TPRX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.19045766
2positive regulation of protein homooligomerization (GO:0032464)5.91052700
3meiosis I (GO:0007127)5.28009324
4regulation of acrosome reaction (GO:0060046)4.49824865
5multicellular organism reproduction (GO:0032504)4.38739941
6regulation of DNA methylation (GO:0044030)4.19153087
7regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.09508517
8negative regulation of retinoic acid receptor signaling pathway (GO:0048387)39.1833017
9regulation of retinoic acid receptor signaling pathway (GO:0048385)32.8981407
10transcription from mitochondrial promoter (GO:0006390)3.85935678
11positive regulation of uterine smooth muscle contraction (GO:0070474)3.69651937
12regulation of cytokine production involved in inflammatory response (GO:1900015)3.62062189
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59984315
14male meiosis (GO:0007140)3.59838712
15rRNA modification (GO:0000154)3.58311386
16regulation of female gonad development (GO:2000194)3.46054858
17regulation of female receptivity (GO:0045924)3.36863224
18aggressive behavior (GO:0002118)3.31937243
19regulation of G0 to G1 transition (GO:0070316)3.22920498
20regulation of protein homooligomerization (GO:0032462)3.18033271
21mitotic metaphase plate congression (GO:0007080)3.17951776
22ventricular cardiac muscle cell development (GO:0055015)3.10916692
23autophagic vacuole assembly (GO:0000045)3.08907807
24rRNA methylation (GO:0031167)3.07318358
25transcription elongation from RNA polymerase III promoter (GO:0006385)2.95043143
26termination of RNA polymerase III transcription (GO:0006386)2.95043143
27activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.90696951
28reproduction (GO:0000003)2.85165747
29snRNA transcription (GO:0009301)2.81785339
30regulation of uterine smooth muscle contraction (GO:0070472)2.81309430
31negative regulation of reproductive process (GO:2000242)2.77252436
32female mating behavior (GO:0060180)2.76422773
33DNA replication checkpoint (GO:0000076)2.73849654
34piRNA metabolic process (GO:0034587)2.71939003
35chaperone mediated protein folding requiring cofactor (GO:0051085)2.71110251
36mitotic chromosome condensation (GO:0007076)2.70846489
37positive regulation of prostaglandin secretion (GO:0032308)2.69768651
38chaperone-mediated protein transport (GO:0072321)2.68374035
39regulation of spindle organization (GO:0090224)2.68053836
40drinking behavior (GO:0042756)2.67018355
41positive regulation of protein oligomerization (GO:0032461)2.64194456
42response to acidic pH (GO:0010447)2.59585129
43glycine transport (GO:0015816)2.59260537
44positive regulation of humoral immune response (GO:0002922)2.58853235
45maturation of SSU-rRNA (GO:0030490)2.56901766
46regulation of penile erection (GO:0060405)2.56884750
47protein K6-linked ubiquitination (GO:0085020)2.56348120
48meiotic cell cycle (GO:0051321)2.56115373
49positive regulation of cAMP-mediated signaling (GO:0043950)2.55802935
50metaphase plate congression (GO:0051310)2.55283625
51protein kinase C signaling (GO:0070528)2.54354540
52meiotic nuclear division (GO:0007126)2.53020096
53oocyte development (GO:0048599)2.52586550
54hyperosmotic salinity response (GO:0042538)2.51218541
55mitochondrial RNA metabolic process (GO:0000959)2.50663334
56skeletal muscle tissue regeneration (GO:0043403)2.49532116
57positive regulation of catecholamine secretion (GO:0033605)2.48974410
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.48305800
59regulation of nuclear cell cycle DNA replication (GO:0033262)2.44870879
60transcription from RNA polymerase III promoter (GO:0006383)2.42327458
61regulation of mitotic spindle organization (GO:0060236)2.40983103
62ribosome assembly (GO:0042255)2.39348491
63detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.37395053
64positive regulation of digestive system process (GO:0060456)2.37359905
65maturation of 5.8S rRNA (GO:0000460)2.35973586
66sleep (GO:0030431)2.31299941
67negative regulation of digestive system process (GO:0060457)2.27900171
68DNA methylation involved in gamete generation (GO:0043046)2.27272799
69meiotic cell cycle process (GO:1903046)2.25902858
70pseudouridine synthesis (GO:0001522)2.25582472
71N-terminal protein amino acid acetylation (GO:0006474)2.25576135
72cellular response to pH (GO:0071467)2.25337169
73attachment of spindle microtubules to kinetochore (GO:0008608)2.22508879
74polyamine biosynthetic process (GO:0006596)2.22024792
75sensory perception of taste (GO:0050909)2.16872426
76telomere maintenance via telomere lengthening (GO:0010833)2.16820414
77rRNA processing (GO:0006364)2.16602126
78single fertilization (GO:0007338)2.14204676
79regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.13185384
80ribosome biogenesis (GO:0042254)2.12724659
81regulation of prostaglandin secretion (GO:0032306)2.11550187
82positive regulation of chromosome segregation (GO:0051984)2.10746677
83rRNA metabolic process (GO:0016072)2.09695076
84maternal behavior (GO:0042711)2.07820952
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.07037277
86seminiferous tubule development (GO:0072520)2.06975592
87binding of sperm to zona pellucida (GO:0007339)2.04871200
88negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.03471214
89regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.02746118
90oocyte maturation (GO:0001556)2.00654323
91regulation of meiosis I (GO:0060631)2.00610513
92behavioral response to nicotine (GO:0035095)1.98567282
93histone H3-K9 demethylation (GO:0033169)1.97787543
94response to UV-C (GO:0010225)1.97479687
95retinal cone cell development (GO:0046549)1.97229210
96glycerophospholipid catabolic process (GO:0046475)1.95927667
97muscle organ morphogenesis (GO:0048644)1.94619900
98histone mRNA metabolic process (GO:0008334)1.93183105
99sperm-egg recognition (GO:0035036)1.93068388
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 1.88945019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_21737748_ChIP-Seq_TLL_Human5.06743196
2ZNF274_21170338_ChIP-Seq_K562_Hela5.03932062
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.77953129
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.40737591
5EZH2_22144423_ChIP-Seq_EOC_Human4.35287398
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.18332144
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.18332144
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.18332144
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.49764692
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.42930097
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.13054044
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96949764
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89350267
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.89046163
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81251400
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.69012155
17ETV1_20927104_ChIP-Seq_GIST48_Human2.48044985
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46850032
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.34528063
20RBPJ_21746931_ChIP-Seq_IB4_Human2.32453619
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19265052
22PHF8_20622853_ChIP-Seq_HELA_Human2.10525388
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10485115
24NFYB_21822215_ChIP-Seq_K562_Human2.08553975
25TBL1_22424771_ChIP-Seq_293T_Human2.04868114
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04465458
27MYC_18940864_ChIP-ChIP_HL60_Human2.03643116
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92319250
29GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.91546940
30GATA6_21074721_ChIP-Seq_CACO-2_Human1.89366557
31VDR_23849224_ChIP-Seq_CD4+_Human1.83367944
32CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.79320274
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.75111174
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64550760
35HNFA_21074721_ChIP-Seq_CACO-2_Human1.59795812
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57946257
37IRF1_19129219_ChIP-ChIP_H3396_Human1.56033647
38VDR_22108803_ChIP-Seq_LS180_Human1.53248529
39TP53_22573176_ChIP-Seq_HFKS_Human1.52009372
40KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40235343
41CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.38414725
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37195387
43NFYA_21822215_ChIP-Seq_K562_Human1.36841582
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35122993
45GABP_19822575_ChIP-Seq_HepG2_Human1.26334677
46PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26278132
47E2F7_22180533_ChIP-Seq_HELA_Human1.25382361
48NANOG_20526341_ChIP-Seq_ESCs_Human1.25027273
49RAC3_21632823_ChIP-Seq_H3396_Human1.24179880
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24035857
51LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23798317
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.23060277
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22199866
54TTF2_22483619_ChIP-Seq_HELA_Human1.22066736
55ELK1_19687146_ChIP-ChIP_HELA_Human1.21777317
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19942674
57FOXP3_21729870_ChIP-Seq_TREG_Human1.18160115
58STAT1_20625510_ChIP-Seq_HELA_Human1.14197085
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13299903
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12633558
61NCOR_22424771_ChIP-Seq_293T_Human1.12445922
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08435908
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06843542
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04704365
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04405322
66E2F1_20622854_ChIP-Seq_HELA_Human1.04175533
67CTCF_20526341_ChIP-Seq_ESCs_Human1.03272821
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.02499042
69HOXB7_26014856_ChIP-Seq_BT474_Human1.01697761
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00700931
71RNF2_27304074_Chip-Seq_NSC_Mouse0.99655593
72MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99332469
73XRN2_22483619_ChIP-Seq_HELA_Human0.94525428
74ERA_21632823_ChIP-Seq_H3396_Human0.94485109
75GATA3_26560356_Chip-Seq_TH2_Human0.92851253
76ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91589826
77NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91520271
78SOX2_21211035_ChIP-Seq_LN229_Human0.91313517
79P53_21459846_ChIP-Seq_SAOS-2_Human0.90208388
80MYC_19829295_ChIP-Seq_ESCs_Human0.90101685
81CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90042628
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88938177
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.88680585
84IGF1R_20145208_ChIP-Seq_DFB_Human0.88177226
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87617166
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.87470573
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85533380
88* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85068486
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84946388
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81606855
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.80599296
92REST_21632747_ChIP-Seq_MESCs_Mouse0.80532622
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.79453550
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.78702296
95CIITA_25753668_ChIP-Seq_RAJI_Human0.78700835
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.77879521
97NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77413790
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.76759170
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75350969
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74540769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity7.00649446
2MP0005423_abnormal_somatic_nervous5.48608932
3MP0006292_abnormal_olfactory_placode4.86691430
4MP0003718_maternal_effect3.96396083
5MP0009379_abnormal_foot_pigmentation3.19846717
6MP0003693_abnormal_embryo_hatching2.89285133
7MP0002138_abnormal_hepatobiliary_system2.77324469
8MP0008877_abnormal_DNA_methylation2.46646399
9MP0002277_abnormal_respiratory_mucosa2.42433203
10MP0002127_abnormal_cardiovascular_syste2.38149122
11MP0005499_abnormal_olfactory_system2.33145175
12MP0005394_taste/olfaction_phenotype2.33145175
13MP0002160_abnormal_reproductive_system2.28181571
14MP0003136_yellow_coat_color2.12540496
15MP0001929_abnormal_gametogenesis2.07280868
16MP0003646_muscle_fatigue2.06269314
17MP0002210_abnormal_sex_determination2.03160568
18MP0000372_irregular_coat_pigmentation1.99551948
19MP0003195_calcinosis1.97229639
20MP0010307_abnormal_tumor_latency1.92604646
21MP0006276_abnormal_autonomic_nervous1.90661938
22MP0005410_abnormal_fertilization1.86942579
23MP0003111_abnormal_nucleus_morphology1.83469346
24MP0009333_abnormal_splenocyte_physiolog1.79823692
25MP0005389_reproductive_system_phenotype1.79038757
26MP0008058_abnormal_DNA_repair1.75762318
27MP0005647_abnormal_sex_gland1.68187846
28MP0004957_abnormal_blastocyst_morpholog1.64721037
29MP0003938_abnormal_ear_development1.56820362
30MP0005395_other_phenotype1.49257280
31MP0008789_abnormal_olfactory_epithelium1.48546754
32MP0003077_abnormal_cell_cycle1.44935583
33MP0000653_abnormal_sex_gland1.43927530
34MP0010094_abnormal_chromosome_stability1.43004724
35MP0001968_abnormal_touch/_nociception1.35153179
36MP0003699_abnormal_female_reproductive1.34945609
37MP0003698_abnormal_male_reproductive1.34151314
38MP0002735_abnormal_chemical_nociception1.33220496
39MP0008260_abnormal_autophagy1.31482312
40MP0005646_abnormal_pituitary_gland1.30101544
41MP0001145_abnormal_male_reproductive1.25758956
42MP0002161_abnormal_fertility/fecundity1.24105881
43MP0001881_abnormal_mammary_gland1.21548711
44MP0008995_early_reproductive_senescence1.19076013
45MP0000015_abnormal_ear_pigmentation1.18649294
46MP0010030_abnormal_orbit_morphology1.16752705
47MP0000049_abnormal_middle_ear1.16378996
48MP0002254_reproductive_system_inflammat1.07762551
49MP0005360_urolithiasis1.07672251
50MP0006036_abnormal_mitochondrial_physio1.07059420
51MP0000631_abnormal_neuroendocrine_gland1.03548468
52MP0004142_abnormal_muscle_tone1.02882789
53MP0003567_abnormal_fetal_cardiomyocyte1.00659114
54MP0002234_abnormal_pharynx_morphology1.00570122
55MP0001502_abnormal_circadian_rhythm0.99137467
56MP0005551_abnormal_eye_electrophysiolog0.97017570
57MP0001119_abnormal_female_reproductive0.95213295
58MP0001293_anophthalmia0.92809695
59MP0004215_abnormal_myocardial_fiber0.90008018
60MP0001919_abnormal_reproductive_system0.88451745
61MP0001672_abnormal_embryogenesis/_devel0.88058098
62MP0005380_embryogenesis_phenotype0.88058098
63MP0000569_abnormal_digit_pigmentation0.87687462
64MP0002163_abnormal_gland_morphology0.84228982
65MP0002095_abnormal_skin_pigmentation0.82843216
66MP0009840_abnormal_foam_cell0.82034986
67MP0004019_abnormal_vitamin_homeostasis0.81804394
68MP0005174_abnormal_tail_pigmentation0.80565948
69MP0001666_abnormal_nutrient_absorption0.78106962
70MP0002233_abnormal_nose_morphology0.75628782
71MP0000750_abnormal_muscle_regeneration0.72190401
72MP0003121_genomic_imprinting0.71350848
73MP0001286_abnormal_eye_development0.70935342
74MP0003936_abnormal_reproductive_system0.68931150
75MP0008057_abnormal_DNA_replication0.68519450
76MP0008932_abnormal_embryonic_tissue0.68271740
77MP0003119_abnormal_digestive_system0.68269709
78MP0003283_abnormal_digestive_organ0.67064237
79MP0003984_embryonic_growth_retardation0.66536637
80MP0002734_abnormal_mechanical_nocicepti0.65788358
81MP0000350_abnormal_cell_proliferation0.65473695
82MP0002088_abnormal_embryonic_growth/wei0.64436745
83MP0002873_normal_phenotype0.63438788
84MP0002169_no_abnormal_phenotype0.62934892
85MP0003880_abnormal_central_pattern0.61908788
86MP0001188_hyperpigmentation0.60808991
87MP0001485_abnormal_pinna_reflex0.59695383
88MP0001697_abnormal_embryo_size0.58017549
89MP0002102_abnormal_ear_morphology0.57851635
90MP0005220_abnormal_exocrine_pancreas0.57509373
91MP0000427_abnormal_hair_cycle0.57400813
92MP0002751_abnormal_autonomic_nervous0.56365665
93MP0005645_abnormal_hypothalamus_physiol0.55726758
94MP0000647_abnormal_sebaceous_gland0.55657384
95MP0005379_endocrine/exocrine_gland_phen0.54599543
96MP0009046_muscle_twitch0.53768456
97MP0000490_abnormal_crypts_of0.53671050
98MP0001764_abnormal_homeostasis0.53309901
99MP0001730_embryonic_growth_arrest0.52932203
100MP0002876_abnormal_thyroid_physiology0.52164558

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.30809613
2Aplasia/hypoplasia of the uterus (HP:0008684)4.68248232
3Birth length less than 3rd percentile (HP:0003561)4.07553680
4Hypoplasia of the uterus (HP:0000013)3.89543163
5Carpal bone hypoplasia (HP:0001498)3.75182422
6Patent foramen ovale (HP:0001655)3.69009638
7Premature ovarian failure (HP:0008209)3.65473958
8Hypercortisolism (HP:0001578)3.55178363
9Double outlet right ventricle (HP:0001719)3.35449392
10Congenital malformation of the right heart (HP:0011723)3.35449392
11Malnutrition (HP:0004395)3.25404101
12Ureteral duplication (HP:0000073)3.20624323
13Abnormality of the aortic arch (HP:0012303)3.17907060
14Aplasia/Hypoplasia involving the musculature (HP:0001460)3.11485437
15Pendular nystagmus (HP:0012043)3.03140585
16Preauricular pit (HP:0004467)2.98895846
17Periauricular skin pits (HP:0100277)2.98895846
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.96216058
19Constricted visual fields (HP:0001133)2.95155275
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92179200
21Short tibia (HP:0005736)2.87969690
22Concave nail (HP:0001598)2.87225301
23Impulsivity (HP:0100710)2.86754125
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.81057886
25Pancreatic cysts (HP:0001737)2.79023891
26Infertility (HP:0000789)2.77515861
27Hypophosphatemic rickets (HP:0004912)2.77201641
28Abnormal pancreas size (HP:0012094)2.77007797
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.76502368
30Molar tooth sign on MRI (HP:0002419)2.68004074
31Abnormality of midbrain morphology (HP:0002418)2.68004074
32Hypoplasia of the fovea (HP:0007750)2.67347305
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.67347305
34Fused cervical vertebrae (HP:0002949)2.66761069
35Reticulocytopenia (HP:0001896)2.56011929
36Abnormal respiratory epithelium morphology (HP:0012253)2.53469495
37Abnormal respiratory motile cilium morphology (HP:0005938)2.53469495
38Abnormality of the septum pellucidum (HP:0007375)2.48839568
39Meckel diverticulum (HP:0002245)2.48776941
40Attenuation of retinal blood vessels (HP:0007843)2.48495840
41Abnormal rod and cone electroretinograms (HP:0008323)2.45326079
42Abnormality of the ileum (HP:0001549)2.42372620
43Rhinitis (HP:0012384)2.42199537
44Abnormality of the fovea (HP:0000493)2.40290647
45Hypergonadotropic hypogonadism (HP:0000815)2.40068798
46Limb dystonia (HP:0002451)2.37520659
47Anhidrosis (HP:0000970)2.35989299
48Absent radius (HP:0003974)2.34518292
49Aplasia/hypoplasia of the humerus (HP:0006507)2.33949219
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.32919111
51Absent/shortened dynein arms (HP:0200106)2.32919111
52Absent forearm bone (HP:0003953)2.30485759
53Aplasia involving forearm bones (HP:0009822)2.30485759
54Microretrognathia (HP:0000308)2.29760114
55Absent thumb (HP:0009777)2.28262435
56Pancreatic fibrosis (HP:0100732)2.24739269
57Stenosis of the external auditory canal (HP:0000402)2.23522346
58Delayed CNS myelination (HP:0002188)2.23142558
59Anterior segment dysgenesis (HP:0007700)2.21826428
60Abnormality of the fetal cardiovascular system (HP:0010948)2.21544702
61Abnormal umbilical cord blood vessels (HP:0011403)2.21544702
62Single umbilical artery (HP:0001195)2.21544702
63Type 2 muscle fiber atrophy (HP:0003554)2.20781926
64Decreased central vision (HP:0007663)2.19851063
65Horseshoe kidney (HP:0000085)2.19580949
66Abnormal number of erythroid precursors (HP:0012131)2.15490222
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.13521541
68Abnormal ciliary motility (HP:0012262)2.10116613
69Abnormality of cells of the erythroid lineage (HP:0012130)2.09324122
70Supernumerary spleens (HP:0009799)2.09163794
71Male pseudohermaphroditism (HP:0000037)2.08527066
72Absent septum pellucidum (HP:0001331)2.07448106
73Adrenal overactivity (HP:0002717)2.07276308
74Abnormality of the preputium (HP:0100587)2.06473934
75Chronic sinusitis (HP:0011109)2.05476780
76Congenital stationary night blindness (HP:0007642)2.04415535
77Abnormality of the renal collecting system (HP:0004742)2.03884037
78Sensory axonal neuropathy (HP:0003390)2.01386622
79Septo-optic dysplasia (HP:0100842)2.01104326
80Muscle stiffness (HP:0003552)1.97124848
81Type II lissencephaly (HP:0007260)1.95403875
82Myokymia (HP:0002411)1.95325715
83Stomatitis (HP:0010280)1.95037923
84Abdominal situs inversus (HP:0003363)1.94700149
85Abnormality of abdominal situs (HP:0011620)1.94700149
86Hyperglycemia (HP:0003074)1.93156442
87Duplicated collecting system (HP:0000081)1.93053423
88Multiple enchondromatosis (HP:0005701)1.92629511
89Severe visual impairment (HP:0001141)1.91793207
90Cleft eyelid (HP:0000625)1.91764414
91Severe muscular hypotonia (HP:0006829)1.91222577
92Azoospermia (HP:0000027)1.90325599
93Fibular aplasia (HP:0002990)1.88971737
94True hermaphroditism (HP:0010459)1.88663573
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87497339
96Ectopic kidney (HP:0000086)1.87169106
97Hypoglycemic seizures (HP:0002173)1.86425411
98Gonadotropin excess (HP:0000837)1.85673859
99Chronic otitis media (HP:0000389)1.83125799
100Midline defect of the nose (HP:0004122)1.82031493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.97923444
2BUB14.03932416
3SRPK13.75856824
4STK163.67453209
5LATS22.92471289
6BMPR1B2.76941019
7TRIM282.69639104
8CDK192.54397158
9BRSK22.38224556
10ZAK2.16989515
11BRSK12.07731308
12PLK12.06795528
13PLK32.01619923
14WNK32.01049606
15NEK62.00028911
16TLK11.89605369
17INSRR1.78440889
18TAOK31.73875393
19DYRK31.65351665
20NUAK11.60968391
21CDK91.58643479
22MAP4K21.57940184
23AURKA1.53786370
24PDK21.48340422
25NEK21.40990751
26GRK11.39766237
27ADRBK21.38267904
28CDK71.34685525
29AURKB1.30996078
30NTRK31.25965482
31STK31.22516210
32CDK81.22336151
33FRK1.14547528
34MAP3K41.09390392
35CDC71.07639733
36TGFBR11.05319615
37PKN11.04866792
38PLK41.03851141
39CHEK11.03780070
40MARK31.03354185
41CHEK21.01945553
42GSK3A1.00486053
43PRKCI0.91067385
44CSNK1E0.87092015
45VRK10.86467284
46MAP3K50.86220883
47PIM10.84979564
48CSNK2A10.80900975
49WNK10.80416148
50ATR0.80162721
51CAMKK20.79667027
52CSNK1A10.75575859
53NME10.72703714
54PIM20.72034343
55CASK0.71152382
56CSNK2A20.68854359
57KDR0.67510752
58TEC0.65187660
59MAPK130.64039975
60PRKCE0.63596841
61BMX0.62256511
62PAK10.61854532
63ACVR1B0.60033758
64CDK30.55176067
65CDK20.53301410
66MELK0.53262416
67PRKD20.53194693
68PRKACB0.52424608
69PAK20.52390381
70PRKG10.52370881
71WNK40.52198456
72PRKCG0.51850981
73AKT20.50672182
74PINK10.49044362
75TXK0.47057916
76PLK20.46255421
77CDK10.44629275
78STK240.42388809
79PAK60.42203816
80BMPR20.41469679
81ATM0.40596786
82TTK0.39554813
83ADRBK10.39215535
84PRKACA0.39003486
85STK38L0.37632916
86CAMK10.36774080
87DYRK1A0.36383544
88MAP2K70.35826075
89RAF10.32066489
90MAPK10.31378756
91MAP3K90.31108616
92RPS6KA40.31062632
93CAMK40.29361799
94TNIK0.29202007
95CSNK1D0.29021373
96RPS6KA50.28795224
97PRKCA0.28290657
98GSK3B0.27773278
99CAMK1D0.27716968
100PRKCQ0.27714805

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.08801919
2Regulation of autophagy_Homo sapiens_hsa041404.51209725
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.88966557
4RNA polymerase_Homo sapiens_hsa030203.85039605
5Ribosome_Homo sapiens_hsa030103.35395665
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.29711350
7mRNA surveillance pathway_Homo sapiens_hsa030152.83045900
8RNA transport_Homo sapiens_hsa030132.61813902
9Taste transduction_Homo sapiens_hsa047422.27418374
10p53 signaling pathway_Homo sapiens_hsa041152.24306166
11Cell cycle_Homo sapiens_hsa041102.12960036
12Oocyte meiosis_Homo sapiens_hsa041142.03597601
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98215299
14Spliceosome_Homo sapiens_hsa030401.95058163
15RNA degradation_Homo sapiens_hsa030181.84536816
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73177064
17Sulfur metabolism_Homo sapiens_hsa009201.72116343
18Fanconi anemia pathway_Homo sapiens_hsa034601.67818914
19Caffeine metabolism_Homo sapiens_hsa002321.67742253
20Ovarian steroidogenesis_Homo sapiens_hsa049131.62583781
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.54050797
22Homologous recombination_Homo sapiens_hsa034401.52951789
23Folate biosynthesis_Homo sapiens_hsa007901.52911175
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44935767
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42943379
26Pyrimidine metabolism_Homo sapiens_hsa002401.38303324
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26453204
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26312605
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.25972619
30Huntingtons disease_Homo sapiens_hsa050161.21774795
31Linoleic acid metabolism_Homo sapiens_hsa005911.21177084
32Nitrogen metabolism_Homo sapiens_hsa009101.19577818
33Base excision repair_Homo sapiens_hsa034101.15579713
34Dorso-ventral axis formation_Homo sapiens_hsa043201.10349095
35Protein export_Homo sapiens_hsa030601.10042737
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07582599
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06771399
38Parkinsons disease_Homo sapiens_hsa050121.05801018
39Mismatch repair_Homo sapiens_hsa034301.05103291
40Cardiac muscle contraction_Homo sapiens_hsa042601.00320044
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99504341
42Olfactory transduction_Homo sapiens_hsa047400.95688614
43Proteasome_Homo sapiens_hsa030500.91470945
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91319293
45Steroid biosynthesis_Homo sapiens_hsa001000.87394619
46Purine metabolism_Homo sapiens_hsa002300.86137692
47Selenocompound metabolism_Homo sapiens_hsa004500.85970844
48Nicotine addiction_Homo sapiens_hsa050330.83712589
49Oxidative phosphorylation_Homo sapiens_hsa001900.79939276
50Phototransduction_Homo sapiens_hsa047440.75887899
51Insulin secretion_Homo sapiens_hsa049110.72619042
52Ether lipid metabolism_Homo sapiens_hsa005650.65605115
53Asthma_Homo sapiens_hsa053100.56807791
54DNA replication_Homo sapiens_hsa030300.56642022
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55756135
56Epstein-Barr virus infection_Homo sapiens_hsa051690.55619554
57Herpes simplex infection_Homo sapiens_hsa051680.53700843
58ABC transporters_Homo sapiens_hsa020100.52200902
59Fatty acid biosynthesis_Homo sapiens_hsa000610.50536869
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49626361
61Viral carcinogenesis_Homo sapiens_hsa052030.49327580
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46370019
63GABAergic synapse_Homo sapiens_hsa047270.46164394
64Nucleotide excision repair_Homo sapiens_hsa034200.45854911
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45753794
66Serotonergic synapse_Homo sapiens_hsa047260.43441988
67Morphine addiction_Homo sapiens_hsa050320.43231398
68Hedgehog signaling pathway_Homo sapiens_hsa043400.42912114
69Chemical carcinogenesis_Homo sapiens_hsa052040.41646738
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40974253
71Arachidonic acid metabolism_Homo sapiens_hsa005900.39815341
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.38969819
73Arginine and proline metabolism_Homo sapiens_hsa003300.35295655
74Wnt signaling pathway_Homo sapiens_hsa043100.35285892
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34020447
76Primary immunodeficiency_Homo sapiens_hsa053400.30648625
77Vitamin digestion and absorption_Homo sapiens_hsa049770.30417648
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.30411623
79Metabolic pathways_Homo sapiens_hsa011000.28197332
80Sulfur relay system_Homo sapiens_hsa041220.27435104
81Retinol metabolism_Homo sapiens_hsa008300.27279637
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26054719
83Systemic lupus erythematosus_Homo sapiens_hsa053220.23954901
84Collecting duct acid secretion_Homo sapiens_hsa049660.23523534
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22501926
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21716882
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20752877
88TGF-beta signaling pathway_Homo sapiens_hsa043500.20160083
89MicroRNAs in cancer_Homo sapiens_hsa052060.20113313
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17940754
91Fatty acid elongation_Homo sapiens_hsa000620.17714469
92Inositol phosphate metabolism_Homo sapiens_hsa005620.16350181
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15880900
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.13678141
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13524744
96Butanoate metabolism_Homo sapiens_hsa006500.13214879
97Mineral absorption_Homo sapiens_hsa049780.12153126
98Sphingolipid metabolism_Homo sapiens_hsa006000.11672091
99Calcium signaling pathway_Homo sapiens_hsa040200.11162754
100AMPK signaling pathway_Homo sapiens_hsa041520.10910825

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