692)2.59476256
76Keratoconus (HP:0000563)2.59476256
77Increased mean platelet volume (HP:0011877)2.57257460
78Dysautonomia (HP:0002459)2.56689412
79Bony spicule pigmentary retinopathy (HP:0007737)2.56508168
80Nephronophthisis (HP:0000090)2.53490030
81Severe visual impairment (HP:0001141)2.53356529
82Gingival bleeding (HP:0000225)2.52280383
83Irregular epiphyses (HP:0010582)2.48644201
84Generalized tonic-clonic seizures (HP:0002069)2.41612510
85Abnormality of the prostate (HP:0008775)2.40833939
86Diminished motivation (HP:0000745)2.40776670
87Renal cortical cysts (HP:0000803)2.40457275
88Delayed gross motor development (HP:0002194)2.39766699
89Epistaxis (HP:0000421)2.39018147
90Cystic liver disease (HP:0006706)2.38439352
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37407892
92Abnormality of the renal medulla (HP:0100957)2.37137440
93Abnormal ciliary motility (HP:0012262)2.36939924
94Hyperlipoproteinemia (HP:0010980)2.36738936
95Chronic hepatic failure (HP:0100626)2.35635639
96Urinary bladder sphincter dysfunction (HP:0002839)2.34075081
97Menstrual irregularities (HP:0000858)2.33984737
98Medial flaring of the eyebrow (HP:0010747)2.33936325
99Distal arthrogryposis (HP:0005684)2.33758197
100Abnormal platelet volume (HP:0011876)2.33309189
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32467990
102Absent/shortened dynein arms (HP:0200106)2.31364266
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.31364266
104Abnormality of alanine metabolism (HP:0010916)2.30503305
105Hyperalaninemia (HP:0003348)2.30503305
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30503305
107Scanning speech (HP:0002168)2.29716523
108Fasciculations (HP:0002380)2.28084346
109Inability to walk (HP:0002540)2.28032809
110Dialeptic seizures (HP:0011146)2.27893540
111Petechiae (HP:0000967)2.26353122
112Postural instability (HP:0002172)2.25559217
113Aplasia/Hypoplasia of the tibia (HP:0005772)2.25043892
114Submucous cleft hard palate (HP:0000176)2.22302703
115Generalized hypopigmentation of hair (HP:0011358)2.20464244
116Increased neuronal autofluorescent lipopigment (HP:0002074)2.18971498
117Facial diplegia (HP:0001349)2.17614915
118Impaired vibratory sensation (HP:0002495)2.15144125
119Dyschromatopsia (HP:0007641)2.14518362
120Cerebral hemorrhage (HP:0001342)2.13018979
121Poor suck (HP:0002033)2.12550373
122Impaired vibration sensation in the lower limbs (HP:0002166)2.11470280
123Tubular atrophy (HP:0000092)2.09100729
124Anosmia (HP:0000458)2.09087540
125Thoracolumbar scoliosis (HP:0002944)2.07768471
126Polydipsia (HP:0001959)2.06757576
127Abnormal drinking behavior (HP:0030082)2.06757576
128Hemiparesis (HP:0001269)2.06269637
129EMG: neuropathic changes (HP:0003445)2.05447282
130Hypochromic microcytic anemia (HP:0004840)2.05354099
131Increased density of long bones (HP:0006392)2.05091885
132Truncal ataxia (HP:0002078)2.05074129
133Paraplegia (HP:0010550)2.02594126
134Retinitis pigmentosa (HP:0000510)2.01556209
135Tinnitus (HP:0000360)1.99910194
136Lower limb muscle weakness (HP:0007340)1.99443724
137Biliary tract neoplasm (HP:0100574)1.99297635
138Decreased muscle mass (HP:0003199)1.97913585
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.96596088
140Hypoplasia of the fovea (HP:0007750)1.95756549
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.95756549
142Congenital hepatic fibrosis (HP:0002612)1.95410481
143Abnormal respiratory motile cilium physiology (HP:0012261)1.95172703
144Proximal tubulopathy (HP:0000114)1.92652696
145Muscle fibrillation (HP:0010546)1.92258581
146Chorioretinal atrophy (HP:0000533)1.92115473
147Abnormality of the musculature of the hand (HP:0001421)1.91765288
148Chin dimple (HP:0010751)1.91612636
149Epileptic encephalopathy (HP:0200134)1.90690897
150Pes cavus (HP:0001761)1.90224053
151Impaired smooth pursuit (HP:0007772)1.90012559
152Abnormal hair whorl (HP:0010721)1.89727746
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89314125
154Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88895795
155Hypoplasia of the brainstem (HP:0002365)1.88895795
156Sclerocornea (HP:0000647)1.87606351
157Widely spaced teeth (HP:0000687)1.87560549
158Dysdiadochokinesis (HP:0002075)1.86681162
159Amblyopia (HP:0000646)1.86227041
160Scotoma (HP:0000575)1.86097914
161Hypoproteinemia (HP:0003075)1.85942524
162Furrowed tongue (HP:0000221)1.84333884
163Ileus (HP:0002595)1.82884458
164Stridor (HP:0010307)1.82394568
165Progressive inability to walk (HP:0002505)1.82320437
166Tongue fasciculations (HP:0001308)1.81957014
167Growth hormone excess (HP:0000845)1.80622925
168Male pseudohermaphroditism (HP:0000037)1.80566713
169Abnormal eating behavior (HP:0100738)1.79851413
170Portal hypertension (HP:0001409)1.79810539
171Broad-based gait (HP:0002136)1.79702487
172Thyroid-stimulating hormone excess (HP:0002925)1.79531045
173Abnormality of the vocal cords (HP:0008777)1.78718204
174Abnormal rod and cone electroretinograms (HP:0008323)1.78364615
175Hypoventilation (HP:0002791)1.77287921
176Slow saccadic eye movements (HP:0000514)1.76944765
177Constricted visual fields (HP:0001133)1.74628958
178Lower limb asymmetry (HP:0100559)1.73283769
179Muscle stiffness (HP:0003552)1.72764148
180Wrist flexion contracture (HP:0001239)1.71749093
181Prolonged QT interval (HP:0001657)1.70502221
182Visual hallucinations (HP:0002367)1.70022273
183Generalized hypotonia (HP:0001290)1.69208731
184Knee flexion contracture (HP:0006380)1.68350977
185Spastic paraplegia (HP:0001258)1.68082407
186Curly hair (HP:0002212)1.64842735
187Potter facies (HP:0002009)1.64758531
188Facial shape deformation (HP:0011334)1.64758531
189Palpitations (HP:0001962)1.63360467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.53241432
2NTRK35.51023467
3MAPKAPK34.18414848
4LMTK24.16461983
5MINK14.13037297
6ACVR1B3.45311611
7CASK3.38444863
8LATS23.18118982
9BMPR1B2.86001112
10ADRBK22.61858332
11OXSR12.54166528
12NEK92.53461902
13KSR22.50384493
14MAP3K92.48825898
15NTRK12.44476012
16MAP3K122.38348840
17SCYL22.37776072
18MAPK132.36941245
19MAP3K42.19163270
20MAP2K42.06174009
21GRK12.02976778
22GRK71.92960467
23NUAK11.92160240
24TAOK31.92009151
25MAP2K71.89591740
26WNK31.87102126
27LIMK11.84451393
28WNK11.79391126
29MUSK1.72164243
30INSRR1.70443151
31MAP4K21.69781052
32ARAF1.68028165
33PIK3CG1.66881193
34PHKG11.64473646
35PHKG21.64473646
36ZAK1.64005440
37PTK2B1.58036267
38MST41.56642788
39TEC1.55542333
40MKNK21.53392264
41SIK31.50260402
42STK38L1.49502564
43SGK21.48376906
44STK31.41812387
45RET1.41651658
46TXK1.31033650
47SGK4941.26736133
48SGK2231.26736133
49PAK61.26707795
50EPHA31.26646104
51MAP2K11.26510075
52MATK1.25783641
53TRIM281.25145452
54TNIK1.20237040
55ERBB41.12611491
56BRAF1.09047047
57STK391.08728290
58RPS6KB21.08609369
59DAPK21.06542253
60ADRBK11.01859451
61FER1.01704540
62MAP3K110.99079834
63MAP3K20.98191015
64KSR10.97439492
65BRSK20.94736043
66SGK30.94313395
67RPS6KA20.92894855
68MKNK10.89868492
69WNK40.89790214
70MAP3K70.87860521
71STK240.87487625
72MYLK0.86355760
73TGFBR10.85080616
74BTK0.77900321
75NEK10.76606754
76DYRK20.75091695
77IRAK10.74910536
78PRKCG0.73668144
79TNK20.73063594
80CAMKK10.72519310
81AURKA0.71836981
82CAMKK20.71510116
83AKT30.71313567
84BMX0.69326788
85GRK50.68818336
86PRKCH0.67751033
87MOS0.63557747
88CDK50.62769551
89BCR0.62084150
90MAP3K60.59365237
91ERBB30.59061594
92RAF10.58030656
93BLK0.56369388
94MAP3K10.56190468
95PKN10.55940881
96TIE10.55856614
97SYK0.55559238
98CAMK2G0.55202823
99PDPK10.54231078
100IKBKB0.53969597
101PLK20.51448588
102ERBB20.50228026
103PRKACB0.49406795
104PRKAA20.48413604
105ROCK20.48099657
106CSNK1E0.47947378
107CSF1R0.47125961
108PIK3CA0.46659798
109MAPKAPK50.46500460
110MARK30.45167055
111PDK10.45101348
112CSNK1G10.44076653
113ITK0.42066318
114PINK10.41226544
115TRPM70.40880258
116PRKG10.40795953
117CAMK2A0.40615777
118RIPK40.40557290
119STK380.40294748
120NLK0.39761528
121BMPR20.38994012
122PRKD30.38083517
123EPHA40.36728088
124CSNK1G20.36571677
125PRKG20.35479851
126CSNK1A1L0.35258102
127ROCK10.34931774
128MARK10.34795132
129CSNK1D0.34171174
130EIF2AK10.34041558
131YES10.33686276
132LYN0.33473675
133MAPK100.32680564
134PLK40.30998836
135MELK0.30183360
136CSNK1A10.29944850
137OBSCN0.29133763
138CCNB10.28975686
139PNCK0.28588308
140PRKCA0.28507115
141RPS6KB10.28370159
142IGF1R0.27668066
143CDK140.27578173
144PRKCB0.27510354
145MAP2K60.27396517
146TAOK10.27216407
147PRKACG0.27058185
148HCK0.26758134
149CAMK10.26371183
150PRKCQ0.26149973
151PDK30.25925143
152PDK40.25925143
153PLK30.25907438
154MAP3K130.25406657
155LATS10.25092054
156PAK30.25068333
157FLT30.24314278
158ABL10.24282670
159ABL20.23990466
160PRKACA0.23830135
161RPS6KA30.21876281
162BRSK10.21848211
163CDK180.20185843
164CDK190.19847338
165CSNK1G30.18817405
166FGFR30.18588887
167PRKCE0.17732020
168MAPK80.17535256

Predicted pathways (KEGG)

RankGene SetZ-score
1Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.96703590
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.80009877
3Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050143.50897333
4Synaptic vesicle cycle_Homo sapiens_hsa047213.17802522
5Olfactory transduction_Homo sapiens_hsa047402.85769274
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.83524917
7Butanoate metabolism_Homo sapiens_hsa006502.51121974
8Nitrogen metabolism_Homo sapiens_hsa009102.39846535
9Linoleic acid metabolism_Homo sapiens_hsa005912.34826683
10Phototransduction_Homo sapiens_hsa047442.31951052
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29987324
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.21195975
13Tryptophan metabolism_Homo sapiens_hsa003802.13609634
14Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.99491241
15Oocyte meiosis_Homo sapiens_hsa041141.97900149
16ABC transporters_Homo sapiens_hsa020101.96384520
17Dopaminergic synapse_Homo sapiens_hsa047281.90677900
18Dorso-ventral axis formation_Homo sapiens_hsa043201.89944153
19Platelet activation_Homo sapiens_hsa046111.89199283
20Long-term potentiation_Homo sapiens_hsa047201.82738796
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80411215
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.78665124
23GnRH signaling pathway_Homo sapiens_hsa049121.77573392
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70467391
25Cholinergic synapse_Homo sapiens_hsa047251.69610145
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69344592
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58520485
28Morphine addiction_Homo sapiens_hsa050321.58267280
29Homologous recombination_Homo sapiens_hsa034401.55721476
30ErbB signaling pathway_Homo sapiens_hsa040121.55708540
31Taste transduction_Homo sapiens_hsa047421.54359381
32Thyroid cancer_Homo sapiens_hsa052161.50622290
33Arachidonic acid metabolism_Homo sapiens_hsa005901.50322449
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50260408
35Retinol metabolism_Homo sapiens_hsa008301.50047435
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43779854
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41453136
38Pyruvate metabolism_Homo sapiens_hsa006201.40593203
39Glycerolipid metabolism_Homo sapiens_hsa005611.37880507
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37317902
41Propanoate metabolism_Homo sapiens_hsa006401.34315818
42Gastric acid secretion_Homo sapiens_hsa049711.31430826
43Chemical carcinogenesis_Homo sapiens_hsa052041.29051452
44Circadian entrainment_Homo sapiens_hsa047131.28963027
45Caffeine metabolism_Homo sapiens_hsa002321.28223727
46Insulin secretion_Homo sapiens_hsa049111.27652509
47Glioma_Homo sapiens_hsa052141.26252986
48Melanoma_Homo sapiens_hsa052181.25486161
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24604934
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24403795
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.20414715
52Amphetamine addiction_Homo sapiens_hsa050311.17680782
53VEGF signaling pathway_Homo sapiens_hsa043701.17004672
54Oxidative phosphorylation_Homo sapiens_hsa001901.14538677
55Fatty acid biosynthesis_Homo sapiens_hsa000611.12106163
56Insulin signaling pathway_Homo sapiens_hsa049101.10532863
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09906397
58beta-Alanine metabolism_Homo sapiens_hsa004101.08725804
59Serotonergic synapse_Homo sapiens_hsa047261.08608159
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08338926
61Prolactin signaling pathway_Homo sapiens_hsa049171.07994960
62Fanconi anemia pathway_Homo sapiens_hsa034601.07752827
63Gap junction_Homo sapiens_hsa045401.07333189
64Endometrial cancer_Homo sapiens_hsa052131.06496684
65Alzheimers disease_Homo sapiens_hsa050101.06108313
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05930967
67Parkinsons disease_Homo sapiens_hsa050121.05592137
68Salmonella infection_Homo sapiens_hsa051321.05127165
69Glucagon signaling pathway_Homo sapiens_hsa049221.03901156
70Cyanoamino acid metabolism_Homo sapiens_hsa004601.02808479
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01858925
72Glutamatergic synapse_Homo sapiens_hsa047241.01689190
73Collecting duct acid secretion_Homo sapiens_hsa049661.00665231
74Oxytocin signaling pathway_Homo sapiens_hsa049211.00396433
75Sphingolipid metabolism_Homo sapiens_hsa006000.94534636
76Calcium signaling pathway_Homo sapiens_hsa040200.94268746
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92654335
78Regulation of autophagy_Homo sapiens_hsa041400.92440600
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92405338
80Salivary secretion_Homo sapiens_hsa049700.90691978
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89842213
82Vibrio cholerae infection_Homo sapiens_hsa051100.89749856
83Histidine metabolism_Homo sapiens_hsa003400.89333713
84Selenocompound metabolism_Homo sapiens_hsa004500.88838204
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88609773
86Melanogenesis_Homo sapiens_hsa049160.87630115
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86447883
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86193148
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85419771
90Phagosome_Homo sapiens_hsa041450.84756448
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82913039
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.82729633
93Ras signaling pathway_Homo sapiens_hsa040140.82228838
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81853747
95Huntingtons disease_Homo sapiens_hsa050160.81307244
96Cardiac muscle contraction_Homo sapiens_hsa042600.81255973
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.80563593
98Renin secretion_Homo sapiens_hsa049240.80085744
99Axon guidance_Homo sapiens_hsa043600.79627731
100cAMP signaling pathway_Homo sapiens_hsa040240.78749706
101Ovarian steroidogenesis_Homo sapiens_hsa049130.78564062
102Fatty acid elongation_Homo sapiens_hsa000620.77425915
103Nicotine addiction_Homo sapiens_hsa050330.76748325
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76291057
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76247862
106Estrogen signaling pathway_Homo sapiens_hsa049150.74798965
107Steroid biosynthesis_Homo sapiens_hsa001000.74294691
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73226785
109Endocytosis_Homo sapiens_hsa041440.70181100
110MAPK signaling pathway_Homo sapiens_hsa040100.70048525
111Prion diseases_Homo sapiens_hsa050200.69754959
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.68779645
113Fatty acid degradation_Homo sapiens_hsa000710.66474778
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.66028516
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65975510
116Pancreatic secretion_Homo sapiens_hsa049720.65533206
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64527309
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.63932177
119Long-term depression_Homo sapiens_hsa047300.62726508
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.62566827
121Peroxisome_Homo sapiens_hsa041460.60352822
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59712196
123Rap1 signaling pathway_Homo sapiens_hsa040150.59382281
124Inositol phosphate metabolism_Homo sapiens_hsa005620.58937589
125Colorectal cancer_Homo sapiens_hsa052100.58837929
126Purine metabolism_Homo sapiens_hsa002300.56915675
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54591198
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54130814
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53805393
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53582969
131Circadian rhythm_Homo sapiens_hsa047100.51862589
132GABAergic synapse_Homo sapiens_hsa047270.51481029
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50785053
134Non-homologous end-joining_Homo sapiens_hsa034500.50056080
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49613500
136Glutathione metabolism_Homo sapiens_hsa004800.49501592
137Basal transcription factors_Homo sapiens_hsa030220.48404900
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47732392
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.47376996
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46699820
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46079156
142Starch and sucrose metabolism_Homo sapiens_hsa005000.45972772
143PPAR signaling pathway_Homo sapiens_hsa033200.44753197
144Pancreatic cancer_Homo sapiens_hsa052120.44524348
145Hematopoietic cell lineage_Homo sapiens_hsa046400.43766200
146Fat digestion and absorption_Homo sapiens_hsa049750.43211147
147Fatty acid metabolism_Homo sapiens_hsa012120.42560333
148Renin-angiotensin system_Homo sapiens_hsa046140.41252083
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41025556
150Bile secretion_Homo sapiens_hsa049760.40726038
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39885983
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.39114000
153RNA polymerase_Homo sapiens_hsa030200.38590052
154Choline metabolism in cancer_Homo sapiens_hsa052310.37538558
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37484888
156mTOR signaling pathway_Homo sapiens_hsa041500.37061569
157Ether lipid metabolism_Homo sapiens_hsa005650.37024847
158Type II diabetes mellitus_Homo sapiens_hsa049300.36841949
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.36709640
160Proteasome_Homo sapiens_hsa030500.35494469
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35135274
162Shigellosis_Homo sapiens_hsa051310.35059619
163Asthma_Homo sapiens_hsa053100.32095378
164ECM-receptor interaction_Homo sapiens_hsa045120.27209374
165Graft-versus-host disease_Homo sapiens_hsa053320.26902701
166Metabolic pathways_Homo sapiens_hsa011000.26641330

Most similar genes based on co-expression Upload to Enrichr

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