TPX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.06206378
2mitotic sister chromatid segregation (GO:0000070)5.45562682
3protein localization to chromosome, centromeric region (GO:0071459)5.38852888
4mitotic metaphase plate congression (GO:0007080)5.34796650
5kinetochore organization (GO:0051383)5.25471049
6sister chromatid segregation (GO:0000819)5.24911766
7mitotic chromosome condensation (GO:0007076)5.08308935
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.88379611
9DNA unwinding involved in DNA replication (GO:0006268)4.81694109
10metaphase plate congression (GO:0051310)4.81631526
11nuclear pore organization (GO:0006999)4.63827960
12attachment of spindle microtubules to kinetochore (GO:0008608)4.61644638
13kinetochore assembly (GO:0051382)4.58523389
14nuclear pore complex assembly (GO:0051292)4.53229672
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.53221871
16mitotic nuclear envelope disassembly (GO:0007077)4.49384113
17establishment of chromosome localization (GO:0051303)4.45342395
18CENP-A containing nucleosome assembly (GO:0034080)4.41326994
19chromatin remodeling at centromere (GO:0031055)4.36521113
20positive regulation of chromosome segregation (GO:0051984)4.23267704
21DNA ligation (GO:0006266)4.22431347
22establishment of integrated proviral latency (GO:0075713)4.21543526
23* regulation of spindle organization (GO:0090224)4.20328969
24membrane disassembly (GO:0030397)4.19289007
25nuclear envelope disassembly (GO:0051081)4.19289007
26DNA strand elongation involved in DNA replication (GO:0006271)4.08701153
27DNA replication-independent nucleosome organization (GO:0034724)4.06375069
28DNA replication-independent nucleosome assembly (GO:0006336)4.06375069
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.06112112
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.06112112
31positive regulation of mitotic sister chromatid separation (GO:1901970)4.06112112
32DNA replication initiation (GO:0006270)4.04200443
33DNA replication-dependent nucleosome assembly (GO:0006335)4.03387662
34DNA replication-dependent nucleosome organization (GO:0034723)4.03387662
35protein localization to chromosome (GO:0034502)4.00655399
36spindle checkpoint (GO:0031577)3.99971515
37regulation of chromosome segregation (GO:0051983)3.98883837
38meiotic chromosome segregation (GO:0045132)3.97323086
39DNA replication checkpoint (GO:0000076)3.92522248
40DNA strand elongation (GO:0022616)3.87726114
41spindle assembly checkpoint (GO:0071173)3.81158857
42regulation of mitotic metaphase/anaphase transition (GO:0030071)3.81125846
43mitotic sister chromatid cohesion (GO:0007064)3.81024669
44chromosome segregation (GO:0007059)3.80893782
45histone exchange (GO:0043486)3.79477772
46negative regulation of chromosome segregation (GO:0051985)3.78435783
47telomere maintenance via semi-conservative replication (GO:0032201)3.75993789
48regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.73827830
49regulation of sister chromatid cohesion (GO:0007063)3.73507659
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.72492138
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.72492138
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.72492138
53negative regulation of sister chromatid segregation (GO:0033046)3.72492138
54mitotic recombination (GO:0006312)3.72136597
55mitotic spindle assembly checkpoint (GO:0007094)3.68903741
56mitotic spindle checkpoint (GO:0071174)3.67959451
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.63301579
58regulation of sister chromatid segregation (GO:0033045)3.59222973
59regulation of mitotic sister chromatid separation (GO:0010965)3.59222973
60regulation of mitotic sister chromatid segregation (GO:0033047)3.59222973
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59174816
62chromosome condensation (GO:0030261)3.56909170
63telomere maintenance via recombination (GO:0000722)3.53858211
64regulation of centrosome cycle (GO:0046605)3.53833327
65mitotic cytokinesis (GO:0000281)3.51384717
66chromatin assembly or disassembly (GO:0006333)3.51261778
67pore complex assembly (GO:0046931)3.46706147
68DNA duplex unwinding (GO:0032508)3.42159165
69DNA geometric change (GO:0032392)3.41551008
70DNA topological change (GO:0006265)3.36955637
71microtubule depolymerization (GO:0007019)3.35047252
72regulation of translational fidelity (GO:0006450)3.34359236
73nuclear envelope organization (GO:0006998)3.31037632
74folic acid-containing compound biosynthetic process (GO:0009396)3.30107034
75protein complex localization (GO:0031503)3.29725912
76non-recombinational repair (GO:0000726)3.27214946
77double-strand break repair via nonhomologous end joining (GO:0006303)3.27214946
78* regulation of mitotic spindle organization (GO:0060236)3.25814479
79spindle assembly involved in mitosis (GO:0090307)3.24754550
80IMP biosynthetic process (GO:0006188)3.23642366
81ATP-dependent chromatin remodeling (GO:0043044)3.22850713
82telomere maintenance via telomere lengthening (GO:0010833)3.21431580
83protein K6-linked ubiquitination (GO:0085020)3.17622007
84establishment of viral latency (GO:0019043)3.16915415
85formation of translation preinitiation complex (GO:0001731)3.15184582
86mitotic spindle organization (GO:0007052)3.15076924
87DNA packaging (GO:0006323)3.14903264
88DNA conformation change (GO:0071103)3.14702093
89histone-serine phosphorylation (GO:0035404)3.13230231
90establishment of mitotic spindle localization (GO:0040001)3.13180471
91spindle organization (GO:0007051)3.10849661
92regulation of centriole replication (GO:0046599)3.10373607
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.09135154
94nucleobase biosynthetic process (GO:0046112)3.08397799
95heterochromatin organization (GO:0070828)3.04603149
96regulation of RNA export from nucleus (GO:0046831)3.02660824
97mitotic cell cycle (GO:0000278)3.02615672
98regulation of telomere maintenance via telomerase (GO:0032210)3.02124493
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01489811
100ventricular cardiac muscle cell development (GO:0055015)2.98853925
101regulation of histone H3-K9 methylation (GO:0051570)2.98404471
102maturation of SSU-rRNA (GO:0030490)2.94596365
103chromosome organization (GO:0051276)2.94252137
104chromatin assembly (GO:0031497)2.93662621
105mitotic G2/M transition checkpoint (GO:0044818)2.91976762
106microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.91750340
107regulation of double-strand break repair via homologous recombination (GO:0010569)2.91369758
108regulation of exit from mitosis (GO:0007096)2.90367561
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90288682
110negative regulation of mitosis (GO:0045839)2.88826948
111IMP metabolic process (GO:0046040)2.83493772
112regulation of DNA endoreduplication (GO:0032875)2.82506897
113purine nucleobase biosynthetic process (GO:0009113)2.81048200
114mitotic DNA integrity checkpoint (GO:0044774)2.80259216
115ribosome assembly (GO:0042255)2.80169933
116regulation of centrosome duplication (GO:0010824)2.79480843
117mitotic cell cycle checkpoint (GO:0007093)2.78423279
118regulation of double-strand break repair (GO:2000779)2.77310166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.88243748
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.21145022
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.66948220
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.33179881
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.81342473
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09510160
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82878386
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.75585476
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73890391
10* AR_21909140_ChIP-Seq_LNCAP_Human2.70921335
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56397529
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48808818
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.33253121
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32188000
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29561894
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28668274
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.26539609
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21532805
19XRN2_22483619_ChIP-Seq_HELA_Human2.19113841
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17462488
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.05525636
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98492163
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88092744
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.84347119
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81640232
26VDR_23849224_ChIP-Seq_CD4+_Human1.76013354
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75097262
28DCP1A_22483619_ChIP-Seq_HELA_Human1.69096373
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68867663
30TTF2_22483619_ChIP-Seq_HELA_Human1.68112026
31FOXP3_21729870_ChIP-Seq_TREG_Human1.66614048
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66066071
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65991173
34MYC_22102868_ChIP-Seq_BL_Human1.64548142
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62254878
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59195415
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56018148
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.55947269
39CIITA_25753668_ChIP-Seq_RAJI_Human1.49779550
40* ELK1_19687146_ChIP-ChIP_HELA_Human1.48034008
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47862789
42KDM5A_27292631_Chip-Seq_BREAST_Human1.45767714
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45132612
44* GABP_19822575_ChIP-Seq_HepG2_Human1.43342536
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40966178
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39341895
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.37425568
48ZNF263_19887448_ChIP-Seq_K562_Human1.36184882
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35382155
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29646697
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29632378
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25458535
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24829062
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24780241
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23614423
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23409867
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23151445
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22740405
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21976819
60* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18905586
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18830430
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18756197
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18394712
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17485476
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17136405
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16704602
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12498756
68* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11241608
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10501565
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08712803
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.06042260
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05102531
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04851455
74* SOX17_20123909_ChIP-Seq_XEN_Mouse1.04073244
75TFEB_21752829_ChIP-Seq_HELA_Human1.03400449
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03018184
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02557831
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01631232
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99002383
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98963025
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98702836
82TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97861673
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97047281
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.93756565
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92631836
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92422349
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92162725
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90570103
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90570103
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90570103
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90456420
92* VDR_21846776_ChIP-Seq_THP-1_Human0.90443943
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90263610
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88527311
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87207998
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86177069
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84731479
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84650111
99MYC_18940864_ChIP-ChIP_HL60_Human0.84426174
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84089858
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82366612
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81657032
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80752136
104SRF_21415370_ChIP-Seq_HL-1_Mouse0.80637519
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80260414
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78754699
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77105959
108TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76397967
109* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75880189
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75057435
111CLOCK_20551151_ChIP-Seq_293T_Human0.74908270
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74757488
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74088719
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74054040
115CHD1_26751641_Chip-Seq_LNCaP_Human0.73746528
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72714525
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71886690
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71477811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.04185680
2MP0003111_abnormal_nucleus_morphology4.67711479
3MP0010094_abnormal_chromosome_stability4.59314379
4MP0004957_abnormal_blastocyst_morpholog4.08712572
5MP0003077_abnormal_cell_cycle4.06199375
6MP0008057_abnormal_DNA_replication3.56091726
7MP0008007_abnormal_cellular_replicative2.80717784
8MP0008932_abnormal_embryonic_tissue2.66360104
9MP0008058_abnormal_DNA_repair2.58709163
10MP0001730_embryonic_growth_arrest2.41085865
11MP0000350_abnormal_cell_proliferation2.34104215
12MP0003123_paternal_imprinting2.32982886
13MP0010307_abnormal_tumor_latency2.29774085
14MP0010352_gastrointestinal_tract_polyps2.21236960
15MP0009697_abnormal_copulation2.14786743
16MP0010030_abnormal_orbit_morphology2.09659088
17MP0005076_abnormal_cell_differentiation1.94131403
18MP0005380_embryogenesis_phenotype1.93207196
19MP0001672_abnormal_embryogenesis/_devel1.93207196
20MP0001697_abnormal_embryo_size1.87515972
21MP0002085_abnormal_embryonic_tissue1.77828329
22MP0009053_abnormal_anal_canal1.73012528
23MP0003984_embryonic_growth_retardation1.72365731
24MP0008877_abnormal_DNA_methylation1.72257990
25MP0002396_abnormal_hematopoietic_system1.71168216
26MP0002084_abnormal_developmental_patter1.70477768
27MP0002088_abnormal_embryonic_growth/wei1.69378783
28MP0003950_abnormal_plasma_membrane1.69271985
29MP0004233_abnormal_muscle_weight1.64721782
30MP0003705_abnormal_hypodermis_morpholog1.64590478
31MP0003786_premature_aging1.64390942
32MP0002080_prenatal_lethality1.62543182
33MP0004197_abnormal_fetal_growth/weight/1.61038449
34MP0002086_abnormal_extraembryonic_tissu1.58481960
35MP0003121_genomic_imprinting1.55006354
36MP0004808_abnormal_hematopoietic_stem1.49025919
37MP0000490_abnormal_crypts_of1.43403998
38MP0000537_abnormal_urethra_morphology1.39376945
39MP0003567_abnormal_fetal_cardiomyocyte1.36650059
40MP0004185_abnormal_adipocyte_glucose1.35298050
41MP0000313_abnormal_cell_death1.32660775
42MP0001293_anophthalmia1.27882156
43MP0003718_maternal_effect1.27652117
44MP0002019_abnormal_tumor_incidence1.26078188
45MP0003937_abnormal_limbs/digits/tail_de1.25217863
46MP0003941_abnormal_skin_development1.17167896
47MP0003890_abnormal_embryonic-extraembry1.15214835
48MP0002210_abnormal_sex_determination1.14951937
49MP0001346_abnormal_lacrimal_gland1.14682179
50MP0010234_abnormal_vibrissa_follicle1.12962140
51MP0003315_abnormal_perineum_morphology1.08933684
52MP0009278_abnormal_bone_marrow1.03106956
53MP0005501_abnormal_skin_physiology1.01735106
54MP0002111_abnormal_tail_morphology1.01409461
55MP0000358_abnormal_cell_content/1.01305594
56MP0000566_synostosis1.01136680
57MP0001145_abnormal_male_reproductive1.00466084
58MP0006292_abnormal_olfactory_placode0.99254194
59MP0003566_abnormal_cell_adhesion0.98522137
60MP0005397_hematopoietic_system_phenotyp0.97447151
61MP0001545_abnormal_hematopoietic_system0.97447151
62MP0009672_abnormal_birth_weight0.97393374
63MP0000428_abnormal_craniofacial_morphol0.97268590
64MP0000733_abnormal_muscle_development0.96105474
65MP0003119_abnormal_digestive_system0.96026267
66MP0006054_spinal_hemorrhage0.94414543
67MP0005023_abnormal_wound_healing0.93635698
68MP0005257_abnormal_intraocular_pressure0.92651776
69MP0000703_abnormal_thymus_morphology0.91414574
70MP0005408_hypopigmentation0.89431884
71MP0003115_abnormal_respiratory_system0.88277340
72MP0001915_intracranial_hemorrhage0.88265750
73MP0009703_decreased_birth_body0.87854388
74MP0001661_extended_life_span0.87650575
75MP0000432_abnormal_head_morphology0.87103597
76MP0002009_preneoplasia0.86950538
77MP0001929_abnormal_gametogenesis0.86680894
78MP0002092_abnormal_eye_morphology0.86237662
79MP0000653_abnormal_sex_gland0.86141453
80MP0002877_abnormal_melanocyte_morpholog0.85589405
81MP0004272_abnormal_basement_membrane0.85044343
82MP0001849_ear_inflammation0.83034992
83MP0003806_abnormal_nucleotide_metabolis0.82207010
84MP0009333_abnormal_splenocyte_physiolog0.82069606
85MP0003755_abnormal_palate_morphology0.81786463
86MP0003935_abnormal_craniofacial_develop0.81381783
87MP0001119_abnormal_female_reproductive0.80667580
88MP0001286_abnormal_eye_development0.79128002
89MP0005451_abnormal_body_composition0.77678171
90MP0001727_abnormal_embryo_implantation0.77221538
91MP0002932_abnormal_joint_morphology0.76406707
92MP0005621_abnormal_cell_physiology0.75936059
93MP0002697_abnormal_eye_size0.75178936
94MP0000762_abnormal_tongue_morphology0.74493164
95MP0003943_abnormal_hepatobiliary_system0.73950320
96MP0005384_cellular_phenotype0.72785721
97MP0002925_abnormal_cardiovascular_devel0.72289174
98MP0002060_abnormal_skin_morphology0.71232551
99MP0006035_abnormal_mitochondrial_morpho0.71128815
100MP0005171_absent_coat_pigmentation0.71029327
101MP0003699_abnormal_female_reproductive0.70943947
102MP0008438_abnormal_cutaneous_collagen0.70754291
103MP0002653_abnormal_ependyma_morphology0.69213222
104MP0002398_abnormal_bone_marrow0.68052820
105MP0002282_abnormal_trachea_morphology0.67463181
106MP0002722_abnormal_immune_system0.67284009
107MP0000627_abnormal_mammary_gland0.67259354
108MP0002233_abnormal_nose_morphology0.67208725
109MP0002796_impaired_skin_barrier0.67155726
110MP0000858_altered_metastatic_potential0.67036136
111MP0003385_abnormal_body_wall0.66804525
112MP0000049_abnormal_middle_ear0.66409660
113MP0005623_abnormal_meninges_morphology0.66265798
114MP0002102_abnormal_ear_morphology0.65741165
115MP0002269_muscular_atrophy0.64691821
116MP0000647_abnormal_sebaceous_gland0.62704941
117MP0003861_abnormal_nervous_system0.62203564
118MP0002114_abnormal_axial_skeleton0.61994818
119MP0003942_abnormal_urinary_system0.61957468
120MP0003221_abnormal_cardiomyocyte_apopto0.61715009
121MP0002160_abnormal_reproductive_system0.61640871
122MP0001299_abnormal_eye_distance/0.59698674
123MP0002234_abnormal_pharynx_morphology0.59685751
124MP0005389_reproductive_system_phenotype0.57830168
125MP0000689_abnormal_spleen_morphology0.57237285
126MP0003938_abnormal_ear_development0.56418161
127MP0002938_white_spotting0.55456426
128MP0000477_abnormal_intestine_morphology0.54955400
129MP0002116_abnormal_craniofacial_bone0.54672404
130MP0003448_altered_tumor_morphology0.53902777
131MP0000266_abnormal_heart_morphology0.53621137
132MP0000516_abnormal_urinary_system0.51843263

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.06257101
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83843269
3Cortical dysplasia (HP:0002539)3.56426232
4Birth length less than 3rd percentile (HP:0003561)3.38565134
5Selective tooth agenesis (HP:0001592)3.26637743
6Patellar aplasia (HP:0006443)3.21150236
7Abnormality of chromosome stability (HP:0003220)3.17224089
8Reticulocytopenia (HP:0001896)3.16691730
9Increased nuchal translucency (HP:0010880)3.09899806
10Meckel diverticulum (HP:0002245)3.09141114
11Colon cancer (HP:0003003)3.01926436
12Breast hypoplasia (HP:0003187)3.01872365
13Aplasia/Hypoplasia of the patella (HP:0006498)3.00505006
14Impulsivity (HP:0100710)2.93691930
15Small intestinal stenosis (HP:0012848)2.93029954
16Duodenal stenosis (HP:0100867)2.93029954
17Volvulus (HP:0002580)2.92920225
18Abnormality of the ileum (HP:0001549)2.92783516
19Abnormality of the labia minora (HP:0012880)2.91970466
20Medulloblastoma (HP:0002885)2.89697556
21Ependymoma (HP:0002888)2.86395747
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.82445967
23Abnormality of the preputium (HP:0100587)2.81757490
24Absent radius (HP:0003974)2.78060437
25Proximal placement of thumb (HP:0009623)2.72884492
26Rhabdomyosarcoma (HP:0002859)2.70775856
27Deviation of the thumb (HP:0009603)2.70275325
28Short 4th metacarpal (HP:0010044)2.67017055
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67017055
30Abnormal lung lobation (HP:0002101)2.66754268
31Ectopic kidney (HP:0000086)2.65839055
32Abnormality of the anterior horn cell (HP:0006802)2.64745886
33Degeneration of anterior horn cells (HP:0002398)2.64745886
34Myelodysplasia (HP:0002863)2.59682053
35Aplasia involving forearm bones (HP:0009822)2.58791846
36Absent forearm bone (HP:0003953)2.58791846
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56954060
38Carpal bone hypoplasia (HP:0001498)2.45674594
39Deep philtrum (HP:0002002)2.44881056
40Facial hemangioma (HP:0000329)2.43528032
41Abnormality of the duodenum (HP:0002246)2.42499221
42Sloping forehead (HP:0000340)2.41705863
43Nephroblastoma (Wilms tumor) (HP:0002667)2.38574045
44Atresia of the external auditory canal (HP:0000413)2.36677844
45Abnormal number of incisors (HP:0011064)2.29915934
46Absent thumb (HP:0009777)2.29811374
47Embryonal renal neoplasm (HP:0011794)2.26591440
48Oral leukoplakia (HP:0002745)2.24833841
49Cafe-au-lait spot (HP:0000957)2.22543487
50Supernumerary spleens (HP:0009799)2.21647270
5111 pairs of ribs (HP:0000878)2.20498595
52Neoplasm of the pancreas (HP:0002894)2.19039941
53High anterior hairline (HP:0009890)2.18803387
54Hyperacusis (HP:0010780)2.17116302
55High pitched voice (HP:0001620)2.15545581
56Abnormality of glycolysis (HP:0004366)2.15415971
57Agnosia (HP:0010524)2.14975456
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.12750462
59Missing ribs (HP:0000921)2.10131820
60Cholecystitis (HP:0001082)2.10067255
61Abnormal gallbladder physiology (HP:0012438)2.10067255
62Astrocytoma (HP:0009592)2.09577134
63Abnormality of the astrocytes (HP:0100707)2.09577134
64Basal cell carcinoma (HP:0002671)2.08987889
65Embryonal neoplasm (HP:0002898)2.08905788
66Insomnia (HP:0100785)2.07380552
67Abnormality of the carotid arteries (HP:0005344)2.07342681
68Triphalangeal thumb (HP:0001199)2.05535131
69Neoplasm of striated muscle (HP:0009728)2.04942282
70Multiple enchondromatosis (HP:0005701)2.04032303
71Rough bone trabeculation (HP:0100670)2.03932406
72Progressive muscle weakness (HP:0003323)2.03091100
73Ankle contracture (HP:0006466)2.02603664
74Broad distal phalanx of finger (HP:0009836)2.01807845
75Horseshoe kidney (HP:0000085)2.01488361
76Heterotopia (HP:0002282)2.01243894
77Tracheoesophageal fistula (HP:0002575)2.01072317
78Short thumb (HP:0009778)2.01047580
79Abnormality of the calcaneus (HP:0008364)2.00780549
80Orthostatic hypotension (HP:0001278)1.99258289
81Absent epiphyses (HP:0010577)1.98083825
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98083825
83Ankyloglossia (HP:0010296)1.96702281
84Duplication of thumb phalanx (HP:0009942)1.95877782
85Prominent nose (HP:0000448)1.95166443
86Microvesicular hepatic steatosis (HP:0001414)1.94574678
87Bone marrow hypocellularity (HP:0005528)1.92492825
88Abnormal umbilical cord blood vessels (HP:0011403)1.92336256
89Single umbilical artery (HP:0001195)1.92336256
90Abnormality of the fetal cardiovascular system (HP:0010948)1.92336256
91Abnormality of the umbilical cord (HP:0010881)1.92202571
92Glioma (HP:0009733)1.91715196
93Neoplasm of the colon (HP:0100273)1.89737949
94Small epiphyses (HP:0010585)1.87807970
95Microglossia (HP:0000171)1.86923583
96Gastrointestinal carcinoma (HP:0002672)1.86191182
97Malignant gastrointestinal tract tumors (HP:0006749)1.86191182
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86001444
99Overlapping toe (HP:0001845)1.84756822
100Protrusio acetabuli (HP:0003179)1.83841973
101Biliary tract neoplasm (HP:0100574)1.83702054
102Increased serum pyruvate (HP:0003542)1.82862967
103Abnormality of the 4th metacarpal (HP:0010012)1.82697086
104Arteriovenous malformation (HP:0100026)1.82274568
105Poikiloderma (HP:0001029)1.82262150
106Oligodactyly (HP:0012165)1.81234932
107Duplicated collecting system (HP:0000081)1.80670687
108Short middle phalanx of the 5th finger (HP:0004220)1.80231343
109Abnormality of abdominal situs (HP:0011620)1.80119109
110Abdominal situs inversus (HP:0003363)1.80119109
111Squamous cell carcinoma (HP:0002860)1.79924042
112Aplasia/hypoplasia of the humerus (HP:0006507)1.79418434
113Abnormality of cells of the erythroid lineage (HP:0012130)1.78251036
114Trismus (HP:0000211)1.78168820
115Hypoplastic pelvis (HP:0008839)1.77461105
116Neoplasm of the oral cavity (HP:0100649)1.76454845
117Premature graying of hair (HP:0002216)1.76072599
118Insidious onset (HP:0003587)1.75810590
119Termporal pattern (HP:0011008)1.75810590
120Renal duplication (HP:0000075)1.74411803
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74380855
122Premature rupture of membranes (HP:0001788)1.73785678
123Choanal atresia (HP:0000453)1.73674452
124Ovarian neoplasm (HP:0100615)1.73578239
125Abnormality of chromosome segregation (HP:0002916)1.72873058
126Long eyelashes (HP:0000527)1.71304609
127Overriding aorta (HP:0002623)1.71261049
128Flared metaphyses (HP:0003015)1.70668574
129Entropion (HP:0000621)1.68963237
130Hypopigmentation of the fundus (HP:0007894)1.68861332
131Shallow orbits (HP:0000586)1.68726020
132Abnormality of oral frenula (HP:0000190)1.68382298
133Progressive external ophthalmoplegia (HP:0000590)1.68212215
134Sandal gap (HP:0001852)1.68173270
135Slender long bone (HP:0003100)1.68010689
136Pelvic girdle muscle weakness (HP:0003749)1.68008373
137Facial cleft (HP:0002006)1.67847871
138Wrist flexion contracture (HP:0001239)1.66831621
139Abnormal number of erythroid precursors (HP:0012131)1.66297575
140Leiomyosarcoma (HP:0100243)1.63775888
141Uterine leiomyosarcoma (HP:0002891)1.63775888
142Clubbing of toes (HP:0100760)1.61103789
143Abnormality of reticulocytes (HP:0004312)1.60850099
144Ulnar bowing (HP:0003031)1.60119660
145Abnormal foot bone ossification (HP:0010675)1.59341794
146Asymmetry of the thorax (HP:0001555)1.59306838
147Abnormality of the phalanges of the hallux (HP:0010057)1.58744281
148Abnormal auditory evoked potentials (HP:0006958)1.58493757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.19016337
2CDC74.51282418
3WEE14.13104523
4NEK23.65783144
5TTK2.99077004
6EIF2AK12.77818778
7NEK12.61893976
8CDK122.46325488
9BRSK22.38805896
10PLK12.32181219
11SRPK12.06140287
12AURKB2.03944482
13PLK41.91819799
14SMG11.86125360
15MKNK11.85433779
16PLK31.80542054
17STK101.78739880
18TLK11.77898102
19VRK21.74004017
20EEF2K1.73194615
21CDK71.70633158
22MST1R1.69460049
23CHEK21.66222365
24BRSK11.63597828
25TESK21.62723139
26ATR1.60485922
27MAP3K81.59048515
28PASK1.55614288
29STK41.54688088
30CDK41.44289214
31TSSK61.42530098
32RPS6KB21.41676427
33MKNK21.40436256
34ACVR1B1.39594936
35AURKA1.38324378
36CHEK11.35968628
37ICK1.32805667
38RPS6KA41.28288273
39TAF11.28066628
40MAP3K101.23882670
41PAK41.22091864
42PKN21.21798609
43DYRK31.20407366
44MELK1.19747208
45CDK61.19013028
46STK31.15875779
47VRK11.14107211
48CCNB11.12597942
49MET1.08018696
50PNCK1.07355635
51ATM1.03038482
52LATS11.02422042
53NME20.99932817
54BRD40.96376235
55TGFBR10.94139981
56* CDK20.91191468
57EIF2AK30.89731207
58EPHA20.88753085
59PBK0.88053132
60SCYL20.87411569
61IRAK30.87247248
62ZAK0.85872415
63ALK0.83907224
64ERBB40.79281418
65* CDK10.78710013
66LATS20.74290270
67PIM10.69830431
68EIF2AK20.68130455
69PAK10.68118368
70NEK90.64451389
71TRIB30.60855846
72PTK20.60750386
73CLK10.59267545
74FLT30.58884252
75TESK10.58619038
76STK38L0.58597299
77CDK80.57831955
78LRRK20.57589958
79MTOR0.55729775
80CDK90.54131882
81TRIM280.52527155
82MST40.51068834
83TTN0.50157742
84CSNK2A10.49970289
85CSNK2A20.48485938
86BRAF0.41995684
87AKT20.41518029
88PRKDC0.39605244
89MARK30.38880652
90RPS6KA50.38160614
91PAK20.37582453
92PRKCI0.37512297
93KSR10.36560474
94RAF10.34522629
95* MAPK140.29775455
96KSR20.29539147
97PDGFRA0.29185433
98FGFR10.28539188
99CSNK1E0.27788039
100CSNK1D0.27168057
101DYRK1B0.27152272
102AKT10.26658175
103STK160.26534738
104PDK20.26283351
105CDK150.24489627
106CDK11A0.24312658
107MAP3K90.24155576
108BMX0.23834103
109ERBB20.22820007
110ILK0.22025276
111CDK180.22008596
112BCR0.21933678
113* MAPK10.21677914
114LIMK10.21174975
115CDK140.20783682
116MAPKAPK20.18775258
117* GSK3B0.17839178
118MAPK110.16817455

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63865638
2Mismatch repair_Homo sapiens_hsa034304.07277684
3Cell cycle_Homo sapiens_hsa041103.55440504
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27712840
5Spliceosome_Homo sapiens_hsa030403.26970530
6RNA transport_Homo sapiens_hsa030133.24678138
7Homologous recombination_Homo sapiens_hsa034403.09986482
8Base excision repair_Homo sapiens_hsa034102.99953933
9Nucleotide excision repair_Homo sapiens_hsa034202.74378162
10One carbon pool by folate_Homo sapiens_hsa006702.72784412
11Fanconi anemia pathway_Homo sapiens_hsa034602.59060514
12Ribosome_Homo sapiens_hsa030102.37452832
13RNA polymerase_Homo sapiens_hsa030202.33940017
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22566776
15mRNA surveillance pathway_Homo sapiens_hsa030152.14705889
16p53 signaling pathway_Homo sapiens_hsa041152.05125208
17Non-homologous end-joining_Homo sapiens_hsa034502.03275012
18Basal transcription factors_Homo sapiens_hsa030221.88754355
19Proteasome_Homo sapiens_hsa030501.87513991
20RNA degradation_Homo sapiens_hsa030181.86670329
21Pyrimidine metabolism_Homo sapiens_hsa002401.85322730
22Systemic lupus erythematosus_Homo sapiens_hsa053221.81726968
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76231957
24Oocyte meiosis_Homo sapiens_hsa041141.55096670
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49053265
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39620285
27Viral carcinogenesis_Homo sapiens_hsa052031.38688714
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33801973
29MicroRNAs in cancer_Homo sapiens_hsa052061.26220892
30Epstein-Barr virus infection_Homo sapiens_hsa051691.20830194
31Herpes simplex infection_Homo sapiens_hsa051681.07241679
32HTLV-I infection_Homo sapiens_hsa051661.06944024
33Pyruvate metabolism_Homo sapiens_hsa006201.04688955
34Small cell lung cancer_Homo sapiens_hsa052221.03415255
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95095500
36N-Glycan biosynthesis_Homo sapiens_hsa005100.92843422
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92035834
38Purine metabolism_Homo sapiens_hsa002300.89327501
39Hippo signaling pathway_Homo sapiens_hsa043900.88974786
40Antigen processing and presentation_Homo sapiens_hsa046120.87337529
41Steroid biosynthesis_Homo sapiens_hsa001000.86496059
42Basal cell carcinoma_Homo sapiens_hsa052170.85928354
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85399791
44Thyroid cancer_Homo sapiens_hsa052160.85172602
45Vitamin B6 metabolism_Homo sapiens_hsa007500.83287813
46TGF-beta signaling pathway_Homo sapiens_hsa043500.80672798
47Chronic myeloid leukemia_Homo sapiens_hsa052200.79155336
48Alcoholism_Homo sapiens_hsa050340.77276231
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77094101
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75419172
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75051723
52Bladder cancer_Homo sapiens_hsa052190.74192940
53Colorectal cancer_Homo sapiens_hsa052100.70649949
54Adherens junction_Homo sapiens_hsa045200.67851525
55Selenocompound metabolism_Homo sapiens_hsa004500.67080580
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66195467
57Biosynthesis of amino acids_Homo sapiens_hsa012300.64171855
58Apoptosis_Homo sapiens_hsa042100.60240277
59Fatty acid elongation_Homo sapiens_hsa000620.59949038
60Pentose phosphate pathway_Homo sapiens_hsa000300.59842147
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.59260623
62Hedgehog signaling pathway_Homo sapiens_hsa043400.59047903
63Notch signaling pathway_Homo sapiens_hsa043300.58702704
64Hepatitis B_Homo sapiens_hsa051610.58217528
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54481059
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54116992
67Viral myocarditis_Homo sapiens_hsa054160.53997714
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52900419
69Prostate cancer_Homo sapiens_hsa052150.50720092
70Fructose and mannose metabolism_Homo sapiens_hsa000510.50338581
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50021454
72Pathways in cancer_Homo sapiens_hsa052000.49946338
73Legionellosis_Homo sapiens_hsa051340.49286448
74Proteoglycans in cancer_Homo sapiens_hsa052050.48631024
75Shigellosis_Homo sapiens_hsa051310.47707613
76Pancreatic cancer_Homo sapiens_hsa052120.46456382
77Lysine degradation_Homo sapiens_hsa003100.46109200
78Non-small cell lung cancer_Homo sapiens_hsa052230.45688117
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.44307199
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.42907473
81Protein export_Homo sapiens_hsa030600.42691690
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42602335
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42345054
84mTOR signaling pathway_Homo sapiens_hsa041500.42260720
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41936795
86Galactose metabolism_Homo sapiens_hsa000520.41776682
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41632976
88Melanoma_Homo sapiens_hsa052180.39899431
89HIF-1 signaling pathway_Homo sapiens_hsa040660.39127282
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38452831
91Measles_Homo sapiens_hsa051620.36252916
92Tight junction_Homo sapiens_hsa045300.35720287
93FoxO signaling pathway_Homo sapiens_hsa040680.35601771
94Wnt signaling pathway_Homo sapiens_hsa043100.35208552
95Renal cell carcinoma_Homo sapiens_hsa052110.33335209
96Endometrial cancer_Homo sapiens_hsa052130.32727966
97Influenza A_Homo sapiens_hsa051640.31660322
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.31477188
99Primary immunodeficiency_Homo sapiens_hsa053400.30073276
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.29124571
101AMPK signaling pathway_Homo sapiens_hsa041520.28352124
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.28221668
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26921775
104ErbB signaling pathway_Homo sapiens_hsa040120.26654209
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26570477
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26056921
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26052210
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25912886
109Focal adhesion_Homo sapiens_hsa045100.25706685
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24419204
111Acute myeloid leukemia_Homo sapiens_hsa052210.23717343
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22666624
113ECM-receptor interaction_Homo sapiens_hsa045120.22188979
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22093057
115Folate biosynthesis_Homo sapiens_hsa007900.22077312
116Fatty acid metabolism_Homo sapiens_hsa012120.21896603
117Glutathione metabolism_Homo sapiens_hsa004800.21111234
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20968418
119Hematopoietic cell lineage_Homo sapiens_hsa046400.20904543
120Sulfur relay system_Homo sapiens_hsa041220.20646400
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19315045
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18466535
123Carbon metabolism_Homo sapiens_hsa012000.17268804
124Glioma_Homo sapiens_hsa052140.16898383

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