TPTE2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.27843249
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.94037015
3regulation of cilium movement (GO:0003352)4.17629135
4nonmotile primary cilium assembly (GO:0035058)4.05759939
5epithelial cilium movement (GO:0003351)4.03343553
6pyrimidine nucleobase catabolic process (GO:0006208)3.72043593
7negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56449783
8water-soluble vitamin biosynthetic process (GO:0042364)3.49225778
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42487096
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.41953773
11NADH dehydrogenase complex assembly (GO:0010257)3.41953773
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41953773
13response to pheromone (GO:0019236)3.40828722
14DNA deamination (GO:0045006)3.39878797
15cellular ketone body metabolic process (GO:0046950)3.38381784
16protein complex biogenesis (GO:0070271)3.27915085
17postsynaptic membrane organization (GO:0001941)3.26653505
18establishment of mitochondrion localization (GO:0051654)3.26547364
19gamma-aminobutyric acid transport (GO:0015812)3.24270780
20ubiquinone biosynthetic process (GO:0006744)3.23242642
21cilium movement (GO:0003341)3.23113912
22regulation of microtubule-based movement (GO:0060632)3.22880191
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15330760
24neuronal action potential propagation (GO:0019227)3.12736890
25C4-dicarboxylate transport (GO:0015740)3.11801347
26presynaptic membrane assembly (GO:0097105)3.09834073
27mitochondrial respiratory chain complex assembly (GO:0033108)3.09659679
28ketone body metabolic process (GO:1902224)3.07989080
29nucleobase catabolic process (GO:0046113)3.06032997
30presynaptic membrane organization (GO:0097090)3.04804276
31ubiquinone metabolic process (GO:0006743)3.04259472
32neuron cell-cell adhesion (GO:0007158)3.01619064
33short-term memory (GO:0007614)2.99759654
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96541794
35protein polyglutamylation (GO:0018095)2.95082269
36fucose catabolic process (GO:0019317)2.94353769
37L-fucose metabolic process (GO:0042354)2.94353769
38L-fucose catabolic process (GO:0042355)2.94353769
39sequestering of actin monomers (GO:0042989)2.90418140
40somatic hypermutation of immunoglobulin genes (GO:0016446)2.90250150
41somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90250150
42cilium morphogenesis (GO:0060271)2.87241533
43mitochondrion transport along microtubule (GO:0047497)2.87237598
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87237598
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84916595
46mannosylation (GO:0097502)2.84091717
47proline transport (GO:0015824)2.83684383
48behavioral response to ethanol (GO:0048149)2.83002936
49transmission of nerve impulse (GO:0019226)2.82701702
50preassembly of GPI anchor in ER membrane (GO:0016254)2.80690084
51indolalkylamine metabolic process (GO:0006586)2.76245315
52energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74475533
53ATP synthesis coupled proton transport (GO:0015986)2.74475533
54negative regulation of telomere maintenance (GO:0032205)2.73403875
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72918135
56neuronal action potential (GO:0019228)2.72903949
57auditory receptor cell stereocilium organization (GO:0060088)2.66244422
58inner ear receptor stereocilium organization (GO:0060122)2.65036758
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64960156
60startle response (GO:0001964)2.63115019
61cilium organization (GO:0044782)2.62873258
62cilium assembly (GO:0042384)2.62304546
63detection of mechanical stimulus involved in sensory perception (GO:0050974)2.60486080
64amino acid salvage (GO:0043102)2.60052973
65L-methionine salvage (GO:0071267)2.60052973
66L-methionine biosynthetic process (GO:0071265)2.60052973
67respiratory chain complex IV assembly (GO:0008535)2.58861570
68somite rostral/caudal axis specification (GO:0032525)2.56813117
69axonemal dynein complex assembly (GO:0070286)2.56760716
70positive regulation of mitochondrial fission (GO:0090141)2.55787988
71protein neddylation (GO:0045116)2.54849877
72reflex (GO:0060004)2.53477811
73serotonin metabolic process (GO:0042428)2.51244096
74DNA double-strand break processing (GO:0000729)2.50672064
75piRNA metabolic process (GO:0034587)2.50630915
76axoneme assembly (GO:0035082)2.50512676
77quinone biosynthetic process (GO:1901663)2.50054743
78urinary tract smooth muscle contraction (GO:0014848)2.49936894
79membrane depolarization during action potential (GO:0086010)2.48561209
80glycosphingolipid biosynthetic process (GO:0006688)2.48267801
81photoreceptor cell maintenance (GO:0045494)2.48242567
82serotonin receptor signaling pathway (GO:0007210)2.48054677
83positive regulation of guanylate cyclase activity (GO:0031284)2.47797700
84regulation of timing of cell differentiation (GO:0048505)2.46652785
85primary amino compound metabolic process (GO:1901160)2.46153996
86synaptic transmission, cholinergic (GO:0007271)2.45768854
87indole-containing compound metabolic process (GO:0042430)2.45611885
88kynurenine metabolic process (GO:0070189)2.44704982
89hindbrain development (GO:0030902)2.44444889
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44139689
91mechanosensory behavior (GO:0007638)2.42568235
92sulfation (GO:0051923)2.41995416
93neuromuscular synaptic transmission (GO:0007274)2.40768311
94ovulation cycle (GO:0042698)2.40296519
95DNA methylation involved in gamete generation (GO:0043046)2.40025142
96neural tube formation (GO:0001841)2.39476197
97cytochrome complex assembly (GO:0017004)2.38421193
98protein-cofactor linkage (GO:0018065)2.38351806
99glutamate receptor signaling pathway (GO:0007215)2.37825156
100cilium or flagellum-dependent cell motility (GO:0001539)2.37448837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.15385671
2ZNF274_21170338_ChIP-Seq_K562_Hela3.96971380
3VDR_22108803_ChIP-Seq_LS180_Human3.67458321
4GBX2_23144817_ChIP-Seq_PC3_Human3.53340746
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93901921
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59828271
7IGF1R_20145208_ChIP-Seq_DFB_Human2.55161763
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50458516
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25126108
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25096848
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16897722
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08587301
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08560011
14TAF15_26573619_Chip-Seq_HEK293_Human2.08321210
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05521104
16P300_19829295_ChIP-Seq_ESCs_Human1.96613877
17EWS_26573619_Chip-Seq_HEK293_Human1.93356058
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.84662828
19FUS_26573619_Chip-Seq_HEK293_Human1.83600047
20ER_23166858_ChIP-Seq_MCF-7_Human1.79720544
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78846283
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74063583
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68583228
24REST_21632747_ChIP-Seq_MESCs_Mouse1.64401740
25MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61524577
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.57509848
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57006708
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.56947834
29RNF2_27304074_Chip-Seq_NSC_Mouse1.54242148
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53951054
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53779945
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52687528
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50934223
34IRF1_19129219_ChIP-ChIP_H3396_Human1.49811513
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.49606390
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48629308
37SMAD4_21799915_ChIP-Seq_A2780_Human1.48183040
38CBP_20019798_ChIP-Seq_JUKART_Human1.46421425
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46421425
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44241936
41BCAT_22108803_ChIP-Seq_LS180_Human1.41432985
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41108966
43STAT3_23295773_ChIP-Seq_U87_Human1.40081384
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.39981664
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.39860412
46TP53_22573176_ChIP-Seq_HFKS_Human1.39762941
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38688915
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38193391
49MYC_18940864_ChIP-ChIP_HL60_Human1.38036339
50AR_25329375_ChIP-Seq_VCAP_Human1.37795163
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37637586
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37637586
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37540413
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35486978
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34119762
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32272090
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29456894
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.29096274
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.29052639
60TCF4_23295773_ChIP-Seq_U87_Human1.28778848
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28304452
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.25730170
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25266534
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.24426755
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22474614
66NANOG_19829295_ChIP-Seq_ESCs_Human1.21768897
67SOX2_19829295_ChIP-Seq_ESCs_Human1.21768897
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20113033
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19961080
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16657355
71AR_21572438_ChIP-Seq_LNCaP_Human1.13619672
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.13146725
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11880187
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11647655
75RUNX2_22187159_ChIP-Seq_PCA_Human1.11305819
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10176113
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09998986
78TCF4_22108803_ChIP-Seq_LS180_Human1.09180928
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.08746069
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08255678
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07872095
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07326817
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.07326817
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05980205
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.04324390
86NCOR_22424771_ChIP-Seq_293T_Human1.01214108
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.00935216
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00546545
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.00183363
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.99946591
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99877021
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.99215571
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.97118963
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.96216030
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94965270
96SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94895541
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94758530
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94038500
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93606070
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92430900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.11177515
2MP0008877_abnormal_DNA_methylation2.80003970
3MP0002102_abnormal_ear_morphology2.71366776
4MP0009046_muscle_twitch2.65214433
5MP0001968_abnormal_touch/_nociception2.59649533
6MP0000569_abnormal_digit_pigmentation2.52102145
7MP0002736_abnormal_nociception_after2.35432064
8MP0004133_heterotaxia2.31800582
9MP0006276_abnormal_autonomic_nervous2.31677621
10MP0003787_abnormal_imprinting2.17699449
11MP0004742_abnormal_vestibular_system2.16919578
12MP0002272_abnormal_nervous_system2.09111296
13MP0002735_abnormal_chemical_nociception2.04245564
14MP0009745_abnormal_behavioral_response2.03367410
15MP0005551_abnormal_eye_electrophysiolog1.95277140
16MP0002938_white_spotting1.94699067
17MP0001984_abnormal_olfaction1.93962798
18MP0004859_abnormal_synaptic_plasticity1.93947534
19MP0006292_abnormal_olfactory_placode1.91291748
20MP0001486_abnormal_startle_reflex1.90750352
21MP0004885_abnormal_endolymph1.89681580
22MP0001529_abnormal_vocalization1.75737448
23MP0003635_abnormal_synaptic_transmissio1.75011959
24MP0003122_maternal_imprinting1.74429522
25MP0002572_abnormal_emotion/affect_behav1.73028952
26MP0004142_abnormal_muscle_tone1.70469950
27MP0001986_abnormal_taste_sensitivity1.68662617
28MP0003646_muscle_fatigue1.67245672
29MP0002064_seizures1.66207621
30MP0008872_abnormal_physiological_respon1.62613791
31MP0001501_abnormal_sleep_pattern1.60972414
32MP0005645_abnormal_hypothalamus_physiol1.58445086
33MP0002067_abnormal_sensory_capabilities1.58124677
34MP0001905_abnormal_dopamine_level1.57102131
35MP0008789_abnormal_olfactory_epithelium1.56684090
36MP0003195_calcinosis1.54167096
37MP0002557_abnormal_social/conspecific_i1.54034813
38MP0005394_taste/olfaction_phenotype1.53851372
39MP0005499_abnormal_olfactory_system1.53851372
40MP0002063_abnormal_learning/memory/cond1.53171331
41MP0001485_abnormal_pinna_reflex1.53114512
42MP0005646_abnormal_pituitary_gland1.52488240
43MP0008875_abnormal_xenobiotic_pharmacok1.50382838
44MP0002638_abnormal_pupillary_reflex1.50360050
45MP0004147_increased_porphyrin_level1.49678377
46MP0000566_synostosis1.49439392
47MP0003718_maternal_effect1.49229608
48MP0005187_abnormal_penis_morphology1.48807322
49MP0000778_abnormal_nervous_system1.45222330
50MP0002733_abnormal_thermal_nociception1.44594202
51MP0004145_abnormal_muscle_electrophysio1.44407971
52MP0001970_abnormal_pain_threshold1.39910576
53MP0000372_irregular_coat_pigmentation1.38615952
54MP0002734_abnormal_mechanical_nocicepti1.38016710
55MP0006072_abnormal_retinal_apoptosis1.37616880
56MP0005084_abnormal_gallbladder_morpholo1.34690124
57MP0002234_abnormal_pharynx_morphology1.31979914
58MP0002653_abnormal_ependyma_morphology1.25832981
59MP0003121_genomic_imprinting1.25712064
60MP0005253_abnormal_eye_physiology1.24454306
61MP0002837_dystrophic_cardiac_calcinosis1.18697989
62MP0005386_behavior/neurological_phenoty1.18469058
63MP0004924_abnormal_behavior1.18469058
64MP0000427_abnormal_hair_cycle1.17148982
65MP0002751_abnormal_autonomic_nervous1.13317346
66MP0002184_abnormal_innervation1.11871125
67MP0008995_early_reproductive_senescence1.11454685
68MP0000049_abnormal_middle_ear1.11225870
69MP0005423_abnormal_somatic_nervous1.09265829
70MP0003119_abnormal_digestive_system1.09141140
71MP0002752_abnormal_somatic_nervous1.07941520
72MP0003136_yellow_coat_color1.06958340
73MP0003315_abnormal_perineum_morphology1.05859523
74MP0000631_abnormal_neuroendocrine_gland1.05360131
75MP0008058_abnormal_DNA_repair1.04959628
76MP0000026_abnormal_inner_ear1.03997545
77MP0004043_abnormal_pH_regulation1.02848982
78MP0010386_abnormal_urinary_bladder1.00714770
79MP0001440_abnormal_grooming_behavior0.96100588
80MP0002882_abnormal_neuron_morphology0.95532881
81MP0003890_abnormal_embryonic-extraembry0.94411141
82MP0000955_abnormal_spinal_cord0.90466509
83MP0005167_abnormal_blood-brain_barrier0.89669115
84MP0001963_abnormal_hearing_physiology0.88010794
85MP0005195_abnormal_posterior_eye0.86450963
86MP0003698_abnormal_male_reproductive0.85654300
87MP0002066_abnormal_motor_capabilities/c0.85584442
88MP0002822_catalepsy0.85391844
89MP0005410_abnormal_fertilization0.83927624
90MP0004270_analgesia0.83849578
91MP0003937_abnormal_limbs/digits/tail_de0.82324894
92MP0002229_neurodegeneration0.81519102
93MP0000230_abnormal_systemic_arterial0.80539277
94MP0000383_abnormal_hair_follicle0.79198820
95MP0003567_abnormal_fetal_cardiomyocyte0.76437678
96MP0004215_abnormal_myocardial_fiber0.74147527
97MP0001929_abnormal_gametogenesis0.73632844
98MP0002210_abnormal_sex_determination0.73319870
99MP0005174_abnormal_tail_pigmentation0.71851738
100MP0001293_anophthalmia0.71709941

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.11584911
2True hermaphroditism (HP:0010459)4.05456047
3Pancreatic cysts (HP:0001737)4.03439251
4Abnormality of midbrain morphology (HP:0002418)3.77278369
5Molar tooth sign on MRI (HP:0002419)3.77278369
6Hyperventilation (HP:0002883)3.74950633
7Nephronophthisis (HP:0000090)3.60647742
8Type II lissencephaly (HP:0007260)3.49699210
9Medial flaring of the eyebrow (HP:0010747)3.30441009
10Gait imbalance (HP:0002141)3.23147230
11Methylmalonic acidemia (HP:0002912)3.09212762
12Focal motor seizures (HP:0011153)3.07552618
13Congenital primary aphakia (HP:0007707)3.03203334
14Inability to walk (HP:0002540)2.91440265
15Congenital stationary night blindness (HP:0007642)2.88503135
16Abnormality of the renal medulla (HP:0100957)2.83701329
17Increased hepatocellular lipid droplets (HP:0006565)2.79291152
18Methylmalonic aciduria (HP:0012120)2.70415938
19Nephrogenic diabetes insipidus (HP:0009806)2.70090502
20Lissencephaly (HP:0001339)2.64333705
21Abnormality of the renal cortex (HP:0011035)2.63112280
22Lipid accumulation in hepatocytes (HP:0006561)2.62906335
23Abnormal ciliary motility (HP:0012262)2.60516443
24Abnormal respiratory motile cilium morphology (HP:0005938)2.58793904
25Abnormal respiratory epithelium morphology (HP:0012253)2.58793904
26Retinal dysplasia (HP:0007973)2.58619434
27Renal cortical cysts (HP:0000803)2.57077568
28Genital tract atresia (HP:0001827)2.56192426
29Colon cancer (HP:0003003)2.50927450
30Limb dystonia (HP:0002451)2.50377802
31Acute necrotizing encephalopathy (HP:0006965)2.49591745
32Cystic liver disease (HP:0006706)2.47919512
33Abnormality of the labia minora (HP:0012880)2.45965588
34Progressive inability to walk (HP:0002505)2.45678759
35Cerebellar dysplasia (HP:0007033)2.44676478
36Vaginal atresia (HP:0000148)2.43464494
37Absent/shortened dynein arms (HP:0200106)2.42463630
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.42463630
39Mitochondrial inheritance (HP:0001427)2.41652095
40Birth length less than 3rd percentile (HP:0003561)2.40042210
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.39641752
42Optic nerve hypoplasia (HP:0000609)2.37208991
43Polyphagia (HP:0002591)2.36469988
44Sclerocornea (HP:0000647)2.35046886
45Renal Fanconi syndrome (HP:0001994)2.33517669
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32211400
47Poor coordination (HP:0002370)2.28776910
48Pachygyria (HP:0001302)2.27536763
49Absent speech (HP:0001344)2.26641350
50Increased CSF lactate (HP:0002490)2.26472131
51Concave nail (HP:0001598)2.25848501
52Anencephaly (HP:0002323)2.24813481
53Acute encephalopathy (HP:0006846)2.23847110
54Abnormal mitochondria in muscle tissue (HP:0008316)2.20665663
55Decreased central vision (HP:0007663)2.17307833
56Chronic hepatic failure (HP:0100626)2.17070637
57Abnormal respiratory motile cilium physiology (HP:0012261)2.16824793
58Progressive macrocephaly (HP:0004481)2.16763698
59Progressive cerebellar ataxia (HP:0002073)2.12902291
60Broad-based gait (HP:0002136)2.08610712
61Abnormal number of erythroid precursors (HP:0012131)2.07746637
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07517882
63Male pseudohermaphroditism (HP:0000037)2.03957010
64Postaxial foot polydactyly (HP:0001830)2.02526962
65Patellar aplasia (HP:0006443)2.02516649
66Abnormal rod and cone electroretinograms (HP:0008323)2.01840668
67Rib fusion (HP:0000902)2.00995074
68Hemiparesis (HP:0001269)2.00545379
69Occipital encephalocele (HP:0002085)1.98731330
70Large for gestational age (HP:0001520)1.98620545
71Pendular nystagmus (HP:0012043)1.97869802
72Congenital hepatic fibrosis (HP:0002612)1.96656904
73Febrile seizures (HP:0002373)1.95179548
74Atonic seizures (HP:0010819)1.93005984
75Focal seizures (HP:0007359)1.92775360
76Aplasia/Hypoplasia of the patella (HP:0006498)1.92002133
77Genetic anticipation (HP:0003743)1.86737533
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.85986556
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84494187
80Severe muscular hypotonia (HP:0006829)1.84063156
81Hypothermia (HP:0002045)1.82182972
82Congenital sensorineural hearing impairment (HP:0008527)1.81725580
83Epileptic encephalopathy (HP:0200134)1.81590830
84Keratoconus (HP:0000563)1.81316737
85Increased corneal curvature (HP:0100692)1.81316737
86Polydipsia (HP:0001959)1.80926115
87Abnormal drinking behavior (HP:0030082)1.80926115
88Furrowed tongue (HP:0000221)1.80743844
89Postaxial hand polydactyly (HP:0001162)1.80313564
90Attenuation of retinal blood vessels (HP:0007843)1.79815173
91Hepatocellular necrosis (HP:0001404)1.79552034
92Congenital, generalized hypertrichosis (HP:0004540)1.78420703
93Abnormality of renal resorption (HP:0011038)1.76671194
94Narrow forehead (HP:0000341)1.75837490
95Hyperglycinemia (HP:0002154)1.75381077
96Abnormality of vitamin B metabolism (HP:0004340)1.74899720
97Abnormality of the vitamin B12 metabolism (HP:0004341)1.74084777
98Rhinitis (HP:0012384)1.74042940
99Abolished electroretinogram (ERG) (HP:0000550)1.73919840
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.73783762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.33113408
2CASK3.08627875
3WNK32.93415664
4MAPK132.92260780
5FRK2.91974187
6MAP3K42.59568116
7MARK12.41040231
8BMPR1B2.25322420
9MAP4K22.24572328
10ADRBK22.16520065
11PINK11.97598529
12NUAK11.90008722
13MAP2K71.87149581
14GRK11.84794837
15TLK11.75583793
16DYRK21.75380377
17VRK21.72273362
18NTRK31.71763000
19MAPKAPK51.69655882
20PNCK1.65199482
21ZAK1.61797663
22TAF11.59625950
23NTRK21.57730772
24TNIK1.57066148
25BRSK21.55278310
26INSRR1.53649272
27TAOK31.53319692
28WNK41.48424619
29VRK11.46311423
30EPHA41.45575402
31CSNK1G21.43527837
32ACVR1B1.41491169
33DAPK21.39362475
34PLK41.31895030
35PRKCG1.24869641
36PAK31.22123465
37PTK2B1.12870420
38CSNK1G31.11570678
39NEK21.09022133
40CSNK1G11.08519646
41MAP2K41.07139213
42TSSK61.00593329
43OXSR10.98030565
44PBK0.95337752
45CAMKK20.92359148
46PLK20.91588304
47TGFBR10.90431291
48MAP3K120.90248990
49TXK0.90082312
50PKN10.89497145
51CSNK1A1L0.88279962
52BCKDK0.87075076
53MINK10.86417752
54MKNK20.82836620
55MAPK150.80025300
56NME10.78927193
57WEE10.78339187
58MAPKAPK30.76223299
59ADRBK10.74374602
60MST40.72556912
61PLK30.71568690
62CAMK2A0.71134807
63PHKG20.66484606
64PHKG10.66484606
65GRK50.66237133
66FGFR20.63729795
67DYRK30.62481818
68PRKCE0.62255939
69BCR0.60084407
70CAMK2B0.59365473
71CCNB10.58264578
72TIE10.56862707
73MKNK10.56018848
74STK390.54927550
75LIMK10.53708141
76CDK80.53236413
77DYRK1A0.51571867
78RPS6KA50.50564898
79PAK60.49560644
80PRKACB0.48378480
81TRIM280.48211472
82CSNK1A10.46421172
83PRKACA0.46338069
84PLK10.46082081
85CAMK10.45823387
86CAMK1G0.42451553
87CAMK2D0.40045173
88UHMK10.39058032
89CHEK20.38501993
90STK160.37127286
91PRKG10.35716936
92BUB10.35704130
93CDC70.35159829
94CDK50.34639758
95PRKCQ0.34483424
96SIK20.32062579
97PIK3CA0.30698921
98CAMK40.30617933
99CAMK1D0.29492729
100DAPK10.29465405

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.09179740
2Nicotine addiction_Homo sapiens_hsa050333.05068817
3Oxidative phosphorylation_Homo sapiens_hsa001902.81745526
4Phototransduction_Homo sapiens_hsa047442.59146055
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50331144
6Parkinsons disease_Homo sapiens_hsa050122.44449702
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43590204
8Butanoate metabolism_Homo sapiens_hsa006502.39014427
9Nitrogen metabolism_Homo sapiens_hsa009102.05181735
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90398839
11Linoleic acid metabolism_Homo sapiens_hsa005911.90397165
12Taste transduction_Homo sapiens_hsa047421.76138554
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75927588
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75168087
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73294289
16Protein export_Homo sapiens_hsa030601.70152570
17RNA polymerase_Homo sapiens_hsa030201.63242120
18Huntingtons disease_Homo sapiens_hsa050161.60483573
19Fanconi anemia pathway_Homo sapiens_hsa034601.53969112
20Morphine addiction_Homo sapiens_hsa050321.51022217
21Cardiac muscle contraction_Homo sapiens_hsa042601.49936303
22GABAergic synapse_Homo sapiens_hsa047271.45809065
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43556137
24Basal transcription factors_Homo sapiens_hsa030221.41831110
25Homologous recombination_Homo sapiens_hsa034401.41705549
26Selenocompound metabolism_Homo sapiens_hsa004501.41439136
27Caffeine metabolism_Homo sapiens_hsa002321.39514195
28Ether lipid metabolism_Homo sapiens_hsa005651.39095111
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38997294
30Regulation of autophagy_Homo sapiens_hsa041401.37981581
31Alzheimers disease_Homo sapiens_hsa050101.37752862
32Peroxisome_Homo sapiens_hsa041461.35448289
33Glutamatergic synapse_Homo sapiens_hsa047241.31593193
34Circadian entrainment_Homo sapiens_hsa047131.30363171
35Olfactory transduction_Homo sapiens_hsa047401.30284668
36Propanoate metabolism_Homo sapiens_hsa006401.29757425
37Proteasome_Homo sapiens_hsa030501.27583677
38Tryptophan metabolism_Homo sapiens_hsa003801.23561669
39Sulfur relay system_Homo sapiens_hsa041221.19143694
40Dopaminergic synapse_Homo sapiens_hsa047281.15268287
41Chemical carcinogenesis_Homo sapiens_hsa052041.13303853
42Cocaine addiction_Homo sapiens_hsa050301.13299895
43Fatty acid elongation_Homo sapiens_hsa000621.12723508
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11719719
45Serotonergic synapse_Homo sapiens_hsa047261.11282820
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.08362829
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.06752044
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05518700
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04963005
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04412151
51RNA degradation_Homo sapiens_hsa030181.01997273
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99181584
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97815402
54Steroid biosynthesis_Homo sapiens_hsa001000.90487087
55Amphetamine addiction_Homo sapiens_hsa050310.89386459
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.89005858
57Mismatch repair_Homo sapiens_hsa034300.88566958
58Insulin secretion_Homo sapiens_hsa049110.87615839
59Purine metabolism_Homo sapiens_hsa002300.86276874
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84318062
61Non-homologous end-joining_Homo sapiens_hsa034500.81818610
62Nucleotide excision repair_Homo sapiens_hsa034200.77612574
63Tyrosine metabolism_Homo sapiens_hsa003500.75542998
64Arachidonic acid metabolism_Homo sapiens_hsa005900.75277577
65Synaptic vesicle cycle_Homo sapiens_hsa047210.74679744
66Pyrimidine metabolism_Homo sapiens_hsa002400.73427295
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72766714
68Fat digestion and absorption_Homo sapiens_hsa049750.72597557
69Calcium signaling pathway_Homo sapiens_hsa040200.72469886
70Collecting duct acid secretion_Homo sapiens_hsa049660.68258086
71Metabolic pathways_Homo sapiens_hsa011000.67746718
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66790198
73ABC transporters_Homo sapiens_hsa020100.66753081
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.62466004
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.61699308
76Long-term depression_Homo sapiens_hsa047300.61229242
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61082749
78Retinol metabolism_Homo sapiens_hsa008300.60219123
79Base excision repair_Homo sapiens_hsa034100.58401060
80Ovarian steroidogenesis_Homo sapiens_hsa049130.54372198
81beta-Alanine metabolism_Homo sapiens_hsa004100.52282223
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51994830
83Cholinergic synapse_Homo sapiens_hsa047250.50915775
84Salivary secretion_Homo sapiens_hsa049700.49956954
85Mineral absorption_Homo sapiens_hsa049780.49251114
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49221210
87Dorso-ventral axis formation_Homo sapiens_hsa043200.46917392
88Glutathione metabolism_Homo sapiens_hsa004800.46861445
89Glycerolipid metabolism_Homo sapiens_hsa005610.45535306
90Hedgehog signaling pathway_Homo sapiens_hsa043400.42767034
91Ribosome_Homo sapiens_hsa030100.42317290
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41522210
93Folate biosynthesis_Homo sapiens_hsa007900.41310487
94Fatty acid metabolism_Homo sapiens_hsa012120.40498674
95cAMP signaling pathway_Homo sapiens_hsa040240.39770712
96Gastric acid secretion_Homo sapiens_hsa049710.36748057
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35650678
98One carbon pool by folate_Homo sapiens_hsa006700.35041737
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34135967
100RNA transport_Homo sapiens_hsa030130.33575396

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