TRAPPC2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.88266498
2ATP synthesis coupled proton transport (GO:0015986)7.42239470
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.42239470
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.24143110
5respiratory electron transport chain (GO:0022904)6.16152227
6electron transport chain (GO:0022900)6.01891937
7ribosomal small subunit assembly (GO:0000028)5.80756113
8viral transcription (GO:0019083)5.72171830
9translational termination (GO:0006415)5.52399770
10chaperone-mediated protein transport (GO:0072321)5.43238376
11protein neddylation (GO:0045116)5.12228759
12protein complex biogenesis (GO:0070271)4.90985618
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.81229197
14NADH dehydrogenase complex assembly (GO:0010257)4.81229197
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.81229197
16translational elongation (GO:0006414)4.80103874
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.62285021
18ribosomal large subunit biogenesis (GO:0042273)4.44687280
19maturation of SSU-rRNA (GO:0030490)4.34002380
20viral life cycle (GO:0019058)4.33965123
21translational initiation (GO:0006413)4.29824439
22mitochondrial respiratory chain complex assembly (GO:0033108)4.27354497
23cellular protein complex disassembly (GO:0043624)4.23479550
24translation (GO:0006412)4.22785379
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.19884158
26rRNA modification (GO:0000154)4.18637929
27hydrogen ion transmembrane transport (GO:1902600)4.18624705
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.16323395
29negative regulation of ligase activity (GO:0051352)4.14164948
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.14164948
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.11002696
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.02436570
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.02436570
34GTP biosynthetic process (GO:0006183)3.96501684
35energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.93702557
36ATP hydrolysis coupled proton transport (GO:0015991)3.93702557
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89251633
38axon ensheathment in central nervous system (GO:0032291)3.84863837
39central nervous system myelination (GO:0022010)3.84863837
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.82544187
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.82544187
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.82544187
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.81777568
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.81777568
45proton transport (GO:0015992)3.77052661
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.71455944
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.71455944
48establishment of integrated proviral latency (GO:0075713)3.67766082
49hydrogen transport (GO:0006818)3.67392998
50neuron cell-cell adhesion (GO:0007158)3.67013251
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.66639011
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.65852515
53respiratory chain complex IV assembly (GO:0008535)3.65657888
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63299166
55cellular component biogenesis (GO:0044085)3.62810850
56ATP biosynthetic process (GO:0006754)3.58106819
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.57784366
58pseudouridine synthesis (GO:0001522)3.56893470
59protein complex disassembly (GO:0043241)3.55582196
60protein targeting to membrane (GO:0006612)3.53430151
61proteasome assembly (GO:0043248)3.50791979
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50544265
63oxidative phosphorylation (GO:0006119)3.49892824
64cytochrome complex assembly (GO:0017004)3.48040229
65positive regulation of ligase activity (GO:0051351)3.47835447
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44041845
67macromolecular complex disassembly (GO:0032984)3.43162543
68rRNA methylation (GO:0031167)3.43135120
69phagosome maturation (GO:0090382)3.40219881
70inner mitochondrial membrane organization (GO:0007007)3.39409663
71ribonucleoprotein complex biogenesis (GO:0022613)3.38671469
72CENP-A containing nucleosome assembly (GO:0034080)3.35843053
73spliceosomal snRNP assembly (GO:0000387)3.33849677
74transferrin transport (GO:0033572)3.33232369
75chromatin remodeling at centromere (GO:0031055)3.32982667
76long-chain fatty acid biosynthetic process (GO:0042759)3.29880296
77dopamine transport (GO:0015872)3.28808015
78water-soluble vitamin biosynthetic process (GO:0042364)3.27374888
79regulation of ubiquitin-protein transferase activity (GO:0051438)3.25503558
80nuclear-transcribed mRNA catabolic process (GO:0000956)3.22597885
81platelet dense granule organization (GO:0060155)3.17995327
82rRNA processing (GO:0006364)3.15929489
83ribonucleoside triphosphate biosynthetic process (GO:0009201)3.15236396
84establishment of viral latency (GO:0019043)3.15151789
85substantia nigra development (GO:0021762)3.14195297
86regulation of ligase activity (GO:0051340)3.14118321
87pteridine-containing compound biosynthetic process (GO:0042559)3.13693022
88DNA replication checkpoint (GO:0000076)3.13663883
89regulation of mitochondrial translation (GO:0070129)3.11568755
90presynaptic membrane assembly (GO:0097105)3.10860951
91UTP biosynthetic process (GO:0006228)3.10011852
92transcription-coupled nucleotide-excision repair (GO:0006283)3.08955581
93protein targeting to mitochondrion (GO:0006626)3.05240449
94trivalent inorganic cation transport (GO:0072512)3.04203998
95ferric iron transport (GO:0015682)3.04203998
96regulation of glutamate secretion (GO:0014048)3.03723165
97guanosine-containing compound biosynthetic process (GO:1901070)3.03133717
98establishment of protein localization to mitochondrion (GO:0072655)3.02695967
99transcription elongation from RNA polymerase III promoter (GO:0006385)3.01829174
100termination of RNA polymerase III transcription (GO:0006386)3.01829174
101ribosomal small subunit biogenesis (GO:0042274)2.98437765
102regulation of catecholamine metabolic process (GO:0042069)2.98361457
103regulation of dopamine metabolic process (GO:0042053)2.98361457
104dopamine biosynthetic process (GO:0042416)2.93226565
105presynaptic membrane organization (GO:0097090)2.93017002
106signal peptide processing (GO:0006465)2.92572880
107regulation of oxidative phosphorylation (GO:0002082)2.88480792
108cullin deneddylation (GO:0010388)2.87590470
109protein localization to cilium (GO:0061512)2.86351615
110nucleoside diphosphate phosphorylation (GO:0006165)2.83797254
111fatty acid elongation (GO:0030497)2.81874937
112cotranslational protein targeting to membrane (GO:0006613)2.80274719
113regulation of cellular amino acid metabolic process (GO:0006521)2.76979660
114intracellular protein transmembrane import (GO:0044743)2.76666017
115negative regulation of neurotransmitter transport (GO:0051589)2.75683354
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75654849
117nucleoside triphosphate biosynthetic process (GO:0009142)2.75309903
118protein localization to mitochondrion (GO:0070585)2.74168858
119mannosylation (GO:0097502)2.73588012
120protein targeting to ER (GO:0045047)2.70994003
121CTP metabolic process (GO:0046036)2.70211970
122CTP biosynthetic process (GO:0006241)2.70211970
123positive regulation of synapse assembly (GO:0051965)2.68205460
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67172654
125SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66700796
126protein localization to endoplasmic reticulum (GO:0070972)2.64205909
127antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.61264658
128establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60253555
1297-methylguanosine mRNA capping (GO:0006370)2.59239282
130positive regulation of mitochondrial fission (GO:0090141)2.58405404
1317-methylguanosine RNA capping (GO:0009452)2.57892488
132RNA capping (GO:0036260)2.57892488
133startle response (GO:0001964)2.57702871
134protein deneddylation (GO:0000338)2.57515538
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.54456548
136calcium-mediated signaling using intracellular calcium source (GO:0035584)2.52955090
137UTP metabolic process (GO:0046051)2.52711715
138mitochondrial transport (GO:0006839)2.51604587
139negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49660138
140viral protein processing (GO:0019082)2.46167337
141positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.45914599
142regulation of protein kinase A signaling (GO:0010738)2.45801941
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45370242
144GPI anchor biosynthetic process (GO:0006506)2.44816647
145gamma-aminobutyric acid signaling pathway (GO:0007214)2.44356162
146neurotransmitter uptake (GO:0001504)2.44008920
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43745796
148response to redox state (GO:0051775)2.43636407
149positive regulation of protein homodimerization activity (GO:0090073)2.43281761
150regulation of cellular amine metabolic process (GO:0033238)2.40868166
151mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.39178847
152DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38868539
153protein-cofactor linkage (GO:0018065)2.38739572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.09849903
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.91918180
3EZH2_22144423_ChIP-Seq_EOC_Human3.71039818
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.13370281
5GBX2_23144817_ChIP-Seq_PC3_Human3.06293861
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05202956
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02075447
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93550581
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.93398138
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92548121
11E2F7_22180533_ChIP-Seq_HELA_Human2.79676592
12TAF15_26573619_Chip-Seq_HEK293_Human2.75156166
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69973115
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67633294
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.63251661
16VDR_22108803_ChIP-Seq_LS180_Human2.52924369
17DCP1A_22483619_ChIP-Seq_HELA_Human2.50277465
18FOXP3_21729870_ChIP-Seq_TREG_Human2.49623469
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48082261
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45265695
21XRN2_22483619_ChIP-Seq_HELA_Human2.36245390
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35875352
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35408654
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33804243
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.33042601
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31005658
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26383036
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24713595
29TTF2_22483619_ChIP-Seq_HELA_Human2.15720619
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14711641
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13704532
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12614399
33GABP_19822575_ChIP-Seq_HepG2_Human2.10742405
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06867838
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00724095
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92375426
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89816267
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83488464
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82806115
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80047327
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79771250
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76826127
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76569145
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74593135
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74520658
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74189933
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72642023
48IGF1R_20145208_ChIP-Seq_DFB_Human1.70995529
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.68926105
50ER_23166858_ChIP-Seq_MCF-7_Human1.68111427
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.67228918
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66875356
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66110146
54FUS_26573619_Chip-Seq_HEK293_Human1.65177455
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60933059
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60842410
57REST_21632747_ChIP-Seq_MESCs_Mouse1.60011002
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59326195
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58448696
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56534712
61P300_19829295_ChIP-Seq_ESCs_Human1.56523890
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54579559
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54530182
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.52605625
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52487847
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.51935100
67MYC_18940864_ChIP-ChIP_HL60_Human1.51151759
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50895377
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50114580
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49988752
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48575855
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45367230
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45181320
74* SRF_21415370_ChIP-Seq_HL-1_Mouse1.40808719
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39899173
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38759331
77ELK1_19687146_ChIP-ChIP_HELA_Human1.37394136
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36053885
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33555295
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30635986
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29465560
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29041243
83RNF2_27304074_Chip-Seq_NSC_Mouse1.28874223
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28816857
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28068741
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27550809
87KDM5A_27292631_Chip-Seq_BREAST_Human1.25856622
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24896435
89IRF1_19129219_ChIP-ChIP_H3396_Human1.24879913
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23244667
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.23124881
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.22939069
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.22769698
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22581222
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22401480
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20273173
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19873605
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19873605
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19320232
100* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19039280
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17840026
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17545166
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.16057134
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13426093
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.12211900
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.11048683
107CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10497791
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10142968
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10036716
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.08285229
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07145248
112JUN_21703547_ChIP-Seq_K562_Human1.06618149
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.04892032
114NANOG_16153702_ChIP-ChIP_HESCs_Human1.04557529
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03622945
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03440565
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03332476
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02335988
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.02199332
120* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01674467
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01338663
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.00082909
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99889757
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99733925
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99688597
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.99459906
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99458207
128SMAD4_21799915_ChIP-Seq_A2780_Human0.97486404
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97330196
130EWS_26573619_Chip-Seq_HEK293_Human0.96799464
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95189866
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.95035078
133VDR_23849224_ChIP-Seq_CD4+_Human0.94731990
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94579148
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.94378919
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94089340
137PRDM14_20953172_ChIP-Seq_ESCs_Human0.93841158
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93618319
139REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93187394
140P53_22387025_ChIP-Seq_ESCs_Mouse0.92868867
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.92643241
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92066964
143AR_21909140_ChIP-Seq_LNCAP_Human0.92050345
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91894542
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91874482
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91466573
147* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91348480
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.90432492
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89911534
150P300_18555785_Chip-Seq_ESCs_Mouse0.89827049
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.89314932
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89109061
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88242018
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88047466
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86647862
156SOX2_18555785_Chip-Seq_ESCs_Mouse0.86071221
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85766681
158FOXP1_21924763_ChIP-Seq_HESCs_Human0.84543936
159SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82988838
160PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82196818
161* TFEB_21752829_ChIP-Seq_HELA_Human0.81078719
162ELF5_23300383_ChIP-Seq_T47D_Human0.75958981
163SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75665993
164TP53_22573176_ChIP-Seq_HFKS_Human0.74853182
165NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74312396
166* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72404028
167SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72019940
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.68286008
169ZNF263_19887448_ChIP-Seq_K562_Human0.67168233
170* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66426669
171CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66419793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.91270229
2MP0003806_abnormal_nucleotide_metabolis4.15586430
3MP0001529_abnormal_vocalization3.64705441
4MP0008058_abnormal_DNA_repair3.38506062
5MP0003186_abnormal_redox_activity3.34395121
6MP0001905_abnormal_dopamine_level3.09339562
7MP0010030_abnormal_orbit_morphology2.80973021
8MP0004957_abnormal_blastocyst_morpholog2.78952884
9MP0006276_abnormal_autonomic_nervous2.77838945
10MP0009379_abnormal_foot_pigmentation2.66144735
11MP0002736_abnormal_nociception_after2.62637965
12MP0003693_abnormal_embryo_hatching2.62009491
13MP0001968_abnormal_touch/_nociception2.59450647
14MP0009745_abnormal_behavioral_response2.37249419
15MP0003786_premature_aging2.36301628
16MP0002272_abnormal_nervous_system2.34819354
17MP0002064_seizures2.32967728
18MP0003635_abnormal_synaptic_transmissio2.26057123
19MP0004270_analgesia2.25554851
20MP0010386_abnormal_urinary_bladder2.23966405
21MP0001440_abnormal_grooming_behavior2.23916174
22MP0010094_abnormal_chromosome_stability2.23826449
23MP0009046_muscle_twitch2.20520330
24MP0002837_dystrophic_cardiac_calcinosis2.15577811
25MP0002572_abnormal_emotion/affect_behav2.10894018
26MP0002734_abnormal_mechanical_nocicepti2.07831581
27MP0003111_abnormal_nucleus_morphology2.03231402
28MP0004142_abnormal_muscle_tone2.03096776
29MP0005645_abnormal_hypothalamus_physiol2.01450498
30MP0002735_abnormal_chemical_nociception2.01269476
31MP0001501_abnormal_sleep_pattern2.00642283
32MP0008995_early_reproductive_senescence1.96594606
33MP0005409_darkened_coat_color1.96327926
34MP0004859_abnormal_synaptic_plasticity1.90916299
35MP0003718_maternal_effect1.89935543
36MP0003136_yellow_coat_color1.89524209
37MP0002063_abnormal_learning/memory/cond1.89004228
38MP0005423_abnormal_somatic_nervous1.87468759
39MP0003122_maternal_imprinting1.84897739
40MP0001486_abnormal_startle_reflex1.84712834
41MP0003077_abnormal_cell_cycle1.80197926
42MP0005379_endocrine/exocrine_gland_phen1.79892490
43MP0000920_abnormal_myelination1.79577856
44MP0001188_hyperpigmentation1.79202273
45MP0003941_abnormal_skin_development1.78329910
46MP0008932_abnormal_embryonic_tissue1.76483503
47MP0001984_abnormal_olfaction1.75120337
48MP0004742_abnormal_vestibular_system1.72732161
49MP0001970_abnormal_pain_threshold1.71988960
50MP0002638_abnormal_pupillary_reflex1.68707649
51MP0008007_abnormal_cellular_replicative1.68404031
52MP0002067_abnormal_sensory_capabilities1.63904557
53MP0003011_delayed_dark_adaptation1.63834184
54MP0002876_abnormal_thyroid_physiology1.58371834
55MP0002733_abnormal_thermal_nociception1.58328307
56MP0005171_absent_coat_pigmentation1.54609958
57MP0001986_abnormal_taste_sensitivity1.51815620
58MP0004924_abnormal_behavior1.50246495
59MP0005386_behavior/neurological_phenoty1.50246495
60MP0002163_abnormal_gland_morphology1.45168505
61MP0001764_abnormal_homeostasis1.43250506
62MP0008877_abnormal_DNA_methylation1.42585340
63MP0000778_abnormal_nervous_system1.41787393
64MP0004133_heterotaxia1.40672608
65MP0000372_irregular_coat_pigmentation1.38792719
66MP0002184_abnormal_innervation1.38593304
67MP0005408_hypopigmentation1.32438004
68MP0003123_paternal_imprinting1.30886856
69MP0003329_amyloid_beta_deposits1.29552645
70MP0006072_abnormal_retinal_apoptosis1.27148634
71MP0002557_abnormal_social/conspecific_i1.26897608
72MP0004145_abnormal_muscle_electrophysio1.24106628
73MP0005646_abnormal_pituitary_gland1.22012851
74MP0000358_abnormal_cell_content/1.21713396
75MP0001293_anophthalmia1.21115033
76MP0001346_abnormal_lacrimal_gland1.20611140
77MP0000516_abnormal_urinary_system1.18525067
78MP0005367_renal/urinary_system_phenotyp1.18525067
79MP0005332_abnormal_amino_acid1.17728785
80MP0004019_abnormal_vitamin_homeostasis1.15489128
81MP0002210_abnormal_sex_determination1.15239539
82MP0001502_abnormal_circadian_rhythm1.14533363
83MP0000015_abnormal_ear_pigmentation1.13882311
84MP0002229_neurodegeneration1.12131411
85MP0002254_reproductive_system_inflammat1.11614733
86MP0001727_abnormal_embryo_implantation1.10416322
87MP0005551_abnormal_eye_electrophysiolog1.09904683
88MP0004147_increased_porphyrin_level1.07833437
89MP0002066_abnormal_motor_capabilities/c1.06808170
90MP0003938_abnormal_ear_development1.06752938
91MP0003634_abnormal_glial_cell1.05433089
92MP0008872_abnormal_physiological_respon1.05167437
93MP0005075_abnormal_melanosome_morpholog1.04966893
94MP0006036_abnormal_mitochondrial_physio1.04901204
95MP0002148_abnormal_hypersensitivity_rea1.04319666
96MP0002102_abnormal_ear_morphology1.02775544
97MP0000631_abnormal_neuroendocrine_gland1.01260042
98MP0002882_abnormal_neuron_morphology0.98757877
99MP0002160_abnormal_reproductive_system0.98482337
100MP0001963_abnormal_hearing_physiology0.98000083
101MP0006292_abnormal_olfactory_placode0.97068957
102MP0001485_abnormal_pinna_reflex0.96707580
103MP0002938_white_spotting0.95504079
104MP0000013_abnormal_adipose_tissue0.94688378
105MP0005535_abnormal_body_temperature0.94259985
106MP0000647_abnormal_sebaceous_gland0.93503127
107MP0000653_abnormal_sex_gland0.92989170
108MP0006035_abnormal_mitochondrial_morpho0.92714841
109MP0001145_abnormal_male_reproductive0.92694284
110MP0001929_abnormal_gametogenesis0.91084893
111MP0005410_abnormal_fertilization0.90405666
112MP0002277_abnormal_respiratory_mucosa0.90216159
113MP0001664_abnormal_digestion0.89904266
114MP0000566_synostosis0.89462351
115MP0002095_abnormal_skin_pigmentation0.87637346
116MP0002822_catalepsy0.86337911
117MP0000026_abnormal_inner_ear0.85091329
118MP0000955_abnormal_spinal_cord0.85073762
119MP0005253_abnormal_eye_physiology0.82920254
120MP0002752_abnormal_somatic_nervous0.82860508
121MP0005389_reproductive_system_phenotype0.82178571
122MP0000049_abnormal_middle_ear0.81851390
123MP0006082_CNS_inflammation0.81832198
124MP0000538_abnormal_urinary_bladder0.81617484
125MP0003283_abnormal_digestive_organ0.81297132
126MP0003724_increased_susceptibility_to0.80421371
127MP0005636_abnormal_mineral_homeostasis0.79945943
128MP0008004_abnormal_stomach_pH0.79915240
129MP0002697_abnormal_eye_size0.79823009
130MP0008875_abnormal_xenobiotic_pharmacok0.78934336
131MP0002295_abnormal_pulmonary_circulatio0.78613370
132MP0002751_abnormal_autonomic_nervous0.77849838
133MP0008569_lethality_at_weaning0.76212115
134MP0005084_abnormal_gallbladder_morpholo0.75660413
135MP0003121_genomic_imprinting0.74950970
136MP0003137_abnormal_impulse_conducting0.73799181
137MP0005164_abnormal_response_to0.73758923
138MP0003879_abnormal_hair_cell0.73449486
139MP0004510_myositis0.73060973
140MP0001919_abnormal_reproductive_system0.72693483
141MP0002693_abnormal_pancreas_physiology0.72636083
142MP0004811_abnormal_neuron_physiology0.71847560
143MP0001286_abnormal_eye_development0.71784846
144MP0002233_abnormal_nose_morphology0.71691791
145MP0005377_hearing/vestibular/ear_phenot0.71434488
146MP0003878_abnormal_ear_physiology0.71434488
147MP0001944_abnormal_pancreas_morphology0.71170319
148MP0005310_abnormal_salivary_gland0.70576755
149MP0005499_abnormal_olfactory_system0.70421329
150MP0005394_taste/olfaction_phenotype0.70421329
151MP0004043_abnormal_pH_regulation0.69527757
152MP0001853_heart_inflammation0.68968033
153MP0003690_abnormal_glial_cell0.67599532
154MP0003195_calcinosis0.64515340
155MP0005058_abnormal_lysosome_morphology0.64339723
156MP0008789_abnormal_olfactory_epithelium0.64180757
157MP0003937_abnormal_limbs/digits/tail_de0.63909217
158MP0009780_abnormal_chondrocyte_physiolo0.62799942
159MP0005391_vision/eye_phenotype0.62746147
160MP0003698_abnormal_male_reproductive0.62540168
161MP0002909_abnormal_adrenal_gland0.62097809
162MP0002090_abnormal_vision0.60894866
163MP0009697_abnormal_copulation0.60740860
164MP0000681_abnormal_thyroid_gland0.60135564

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.91673238
2Abnormal mitochondria in muscle tissue (HP:0008316)6.13934712
3Mitochondrial inheritance (HP:0001427)5.93767129
4Progressive macrocephaly (HP:0004481)5.81999208
5Acute encephalopathy (HP:0006846)5.35835696
6Increased hepatocellular lipid droplets (HP:0006565)4.87145798
7Increased CSF lactate (HP:0002490)4.85080451
8Renal Fanconi syndrome (HP:0001994)4.68600463
9Hepatocellular necrosis (HP:0001404)4.67674110
10Reticulocytopenia (HP:0001896)4.23707235
11Lipid accumulation in hepatocytes (HP:0006561)4.22809348
12Hepatic necrosis (HP:0002605)3.83327729
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.78017908
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.70166813
15Optic disc pallor (HP:0000543)3.58667451
16Increased serum pyruvate (HP:0003542)3.56515342
17Abnormality of glycolysis (HP:0004366)3.56515342
18Leukodystrophy (HP:0002415)3.45613609
193-Methylglutaconic aciduria (HP:0003535)3.45555483
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.44455082
21Exercise intolerance (HP:0003546)3.40917195
22Cerebral edema (HP:0002181)3.32882218
23Parakeratosis (HP:0001036)3.31124894
24Focal motor seizures (HP:0011153)3.28895130
25Increased intramyocellular lipid droplets (HP:0012240)3.28250911
26Exertional dyspnea (HP:0002875)3.27858172
27Respiratory failure (HP:0002878)3.27283200
28Medial flaring of the eyebrow (HP:0010747)3.16456967
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.15274679
30Abnormality of renal resorption (HP:0011038)3.02237174
31Methylmalonic acidemia (HP:0002912)2.94488282
32Lactic acidosis (HP:0003128)2.92407220
33Methylmalonic aciduria (HP:0012120)2.84077721
34Gait imbalance (HP:0002141)2.82818573
35Retinal dysplasia (HP:0007973)2.82810853
36Neuroendocrine neoplasm (HP:0100634)2.80375746
37Pheochromocytoma (HP:0002666)2.70534298
38Congenital primary aphakia (HP:0007707)2.69285924
39Lethargy (HP:0001254)2.67502967
40Increased muscle lipid content (HP:0009058)2.61082981
41Nephrogenic diabetes insipidus (HP:0009806)2.61033437
42Increased serum lactate (HP:0002151)2.60420675
43Respiratory difficulties (HP:0002880)2.55043666
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54317782
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54317782
46X-linked dominant inheritance (HP:0001423)2.52646276
47Pallor (HP:0000980)2.49948022
48Congenital, generalized hypertrichosis (HP:0004540)2.49215363
49Hypothermia (HP:0002045)2.48155068
50Congenital ichthyosiform erythroderma (HP:0007431)2.42068440
51Oral leukoplakia (HP:0002745)2.39800091
52Abnormality of cells of the erythroid lineage (HP:0012130)2.36541907
53Abnormal ciliary motility (HP:0012262)2.35758180
54Generalized aminoaciduria (HP:0002909)2.34545518
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.34217137
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34217137
57Abnormality of methionine metabolism (HP:0010901)2.33835176
58Myokymia (HP:0002411)2.30432091
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28005522
60Abnormality of alanine metabolism (HP:0010916)2.28005522
61Hyperalaninemia (HP:0003348)2.28005522
62Vaginal atresia (HP:0000148)2.27106580
63Abnormality of serum amino acid levels (HP:0003112)2.25462879
64Hyperphosphaturia (HP:0003109)2.25424264
65Visual hallucinations (HP:0002367)2.23933392
66Atonic seizures (HP:0010819)2.23863373
67Genital tract atresia (HP:0001827)2.23121574
68Hyperglycinemia (HP:0002154)2.21531627
69Colon cancer (HP:0003003)2.21487828
70Microvesicular hepatic steatosis (HP:0001414)2.21323658
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21318061
72Abnormal protein N-linked glycosylation (HP:0012347)2.21318061
73Abnormal protein glycosylation (HP:0012346)2.21318061
74Abnormal glycosylation (HP:0012345)2.21318061
75Neurofibrillary tangles (HP:0002185)2.21117127
76Abnormality of the labia minora (HP:0012880)2.20585016
77Limb dystonia (HP:0002451)2.19434787
78Abnormal hair whorl (HP:0010721)2.18883690
79Aplastic anemia (HP:0001915)2.16184501
80Abnormal respiratory epithelium morphology (HP:0012253)2.15817497
81Abnormal respiratory motile cilium morphology (HP:0005938)2.15817497
82Abnormal respiratory motile cilium physiology (HP:0012261)2.14530131
83Hyperinsulinemic hypoglycemia (HP:0000825)2.11395631
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11316800
85Hypoglycemic coma (HP:0001325)2.11264875
86Pancytopenia (HP:0001876)2.06105624
87Abnormal pupillary function (HP:0007686)2.05657902
88Dicarboxylic aciduria (HP:0003215)2.04021484
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04021484
90Absence seizures (HP:0002121)2.03364687
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03205528
92Abnormal number of erythroid precursors (HP:0012131)2.01294925
93Delusions (HP:0000746)1.98456581
94Dialeptic seizures (HP:0011146)1.98412806
95Glycosuria (HP:0003076)1.98377548
96Abnormality of urine glucose concentration (HP:0011016)1.98377548
97CNS demyelination (HP:0007305)1.98004739
98Emotional lability (HP:0000712)1.97952018
99Renal tubular dysfunction (HP:0000124)1.95757700
100Megaloblastic anemia (HP:0001889)1.93381822
101Absent/shortened dynein arms (HP:0200106)1.93266358
102Dynein arm defect of respiratory motile cilia (HP:0012255)1.93266358
103Abnormal urine phosphate concentration (HP:0012599)1.90583483
104Cerebral hemorrhage (HP:0001342)1.90572377
105Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88299437
106Type I transferrin isoform profile (HP:0003642)1.87342872
107Testicular atrophy (HP:0000029)1.87086931
108Epileptic encephalopathy (HP:0200134)1.86056242
109Septo-optic dysplasia (HP:0100842)1.85294121
110Absent thumb (HP:0009777)1.85216013
111Aplasia/Hypoplasia of the lens (HP:0008063)1.84108680
112Abnormality of placental membranes (HP:0011409)1.83773381
113Amniotic constriction ring (HP:0009775)1.83773381
114Rhinitis (HP:0012384)1.82221241
115Hyperventilation (HP:0002883)1.81968714
116Sparse eyelashes (HP:0000653)1.81839365
117Polyphagia (HP:0002591)1.80998788
118Reduced antithrombin III activity (HP:0001976)1.76310971
119Esotropia (HP:0000565)1.74481700
120Degeneration of anterior horn cells (HP:0002398)1.74219997
121Abnormality of the anterior horn cell (HP:0006802)1.74219997
122Cerebral inclusion bodies (HP:0100314)1.73212492
123Hypoglycemic seizures (HP:0002173)1.73156822
124Focal seizures (HP:0007359)1.71430921
125Pancreatic fibrosis (HP:0100732)1.69873072
126Meckel diverticulum (HP:0002245)1.69838410
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.69488538
128Anxiety (HP:0000739)1.69133610
129Poor coordination (HP:0002370)1.68815540
130Type II lissencephaly (HP:0007260)1.68367096
131Progressive inability to walk (HP:0002505)1.68218508
132Sclerocornea (HP:0000647)1.68203706
133Ketoacidosis (HP:0001993)1.66173610
134Cerebral hypomyelination (HP:0006808)1.65707144
135Homocystinuria (HP:0002156)1.65371610
136Abnormality of homocysteine metabolism (HP:0010919)1.65371610
137Vomiting (HP:0002013)1.65170714
138Pancreatic cysts (HP:0001737)1.65166970
139Poor suck (HP:0002033)1.63373977
140Multiple enchondromatosis (HP:0005701)1.63170328
141Rough bone trabeculation (HP:0100670)1.63034084
142True hermaphroditism (HP:0010459)1.62437082
143Blindness (HP:0000618)1.62261179
144Short tibia (HP:0005736)1.62143155
145Symptomatic seizures (HP:0011145)1.60620512
146Birth length less than 3rd percentile (HP:0003561)1.58748752
147Abnormality of midbrain morphology (HP:0002418)1.56580141
148Molar tooth sign on MRI (HP:0002419)1.56580141
149Macrocytic anemia (HP:0001972)1.54195314
150Recurrent abscess formation (HP:0002722)1.53742832
151Generalized tonic-clonic seizures (HP:0002069)1.53372588
152Broad-based gait (HP:0002136)1.53182783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.66989703
2MAP3K123.34201410
3ARAF3.07000388
4CASK2.85220217
5ZAK2.52445284
6NME12.39665573
7CDC72.37623537
8MST42.28091125
9STK392.27826574
10RIPK42.27210785
11TNIK2.26652111
12STK162.23802254
13NTRK32.11135899
14PBK2.09226547
15BMPR1B2.02366656
16GRK71.99828324
17TAF11.99587973
18OXSR11.93022644
19PNCK1.91825642
20EPHA41.88870846
21GRK51.88445102
22MAP2K71.86698646
23BMPR21.85879186
24BCKDK1.71528992
25ADRBK21.63596214
26NEK11.63456828
27PLK31.61493331
28MAPKAPK51.61066682
29MAPK151.61052146
30MYLK1.59641133
31MUSK1.58893191
32BCR1.58803962
33EIF2AK11.54564063
34TRIM281.54408372
35NME21.52778478
36MARK11.50841618
37MAPK131.48800532
38PLK21.47478603
39FGR1.45570903
40PLK41.42896894
41PIM21.38371893
42CDK191.37861029
43TTK1.28530602
44WEE11.27401438
45NUAK11.25921801
46BRAF1.21544323
47VRK11.21518361
48WNK41.21440168
49CSNK1G31.20621272
50RPS6KB21.18778887
51UHMK11.17334562
52CAMK2B1.16760383
53DYRK21.14894467
54PASK1.10471897
55TSSK61.10452540
56BRSK21.07435619
57BRSK11.06547270
58PLK11.03379663
59PTK2B1.02883810
60PAK41.02797778
61EIF2AK31.01738895
62DAPK31.00493615
63ILK1.00064273
64CAMK2A0.99610471
65FES0.97595317
66PDK20.95630445
67AURKB0.95129772
68TESK10.92961671
69BUB10.90430572
70MINK10.89089825
71AURKA0.88611160
72WNK30.87725535
73CDK80.84177848
74CAMK2D0.84078128
75LIMK10.83723786
76CHEK20.82219115
77CSNK1A1L0.82074514
78PRKCE0.81084605
79ABL20.79055141
80CSNK1G20.79012134
81MAP3K90.73590753
82ADRBK10.73425452
83CSNK2A20.72593465
84MAP3K40.71615455
85NEK60.70945578
86NTRK20.70569570
87CDK50.69373956
88GRK10.68548265
89ATR0.67680930
90CAMKK20.67076998
91INSRR0.66369889
92CSNK2A10.65915157
93PRKCI0.65317896
94CCNB10.64693801
95CAMK2G0.64446056
96CSNK1G10.63929251
97PKN10.60845107
98YES10.60782653
99RAF10.60622334
100PRKCG0.60204104
101SYK0.59597751
102EPHB20.59437648
103ERBB30.59159606
104NTRK10.57864795
105IRAK40.56165016
106PHKG20.55027674
107PHKG10.55027674
108EIF2AK20.54209813
109PINK10.54146977
110DYRK1A0.53495275
111RPS6KA50.53471147
112IRAK20.53352406
113STK40.53019278
114OBSCN0.52155964
115CDK140.52116567
116CDK30.50007255
117MKNK20.49848012
118PRKACA0.49258701
119MAP4K20.49077217
120GRK60.48676592
121DAPK10.48143317
122MAP2K40.46575316
123CDK90.45618535
124CDK180.45342879
125MAPKAPK30.44907627
126ROCK20.44610058
127TXK0.44512429
128KDR0.44498929
129FGFR20.43997815
130PRKCQ0.43484203
131BLK0.43220423
132TLK10.41941332
133CDK70.41171211
134MOS0.41051025
135CDK150.40739986
136LYN0.40545812
137AKT30.40401362
138SRPK10.40283232
139TESK20.39448800
140DYRK30.39401564
141MAP3K110.39239805
142CSNK1A10.38734624
143CDK11A0.38673262
144IRAK10.38544670
145PRKG10.36955358
146MAP3K130.36298051
147PIK3CG0.35509495
148MKNK10.34065326
149EPHB10.33768821
150LRRK20.32502124
151PAK10.31683647
152CHEK10.29020276
153ATM0.26518173

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.95318195
2Parkinsons disease_Homo sapiens_hsa050124.73578174
3Alzheimers disease_Homo sapiens_hsa050103.90559677
4Protein export_Homo sapiens_hsa030603.65854384
5Huntingtons disease_Homo sapiens_hsa050163.38780807
6Proteasome_Homo sapiens_hsa030503.25898708
7Collecting duct acid secretion_Homo sapiens_hsa049663.04412012
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.95735628
9Ribosome_Homo sapiens_hsa030102.77081808
10DNA replication_Homo sapiens_hsa030302.53540726
11Mismatch repair_Homo sapiens_hsa034302.50101767
12Homologous recombination_Homo sapiens_hsa034402.24553904
13Cardiac muscle contraction_Homo sapiens_hsa042602.20169060
14Vibrio cholerae infection_Homo sapiens_hsa051102.17119724
15RNA polymerase_Homo sapiens_hsa030202.09063799
16Nicotine addiction_Homo sapiens_hsa050332.08642285
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96820930
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93085157
19Base excision repair_Homo sapiens_hsa034101.80494829
20Synaptic vesicle cycle_Homo sapiens_hsa047211.77348367
21Folate biosynthesis_Homo sapiens_hsa007901.76241554
22Rheumatoid arthritis_Homo sapiens_hsa053231.74694795
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63545452
24One carbon pool by folate_Homo sapiens_hsa006701.52960028
25Serotonergic synapse_Homo sapiens_hsa047261.48249781
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42753221
27Sulfur relay system_Homo sapiens_hsa041221.36064592
28Fanconi anemia pathway_Homo sapiens_hsa034601.33084069
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32703714
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30894089
31GABAergic synapse_Homo sapiens_hsa047271.24822507
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24758981
33RNA transport_Homo sapiens_hsa030131.24265190
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23525019
35Fatty acid elongation_Homo sapiens_hsa000621.22895677
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19892870
37Sulfur metabolism_Homo sapiens_hsa009201.14070778
38Taste transduction_Homo sapiens_hsa047421.13896195
39Phagosome_Homo sapiens_hsa041451.13583431
40Non-homologous end-joining_Homo sapiens_hsa034501.13097416
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08684067
42Morphine addiction_Homo sapiens_hsa050321.07440498
43Amphetamine addiction_Homo sapiens_hsa050311.04578151
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04549337
45Ether lipid metabolism_Homo sapiens_hsa005651.03535089
46Steroid biosynthesis_Homo sapiens_hsa001001.02004451
47Propanoate metabolism_Homo sapiens_hsa006401.01602182
48Glutamatergic synapse_Homo sapiens_hsa047241.01485250
49Phototransduction_Homo sapiens_hsa047440.97926704
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97498676
51Circadian entrainment_Homo sapiens_hsa047130.97225069
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.96088552
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90959392
54Selenocompound metabolism_Homo sapiens_hsa004500.87548568
55Cocaine addiction_Homo sapiens_hsa050300.84193831
56Long-term potentiation_Homo sapiens_hsa047200.83777475
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83582473
58Pyrimidine metabolism_Homo sapiens_hsa002400.83168207
59Dopaminergic synapse_Homo sapiens_hsa047280.82354827
60Vitamin B6 metabolism_Homo sapiens_hsa007500.80707913
61Long-term depression_Homo sapiens_hsa047300.79868544
62Peroxisome_Homo sapiens_hsa041460.79671520
63Sphingolipid metabolism_Homo sapiens_hsa006000.79098298
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78425533
65Carbon metabolism_Homo sapiens_hsa012000.73804356
66Type I diabetes mellitus_Homo sapiens_hsa049400.72744478
67Purine metabolism_Homo sapiens_hsa002300.67074252
68Butanoate metabolism_Homo sapiens_hsa006500.66816758
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65145246
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65101746
71Graft-versus-host disease_Homo sapiens_hsa053320.64516535
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64336768
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63915992
74Regulation of autophagy_Homo sapiens_hsa041400.63803542
75Biosynthesis of amino acids_Homo sapiens_hsa012300.62931790
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.62413474
77Renin secretion_Homo sapiens_hsa049240.62178364
78Insulin secretion_Homo sapiens_hsa049110.62020492
79Metabolic pathways_Homo sapiens_hsa011000.59607041
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59312210
81Calcium signaling pathway_Homo sapiens_hsa040200.59224078
82Cell cycle_Homo sapiens_hsa041100.58702721
83Olfactory transduction_Homo sapiens_hsa047400.56227462
84Cholinergic synapse_Homo sapiens_hsa047250.56160473
85Vitamin digestion and absorption_Homo sapiens_hsa049770.54597795
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53920646
87Asthma_Homo sapiens_hsa053100.53702385
88Salivary secretion_Homo sapiens_hsa049700.51275191
89Basal transcription factors_Homo sapiens_hsa030220.50982196
90Autoimmune thyroid disease_Homo sapiens_hsa053200.48087689
91African trypanosomiasis_Homo sapiens_hsa051430.47706434
92N-Glycan biosynthesis_Homo sapiens_hsa005100.46193565
93Chemical carcinogenesis_Homo sapiens_hsa052040.45495267
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.44301779
95Tryptophan metabolism_Homo sapiens_hsa003800.43410556
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42501529
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.42214285
98Galactose metabolism_Homo sapiens_hsa000520.42093581
99Lysosome_Homo sapiens_hsa041420.41676156
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40233052
101Linoleic acid metabolism_Homo sapiens_hsa005910.39827814
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39236121
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38747050
104Alcoholism_Homo sapiens_hsa050340.38696327
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36636907
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36622639
107Allograft rejection_Homo sapiens_hsa053300.36488054
108Arginine and proline metabolism_Homo sapiens_hsa003300.34586453
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34005753
110Oxytocin signaling pathway_Homo sapiens_hsa049210.33576850
111Axon guidance_Homo sapiens_hsa043600.33297816
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33285161
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.32099922
114Fatty acid metabolism_Homo sapiens_hsa012120.31371244
115Other glycan degradation_Homo sapiens_hsa005110.30886372
116mRNA surveillance pathway_Homo sapiens_hsa030150.28892936
117p53 signaling pathway_Homo sapiens_hsa041150.28675429
118Fatty acid degradation_Homo sapiens_hsa000710.28391799
119Fructose and mannose metabolism_Homo sapiens_hsa000510.28188269
120Gastric acid secretion_Homo sapiens_hsa049710.28109147
121Gap junction_Homo sapiens_hsa045400.28041474
122beta-Alanine metabolism_Homo sapiens_hsa004100.28019104
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27980709
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27350545
125Glutathione metabolism_Homo sapiens_hsa004800.27137130
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26042097
127Epstein-Barr virus infection_Homo sapiens_hsa051690.26007330
128GnRH signaling pathway_Homo sapiens_hsa049120.26000167
129Pertussis_Homo sapiens_hsa051330.26000080
130Oocyte meiosis_Homo sapiens_hsa041140.25491546
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23397623
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23318312
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20919586
134Retinol metabolism_Homo sapiens_hsa008300.19898580
135Pentose phosphate pathway_Homo sapiens_hsa000300.19435507
136Nucleotide excision repair_Homo sapiens_hsa034200.18728266
137Mineral absorption_Homo sapiens_hsa049780.18329209
138Arginine biosynthesis_Homo sapiens_hsa002200.17562552
139RNA degradation_Homo sapiens_hsa030180.16855927
140Pyruvate metabolism_Homo sapiens_hsa006200.16586894
141Pancreatic secretion_Homo sapiens_hsa049720.16287094
142Nitrogen metabolism_Homo sapiens_hsa009100.15542721
143Prion diseases_Homo sapiens_hsa050200.15053130
144Basal cell carcinoma_Homo sapiens_hsa052170.15035706
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14716474
146Systemic lupus erythematosus_Homo sapiens_hsa053220.13644480
147Ras signaling pathway_Homo sapiens_hsa040140.13273397
148Tuberculosis_Homo sapiens_hsa051520.12529130
149Tyrosine metabolism_Homo sapiens_hsa003500.12200160
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12169722
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11778140
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.11644966
153Spliceosome_Homo sapiens_hsa030400.11263849
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.11169426
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.11035876
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.10658565
157Salmonella infection_Homo sapiens_hsa051320.10640044
158Histidine metabolism_Homo sapiens_hsa003400.10205650
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09445674

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