TRADD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.15726577
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15726577
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93666711
4negative regulation of cell killing (GO:0031342)4.93666711
5antigen processing and presentation of endogenous antigen (GO:0019883)4.53416170
6DNA deamination (GO:0045006)3.99433665
7positive regulation of gamma-delta T cell activation (GO:0046645)3.93431526
8Arp2/3 complex-mediated actin nucleation (GO:0034314)3.92038875
9ribosomal small subunit assembly (GO:0000028)3.78409733
10viral transcription (GO:0019083)3.76716597
11negative regulation of interleukin-12 production (GO:0032695)3.62634831
12translational termination (GO:0006415)3.60009405
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.56787211
14negative T cell selection (GO:0043383)3.52959630
15negative thymic T cell selection (GO:0045060)3.52941725
16detection of bacterium (GO:0016045)3.50222397
17response to peptidoglycan (GO:0032494)3.48974923
18detection of other organism (GO:0098543)3.45903224
19positive thymic T cell selection (GO:0045059)3.42751549
20regulation of T cell tolerance induction (GO:0002664)3.40888796
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35109545
22modulation by symbiont of host defense response (GO:0052031)3.33991484
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33991484
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33991484
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.33991484
26modulation by symbiont of host immune response (GO:0052553)3.33991484
27positive regulation by symbiont of host defense response (GO:0052509)3.33991484
28protein targeting to ER (GO:0045047)3.33925448
29ribosomal small subunit biogenesis (GO:0042274)3.32417946
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28440709
31pentose-phosphate shunt (GO:0006098)3.27612794
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26530409
33cotranslational protein targeting to membrane (GO:0006613)3.25370229
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23225166
35response to interleukin-15 (GO:0070672)3.22609398
36protein localization to endoplasmic reticulum (GO:0070972)3.20816619
37regulation of tolerance induction (GO:0002643)3.20548213
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20494117
39regulation of T cell mediated cytotoxicity (GO:0001914)3.16794140
40thymic T cell selection (GO:0045061)3.16404603
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15620228
42response to muramyl dipeptide (GO:0032495)3.15203144
43cellular response to interleukin-15 (GO:0071350)3.14891657
44translational elongation (GO:0006414)3.14873781
45regulation of gamma-delta T cell differentiation (GO:0045586)3.12501273
46granulocyte activation (GO:0036230)3.12117071
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11918213
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11308612
49myeloid dendritic cell differentiation (GO:0043011)3.10884423
50macrophage activation involved in immune response (GO:0002281)3.09551760
51dendritic cell chemotaxis (GO:0002407)3.06396881
52neutrophil activation (GO:0042119)3.04453357
53positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04431967
54regulation of alpha-beta T cell proliferation (GO:0046640)3.03167618
55positive regulation of B cell differentiation (GO:0045579)3.02968785
56positive regulation of tolerance induction (GO:0002645)3.02279345
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.02248141
58negative regulation of leukocyte mediated immunity (GO:0002704)3.01979928
59antigen processing and presentation via MHC class Ib (GO:0002475)3.00524319
60regulation of antigen processing and presentation (GO:0002577)3.00503450
61response to type I interferon (GO:0034340)2.98403643
62NADPH regeneration (GO:0006740)2.98172616
63T cell selection (GO:0045058)2.97916261
64type I interferon signaling pathway (GO:0060337)2.96684802
65cellular response to type I interferon (GO:0071357)2.96684802
66myeloid dendritic cell activation (GO:0001773)2.94165729
67viral life cycle (GO:0019058)2.93944025
68negative regulation of T cell mediated immunity (GO:0002710)2.93636401
69regulation of T-helper 1 cell differentiation (GO:0045625)2.92705969
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92053566
71regulation of natural killer cell mediated immunity (GO:0002715)2.92053566
72positive regulation of antigen processing and presentation (GO:0002579)2.89958504
73germinal center formation (GO:0002467)2.87874279
74regulation of gamma-delta T cell activation (GO:0046643)2.87103540
75regulation of regulatory T cell differentiation (GO:0045589)2.87036837
76lymphocyte chemotaxis (GO:0048247)2.86237722
77negative regulation of cytokine production involved in immune response (GO:0002719)2.85331434
78response to interferon-beta (GO:0035456)2.84146488
79negative regulation of innate immune response (GO:0045824)2.83580765
80actin nucleation (GO:0045010)2.82847154
81regulation of chronic inflammatory response (GO:0002676)2.82801003
82negative regulation of viral genome replication (GO:0045071)2.82742834
83B cell receptor signaling pathway (GO:0050853)2.81228897
84positive T cell selection (GO:0043368)2.80635163
85detection of external biotic stimulus (GO:0098581)2.79816697
86immunoglobulin mediated immune response (GO:0016064)2.79296836
87regulation of leukocyte mediated cytotoxicity (GO:0001910)2.74967895
88regulation of interleukin-2 biosynthetic process (GO:0045076)2.74033904
89positive regulation of type 2 immune response (GO:0002830)2.72433884
90cellular protein complex disassembly (GO:0043624)2.72356725
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71688430
92regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71434741
93negative regulation of erythrocyte differentiation (GO:0045647)2.70850908
94NIK/NF-kappaB signaling (GO:0038061)2.70425433
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.68246179
96myeloid cell activation involved in immune response (GO:0002275)2.67909498
97cellular response to interferon-gamma (GO:0071346)2.65952117
98lymphocyte migration (GO:0072676)2.65654142
99negative regulation of type I interferon production (GO:0032480)2.65504626
100translational initiation (GO:0006413)2.65118722
101T-helper 1 type immune response (GO:0042088)2.64155705
102mature B cell differentiation (GO:0002335)2.63346705
103negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.62394685
104amyloid precursor protein catabolic process (GO:0042987)2.62247132
105regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.62067824
106nucleoside salvage (GO:0043174)2.61957666
107leukocyte aggregation (GO:0070486)2.59148993
108regulation of B cell differentiation (GO:0045577)2.54638271
109defense response to protozoan (GO:0042832)2.51772475
110cellular response to interferon-beta (GO:0035458)2.50910695
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50586794
112regulation of protein heterodimerization activity (GO:0043497)2.50402027
113negative regulation of phagocytosis (GO:0050765)2.47524907
114B cell mediated immunity (GO:0019724)2.47508180
115maturation of SSU-rRNA (GO:0030490)2.46529319
116nucleotide salvage (GO:0043173)2.46342821
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.45008480
118response to protozoan (GO:0001562)2.44698846
119antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43815486
120regulation of T cell receptor signaling pathway (GO:0050856)2.42974630
121cellular response to exogenous dsRNA (GO:0071360)2.42457864
122neutrophil activation involved in immune response (GO:0002283)2.42214988
123regulation of B cell receptor signaling pathway (GO:0050855)2.40808464
124respiratory burst (GO:0045730)2.39802859
125purine nucleotide salvage (GO:0032261)2.39685404
126positive regulation of natural killer cell differentiation (GO:0032825)2.36326549
127purine-containing compound salvage (GO:0043101)2.32124604
128glucose catabolic process (GO:0006007)2.32067434
129regulation of interferon-beta biosynthetic process (GO:0045357)2.31402576
130protein complex disassembly (GO:0043241)2.30193167
131ribosomal large subunit biogenesis (GO:0042273)2.30165086
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.28680626
133mast cell activation (GO:0045576)2.26314663
134proteasome assembly (GO:0043248)2.26258399
135protein targeting to membrane (GO:0006612)2.23591979
136activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.23535868
137pentose metabolic process (GO:0019321)2.22316019
138positive regulation of interferon-alpha production (GO:0032727)2.22260372
139interferon-gamma-mediated signaling pathway (GO:0060333)2.21093539
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.20738185
141tolerance induction (GO:0002507)2.18796921
142regulation of interleukin-12 biosynthetic process (GO:0045075)2.18784296
143pyrimidine nucleoside salvage (GO:0043097)2.18450416
144pyrimidine-containing compound salvage (GO:0008655)2.18450416
145hepatocyte apoptotic process (GO:0097284)2.17703304
146cellular response to dsRNA (GO:0071359)2.17268465
147regulation of response to interferon-gamma (GO:0060330)2.16878928
148regulation of natural killer cell differentiation (GO:0032823)2.14791949
149T cell migration (GO:0072678)2.13811976
150response to interferon-alpha (GO:0035455)2.12807415
151regulation of superoxide anion generation (GO:0032928)2.12522035
152mature B cell differentiation involved in immune response (GO:0002313)2.11980649
153signal peptide processing (GO:0006465)2.11512607
154macromolecular complex disassembly (GO:0032984)2.11052935
155regulation of necrotic cell death (GO:0010939)2.10857593
156regulation of interferon-alpha production (GO:0032647)2.10325245
157endosome to pigment granule transport (GO:0043485)2.08425745
158endosome to melanosome transport (GO:0035646)2.08425745
159cellular response to virus (GO:0098586)2.07703495
160regulation of RIG-I signaling pathway (GO:0039535)2.07601448
161membrane protein intracellular domain proteolysis (GO:0031293)2.07359429
162regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.06818430
163translation (GO:0006412)2.06211713
164ncRNA 3-end processing (GO:0043628)2.05785145
165negative regulation of viral entry into host cell (GO:0046597)2.05241835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.48740388
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96979386
3E2F7_22180533_ChIP-Seq_HELA_Human2.58713322
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.52833836
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40297862
6* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38223156
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37993119
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32552258
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.28964694
10VDR_21846776_ChIP-Seq_THP-1_Human2.25513426
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23583302
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16621269
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12913433
14RUNX_20019798_ChIP-Seq_JUKART_Human2.11653158
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05699669
16MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99419368
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98202052
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93361157
19MYC_22102868_ChIP-Seq_BL_Human1.92887486
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90533172
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88273910
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.88219874
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87481358
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86581718
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84953277
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.84392763
27SPI1_23547873_ChIP-Seq_NB4_Human1.80052567
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75488289
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74816020
30SPI1_23127762_ChIP-Seq_K562_Human1.74317280
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70587760
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69885705
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68438040
34MAF_26560356_Chip-Seq_TH1_Human1.68419045
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68023384
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65296215
37SCL_19346495_ChIP-Seq_HPC-7_Human1.64358927
38VDR_24763502_ChIP-Seq_THP-1_Human1.62886183
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.60595806
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60536640
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58048158
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.57920990
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57424540
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56640988
45* KDM2B_26808549_Chip-Seq_DND41_Human1.55785062
46* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55245474
47UTX_26944678_Chip-Seq_JUKART_Human1.54787887
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53363553
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.53174821
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.52196360
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52015939
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.51778089
53MYB_26560356_Chip-Seq_TH2_Human1.50830816
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.50529925
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47535132
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45891740
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45495010
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43822280
59MYB_26560356_Chip-Seq_TH1_Human1.41380624
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41358248
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39629628
62VDR_23849224_ChIP-Seq_CD4+_Human1.38431623
63GATA3_27048872_Chip-Seq_THYMUS_Human1.37782358
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.37593461
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35406562
66BCOR_27268052_Chip-Seq_Bcells_Human1.33950289
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.33938617
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32931858
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32744208
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32622025
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32522778
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32444437
73RACK7_27058665_Chip-Seq_MCF-7_Human1.31827923
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30987331
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30856514
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30524511
77XRN2_22483619_ChIP-Seq_HELA_Human1.29966378
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29956878
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27749960
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26867550
81MAF_26560356_Chip-Seq_TH2_Human1.26693278
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25658654
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25156154
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23621410
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23200833
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22803347
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22117764
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21920394
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21068980
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20303764
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.20172813
92GATA1_19941826_ChIP-Seq_K562_Human1.19490437
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19408270
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18387881
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18093303
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17060631
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16065351
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.14844505
99P68_20966046_ChIP-Seq_HELA_Human1.14451239
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14306505
101FOXP3_21729870_ChIP-Seq_TREG_Human1.12860292
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11858500
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11267708
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11224977
105LXR_22292898_ChIP-Seq_THP-1_Human1.09734525
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09393752
107DCP1A_22483619_ChIP-Seq_HELA_Human1.08836809
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08063863
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07946006
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07268558
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.06699190
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.05894191
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05528867
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05310341
115NCOR1_26117541_ChIP-Seq_K562_Human1.05054571
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.03969425
117TCF7_22412390_ChIP-Seq_EML_Mouse1.03651002
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03076483
119BCL6_27268052_Chip-Seq_Bcells_Human1.03066662
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02552966
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01459376
122PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01432259
123NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01280429
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.01171937
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.01152295
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00481755
127GABP_19822575_ChIP-Seq_HepG2_Human1.00083988
128GATA3_26560356_Chip-Seq_TH2_Human0.99948488
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98766108
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98664914
131VDR_24787735_ChIP-Seq_THP-1_Human0.97337490
132GATA1_22025678_ChIP-Seq_K562_Human0.97308520
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97042804
134STAT1_20625510_ChIP-Seq_HELA_Human0.91845077
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90213658
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.90052244
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89388343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.01154666
2MP0000685_abnormal_immune_system2.73632790
3MP0009785_altered_susceptibility_to2.67624042
4MP0003436_decreased_susceptibility_to2.53192796
5MP0005671_abnormal_response_to2.51849944
6MP0009840_abnormal_foam_cell2.46410873
7MP0005360_urolithiasis2.39097443
8* MP0005025_abnormal_response_to2.33979681
9MP0005000_abnormal_immune_tolerance2.31844686
10MP0003806_abnormal_nucleotide_metabolis2.28986839
11* MP0001800_abnormal_humoral_immune2.22097023
12MP0003724_increased_susceptibility_to2.20946273
13MP0010155_abnormal_intestine_physiology2.10805592
14MP0009333_abnormal_splenocyte_physiolog2.10587210
15MP0003763_abnormal_thymus_physiology2.10172437
16MP0001790_abnormal_immune_system2.05137506
17MP0005387_immune_system_phenotype2.05137506
18* MP0002452_abnormal_antigen_presenting2.04840892
19MP0002148_abnormal_hypersensitivity_rea2.04355529
20MP0006082_CNS_inflammation2.03069296
21* MP0002723_abnormal_immune_serum2.01338065
22MP0005464_abnormal_platelet_physiology2.00586924
23MP0003866_abnormal_defecation1.99933240
24MP0002419_abnormal_innate_immunity1.97779918
25* MP0002420_abnormal_adaptive_immunity1.93475301
26* MP0001819_abnormal_immune_cell1.92914476
27MP0002396_abnormal_hematopoietic_system1.92424216
28MP0000490_abnormal_crypts_of1.91845263
29MP0004947_skin_inflammation1.88107161
30MP0001873_stomach_inflammation1.83376901
31MP0004510_myositis1.79732577
32MP0002398_abnormal_bone_marrow1.77600340
33MP0003303_peritoneal_inflammation1.68996072
34MP0002166_altered_tumor_susceptibility1.67047397
35MP0001666_abnormal_nutrient_absorption1.65947397
36MP0000716_abnormal_immune_system1.65765770
37MP0003656_abnormal_erythrocyte_physiolo1.64427422
38MP0005058_abnormal_lysosome_morphology1.61180092
39* MP0001845_abnormal_inflammatory_respons1.60978613
40MP0002405_respiratory_system_inflammati1.60334013
41* MP0000689_abnormal_spleen_morphology1.57839499
42MP0003300_gastrointestinal_ulcer1.56794158
43MP0001853_heart_inflammation1.55909931
44MP0002722_abnormal_immune_system1.55721473
45MP0003191_abnormal_cellular_cholesterol1.54545411
46MP0006054_spinal_hemorrhage1.53005834
47MP0000465_gastrointestinal_hemorrhage1.52522025
48MP0003693_abnormal_embryo_hatching1.51447261
49MP0005397_hematopoietic_system_phenotyp1.49814407
50MP0001545_abnormal_hematopoietic_system1.49814407
51MP0002429_abnormal_blood_cell1.49403014
52* MP0008469_abnormal_protein_level1.49098956
53MP0002132_abnormal_respiratory_system1.48578012
54MP0009278_abnormal_bone_marrow1.48155904
55MP0003075_altered_response_to1.45783758
56MP0002139_abnormal_hepatobiliary_system1.44463990
57MP0000858_altered_metastatic_potential1.36566764
58MP0001533_abnormal_skeleton_physiology1.36004105
59MP0010234_abnormal_vibrissa_follicle1.30918152
60MP0010352_gastrointestinal_tract_polyps1.28972366
61MP0002998_abnormal_bone_remodeling1.28109162
62MP0002006_tumorigenesis1.26846625
63MP0002933_joint_inflammation1.25889936
64MP0005075_abnormal_melanosome_morpholog1.24341023
65MP0008260_abnormal_autophagy1.22321004
66MP0005365_abnormal_bile_salt1.22243715
67MP0000604_amyloidosis1.21717375
68MP0008875_abnormal_xenobiotic_pharmacok1.21577826
69MP0005085_abnormal_gallbladder_physiolo1.20133663
70MP0005166_decreased_susceptibility_to1.18821301
71MP0003183_abnormal_peptide_metabolism1.13849471
72MP0001663_abnormal_digestive_system1.12383266
73MP0003186_abnormal_redox_activity1.11943990
74MP0003172_abnormal_lysosome_physiology1.11798891
75MP0005023_abnormal_wound_healing1.10540114
76MP0000477_abnormal_intestine_morphology1.10108248
77MP0009643_abnormal_urine_homeostasis1.07813638
78MP0000609_abnormal_liver_physiology1.07243317
79MP0000703_abnormal_thymus_morphology1.06420045
80MP0009764_decreased_sensitivity_to1.00418695
81MP0002019_abnormal_tumor_incidence0.97443271
82MP0003566_abnormal_cell_adhesion0.97331231
83MP0005319_abnormal_enzyme/_coenzyme0.96485601
84MP0003828_pulmonary_edema0.94797588
85MP0005164_abnormal_response_to0.94332980
86MP0005310_abnormal_salivary_gland0.93980174
87MP0005451_abnormal_body_composition0.93604504
88MP0005083_abnormal_biliary_tract0.92300703
89MP0009763_increased_sensitivity_to0.91954507
90MP0003453_abnormal_keratinocyte_physiol0.90806688
91MP0008004_abnormal_stomach_pH0.90606125
92MP0004147_increased_porphyrin_level0.90454738
93MP0000343_altered_response_to0.89744282
94MP0009379_abnormal_foot_pigmentation0.88388294
95MP0003279_aneurysm0.87893093
96MP0004808_abnormal_hematopoietic_stem0.87620496
97MP0005584_abnormal_enzyme/coenzyme_acti0.87336920
98MP0001542_abnormal_bone_strength0.86853591
99MP0002277_abnormal_respiratory_mucosa0.85235600
100MP0004957_abnormal_blastocyst_morpholog0.84641508
101MP0005381_digestive/alimentary_phenotyp0.84541027
102MP0005174_abnormal_tail_pigmentation0.83513923
103MP0000598_abnormal_liver_morphology0.83042639
104MP0002138_abnormal_hepatobiliary_system0.82581856
105MP0004381_abnormal_hair_follicle0.81622902
106MP0004883_abnormal_blood_vessel0.81393785
107MP0003690_abnormal_glial_cell0.79677870
108MP0005636_abnormal_mineral_homeostasis0.78876941
109MP0001764_abnormal_homeostasis0.78671948
110MP0003448_altered_tumor_morphology0.77195183
111MP0003795_abnormal_bone_structure0.76461197
112MP0002136_abnormal_kidney_physiology0.76336110
113MP0005165_increased_susceptibility_to0.75772819
114MP0001216_abnormal_epidermal_layer0.74126105
115MP0010329_abnormal_lipoprotein_level0.74102008
116MP0000249_abnormal_blood_vessel0.74041464
117MP0008873_increased_physiological_sensi0.72731632
118MP0003252_abnormal_bile_duct0.71306240
119MP0001243_abnormal_dermal_layer0.71165223
120MP0005390_skeleton_phenotype0.69950987
121MP0001851_eye_inflammation0.69271027
122MP0003045_fibrosis0.65339226
123MP0002877_abnormal_melanocyte_morpholog0.64887938
124MP0009765_abnormal_xenobiotic_induced0.63670081
125MP0003091_abnormal_cell_migration0.63530661
126MP0002332_abnormal_exercise_endurance0.57987835
127* MP0008874_decreased_physiological_sensi0.55956425

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.54067473
2Orchitis (HP:0100796)4.22366272
3Retrobulbar optic neuritis (HP:0100654)3.89269830
4Optic neuritis (HP:0100653)3.89269830
5Eczematoid dermatitis (HP:0000976)3.61253419
6Abnormality of liposaccharide metabolism (HP:0010968)3.57525734
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.57525734
8Abnormality of glycolipid metabolism (HP:0010969)3.57525734
9Petechiae (HP:0000967)3.55808191
10Chronic otitis media (HP:0000389)3.51378474
11Pustule (HP:0200039)3.49235835
12IgM deficiency (HP:0002850)3.43622732
13Recurrent abscess formation (HP:0002722)3.40485985
14Thrombocytosis (HP:0001894)3.34559185
15Pulmonary infiltrates (HP:0002113)3.21506421
16Vacuolated lymphocytes (HP:0001922)3.15606042
17Increased IgM level (HP:0003496)3.14250110
18Recurrent bacterial skin infections (HP:0005406)3.08878840
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.07812029
20Recurrent bronchitis (HP:0002837)3.06603017
21Abnormality of cells of the erythroid lineage (HP:0012130)2.95797114
22Gastrointestinal infarctions (HP:0005244)2.91377448
23Autoimmune thrombocytopenia (HP:0001973)2.90920413
24Myositis (HP:0100614)2.86260819
25Abnormal number of erythroid precursors (HP:0012131)2.84888978
26Encephalitis (HP:0002383)2.83481432
27Abnormality of T cell physiology (HP:0011840)2.83467494
28Systemic lupus erythematosus (HP:0002725)2.80090674
29Keratoconjunctivitis sicca (HP:0001097)2.77177281
30Abnormality of B cell number (HP:0010975)2.76962862
31B lymphocytopenia (HP:0010976)2.76962862
32Recurrent fungal infections (HP:0002841)2.64662297
33Colitis (HP:0002583)2.61004125
34Abnormality of macrophages (HP:0004311)2.59608032
35Abnormality of T cells (HP:0002843)2.56805089
36Hypertensive crisis (HP:0100735)2.55753179
37Interstitial pulmonary disease (HP:0006530)2.55576090
38Loss of speech (HP:0002371)2.55041594
39Gingivitis (HP:0000230)2.53605703
40Increased cerebral lipofuscin (HP:0011813)2.53435189
41Nasal polyposis (HP:0100582)2.53401102
42Recurrent viral infections (HP:0004429)2.52358659
43Keratoconjunctivitis (HP:0001096)2.48763332
44Recurrent skin infections (HP:0001581)2.46180125
45Dysostosis multiplex (HP:0000943)2.42899963
46Cellulitis (HP:0100658)2.40599661
47Combined immunodeficiency (HP:0005387)2.40366997
48Hemoptysis (HP:0002105)2.38963502
49Abnormality of the nasal mucosa (HP:0000433)2.37431160
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37120207
51Purpura (HP:0000979)2.36520392
52Severe combined immunodeficiency (HP:0004430)2.35392352
53Epistaxis (HP:0000421)2.33999376
54Recurrent sinusitis (HP:0011108)2.30592842
55Reticulocytopenia (HP:0001896)2.28991454
56Reduced antithrombin III activity (HP:0001976)2.27661099
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27568186
58Gastrointestinal stroma tumor (HP:0100723)2.26189201
59Episodic fever (HP:0001954)2.25939978
60Increased IgE level (HP:0003212)2.22902538
61Vasculitis (HP:0002633)2.22306130
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21969656
63Spontaneous hematomas (HP:0007420)2.21752071
64Gangrene (HP:0100758)2.19951533
65Increased serum ferritin (HP:0003281)2.19213267
66Amyloidosis (HP:0011034)2.18406526
67Hypergammaglobulinemia (HP:0010702)2.18273500
68Chronic diarrhea (HP:0002028)2.16770867
69Recurrent gram-negative bacterial infections (HP:0005420)2.16399437
70Lymphopenia (HP:0001888)2.15610504
71Nonimmune hydrops fetalis (HP:0001790)2.15562987
72Joint swelling (HP:0001386)2.14881053
73Abnormal platelet function (HP:0011869)2.13054968
74Impaired platelet aggregation (HP:0003540)2.13054968
75Autoimmune hemolytic anemia (HP:0001890)2.13053445
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.12898196
77Chest pain (HP:0100749)2.12028018
78Xanthomatosis (HP:0000991)2.11651586
79Abnormality of the pleura (HP:0002103)2.09314995
80IgG deficiency (HP:0004315)2.08954245
81Verrucae (HP:0200043)2.08304995
82Papilloma (HP:0012740)2.08304995
83Premature loss of primary teeth (HP:0006323)2.07588091
84T lymphocytopenia (HP:0005403)2.07327707
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05871096
86Anorexia (HP:0002039)2.05714665
87Prolonged bleeding time (HP:0003010)2.04796321
88Abnormality of T cell number (HP:0011839)2.04507092
89Urinary glycosaminoglycan excretion (HP:0003541)2.04359753
90Mucopolysacchariduria (HP:0008155)2.04359753
91Stomatitis (HP:0010280)2.04245869
92Arterial thrombosis (HP:0004420)2.03280725
93Macrocytic anemia (HP:0001972)2.03135899
94Gingival bleeding (HP:0000225)2.02542912
95Emphysema (HP:0002097)2.02274343
96Meningitis (HP:0001287)2.01704456
97Gastrointestinal inflammation (HP:0004386)2.01451466
98Granulocytopenia (HP:0001913)2.00982266
99Pulmonary embolism (HP:0002204)2.00605028
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00020868
101Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00020868
102Exertional dyspnea (HP:0002875)1.97802999
103Leukocytosis (HP:0001974)1.97329487
104Glomerulopathy (HP:0100820)1.96464992
105Urticaria (HP:0001025)1.96261284
106Recurrent pneumonia (HP:0006532)1.96232549
107Restrictive lung disease (HP:0002091)1.95548979
108Pallor (HP:0000980)1.95001791
109Agammaglobulinemia (HP:0004432)1.94345623
110Abnormal platelet volume (HP:0011876)1.93744832
111Increased muscle lipid content (HP:0009058)1.93571557
112Vertebral compression fractures (HP:0002953)1.93525131
113Skin ulcer (HP:0200042)1.92215635
114Abnormality of eosinophils (HP:0001879)1.92023561
115Abnormality of iron homeostasis (HP:0011031)1.91951337
116Aplastic anemia (HP:0001915)1.91332931
117Inflammation of the large intestine (HP:0002037)1.91092991
118Increased intramyocellular lipid droplets (HP:0012240)1.90314644
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.89926765
120Chronic obstructive pulmonary disease (HP:0006510)1.88022744
121Obstructive lung disease (HP:0006536)1.88022744
122Panhypogammaglobulinemia (HP:0003139)1.87487430
123Hepatosplenomegaly (HP:0001433)1.86595499
124Skin rash (HP:0000988)1.85744751
125Poikiloderma (HP:0001029)1.84954749
126Eosinophilia (HP:0001880)1.83969164
127Ileus (HP:0002595)1.83358268
128Periodontitis (HP:0000704)1.82394104
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81801270
130Abnormality of polysaccharide metabolism (HP:0011012)1.81801270
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81801270
132Gastrointestinal dysmotility (HP:0002579)1.81674457
133Chronic mucocutaneous candidiasis (HP:0002728)1.80025031
134Recurrent cutaneous fungal infections (HP:0011370)1.80025031
135Abnormality of transition element cation homeostasis (HP:0011030)1.79715765
136Mediastinal lymphadenopathy (HP:0100721)1.77830768
137Beaking of vertebral bodies (HP:0004568)1.77770706
138Erythema (HP:0010783)1.76571781
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.74094182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.41003224
2TAOK33.19989172
3BLK3.12877514
4NME22.98814470
5PIM22.84583498
6TESK22.72455184
7TBK12.67861131
8ERN12.34366201
9PRPF4B2.32605409
10KDR2.12223802
11TYK22.10864670
12ZAP702.00161913
13JAK31.89814272
14STK101.79762973
15LRRK21.78445182
16IKBKE1.78014648
17FGFR41.72462890
18EIF2AK11.71997239
19STK161.68676522
20KIT1.68502124
21MST41.67828855
22TAOK21.62903345
23BTK1.58048206
24GRK61.51008840
25TXK1.50475700
26MAP3K141.46319688
27GRK71.43835712
28MAP3K131.40427757
29IRAK41.38034652
30TESK11.36304408
31EPHB11.35229869
32TEC1.33355480
33EEF2K1.31672177
34TRIB31.30617740
35IKBKB1.30578943
36MST1R1.25614619
37PKN21.23592838
38NLK1.21486678
39MAP2K21.21416794
40TLK11.19958708
41CSF1R1.16418724
42RIPK11.15997266
43SYK1.15684985
44FLT31.14357210
45CSK1.13364740
46MAP3K101.12993888
47TGFBR21.12600662
48EIF2AK31.11757773
49ITK1.09654124
50SMG11.08989826
51MAP3K111.07586409
52BCKDK1.07027024
53LCK1.03665152
54CDC42BPA0.99759287
55SCYL20.99462425
56PRKG20.97711845
57SIK10.96696310
58RPS6KA40.96572477
59IRAK30.96357602
60MAP3K80.95179026
61BUB10.93858276
62BMPR20.93435051
63PRKD20.92378540
64MATK0.92349259
65MAP2K30.89303595
66LYN0.88961049
67RPS6KB20.88802289
68PIM10.88094988
69FGR0.86734577
70LIMK10.85697916
71MOS0.84766203
72SIK30.82204727
73JAK10.80365758
74ARAF0.79137734
75WEE10.78297179
76FES0.77849193
77HIPK20.74918340
78ILK0.73031826
79PAK40.72959333
80HCK0.65122513
81EPHA30.64961747
82IRAK20.62933413
83MAP3K30.59913653
84CLK10.59700782
85DAPK30.58882263
86MAPK110.57948695
87PTK60.57429411
88MAPKAPK30.57084818
89PDK10.56587359
90TAOK10.55695518
91PDPK10.54821885
92MAPK70.54039365
93JAK20.53874775
94PAK10.52715575
95TNK20.50842740
96MAP2K60.49130181
97MAPK120.49014663
98MYLK0.48723530
99MAPK40.48626402
100MAPKAPK20.48542928
101FYN0.48341035
102BMX0.46573152
103PBK0.45700101
104TGFBR10.45252677
105MARK20.44231895
106ABL20.43914560
107MAP3K70.43618533
108SIK20.43284601
109MAPKAPK50.43224373
110RPS6KL10.42786974
111RPS6KC10.42786974
112CHUK0.41855756
113GRK50.41077146
114MAP3K60.40597709
115CDK40.40240902
116DDR20.39595565
117IRAK10.37760948
118PIK3CG0.36293853
119TRPM70.36032565
120MAPK150.35419640
121NEK20.35050543
122PRKCQ0.35020761
123PRKCD0.35007798
124RPS6KA50.34177798
125DYRK30.34092946
126CAMKK10.33780019
127RPS6KA60.32702829
128MAP3K50.31891716
129DYRK1B0.31676109
130ADRBK20.31255430
131MET0.29515655
132RIPK40.28985383
133MARK30.28231447
134MAP3K10.27668756

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.01940566
2Autoimmune thyroid disease_Homo sapiens_hsa053202.92293965
3Primary immunodeficiency_Homo sapiens_hsa053402.62537978
4Type I diabetes mellitus_Homo sapiens_hsa049402.16818779
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10653015
6Folate biosynthesis_Homo sapiens_hsa007902.07883235
7Proteasome_Homo sapiens_hsa030501.98198548
8DNA replication_Homo sapiens_hsa030301.84254407
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.82441276
10Rheumatoid arthritis_Homo sapiens_hsa053231.81946730
11Sulfur relay system_Homo sapiens_hsa041221.81930689
12Caffeine metabolism_Homo sapiens_hsa002321.78465002
13Viral myocarditis_Homo sapiens_hsa054161.73566636
14Pentose phosphate pathway_Homo sapiens_hsa000301.72960833
15* TNF signaling pathway_Homo sapiens_hsa046681.69221525
16Other glycan degradation_Homo sapiens_hsa005111.62073002
17Leishmaniasis_Homo sapiens_hsa051401.59370603
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55588099
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.50180248
20Measles_Homo sapiens_hsa051621.46648149
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45619278
22Antigen processing and presentation_Homo sapiens_hsa046121.43918324
23Sulfur metabolism_Homo sapiens_hsa009201.39725524
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35797966
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32034157
26Hematopoietic cell lineage_Homo sapiens_hsa046401.31438972
27African trypanosomiasis_Homo sapiens_hsa051431.29303525
28Chemokine signaling pathway_Homo sapiens_hsa040621.28754035
29* NF-kappa B signaling pathway_Homo sapiens_hsa040641.27017967
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26060631
31Pyrimidine metabolism_Homo sapiens_hsa002401.23833479
32Staphylococcus aureus infection_Homo sapiens_hsa051501.21927269
33Shigellosis_Homo sapiens_hsa051311.19658967
34Legionellosis_Homo sapiens_hsa051341.19118070
35Histidine metabolism_Homo sapiens_hsa003401.17153001
36Protein export_Homo sapiens_hsa030601.14088845
37B cell receptor signaling pathway_Homo sapiens_hsa046621.13845583
38* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13670588
39Fat digestion and absorption_Homo sapiens_hsa049751.11912419
40Mismatch repair_Homo sapiens_hsa034301.10337032
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09746225
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08746434
43Base excision repair_Homo sapiens_hsa034101.06687655
44Allograft rejection_Homo sapiens_hsa053301.05648438
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05204303
46RNA polymerase_Homo sapiens_hsa030201.04912463
47Pertussis_Homo sapiens_hsa051331.04493788
48Herpes simplex infection_Homo sapiens_hsa051681.03425001
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97780814
50Phagosome_Homo sapiens_hsa041450.96451593
51Osteoclast differentiation_Homo sapiens_hsa043800.95755868
52Glutathione metabolism_Homo sapiens_hsa004800.95505735
53T cell receptor signaling pathway_Homo sapiens_hsa046600.95286001
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94489879
55Galactose metabolism_Homo sapiens_hsa000520.94077656
56Selenocompound metabolism_Homo sapiens_hsa004500.93606332
57Malaria_Homo sapiens_hsa051440.93512484
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92778433
59* Apoptosis_Homo sapiens_hsa042100.90905517
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90709655
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.89836379
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.88870496
63Steroid biosynthesis_Homo sapiens_hsa001000.88180093
64Lysosome_Homo sapiens_hsa041420.85782876
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84889432
66Acute myeloid leukemia_Homo sapiens_hsa052210.83351455
67One carbon pool by folate_Homo sapiens_hsa006700.81983636
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.80597183
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.79702043
70Vitamin digestion and absorption_Homo sapiens_hsa049770.78806770
71VEGF signaling pathway_Homo sapiens_hsa043700.78663440
72Renin-angiotensin system_Homo sapiens_hsa046140.77606949
73Toxoplasmosis_Homo sapiens_hsa051450.76845127
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75876396
75Influenza A_Homo sapiens_hsa051640.74378247
76Salmonella infection_Homo sapiens_hsa051320.74119137
77p53 signaling pathway_Homo sapiens_hsa041150.72139322
78Spliceosome_Homo sapiens_hsa030400.71829989
79Graft-versus-host disease_Homo sapiens_hsa053320.71683843
80Tryptophan metabolism_Homo sapiens_hsa003800.71570333
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.71446313
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70690999
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70113332
84Nucleotide excision repair_Homo sapiens_hsa034200.70018549
85Asthma_Homo sapiens_hsa053100.69581751
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68469288
87Endocytosis_Homo sapiens_hsa041440.68439480
88HTLV-I infection_Homo sapiens_hsa051660.68383224
89Fatty acid degradation_Homo sapiens_hsa000710.68140819
90* Hepatitis C_Homo sapiens_hsa051600.66406207
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66354035
92Chemical carcinogenesis_Homo sapiens_hsa052040.65862611
93Hepatitis B_Homo sapiens_hsa051610.65744797
94Homologous recombination_Homo sapiens_hsa034400.64303872
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64263014
96Prion diseases_Homo sapiens_hsa050200.63678465
97Peroxisome_Homo sapiens_hsa041460.63503523
98Platelet activation_Homo sapiens_hsa046110.61972910
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61565167
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61465384
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59138336
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58302592
103Fructose and mannose metabolism_Homo sapiens_hsa000510.58296888
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58222895
105N-Glycan biosynthesis_Homo sapiens_hsa005100.57730400
106Chronic myeloid leukemia_Homo sapiens_hsa052200.57697755
107Non-small cell lung cancer_Homo sapiens_hsa052230.57629170
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57311543
109Systemic lupus erythematosus_Homo sapiens_hsa053220.57221885
110* Adipocytokine signaling pathway_Homo sapiens_hsa049200.56689627
111* Epstein-Barr virus infection_Homo sapiens_hsa051690.56453007
112* Tuberculosis_Homo sapiens_hsa051520.55933801
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55549198
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55500982
115Pancreatic cancer_Homo sapiens_hsa052120.54693548
116Complement and coagulation cascades_Homo sapiens_hsa046100.54149981
117Carbon metabolism_Homo sapiens_hsa012000.51886456
118* Viral carcinogenesis_Homo sapiens_hsa052030.51675324
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51651016
120Biosynthesis of amino acids_Homo sapiens_hsa012300.51214078
121Bladder cancer_Homo sapiens_hsa052190.50138600
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49970456
123Starch and sucrose metabolism_Homo sapiens_hsa005000.48921298
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48903662
125Prolactin signaling pathway_Homo sapiens_hsa049170.48330150
126Amoebiasis_Homo sapiens_hsa051460.47973380
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43429411
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43106867
129* Sphingolipid signaling pathway_Homo sapiens_hsa040710.42308488
130Notch signaling pathway_Homo sapiens_hsa043300.42056662
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.41253383
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.27741100
133Arachidonic acid metabolism_Homo sapiens_hsa005900.27487698
134Insulin resistance_Homo sapiens_hsa049310.27025949
135MAPK signaling pathway_Homo sapiens_hsa040100.25876748
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25748873
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22456901
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.18063520
139Sphingolipid metabolism_Homo sapiens_hsa006000.16756632
140Small cell lung cancer_Homo sapiens_hsa052220.16358588
141Renal cell carcinoma_Homo sapiens_hsa052110.15504760
142Phenylalanine metabolism_Homo sapiens_hsa003600.14408769
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13865765
144HIF-1 signaling pathway_Homo sapiens_hsa040660.13015284
145FoxO signaling pathway_Homo sapiens_hsa040680.11458009
146mTOR signaling pathway_Homo sapiens_hsa041500.10702532

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