TRAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)4.00495539
2sequestering of extracellular ligand from receptor (GO:0035581)3.98563876
3regulation of plasminogen activation (GO:0010755)3.82059877
4cell-substrate junction assembly (GO:0007044)3.75637142
5endocardial cushion development (GO:0003197)3.74769708
6type B pancreatic cell proliferation (GO:0044342)3.63935078
7negative regulation of fatty acid transport (GO:2000192)3.56164122
8chondrocyte proliferation (GO:0035988)3.48050637
9kidney mesenchyme development (GO:0072074)3.47349222
10fibril organization (GO:0097435)3.45618338
11extracellular matrix assembly (GO:0085029)3.40878989
12lymph vessel development (GO:0001945)3.40767981
13protein localization to endosome (GO:0036010)3.40155767
14cell migration involved in sprouting angiogenesis (GO:0002042)3.38580531
15protein heterotrimerization (GO:0070208)3.37476802
16extracellular fibril organization (GO:0043206)3.36460535
17heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.35850906
18positive regulation of extracellular matrix organization (GO:1903055)3.34671831
19cellular response to vitamin (GO:0071295)3.33488612
20focal adhesion assembly (GO:0048041)3.31641111
21cell-substrate adherens junction assembly (GO:0007045)3.31641111
22hypotonic response (GO:0006971)3.27911727
23adherens junction assembly (GO:0034333)3.22889361
24negative regulation of fibrinolysis (GO:0051918)3.19340498
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17985955
26stress fiber assembly (GO:0043149)3.14072940
27COPII vesicle coating (GO:0048208)3.13243409
28barbed-end actin filament capping (GO:0051016)3.10476597
29actin filament depolymerization (GO:0030042)3.10181689
30extracellular matrix disassembly (GO:0022617)3.08269554
31basement membrane organization (GO:0071711)3.06789471
32hyaluronan catabolic process (GO:0030214)3.05751605
33regulation of extracellular matrix disassembly (GO:0010715)3.05366393
34definitive hemopoiesis (GO:0060216)3.00590106
35hemidesmosome assembly (GO:0031581)2.98096031
36adhesion of symbiont to host cell (GO:0044650)2.98062497
37virion attachment to host cell (GO:0019062)2.98062497
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97922430
39peptidyl-proline hydroxylation (GO:0019511)2.96856429
40glomerular basement membrane development (GO:0032836)2.95527279
41dermatan sulfate biosynthetic process (GO:0030208)2.94029727
42adhesion of symbiont to host (GO:0044406)2.93467841
43pinocytosis (GO:0006907)2.92436187
44cellular response to vitamin D (GO:0071305)2.92095825
45bone trabecula formation (GO:0060346)2.91675894
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91140585
47negative regulation of osteoblast proliferation (GO:0033689)2.89800799
48blood vessel endothelial cell migration (GO:0043534)2.89488170
49metanephric mesenchyme development (GO:0072075)2.88437031
50glomerular filtration (GO:0003094)2.88422701
51protein hydroxylation (GO:0018126)2.87538054
52membrane raft organization (GO:0031579)2.86410240
53* multicellular organismal metabolic process (GO:0044236)2.86305254
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86018707
55blood vessel maturation (GO:0001955)2.85835946
56positive regulation of fibroblast migration (GO:0010763)2.81837321
57sprouting angiogenesis (GO:0002040)2.80652498
58extracellular matrix organization (GO:0030198)2.78214119
59peptidyl-glutamic acid carboxylation (GO:0017187)2.77962310
60protein carboxylation (GO:0018214)2.77962310
61dermatan sulfate metabolic process (GO:0030205)2.77183583
62extracellular structure organization (GO:0043062)2.77123416
63vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76955037
64chondrocyte development (GO:0002063)2.76621974
65positive regulation of endothelial cell migration (GO:0010595)2.75262792
66keratan sulfate catabolic process (GO:0042340)2.74727971
67positive regulation of epithelial to mesenchymal transition (GO:0010718)2.74395000
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73517276
69negative regulation of anoikis (GO:2000811)2.73403395
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72702103
71endodermal cell differentiation (GO:0035987)2.70512760
72positive regulation of cartilage development (GO:0061036)2.69526602
73wound healing, spreading of epidermal cells (GO:0035313)2.69076859
74vesicle coating (GO:0006901)2.65651195
75positive regulation of osteoblast proliferation (GO:0033690)2.65587284
76glomerulus development (GO:0032835)2.65508457
77epithelial cell-cell adhesion (GO:0090136)2.64917001
78protein retention in ER lumen (GO:0006621)2.64238682
79renal filtration (GO:0097205)2.62942368
80regulation of early endosome to late endosome transport (GO:2000641)2.62478569
81regulation of interleukin-8 secretion (GO:2000482)2.62188267
82angiogenesis involved in wound healing (GO:0060055)2.61689973
83negative regulation of chondrocyte differentiation (GO:0032331)2.60832049
84muscle cell migration (GO:0014812)2.58307280
85venous blood vessel morphogenesis (GO:0048845)2.56059571
86negative regulation of phagocytosis (GO:0050765)2.54155662
87Notch signaling involved in heart development (GO:0061314)2.50431766
88endothelial cell morphogenesis (GO:0001886)2.48806593
89cell proliferation involved in metanephros development (GO:0072203)2.47659950
90skin morphogenesis (GO:0043589)2.45524003
91cell adhesion mediated by integrin (GO:0033627)2.45493441
92positive regulation of protein import into nucleus, translocation (GO:0033160)2.44697465
93neuron projection extension involved in neuron projection guidance (GO:1902284)2.44303515
94axon extension involved in axon guidance (GO:0048846)2.44303515
95positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44195811
96cell proliferation involved in kidney development (GO:0072111)2.43169501
97vascular endothelial growth factor signaling pathway (GO:0038084)2.43029483
98regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41797473
99negative regulation of biomineral tissue development (GO:0070168)2.39413566
100response to interferon-alpha (GO:0035455)2.38552317
101extracellular regulation of signal transduction (GO:1900115)2.35227593
102extracellular negative regulation of signal transduction (GO:1900116)2.35227593
103regulation of protein heterodimerization activity (GO:0043497)2.33613103
104chondroitin sulfate biosynthetic process (GO:0030206)2.33458174
105fibroblast migration (GO:0010761)2.33008779
106epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.30800052
107pericardium development (GO:0060039)2.29378903
108* collagen metabolic process (GO:0032963)2.26738584
109collagen catabolic process (GO:0030574)2.25067640
110radial glial cell differentiation (GO:0060019)2.24675340
111notochord development (GO:0030903)2.24603567
112positive regulation of stem cell differentiation (GO:2000738)2.22752497
113positive regulation of interferon-alpha production (GO:0032727)2.22461732
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21476227
115mesodermal cell differentiation (GO:0048333)2.21027966
116wound healing, spreading of cells (GO:0044319)2.20859085
117signal peptide processing (GO:0006465)2.20178552
118UDP-N-acetylglucosamine metabolic process (GO:0006047)2.18020250
119mesenchymal-epithelial cell signaling (GO:0060638)2.17290896
120substrate adhesion-dependent cell spreading (GO:0034446)2.17007059
121regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.15820225
122Golgi transport vesicle coating (GO:0048200)2.14773711
123COPI coating of Golgi vesicle (GO:0048205)2.14773711
124positive regulation of endothelial cell apoptotic process (GO:2000353)2.14583857
125negative regulation of cartilage development (GO:0061037)2.14190250
126mRNA transcription (GO:0009299)2.14107656
127lymphangiogenesis (GO:0001946)2.13488953
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13267223
129atrioventricular valve morphogenesis (GO:0003181)2.12370586
130regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.11806881
131substrate-dependent cell migration (GO:0006929)2.10315343
132regulation of interferon-alpha production (GO:0032647)2.09903206
133negative regulation of smooth muscle cell migration (GO:0014912)2.09772642
134paraxial mesoderm development (GO:0048339)2.09420027
135positive regulation of blood vessel endothelial cell migration (GO:0043536)2.08700533
136apoptotic cell clearance (GO:0043277)2.08008225
137mesenchymal cell development (GO:0014031)2.07457777
138regulation of osteoblast proliferation (GO:0033688)2.07214527
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.06948680
140positive regulation of BMP signaling pathway (GO:0030513)2.06609835
141endocardial cushion morphogenesis (GO:0003203)2.06345554
142mesenchyme morphogenesis (GO:0072132)2.05115654
143smooth muscle tissue development (GO:0048745)2.05081822
144regulation of apoptotic cell clearance (GO:2000425)2.04663289
145* multicellular organismal macromolecule metabolic process (GO:0044259)2.03121280
146cell migration involved in heart development (GO:0060973)2.02809729
147histamine secretion (GO:0001821)2.02569555
148multicellular organismal catabolic process (GO:0044243)2.01322199
149complement activation, classical pathway (GO:0006958)2.00789380
150regulation of RIG-I signaling pathway (GO:0039535)2.00430524
151epithelial to mesenchymal transition (GO:0001837)2.00406007
152morphogenesis of an endothelium (GO:0003159)1.99758949
153endothelial tube morphogenesis (GO:0061154)1.99758949
154positive regulation of type I interferon-mediated signaling pathway (GO:0060340)1.99539871
155positive regulation of vasculogenesis (GO:2001214)1.99279267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.58858930
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.37862970
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.90534232
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90396020
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.64382105
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.47619784
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05919597
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00381387
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26674062
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26517441
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25783477
12* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.24523991
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.23575707
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22984058
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.19958504
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.16667589
17SCL_19346495_ChIP-Seq_HPC-7_Human2.10420423
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.02959553
19CLOCK_20551151_ChIP-Seq_293T_Human2.00268859
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98909069
21P300_27058665_Chip-Seq_ZR-75-30cells_Human1.95861518
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.93704168
23TP53_22127205_ChIP-Seq_IMR90_Human1.90736206
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.87022213
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86309966
26* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83478840
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.79297756
28* BRD4_25478319_ChIP-Seq_HGPS_Human1.77387750
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75527267
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75312873
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69813612
32CJUN_26792858_Chip-Seq_BT549_Human1.67979624
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.65387484
34* GATA2_21666600_ChIP-Seq_HMVEC_Human1.64176552
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63561438
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63339371
37AR_21909140_ChIP-Seq_LNCAP_Human1.60975923
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60057536
39MYC_22102868_ChIP-Seq_BL_Human1.57677498
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56585436
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56038689
42SMC1_22415368_ChIP-Seq_MEFs_Mouse1.55999581
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55772845
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53568787
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53568787
46* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.52261478
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.51818474
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50339061
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49083091
50* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48980051
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47500896
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46712294
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.46178376
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45459435
55* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44588928
56RACK7_27058665_Chip-Seq_MCF-7_Human1.44294936
57ELK1_19687146_ChIP-ChIP_HELA_Human1.44072382
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43794654
59ZNF263_19887448_ChIP-Seq_K562_Human1.42926065
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42638125
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42021276
62* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40942351
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.40227651
64ATF3_27146783_Chip-Seq_COLON_Human1.40075569
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.39606212
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39598187
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38654608
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38654608
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38654608
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.38640702
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36545003
72MYB_26560356_Chip-Seq_TH1_Human1.36290921
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.36259800
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.36259800
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34631546
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34152992
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31835319
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31774415
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31543974
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31369827
81TP53_23651856_ChIP-Seq_MEFs_Mouse1.29846491
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29028628
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28161371
84VDR_21846776_ChIP-Seq_THP-1_Human1.27437931
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.26428800
86* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25393759
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25313985
88LXR_22292898_ChIP-Seq_THP-1_Human1.25153540
89* RXR_22158963_ChIP-Seq_LIVER_Mouse1.24539534
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24107733
91* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23227760
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22812916
93TP53_16413492_ChIP-PET_HCT116_Human1.22786670
94* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22011679
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21785935
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21679259
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20432195
98* TP53_18474530_ChIP-ChIP_U2OS_Human1.19913073
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19127903
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18840634
101MYB_26560356_Chip-Seq_TH2_Human1.18305909
102* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17989185
103VDR_24763502_ChIP-Seq_THP-1_Human1.17044447
104* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16625296
105* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16050809
106SA1_22415368_ChIP-Seq_MEFs_Mouse1.15799304
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14898704
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14891446
109MAF_26560356_Chip-Seq_TH1_Human1.14756338
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14442234
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.12090787
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.08194621
113* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06158415
114RUNX_20019798_ChIP-Seq_JUKART_Human1.06152685
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05906518
116KDM2B_26808549_Chip-Seq_K562_Human1.05730840
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04220145
118* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03882211
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03842126
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03386906
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03253210
122* FOXA2_19822575_ChIP-Seq_HepG2_Human1.01628119
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01394127
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01320056
125STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01153657
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00680602
127SPI1_23547873_ChIP-Seq_NB4_Human1.00420551
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00222765
129* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.00156996
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00049915
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99442747
132LXR_22158963_ChIP-Seq_LIVER_Mouse0.99323057
133TCF7_22412390_ChIP-Seq_EML_Mouse0.99094245
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98989724
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98893244
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98815952
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98370897
138MYC_18555785_ChIP-Seq_MESCs_Mouse0.97653886
139VDR_24787735_ChIP-Seq_THP-1_Human0.97485462
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96642211
141* SOX2_20726797_ChIP-Seq_SW620_Human0.96080233
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93637643
143* FOXO3_23340844_ChIP-Seq_DLD1_Human0.93330715
144EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93329356
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91847521
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.91184943
147ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90778644
148UTX_26944678_Chip-Seq_JUKART_Human0.87301629
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85554968
150JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85013942
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84559686
152GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83437156
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83335521
154* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83163027
155* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83163027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.47186280
2MP0005503_abnormal_tendon_morphology4.38207780
3MP0005275_abnormal_skin_tensile3.14004678
4MP0006054_spinal_hemorrhage3.12966943
5MP0003279_aneurysm2.96060034
6MP0003950_abnormal_plasma_membrane2.93537459
7MP0010368_abnormal_lymphatic_system2.79263529
8MP0003705_abnormal_hypodermis_morpholog2.63721684
9MP0004272_abnormal_basement_membrane2.52329240
10MP0001879_abnormal_lymphatic_vessel2.20331190
11MP0001958_emphysema2.01311342
12MP0005508_abnormal_skeleton_morphology1.89922935
13MP0005023_abnormal_wound_healing1.89441955
14MP0010030_abnormal_orbit_morphology1.85436779
15MP0003566_abnormal_cell_adhesion1.69653177
16MP0009384_cardiac_valve_regurgitation1.63845842
17MP0000751_myopathy1.63079309
18MP0002060_abnormal_skin_morphology1.62496408
19MP0002396_abnormal_hematopoietic_system1.61896596
20MP0009053_abnormal_anal_canal1.60082410
21MP0000767_abnormal_smooth_muscle1.59072192
22MP0009780_abnormal_chondrocyte_physiolo1.57345752
23MP0000534_abnormal_ureter_morphology1.51740952
24MP0003567_abnormal_fetal_cardiomyocyte1.50545590
25MP0000013_abnormal_adipose_tissue1.50042947
26MP0001299_abnormal_eye_distance/1.42961130
27MP0004808_abnormal_hematopoietic_stem1.41261798
28MP0002933_joint_inflammation1.34385527
29MP0009697_abnormal_copulation1.32656399
30MP0005390_skeleton_phenotype1.29315564
31MP0003724_increased_susceptibility_to1.28583497
32MP0001348_abnormal_lacrimal_gland1.26479422
33MP0004858_abnormal_nervous_system1.26403781
34MP0001542_abnormal_bone_strength1.22286502
35MP0003191_abnormal_cellular_cholesterol1.20184679
36MP0005076_abnormal_cell_differentiation1.19606516
37MP0003091_abnormal_cell_migration1.19598406
38MP0005171_absent_coat_pigmentation1.18398340
39MP0003943_abnormal_hepatobiliary_system1.17596254
40MP0001243_abnormal_dermal_layer1.15700267
41MP0002108_abnormal_muscle_morphology1.15618028
42MP0002877_abnormal_melanocyte_morpholog1.15561224
43MP0008007_abnormal_cellular_replicative1.14571238
44MP0005360_urolithiasis1.13806728
45MP0009840_abnormal_foam_cell1.13133656
46MP0002168_other_aberrant_phenotype1.12715909
47MP0000003_abnormal_adipose_tissue1.12544368
48MP0009250_abnormal_appendicular_skeleto1.11932649
49MP0002932_abnormal_joint_morphology1.11498855
50MP0005257_abnormal_intraocular_pressure1.10838071
51MP0002282_abnormal_trachea_morphology1.10218309
52MP0004233_abnormal_muscle_weight1.10180520
53MP0005595_abnormal_vascular_smooth1.09970963
54MP0003942_abnormal_urinary_system1.09763051
55MP0003828_pulmonary_edema1.09692515
56MP0001915_intracranial_hemorrhage1.09680286
57MP0010352_gastrointestinal_tract_polyps1.08013291
58MP0004264_abnormal_extraembryonic_tissu1.07478864
59MP0003385_abnormal_body_wall1.05975425
60MP0001849_ear_inflammation1.05252689
61MP0002295_abnormal_pulmonary_circulatio1.03885906
62MP0002166_altered_tumor_susceptibility1.03432324
63MP0005397_hematopoietic_system_phenotyp1.01321293
64MP0001545_abnormal_hematopoietic_system1.01321293
65MP0005197_abnormal_uvea_morphology1.00191036
66MP0003252_abnormal_bile_duct1.00078773
67MP0003300_gastrointestinal_ulcer0.99902907
68MP0000163_abnormal_cartilage_morphology0.99898774
69MP0005409_darkened_coat_color0.99644501
70MP0000762_abnormal_tongue_morphology0.99213904
71MP0000343_altered_response_to0.94415054
72MP0000759_abnormal_skeletal_muscle0.93871345
73MP0002089_abnormal_postnatal_growth/wei0.93685257
74MP0002128_abnormal_blood_circulation0.92847662
75MP0000749_muscle_degeneration0.92378265
76MP0002113_abnormal_skeleton_development0.91174362
77MP0002115_abnormal_skeleton_extremities0.91093562
78MP0004134_abnormal_chest_morphology0.89182781
79MP0002938_white_spotting0.88073227
80MP0002925_abnormal_cardiovascular_devel0.87401297
81MP0003941_abnormal_skin_development0.87168860
82MP0002249_abnormal_larynx_morphology0.86570705
83MP0001533_abnormal_skeleton_physiology0.84886047
84MP0001835_abnormal_antigen_presentation0.83430713
85MP0001614_abnormal_blood_vessel0.83364415
86MP0005623_abnormal_meninges_morphology0.83150837
87MP0003115_abnormal_respiratory_system0.80470306
88MP0005058_abnormal_lysosome_morphology0.79835927
89MP0000428_abnormal_craniofacial_morphol0.79732423
90MP0001175_abnormal_lung_morphology0.79653479
91MP0009278_abnormal_bone_marrow0.79414593
92MP0002006_tumorigenesis0.78402477
93MP0000432_abnormal_head_morphology0.78207563
94MP0002998_abnormal_bone_remodeling0.78034628
95MP0005408_hypopigmentation0.77917345
96MP0003448_altered_tumor_morphology0.77677422
97MP0000566_synostosis0.77486588
98MP0004883_abnormal_blood_vessel0.76844499
99MP0005084_abnormal_gallbladder_morpholo0.75519039
100MP0000049_abnormal_middle_ear0.75494854
101MP0003795_abnormal_bone_structure0.74127825
102MP0002109_abnormal_limb_morphology0.73135050
103MP0000733_abnormal_muscle_development0.72768843
104MP0009333_abnormal_splenocyte_physiolog0.72653558
105MP0003984_embryonic_growth_retardation0.71598895
106MP0005164_abnormal_response_to0.71090238
107MP0003755_abnormal_palate_morphology0.71082473
108MP0002088_abnormal_embryonic_growth/wei0.70417520
109MP0005621_abnormal_cell_physiology0.70141180
110MP0002086_abnormal_extraembryonic_tissu0.69912074
111MP0001293_anophthalmia0.69171507
112MP0004197_abnormal_fetal_growth/weight/0.68557351
113MP0002928_abnormal_bile_duct0.67948690
114MP0003283_abnormal_digestive_organ0.67678141
115MP0000249_abnormal_blood_vessel0.67196532
116MP0005367_renal/urinary_system_phenotyp0.66732157
117MP0000516_abnormal_urinary_system0.66732157
118MP0003868_abnormal_feces_composition0.66628294
119MP0005193_abnormal_anterior_eye0.66484305
120MP0010307_abnormal_tumor_latency0.65066824
121MP0002114_abnormal_axial_skeleton0.65014189
122MP0000490_abnormal_crypts_of0.64893872
123MP0002896_abnormal_bone_mineralization0.64827344
124MP0003935_abnormal_craniofacial_develop0.64604927
125MP0006138_congestive_heart_failure0.64560656
126MP0000858_altered_metastatic_potential0.64136215
127MP0000372_irregular_coat_pigmentation0.63819842
128MP0003436_decreased_susceptibility_to0.63812136
129MP0004087_abnormal_muscle_fiber0.62679784
130MP0005165_increased_susceptibility_to0.62468611
131MP0003077_abnormal_cell_cycle0.62106730
132MP0002009_preneoplasia0.62053665
133MP0010386_abnormal_urinary_bladder0.61976460
134MP0001672_abnormal_embryogenesis/_devel0.61551927
135MP0001661_extended_life_span0.59601105
136MP0002116_abnormal_craniofacial_bone0.56968337
137MP0000462_abnormal_digestive_system0.56652901
138MP0002133_abnormal_respiratory_system0.55915842
139MP0005388_respiratory_system_phenotype0.55915842
140MP0005451_abnormal_body_composition0.55596148
141MP0002092_abnormal_eye_morphology0.55398476
142MP0001270_distended_abdomen0.54385814

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.46003087
2Premature rupture of membranes (HP:0001788)5.51434909
3Syringomyelia (HP:0003396)3.76609732
4Spinal cord lesions (HP:0100561)3.76609732
5Aortic dissection (HP:0002647)3.53875076
6Aortic aneurysm (HP:0004942)3.51497262
7Type 1 muscle fiber predominance (HP:0003803)3.42922079
8Soft skin (HP:0000977)3.39998568
9Vertebral compression fractures (HP:0002953)3.25336538
10Biconcave vertebral bodies (HP:0004586)3.21049879
11Cervical subluxation (HP:0003308)3.11341538
12Shallow orbits (HP:0000586)3.00814925
13Slender build (HP:0001533)2.96334590
14Blue sclerae (HP:0000592)2.86980699
15Broad metatarsal (HP:0001783)2.84504167
16Spondylolisthesis (HP:0003302)2.77484086
17Dilatation of the ascending aorta (HP:0005111)2.77276393
18Cerebral aneurysm (HP:0004944)2.73344303
19Increased connective tissue (HP:0009025)2.65023266
20Wormian bones (HP:0002645)2.64384480
21Mitral stenosis (HP:0001718)2.59876961
22Nonimmune hydrops fetalis (HP:0001790)2.59476780
23Ankle contracture (HP:0006466)2.58964350
24Increased variability in muscle fiber diameter (HP:0003557)2.56354728
25Ulnar bowing (HP:0003031)2.56291252
26Mildly elevated creatine phosphokinase (HP:0008180)2.56276149
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.55675550
28Osteolytic defects of the hand bones (HP:0009699)2.55675550
29Peritonitis (HP:0002586)2.54482421
30Short nail (HP:0001799)2.53775587
31Bladder diverticulum (HP:0000015)2.48827234
32Selective tooth agenesis (HP:0001592)2.45863561
33Atrophic scars (HP:0001075)2.45341226
34Asymmetry of the thorax (HP:0001555)2.43170071
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42079981
36Short 4th metacarpal (HP:0010044)2.42079981
37Decreased skull ossification (HP:0004331)2.36750548
38Abnormality of carpal bone ossification (HP:0006257)2.35449599
39Abnormal delivery (HP:0001787)2.34862906
40Neonatal short-limb short stature (HP:0008921)2.33385374
41Mitral valve prolapse (HP:0001634)2.32343884
42Fragile skin (HP:0001030)2.29675918
43Spinal rigidity (HP:0003306)2.27936911
44Abnormal ossification of hand bones (HP:0005921)2.25841211
45Abnormality of skeletal muscle fiber size (HP:0012084)2.22989588
46Abnormality of dentin (HP:0010299)2.18826506
47Pulmonary artery stenosis (HP:0004415)2.18223862
48Abnormality of skull ossification (HP:0002703)2.17358299
49Vascular tortuosity (HP:0004948)2.14285585
50Myocardial infarction (HP:0001658)2.12459494
51Abnormality of the acetabulum (HP:0003170)2.09186020
52Hypoventilation (HP:0002791)2.08090441
53Generalized amyotrophy (HP:0003700)2.05637488
54Long eyelashes (HP:0000527)2.03314677
55Coronal craniosynostosis (HP:0004440)2.03290270
56Achilles tendon contracture (HP:0001771)2.03096364
57Round ear (HP:0100830)2.01383706
58Breech presentation (HP:0001623)2.00964387
59Mitral regurgitation (HP:0001653)2.00079227
60Genu recurvatum (HP:0002816)1.98323244
61Renal duplication (HP:0000075)1.97600686
62Cupped ribs (HP:0000887)1.97331021
63Ovoid vertebral bodies (HP:0003300)1.96347104
64Aortic valve stenosis (HP:0001650)1.95821430
65Mesomelia (HP:0003027)1.94441314
66Distal upper limb amyotrophy (HP:0007149)1.94244957
67Upper limb amyotrophy (HP:0009129)1.94244957
68Abnormality of the distal phalanges of the toes (HP:0010182)1.94221182
69Abnormality of the peritoneum (HP:0002585)1.92688869
70Hematochezia (HP:0002573)1.92149606
71Wide anterior fontanel (HP:0000260)1.91984772
72Absent frontal sinuses (HP:0002688)1.91471136
73Abnormality of the Achilles tendon (HP:0005109)1.90953502
74Ectopia lentis (HP:0001083)1.89500561
75Delayed cranial suture closure (HP:0000270)1.89356321
76Thin bony cortex (HP:0002753)1.86570230
77Elbow flexion contracture (HP:0002987)1.86388564
78Inguinal hernia (HP:0000023)1.85879135
79Follicular hyperkeratosis (HP:0007502)1.85501041
80Deep philtrum (HP:0002002)1.84122242
81Protruding ear (HP:0000411)1.84113090
82Reduced subcutaneous adipose tissue (HP:0003758)1.82055020
83Alopecia of scalp (HP:0002293)1.81924136
84Cardiovascular calcification (HP:0011915)1.80994221
85Entropion (HP:0000621)1.80817558
86Joint laxity (HP:0001388)1.80643974
87Mild short stature (HP:0003502)1.80373434
88Cellulitis (HP:0100658)1.79352776
89Abnormal hand bone ossification (HP:0010660)1.79094714
90Joint stiffness (HP:0001387)1.78279954
91Bowing of the arm (HP:0006488)1.77270409
92Bowed forearm bones (HP:0003956)1.77270409
93Camptodactyly of toe (HP:0001836)1.76137066
94Limb-girdle muscle weakness (HP:0003325)1.76026858
95Long toe (HP:0010511)1.75808527
96Flared iliac wings (HP:0002869)1.74780295
97Distal lower limb muscle weakness (HP:0009053)1.74716261
98Distal lower limb amyotrophy (HP:0008944)1.73755839
99Flat acetabular roof (HP:0003180)1.73652552
100Abnormality of the 4th metacarpal (HP:0010012)1.73196244
101Broad long bones (HP:0005622)1.72513138
102Wrist flexion contracture (HP:0001239)1.71496172
103Overgrowth (HP:0001548)1.71442751
104B lymphocytopenia (HP:0010976)1.70755204
105Abnormality of B cell number (HP:0010975)1.70755204
106Platyspondyly (HP:0000926)1.70424772
107Dislocated radial head (HP:0003083)1.70166588
108Autoimmune thrombocytopenia (HP:0001973)1.69890101
109Mesangial abnormality (HP:0001966)1.68912521
110Deep venous thrombosis (HP:0002625)1.67710011
111Hyperacusis (HP:0010780)1.67518983
112Aortic regurgitation (HP:0001659)1.66577011
113Aneurysm (HP:0002617)1.65943638
114Bowel diverticulosis (HP:0005222)1.62176528
115Degeneration of anterior horn cells (HP:0002398)1.60205358
116Abnormality of the anterior horn cell (HP:0006802)1.60205358
117Abnormality of the radial head (HP:0003995)1.58665908
118Submucous cleft hard palate (HP:0000176)1.58468403
119Beaking of vertebral bodies (HP:0004568)1.58454660
120Osteoarthritis (HP:0002758)1.52814659
121Arterial tortuosity (HP:0005116)1.52793488
122Reduced antithrombin III activity (HP:0001976)1.52428890
123Abnormality of the phalanges of the hallux (HP:0010057)1.52007275
124Hyperextensible skin (HP:0000974)1.51481779
125Delayed closure of the anterior fontanelle (HP:0001476)1.51340800
126Broad phalanx (HP:0006009)1.50856123
127Subacute progressive viral hepatitis (HP:0006572)1.50061690
128Broad face (HP:0000283)1.49043730
129Short 5th finger (HP:0009237)1.48443838
130Coxa vara (HP:0002812)1.48282681
131Natal tooth (HP:0000695)1.48057134
132Flexion contracture of toe (HP:0005830)1.47144576
133Joint contractures involving the joints of the feet (HP:0100492)1.47144576
134Short middle phalanx of the 5th finger (HP:0004220)1.47011907
135Knee flexion contracture (HP:0006380)1.46903403
136Disproportionate tall stature (HP:0001519)1.46840886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.80664802
2MYLK3.26773434
3PTK22.84142160
4DDR22.57518595
5ICK2.41411967
6TGFBR22.40781839
7LATS12.40547489
8ZAK2.20282404
9TGFBR12.16659057
10NEK92.09984999
11TESK11.97483899
12NTRK11.96696378
13RIPK11.94329174
14NUAK11.93198809
15TRPM71.91856203
16SIK11.88866255
17LIMK11.86739779
18PIM21.84746746
19KDR1.80034010
20MET1.79871853
21KIT1.76759233
22EPHB21.76551749
23MOS1.75251436
24STK31.70830062
25NME21.64270729
26MAP3K141.61461356
27ERBB31.56508236
28STK381.55453692
29EPHA21.49339750
30RPS6KA41.47403000
31PIM11.43648067
32ERBB41.43313660
33PRPF4B1.42223091
34BRSK21.38954713
35PDGFRB1.37104470
36MAP2K31.34851598
37WEE11.31413076
38ACVR1B1.30544239
39CDK121.29443502
40SMG11.29125806
41MKNK11.28344464
42STK101.26401941
43FLT31.25545243
44CDC42BPA1.23086734
45CHUK1.22830028
46IRAK41.20889326
47TEC1.18028470
48PIK3CG1.17796851
49CSF1R1.16892572
50PDGFRA1.16684612
51JAK31.15242329
52TIE11.15195192
53TYK21.15004943
54EPHB11.14533854
55SIK31.14286611
56CDK71.13767484
57SCYL21.11385507
58LATS21.10229237
59MST1R1.09977302
60CDK81.06598647
61CDK61.06379109
62EIF2AK21.05611703
63EPHA31.04751584
64NLK1.02980050
65IKBKB1.02138410
66MAP4K11.00171020
67MAP3K30.98322906
68FRK0.95969836
69PAK20.95132354
70EEF2K0.94498885
71STK240.91830148
72LMTK20.89976401
73FGFR30.88502576
74DMPK0.87806673
75TBK10.87694503
76RPS6KA20.84801965
77TTN0.84325502
78BTK0.84120270
79IKBKE0.82108705
80STK38L0.81426832
81ROCK20.80137618
82STK40.79445862
83PRKG20.79172137
84PLK40.78075283
85LRRK20.77870071
86EIF2AK30.77237535
87YES10.77116388
88TAOK20.76885402
89ABL20.75495709
90PAK60.75360157
91MAP3K100.72432704
92WNK10.71296602
93PTK2B0.70970418
94MKNK20.70947241
95ROCK10.68904533
96EIF2AK10.66378029
97BMX0.66078664
98JAK10.65609852
99MAP3K80.64721119
100IRAK30.64328122
101MAPK70.63845815
102BMPR1B0.62763687
103PIK3CA0.62459820
104BRD40.62357673
105ILK0.61938233
106TESK20.60257644
107ZAP700.60107545
108MTOR0.59953788
109PAK40.59559133
110KSR20.58860031
111GSK3A0.58099117
112MELK0.57510056
113ATR0.57502721
114CSK0.56309849
115HCK0.55869014
116MAPK110.55809499
117MAP3K60.55343967
118NEK20.53574893
119ARAF0.51718864
120PLK20.50504177
121PTK60.50195291
122PLK30.50023681
123PAK10.49850948
124FGFR40.49441827
125AKT30.48583338
126CLK10.46669056
127RPS6KA60.46246402
128RPS6KL10.46161414
129RPS6KC10.46161414
130TRIB30.45848290
131ABL10.45791609
132PKN20.45171953
133CDK90.44897274
134CDC70.44014539
135ERBB20.43275145
136CDK40.42579347
137BRSK10.42182504
138PLK10.41835415
139PRKD20.41734384
140MAP2K10.41612580
141MAPKAPK20.40950320
142PDPK10.39312860
143FGFR10.38460695
144DAPK30.37429378
145MAP3K70.36894404
146RET0.35854751
147MUSK0.35719099
148DYRK1B0.35493058
149MAP3K130.35276952
150MAPKAPK30.35247232
151ADRBK10.32219549
152PRKD30.29992874
153CDK150.29513926
154PRKD10.28264391
155SRC0.27760658

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.49734538
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24379374
3ECM-receptor interaction_Homo sapiens_hsa045122.11833822
4DNA replication_Homo sapiens_hsa030301.89984635
5Base excision repair_Homo sapiens_hsa034101.81099624
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79425393
7Malaria_Homo sapiens_hsa051441.76576614
8Regulation of actin cytoskeleton_Homo sapiens_hsa048101.76398469
9Small cell lung cancer_Homo sapiens_hsa052221.66556227
10Dilated cardiomyopathy_Homo sapiens_hsa054141.63376909
11TGF-beta signaling pathway_Homo sapiens_hsa043501.53663645
12Complement and coagulation cascades_Homo sapiens_hsa046101.53220156
13Adherens junction_Homo sapiens_hsa045201.53035160
14Focal adhesion_Homo sapiens_hsa045101.50547779
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.48502341
16Cell cycle_Homo sapiens_hsa041101.46833599
17MicroRNAs in cancer_Homo sapiens_hsa052061.43158897
18One carbon pool by folate_Homo sapiens_hsa006701.41294968
19p53 signaling pathway_Homo sapiens_hsa041151.35391295
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35217778
21Herpes simplex infection_Homo sapiens_hsa051681.34340393
22Leishmaniasis_Homo sapiens_hsa051401.33346326
23Melanoma_Homo sapiens_hsa052181.31880764
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.31163980
25Proteoglycans in cancer_Homo sapiens_hsa052051.25687096
26Prion diseases_Homo sapiens_hsa050201.24856347
27Staphylococcus aureus infection_Homo sapiens_hsa051501.20376744
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19994660
29Homologous recombination_Homo sapiens_hsa034401.18261531
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18071903
31Mismatch repair_Homo sapiens_hsa034301.17168679
32Prostate cancer_Homo sapiens_hsa052151.15363083
33Protein digestion and absorption_Homo sapiens_hsa049741.14392780
34Viral myocarditis_Homo sapiens_hsa054161.13720367
35Measles_Homo sapiens_hsa051621.13161846
36Lysine degradation_Homo sapiens_hsa003101.12890454
37Notch signaling pathway_Homo sapiens_hsa043301.12813600
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11926328
39Hepatitis B_Homo sapiens_hsa051611.11432883
40Basal cell carcinoma_Homo sapiens_hsa052171.10949912
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.10230286
42Protein export_Homo sapiens_hsa030601.09570237
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08755133
44Thyroid cancer_Homo sapiens_hsa052161.07761111
45Chronic myeloid leukemia_Homo sapiens_hsa052201.05564990
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05504733
47N-Glycan biosynthesis_Homo sapiens_hsa005101.04911222
48Glioma_Homo sapiens_hsa052141.04263514
49HTLV-I infection_Homo sapiens_hsa051661.03782988
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03115390
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02997725
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01928749
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.01617796
54Toxoplasmosis_Homo sapiens_hsa051451.00339652
55Renal cell carcinoma_Homo sapiens_hsa052110.98946794
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98193946
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97879297
58Hedgehog signaling pathway_Homo sapiens_hsa043400.96584397
59Antigen processing and presentation_Homo sapiens_hsa046120.95948309
60Non-homologous end-joining_Homo sapiens_hsa034500.95081994
61Legionellosis_Homo sapiens_hsa051340.94680237
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.94319820
63Non-small cell lung cancer_Homo sapiens_hsa052230.93169914
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.93137142
65Apoptosis_Homo sapiens_hsa042100.92033107
66Primary immunodeficiency_Homo sapiens_hsa053400.91961957
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91539837
68TNF signaling pathway_Homo sapiens_hsa046680.90109864
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89869698
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89809502
71Gap junction_Homo sapiens_hsa045400.89624069
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88475815
73Galactose metabolism_Homo sapiens_hsa000520.88262914
74Fanconi anemia pathway_Homo sapiens_hsa034600.87989571
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87657255
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86598349
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.85963053
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.85505869
79Endometrial cancer_Homo sapiens_hsa052130.85391122
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84629913
81Hippo signaling pathway_Homo sapiens_hsa043900.84531827
82Shigellosis_Homo sapiens_hsa051310.84365628
83Hematopoietic cell lineage_Homo sapiens_hsa046400.83577597
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83171819
85Endocytosis_Homo sapiens_hsa041440.82689217
86Pathways in cancer_Homo sapiens_hsa052000.82012006
87Bladder cancer_Homo sapiens_hsa052190.81387402
88Starch and sucrose metabolism_Homo sapiens_hsa005000.79300887
89Rap1 signaling pathway_Homo sapiens_hsa040150.78689931
90Melanogenesis_Homo sapiens_hsa049160.78438571
91Amoebiasis_Homo sapiens_hsa051460.77504707
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77351832
93Influenza A_Homo sapiens_hsa051640.76809790
94Pancreatic cancer_Homo sapiens_hsa052120.76065590
95Axon guidance_Homo sapiens_hsa043600.75808135
96Vibrio cholerae infection_Homo sapiens_hsa051100.75743500
97Wnt signaling pathway_Homo sapiens_hsa043100.74615033
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.74151622
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73629830
100Caffeine metabolism_Homo sapiens_hsa002320.73277830
101Thyroid hormone synthesis_Homo sapiens_hsa049180.72555258
102Platelet activation_Homo sapiens_hsa046110.71471568
103Viral carcinogenesis_Homo sapiens_hsa052030.71324142
104Pertussis_Homo sapiens_hsa051330.70669571
105Spliceosome_Homo sapiens_hsa030400.69378829
106B cell receptor signaling pathway_Homo sapiens_hsa046620.68141227
107Tight junction_Homo sapiens_hsa045300.67566672
108Osteoclast differentiation_Homo sapiens_hsa043800.67115974
109Renin-angiotensin system_Homo sapiens_hsa046140.66816731
110Retinol metabolism_Homo sapiens_hsa008300.65427774
111Colorectal cancer_Homo sapiens_hsa052100.65311923
112Acute myeloid leukemia_Homo sapiens_hsa052210.65084927
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64608430
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64568631
115Pentose phosphate pathway_Homo sapiens_hsa000300.63847744
116mTOR signaling pathway_Homo sapiens_hsa041500.63622872
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.62852470
118Pyrimidine metabolism_Homo sapiens_hsa002400.62622979
119Nucleotide excision repair_Homo sapiens_hsa034200.62398389
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60774397
121Arachidonic acid metabolism_Homo sapiens_hsa005900.60419958
122Other glycan degradation_Homo sapiens_hsa005110.58868251
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58725576
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.57887960
125Estrogen signaling pathway_Homo sapiens_hsa049150.57237098
126RNA degradation_Homo sapiens_hsa030180.56604836
127RNA transport_Homo sapiens_hsa030130.54722146
128VEGF signaling pathway_Homo sapiens_hsa043700.54699457
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53084999
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52650844
131GnRH signaling pathway_Homo sapiens_hsa049120.52250580
132ErbB signaling pathway_Homo sapiens_hsa040120.52130631
133Chemical carcinogenesis_Homo sapiens_hsa052040.51955379
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51556204
135AMPK signaling pathway_Homo sapiens_hsa041520.49354197
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48439685
137Ras signaling pathway_Homo sapiens_hsa040140.48146130
138Lysosome_Homo sapiens_hsa041420.46691103
139Salmonella infection_Homo sapiens_hsa051320.45405424
140Insulin signaling pathway_Homo sapiens_hsa049100.45277062
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44953491
142Insulin resistance_Homo sapiens_hsa049310.44689250
143FoxO signaling pathway_Homo sapiens_hsa040680.43609487
144MAPK signaling pathway_Homo sapiens_hsa040100.42341949
145Sphingolipid metabolism_Homo sapiens_hsa006000.41173173
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.40932837
147Vitamin B6 metabolism_Homo sapiens_hsa007500.39208455
148Biosynthesis of amino acids_Homo sapiens_hsa012300.38831778
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.37052535
150Inositol phosphate metabolism_Homo sapiens_hsa005620.36634463

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