TRAPPC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.87436031
2neuron cell-cell adhesion (GO:0007158)4.84870496
3presynaptic membrane assembly (GO:0097105)4.72798851
4presynaptic membrane organization (GO:0097090)4.52691536
5protein neddylation (GO:0045116)4.50412600
6central nervous system myelination (GO:0022010)4.46764220
7axon ensheathment in central nervous system (GO:0032291)4.46764220
8neuronal action potential propagation (GO:0019227)4.41073883
9fucose catabolic process (GO:0019317)4.38592442
10L-fucose metabolic process (GO:0042354)4.38592442
11L-fucose catabolic process (GO:0042355)4.38592442
12platelet dense granule organization (GO:0060155)4.35785300
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33188287
14synaptic vesicle exocytosis (GO:0016079)4.26519115
15response to pheromone (GO:0019236)4.20339883
16chaperone-mediated protein transport (GO:0072321)4.14746238
17long-chain fatty acid biosynthetic process (GO:0042759)4.09700355
18fatty acid elongation (GO:0030497)4.06349526
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01778463
20ATP hydrolysis coupled proton transport (GO:0015991)3.82731853
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.82731853
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81814106
23glutamate secretion (GO:0014047)3.65432594
24transferrin transport (GO:0033572)3.64225485
25respiratory chain complex IV assembly (GO:0008535)3.63720697
26regulation of synaptic vesicle exocytosis (GO:2000300)3.63192775
27negative regulation of neurotransmitter transport (GO:0051589)3.61558980
28ATP synthesis coupled proton transport (GO:0015986)3.60146793
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60146793
30vocalization behavior (GO:0071625)3.50771303
31neural tube formation (GO:0001841)3.46737482
32protein localization to synapse (GO:0035418)3.43525171
33respiratory electron transport chain (GO:0022904)3.43265013
34cellular ketone body metabolic process (GO:0046950)3.42717743
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.41225912
36ferric iron transport (GO:0015682)3.38804684
37trivalent inorganic cation transport (GO:0072512)3.38804684
38electron transport chain (GO:0022900)3.36414210
39DNA deamination (GO:0045006)3.33529905
40cytochrome complex assembly (GO:0017004)3.32384652
41negative regulation of dendrite morphogenesis (GO:0050774)3.30022875
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28272632
43pyrimidine nucleobase catabolic process (GO:0006208)3.22981489
44neurotransmitter uptake (GO:0001504)3.19594458
45postsynaptic membrane organization (GO:0001941)3.17590797
46neuron-neuron synaptic transmission (GO:0007270)3.15872539
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12968140
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.12344514
49indolalkylamine metabolic process (GO:0006586)3.12315414
50establishment of mitochondrion localization (GO:0051654)3.10329373
51ketone body metabolic process (GO:1902224)3.10136749
52negative regulation of neurotransmitter secretion (GO:0046929)3.09754727
53positive regulation of action potential (GO:0045760)3.09351837
54preassembly of GPI anchor in ER membrane (GO:0016254)3.08884088
55regulation of glucokinase activity (GO:0033131)3.08692438
56regulation of hexokinase activity (GO:1903299)3.08692438
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07981545
58regulation of synaptic vesicle transport (GO:1902803)3.07893707
59positive regulation of synapse assembly (GO:0051965)3.06202755
60water-soluble vitamin biosynthetic process (GO:0042364)3.06189506
61neurotransmitter-gated ion channel clustering (GO:0072578)3.05989847
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05020888
63axoneme assembly (GO:0035082)3.04502553
64detection of light stimulus involved in sensory perception (GO:0050962)3.02553363
65detection of light stimulus involved in visual perception (GO:0050908)3.02553363
66protein complex biogenesis (GO:0070271)3.01419019
67mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.00082536
68regulation of cilium movement (GO:0003352)2.99707473
69substantia nigra development (GO:0021762)2.99356291
70kynurenine metabolic process (GO:0070189)2.99065795
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97912327
72protein localization to cilium (GO:0061512)2.96505234
73transmission of nerve impulse (GO:0019226)2.96462723
74epithelial cilium movement (GO:0003351)2.96275781
75indole-containing compound catabolic process (GO:0042436)2.95916062
76indolalkylamine catabolic process (GO:0046218)2.95916062
77tryptophan catabolic process (GO:0006569)2.95916062
78replication fork processing (GO:0031297)2.94968924
79nucleobase catabolic process (GO:0046113)2.94703114
80anterograde synaptic vesicle transport (GO:0048490)2.94288595
81DNA double-strand break processing (GO:0000729)2.92693217
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92418995
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.92418995
84NADH dehydrogenase complex assembly (GO:0010257)2.92418995
85cornea development in camera-type eye (GO:0061303)2.92039031
86detection of temperature stimulus involved in sensory perception (GO:0050961)2.91829401
87detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.91829401
88startle response (GO:0001964)2.91663696
89phagosome maturation (GO:0090382)2.91261048
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91038326
91synaptic transmission, glutamatergic (GO:0035249)2.89766709
92long-term synaptic potentiation (GO:0060291)2.89021581
93positive regulation of mitochondrial fission (GO:0090141)2.86548770
94positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86045341
95dopamine transport (GO:0015872)2.85531530
96calcium-mediated signaling using intracellular calcium source (GO:0035584)2.84890384
97protein-cofactor linkage (GO:0018065)2.83265340
98regulation of glutamate secretion (GO:0014048)2.83089559
99neurotransmitter secretion (GO:0007269)2.81751608
100nonmotile primary cilium assembly (GO:0035058)2.81623381
101negative regulation of telomere maintenance (GO:0032205)2.81244132
102neuron recognition (GO:0008038)2.78331162
103ER overload response (GO:0006983)2.77058154
104membrane assembly (GO:0071709)2.76909024
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.76362432
106cilium morphogenesis (GO:0060271)2.75900593
107behavioral response to ethanol (GO:0048149)2.75680051
108cerebellar granule cell differentiation (GO:0021707)2.74744903
109synaptic vesicle docking involved in exocytosis (GO:0016081)2.74590700
110gamma-aminobutyric acid transport (GO:0015812)2.74567732
111piRNA metabolic process (GO:0034587)2.74334794
112adenosine metabolic process (GO:0046085)2.74141174
113cellular biogenic amine catabolic process (GO:0042402)2.74033686
114amine catabolic process (GO:0009310)2.74033686
115glutamate receptor signaling pathway (GO:0007215)2.73579932
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72330279
117keratinocyte development (GO:0003334)2.71473126
118protein K11-linked deubiquitination (GO:0035871)2.71157440
119cullin deneddylation (GO:0010388)2.70563534
120adult walking behavior (GO:0007628)2.69869782
121kidney morphogenesis (GO:0060993)2.69799490
122regulation of collateral sprouting (GO:0048670)2.69041894
123regulation of vesicle fusion (GO:0031338)2.68523022
124protein polyglutamylation (GO:0018095)2.68008348
125regulation of glutamate receptor signaling pathway (GO:1900449)2.67461396
126S-adenosylmethionine metabolic process (GO:0046500)2.67283445
127serotonin receptor signaling pathway (GO:0007210)2.67223579
128cilium organization (GO:0044782)2.66247954
129inositol phosphate catabolic process (GO:0071545)2.65443694
130regulation of synaptic transmission, GABAergic (GO:0032228)2.65298734
131hydrogen ion transmembrane transport (GO:1902600)2.65231317
132adaptation of signaling pathway (GO:0023058)2.64603876
133myelination (GO:0042552)2.63714258
134regulation of voltage-gated calcium channel activity (GO:1901385)2.63523129
135cilium assembly (GO:0042384)2.62183938
136glycerophospholipid catabolic process (GO:0046475)2.62167870
137dendrite development (GO:0016358)2.61510449
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61427998
139regulation of catecholamine metabolic process (GO:0042069)2.60658063
140regulation of dopamine metabolic process (GO:0042053)2.60658063
141neuronal action potential (GO:0019228)2.59847696
142neurotransmitter transport (GO:0006836)2.58914030
143regulation of synaptic transmission, glutamatergic (GO:0051966)2.58645553
144intraciliary transport (GO:0042073)2.58401730
145positive regulation of protein homodimerization activity (GO:0090073)2.58228191
146positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.57590650
147axon ensheathment (GO:0008366)2.57413639
148ensheathment of neurons (GO:0007272)2.57413639
149regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57004996
150negative regulation of DNA-dependent DNA replication (GO:2000104)2.56580214
151mitochondrial respiratory chain complex assembly (GO:0033108)2.56031900
152detection of calcium ion (GO:0005513)2.55722542
153response to redox state (GO:0051775)2.54135803
154rhodopsin mediated signaling pathway (GO:0016056)2.53495397
155mechanosensory behavior (GO:0007638)2.52936153
156negative regulation of synaptic transmission (GO:0050805)2.52921687
157detection of temperature stimulus (GO:0016048)2.52724102
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.52442104
159regulation of neurotransmitter secretion (GO:0046928)2.52378968
160regulation of action potential (GO:0098900)2.52316597
161reciprocal DNA recombination (GO:0035825)2.51703818
162reciprocal meiotic recombination (GO:0007131)2.51703818
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50818798
164negative regulation of translation, ncRNA-mediated (GO:0040033)2.50818798
165regulation of translation, ncRNA-mediated (GO:0045974)2.50818798
166GPI anchor metabolic process (GO:0006505)2.50494767
167tryptophan metabolic process (GO:0006568)2.48334041
168mannosylation (GO:0097502)2.44187319
169multicellular organism reproduction (GO:0032504)2.43910251
170negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43835286
171synaptic transmission, cholinergic (GO:0007271)2.43415577
172spinal cord motor neuron differentiation (GO:0021522)2.43311771
173limb bud formation (GO:0060174)2.42884766
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42495091
175protein prenylation (GO:0018342)2.42016843
176prenylation (GO:0097354)2.42016843
177recombinational repair (GO:0000725)2.41445280
178negative regulation of heart rate (GO:0010459)2.41294969
179photoreceptor cell development (GO:0042461)2.40170577
180polyol catabolic process (GO:0046174)2.40041274
181double-strand break repair via homologous recombination (GO:0000724)2.39355729
182G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39158312
183photoreceptor cell maintenance (GO:0045494)2.38201815
184indole-containing compound metabolic process (GO:0042430)2.36739236
185cilium movement (GO:0003341)2.36571269
186DNA methylation involved in gamete generation (GO:0043046)2.36081377
187retinal cone cell development (GO:0046549)2.35225968
188negative regulation of mast cell activation (GO:0033004)2.35141753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.42321964
2EZH2_22144423_ChIP-Seq_EOC_Human3.70790169
3ZNF274_21170338_ChIP-Seq_K562_Hela3.56280733
4TAF15_26573619_Chip-Seq_HEK293_Human3.19165285
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68077765
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64979311
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61199200
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48770071
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42744858
10VDR_22108803_ChIP-Seq_LS180_Human2.34877456
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20943316
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19713932
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16552427
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12799795
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.12436913
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12305704
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11984187
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10447636
19P300_19829295_ChIP-Seq_ESCs_Human2.03592888
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03241921
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.00972963
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99725796
23REST_21632747_ChIP-Seq_MESCs_Mouse1.99144844
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.99077099
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96024876
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92882658
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92882658
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90064491
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88974256
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86225320
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.84901283
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84403077
33FUS_26573619_Chip-Seq_HEK293_Human1.83352566
34SMAD4_21799915_ChIP-Seq_A2780_Human1.80409726
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80002473
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79891227
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71123402
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.69897825
39ER_23166858_ChIP-Seq_MCF-7_Human1.68816583
40BCAT_22108803_ChIP-Seq_LS180_Human1.68366615
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68210948
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67276382
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.66642659
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.65924345
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65741951
46IGF1R_20145208_ChIP-Seq_DFB_Human1.64754775
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64324129
48AR_21572438_ChIP-Seq_LNCaP_Human1.63800115
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.62048465
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60753530
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60571517
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59344262
53TP53_22573176_ChIP-Seq_HFKS_Human1.58398614
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.56799289
55IRF1_19129219_ChIP-ChIP_H3396_Human1.56746218
56RNF2_27304074_Chip-Seq_NSC_Mouse1.56115668
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.55506531
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.52390141
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47476085
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.43588106
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.41484844
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41456530
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40697231
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40639059
65CBP_20019798_ChIP-Seq_JUKART_Human1.40181365
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40181365
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.39823815
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39655120
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39515793
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.39127943
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.38602675
72MYC_18940864_ChIP-ChIP_HL60_Human1.34880651
73JUN_21703547_ChIP-Seq_K562_Human1.34674683
74ELK1_19687146_ChIP-ChIP_HELA_Human1.33765277
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.32310629
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31653502
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31507623
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30972041
79AR_25329375_ChIP-Seq_VCAP_Human1.30490265
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29493647
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29218813
82EWS_26573619_Chip-Seq_HEK293_Human1.27322404
83STAT3_23295773_ChIP-Seq_U87_Human1.27157879
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26713790
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.26038948
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26038948
87TCF4_22108803_ChIP-Seq_LS180_Human1.25814985
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23343266
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23280001
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23165588
91VDR_23849224_ChIP-Seq_CD4+_Human1.23160906
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.22533612
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22099158
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20948057
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.20852576
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20458562
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19350474
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.18914698
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18417527
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18417527
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.18228983
102P53_22387025_ChIP-Seq_ESCs_Mouse1.17678656
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17423553
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17350796
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16527684
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15586000
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.15469757
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15087556
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.14912713
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14813012
111TCF4_23295773_ChIP-Seq_U87_Human1.14710849
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13454479
113RUNX2_22187159_ChIP-Seq_PCA_Human1.12930423
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.12776087
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11673124
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.11564303
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11461788
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10806324
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.10396729
120NCOR_22424771_ChIP-Seq_293T_Human1.09897505
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09750991
122E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09531508
123KDM2B_26808549_Chip-Seq_REH_Human1.08368581
124GATA3_21878914_ChIP-Seq_MCF-7_Human1.08267531
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07809118
126P300_18555785_Chip-Seq_ESCs_Mouse1.07166162
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06373523
128AR_20517297_ChIP-Seq_VCAP_Human1.06258237
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06205176
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06015543
131* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05886582
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05032767
133SOX2_18555785_Chip-Seq_ESCs_Mouse1.04834003
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04781704
135HTT_18923047_ChIP-ChIP_STHdh_Human1.03792959
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03677901
137* SOX2_19829295_ChIP-Seq_ESCs_Human1.03253490
138* NANOG_19829295_ChIP-Seq_ESCs_Human1.03253490
139IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02342128
140NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01496510
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01496510
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00887050
143HOXB7_26014856_ChIP-Seq_BT474_Human0.97666822
144RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97601080
145DROSHA_22980978_ChIP-Seq_HELA_Human0.97078301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.02596667
2MP0004270_analgesia3.68035975
3MP0003195_calcinosis3.47352429
4MP0004859_abnormal_synaptic_plasticity3.34873652
5MP0001968_abnormal_touch/_nociception3.24608469
6MP0002735_abnormal_chemical_nociception3.20130990
7MP0002736_abnormal_nociception_after3.12994832
8MP0002102_abnormal_ear_morphology3.09773479
9MP0009046_muscle_twitch2.95209955
10MP0003635_abnormal_synaptic_transmissio2.93303327
11MP0001529_abnormal_vocalization2.86924217
12MP0002064_seizures2.84311871
13MP0009745_abnormal_behavioral_response2.81697306
14MP0002734_abnormal_mechanical_nocicepti2.79142360
15MP0006276_abnormal_autonomic_nervous2.76587215
16MP0002272_abnormal_nervous_system2.72942075
17MP0002572_abnormal_emotion/affect_behav2.44761003
18MP0002063_abnormal_learning/memory/cond2.41808202
19MP0001905_abnormal_dopamine_level2.40312321
20MP0000569_abnormal_digit_pigmentation2.36856493
21MP0001486_abnormal_startle_reflex2.20214351
22MP0001986_abnormal_taste_sensitivity2.20110709
23MP0001970_abnormal_pain_threshold2.15459911
24MP0002733_abnormal_thermal_nociception2.13281292
25MP0002067_abnormal_sensory_capabilities2.06028263
26MP0004142_abnormal_muscle_tone1.99917835
27MP0001440_abnormal_grooming_behavior1.99671785
28MP0005646_abnormal_pituitary_gland1.97618634
29MP0005084_abnormal_gallbladder_morpholo1.94386424
30MP0006292_abnormal_olfactory_placode1.92760693
31MP0001984_abnormal_olfaction1.87150465
32MP0005174_abnormal_tail_pigmentation1.85887684
33MP0000778_abnormal_nervous_system1.81146720
34MP0001501_abnormal_sleep_pattern1.80414102
35MP0001188_hyperpigmentation1.80145547
36MP0005423_abnormal_somatic_nervous1.76406440
37MP0000920_abnormal_myelination1.74731227
38MP0002938_white_spotting1.72263368
39MP0005171_absent_coat_pigmentation1.70946692
40MP0002822_catalepsy1.68350883
41MP0002184_abnormal_innervation1.65926273
42MP0005386_behavior/neurological_phenoty1.62673538
43MP0004924_abnormal_behavior1.62673538
44MP0005075_abnormal_melanosome_morpholog1.56453010
45MP0003329_amyloid_beta_deposits1.52074671
46MP0004742_abnormal_vestibular_system1.50236462
47MP0002876_abnormal_thyroid_physiology1.48709139
48MP0000427_abnormal_hair_cycle1.39618341
49MP0004133_heterotaxia1.38564776
50MP0002557_abnormal_social/conspecific_i1.37291446
51MP0000955_abnormal_spinal_cord1.35685157
52MP0003122_maternal_imprinting1.35617190
53MP0002882_abnormal_neuron_morphology1.35464085
54MP0002837_dystrophic_cardiac_calcinosis1.33454205
55MP0005645_abnormal_hypothalamus_physiol1.30905495
56MP0003136_yellow_coat_color1.30513575
57MP0010386_abnormal_urinary_bladder1.29496950
58MP0002066_abnormal_motor_capabilities/c1.29138182
59MP0008569_lethality_at_weaning1.27078613
60MP0003011_delayed_dark_adaptation1.26260487
61MP0001485_abnormal_pinna_reflex1.24625165
62MP0003787_abnormal_imprinting1.23928023
63MP0002229_neurodegeneration1.23601181
64MP0008058_abnormal_DNA_repair1.21898525
65MP0001963_abnormal_hearing_physiology1.21152198
66MP0003646_muscle_fatigue1.18388648
67MP0008875_abnormal_xenobiotic_pharmacok1.17856756
68MP0000015_abnormal_ear_pigmentation1.16458981
69MP0003634_abnormal_glial_cell1.16279707
70MP0004858_abnormal_nervous_system1.15521180
71MP0002653_abnormal_ependyma_morphology1.14344343
72MP0004811_abnormal_neuron_physiology1.14180242
73MP0003121_genomic_imprinting1.13031521
74MP0002928_abnormal_bile_duct1.12827478
75MP0001502_abnormal_circadian_rhythm1.12481725
76MP0002095_abnormal_skin_pigmentation1.10983625
77MP0009780_abnormal_chondrocyte_physiolo1.08953559
78MP0008260_abnormal_autophagy1.08879420
79MP0005551_abnormal_eye_electrophysiolog1.08015707
80MP0003879_abnormal_hair_cell1.06951057
81MP0008995_early_reproductive_senescence1.06742222
82MP0003718_maternal_effect1.06660919
83MP0002160_abnormal_reproductive_system1.04911256
84MP0002234_abnormal_pharynx_morphology1.04128756
85MP0004043_abnormal_pH_regulation1.03645989
86MP0002752_abnormal_somatic_nervous1.03299180
87MP0005389_reproductive_system_phenotype1.02809890
88MP0005409_darkened_coat_color1.02219590
89MP0003631_nervous_system_phenotype1.00750082
90MP0003690_abnormal_glial_cell1.00068742
91MP0003633_abnormal_nervous_system0.98067264
92MP0002909_abnormal_adrenal_gland0.97994479
93MP0003283_abnormal_digestive_organ0.95107437
94MP0000372_irregular_coat_pigmentation0.94084336
95MP0001324_abnormal_eye_pigmentation0.94027058
96MP0005195_abnormal_posterior_eye0.92884442
97MP0001764_abnormal_homeostasis0.92103698
98MP0005379_endocrine/exocrine_gland_phen0.90329827
99MP0002693_abnormal_pancreas_physiology0.89757329
100MP0004145_abnormal_muscle_electrophysio0.89747729
101MP0008775_abnormal_heart_ventricle0.89211757
102MP0003632_abnormal_nervous_system0.89033648
103MP0000026_abnormal_inner_ear0.88730342
104MP0001919_abnormal_reproductive_system0.88444834
105MP0002277_abnormal_respiratory_mucosa0.86258340
106MP0000230_abnormal_systemic_arterial0.85034522
107MP0002163_abnormal_gland_morphology0.84839588
108MP0002751_abnormal_autonomic_nervous0.83405010
109MP0000751_myopathy0.83351498
110MP0003698_abnormal_male_reproductive0.83122795
111MP0000631_abnormal_neuroendocrine_gland0.82856183
112MP0010329_abnormal_lipoprotein_level0.82494849
113MP0003890_abnormal_embryonic-extraembry0.82087844
114MP0000013_abnormal_adipose_tissue0.81307187
115MP0002638_abnormal_pupillary_reflex0.81028407
116MP0006036_abnormal_mitochondrial_physio0.80898857
117MP0004885_abnormal_endolymph0.80773325
118MP0002152_abnormal_brain_morphology0.80624442
119MP0005410_abnormal_fertilization0.79800289
120MP0000647_abnormal_sebaceous_gland0.78783151
121MP0000516_abnormal_urinary_system0.78757672
122MP0005367_renal/urinary_system_phenotyp0.78757672
123MP0005394_taste/olfaction_phenotype0.78385326
124MP0005499_abnormal_olfactory_system0.78385326
125MP0000383_abnormal_hair_follicle0.77197438
126MP0004085_abnormal_heartbeat0.74945454
127MP0003950_abnormal_plasma_membrane0.71623857
128MP0008872_abnormal_physiological_respon0.70400177
129MP0004147_increased_porphyrin_level0.69976742
130MP0004036_abnormal_muscle_relaxation0.69138302
131MP0008877_abnormal_DNA_methylation0.68803012
132MP0001664_abnormal_digestion0.68766597
133MP0002069_abnormal_eating/drinking_beha0.67763566
134MP0006072_abnormal_retinal_apoptosis0.67406401
135MP0008789_abnormal_olfactory_epithelium0.66070252
136MP0004484_altered_response_of0.64649217
137MP0009697_abnormal_copulation0.64303011
138MP0006035_abnormal_mitochondrial_morpho0.61162166
139MP0000604_amyloidosis0.60990794
140MP0004215_abnormal_myocardial_fiber0.58941808
141MP0005253_abnormal_eye_physiology0.58184389
142MP0001299_abnormal_eye_distance/0.57502590

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.96124444
2Atonic seizures (HP:0010819)4.96572616
3Acute necrotizing encephalopathy (HP:0006965)4.80926336
4Abnormal mitochondria in muscle tissue (HP:0008316)4.32517830
5Myokymia (HP:0002411)4.29165424
6Pancreatic cysts (HP:0001737)4.18567894
7Progressive macrocephaly (HP:0004481)4.11981314
8Increased serum pyruvate (HP:0003542)3.99099526
9Abnormality of glycolysis (HP:0004366)3.99099526
10Mitochondrial inheritance (HP:0001427)3.97686129
11Epileptic encephalopathy (HP:0200134)3.94591200
12Abnormality of midbrain morphology (HP:0002418)3.93425760
13Molar tooth sign on MRI (HP:0002419)3.93425760
14Acute encephalopathy (HP:0006846)3.77963016
15Pancreatic fibrosis (HP:0100732)3.76347341
16Febrile seizures (HP:0002373)3.71139828
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.57616005
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.57616005
19Pheochromocytoma (HP:0002666)3.57133687
20Congenital stationary night blindness (HP:0007642)3.54145262
21True hermaphroditism (HP:0010459)3.53696450
22Focal seizures (HP:0007359)3.51189214
23Hyperventilation (HP:0002883)3.47940146
24Abnormal hair whorl (HP:0010721)3.45869318
25Gait imbalance (HP:0002141)3.40242213
26Neuroendocrine neoplasm (HP:0100634)3.39788119
27Increased CSF lactate (HP:0002490)3.36893375
28Nephronophthisis (HP:0000090)3.35382741
29Medial flaring of the eyebrow (HP:0010747)3.34034064
30Hepatocellular necrosis (HP:0001404)3.32797612
31Absence seizures (HP:0002121)3.28409870
32Sensory axonal neuropathy (HP:0003390)3.26763477
33Congenital primary aphakia (HP:0007707)3.22938057
34Abnormality of the renal cortex (HP:0011035)3.21555662
35Dialeptic seizures (HP:0011146)3.15897870
36Hypothermia (HP:0002045)3.10365720
37Nephrogenic diabetes insipidus (HP:0009806)3.03352829
38Vaginal atresia (HP:0000148)2.89825841
39Abnormality of the corticospinal tract (HP:0002492)2.89508844
40Genital tract atresia (HP:0001827)2.89498034
41Leukodystrophy (HP:0002415)2.89001820
42Abnormality of the renal medulla (HP:0100957)2.87646909
43Renal cortical cysts (HP:0000803)2.86845314
44Polydipsia (HP:0001959)2.81346334
45Abnormal drinking behavior (HP:0030082)2.81346334
46Progressive cerebellar ataxia (HP:0002073)2.78877943
47Parakeratosis (HP:0001036)2.77022538
48Generalized tonic-clonic seizures (HP:0002069)2.75210874
49Optic disc pallor (HP:0000543)2.73480872
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62354975
51Abnormality of alanine metabolism (HP:0010916)2.62354975
52Hyperalaninemia (HP:0003348)2.62354975
53Attenuation of retinal blood vessels (HP:0007843)2.59795648
54Type II lissencephaly (HP:0007260)2.56264971
55Autoamputation (HP:0001218)2.52635610
56Insidious onset (HP:0003587)2.52162129
57Termporal pattern (HP:0011008)2.52162129
58Limb dystonia (HP:0002451)2.49760769
59Hypomagnesemia (HP:0002917)2.46677217
60Neurofibrillary tangles (HP:0002185)2.45630182
61Abolished electroretinogram (ERG) (HP:0000550)2.44923280
62Renal Fanconi syndrome (HP:0001994)2.44196256
63Hepatic necrosis (HP:0002605)2.43819027
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.43240733
65Chronic hepatic failure (HP:0100626)2.39235502
66Polyphagia (HP:0002591)2.38424148
67Increased hepatocellular lipid droplets (HP:0006565)2.37781617
68Progressive inability to walk (HP:0002505)2.36410888
69Poor coordination (HP:0002370)2.33671397
70Large for gestational age (HP:0001520)2.32005812
71Lissencephaly (HP:0001339)2.30741322
72Scanning speech (HP:0002168)2.30404403
73Poor suck (HP:0002033)2.28802017
74Visual hallucinations (HP:0002367)2.28188185
75Cystic liver disease (HP:0006706)2.28090952
76Respiratory failure (HP:0002878)2.25744558
77Spastic gait (HP:0002064)2.25422171
78Akinesia (HP:0002304)2.24662809
79Broad-based gait (HP:0002136)2.24175439
80Pendular nystagmus (HP:0012043)2.24107882
81Supranuclear gaze palsy (HP:0000605)2.21652096
82Decreased central vision (HP:0007663)2.21230062
83Abnormal eating behavior (HP:0100738)2.21208206
84Gaze-evoked nystagmus (HP:0000640)2.19719225
85Abnormal rod and cone electroretinograms (HP:0008323)2.18180912
86Specific learning disability (HP:0001328)2.17473573
87Cerebral edema (HP:0002181)2.17458107
88Retinal dysplasia (HP:0007973)2.17451082
89Polyuria (HP:0000103)2.17308971
90Dysmetria (HP:0001310)2.16872507
91Peripheral hypomyelination (HP:0007182)2.16799620
92X-linked dominant inheritance (HP:0001423)2.15330926
93Ulnar claw (HP:0001178)2.14265037
94Sclerocornea (HP:0000647)2.09912108
95Failure to thrive in infancy (HP:0001531)2.09757442
96Lactic acidosis (HP:0003128)2.08658434
97Furrowed tongue (HP:0000221)2.08036835
98Thyroiditis (HP:0100646)2.07596111
99Ankle clonus (HP:0011448)2.07407590
100Congenital, generalized hypertrichosis (HP:0004540)2.06834656
101Truncal ataxia (HP:0002078)2.06182483
102Exercise intolerance (HP:0003546)2.05900198
103Anencephaly (HP:0002323)2.03427098
104Aplasia/Hypoplasia of the lens (HP:0008063)2.02976878
105Tubular atrophy (HP:0000092)2.02593257
106Abnormality of the labia minora (HP:0012880)2.02112965
107Ketoacidosis (HP:0001993)2.00602788
108Male pseudohermaphroditism (HP:0000037)1.99148506
109Action tremor (HP:0002345)1.98698639
110Pachygyria (HP:0001302)1.98673642
111Esotropia (HP:0000565)1.98420703
112Anxiety (HP:0000739)1.96342389
113Abnormal biliary tract physiology (HP:0012439)1.95489853
114Bile duct proliferation (HP:0001408)1.95489853
115Delusions (HP:0000746)1.95338730
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.93260340
117Poor speech (HP:0002465)1.93032151
118Abnormality of the pons (HP:0007361)1.92934867
119Amblyopia (HP:0000646)1.92379551
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.92374260
121Cerebral hypomyelination (HP:0006808)1.91784783
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91647524
123Congenital hepatic fibrosis (HP:0002612)1.91060729
124Cerebral hemorrhage (HP:0001342)1.90240370
125Lipid accumulation in hepatocytes (HP:0006561)1.90138790
126Fetal akinesia sequence (HP:0001989)1.89520556
127Inability to walk (HP:0002540)1.88992637
128Epileptiform EEG discharges (HP:0011182)1.88801869
129Generalized myoclonic seizures (HP:0002123)1.88565901
1303-Methylglutaconic aciduria (HP:0003535)1.86917512
131Methylmalonic aciduria (HP:0012120)1.83837631
132Thickened helices (HP:0000391)1.83598454
133Postaxial foot polydactyly (HP:0001830)1.81752538
134Optic nerve hypoplasia (HP:0000609)1.81577460
135Intestinal atresia (HP:0011100)1.81324023
136Diminished movement (HP:0002374)1.81143595
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80987177
138Methylmalonic acidemia (HP:0002912)1.80338751
139Tachypnea (HP:0002789)1.79669356
140Hemiparesis (HP:0001269)1.79499523
141Absent speech (HP:0001344)1.79402596
142Cerebral inclusion bodies (HP:0100314)1.77936812
143Stomach cancer (HP:0012126)1.77935510
144Hypoplasia of the pons (HP:0012110)1.77649897
145Dysdiadochokinesis (HP:0002075)1.77297596
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75522979
147Increased serum lactate (HP:0002151)1.74296596
148Impaired vibration sensation in the lower limbs (HP:0002166)1.73989253
149Ketosis (HP:0001946)1.72725106
150Postaxial hand polydactyly (HP:0001162)1.72587641
151Absent/shortened dynein arms (HP:0200106)1.72463580
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.72463580
153Abnormal respiratory motile cilium morphology (HP:0005938)1.71545207
154Abnormal respiratory epithelium morphology (HP:0012253)1.71545207
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.70659114
156EEG with generalized epileptiform discharges (HP:0011198)1.69676760
157Blue irides (HP:0000635)1.69349742
158Abnormality of magnesium homeostasis (HP:0004921)1.69010080
159Abnormal ciliary motility (HP:0012262)1.68506878
160Abnormality of urine glucose concentration (HP:0011016)1.68363800
161Glycosuria (HP:0003076)1.68363800
162Concave nail (HP:0001598)1.67760395
163Abnormal albumin level (HP:0012116)1.66398920
164Hypoalbuminemia (HP:0003073)1.66398920
165Hypoplasia of the fovea (HP:0007750)1.65551833
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.65551833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.28280242
2CASK5.20914979
3MAP3K123.36952891
4MAP4K22.79986659
5NTRK32.75499855
6MAP2K72.68825030
7OXSR12.67881151
8STK392.61716488
9BCR2.44536068
10NUAK12.35221559
11MAP3K42.30184686
12ACVR1B2.24904101
13CDK192.17663076
14ZAK2.16389963
15GRK12.06224676
16TRIM282.05249297
17EPHA42.03745333
18PLK22.03620509
19ARAF2.02418820
20TNIK1.84855140
21TAOK31.80094077
22INSRR1.76610653
23MINK11.74903742
24PRPF4B1.73348971
25GRK51.69166941
26NME11.56773937
27MAPK131.55495156
28MST41.50826632
29MKNK21.49161469
30TLK11.48216219
31LIMK11.46815068
32AKT31.46336724
33SIK31.45346111
34MARK11.39397778
35MAP2K41.37302830
36MUSK1.35217605
37NTRK11.34792441
38ADRBK21.33499774
39BMPR1B1.33219374
40SGK2231.29115312
41SGK4941.29115312
42MAPKAPK51.27019532
43BMPR21.25139401
44FGFR21.22547816
45GRK71.20114152
46PNCK1.19258738
47CAMK2B1.18017093
48ERBB31.15993496
49TXK1.15063900
50TSSK61.14606763
51WNK41.14397243
52CAMK2A1.13750262
53MAP3K91.11938631
54BRAF1.11012438
55BRSK21.07796093
56RIPK41.04786221
57PRKCE1.02865219
58UHMK11.02295627
59TEC0.97466050
60CDK50.96196704
61STK160.94877751
62DAPK20.91230000
63PKN10.90813419
64PRKCG0.89977569
65NTRK20.89874016
66CCNB10.88233188
67ERBB40.88057986
68CSNK1G30.88028418
69PBK0.86544469
70MKNK10.86510835
71MYLK0.86015279
72STK38L0.84779775
73PLK30.84571325
74NEK60.84504326
75CAMK2D0.84198811
76CSNK1G20.82730857
77FGR0.81881427
78CDK140.80170366
79DAPK10.79747276
80TGFBR10.78228326
81PAK60.77840086
82STK30.76670290
83CDK180.76348375
84VRK20.73275045
85SGK20.73256036
86CAMK2G0.72337105
87WNK10.71170848
88PTK2B0.71006129
89DYRK20.70756362
90ADRBK10.70361983
91ROCK20.69735837
92FES0.66366976
93CDK150.65873356
94CDK80.64168668
95PDK20.63851552
96PHKG20.61910199
97PHKG10.61910199
98CAMKK20.60636746
99KSR20.60216319
100YES10.57212144
101NLK0.56551803
102PLK40.55566090
103PDK40.55160012
104PDK30.55160012
105KSR10.54908377
106CDK11A0.54775205
107WEE10.54389342
108CSNK1A1L0.53865848
109PAK30.52413166
110PIK3CA0.51971322
111BCKDK0.51228239
112IKBKB0.50620534
113PRKACA0.49870194
114DYRK30.49380130
115CDK30.48065055
116CSNK1G10.48036199
117DYRK1A0.45751283
118WNK30.44613145
119ITK0.44519849
120RPS6KA50.42499650
121PRKCI0.42179020
122MARK30.41329066
123MAPKAPK30.40591431
124PINK10.39129690
125EIF2AK10.39020951
126TNK20.38118443
127STK110.37483674
128SYK0.37397451
129MAP2K10.36859535
130PRKCQ0.36374791
131TIE10.35990685
132PRKG10.35948291
133TAF10.35886938
134FLT30.35542811
135CSNK1D0.34987184
136MAP3K60.33771295
137PASK0.33543455
138CSNK1A10.32721970
139FER0.32391119
140MAPK150.31799063
141PRKCA0.30370392
142IRAK10.29825973
143PLK10.29820792
144SGK10.29788763
145CAMK10.29642613
146VRK10.29067079
147EIF2AK30.26110650

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.27782019
2Collecting duct acid secretion_Homo sapiens_hsa049663.60898254
3Synaptic vesicle cycle_Homo sapiens_hsa047213.31293916
4Parkinsons disease_Homo sapiens_hsa050123.21104849
5Nicotine addiction_Homo sapiens_hsa050333.13876203
6Alzheimers disease_Homo sapiens_hsa050102.69086557
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.47562751
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.45277442
9Nitrogen metabolism_Homo sapiens_hsa009102.39259529
10Vibrio cholerae infection_Homo sapiens_hsa051102.37136954
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26118153
12Huntingtons disease_Homo sapiens_hsa050162.20114882
13GABAergic synapse_Homo sapiens_hsa047272.12614440
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10557323
15Fatty acid elongation_Homo sapiens_hsa000622.03382562
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90687493
17Serotonergic synapse_Homo sapiens_hsa047261.89887999
18Morphine addiction_Homo sapiens_hsa050321.89787649
19Homologous recombination_Homo sapiens_hsa034401.88878045
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83004152
21Glutamatergic synapse_Homo sapiens_hsa047241.79474437
22Olfactory transduction_Homo sapiens_hsa047401.75017294
23Protein export_Homo sapiens_hsa030601.71905824
24Taste transduction_Homo sapiens_hsa047421.70359500
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70209116
26Circadian entrainment_Homo sapiens_hsa047131.68422814
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.65689292
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65636014
29Steroid biosynthesis_Homo sapiens_hsa001001.63921538
30Dopaminergic synapse_Homo sapiens_hsa047281.61373204
31Fanconi anemia pathway_Homo sapiens_hsa034601.60224309
32Cardiac muscle contraction_Homo sapiens_hsa042601.59792480
33Amphetamine addiction_Homo sapiens_hsa050311.59678231
34Proteasome_Homo sapiens_hsa030501.54656014
35Rheumatoid arthritis_Homo sapiens_hsa053231.54469814
36Caffeine metabolism_Homo sapiens_hsa002321.52479831
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51209022
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50976615
39Selenocompound metabolism_Homo sapiens_hsa004501.49443962
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49399185
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48923660
42Long-term potentiation_Homo sapiens_hsa047201.46962625
43Propanoate metabolism_Homo sapiens_hsa006401.45581199
44Ether lipid metabolism_Homo sapiens_hsa005651.39997333
45Tryptophan metabolism_Homo sapiens_hsa003801.38585078
46Long-term depression_Homo sapiens_hsa047301.37769587
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25335431
48Insulin secretion_Homo sapiens_hsa049111.22479797
49RNA degradation_Homo sapiens_hsa030181.19909685
50Phototransduction_Homo sapiens_hsa047441.19655182
51Phagosome_Homo sapiens_hsa041451.18485955
52Salivary secretion_Homo sapiens_hsa049701.17007205
53Peroxisome_Homo sapiens_hsa041461.16597363
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16422936
55Non-homologous end-joining_Homo sapiens_hsa034501.11785046
56Cholinergic synapse_Homo sapiens_hsa047251.11181315
57Cocaine addiction_Homo sapiens_hsa050301.07787436
58Axon guidance_Homo sapiens_hsa043601.06076038
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05695668
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02437448
61Renin secretion_Homo sapiens_hsa049241.02181584
62Calcium signaling pathway_Homo sapiens_hsa040201.01479082
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.00340836
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95965041
65Chemical carcinogenesis_Homo sapiens_hsa052040.95250893
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94366955
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92401392
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91499782
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90645312
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.87716730
71Pyruvate metabolism_Homo sapiens_hsa006200.87671924
72Sulfur metabolism_Homo sapiens_hsa009200.87292782
73Gastric acid secretion_Homo sapiens_hsa049710.85287414
74Purine metabolism_Homo sapiens_hsa002300.79742165
75Retinol metabolism_Homo sapiens_hsa008300.79485103
76One carbon pool by folate_Homo sapiens_hsa006700.76903496
77ABC transporters_Homo sapiens_hsa020100.76748590
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76426379
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72580794
80Sphingolipid metabolism_Homo sapiens_hsa006000.72461228
81Regulation of autophagy_Homo sapiens_hsa041400.72173234
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72034439
83Oxytocin signaling pathway_Homo sapiens_hsa049210.71933141
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70214265
85beta-Alanine metabolism_Homo sapiens_hsa004100.69746924
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67760748
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.67516997
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.67154771
89Primary immunodeficiency_Homo sapiens_hsa053400.66213042
90Type I diabetes mellitus_Homo sapiens_hsa049400.63612426
91Fat digestion and absorption_Homo sapiens_hsa049750.63011089
92Vitamin B6 metabolism_Homo sapiens_hsa007500.61700637
93Gap junction_Homo sapiens_hsa045400.61555614
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61099996
95GnRH signaling pathway_Homo sapiens_hsa049120.58953831
96cAMP signaling pathway_Homo sapiens_hsa040240.56664540
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56003190
98Glycerolipid metabolism_Homo sapiens_hsa005610.55463376
99Ras signaling pathway_Homo sapiens_hsa040140.54258803
100ErbB signaling pathway_Homo sapiens_hsa040120.53926996
101Butanoate metabolism_Homo sapiens_hsa006500.51866307
102Mineral absorption_Homo sapiens_hsa049780.49299231
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48221673
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47409492
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46353180
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43588517
107Nucleotide excision repair_Homo sapiens_hsa034200.42498149
108Pyrimidine metabolism_Homo sapiens_hsa002400.42399863
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41338610
110Hedgehog signaling pathway_Homo sapiens_hsa043400.41110651
111RNA polymerase_Homo sapiens_hsa030200.39540160
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38131357
113Pancreatic secretion_Homo sapiens_hsa049720.37617041
114Autoimmune thyroid disease_Homo sapiens_hsa053200.36565893
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35576307
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.35356314
117Metabolic pathways_Homo sapiens_hsa011000.34611529
118Linoleic acid metabolism_Homo sapiens_hsa005910.34566392
119Melanogenesis_Homo sapiens_hsa049160.34127096
120MAPK signaling pathway_Homo sapiens_hsa040100.33676928
121Ovarian steroidogenesis_Homo sapiens_hsa049130.30823974
122Vitamin digestion and absorption_Homo sapiens_hsa049770.30793925
123Oocyte meiosis_Homo sapiens_hsa041140.30602381
124Alcoholism_Homo sapiens_hsa050340.30458392
125Asthma_Homo sapiens_hsa053100.29656896
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29571851
127Mismatch repair_Homo sapiens_hsa034300.29373004
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28238432
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28149421
130Histidine metabolism_Homo sapiens_hsa003400.25339214
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24196575
132Estrogen signaling pathway_Homo sapiens_hsa049150.22829818
133Circadian rhythm_Homo sapiens_hsa047100.22486660
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22431194
135Basal transcription factors_Homo sapiens_hsa030220.21777927
136African trypanosomiasis_Homo sapiens_hsa051430.21205531
137Endocytosis_Homo sapiens_hsa041440.20948143
138Melanoma_Homo sapiens_hsa052180.19874831
139Arachidonic acid metabolism_Homo sapiens_hsa005900.19476069
140Renal cell carcinoma_Homo sapiens_hsa052110.19126279
141Dorso-ventral axis formation_Homo sapiens_hsa043200.18678756
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.18463711
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.16293202
144Choline metabolism in cancer_Homo sapiens_hsa052310.16070423

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »