TRA2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)4.91164020
2DNA double-strand break processing (GO:0000729)4.84925089
3DNA deamination (GO:0045006)4.39188890
4mitotic sister chromatid cohesion (GO:0007064)4.26388043
5pre-miRNA processing (GO:0031054)4.16855454
6nuclear pore complex assembly (GO:0051292)4.00977372
7nuclear pore organization (GO:0006999)4.00614429
8regulation of RNA export from nucleus (GO:0046831)3.82082394
9DNA unwinding involved in DNA replication (GO:0006268)3.81332068
10protein localization to kinetochore (GO:0034501)3.70090344
11negative regulation of histone methylation (GO:0031061)3.68819525
12replication fork processing (GO:0031297)3.64246622
13regulation of histone H3-K9 methylation (GO:0051570)3.55449966
14respiratory chain complex IV assembly (GO:0008535)3.55298315
15mRNA splice site selection (GO:0006376)3.53461537
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52841898
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51642275
18regulation of meiosis I (GO:0060631)3.49865772
19response to pheromone (GO:0019236)3.49474400
20kidney morphogenesis (GO:0060993)3.41845162
21limb bud formation (GO:0060174)3.39849794
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39708618
23negative regulation of mRNA processing (GO:0050686)3.38054681
24negative regulation of RNA splicing (GO:0033119)3.32314675
25L-fucose catabolic process (GO:0042355)3.29977703
26fucose catabolic process (GO:0019317)3.29977703
27L-fucose metabolic process (GO:0042354)3.29977703
28lactate metabolic process (GO:0006089)3.28054158
29platelet dense granule organization (GO:0060155)3.26443905
30neural tube formation (GO:0001841)3.26061825
31protein K11-linked deubiquitination (GO:0035871)3.22843635
32axoneme assembly (GO:0035082)3.22336315
33protein localization to chromosome, centromeric region (GO:0071459)3.19738401
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.17934280
35regulation of translation, ncRNA-mediated (GO:0045974)3.17934280
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17934280
37alternative mRNA splicing, via spliceosome (GO:0000380)3.17328054
38sister chromatid segregation (GO:0000819)3.16282652
39regulation of histone H3-K27 methylation (GO:0061085)3.14034114
40mitotic metaphase plate congression (GO:0007080)3.13907165
41dosage compensation (GO:0007549)3.12692232
42cytochrome complex assembly (GO:0017004)3.12283823
43regulation of sister chromatid cohesion (GO:0007063)3.12265358
44regulation of DNA endoreduplication (GO:0032875)3.11008802
45protein prenylation (GO:0018342)3.10840826
46prenylation (GO:0097354)3.10840826
47cornea development in camera-type eye (GO:0061303)3.09232772
48regulation of centriole replication (GO:0046599)3.09123159
49regulation of hexokinase activity (GO:1903299)3.06333026
50regulation of glucokinase activity (GO:0033131)3.06333026
51regulation of helicase activity (GO:0051095)3.06324147
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05423729
53isotype switching (GO:0045190)3.05423729
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05423729
55tryptophan catabolic process (GO:0006569)3.05185483
56indole-containing compound catabolic process (GO:0042436)3.05185483
57indolalkylamine catabolic process (GO:0046218)3.05185483
58histone H3-K4 trimethylation (GO:0080182)3.05172947
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02561743
60DNA geometric change (GO:0032392)3.01279159
61DNA duplex unwinding (GO:0032508)3.01099059
62proteasome assembly (GO:0043248)2.98160302
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97486268
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97463069
65negative regulation of mRNA metabolic process (GO:1903312)2.97387119
66positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.97240203
67regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.97240203
68atrial cardiac muscle cell action potential (GO:0086014)2.95558861
69regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.95032851
70recombinational repair (GO:0000725)2.91737021
71double-strand break repair via homologous recombination (GO:0000724)2.90908161
72histone H2A acetylation (GO:0043968)2.90472058
73pore complex assembly (GO:0046931)2.90400695
74DNA replication-dependent nucleosome assembly (GO:0006335)2.89751308
75DNA replication-dependent nucleosome organization (GO:0034723)2.89751308
76mitotic nuclear envelope disassembly (GO:0007077)2.89092483
77water-soluble vitamin biosynthetic process (GO:0042364)2.88694170
78metaphase plate congression (GO:0051310)2.88624079
79regulation of nucleobase-containing compound transport (GO:0032239)2.88454147
80positive regulation of chromosome segregation (GO:0051984)2.87989448
81kinetochore organization (GO:0051383)2.87207413
82paraxial mesoderm development (GO:0048339)2.86462934
83DNA topological change (GO:0006265)2.86435798
84mitotic sister chromatid segregation (GO:0000070)2.86057093
85tryptophan metabolic process (GO:0006568)2.85889675
86chromatin assembly (GO:0031497)2.85853001
87detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84977390
88positive regulation of mRNA catabolic process (GO:0061014)2.84122811
89regulation of histone methylation (GO:0031060)2.83890344
90positive regulation of glycoprotein biosynthetic process (GO:0010560)2.83536107
91inositol phosphate catabolic process (GO:0071545)2.82565856
92mitotic chromosome condensation (GO:0007076)2.81153101
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79867846
94regulation of mitotic spindle checkpoint (GO:1903504)2.79867846
95negative regulation of JUN kinase activity (GO:0043508)2.79655747
96peptidyl-lysine trimethylation (GO:0018023)2.79514884
97indolalkylamine metabolic process (GO:0006586)2.79264631
98negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78896681
99positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.77730011
100regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.77730011
101nuclear envelope disassembly (GO:0051081)2.77173514
102membrane disassembly (GO:0030397)2.77173514
103positive regulation of histone H3-K4 methylation (GO:0051571)2.75550511
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74486297
105protein localization to chromosome (GO:0034502)2.73090705
106mRNA stabilization (GO:0048255)2.72880577
107RNA stabilization (GO:0043489)2.72880577
108S-adenosylmethionine metabolic process (GO:0046500)2.72711100
109regulation of gene silencing by RNA (GO:0060966)2.72048191
110regulation of posttranscriptional gene silencing (GO:0060147)2.72048191
111regulation of gene silencing by miRNA (GO:0060964)2.72048191
112kynurenine metabolic process (GO:0070189)2.70488581
113positive regulation of mRNA processing (GO:0050685)2.70386132
114regulation of telomere maintenance via telomerase (GO:0032210)2.70188090
115synapsis (GO:0007129)2.69977513
116regulation of spindle organization (GO:0090224)2.69876068
117regulation of centrosome cycle (GO:0046605)2.69166120
118ribosome assembly (GO:0042255)2.68765781
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68126725
120presynaptic membrane assembly (GO:0097105)2.67108704
121positive regulation of mRNA metabolic process (GO:1903313)2.66949802
122glial cell proliferation (GO:0014009)2.66925446
123histone H3-K4 methylation (GO:0051568)2.65726633
124histone H2A monoubiquitination (GO:0035518)2.65611283
125prostate gland growth (GO:0060736)2.65295487
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.64240975
127* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64110405
128* mRNA splicing, via spliceosome (GO:0000398)2.64110405
129regulation of DNA damage checkpoint (GO:2000001)2.61899949
130DNA catabolic process, exonucleolytic (GO:0000738)2.61816667
131polyol catabolic process (GO:0046174)2.61488912
132* RNA splicing, via transesterification reactions (GO:0000375)2.61164381
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.59981569
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.59981569
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.59981569
136magnesium ion transport (GO:0015693)2.59529651
137chromatin assembly or disassembly (GO:0006333)2.59481810
138positive regulation of histone methylation (GO:0031062)2.59144188
139ATP-dependent chromatin remodeling (GO:0043044)2.59046959
140protein complex biogenesis (GO:0070271)2.58485678
141mRNA transport (GO:0051028)2.58029695
142regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.57532260
143histone H2A ubiquitination (GO:0033522)2.57071740
144preassembly of GPI anchor in ER membrane (GO:0016254)2.56674306
145termination of RNA polymerase II transcription (GO:0006369)2.56287614
146heterochromatin organization (GO:0070828)2.55737490
147regulation of mRNA stability (GO:0043488)2.54208430
148DNA replication-independent nucleosome organization (GO:0034724)2.52990882
149DNA replication-independent nucleosome assembly (GO:0006336)2.52990882
150signal peptide processing (GO:0006465)2.52697763
151positive regulation of protein autophosphorylation (GO:0031954)2.52171137
152regulation of histone H3-K4 methylation (GO:0051569)2.51369662
153protein localization to cilium (GO:0061512)2.50938174
154regulation of centrosome duplication (GO:0010824)2.50883480
155embryonic epithelial tube formation (GO:0001838)2.50773002
156cytoplasmic mRNA processing body assembly (GO:0033962)2.50709331
157regulation of mRNA 3-end processing (GO:0031440)2.50108929
158RNA export from nucleus (GO:0006405)2.49791851
159negative regulation of DNA repair (GO:0045738)2.49244374
160protein K6-linked ubiquitination (GO:0085020)2.48889410
161rRNA catabolic process (GO:0016075)2.48208482
162positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.48135653
163mitochondrial respiratory chain complex assembly (GO:0033108)2.47093547
164regulation of cilium movement (GO:0003352)2.46342192
165DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46025933
166regulation of chromosome segregation (GO:0051983)2.45940135
167mRNA export from nucleus (GO:0006406)2.45536760
168histone H3-K9 methylation (GO:0051567)2.44996693
169regulation of telomere maintenance (GO:0032204)2.44490685
170DNA conformation change (GO:0071103)2.43780957
171epithelial cilium movement (GO:0003351)2.43561288
172somatic hypermutation of immunoglobulin genes (GO:0016446)2.43317708
173somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43317708
174cilium morphogenesis (GO:0060271)2.43067920
175spindle checkpoint (GO:0031577)2.43026883
176sympathetic nervous system development (GO:0048485)2.42705296
177somite development (GO:0061053)2.41740190
178centriole replication (GO:0007099)2.41368124
179establishment of chromosome localization (GO:0051303)2.41362771
180hindbrain development (GO:0030902)2.41028742
181positive regulation of mRNA 3-end processing (GO:0031442)2.40985097
182retinal cone cell development (GO:0046549)2.40899220
183adenosine metabolic process (GO:0046085)2.40848296
184DNA replication initiation (GO:0006270)2.40610902
185RNA destabilization (GO:0050779)2.40595504
186regulation of chromatin binding (GO:0035561)2.39970991
187histone H4-K16 acetylation (GO:0043984)2.39619737
188mitotic spindle checkpoint (GO:0071174)2.39500949
189regulation of nuclear cell cycle DNA replication (GO:0033262)2.39455548
190nucleic acid transport (GO:0050657)2.39242771
191establishment of RNA localization (GO:0051236)2.39242771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.52772118
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.60439208
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.31614301
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31071470
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.77035495
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.30000113
7ZNF274_21170338_ChIP-Seq_K562_Hela3.21807493
8VDR_22108803_ChIP-Seq_LS180_Human3.03550671
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.97533713
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95516950
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90521645
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.75335157
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64473881
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52205942
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.51646322
16IGF1R_20145208_ChIP-Seq_DFB_Human2.45538509
17GBX2_23144817_ChIP-Seq_PC3_Human2.41077563
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37702042
19MYC_22102868_ChIP-Seq_BL_Human2.34428901
20TAF15_26573619_Chip-Seq_HEK293_Human2.33228540
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30989829
22P300_19829295_ChIP-Seq_ESCs_Human2.30053774
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.28217100
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26826608
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17940370
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06591883
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06591883
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06591883
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03893596
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.01013517
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.95727689
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93660493
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92447296
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90725482
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90376796
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89785757
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88834953
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85766589
39CIITA_25753668_ChIP-Seq_RAJI_Human1.85330500
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79809595
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79382695
42AR_21909140_ChIP-Seq_LNCAP_Human1.79091688
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77590011
44* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75724183
45ER_23166858_ChIP-Seq_MCF-7_Human1.75234147
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67117420
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66606034
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63794080
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63750389
50BCAT_22108803_ChIP-Seq_LS180_Human1.62364973
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.61941967
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.61919511
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60354230
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59732262
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59326709
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58394913
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56035107
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55932126
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54624031
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.53443348
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50242211
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.49967216
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49776650
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49405063
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48613909
66CBP_20019798_ChIP-Seq_JUKART_Human1.48613909
67* XRN2_22483619_ChIP-Seq_HELA_Human1.48398229
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48338102
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48312966
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47442120
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46156336
72MYC_18940864_ChIP-ChIP_HL60_Human1.44804386
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43219870
74AR_25329375_ChIP-Seq_VCAP_Human1.43180284
75SMAD4_21799915_ChIP-Seq_A2780_Human1.42767034
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42563492
77NANOG_19829295_ChIP-Seq_ESCs_Human1.42280360
78SOX2_19829295_ChIP-Seq_ESCs_Human1.42280360
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.41823141
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40952722
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38732143
82TTF2_22483619_ChIP-Seq_HELA_Human1.37895834
83TCF4_22108803_ChIP-Seq_LS180_Human1.36226526
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35676579
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35451100
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.35095923
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33240671
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33240477
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33059022
90STAT3_23295773_ChIP-Seq_U87_Human1.32207741
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31207442
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30888113
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30112797
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29919115
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29546440
96* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28645711
97* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28541525
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.26378619
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26241707
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25335457
101ELK1_19687146_ChIP-ChIP_HELA_Human1.25233901
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24719164
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23814745
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23519951
105CDX2_22108803_ChIP-Seq_LS180_Human1.23395885
106KDM5A_27292631_Chip-Seq_BREAST_Human1.23223503
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23002161
108VDR_23849224_ChIP-Seq_CD4+_Human1.22853387
109TCF4_23295773_ChIP-Seq_U87_Human1.22600503
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22378762
111P53_22387025_ChIP-Seq_ESCs_Mouse1.22148437
112* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21647212
113* SOX2_16153702_ChIP-ChIP_HESCs_Human1.21073075
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20524567
115TP53_22573176_ChIP-Seq_HFKS_Human1.20253950
116IRF1_19129219_ChIP-ChIP_H3396_Human1.19947300
117TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19013731
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.18419149
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17933901
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17571998
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17571998
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17433464
123RUNX2_22187159_ChIP-Seq_PCA_Human1.17074595
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16046884
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15701917
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.15681423
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14487424
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12417237
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.12417237
130POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12072017
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11800670
132TCF7_22412390_ChIP-Seq_EML_Mouse1.11193074
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10649784
134* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10366370
135RNF2_27304074_Chip-Seq_NSC_Mouse1.09961760
136EWS_26573619_Chip-Seq_HEK293_Human1.09465039
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08880773
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.08555026
139P300_18555785_Chip-Seq_ESCs_Mouse1.07965879
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.06900183
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06496487
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05935741
143VDR_21846776_ChIP-Seq_THP-1_Human1.05906959
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.05647695
145OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05279014
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03786591
147FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03631339
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03187365
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.02495746
150PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02037349
151* CHD1_26751641_Chip-Seq_LNCaP_Human1.01788422
152PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01519683
153SMAD_19615063_ChIP-ChIP_OVARY_Human1.01487407
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.99305808
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98403458
156EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98397142
157TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97297419
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97181799
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94795608
160KDM2B_26808549_Chip-Seq_DND41_Human0.94241684
161TFEB_21752829_ChIP-Seq_HELA_Human0.93072501
162FOXP3_21729870_ChIP-Seq_TREG_Human0.92091889
163FUS_26573619_Chip-Seq_HEK293_Human0.91911956
164KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91498051
165ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87837717
166* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86259197
167* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86202605
168* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85787591
169* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85409647
170NANOG_16153702_ChIP-ChIP_HESCs_Human0.85276126
171EST1_17652178_ChIP-ChIP_JURKAT_Human0.84533592
172* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83426792
173ETS1_20019798_ChIP-Seq_JURKAT_Human0.82470845
174NOTCH1_21737748_ChIP-Seq_TLL_Human0.80812578
175POU5F1_16518401_ChIP-PET_MESCs_Mouse0.80395491
176ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79772864
177WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79171919
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78861805
179E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78646301
180EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77204236
181TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76824949
182* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76404599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.73280957
2MP0010094_abnormal_chromosome_stability3.28907227
3MP0003195_calcinosis3.17520719
4MP0003111_abnormal_nucleus_morphology3.08613291
5MP0003693_abnormal_embryo_hatching3.08049520
6MP0002102_abnormal_ear_morphology2.87456824
7MP0003077_abnormal_cell_cycle2.61159025
8MP0004957_abnormal_blastocyst_morpholog2.40158733
9MP0003121_genomic_imprinting2.11551595
10MP0003123_paternal_imprinting2.10999386
11MP0008995_early_reproductive_senescence2.10609266
12MP0008058_abnormal_DNA_repair2.09394882
13MP0000537_abnormal_urethra_morphology1.99373494
14MP0000372_irregular_coat_pigmentation1.97892433
15MP0003787_abnormal_imprinting1.94558921
16MP0010352_gastrointestinal_tract_polyps1.93285945
17MP0005551_abnormal_eye_electrophysiolog1.91376761
18MP0005076_abnormal_cell_differentiation1.87401988
19MP0005253_abnormal_eye_physiology1.85850019
20MP0000350_abnormal_cell_proliferation1.84334348
21MP0002837_dystrophic_cardiac_calcinosis1.79067538
22MP0001293_anophthalmia1.77561418
23MP0000427_abnormal_hair_cycle1.75125656
24MP0008007_abnormal_cellular_replicative1.74623503
25MP0002084_abnormal_developmental_patter1.74537338
26MP0001984_abnormal_olfaction1.72441486
27MP0010307_abnormal_tumor_latency1.70473097
28MP0000569_abnormal_digit_pigmentation1.69591735
29MP0004197_abnormal_fetal_growth/weight/1.69389904
30MP0008872_abnormal_physiological_respon1.64209176
31MP0002085_abnormal_embryonic_tissue1.61854590
32MP0005646_abnormal_pituitary_gland1.61792951
33MP0001730_embryonic_growth_arrest1.61338501
34MP0008932_abnormal_embryonic_tissue1.60694886
35MP0008877_abnormal_DNA_methylation1.60176092
36MP0005084_abnormal_gallbladder_morpholo1.59187428
37MP0005645_abnormal_hypothalamus_physiol1.57171788
38MP0001672_abnormal_embryogenesis/_devel1.56818658
39MP0005380_embryogenesis_phenotype1.56818658
40MP0002736_abnormal_nociception_after1.55986309
41MP0000631_abnormal_neuroendocrine_gland1.54603196
42MP0002653_abnormal_ependyma_morphology1.54476669
43MP0003937_abnormal_limbs/digits/tail_de1.52623113
44MP0003941_abnormal_skin_development1.52055715
45MP0003718_maternal_effect1.50164363
46MP0003890_abnormal_embryonic-extraembry1.48585044
47MP0003880_abnormal_central_pattern1.48471526
48MP0002396_abnormal_hematopoietic_system1.46781067
49MP0002751_abnormal_autonomic_nervous1.46355750
50MP0000383_abnormal_hair_follicle1.44708923
51MP0010030_abnormal_orbit_morphology1.44199649
52MP0002138_abnormal_hepatobiliary_system1.43259451
53MP0003984_embryonic_growth_retardation1.42988272
54MP0003567_abnormal_fetal_cardiomyocyte1.42740654
55MP0002088_abnormal_embryonic_growth/wei1.42382737
56MP0009046_muscle_twitch1.41848041
57MP0003136_yellow_coat_color1.41160525
58MP0004808_abnormal_hematopoietic_stem1.40608908
59MP0001697_abnormal_embryo_size1.40481900
60MP0002254_reproductive_system_inflammat1.40175613
61MP0001968_abnormal_touch/_nociception1.38937203
62MP0001188_hyperpigmentation1.38839138
63MP0002086_abnormal_extraembryonic_tissu1.37840868
64MP0002638_abnormal_pupillary_reflex1.37400126
65MP0009278_abnormal_bone_marrow1.36231834
66MP0000647_abnormal_sebaceous_gland1.33733749
67MP0005389_reproductive_system_phenotype1.33270136
68MP0010678_abnormal_skin_adnexa1.32746279
69MP0005379_endocrine/exocrine_gland_phen1.32592554
70MP0001485_abnormal_pinna_reflex1.31729292
71MP0002163_abnormal_gland_morphology1.30624118
72MP0000428_abnormal_craniofacial_morphol1.27930352
73MP0006072_abnormal_retinal_apoptosis1.27679393
74MP0006054_spinal_hemorrhage1.24827274
75MP0006292_abnormal_olfactory_placode1.23868533
76MP0010234_abnormal_vibrissa_follicle1.22681837
77MP0003119_abnormal_digestive_system1.21850760
78MP0005075_abnormal_melanosome_morpholog1.21379541
79MP0002009_preneoplasia1.19232985
80MP0001986_abnormal_taste_sensitivity1.19107752
81MP0000733_abnormal_muscle_development1.18872319
82MP0002080_prenatal_lethality1.18816719
83MP0004215_abnormal_myocardial_fiber1.18150451
84MP0003935_abnormal_craniofacial_develop1.17650942
85MP0009703_decreased_birth_body1.17332860
86MP0002277_abnormal_respiratory_mucosa1.16696815
87MP0003861_abnormal_nervous_system1.16534486
88MP0002092_abnormal_eye_morphology1.15230367
89MP0005220_abnormal_exocrine_pancreas1.13919422
90MP0002938_white_spotting1.13879522
91MP0001919_abnormal_reproductive_system1.12266918
92MP0002160_abnormal_reproductive_system1.11810269
93MP0001286_abnormal_eye_development1.11083438
94MP0001486_abnormal_startle_reflex1.10663410
95MP0000432_abnormal_head_morphology1.10209215
96MP0000613_abnormal_salivary_gland1.09765763
97MP0002876_abnormal_thyroid_physiology1.09400257
98MP0009745_abnormal_behavioral_response1.09373574
99MP0003283_abnormal_digestive_organ1.08888555
100MP0002234_abnormal_pharynx_morphology1.08851785
101MP0004043_abnormal_pH_regulation1.07944172
102MP0002697_abnormal_eye_size1.05672607
103MP0001929_abnormal_gametogenesis1.05110126
104MP0009697_abnormal_copulation1.04963181
105MP0001501_abnormal_sleep_pattern1.04709723
106MP0002557_abnormal_social/conspecific_i1.03705356
107MP0004147_increased_porphyrin_level1.03543893
108MP0004133_heterotaxia1.02873075
109MP0002090_abnormal_vision1.02390618
110MP0002928_abnormal_bile_duct1.01711852
111MP0000653_abnormal_sex_gland1.01016081
112MP0003755_abnormal_palate_morphology1.00166545
113MP0009053_abnormal_anal_canal0.98481825
114MP0008789_abnormal_olfactory_epithelium0.97661980
115MP0002166_altered_tumor_susceptibility0.97512524
116MP0003938_abnormal_ear_development0.97023192
117MP0000703_abnormal_thymus_morphology0.96478936
118MP0000490_abnormal_crypts_of0.96045154
119MP0002111_abnormal_tail_morphology0.95261689
120MP0003786_premature_aging0.92773228
121MP0009672_abnormal_birth_weight0.92380047
122MP0000313_abnormal_cell_death0.91777485
123MP0008875_abnormal_xenobiotic_pharmacok0.91741781
124MP0005187_abnormal_penis_morphology0.91573223
125MP0002925_abnormal_cardiovascular_devel0.91316086
126MP0003385_abnormal_body_wall0.90780579
127MP0004885_abnormal_endolymph0.89631507
128MP0001119_abnormal_female_reproductive0.89198615
129MP0005391_vision/eye_phenotype0.89035493
130MP0006036_abnormal_mitochondrial_physio0.87956167
131MP0004264_abnormal_extraembryonic_tissu0.87442363
132MP0003698_abnormal_male_reproductive0.86818753
133MP0001849_ear_inflammation0.86657940
134MP0003315_abnormal_perineum_morphology0.84532977
135MP0002114_abnormal_axial_skeleton0.84010912
136MP0002233_abnormal_nose_morphology0.82992162
137MP0003011_delayed_dark_adaptation0.81889045
138MP0001764_abnormal_homeostasis0.81878761
139MP0002272_abnormal_nervous_system0.81465122
140MP0003122_maternal_imprinting0.81429314
141MP0002210_abnormal_sex_determination0.81258460
142MP0000049_abnormal_middle_ear0.81210144
143MP0000516_abnormal_urinary_system0.80956890
144MP0005367_renal/urinary_system_phenotyp0.80956890
145MP0005174_abnormal_tail_pigmentation0.80746061
146MP0003137_abnormal_impulse_conducting0.80265373
147MP0004924_abnormal_behavior0.79171841
148MP0005386_behavior/neurological_phenoty0.79171841
149MP0002081_perinatal_lethality0.78569156
150MP0002116_abnormal_craniofacial_bone0.78382622
151MP0002693_abnormal_pancreas_physiology0.78051878
152MP0003115_abnormal_respiratory_system0.77459635
153MP0002932_abnormal_joint_morphology0.76342322
154MP0006035_abnormal_mitochondrial_morpho0.75347202
155MP0001944_abnormal_pancreas_morphology0.75093644
156MP0005623_abnormal_meninges_morphology0.74813188
157MP0001299_abnormal_eye_distance/0.74651328
158MP0002019_abnormal_tumor_incidence0.72435499
159MP0008770_decreased_survivor_rate0.72407534
160MP0005499_abnormal_olfactory_system0.70664008
161MP0005394_taste/olfaction_phenotype0.70664008
162MP0001145_abnormal_male_reproductive0.69188418
163MP0000566_synostosis0.66978674
164MP0002177_abnormal_outer_ear0.66123977
165MP0001784_abnormal_fluid_regulation0.65453062
166MP0002282_abnormal_trachea_morphology0.65103583
167MP0003705_abnormal_hypodermis_morpholog0.64034260
168MP0002075_abnormal_coat/hair_pigmentati0.63921715

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.01910905
2Pancreatic fibrosis (HP:0100732)3.75451421
3True hermaphroditism (HP:0010459)3.50874745
4Volvulus (HP:0002580)3.15983092
5Hypothermia (HP:0002045)3.14921627
6Molar tooth sign on MRI (HP:0002419)3.06507316
7Abnormality of midbrain morphology (HP:0002418)3.06507316
8Nephronophthisis (HP:0000090)2.90569574
9Neoplasm of the adrenal cortex (HP:0100641)2.87409430
10Abnormality of the labia minora (HP:0012880)2.84525346
11Ependymoma (HP:0002888)2.71426999
12Congenital stationary night blindness (HP:0007642)2.71031154
13Short 4th metacarpal (HP:0010044)2.68161609
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68161609
15Intestinal atresia (HP:0011100)2.65343979
16Thyroiditis (HP:0100646)2.63798915
17Neoplasm of the oral cavity (HP:0100649)2.62930317
18Abnormality of the renal cortex (HP:0011035)2.59706687
19Medulloblastoma (HP:0002885)2.58737030
20Abnormality of the renal medulla (HP:0100957)2.58156232
21Supernumerary spleens (HP:0009799)2.57955747
22Methylmalonic acidemia (HP:0002912)2.57292546
23Progressive macrocephaly (HP:0004481)2.45193446
24Congenital, generalized hypertrichosis (HP:0004540)2.44590546
25Esophageal atresia (HP:0002032)2.44469273
26Chromsome breakage (HP:0040012)2.41540879
27Abnormal number of incisors (HP:0011064)2.38386277
28Supernumerary ribs (HP:0005815)2.38343462
29Increased nuchal translucency (HP:0010880)2.38074639
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37101877
31Proximal placement of thumb (HP:0009623)2.36564965
32Medial flaring of the eyebrow (HP:0010747)2.35825981
33Abnormality of the astrocytes (HP:0100707)2.33882759
34Astrocytoma (HP:0009592)2.33882759
35Ectopic kidney (HP:0000086)2.29804175
36Deviation of the thumb (HP:0009603)2.27684188
37Chronic hepatic failure (HP:0100626)2.24179702
38Breast carcinoma (HP:0003002)2.23135293
39Selective tooth agenesis (HP:0001592)2.22292811
40Glioma (HP:0009733)2.19591206
41Colon cancer (HP:0003003)2.19527014
42Abnormality of the fingertips (HP:0001211)2.18854247
43Supernumerary bones of the axial skeleton (HP:0009144)2.18259905
44Cystic liver disease (HP:0006706)2.17927328
45Absent radius (HP:0003974)2.16733666
46Abolished electroretinogram (ERG) (HP:0000550)2.14121960
47Birth length less than 3rd percentile (HP:0003561)2.12309415
48Stomach cancer (HP:0012126)2.11618211
49Acute necrotizing encephalopathy (HP:0006965)2.10768028
50Sclerocornea (HP:0000647)2.09249361
51Furrowed tongue (HP:0000221)2.08224832
52Long eyelashes (HP:0000527)2.07924276
53Prominent nose (HP:0000448)2.07682030
54Aplasia involving forearm bones (HP:0009822)2.07486704
55Absent forearm bone (HP:0003953)2.07486704
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.07026980
57Renal cortical cysts (HP:0000803)2.05223401
58Pendular nystagmus (HP:0012043)2.04796225
59Meckel diverticulum (HP:0002245)2.04425731
60Attenuation of retinal blood vessels (HP:0007843)2.03163952
61Anencephaly (HP:0002323)2.02615645
62Polydipsia (HP:0001959)2.01393058
63Abnormal drinking behavior (HP:0030082)2.01393058
64Increased CSF lactate (HP:0002490)2.00902361
65Abnormality of chromosome stability (HP:0003220)2.00053840
66Preaxial hand polydactyly (HP:0001177)2.00010385
67Abnormality of the nasal septum (HP:0000419)1.97553952
68Abnormal rod and cone electroretinograms (HP:0008323)1.96113801
69Anal stenosis (HP:0002025)1.94105270
70Abnormality of the ileum (HP:0001549)1.93838598
71Abnormal biliary tract physiology (HP:0012439)1.93355244
72Bile duct proliferation (HP:0001408)1.93355244
73Methylmalonic aciduria (HP:0012120)1.92896953
74Male pseudohermaphroditism (HP:0000037)1.92775273
75Median cleft lip (HP:0000161)1.92382512
76Dandy-Walker malformation (HP:0001305)1.91797922
77Hyperinsulinemic hypoglycemia (HP:0000825)1.91528039
78Rib fusion (HP:0000902)1.91483551
79Patellar aplasia (HP:0006443)1.91454237
80Heterotopia (HP:0002282)1.90745508
81Oligodactyly (hands) (HP:0001180)1.90677327
82Tubular atrophy (HP:0000092)1.90236665
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.89350467
84Mitochondrial inheritance (HP:0001427)1.89094285
85Abnormality of vitamin B metabolism (HP:0004340)1.88864055
86Acute encephalopathy (HP:0006846)1.87253191
87Broad-based gait (HP:0002136)1.87013086
88Gaze-evoked nystagmus (HP:0000640)1.86369156
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.86234703
90Hypoplasia of the fovea (HP:0007750)1.86234703
91Neoplasm of the adrenal gland (HP:0100631)1.85964693
92Trigonocephaly (HP:0000243)1.85849705
93Aplasia/Hypoplasia of the patella (HP:0006498)1.85664957
94Broad thumb (HP:0011304)1.85562410
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84079431
96Clubbing of toes (HP:0100760)1.82695773
97Oligodactyly (HP:0012165)1.82250470
98Atresia of the external auditory canal (HP:0000413)1.81933075
99Genital tract atresia (HP:0001827)1.81676348
100Gastrointestinal atresia (HP:0002589)1.80511105
101Abnormality of the 4th metacarpal (HP:0010012)1.79644491
102Neoplasm of striated muscle (HP:0009728)1.78763744
103Progressive inability to walk (HP:0002505)1.78723475
104Hamartoma of the eye (HP:0010568)1.77624111
105Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77329075
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.77085296
107Abnormality of the pancreatic islet cells (HP:0006476)1.76600836
108Abnormality of endocrine pancreas physiology (HP:0012093)1.76600836
109Postaxial foot polydactyly (HP:0001830)1.75580118
110Gastrointestinal carcinoma (HP:0002672)1.74324822
111Malignant gastrointestinal tract tumors (HP:0006749)1.74324822
112Abnormality of the antihelix (HP:0009738)1.74036043
113Febrile seizures (HP:0002373)1.73828139
114Sparse lateral eyebrow (HP:0005338)1.73747325
115Facial hemangioma (HP:0000329)1.73680801
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73426617
117Abnormality of the carotid arteries (HP:0005344)1.73032239
118Acute lymphatic leukemia (HP:0006721)1.72891789
119Pancreatic islet-cell hyperplasia (HP:0004510)1.72587778
120Duplicated collecting system (HP:0000081)1.72507292
121Rhabdomyosarcoma (HP:0002859)1.71644420
122Abnormality of the fovea (HP:0000493)1.71562410
123Obsessive-compulsive behavior (HP:0000722)1.70623534
124Hypomagnesemia (HP:0002917)1.70376281
125Optic nerve hypoplasia (HP:0000609)1.70242636
126Renal duplication (HP:0000075)1.70039728
127Hyperventilation (HP:0002883)1.69348836
128Reticulocytopenia (HP:0001896)1.69324635
129Renal hypoplasia (HP:0000089)1.69263878
130Adrenal hypoplasia (HP:0000835)1.69180652
131Hypoplastic labia majora (HP:0000059)1.68570149
132Hyperacusis (HP:0010780)1.68340782
133Asplenia (HP:0001746)1.68175220
134Sloping forehead (HP:0000340)1.68151174
135Abnormality of the phalanges of the 5th finger (HP:0004213)1.67953092
136Pelvic girdle muscle weakness (HP:0003749)1.67292229
137Hemiparesis (HP:0001269)1.67241700
138Alveolar cell carcinoma (HP:0006519)1.67148423
139Ketoacidosis (HP:0001993)1.66568144
140Polyuria (HP:0000103)1.66378544
141Shallow orbits (HP:0000586)1.66323841
142Conjunctival hamartoma (HP:0100780)1.65959211
143Myelodysplasia (HP:0002863)1.65770364
144Skull defect (HP:0001362)1.65738388
145Severe combined immunodeficiency (HP:0004430)1.65708500
146Postaxial hand polydactyly (HP:0001162)1.65694443
147Aqueductal stenosis (HP:0002410)1.65578557
148Neoplasm of the tracheobronchial system (HP:0100552)1.65115401
149Hypoglycemic seizures (HP:0002173)1.65097887
150Abnormality of the preputium (HP:0100587)1.65014949
151Basal cell carcinoma (HP:0002671)1.64876953
152Aplasia/hypoplasia of the uterus (HP:0008684)1.64646585
153Congenital hepatic fibrosis (HP:0002612)1.64414142
154Abnormality of DNA repair (HP:0003254)1.64346926
155Vaginal atresia (HP:0000148)1.63980611
156Duodenal stenosis (HP:0100867)1.63750149
157Small intestinal stenosis (HP:0012848)1.63750149
158Congenital primary aphakia (HP:0007707)1.63495655
159Fair hair (HP:0002286)1.63149674
160Increased hepatocellular lipid droplets (HP:0006565)1.62930339
161Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62788026
162Skin tags (HP:0010609)1.62726867
163Microtia (HP:0008551)1.60349239
164Hemivertebrae (HP:0002937)1.59707234
165Abnormality of chromosome segregation (HP:0002916)1.57273468
166Broad phalanges of the hand (HP:0009768)1.56974081
167Chin dimple (HP:0010751)1.56870029
168Short thumb (HP:0009778)1.56028669
169Tracheoesophageal fistula (HP:0002575)1.55810456
170Overriding aorta (HP:0002623)1.55789506
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.55696356
172Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55161236
173Aplasia/Hypoplasia of the earlobes (HP:0009906)1.54506762
174Limited elbow extension (HP:0001377)1.54478471
175Anophthalmia (HP:0000528)1.53148138
176Absent thumb (HP:0009777)1.52373111
177Midline defect of the nose (HP:0004122)1.52235577
178Abnormality of the diencephalon (HP:0010662)1.50490813
179Biliary tract neoplasm (HP:0100574)1.49654347
180Absent frontal sinuses (HP:0002688)1.49504032
181Abnormality of the incisor (HP:0000676)1.48783030
182Hypoplasia of the maxilla (HP:0000327)1.48651992
183Blepharitis (HP:0000498)1.48626015
184Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.48585577
185Short 1st metacarpal (HP:0010034)1.48585577
186Abnormality of the parietal bone (HP:0002696)1.47722691
187Lip pit (HP:0100267)1.47323483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.32162699
2CDK124.59646308
3CDC73.91306128
4NUAK13.08269957
5BRD43.08093422
6NEK23.02462247
7MKNK12.95980308
8MST42.89013273
9TRIM282.83756567
10WEE12.74035284
11SRPK12.70094703
12TNIK2.69887092
13MKNK22.68793030
14EIF2AK32.59482343
15BMPR1B2.47683550
16PNCK2.47174648
17WNK32.33176698
18DYRK32.20540877
19EPHA22.13321806
20PLK22.12291127
21TTK2.07137289
22SIK21.94114841
23GRK11.93904836
24MAP3K101.90173550
25MAP4K21.88795726
26TAF11.85168016
27EEF2K1.75004787
28ATR1.73886744
29CDK61.69618896
30CASK1.67476211
31CHEK21.67257817
32CDK41.65975133
33BCR1.58528656
34ALK1.58090812
35CDK71.57440396
36VRK21.56520091
37RPS6KB21.54789675
38CHEK11.53932066
39LATS11.47724832
40BUB11.47174116
41TSSK61.45769521
42RPS6KA41.44933055
43ERBB31.44288564
44ADRBK21.43340033
45STK391.36591553
46PASK1.33995276
47MAP3K41.33397465
48PLK11.33392096
49STK101.31747759
50PLK31.27726018
51EIF2AK11.25784231
52OXSR11.25729122
53STK241.24030254
54STK31.23992930
55AURKB1.22998202
56ATM1.22490289
57MAPK131.20367985
58INSRR1.18427568
59ICK1.15575736
60CAMK1G1.14181739
61FGFR21.13286335
62SIK31.11521649
63CAMK1D1.09772491
64CDK21.09676857
65PAK31.07855083
66MTOR1.06916768
67TYRO31.03337980
68STK41.01284582
69CLK11.00790814
70ACVR1B1.00383898
71PINK10.97515547
72MAP3K80.96797357
73STK38L0.96253458
74FGFR10.93267138
75CDK90.92424524
76CSNK1A1L0.90774158
77PRKCE0.90397548
78FER0.89758690
79CDK10.88768681
80MELK0.86176272
81TAOK30.83887117
82WNK40.83004004
83BRSK20.82493363
84PAK20.81376470
85MARK30.81130797
86EIF2AK20.80494552
87TXK0.79589612
88PLK40.78843661
89CSNK1D0.78798538
90RPS6KA50.78689157
91PIM10.78236107
92DDR20.77532941
93CSNK1E0.77286359
94PRKDC0.73872270
95ZAK0.70716111
96VRK10.69653910
97CDK30.67473321
98TLK10.67253075
99NEK10.66954367
100MAPK140.65754184
101EPHA40.63975984
102AKT30.62925000
103PDGFRB0.62844970
104AKT20.61695791
105PRKCG0.61258268
106YES10.61118253
107TEC0.60145740
108PDGFRA0.59028740
109GSK3B0.57621762
110DYRK20.57577816
111DYRK1A0.57121255
112TGFBR10.56955902
113UHMK10.55430320
114MAPK100.55267608
115AURKA0.54996625
116CSNK1G10.53735474
117STK160.53417135
118MAP2K70.53236327
119MAPKAPK50.52965146
120PAK40.51937001
121BMX0.48471691
122AKT10.48375251
123CSNK2A20.47967928
124SCYL20.47737876
125MAPK10.47252935
126ADRBK10.47106084
127PTK60.46728538
128CHUK0.46507440
129IKBKB0.45825585
130PRKCI0.45491822
131HIPK20.45477286
132FGFR30.45029307
133CDC42BPA0.44440199
134BMPR20.41915713
135KSR10.41418807
136GRK50.40279284
137TRPM70.39775074
138MAPK80.39445179
139PHKG20.38838423
140PHKG10.38838423
141NLK0.38719797
142MAPK90.37794963
143PRKCQ0.36285520
144MARK20.34232109
145CSNK1G20.34195080
146MAPKAPK30.33917544
147DYRK1B0.33868075
148ABL10.32004033
149BRSK10.30582858
150CSNK1A10.29085303
151ERBB20.28552109
152FLT30.28338115
153CSNK1G30.27685392
154IGF1R0.27645491
155MUSK0.27121438
156GSK3A0.26218180
157DAPK20.25075098
158PTK2B0.24079700
159BCKDK0.23848580

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.92579465
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97196038
3* Spliceosome_Homo sapiens_hsa030402.71318327
4Proteasome_Homo sapiens_hsa030502.64236059
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.46603812
6RNA transport_Homo sapiens_hsa030132.38795493
7mRNA surveillance pathway_Homo sapiens_hsa030152.31476814
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26022443
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25399751
10Cell cycle_Homo sapiens_hsa041102.23239805
11Propanoate metabolism_Homo sapiens_hsa006402.23097988
12Butanoate metabolism_Homo sapiens_hsa006502.22695620
13Mismatch repair_Homo sapiens_hsa034302.15133164
14DNA replication_Homo sapiens_hsa030302.14164939
15Fanconi anemia pathway_Homo sapiens_hsa034602.02838485
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91033442
17Non-homologous end-joining_Homo sapiens_hsa034501.89723028
18Selenocompound metabolism_Homo sapiens_hsa004501.82978329
19Oxidative phosphorylation_Homo sapiens_hsa001901.75677734
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72053029
21Caffeine metabolism_Homo sapiens_hsa002321.66878048
22Nitrogen metabolism_Homo sapiens_hsa009101.63723921
23Base excision repair_Homo sapiens_hsa034101.60613462
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59347244
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58421065
26MicroRNAs in cancer_Homo sapiens_hsa052061.50655895
27Nucleotide excision repair_Homo sapiens_hsa034201.50203575
28Homologous recombination_Homo sapiens_hsa034401.48776875
29Linoleic acid metabolism_Homo sapiens_hsa005911.47606131
30Ether lipid metabolism_Homo sapiens_hsa005651.46905744
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44314950
32Basal cell carcinoma_Homo sapiens_hsa052171.42569645
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42005925
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41911696
35Steroid biosynthesis_Homo sapiens_hsa001001.39594314
36p53 signaling pathway_Homo sapiens_hsa041151.39349835
37Parkinsons disease_Homo sapiens_hsa050121.39329647
38Systemic lupus erythematosus_Homo sapiens_hsa053221.37675907
39RNA degradation_Homo sapiens_hsa030181.37663096
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31390448
41Basal transcription factors_Homo sapiens_hsa030221.31030205
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31026017
43Tryptophan metabolism_Homo sapiens_hsa003801.30657763
44Notch signaling pathway_Homo sapiens_hsa043301.25692390
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25372857
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23938497
47Viral carcinogenesis_Homo sapiens_hsa052031.22860601
48Hippo signaling pathway_Homo sapiens_hsa043901.20879330
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19739287
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18770916
51Chronic myeloid leukemia_Homo sapiens_hsa052201.18166874
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18072720
53Small cell lung cancer_Homo sapiens_hsa052221.17764281
54Colorectal cancer_Homo sapiens_hsa052101.17201586
55Peroxisome_Homo sapiens_hsa041461.16792289
56HTLV-I infection_Homo sapiens_hsa051661.11682308
57Hedgehog signaling pathway_Homo sapiens_hsa043401.09740247
58RNA polymerase_Homo sapiens_hsa030201.09546583
59Herpes simplex infection_Homo sapiens_hsa051681.09456142
60Oocyte meiosis_Homo sapiens_hsa041141.08714722
61Fatty acid elongation_Homo sapiens_hsa000621.08216229
62mTOR signaling pathway_Homo sapiens_hsa041501.06710688
63TGF-beta signaling pathway_Homo sapiens_hsa043501.06438532
64Adherens junction_Homo sapiens_hsa045201.06428708
65Regulation of autophagy_Homo sapiens_hsa041401.05208271
66Type I diabetes mellitus_Homo sapiens_hsa049401.01783818
67Epstein-Barr virus infection_Homo sapiens_hsa051691.00929214
68Alcoholism_Homo sapiens_hsa050340.98368476
69Ribosome_Homo sapiens_hsa030100.97369176
70Wnt signaling pathway_Homo sapiens_hsa043100.96615885
71Vitamin B6 metabolism_Homo sapiens_hsa007500.95982248
72Nicotine addiction_Homo sapiens_hsa050330.95948716
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93550553
74Antigen processing and presentation_Homo sapiens_hsa046120.92441986
75One carbon pool by folate_Homo sapiens_hsa006700.91117363
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.90755482
77Prostate cancer_Homo sapiens_hsa052150.90458596
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.86475422
79Huntingtons disease_Homo sapiens_hsa050160.86417866
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.84675558
81Proteoglycans in cancer_Homo sapiens_hsa052050.83240675
82Pathways in cancer_Homo sapiens_hsa052000.82700323
83B cell receptor signaling pathway_Homo sapiens_hsa046620.82245450
84Purine metabolism_Homo sapiens_hsa002300.82015279
85Olfactory transduction_Homo sapiens_hsa047400.81337656
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81115296
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79433220
88Primary immunodeficiency_Homo sapiens_hsa053400.78921442
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.78566457
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78429319
91Phototransduction_Homo sapiens_hsa047440.78421056
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77869242
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77250099
94Dorso-ventral axis formation_Homo sapiens_hsa043200.76981730
95Renal cell carcinoma_Homo sapiens_hsa052110.76342580
96Chemical carcinogenesis_Homo sapiens_hsa052040.75334850
97Alzheimers disease_Homo sapiens_hsa050100.74472534
98T cell receptor signaling pathway_Homo sapiens_hsa046600.73207930
99Taste transduction_Homo sapiens_hsa047420.72114870
100Retinol metabolism_Homo sapiens_hsa008300.72043755
101Hepatitis B_Homo sapiens_hsa051610.70957708
102FoxO signaling pathway_Homo sapiens_hsa040680.70702106
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70222784
104Acute myeloid leukemia_Homo sapiens_hsa052210.70048328
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69734760
106Pancreatic cancer_Homo sapiens_hsa052120.69027778
107Asthma_Homo sapiens_hsa053100.68588093
108Collecting duct acid secretion_Homo sapiens_hsa049660.67640075
109Non-small cell lung cancer_Homo sapiens_hsa052230.67102677
110Viral myocarditis_Homo sapiens_hsa054160.65982649
111Lysine degradation_Homo sapiens_hsa003100.64727213
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63989801
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63912612
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63602620
115Endometrial cancer_Homo sapiens_hsa052130.62990719
116Tight junction_Homo sapiens_hsa045300.61872323
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61466967
118ErbB signaling pathway_Homo sapiens_hsa040120.61247730
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.60966874
120MAPK signaling pathway_Homo sapiens_hsa040100.60689759
121Measles_Homo sapiens_hsa051620.60600312
122Serotonergic synapse_Homo sapiens_hsa047260.60548569
123Axon guidance_Homo sapiens_hsa043600.59784785
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59644250
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59237404
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58918571
127Apoptosis_Homo sapiens_hsa042100.58715283
128Melanoma_Homo sapiens_hsa052180.57986006
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.57951569
130Hematopoietic cell lineage_Homo sapiens_hsa046400.57562825
131beta-Alanine metabolism_Homo sapiens_hsa004100.56926153
132Focal adhesion_Homo sapiens_hsa045100.56455278
133Pyrimidine metabolism_Homo sapiens_hsa002400.54603008
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54444163
135Insulin secretion_Homo sapiens_hsa049110.54260380
136Inositol phosphate metabolism_Homo sapiens_hsa005620.54247898
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54197005
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54080125
139Sulfur metabolism_Homo sapiens_hsa009200.53657005
140Choline metabolism in cancer_Homo sapiens_hsa052310.53240066
141Estrogen signaling pathway_Homo sapiens_hsa049150.53184868
142Metabolic pathways_Homo sapiens_hsa011000.53125363
143Glioma_Homo sapiens_hsa052140.52222850
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51854084
145ECM-receptor interaction_Homo sapiens_hsa045120.51828818
146Osteoclast differentiation_Homo sapiens_hsa043800.51596395
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.51594939
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51329150
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50972825
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50067570
151Rap1 signaling pathway_Homo sapiens_hsa040150.49769519
152TNF signaling pathway_Homo sapiens_hsa046680.49214155
153Influenza A_Homo sapiens_hsa051640.47887347
154Melanogenesis_Homo sapiens_hsa049160.46953905
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44969935
156Circadian rhythm_Homo sapiens_hsa047100.44783571
157Bladder cancer_Homo sapiens_hsa052190.43915627
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43148738
159Toxoplasmosis_Homo sapiens_hsa051450.42115261
160HIF-1 signaling pathway_Homo sapiens_hsa040660.41858031
161Circadian entrainment_Homo sapiens_hsa047130.40671132
162Arachidonic acid metabolism_Homo sapiens_hsa005900.40616412
163Amphetamine addiction_Homo sapiens_hsa050310.39930573
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39070975
165Fatty acid metabolism_Homo sapiens_hsa012120.38565010
166Glutamatergic synapse_Homo sapiens_hsa047240.37844188
167Morphine addiction_Homo sapiens_hsa050320.35941691
168Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34136915
169ABC transporters_Homo sapiens_hsa020100.31496084
170Dopaminergic synapse_Homo sapiens_hsa047280.30823240
171Glutathione metabolism_Homo sapiens_hsa004800.30692007

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