TRAJ32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.39212076
2DNA deamination (GO:0045006)9.25297804
3pyrimidine ribonucleoside catabolic process (GO:0046133)9.10565419
4T cell migration (GO:0072678)6.09929273
5monocyte chemotaxis (GO:0002548)6.01318604
6Arp2/3 complex-mediated actin nucleation (GO:0034314)5.98931725
7positive thymic T cell selection (GO:0045059)5.97011274
8regulation of B cell receptor signaling pathway (GO:0050855)5.69770608
9negative regulation of B cell proliferation (GO:0030889)5.65788953
10positive regulation of B cell differentiation (GO:0045579)5.42343522
11regulation of T cell tolerance induction (GO:0002664)5.40136356
12positive T cell selection (GO:0043368)5.32572403
13positive regulation of tolerance induction (GO:0002645)5.28254295
14actin nucleation (GO:0045010)5.10103795
15negative T cell selection (GO:0043383)5.02620198
16negative thymic T cell selection (GO:0045060)4.97442199
17regulation of B cell differentiation (GO:0045577)4.78131241
18thymic T cell selection (GO:0045061)4.54116163
19regulation of tolerance induction (GO:0002643)4.50781757
20pyrimidine nucleoside catabolic process (GO:0046135)4.45927835
21regulation of alpha-beta T cell proliferation (GO:0046640)4.45673844
22regulation of regulatory T cell differentiation (GO:0045589)4.44397530
23regulation of activation of Janus kinase activity (GO:0010533)4.42732469
24positive regulation of gamma-delta T cell activation (GO:0046645)4.42576191
25negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.41118606
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40982416
27negative regulation of viral genome replication (GO:0045071)4.25758281
28negative regulation by host of viral transcription (GO:0043922)4.23326115
29negative regulation of B cell activation (GO:0050869)4.22001815
30positive regulation of calcium-mediated signaling (GO:0050850)4.20022868
31dendritic cell chemotaxis (GO:0002407)4.17238258
32intestinal epithelial cell development (GO:0060576)4.16779014
33regulation of lymphocyte chemotaxis (GO:1901623)4.14775601
34cellular response to interleukin-15 (GO:0071350)4.13963103
35regulation of T cell chemotaxis (GO:0010819)4.07711129
36positive regulation of T cell chemotaxis (GO:0010820)4.07711129
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.07327128
38eosinophil chemotaxis (GO:0048245)4.05038423
39mast cell activation (GO:0045576)4.05036417
40positive regulation of natural killer cell mediated immunity (GO:0002717)4.01518904
41regulation of chronic inflammatory response (GO:0002676)3.97959236
42adaptation of signaling pathway (GO:0023058)3.96211970
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.92535042
44T cell mediated immunity (GO:0002456)3.91934788
45T cell selection (GO:0045058)3.91915785
46positive regulation of defense response to virus by host (GO:0002230)3.86381643
47negative regulation of T cell receptor signaling pathway (GO:0050860)3.86149398
48T cell costimulation (GO:0031295)3.82298628
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78965140
50negative regulation of cell killing (GO:0031342)3.78965140
51lymphocyte costimulation (GO:0031294)3.77555947
52T cell receptor signaling pathway (GO:0050852)3.77035295
53negative regulation of T cell apoptotic process (GO:0070233)3.71855022
54positive regulation of monocyte chemotaxis (GO:0090026)3.71098399
55negative regulation of macroautophagy (GO:0016242)3.70852587
56macrophage chemotaxis (GO:0048246)3.69294999
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.66853502
58eosinophil migration (GO:0072677)3.66543528
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.59881617
60regulation of natural killer cell mediated immunity (GO:0002715)3.59881617
61interferon-gamma production (GO:0032609)3.58957087
62negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.54063863
63antigen receptor-mediated signaling pathway (GO:0050851)3.49978526
64antigen processing and presentation via MHC class Ib (GO:0002475)3.47544785
65mast cell activation involved in immune response (GO:0002279)3.44543698
66mast cell degranulation (GO:0043303)3.44543698
67response to interleukin-15 (GO:0070672)3.42688630
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41921907
69positive regulation of interleukin-4 production (GO:0032753)3.41145645
70regulation of chemokine-mediated signaling pathway (GO:0070099)3.40343407
71dendritic cell migration (GO:0036336)3.39751887
72regulation of interleukin-2 biosynthetic process (GO:0045076)3.37866692
73lymphocyte migration (GO:0072676)3.35843818
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30324271
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.29963043
76lymphocyte chemotaxis (GO:0048247)3.22423801
77positive regulation of lymphocyte migration (GO:2000403)3.22244803
78negative regulation of organelle assembly (GO:1902116)3.21693693
79regulation of viral genome replication (GO:0045069)3.20427208
80regulation of gamma-delta T cell activation (GO:0046643)3.17956317
81regulation of leukocyte mediated cytotoxicity (GO:0001910)3.15950443
82regulation of gamma-delta T cell differentiation (GO:0045586)3.14205751
83hepatocyte apoptotic process (GO:0097284)3.13614705
84positive regulation of interleukin-8 secretion (GO:2000484)3.12562630
85activated T cell proliferation (GO:0050798)3.11430558
86chemokine-mediated signaling pathway (GO:0070098)3.10550947
87leukocyte aggregation (GO:0070486)3.09989784
88regulation of defense response to virus by host (GO:0050691)3.07060368
89regulation of calcium-mediated signaling (GO:0050848)3.06410170
90positive regulation of granulocyte differentiation (GO:0030854)3.03172049
91regulation of macrophage chemotaxis (GO:0010758)3.02293535
92B cell receptor signaling pathway (GO:0050853)3.01124783
93positive regulation of cell killing (GO:0031343)2.98369710
94regulation of isotype switching to IgG isotypes (GO:0048302)2.96679435
95DNA demethylation (GO:0080111)2.89904888
96regulation of T cell receptor signaling pathway (GO:0050856)2.88429931
97regulation of cell killing (GO:0031341)2.82190767
98cytidine catabolic process (GO:0006216)10.3560994
99cytidine deamination (GO:0009972)10.3560994
100cytidine metabolic process (GO:0046087)10.3560994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.98396042
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.61588154
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.30198680
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.07740779
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.96675413
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.62595655
7ELF1_17652178_ChIP-ChIP_JURKAT_Human4.40161854
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.14644045
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.82889235
10RUNX_20019798_ChIP-Seq_JUKART_Human3.47869467
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34262818
12MYB_26560356_Chip-Seq_TH2_Human3.24778660
13GATA1_22025678_ChIP-Seq_K562_Human2.81592879
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80160745
15GATA3_27048872_Chip-Seq_THYMUS_Human2.65386868
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.58310605
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31991244
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27199360
19MYB_26560356_Chip-Seq_TH1_Human2.23030615
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.16028741
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07886791
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.03603750
23GATA3_26560356_Chip-Seq_TH2_Human2.02983778
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.94086818
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85912107
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75544788
27VDR_23849224_ChIP-Seq_CD4+_Human1.65467044
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64954452
29CIITA_25753668_ChIP-Seq_RAJI_Human1.62199792
30UTX_26944678_Chip-Seq_JUKART_Human1.60687271
31SPI1_23547873_ChIP-Seq_NB4_Human1.59011078
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.58705002
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55478955
34MAF_26560356_Chip-Seq_TH1_Human1.52152630
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.50791513
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47754459
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47089596
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46616470
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43156081
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38658659
41TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.34094579
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32098779
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30656470
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.24111271
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21084071
46FOXP3_21729870_ChIP-Seq_TREG_Human1.19643698
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18684435
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.15469508
49MAF_26560356_Chip-Seq_TH2_Human1.14565678
50GATA3_26560356_Chip-Seq_TH1_Human1.13370815
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06573287
52ELK1_19687146_ChIP-ChIP_HELA_Human1.00472915
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97426220
54HTT_18923047_ChIP-ChIP_STHdh_Human0.97235454
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97074470
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95465665
57BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95083501
58TP53_16413492_ChIP-PET_HCT116_Human0.94830714
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92808023
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89651319
61ERG_20517297_ChIP-Seq_VCAP_Human0.89523419
62SPI1_23127762_ChIP-Seq_K562_Human0.89136773
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88334427
64GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87803144
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87067586
66PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86661000
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85430347
68EZH2_27294783_Chip-Seq_NPCs_Mouse0.84318940
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83945250
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83445210
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83074011
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82221966
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81593112
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81314279
75BCAT_22108803_ChIP-Seq_LS180_Human0.81287333
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80017822
77PRDM14_20953172_ChIP-Seq_ESCs_Human0.79623272
78TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77405223
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.76086298
80E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75451927
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.73934223
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73605761
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73353232
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72791222
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71808388
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.71348544
87RUNX1_22412390_ChIP-Seq_EML_Mouse0.71253906
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.69436111
89BCL6_27268052_Chip-Seq_Bcells_Human0.68702382
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67854472
91IRF1_19129219_ChIP-ChIP_H3396_Human0.67651014
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.67566348
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67403153
94SCL_19346495_ChIP-Seq_HPC-7_Human0.66673574
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66264443
96E2F7_22180533_ChIP-Seq_HELA_Human0.66106410
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65819906
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.64425558
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.64210151
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.63240576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.54196806
2MP0003763_abnormal_thymus_physiology4.29318220
3MP0003183_abnormal_peptide_metabolism3.17634280
4MP0009785_altered_susceptibility_to3.10622012
5MP0009333_abnormal_splenocyte_physiolog3.04645134
6MP0000372_irregular_coat_pigmentation3.00430470
7MP0001800_abnormal_humoral_immune2.97264342
8MP0001835_abnormal_antigen_presentation2.92569331
9MP0003011_delayed_dark_adaptation2.81541572
10MP0003045_fibrosis2.67494191
11MP0001188_hyperpigmentation2.59993761
12MP0002420_abnormal_adaptive_immunity2.58603735
13MP0005000_abnormal_immune_tolerance2.57507090
14MP0004381_abnormal_hair_follicle2.56198909
15MP0001819_abnormal_immune_cell2.52127176
16MP0002405_respiratory_system_inflammati2.50056379
17MP0002148_abnormal_hypersensitivity_rea2.46511256
18MP0002723_abnormal_immune_serum2.44884322
19MP0000716_abnormal_immune_system2.37352286
20MP0002398_abnormal_bone_marrow2.35572803
21MP0001873_stomach_inflammation2.35299839
22MP0005025_abnormal_response_to2.35190005
23MP0000685_abnormal_immune_system2.34881245
24MP0000703_abnormal_thymus_morphology2.26290150
25MP0001853_heart_inflammation2.25102864
26MP0002452_abnormal_antigen_presenting2.18443900
27MP0003866_abnormal_defecation2.02011608
28MP0005387_immune_system_phenotype1.89118786
29MP0001790_abnormal_immune_system1.89118786
30MP0002722_abnormal_immune_system1.81430036
31MP0002429_abnormal_blood_cell1.79097345
32MP0003448_altered_tumor_morphology1.71251058
33MP0000689_abnormal_spleen_morphology1.69648713
34MP0002419_abnormal_innate_immunity1.66405642
35MP0002006_tumorigenesis1.62815888
36MP0005310_abnormal_salivary_gland1.62067163
37MP0002166_altered_tumor_susceptibility1.61279760
38MP0003436_decreased_susceptibility_to1.59611479
39MP0010155_abnormal_intestine_physiology1.58546085
40MP0003806_abnormal_nucleotide_metabolis1.50333931
41MP0002163_abnormal_gland_morphology1.47199054
42MP0006082_CNS_inflammation1.42675978
43MP0005075_abnormal_melanosome_morpholog1.39459741
44MP0001845_abnormal_inflammatory_respons1.38762294
45MP0002019_abnormal_tumor_incidence1.34067727
46MP0002396_abnormal_hematopoietic_system1.30435018
47MP0001919_abnormal_reproductive_system1.30065345
48MP0005464_abnormal_platelet_physiology1.30034240
49MP0000569_abnormal_digit_pigmentation1.29192966
50MP0003724_increased_susceptibility_to1.25552332
51MP0003191_abnormal_cellular_cholesterol1.22980497
52MP0002933_joint_inflammation1.19401237
53MP0010307_abnormal_tumor_latency1.19303657
54MP0009763_increased_sensitivity_to1.08040005
55MP0004145_abnormal_muscle_electrophysio1.07582910
56MP0002877_abnormal_melanocyte_morpholog1.07385443
57MP0001984_abnormal_olfaction1.05067976
58MP0002138_abnormal_hepatobiliary_system1.03910833
59MP0009379_abnormal_foot_pigmentation1.02555542
60MP0003786_premature_aging0.99686575
61MP0004134_abnormal_chest_morphology0.99562861
62MP0008789_abnormal_olfactory_epithelium0.98713705
63MP0000858_altered_metastatic_potential0.96009409
64MP0008007_abnormal_cellular_replicative0.95628762
65MP0008873_increased_physiological_sensi0.95071261
66MP0008260_abnormal_autophagy0.87645063
67MP0005389_reproductive_system_phenotype0.83912935
68MP0000920_abnormal_myelination0.81244433
69MP0002168_other_aberrant_phenotype0.81069468
70MP0000490_abnormal_crypts_of0.80772732
71MP0005379_endocrine/exocrine_gland_phen0.80336076
72MP0001905_abnormal_dopamine_level0.79616836
73MP0005499_abnormal_olfactory_system0.78418471
74MP0005394_taste/olfaction_phenotype0.78418471
75MP0002638_abnormal_pupillary_reflex0.74350657
76MP0009765_abnormal_xenobiotic_induced0.73786479
77MP0005623_abnormal_meninges_morphology0.72567679
78MP0004947_skin_inflammation0.72451558
79MP0005408_hypopigmentation0.70784412
80MP0000465_gastrointestinal_hemorrhage0.70719093
81MP0001533_abnormal_skeleton_physiology0.66793992
82MP0002693_abnormal_pancreas_physiology0.66621354
83MP0001958_emphysema0.66466967
84MP0009643_abnormal_urine_homeostasis0.63820093
85MP0003567_abnormal_fetal_cardiomyocyte0.61303579
86MP0002277_abnormal_respiratory_mucosa0.60536055
87MP0008469_abnormal_protein_level0.59670653
88MP0000639_abnormal_adrenal_gland0.58705305
89MP0005360_urolithiasis0.58627826
90MP0005645_abnormal_hypothalamus_physiol0.56350088
91MP0006035_abnormal_mitochondrial_morpho0.55957487
92MP0001765_abnormal_ion_homeostasis0.55676516
93MP0006276_abnormal_autonomic_nervous0.54457153
94MP0000733_abnormal_muscle_development0.53301111
95MP0009840_abnormal_foam_cell0.52432808
96MP0001191_abnormal_skin_condition0.52320706
97MP0005166_decreased_susceptibility_to0.51766970
98MP0002136_abnormal_kidney_physiology0.51511310
99MP0000604_amyloidosis0.50692746
100MP0001186_pigmentation_phenotype0.49375739

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.08477570
2Abnormality of T cell number (HP:0011839)8.21171942
3Abnormality of T cells (HP:0002843)5.25954167
4Severe combined immunodeficiency (HP:0004430)4.59738957
5Autoimmune hemolytic anemia (HP:0001890)4.39060431
6Elevated erythrocyte sedimentation rate (HP:0003565)3.99665385
7IgG deficiency (HP:0004315)3.94858120
8Recurrent bronchitis (HP:0002837)3.93447088
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.91193887
10Dysautonomia (HP:0002459)3.89270661
11Chronic mucocutaneous candidiasis (HP:0002728)3.83912365
12Recurrent cutaneous fungal infections (HP:0011370)3.83912365
13Combined immunodeficiency (HP:0005387)3.79153799
14Thyroiditis (HP:0100646)3.69211962
15Hypoplasia of the thymus (HP:0000778)3.52541890
16Abnormality of the prostate (HP:0008775)3.50646587
17Agammaglobulinemia (HP:0004432)3.47950224
18Recurrent viral infections (HP:0004429)3.47888931
19Aplastic anemia (HP:0001915)3.28915406
203-Methylglutaconic aciduria (HP:0003535)3.28564342
21Chronic diarrhea (HP:0002028)3.25011007
22Meningitis (HP:0001287)3.24760971
23Hypoproteinemia (HP:0003075)3.19169030
24Panhypogammaglobulinemia (HP:0003139)3.17609441
25Obstructive lung disease (HP:0006536)3.14770747
26Chronic obstructive pulmonary disease (HP:0006510)3.14770747
27Menstrual irregularities (HP:0000858)3.10058553
28Encephalitis (HP:0002383)3.03910730
29Lymphopenia (HP:0001888)3.03329508
30Optic neuritis (HP:0100653)2.94859149
31Retrobulbar optic neuritis (HP:0100654)2.94859149
32Orthostatic hypotension (HP:0001278)2.91463719
33Abnormality of eosinophils (HP:0001879)2.84829764
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.84069757
35Chest pain (HP:0100749)2.79294923
36Myositis (HP:0100614)2.76688578
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74684704
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74684704
39Pulmonary infiltrates (HP:0002113)2.72597573
40Recurrent fungal infections (HP:0002841)2.68745380
41Gangrene (HP:0100758)2.68179540
42Ureteral stenosis (HP:0000071)2.66091223
43Vasculitis (HP:0002633)2.65002138
44Ureteral obstruction (HP:0006000)2.63615216
45Alveolar cell carcinoma (HP:0006519)2.62904231
46Pulmonary embolism (HP:0002204)2.62525073
47Abnormality of the pleura (HP:0002103)2.58688953
48Type I transferrin isoform profile (HP:0003642)2.56147862
49Hemoptysis (HP:0002105)2.55570050
50IgM deficiency (HP:0002850)2.55445233
51Anhidrosis (HP:0000970)2.54217248
52Leukocytosis (HP:0001974)2.49451294
53Recurrent skin infections (HP:0001581)2.47512315
54Orchitis (HP:0100796)2.46409822
55Abnormality of T cell physiology (HP:0011840)2.45703913
56Carpal bone hypoplasia (HP:0001498)2.44915119
57Recurrent bacterial skin infections (HP:0005406)2.39660664
58Neoplasm of the tracheobronchial system (HP:0100552)2.38754471
59Hypoalbuminemia (HP:0003073)2.35175036
60Abnormal albumin level (HP:0012116)2.35175036
61Genetic anticipation (HP:0003743)2.30932235
62Amyotrophic lateral sclerosis (HP:0007354)2.25449007
63Abnormality of fatty-acid metabolism (HP:0004359)2.25359050
64Purpura (HP:0000979)2.22049049
65Bronchitis (HP:0012387)2.21326973
66Recurrent otitis media (HP:0000403)2.20517361
67Joint swelling (HP:0001386)2.11278343
68Dicarboxylic aciduria (HP:0003215)2.08158203
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08158203
70Oral leukoplakia (HP:0002745)2.08142763
71Abnormality of male internal genitalia (HP:0000022)2.06800723
72Abnormal autonomic nervous system physiology (HP:0012332)2.06752486
73Recurrent abscess formation (HP:0002722)2.03169745
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03004949
75Keratoconjunctivitis sicca (HP:0001097)2.02280162
76Arthropathy (HP:0003040)2.02028436
77Spontaneous hematomas (HP:0007420)2.01134540
78Eosinophilia (HP:0001880)2.00147226
79Mediastinal lymphadenopathy (HP:0100721)1.98453777
80Increased IgM level (HP:0003496)1.97545972
81Abnormality of the pericardium (HP:0001697)1.95954573
82Pulmonary fibrosis (HP:0002206)1.94148739
83Polyneuropathy (HP:0001271)1.91346209
84Glomerulopathy (HP:0100820)1.89044665
85Poor speech (HP:0002465)1.87935569
86Bronchiectasis (HP:0002110)1.87725859
87Increased intramyocellular lipid droplets (HP:0012240)1.86370983
88Neoplasm of the heart (HP:0100544)1.84893712
89Keratoconjunctivitis (HP:0001096)1.84746838
90Lymphoma (HP:0002665)1.81046583
91Gaze-evoked nystagmus (HP:0000640)1.80427962
92Arterial thrombosis (HP:0004420)1.80318799
93Inflammation of the large intestine (HP:0002037)1.77727595
94Pustule (HP:0200039)1.77538710
95Hemiplegia (HP:0002301)1.77036824
96Reduced subcutaneous adipose tissue (HP:0003758)1.76482499
97Glucose intolerance (HP:0000833)1.75446275
98Self-mutilation (HP:0000742)1.75025652
99Abnormality of the columella (HP:0009929)1.73268244
100Abnormal mitochondria in muscle tissue (HP:0008316)1.73152423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.44707540
2SCYL25.01674368
3KDR4.43621787
4PIK3CG4.03034572
5MAP4K12.71025389
6FES2.62756289
7TESK22.53445432
8ITK2.41544196
9CAMKK22.37245303
10MST41.91685444
11TAOK31.87861924
12ZAP701.87664573
13MATK1.87044542
14NTRK11.86937752
15TNK21.73214647
16BLK1.66344941
17IKBKE1.60618900
18SYK1.60209578
19CSK1.57373457
20BTK1.57236510
21RIPK41.52439809
22LCK1.45835845
23BRSK21.43463018
24GRK61.41278050
25MAP3K91.36191194
26EIF2AK31.33995998
27ARAF1.27806478
28TYRO31.19841686
29MAP3K131.15760258
30LYN1.13339886
31CSF1R1.10269844
32PRKCQ1.08777838
33TBK10.99057391
34TESK10.98995848
35TEC0.98779925
36IKBKB0.97511286
37ADRBK20.93721930
38MAP3K120.91185308
39CAMKK10.86014286
40VRK10.85882758
41MAPKAPK30.83297768
42PIM10.82941527
43FRK0.80615193
44STK40.79531822
45CDK40.75468315
46HCK0.69161119
47NEK60.64189117
48FYN0.61516830
49TLK10.61026239
50MYLK0.60597229
51MARK30.60406400
52PIM20.59519326
53ERBB20.59144191
54JAK30.57328119
55AURKA0.56175967
56BMPR20.56005459
57STK110.55861780
58MAP2K60.55471589
59FGR0.53074047
60OBSCN0.51768894
61GRK50.51636185
62ATR0.50934274
63PDGFRB0.41806979
64FGFR10.40934842
65IGF1R0.39671596
66JAK20.36756045
67BUB10.35415525
68MAP3K110.35000202
69LRRK20.33757888
70TYK20.33466193
71STK240.32521194
72INSR0.32154441
73INSRR0.30277767
74LIMK10.29503310
75CAMK40.28591491
76RPS6KA50.27322941
77EGFR0.26890677
78PDK10.26289144
79DAPK30.25802701
80AURKB0.25742237
81ROCK10.25507440
82MAP3K20.25079510
83MAP3K140.24592714
84VRK20.24509745
85TIE10.23429764
86GRK70.23324731
87BRSK10.22654633
88FLT30.22281217
89PRKD10.22093618
90BCKDK0.21450454
91NUAK10.21368557
92PRKCB0.21122774
93MAPK110.20882241
94DYRK1A0.20718857
95GRK10.20711981
96MAPKAPK20.20677815
97CAMK2A0.19381383
98NLK0.19067540
99JAK10.18855714
100RAF10.18622574

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.76415045
2Graft-versus-host disease_Homo sapiens_hsa053323.82007458
3Autoimmune thyroid disease_Homo sapiens_hsa053203.38652988
4Proteasome_Homo sapiens_hsa030503.19373927
5T cell receptor signaling pathway_Homo sapiens_hsa046603.18963173
6Antigen processing and presentation_Homo sapiens_hsa046123.10154171
7Hematopoietic cell lineage_Homo sapiens_hsa046403.01474543
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.87084803
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.80910083
10Allograft rejection_Homo sapiens_hsa053302.55607755
11Measles_Homo sapiens_hsa051622.13811037
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11285967
13Type I diabetes mellitus_Homo sapiens_hsa049401.97742818
14Systemic lupus erythematosus_Homo sapiens_hsa053221.92627472
15Non-homologous end-joining_Homo sapiens_hsa034501.68189075
16Rheumatoid arthritis_Homo sapiens_hsa053231.65837172
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61802549
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60864470
19Oxidative phosphorylation_Homo sapiens_hsa001901.58570250
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57790070
21Chemokine signaling pathway_Homo sapiens_hsa040621.56866340
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.47904000
23Shigellosis_Homo sapiens_hsa051311.47357786
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40011959
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.38009064
26Regulation of autophagy_Homo sapiens_hsa041401.33976984
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32538735
28Viral myocarditis_Homo sapiens_hsa054161.28994717
29Parkinsons disease_Homo sapiens_hsa050121.25397631
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23287482
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22667922
32Non-small cell lung cancer_Homo sapiens_hsa052231.15240956
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10751072
34Alcoholism_Homo sapiens_hsa050341.09551053
35Homologous recombination_Homo sapiens_hsa034401.05315381
36Salmonella infection_Homo sapiens_hsa051321.05281180
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01081871
38Butanoate metabolism_Homo sapiens_hsa006500.99614702
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97146148
40Osteoclast differentiation_Homo sapiens_hsa043800.95003329
41Protein export_Homo sapiens_hsa030600.88113673
42Staphylococcus aureus infection_Homo sapiens_hsa051500.86787770
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86703422
44Ribosome_Homo sapiens_hsa030100.85996064
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84501116
46Prion diseases_Homo sapiens_hsa050200.81104087
47Alzheimers disease_Homo sapiens_hsa050100.78836449
48Asthma_Homo sapiens_hsa053100.77809958
49Viral carcinogenesis_Homo sapiens_hsa052030.75603366
50Herpes simplex infection_Homo sapiens_hsa051680.75532846
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.72824039
52Retinol metabolism_Homo sapiens_hsa008300.70394297
53B cell receptor signaling pathway_Homo sapiens_hsa046620.67422142
54Leishmaniasis_Homo sapiens_hsa051400.66976101
55Epstein-Barr virus infection_Homo sapiens_hsa051690.63709755
56Peroxisome_Homo sapiens_hsa041460.63157677
57Apoptosis_Homo sapiens_hsa042100.62926004
58Influenza A_Homo sapiens_hsa051640.51842272
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51345080
60RNA degradation_Homo sapiens_hsa030180.47487384
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44000469
62Mismatch repair_Homo sapiens_hsa034300.43976724
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42590765
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42374493
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42231489
66Nucleotide excision repair_Homo sapiens_hsa034200.42228301
67Collecting duct acid secretion_Homo sapiens_hsa049660.42014932
68N-Glycan biosynthesis_Homo sapiens_hsa005100.41684733
69Morphine addiction_Homo sapiens_hsa050320.39277664
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37556589
71Tuberculosis_Homo sapiens_hsa051520.37334611
72Huntingtons disease_Homo sapiens_hsa050160.36415269
73Phototransduction_Homo sapiens_hsa047440.36356994
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35734293
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34940581
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34694172
77TNF signaling pathway_Homo sapiens_hsa046680.33315282
78Malaria_Homo sapiens_hsa051440.32112240
79Nitrogen metabolism_Homo sapiens_hsa009100.28370905
80Propanoate metabolism_Homo sapiens_hsa006400.28087992
81Platelet activation_Homo sapiens_hsa046110.27135493
82HTLV-I infection_Homo sapiens_hsa051660.26362853
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.25669324
84Phagosome_Homo sapiens_hsa041450.24270688
85RNA polymerase_Homo sapiens_hsa030200.23839958
86Cholinergic synapse_Homo sapiens_hsa047250.23817239
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.23587351
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23569435
89Endocytosis_Homo sapiens_hsa041440.22365141
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.21455714
91African trypanosomiasis_Homo sapiens_hsa051430.20473903
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19817322
93Fanconi anemia pathway_Homo sapiens_hsa034600.16459024
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14794399
95Cardiac muscle contraction_Homo sapiens_hsa042600.14284997
96GABAergic synapse_Homo sapiens_hsa047270.12926479
97Ras signaling pathway_Homo sapiens_hsa040140.12847775
98Pancreatic cancer_Homo sapiens_hsa052120.10631476
99VEGF signaling pathway_Homo sapiens_hsa043700.07371139
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05442355

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