TRAF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.56320333
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.56320333
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.22946921
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.22946921
5modulation by symbiont of host immune response (GO:0052553)4.22946921
6positive regulation by symbiont of host defense response (GO:0052509)4.22946921
7modulation by symbiont of host defense response (GO:0052031)4.22946921
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.22946921
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.93941068
10response to muramyl dipeptide (GO:0032495)3.92720646
11positive regulation of gamma-delta T cell activation (GO:0046645)3.92383865
12response to peptidoglycan (GO:0032494)3.88425202
13macrophage activation involved in immune response (GO:0002281)3.81722635
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.80713376
15regulation of ARF protein signal transduction (GO:0032012)3.78473326
16synaptic vesicle maturation (GO:0016188)3.76338765
17positive thymic T cell selection (GO:0045059)3.69867580
18germinal center formation (GO:0002467)3.69472151
19negative thymic T cell selection (GO:0045060)3.66636218
20negative regulation of interleukin-12 production (GO:0032695)3.64211273
21activation of protein kinase A activity (GO:0034199)3.62656571
22thymic T cell selection (GO:0045061)3.50526686
23negative regulation of erythrocyte differentiation (GO:0045647)3.49699144
24negative T cell selection (GO:0043383)3.45319387
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.45015849
26antigen processing and presentation of endogenous antigen (GO:0019883)3.38398637
27regulation of gamma-delta T cell differentiation (GO:0045586)3.34751909
28locomotory exploration behavior (GO:0035641)3.33764520
29sodium ion export (GO:0071436)3.29897218
30T cell selection (GO:0045058)3.22450399
31layer formation in cerebral cortex (GO:0021819)3.20854744
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19551494
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19551494
34positive T cell selection (GO:0043368)3.18213208
35type I interferon signaling pathway (GO:0060337)3.17494557
36cellular response to type I interferon (GO:0071357)3.17494557
37response to type I interferon (GO:0034340)3.17407198
38regulation of interferon-beta biosynthetic process (GO:0045357)3.16078697
39regulation of gamma-delta T cell activation (GO:0046643)3.15352666
40regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12648260
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09009247
42response to host (GO:0075136)3.09009247
43response to host defenses (GO:0052200)3.09009247
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06924692
45cytoplasmic mRNA processing body assembly (GO:0033962)3.05231834
46regulation of NFAT protein import into nucleus (GO:0051532)3.02376228
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.02343976
48regulation of vitamin D biosynthetic process (GO:0060556)3.01509722
49detection of other organism (GO:0098543)3.01472545
50positive regulation of histone deacetylation (GO:0031065)3.00769751
51NIK/NF-kappaB signaling (GO:0038061)3.00590788
52negative regulation of toll-like receptor signaling pathway (GO:0034122)2.98222090
53T cell migration (GO:0072678)2.96558775
54immunoglobulin mediated immune response (GO:0016064)2.95296211
55response to host immune response (GO:0052572)2.95269012
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95269012
57regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94236452
58detection of bacterium (GO:0016045)2.94076282
59T-helper 1 type immune response (GO:0042088)2.91625314
60modulation by symbiont of host cellular process (GO:0044068)2.89447855
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86986814
62B cell homeostasis (GO:0001782)2.85848301
63myeloid dendritic cell activation (GO:0001773)2.85691711
64positive regulation of Rap GTPase activity (GO:0032854)2.85126151
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81813341
66activation of MAPKKK activity (GO:0000185)2.81193596
67regulation of interleukin-2 biosynthetic process (GO:0045076)2.81025870
68JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.76135306
69response to interleukin-15 (GO:0070672)2.74153510
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.73498201
71positive regulation of interferon-alpha production (GO:0032727)2.73321025
72cellular potassium ion homeostasis (GO:0030007)2.72369167
73detection of molecule of bacterial origin (GO:0032490)2.71704529
74protein localization to endosome (GO:0036010)2.69421232
75mannose metabolic process (GO:0006013)2.67825748
76regulation of interferon-alpha production (GO:0032647)2.67506824
77T cell lineage commitment (GO:0002360)2.66725965
78proline transport (GO:0015824)2.65651140
79regulation of early endosome to late endosome transport (GO:2000641)2.64425286
80nerve growth factor signaling pathway (GO:0038180)2.63761236
81response to laminar fluid shear stress (GO:0034616)2.63070478
82regulation of ARF GTPase activity (GO:0032312)2.62733299
83defense response to protozoan (GO:0042832)2.62666397
84regulation of podosome assembly (GO:0071801)2.62378483
85detection of external biotic stimulus (GO:0098581)2.62323315
86clathrin coat assembly (GO:0048268)2.60187246
87response to protozoan (GO:0001562)2.60020377
88regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59412601
89regulation of T-helper 1 cell differentiation (GO:0045625)2.54908872
90regulation of necroptotic process (GO:0060544)2.52080881
91regulation of vitamin metabolic process (GO:0030656)2.51558728
92negative regulation of myeloid cell apoptotic process (GO:0033033)2.51452737
93glial cell proliferation (GO:0014009)2.50385119
94positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50259501
95histone H3-K36 demethylation (GO:0070544)2.50208572
96regulation of Rap GTPase activity (GO:0032317)2.49528037
97signal complex assembly (GO:0007172)2.49273126
98regulation of synaptic vesicle exocytosis (GO:2000300)2.48788647
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.48310717
100stress fiber assembly (GO:0043149)2.48029793
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.47337554
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.45733409
103positive regulation of interleukin-2 production (GO:0032743)2.45240194
104dendritic cell differentiation (GO:0097028)2.44582679
105negative regulation of T cell mediated immunity (GO:0002710)2.44410760
106positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43601052
107regulation of T-helper 2 cell differentiation (GO:0045628)2.43519862
108positive regulation of type 2 immune response (GO:0002830)2.43503399
109cellular extravasation (GO:0045123)2.42210434
110regulation of synapse structural plasticity (GO:0051823)2.41114197
111response to nerve growth factor (GO:1990089)2.40713578
112cellular response to nerve growth factor stimulus (GO:1990090)2.40713578
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.40593876
114B cell proliferation (GO:0042100)2.39201301
115activation of Rac GTPase activity (GO:0032863)2.39035771
116negative regulation of fatty acid transport (GO:2000192)2.38650434
117activation of JUN kinase activity (GO:0007257)2.36164489
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36043435
119cellular response to interferon-gamma (GO:0071346)2.35724714
120corticosteroid receptor signaling pathway (GO:0031958)2.34642250
121NLS-bearing protein import into nucleus (GO:0006607)2.33591261
122tolerance induction (GO:0002507)2.32564981
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.31751577
124T cell costimulation (GO:0031295)2.31293691
125myeloid cell activation involved in immune response (GO:0002275)2.30880564
126glutamate secretion (GO:0014047)2.30684912
127B cell receptor signaling pathway (GO:0050853)2.30057306
128dendritic spine morphogenesis (GO:0060997)2.28901870
129negative regulation of cell size (GO:0045792)2.28829614
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.28306528
131positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.27448127
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.25550973
133peptidyl-threonine phosphorylation (GO:0018107)2.25439435
134myeloid dendritic cell differentiation (GO:0043011)2.24523793
135lymphocyte costimulation (GO:0031294)2.24205522
136peptidyl-threonine modification (GO:0018210)2.24027000
137establishment of protein localization to Golgi (GO:0072600)2.23790931
138synaptic vesicle exocytosis (GO:0016079)2.23442192
139dendrite morphogenesis (GO:0048813)2.23374958
140protein targeting to Golgi (GO:0000042)2.22276590
141cortical actin cytoskeleton organization (GO:0030866)2.21192287
142glucocorticoid receptor signaling pathway (GO:0042921)2.19728178
143peptidyl-lysine dimethylation (GO:0018027)2.19228135
144growth hormone receptor signaling pathway (GO:0060396)2.17571134
145regulation of T cell tolerance induction (GO:0002664)2.17102503
146natural killer cell differentiation (GO:0001779)2.16764385
147leukocyte aggregation (GO:0070486)2.16123849
148establishment of nucleus localization (GO:0040023)2.15173582
149potassium ion import (GO:0010107)2.14081066
150cellular response to interleukin-15 (GO:0071350)2.13576431
151plasma membrane repair (GO:0001778)2.12841669
152regulation of B cell receptor signaling pathway (GO:0050855)2.12422888
153positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.12419812
154interferon-gamma-mediated signaling pathway (GO:0060333)2.12062998
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.11483391
156pre-miRNA processing (GO:0031054)2.10608296
157cell communication by electrical coupling (GO:0010644)2.10079191
158positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.08260320
159exploration behavior (GO:0035640)2.08093747
160vesicle transport along microtubule (GO:0047496)2.05638374
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.04828589
162regulation of synaptic vesicle transport (GO:1902803)2.04516666
163regulation of clathrin-mediated endocytosis (GO:2000369)2.02023502
164leukocyte cell-cell adhesion (GO:0007159)2.01813890
165positive regulation of natural killer cell differentiation (GO:0032825)2.01537252
166regulation of defense response to virus by virus (GO:0050690)2.00567456
167positive regulation of tolerance induction (GO:0002645)2.00553018
168regulation of isotype switching to IgG isotypes (GO:0048302)1.99835782
169cellular sodium ion homeostasis (GO:0006883)1.98565539
170stress granule assembly (GO:0034063)1.97669980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84760594
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.61677673
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.48211950
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29959389
5MYC_22102868_ChIP-Seq_BL_Human3.08384380
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.02202235
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.82459183
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66822183
9KDM2B_26808549_Chip-Seq_DND41_Human2.60446365
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.42131405
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35013653
12TCF7_22412390_ChIP-Seq_EML_Mouse2.32575815
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.29503184
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27016309
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17149232
16VDR_21846776_ChIP-Seq_THP-1_Human2.10002861
17EZH2_22144423_ChIP-Seq_EOC_Human2.06273459
18KDM2B_26808549_Chip-Seq_K562_Human2.02629189
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.01476295
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95219037
21RUNX_20019798_ChIP-Seq_JUKART_Human1.92539894
22DROSHA_22980978_ChIP-Seq_HELA_Human1.91498121
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85578905
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.84169526
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83201452
26MAF_26560356_Chip-Seq_TH1_Human1.81153757
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70066076
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.69434461
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69219464
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69155477
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68974225
32* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68927566
33UTX_26944678_Chip-Seq_JUKART_Human1.67442177
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66175879
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63568713
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62054618
37* RARB_27405468_Chip-Seq_BRAIN_Mouse1.58790075
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58366159
39SPI1_23127762_ChIP-Seq_K562_Human1.57162090
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55408915
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54102993
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53457307
43LXR_22292898_ChIP-Seq_THP-1_Human1.52985355
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52269433
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.50662382
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48875918
47VDR_24763502_ChIP-Seq_THP-1_Human1.46928635
48* SPI1_23547873_ChIP-Seq_NB4_Human1.46374903
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46045651
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45129215
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43317653
52ZNF263_19887448_ChIP-Seq_K562_Human1.40702607
53MYB_26560356_Chip-Seq_TH2_Human1.39366840
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37833051
55* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37613720
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36759505
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34056826
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.33397625
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32027042
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31869890
61* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29158880
62* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25920701
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.25744428
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24043266
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23857629
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23639013
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22074627
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18816244
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16723529
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16463558
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16036110
72MYB_26560356_Chip-Seq_TH1_Human1.15984659
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15636143
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15082278
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14311198
76* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14038317
77NCOR1_26117541_ChIP-Seq_K562_Human1.13910377
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12102308
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11808335
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11278989
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10692179
82* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10522240
83CLOCK_20551151_ChIP-Seq_293T_Human1.09525269
84PU_27001747_Chip-Seq_BMDM_Mouse1.09492687
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09432149
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.09304289
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08368401
88MAF_26560356_Chip-Seq_TH2_Human1.08138734
89GATA3_27048872_Chip-Seq_THYMUS_Human1.07902547
90* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07507583
91* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06692935
92CREB1_26743006_Chip-Seq_LNCaP_Human1.06663953
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05927140
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05873120
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.05848021
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.05741193
97AHR_22903824_ChIP-Seq_MCF-7_Human1.05480933
98GATA1_22025678_ChIP-Seq_K562_Human1.04802630
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04787408
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.04039170
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04024040
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03812619
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03388237
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.02732922
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01877054
106* UBF1/2_26484160_Chip-Seq_HMECs_Human1.00835214
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00280556
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99930029
109ATF3_27146783_Chip-Seq_COLON_Human0.99679942
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.98903071
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98462433
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97863088
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97720427
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97156478
115SMC4_20622854_ChIP-Seq_HELA_Human0.96499604
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96428831
117TFEB_21752829_ChIP-Seq_HELA_Human0.96237792
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95945872
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94667193
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.94627115
121PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94568959
122VDR_24787735_ChIP-Seq_THP-1_Human0.94518081
123TP53_22127205_ChIP-Seq_IMR90_Human0.94275164
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94175007
125GATA1_19941826_ChIP-Seq_K562_Human0.93559229
126SCL_19346495_ChIP-Seq_HPC-7_Human0.93388413
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.93250576
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.93250576
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92258015
130* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91916297
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91594108
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.91580099
133* P68_20966046_ChIP-Seq_HELA_Human0.91256809
134RNF2_27304074_Chip-Seq_ESCs_Mouse0.90583077
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90442155
136RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89364734
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89364734
138AR_21572438_ChIP-Seq_LNCaP_Human0.88736542
139REST_21632747_ChIP-Seq_MESCs_Mouse0.88443458
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88185161
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87510227
142JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87131194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.84499266
2MP0004859_abnormal_synaptic_plasticity3.67870267
3MP0003300_gastrointestinal_ulcer3.49331032
4MP0000569_abnormal_digit_pigmentation3.05990607
5MP0004510_myositis3.04853584
6MP0010234_abnormal_vibrissa_follicle2.63150887
7MP0005076_abnormal_cell_differentiation2.62861578
8MP0005451_abnormal_body_composition2.48884994
9MP0008961_abnormal_basal_metabolism2.46703176
10MP0000685_abnormal_immune_system2.44655872
11MP0002877_abnormal_melanocyte_morpholog2.25157873
12MP0005058_abnormal_lysosome_morphology2.24735594
13MP0005387_immune_system_phenotype2.20263885
14MP0001790_abnormal_immune_system2.20263885
15MP0009840_abnormal_foam_cell2.11111116
16MP0002148_abnormal_hypersensitivity_rea2.07199252
17MP0010352_gastrointestinal_tract_polyps2.06160122
18MP0002166_altered_tumor_susceptibility1.95456039
19MP0001835_abnormal_antigen_presentation1.94315057
20MP0001348_abnormal_lacrimal_gland1.94169322
21MP0004858_abnormal_nervous_system1.91151831
22MP0003763_abnormal_thymus_physiology1.90984245
23MP0003787_abnormal_imprinting1.88947081
24MP0009333_abnormal_splenocyte_physiolog1.88443798
25MP0001800_abnormal_humoral_immune1.82996332
26MP0003191_abnormal_cellular_cholesterol1.82426661
27MP0003705_abnormal_hypodermis_morpholog1.79490270
28MP0002909_abnormal_adrenal_gland1.78715370
29MP0003724_increased_susceptibility_to1.76020250
30MP0006082_CNS_inflammation1.75657885
31MP0009780_abnormal_chondrocyte_physiolo1.70658143
32MP0008260_abnormal_autophagy1.70564334
33MP0003045_fibrosis1.68423777
34MP0003091_abnormal_cell_migration1.65340039
35MP0003635_abnormal_synaptic_transmissio1.65190890
36MP0003436_decreased_susceptibility_to1.64063688
37MP0005000_abnormal_immune_tolerance1.59617123
38MP0002006_tumorigenesis1.56980476
39MP0000858_altered_metastatic_potential1.52757541
40MP0001873_stomach_inflammation1.51756448
41MP0004808_abnormal_hematopoietic_stem1.50430827
42MP0005671_abnormal_response_to1.50290259
43MP0002452_abnormal_antigen_presenting1.47626218
44MP0001853_heart_inflammation1.43576409
45MP0003172_abnormal_lysosome_physiology1.39647301
46MP0002138_abnormal_hepatobiliary_system1.38950984
47MP0002420_abnormal_adaptive_immunity1.38545726
48MP0001819_abnormal_immune_cell1.36749807
49MP0002723_abnormal_immune_serum1.35650817
50* MP0002398_abnormal_bone_marrow1.32845091
51MP0010155_abnormal_intestine_physiology1.32366129
52MP0005623_abnormal_meninges_morphology1.31805532
53MP0003183_abnormal_peptide_metabolism1.30330622
54MP0002254_reproductive_system_inflammat1.29091406
55MP0000604_amyloidosis1.28838368
56MP0005310_abnormal_salivary_gland1.26881747
57MP0004270_analgesia1.26742444
58MP0009278_abnormal_bone_marrow1.25156418
59MP0005464_abnormal_platelet_physiology1.23664748
60MP0002063_abnormal_learning/memory/cond1.22986273
61MP0004811_abnormal_neuron_physiology1.18707695
62MP0004947_skin_inflammation1.17068341
63* MP0000716_abnormal_immune_system1.16549791
64* MP0000703_abnormal_thymus_morphology1.15389542
65MP0008569_lethality_at_weaning1.13887128
66MP0003866_abnormal_defecation1.12200503
67MP0003329_amyloid_beta_deposits1.10880272
68MP0000003_abnormal_adipose_tissue1.10352893
69MP0000733_abnormal_muscle_development1.09783128
70MP0008469_abnormal_protein_level1.08200122
71MP0002405_respiratory_system_inflammati1.05538166
72MP0002928_abnormal_bile_duct1.04767039
73MP0005423_abnormal_somatic_nervous1.00172277
74MP0003828_pulmonary_edema0.99467159
75MP0000490_abnormal_crypts_of0.98810143
76MP0003075_altered_response_to0.97910354
77MP0000343_altered_response_to0.97251034
78MP0010307_abnormal_tumor_latency0.95466151
79MP0003566_abnormal_cell_adhesion0.94317999
80MP0009764_decreased_sensitivity_to0.93681519
81MP0005257_abnormal_intraocular_pressure0.93516170
82MP0002419_abnormal_innate_immunity0.91763287
83MP0005397_hematopoietic_system_phenotyp0.91669045
84MP0001545_abnormal_hematopoietic_system0.91669045
85MP0005167_abnormal_blood-brain_barrier0.91575183
86MP0005025_abnormal_response_to0.90104052
87MP0002722_abnormal_immune_system0.88706777
88MP0004130_abnormal_muscle_cell0.87539116
89MP0005187_abnormal_penis_morphology0.87087426
90MP0002998_abnormal_bone_remodeling0.86969804
91MP0002184_abnormal_innervation0.86494762
92MP0005645_abnormal_hypothalamus_physiol0.86154607
93MP0001984_abnormal_olfaction0.86066761
94MP0001533_abnormal_skeleton_physiology0.85267417
95MP0002089_abnormal_postnatal_growth/wei0.84187870
96MP0003656_abnormal_erythrocyte_physiolo0.84081846
97MP0000689_abnormal_spleen_morphology0.83906668
98MP0001845_abnormal_inflammatory_respons0.83569676
99MP0005023_abnormal_wound_healing0.82599955
100MP0005621_abnormal_cell_physiology0.81099603
101MP0005666_abnormal_adipose_tissue0.80837215
102* MP0002429_abnormal_blood_cell0.80823558
103MP0002139_abnormal_hepatobiliary_system0.78530112
104MP0001299_abnormal_eye_distance/0.77676670
105MP0005375_adipose_tissue_phenotype0.77644385
106MP0005390_skeleton_phenotype0.76481398
107MP0009785_altered_susceptibility_to0.76389467
108MP0000013_abnormal_adipose_tissue0.76328898
109MP0005409_darkened_coat_color0.75720429
110MP0002735_abnormal_chemical_nociception0.75303179
111MP0001663_abnormal_digestive_system0.74218145
112MP0000778_abnormal_nervous_system0.74142216
113MP0000465_gastrointestinal_hemorrhage0.74037101
114MP0002064_seizures0.73969180
115MP0001501_abnormal_sleep_pattern0.73803764
116MP0003448_altered_tumor_morphology0.72850250
117MP0008057_abnormal_DNA_replication0.72113926
118MP0002693_abnormal_pancreas_physiology0.72087264
119MP0001851_eye_inflammation0.71689844
120MP0005394_taste/olfaction_phenotype0.71352669
121MP0005499_abnormal_olfactory_system0.71352669
122MP0001849_ear_inflammation0.71149040
123MP0009745_abnormal_behavioral_response0.71139616
124MP0003795_abnormal_bone_structure0.71072032
125MP0001216_abnormal_epidermal_layer0.69862572
126MP0004087_abnormal_muscle_fiber0.68371142
127MP0002234_abnormal_pharynx_morphology0.67147061
128MP0004185_abnormal_adipocyte_glucose0.66510063
129MP0002396_abnormal_hematopoietic_system0.65598492
130MP0002933_joint_inflammation0.65102630
131MP0002009_preneoplasia0.65082780
132MP0008874_decreased_physiological_sensi0.64839539
133MP0010630_abnormal_cardiac_muscle0.64811233
134MP0004233_abnormal_muscle_weight0.64335171
135MP0003633_abnormal_nervous_system0.63606333
136MP0005166_decreased_susceptibility_to0.63363581
137MP0003453_abnormal_keratinocyte_physiol0.61768199

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)3.95440450
2Abnormality of macrophages (HP:0004311)3.31435811
3Abnormality of glycolipid metabolism (HP:0010969)3.27081791
4Abnormality of liposaccharide metabolism (HP:0010968)3.27081791
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.27081791
6Hyperacusis (HP:0010780)3.25747026
7Mediastinal lymphadenopathy (HP:0100721)3.25218002
8Macroorchidism (HP:0000053)3.22923780
9Recurrent bacterial skin infections (HP:0005406)3.22419390
10Recurrent abscess formation (HP:0002722)3.05442163
11Papilledema (HP:0001085)2.95805311
12Cerebral aneurysm (HP:0004944)2.83272953
13Increased density of long bones (HP:0006392)2.68291072
14Meningitis (HP:0001287)2.60128251
15Dysostosis multiplex (HP:0000943)2.55237007
16Abnormality of the fingertips (HP:0001211)2.55036606
17IgA deficiency (HP:0002720)2.54548690
18Orchitis (HP:0100796)2.54394682
19Eczematoid dermatitis (HP:0000976)2.48184327
20Subacute progressive viral hepatitis (HP:0006572)2.45907403
21Gingivitis (HP:0000230)2.41015022
22Supranuclear gaze palsy (HP:0000605)2.40097798
23Loss of speech (HP:0002371)2.38403729
24Restrictive lung disease (HP:0002091)2.37613699
25Recurrent sinusitis (HP:0011108)2.35910930
26Retrobulbar optic neuritis (HP:0100654)2.34834712
27Optic neuritis (HP:0100653)2.34834712
28Elfin facies (HP:0004428)2.34801862
29Neurofibrillary tangles (HP:0002185)2.33643966
30Recurrent fungal infections (HP:0002841)2.32162449
31Thin bony cortex (HP:0002753)2.30573213
32Cerebral inclusion bodies (HP:0100314)2.29124393
33Persistence of primary teeth (HP:0006335)2.28430059
34Lymphopenia (HP:0001888)2.27033068
35Increased cerebral lipofuscin (HP:0011813)2.26820194
36Insomnia (HP:0100785)2.26375997
37Absent frontal sinuses (HP:0002688)2.25199662
38Vertebral arch anomaly (HP:0008438)2.24563179
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.23741610
40Slow saccadic eye movements (HP:0000514)2.22906604
41Colitis (HP:0002583)2.21201549
42Broad face (HP:0000283)2.20241098
43Neuronal loss in central nervous system (HP:0002529)2.20031771
44Frequent falls (HP:0002359)2.18463439
45Distal upper limb amyotrophy (HP:0007149)2.17717663
46Upper limb amyotrophy (HP:0009129)2.17717663
47Fatigue (HP:0012378)2.15610733
48Enlarged penis (HP:0000040)2.15588592
49Abnormality of the nasal mucosa (HP:0000433)2.15066089
50Segmental peripheral demyelination/remyelination (HP:0003481)2.14741996
51Pointed chin (HP:0000307)2.13274548
52Obstructive lung disease (HP:0006536)2.12078425
53Chronic obstructive pulmonary disease (HP:0006510)2.12078425
54Recurrent skin infections (HP:0001581)2.10652278
55Hemiplegia (HP:0002301)2.09948198
56Spondylolisthesis (HP:0003302)2.09779444
57Recurrent gram-negative bacterial infections (HP:0005420)2.07991742
58Recurrent viral infections (HP:0004429)2.07980046
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.07544428
60Apathy (HP:0000741)2.06704871
61Visual hallucinations (HP:0002367)2.06314016
62Lower limb amyotrophy (HP:0007210)2.06161566
63Malnutrition (HP:0004395)2.03756320
64T lymphocytopenia (HP:0005403)2.03456770
65Gastrointestinal inflammation (HP:0004386)2.01707827
66Cellulitis (HP:0100658)2.01667576
67Hypercortisolism (HP:0001578)2.00750446
68Hand muscle atrophy (HP:0009130)1.99309190
69Inflammation of the large intestine (HP:0002037)1.99032313
70Dilatation of the ascending aorta (HP:0005111)1.98252623
71Papilloma (HP:0012740)1.98217709
72Verrucae (HP:0200043)1.98217709
73Urinary urgency (HP:0000012)1.97782378
74Long toe (HP:0010511)1.97550612
75Spontaneous hematomas (HP:0007420)1.97470740
76Osteomyelitis (HP:0002754)1.96761616
77Obstructive sleep apnea (HP:0002870)1.94946488
78Chronic otitis media (HP:0000389)1.93789348
79Abnormality of oral frenula (HP:0000190)1.92485307
80Vertebral compression fractures (HP:0002953)1.92105130
81Abnormality of the thoracic spine (HP:0100711)1.92072206
82Ankyloglossia (HP:0010296)1.91477386
83Inappropriate behavior (HP:0000719)1.91206378
84Long palpebral fissure (HP:0000637)1.91032614
85Diminished motivation (HP:0000745)1.90923642
86Gastrointestinal infarctions (HP:0005244)1.90337959
87Thoracic kyphosis (HP:0002942)1.89563155
88Shallow orbits (HP:0000586)1.89506253
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89339135
90Recurrent cutaneous fungal infections (HP:0011370)1.87708881
91Chronic mucocutaneous candidiasis (HP:0002728)1.87708881
92Vacuolated lymphocytes (HP:0001922)1.87657171
93Mitral valve prolapse (HP:0001634)1.87511355
94Viral hepatitis (HP:0006562)1.87400230
95Narrow palate (HP:0000189)1.87205148
96Mucopolysacchariduria (HP:0008155)1.86671152
97Urinary glycosaminoglycan excretion (HP:0003541)1.86671152
98Upper motor neuron abnormality (HP:0002127)1.86414582
99Focal seizures (HP:0007359)1.85781079
100Urticaria (HP:0001025)1.85057688
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84900474
102Bowel diverticulosis (HP:0005222)1.84627498
103Chronic diarrhea (HP:0002028)1.84028168
104Flat acetabular roof (HP:0003180)1.83752140
105Renovascular hypertension (HP:0100817)1.83740998
106Dysmetric saccades (HP:0000641)1.83658907
107Recurrent lower respiratory tract infections (HP:0002783)1.83369857
108Chest pain (HP:0100749)1.82589728
109Abnormality of polysaccharide metabolism (HP:0011012)1.81988025
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81988025
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81988025
112Syringomyelia (HP:0003396)1.81559205
113Spinal cord lesions (HP:0100561)1.81559205
114Abnormality of T cell number (HP:0011839)1.81105914
115Arterial thrombosis (HP:0004420)1.80867767
116Urinary bladder sphincter dysfunction (HP:0002839)1.78732563
117Autoimmune hemolytic anemia (HP:0001890)1.78550024
118Abnormality of the gastric mucosa (HP:0004295)1.77459391
119Bone pain (HP:0002653)1.77236471
120Recurrent pneumonia (HP:0006532)1.77107385
121Pelvic girdle muscle weakness (HP:0003749)1.76549303
122Overriding aorta (HP:0002623)1.76021061
123Premature loss of primary teeth (HP:0006323)1.75302870
124Hypertensive crisis (HP:0100735)1.74933037
125Heterotopia (HP:0002282)1.74913087
126Arthralgia (HP:0002829)1.73305412
127Truncal ataxia (HP:0002078)1.72372378
128Neoplasm of the heart (HP:0100544)1.71172720
129Recurrent bronchitis (HP:0002837)1.70964970
130Hematochezia (HP:0002573)1.70558325
131Myocardial infarction (HP:0001658)1.69859872
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.69247253
133Agammaglobulinemia (HP:0004432)1.68693215
134Stomatitis (HP:0010280)1.68385918
135Striae distensae (HP:0001065)1.68173824
136Deep palmar crease (HP:0006191)1.66637093
137Action tremor (HP:0002345)1.66025154
138Myokymia (HP:0002411)1.65721927
139Increased IgE level (HP:0003212)1.65541538
140Nasal polyposis (HP:0100582)1.65330133
141Emphysema (HP:0002097)1.64402535
142Depression (HP:0000716)1.64020504
143Aneurysm (HP:0002617)1.63912140
144Achilles tendon contracture (HP:0001771)1.62977686
145Myositis (HP:0100614)1.62705227
146Ankle clonus (HP:0011448)1.61603178
147Abnormality of the lower motor neuron (HP:0002366)1.61070204
148Absence seizures (HP:0002121)1.60565144
149Aortic aneurysm (HP:0004942)1.60561440
150Radial bowing (HP:0002986)1.60533076
151Aqueductal stenosis (HP:0002410)1.60079639
152Interstitial pulmonary disease (HP:0006530)1.59844248
153Transitional cell carcinoma of the bladder (HP:0006740)1.59509959
154Obsessive-compulsive behavior (HP:0000722)1.58914200
155Genetic anticipation (HP:0003743)1.58750385
156Autoimmune thrombocytopenia (HP:0001973)1.57933939
157Distal lower limb amyotrophy (HP:0008944)1.56557182
158Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56230307
159Renal duplication (HP:0000075)1.56139220
160Mask-like facies (HP:0000298)1.55683508
161Annular pancreas (HP:0001734)1.54842260
162Difficulty running (HP:0009046)1.54838098
163Pulmonary infiltrates (HP:0002113)1.54569951
164Open mouth (HP:0000194)1.54144682
165Bladder carcinoma (HP:0002862)1.52546130
166Bladder neoplasm (HP:0009725)1.52546130
167Vasculitis (HP:0002633)1.52506112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.99994861
2TRIB33.55525261
3IRAK33.52920967
4SMG12.57268828
5EEF2K2.56388950
6MAP4K12.53078068
7SIK22.50867636
8PKN22.42707331
9MAP3K92.40418455
10MAP3K102.38307342
11PTK61.96086500
12BLK1.95850512
13IRAK41.93432570
14TTN1.82419277
15ALK1.77747471
16MAP3K131.74774331
17JAK11.72372066
18RIPK11.72016191
19NME21.62118308
20CDK121.55708669
21CAMK1G1.53915368
22MARK11.53728241
23MAP2K31.51992526
24PRKD31.49782453
25TAOK21.47202986
26DMPK1.45920903
27TAOK11.43555989
28JAK31.43066955
29KSR21.39215636
30PRKCH1.38475213
31FGFR31.35111022
32PAK61.28561976
33CAMKK11.26562544
34EPHB11.25803957
35MAP3K141.25458267
36NEK91.24294551
37ERN11.23542928
38TYK21.23440076
39GRK61.23207500
40MAP3K71.23107339
41DAPK21.21700522
42DDR21.19868448
43FGFR41.19695778
44MINK11.17552477
45NTRK21.15778007
46MAP3K111.12925425
47NTRK31.11783065
48RET1.09435354
49BMX1.07432823
50CHUK1.06992775
51HCK1.02952389
52MAP3K31.01561427
53CSF1R1.00669759
54LMTK20.99330668
55SCYL20.98982799
56MAP3K20.98730719
57IRAK20.98693038
58SIK30.98686643
59ARAF0.98265250
60FGR0.98141419
61HIPK20.97461606
62ERBB30.97331440
63ZAP700.97313149
64PDGFRA0.96737892
65TBK10.96511773
66ITK0.94433045
67FES0.93517692
68STK110.92323460
69LRRK20.89956165
70BMPR20.88603947
71MAP3K40.87746699
72KSR10.87384572
73MATK0.86970696
74SGK30.86464316
75PAK30.85953081
76JAK20.84895956
77PHKG10.84799503
78PHKG20.84799503
79PDPK10.84329281
80CAMK1D0.82560276
81NTRK10.80921908
82MAPK110.79586013
83SIK10.79113233
84CDK40.78716017
85SYK0.78168070
86MOS0.77169969
87MAP3K10.76940498
88MARK20.75755521
89RIPK40.75546940
90STK100.73838851
91MTOR0.72208500
92TYRO30.71101308
93TXK0.69108549
94MELK0.69028087
95EPHA30.68985836
96CDC42BPA0.68748308
97MAP3K80.68129537
98CDK50.65436222
99BRAF0.63501206
100BRD40.62485519
101CSK0.61971100
102PDGFRB0.61968854
103IKBKE0.61279737
104RPS6KA20.60740258
105PIM20.58711616
106PDK10.57686932
107LYN0.57471444
108FYN0.57459939
109RPS6KC10.54070491
110RPS6KL10.54070491
111STK380.53737062
112IRAK10.52789187
113FRK0.52694493
114PASK0.51876509
115CDK60.51691510
116BTK0.50459801
117PRKCZ0.50146151
118TESK20.49564546
119EGFR0.49443916
120DYRK1B0.47978523
121LCK0.47961904
122MST1R0.47455469
123MAPK120.47048634
124IKBKB0.46091220
125MARK30.45110810
126TGFBR20.43909376
127MAP2K20.42737094
128SGK10.42478926
129MAPK70.40535719
130PRKD10.40373097
131RPS6KA10.40034017
132MAP2K40.39803183
133PTK20.39724006
134GSK3A0.39560302
135ICK0.38973887
136ROCK20.37020013
137PRKD20.36737575
138MAPK80.36733134
139SRC0.36383740
140KIT0.36179059
141TAOK30.35803463

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046721.93523502
2Other glycan degradation_Homo sapiens_hsa005111.85714425
3Autoimmune thyroid disease_Homo sapiens_hsa053201.84578826
4Graft-versus-host disease_Homo sapiens_hsa053321.84190346
5Olfactory transduction_Homo sapiens_hsa047401.75680198
6B cell receptor signaling pathway_Homo sapiens_hsa046621.74715813
7Asthma_Homo sapiens_hsa053101.57128247
8T cell receptor signaling pathway_Homo sapiens_hsa046601.53117028
9Chronic myeloid leukemia_Homo sapiens_hsa052201.51697901
10Type II diabetes mellitus_Homo sapiens_hsa049301.50329927
11Neurotrophin signaling pathway_Homo sapiens_hsa047221.47791914
12Osteoclast differentiation_Homo sapiens_hsa043801.44814906
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44062400
14Glioma_Homo sapiens_hsa052141.41443929
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37996015
16Staphylococcus aureus infection_Homo sapiens_hsa051501.37061099
17* Herpes simplex infection_Homo sapiens_hsa051681.31336421
18* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30312676
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29213320
20Leishmaniasis_Homo sapiens_hsa051401.27497540
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27490604
22Dorso-ventral axis formation_Homo sapiens_hsa043201.27232386
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27205205
24* Hepatitis C_Homo sapiens_hsa051601.25976205
25Prolactin signaling pathway_Homo sapiens_hsa049171.25221437
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25025136
27Chemokine signaling pathway_Homo sapiens_hsa040621.22488491
28mTOR signaling pathway_Homo sapiens_hsa041501.21711794
29Endometrial cancer_Homo sapiens_hsa052131.19701788
30Bladder cancer_Homo sapiens_hsa052191.18994995
31Viral myocarditis_Homo sapiens_hsa054161.17971564
32Long-term potentiation_Homo sapiens_hsa047201.17695585
33Non-small cell lung cancer_Homo sapiens_hsa052231.17183770
34Estrogen signaling pathway_Homo sapiens_hsa049151.16098745
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15749716
36Insulin secretion_Homo sapiens_hsa049111.13759758
37Gastric acid secretion_Homo sapiens_hsa049711.13597559
38Primary immunodeficiency_Homo sapiens_hsa053401.13403814
39Toxoplasmosis_Homo sapiens_hsa051451.13377759
40Acute myeloid leukemia_Homo sapiens_hsa052211.13130281
41Rheumatoid arthritis_Homo sapiens_hsa053231.12732890
42Cholinergic synapse_Homo sapiens_hsa047251.11990549
43Pancreatic cancer_Homo sapiens_hsa052121.11906637
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10136852
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09598330
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09220505
47Malaria_Homo sapiens_hsa051441.09189218
48GnRH signaling pathway_Homo sapiens_hsa049121.08790610
49Lysosome_Homo sapiens_hsa041421.07603178
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06926609
51VEGF signaling pathway_Homo sapiens_hsa043701.06579029
52* TNF signaling pathway_Homo sapiens_hsa046681.06211862
53Type I diabetes mellitus_Homo sapiens_hsa049401.04013421
54Renal cell carcinoma_Homo sapiens_hsa052111.03676305
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02668398
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02249815
57Circadian entrainment_Homo sapiens_hsa047131.01797277
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01010252
59* NF-kappa B signaling pathway_Homo sapiens_hsa040641.00720186
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98953056
61Legionellosis_Homo sapiens_hsa051340.98811211
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98475257
63Hematopoietic cell lineage_Homo sapiens_hsa046400.97442134
64ErbB signaling pathway_Homo sapiens_hsa040120.97351016
65MAPK signaling pathway_Homo sapiens_hsa040100.95629313
66* Epstein-Barr virus infection_Homo sapiens_hsa051690.95185219
67Colorectal cancer_Homo sapiens_hsa052100.94739813
68Oxytocin signaling pathway_Homo sapiens_hsa049210.94011300
69Prion diseases_Homo sapiens_hsa050200.92264054
70Morphine addiction_Homo sapiens_hsa050320.92009022
71Synaptic vesicle cycle_Homo sapiens_hsa047210.91894940
72Pertussis_Homo sapiens_hsa051330.90839792
73Proteoglycans in cancer_Homo sapiens_hsa052050.90416628
74* Viral carcinogenesis_Homo sapiens_hsa052030.89393273
75Dopaminergic synapse_Homo sapiens_hsa047280.89032878
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.88570400
77Insulin signaling pathway_Homo sapiens_hsa049100.88479717
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.88105351
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.87658955
80Measles_Homo sapiens_hsa051620.87178771
81Salivary secretion_Homo sapiens_hsa049700.87025591
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86798722
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.86293551
84Gap junction_Homo sapiens_hsa045400.85922052
85Phagosome_Homo sapiens_hsa041450.85526195
86Dilated cardiomyopathy_Homo sapiens_hsa054140.85142934
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.85121259
88Platelet activation_Homo sapiens_hsa046110.84737023
89Tuberculosis_Homo sapiens_hsa051520.84627072
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84508329
91Hepatitis B_Homo sapiens_hsa051610.83843549
92* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83684031
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83422836
94Prostate cancer_Homo sapiens_hsa052150.83110605
95Renin secretion_Homo sapiens_hsa049240.83031848
96Insulin resistance_Homo sapiens_hsa049310.82718284
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81283290
98Glutamatergic synapse_Homo sapiens_hsa047240.80159965
99GABAergic synapse_Homo sapiens_hsa047270.79620695
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79361420
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79282965
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79219691
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78702924
104Focal adhesion_Homo sapiens_hsa045100.78120629
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78104079
106Endocytosis_Homo sapiens_hsa041440.77526635
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76565042
108Antigen processing and presentation_Homo sapiens_hsa046120.76381218
109cAMP signaling pathway_Homo sapiens_hsa040240.75654512
110Rap1 signaling pathway_Homo sapiens_hsa040150.74617508
111Shigellosis_Homo sapiens_hsa051310.73706486
112Salmonella infection_Homo sapiens_hsa051320.73615475
113* Small cell lung cancer_Homo sapiens_hsa052220.72914477
114Apoptosis_Homo sapiens_hsa042100.72412823
115Allograft rejection_Homo sapiens_hsa053300.71779000
116Amoebiasis_Homo sapiens_hsa051460.71193573
117HIF-1 signaling pathway_Homo sapiens_hsa040660.70871435
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.70856389
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.70324036
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68708018
121African trypanosomiasis_Homo sapiens_hsa051430.68011957
122Cocaine addiction_Homo sapiens_hsa050300.67671176
123MicroRNAs in cancer_Homo sapiens_hsa052060.67628359
124Choline metabolism in cancer_Homo sapiens_hsa052310.66748290
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66673226
126Influenza A_Homo sapiens_hsa051640.66410031
127Amphetamine addiction_Homo sapiens_hsa050310.66310006
128Melanogenesis_Homo sapiens_hsa049160.65674544
129HTLV-I infection_Homo sapiens_hsa051660.65652823
130Notch signaling pathway_Homo sapiens_hsa043300.65250063
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63172856
132Thyroid cancer_Homo sapiens_hsa052160.59372589
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59194506
134FoxO signaling pathway_Homo sapiens_hsa040680.56161562
135Inositol phosphate metabolism_Homo sapiens_hsa005620.52888710
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48089670

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