TPRKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.99994544
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.90167338
3L-phenylalanine catabolic process (GO:0006559)6.90167338
4L-phenylalanine metabolic process (GO:0006558)6.51765835
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51765835
6ATP synthesis coupled proton transport (GO:0015986)6.18841270
7energy coupled proton transport, down electrochemical gradient (GO:0015985)6.18841270
8aromatic amino acid family catabolic process (GO:0009074)6.10892287
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68926178
10viral transcription (GO:0019083)5.56621407
11ribosomal small subunit assembly (GO:0000028)5.48342066
12translational termination (GO:0006415)5.46212158
13tryptophan catabolic process (GO:0006569)5.44273393
14indole-containing compound catabolic process (GO:0042436)5.44273393
15indolalkylamine catabolic process (GO:0046218)5.44273393
16bile acid biosynthetic process (GO:0006699)5.33618167
17establishment of protein localization to mitochondrial membrane (GO:0090151)5.30450754
18chaperone-mediated protein transport (GO:0072321)5.21846937
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.14126324
20alpha-linolenic acid metabolic process (GO:0036109)5.08264859
21tryptophan metabolic process (GO:0006568)5.08093349
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.04762630
23cotranslational protein targeting to membrane (GO:0006613)5.03468749
24kynurenine metabolic process (GO:0070189)5.00272996
25glyoxylate metabolic process (GO:0046487)4.98186351
26protein targeting to ER (GO:0045047)4.94890008
27cysteine metabolic process (GO:0006534)4.88803706
28respiratory electron transport chain (GO:0022904)4.87739574
29high-density lipoprotein particle remodeling (GO:0034375)4.87100727
30low-density lipoprotein particle remodeling (GO:0034374)4.83983387
31ribosomal large subunit biogenesis (GO:0042273)4.82436675
32ribosomal small subunit biogenesis (GO:0042274)4.80059359
33electron transport chain (GO:0022900)4.79554231
34protein neddylation (GO:0045116)4.79503602
35establishment of protein localization to endoplasmic reticulum (GO:0072599)4.76562236
36regulation of cholesterol esterification (GO:0010872)4.75811714
37proteasome assembly (GO:0043248)4.68133547
38protein localization to endoplasmic reticulum (GO:0070972)4.63613399
39translational elongation (GO:0006414)4.56514922
40protein-lipid complex remodeling (GO:0034368)4.52605389
41macromolecular complex remodeling (GO:0034367)4.52605389
42plasma lipoprotein particle remodeling (GO:0034369)4.52605389
43reverse cholesterol transport (GO:0043691)4.52024860
44sulfur amino acid catabolic process (GO:0000098)4.50438079
45bile acid metabolic process (GO:0008206)4.46951809
46glutamate metabolic process (GO:0006536)4.44171701
47aromatic amino acid family metabolic process (GO:0009072)4.43396849
48urea cycle (GO:0000050)4.43327599
49urea metabolic process (GO:0019627)4.43327599
50serine family amino acid catabolic process (GO:0009071)4.42801119
51maturation of SSU-rRNA (GO:0030490)4.42403542
52alpha-amino acid catabolic process (GO:1901606)4.33616766
53chromatin remodeling at centromere (GO:0031055)4.32317344
54homocysteine metabolic process (GO:0050667)4.31432388
55protein complex biogenesis (GO:0070271)4.31256841
56CENP-A containing nucleosome assembly (GO:0034080)4.27952115
57coenzyme catabolic process (GO:0009109)4.24143911
58cellular protein complex disassembly (GO:0043624)4.22814316
59mitochondrial respiratory chain complex assembly (GO:0033108)4.20756178
60amine catabolic process (GO:0009310)4.20290440
61cellular biogenic amine catabolic process (GO:0042402)4.20290440
62translational initiation (GO:0006413)4.19601519
63tyrosine metabolic process (GO:0006570)4.19533681
64viral life cycle (GO:0019058)4.17780134
65regulation of fibrinolysis (GO:0051917)4.17046466
66regulation of protein activation cascade (GO:2000257)4.14510512
67amino-acid betaine metabolic process (GO:0006577)4.14275965
68negative regulation of fibrinolysis (GO:0051918)4.13906650
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12843413
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.12375881
71peptidyl-glutamic acid carboxylation (GO:0017187)4.10799673
72protein carboxylation (GO:0018214)4.10799673
73cellular modified amino acid catabolic process (GO:0042219)4.10299052
74nitrogen cycle metabolic process (GO:0071941)4.06628805
75cellular amino acid catabolic process (GO:0009063)4.06240652
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05090268
77mitochondrial respiratory chain complex I assembly (GO:0032981)4.05090268
78NADH dehydrogenase complex assembly (GO:0010257)4.05090268
79regulation of triglyceride catabolic process (GO:0010896)4.04007179
80cellular ketone body metabolic process (GO:0046950)3.99489567
81complement activation, alternative pathway (GO:0006957)3.99333485
82lysine catabolic process (GO:0006554)3.96839093
83lysine metabolic process (GO:0006553)3.96839093
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.96442638
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.96036992
86dicarboxylic acid biosynthetic process (GO:0043650)3.95358378
87translation (GO:0006412)3.94403977
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.91705306
89short-chain fatty acid metabolic process (GO:0046459)3.90419514
90serine family amino acid biosynthetic process (GO:0009070)3.89863825
91indolalkylamine metabolic process (GO:0006586)3.88086205
92regulation of complement activation (GO:0030449)3.86394824
93phospholipid efflux (GO:0033700)3.84951369
94cellular glucuronidation (GO:0052695)3.80088477
95very-low-density lipoprotein particle assembly (GO:0034379)3.78654397
96negative regulation of cholesterol transport (GO:0032375)3.78345356
97negative regulation of sterol transport (GO:0032372)3.78345356
98serine family amino acid metabolic process (GO:0009069)3.74906269
99very long-chain fatty acid metabolic process (GO:0000038)3.73022438
100establishment of integrated proviral latency (GO:0075713)3.69585094
101triglyceride homeostasis (GO:0070328)3.68715773
102acylglycerol homeostasis (GO:0055090)3.68715773
103cholesterol efflux (GO:0033344)3.67880264
104termination of RNA polymerase III transcription (GO:0006386)3.67463049
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.67463049
106ethanol oxidation (GO:0006069)3.67080489
107regulation of bile acid biosynthetic process (GO:0070857)3.63047537
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62762352
109regulation of mitochondrial translation (GO:0070129)3.60788254
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59802541
111protein complex disassembly (GO:0043241)3.58413581
112imidazole-containing compound metabolic process (GO:0052803)3.57710143
113bile acid and bile salt transport (GO:0015721)3.55651500
114plasma lipoprotein particle assembly (GO:0034377)3.54660707
115rRNA modification (GO:0000154)3.53499432
116plasma lipoprotein particle organization (GO:0071827)3.53238805
117cofactor catabolic process (GO:0051187)3.51936199
118drug catabolic process (GO:0042737)3.51119240
119macromolecular complex disassembly (GO:0032984)3.50346253
120negative regulation of ligase activity (GO:0051352)3.49688860
121negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49688860
122organic acid catabolic process (GO:0016054)3.49534501
123carboxylic acid catabolic process (GO:0046395)3.49534501
124histone exchange (GO:0043486)3.49085571
125benzene-containing compound metabolic process (GO:0042537)3.48446066
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47860527
127ketone body metabolic process (GO:1902224)3.47589416
128aldehyde catabolic process (GO:0046185)3.47300285
129L-serine metabolic process (GO:0006563)3.47220729
130spliceosomal snRNP assembly (GO:0000387)3.45781347
131respiratory chain complex IV assembly (GO:0008535)3.44774028
132dicarboxylic acid catabolic process (GO:0043649)3.44546463
133glycine metabolic process (GO:0006544)3.43950963
134aspartate family amino acid catabolic process (GO:0009068)3.43436804
135glucuronate metabolic process (GO:0019585)3.42354077
136uronic acid metabolic process (GO:0006063)3.42354077
137arginine metabolic process (GO:0006525)3.41623921
138ATP biosynthetic process (GO:0006754)3.39313031
139DNA damage response, detection of DNA damage (GO:0042769)3.38770922
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38375927
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38375927
142cellular component biogenesis (GO:0044085)3.36569011
143regulation of cholesterol biosynthetic process (GO:0045540)3.35718286
144nuclear-transcribed mRNA catabolic process (GO:0000956)3.33950692
145plasma lipoprotein particle clearance (GO:0034381)3.29839628
146oxidative phosphorylation (GO:0006119)3.26822188
147inner mitochondrial membrane organization (GO:0007007)3.26662355
148purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26380378
149protein-lipid complex subunit organization (GO:0071825)3.26282787
150protein targeting to membrane (GO:0006612)3.25998194
151fatty acid elongation (GO:0030497)3.25994614
152cytochrome complex assembly (GO:0017004)3.25454571
153protein targeting to mitochondrion (GO:0006626)3.25157727
154linoleic acid metabolic process (GO:0043651)3.25118918
155ribonucleoprotein complex biogenesis (GO:0022613)3.24372796
156purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23073680
157regulation of cholesterol metabolic process (GO:0090181)3.22590211
158DNA double-strand break processing (GO:0000729)3.21985471
159DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21936831
160hydrogen ion transmembrane transport (GO:1902600)3.21739335
161DNA replication checkpoint (GO:0000076)3.21312486
162signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19152609
163signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19152609
164signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19152609
165drug transmembrane transport (GO:0006855)3.17941130
166heme transport (GO:0015886)3.17888418
167acetyl-CoA metabolic process (GO:0006084)3.17161729
168sequestering of actin monomers (GO:0042989)3.16938977
169kinetochore organization (GO:0051383)3.16509863
170protein localization to mitochondrion (GO:0070585)3.16396880
171regulation of cellular amino acid metabolic process (GO:0006521)3.16267131
172NAD biosynthetic process (GO:0009435)3.16094984
173exogenous drug catabolic process (GO:0042738)3.15441327
174mRNA catabolic process (GO:0006402)3.14861455
175response to nitrosative stress (GO:0051409)3.14732434
176intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14483871
177signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14483871
178carnitine metabolic process (GO:0009437)3.14186432
179DNA replication-independent nucleosome organization (GO:0034724)3.12737319
180DNA replication-independent nucleosome assembly (GO:0006336)3.12737319
181glutamine family amino acid biosynthetic process (GO:0009084)3.12340804
182monocarboxylic acid catabolic process (GO:0072329)3.12326863
183establishment of protein localization to mitochondrion (GO:0072655)3.12012656
184kinetochore assembly (GO:0051382)3.11812506
185positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09175432
186replication fork processing (GO:0031297)3.06759987
187signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06037152
188signal transduction involved in DNA damage checkpoint (GO:0072422)3.06037152
189signal transduction involved in cell cycle checkpoint (GO:0072395)3.05534902
190rRNA processing (GO:0006364)3.05121034
191intracellular protein transmembrane import (GO:0044743)3.04489735
192organelle disassembly (GO:1903008)3.03356906
193regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00697607
194regulation of mitotic spindle checkpoint (GO:1903504)3.00697607
195cullin deneddylation (GO:0010388)2.98810698
196pseudouridine synthesis (GO:0001522)2.97036449
197positive regulation of ligase activity (GO:0051351)2.95692061
198rRNA metabolic process (GO:0016072)2.95501421
199water-soluble vitamin biosynthetic process (GO:0042364)2.94350361
200protein-cofactor linkage (GO:0018065)2.93160000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.57077751
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.88089888
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.39335698
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.27613967
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.81842348
6* GABP_17652178_ChIP-ChIP_JURKAT_Human4.79512234
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.70091176
8* EST1_17652178_ChIP-ChIP_JURKAT_Human4.46541672
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.13474335
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.43525452
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.37762294
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.33411019
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28867483
14* ETS1_20019798_ChIP-Seq_JURKAT_Human3.17264856
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14955359
16* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14785983
17* ELK1_19687146_ChIP-ChIP_HELA_Human3.03258665
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.02000180
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.98531771
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87518549
21E2F7_22180533_ChIP-Seq_HELA_Human2.83183208
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.82509803
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67210169
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58525277
25* VDR_23849224_ChIP-Seq_CD4+_Human2.55881237
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44360217
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39964324
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.23784357
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20669048
30VDR_22108803_ChIP-Seq_LS180_Human2.17192050
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16538790
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15588143
33MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13903093
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09755569
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03069834
36TTF2_22483619_ChIP-Seq_HELA_Human2.02585161
37GBX2_23144817_ChIP-Seq_PC3_Human2.01638526
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98882838
39HTT_18923047_ChIP-ChIP_STHdh_Human1.94829409
40* MYC_18940864_ChIP-ChIP_HL60_Human1.92602691
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.91979690
42* SRF_21415370_ChIP-Seq_HL-1_Mouse1.88553571
43* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86357882
44* XRN2_22483619_ChIP-Seq_HELA_Human1.84081557
45ZNF274_21170338_ChIP-Seq_K562_Hela1.83083385
46DCP1A_22483619_ChIP-Seq_HELA_Human1.81696882
47EWS_26573619_Chip-Seq_HEK293_Human1.79521601
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79321710
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78814386
50FUS_26573619_Chip-Seq_HEK293_Human1.76021106
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74743659
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74282287
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60421075
54* GABP_19822575_ChIP-Seq_HepG2_Human1.58548154
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56015587
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55066349
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54066101
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51040542
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50108955
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50040037
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48940681
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45637599
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45531971
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43588703
65IGF1R_20145208_ChIP-Seq_DFB_Human1.42695478
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41575070
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.40846291
68TAF15_26573619_Chip-Seq_HEK293_Human1.39247427
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37755470
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36875229
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36350834
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.33070905
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32740040
74AR_21572438_ChIP-Seq_LNCaP_Human1.31659038
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.29922465
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.29378744
77* ELK1_22589737_ChIP-Seq_MCF10A_Human1.28910729
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.25789754
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24836999
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.24246431
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24211151
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.23343766
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.22674075
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.18186061
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16890924
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16634492
87EZH2_22144423_ChIP-Seq_EOC_Human1.16572098
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15384542
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15310662
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14134581
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13192330
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12537185
93P300_19829295_ChIP-Seq_ESCs_Human1.12416791
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10928876
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10580497
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09058516
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06483458
98AR_21909140_ChIP-Seq_LNCAP_Human1.05143989
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04613751
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04432754
101BCAT_22108803_ChIP-Seq_LS180_Human1.04267030
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03897315
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03497891
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03497891
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03361294
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03361294
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02670481
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01540896
109REST_21632747_ChIP-Seq_MESCs_Mouse1.01119455
110* HNF4A_19822575_ChIP-Seq_HepG2_Human1.00115857
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99197373
112TP53_22573176_ChIP-Seq_HFKS_Human0.98613143
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.98143419
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97624477
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97436182
116IRF1_19129219_ChIP-ChIP_H3396_Human0.97180201
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96819569
118KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96520682
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96398600
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93803407
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93648397
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93368498
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92867018
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92325963
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.92248588
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.91829130
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.91252449
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.90972702
129KDM5A_27292631_Chip-Seq_BREAST_Human0.89997295
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89745098
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89316483
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88863787
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.88520487
134RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88469447
135* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88323201
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88283559
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88203448
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87533893
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86797457
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86605346
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86551895
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86430999
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86082758
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84722341
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.84552542
146SMAD4_21799915_ChIP-Seq_A2780_Human0.84537159
147TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84233653
148AR_25329375_ChIP-Seq_VCAP_Human0.84187294
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83186645
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82060396
151EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81993535
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81414963
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81402272
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.80775851
155OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80223460
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79929927
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.78469433
158RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78048241
159* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77888382
160* FOXA1_25329375_ChIP-Seq_VCAP_Human0.77888382
161REST_18959480_ChIP-ChIP_MESCs_Mouse0.77659866
162SMAD1_18555785_Chip-Seq_ESCs_Mouse0.77293472
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.77130361
164NANOG_19829295_ChIP-Seq_ESCs_Human0.76981801
165SOX2_19829295_ChIP-Seq_ESCs_Human0.76981801
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76952596
167P53_22387025_ChIP-Seq_ESCs_Mouse0.76589161
168DROSHA_22980978_ChIP-Seq_HELA_Human0.76550950
169FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76435972
170MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75846686
171BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75100229
172P300_18555785_Chip-Seq_ESCs_Mouse0.74540012
173SMAD3_21741376_ChIP-Seq_EPCs_Human0.74223123
174CBX2_27304074_Chip-Seq_ESCs_Mouse0.73590270
175OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73435418
176E2F1_18555785_Chip-Seq_ESCs_Mouse0.73423211
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.73057478
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73042970
179OCT4_18555785_Chip-Seq_ESCs_Mouse0.72516414
180KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72267017
181CMYC_18555785_Chip-Seq_ESCs_Mouse0.72004977
182PU1_27457419_Chip-Seq_LIVER_Mouse0.71655603
183GATA1_22025678_ChIP-Seq_K562_Human0.71443814
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71306287
185SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69518573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.23590633
2MP0005360_urolithiasis6.59009935
3MP0005085_abnormal_gallbladder_physiolo5.45824728
4MP0005365_abnormal_bile_salt5.27882788
5MP0009379_abnormal_foot_pigmentation4.56100500
6MP0008875_abnormal_xenobiotic_pharmacok4.46853376
7MP0003806_abnormal_nucleotide_metabolis4.12829536
8MP0006292_abnormal_olfactory_placode3.84414325
9MP0008058_abnormal_DNA_repair3.24866103
10MP0003252_abnormal_bile_duct3.18654157
11MP0010329_abnormal_lipoprotein_level3.06783514
12MP0005332_abnormal_amino_acid3.00246961
13MP0009840_abnormal_foam_cell2.80117302
14MP0004957_abnormal_blastocyst_morpholog2.63035355
15MP0003693_abnormal_embryo_hatching2.61999305
16MP0002938_white_spotting2.61543345
17MP0010094_abnormal_chromosome_stability2.56173790
18MP0005083_abnormal_biliary_tract2.54803382
19MP0003195_calcinosis2.52242088
20MP0002102_abnormal_ear_morphology2.35202474
21MP0001666_abnormal_nutrient_absorption2.26841934
22MP0003718_maternal_effect2.24186308
23MP0001293_anophthalmia2.20179671
24MP0004019_abnormal_vitamin_homeostasis2.09746661
25MP0003690_abnormal_glial_cell2.08972535
26MP0003077_abnormal_cell_cycle2.05120813
27MP0006072_abnormal_retinal_apoptosis2.03193690
28MP0002118_abnormal_lipid_homeostasis1.92271919
29MP0003111_abnormal_nucleus_morphology1.89227344
30MP0008932_abnormal_embryonic_tissue1.87142375
31MP0000372_irregular_coat_pigmentation1.86614361
32MP0008877_abnormal_DNA_methylation1.86306408
33MP0008789_abnormal_olfactory_epithelium1.85340310
34MP0003011_delayed_dark_adaptation1.82059484
35MP0009697_abnormal_copulation1.80159052
36MP0003868_abnormal_feces_composition1.77462124
37MP0008995_early_reproductive_senescence1.63217149
38MP0002837_dystrophic_cardiac_calcinosis1.61977355
39MP0005584_abnormal_enzyme/coenzyme_acti1.58153370
40MP0003329_amyloid_beta_deposits1.55745094
41MP0000609_abnormal_liver_physiology1.55152025
42MP0002638_abnormal_pupillary_reflex1.52236213
43MP0008007_abnormal_cellular_replicative1.51115767
44MP0005646_abnormal_pituitary_gland1.49944447
45MP0003890_abnormal_embryonic-extraembry1.49080152
46MP0002822_catalepsy1.49020629
47MP0001764_abnormal_homeostasis1.48638339
48MP0003567_abnormal_fetal_cardiomyocyte1.45822157
49MP0003786_premature_aging1.44932997
50MP0000631_abnormal_neuroendocrine_gland1.44102646
51MP0002138_abnormal_hepatobiliary_system1.41649585
52MP0002277_abnormal_respiratory_mucosa1.41000071
53MP0002653_abnormal_ependyma_morphology1.38776297
54MP0005319_abnormal_enzyme/_coenzyme1.38235170
55MP0003186_abnormal_redox_activity1.37930443
56MP0004133_heterotaxia1.35849238
57MP0002234_abnormal_pharynx_morphology1.32994153
58MP0000604_amyloidosis1.30649553
59MP0004147_increased_porphyrin_level1.27660552
60MP0001286_abnormal_eye_development1.26888292
61MP0005647_abnormal_sex_gland1.26416869
62MP0005394_taste/olfaction_phenotype1.22801592
63MP0005499_abnormal_olfactory_system1.22801592
64MP0003191_abnormal_cellular_cholesterol1.21641993
65MP0000049_abnormal_middle_ear1.21506213
66MP0010030_abnormal_orbit_morphology1.20890729
67MP0003121_genomic_imprinting1.20869619
68MP0004885_abnormal_endolymph1.19117560
69MP0003937_abnormal_limbs/digits/tail_de1.18859448
70MP0002210_abnormal_sex_determination1.17821493
71MP0005253_abnormal_eye_physiology1.17750758
72MP0002876_abnormal_thyroid_physiology1.14949888
73MP0003656_abnormal_erythrocyte_physiolo1.14809791
74MP0008057_abnormal_DNA_replication1.14573355
75MP0001968_abnormal_touch/_nociception1.12267888
76MP0002254_reproductive_system_inflammat1.11832503
77MP0004043_abnormal_pH_regulation1.11142389
78MP0009643_abnormal_urine_homeostasis1.10717419
79MP0002751_abnormal_autonomic_nervous1.09499723
80MP0001188_hyperpigmentation1.08709542
81MP0002095_abnormal_skin_pigmentation1.07987595
82MP0005423_abnormal_somatic_nervous1.06710840
83MP0001486_abnormal_startle_reflex1.05951261
84MP0002233_abnormal_nose_morphology1.05944299
85MP0003941_abnormal_skin_development1.05414081
86MP0002160_abnormal_reproductive_system1.02921721
87MP0001929_abnormal_gametogenesis1.01475095
88MP0005451_abnormal_body_composition1.00270721
89MP0009764_decreased_sensitivity_to0.99834955
90MP0005636_abnormal_mineral_homeostasis0.98607543
91MP0009745_abnormal_behavioral_response0.97792892
92MP0004142_abnormal_muscle_tone0.95843934
93MP0003136_yellow_coat_color0.94861337
94MP0000647_abnormal_sebaceous_gland0.94171247
95MP0000653_abnormal_sex_gland0.94069201
96MP0000920_abnormal_myelination0.94048953
97MP0001145_abnormal_male_reproductive0.93590875
98MP0005535_abnormal_body_temperature0.92889089
99MP0003938_abnormal_ear_development0.90765633
100MP0002064_seizures0.90440361
101MP0003119_abnormal_digestive_system0.90131312
102MP0005195_abnormal_posterior_eye0.89820961
103MP0003315_abnormal_perineum_morphology0.89141228
104MP0003633_abnormal_nervous_system0.88688035
105MP0005389_reproductive_system_phenotype0.88360953
106MP0004215_abnormal_myocardial_fiber0.88155707
107MP0002163_abnormal_gland_morphology0.87490183
108MP0001661_extended_life_span0.86503693
109MP0005391_vision/eye_phenotype0.85939860
110MP0005551_abnormal_eye_electrophysiolog0.85415966
111MP0008872_abnormal_physiological_respon0.84812425
112MP0001502_abnormal_circadian_rhythm0.83992699
113MP0002697_abnormal_eye_size0.81618083
114MP0009046_muscle_twitch0.81447184
115MP0000566_synostosis0.81193652
116MP0001440_abnormal_grooming_behavior0.79301384
117MP0000358_abnormal_cell_content/0.79270426
118MP0003698_abnormal_male_reproductive0.77933083
119MP0005084_abnormal_gallbladder_morpholo0.77879083
120MP0005075_abnormal_melanosome_morpholog0.77828783
121MP0001919_abnormal_reproductive_system0.77467037
122MP0001905_abnormal_dopamine_level0.76914200
123MP0002282_abnormal_trachea_morphology0.76678184
124MP0009384_cardiac_valve_regurgitation0.76618166
125MP0005174_abnormal_tail_pigmentation0.76533087
126MP0003631_nervous_system_phenotype0.75655019
127MP0006036_abnormal_mitochondrial_physio0.74958500
128MP0003635_abnormal_synaptic_transmissio0.74918205
129MP0004145_abnormal_muscle_electrophysio0.74386322
130MP0001697_abnormal_embryo_size0.74310173
131MP0003755_abnormal_palate_morphology0.74032045
132MP0002752_abnormal_somatic_nervous0.73904320
133MP0002272_abnormal_nervous_system0.73761969
134MP0003122_maternal_imprinting0.73016270
135MP0003075_altered_response_to0.72819194
136MP0005187_abnormal_penis_morphology0.72444365
137MP0001324_abnormal_eye_pigmentation0.71692826
138MP0002572_abnormal_emotion/affect_behav0.71677072
139MP0004270_analgesia0.71132282
140MP0001984_abnormal_olfaction0.70794049
141MP0005408_hypopigmentation0.70635791
142MP0005376_homeostasis/metabolism_phenot0.69486315
143MP0009642_abnormal_blood_homeostasis0.68498363
144MP0002063_abnormal_learning/memory/cond0.67769145
145MP0003632_abnormal_nervous_system0.66915804
146MP0004859_abnormal_synaptic_plasticity0.65639404
147MP0004381_abnormal_hair_follicle0.65237514
148MP0005645_abnormal_hypothalamus_physiol0.65186484
149MP0002078_abnormal_glucose_homeostasis0.64184371
150MP0009763_increased_sensitivity_to0.63881627
151MP0002229_neurodegeneration0.63212070
152MP0001485_abnormal_pinna_reflex0.62959215
153MP0000639_abnormal_adrenal_gland0.62664449
154MP0008874_decreased_physiological_sensi0.62088769
155MP0001501_abnormal_sleep_pattern0.62005295
156MP0000598_abnormal_liver_morphology0.61525039
157MP0009765_abnormal_xenobiotic_induced0.61236571
158MP0003638_abnormal_response/metabolism_0.60514397
159MP0002971_abnormal_brown_adipose0.58924540
160MP0002090_abnormal_vision0.58817750
161MP0006276_abnormal_autonomic_nervous0.58733034
162MP0003634_abnormal_glial_cell0.58365742
163MP0006035_abnormal_mitochondrial_morpho0.58327629
164MP0000579_abnormal_nail_morphology0.56711565
165MP0003880_abnormal_central_pattern0.56007236
166MP0005670_abnormal_white_adipose0.55177391
167MP0001529_abnormal_vocalization0.53277569
168MP0002067_abnormal_sensory_capabilities0.51993449
169MP0005595_abnormal_vascular_smooth0.51683226
170MP0005266_abnormal_metabolism0.50828491
171MP0008469_abnormal_protein_level0.48987700
172MP0002736_abnormal_nociception_after0.48896715
173MP0003953_abnormal_hormone_level0.48051246

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.69710326
2Intrahepatic cholestasis (HP:0001406)6.41236857
3Deep venous thrombosis (HP:0002625)5.63782598
4Prolonged partial thromboplastin time (HP:0003645)5.62575441
5Xanthomatosis (HP:0000991)5.37561944
6Acute necrotizing encephalopathy (HP:0006965)5.34228105
7Hyperlipoproteinemia (HP:0010980)5.32472113
8Hypobetalipoproteinemia (HP:0003563)5.28048104
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.24354893
10Abnormal mitochondria in muscle tissue (HP:0008316)4.87221218
11Increased hepatocellular lipid droplets (HP:0006565)4.76925752
12Mitochondrial inheritance (HP:0001427)4.73228770
13Hyperglycinemia (HP:0002154)4.68308026
14Abnormality of glycine metabolism (HP:0010895)4.44623467
15Abnormality of serine family amino acid metabolism (HP:0010894)4.44623467
16Progressive macrocephaly (HP:0004481)4.40220966
17Lipid accumulation in hepatocytes (HP:0006561)4.37947238
18Hyperglycinuria (HP:0003108)4.35261351
19Increased CSF lactate (HP:0002490)4.33361730
20Hyperammonemia (HP:0001987)4.31434538
21Abnormality of cells of the erythroid lineage (HP:0012130)4.22760494
22Abnormality of methionine metabolism (HP:0010901)4.17967764
23Hypolipoproteinemia (HP:0010981)4.08188801
24Complement deficiency (HP:0004431)4.06587525
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04022958
26Abnormal number of erythroid precursors (HP:0012131)3.97864320
27Reticulocytopenia (HP:0001896)3.95232347
28Ketosis (HP:0001946)3.92299595
29Hepatocellular necrosis (HP:0001404)3.89285948
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.86830697
31Renal Fanconi syndrome (HP:0001994)3.80488680
32Joint hemorrhage (HP:0005261)3.77759341
33Macrocytic anemia (HP:0001972)3.76747204
34Epidermoid cyst (HP:0200040)3.75042091
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70024703
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68937201
37Fat malabsorption (HP:0002630)3.66603606
38Hypoalphalipoproteinemia (HP:0003233)3.66344956
39Conjugated hyperbilirubinemia (HP:0002908)3.63766477
40Hepatic necrosis (HP:0002605)3.58405277
41Delayed CNS myelination (HP:0002188)3.36162151
42Hypoglycemic coma (HP:0001325)3.28283371
43Abnormality of the common coagulation pathway (HP:0010990)3.21322310
44Increased intramyocellular lipid droplets (HP:0012240)3.16853065
453-Methylglutaconic aciduria (HP:0003535)3.14365912
46Colon cancer (HP:0003003)3.11994582
47Abnormality of serum amino acid levels (HP:0003112)3.10435164
48Confusion (HP:0001289)3.06801177
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05787250
50Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05787250
51Ketoacidosis (HP:0001993)3.03695049
52Congenital, generalized hypertrichosis (HP:0004540)3.03144063
53Exertional dyspnea (HP:0002875)2.96700329
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.91753153
55Steatorrhea (HP:0002570)2.90587513
56Abnormality of fatty-acid metabolism (HP:0004359)2.88186103
57Hyperbilirubinemia (HP:0002904)2.87856314
58Increased serum lactate (HP:0002151)2.83717125
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.80965766
60Lethargy (HP:0001254)2.77859282
61Hypercholesterolemia (HP:0003124)2.74721170
62Abnormality of pyrimidine metabolism (HP:0004353)2.74029269
63Pallor (HP:0000980)2.73730851
64Pancreatic cysts (HP:0001737)2.73486176
65Lactic acidosis (HP:0003128)2.71792385
66Optic disc pallor (HP:0000543)2.69352126
67Molar tooth sign on MRI (HP:0002419)2.65906097
68Abnormality of midbrain morphology (HP:0002418)2.65906097
69Metabolic acidosis (HP:0001942)2.65809072
70Abnormality of complement system (HP:0005339)2.64483057
71Abnormality of the intrinsic pathway (HP:0010989)2.61941904
72Neurofibrillary tangles (HP:0002185)2.61273093
73Respiratory difficulties (HP:0002880)2.60288223
74Dicarboxylic aciduria (HP:0003215)2.60089903
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60089903
76Pancreatic fibrosis (HP:0100732)2.59460235
77Increased muscle lipid content (HP:0009058)2.57181093
78Leukodystrophy (HP:0002415)2.57103087
79Hypoglycemic seizures (HP:0002173)2.56486385
80Cerebral edema (HP:0002181)2.54758327
81Respiratory failure (HP:0002878)2.53417971
82Septo-optic dysplasia (HP:0100842)2.52085495
83Enlarged kidneys (HP:0000105)2.51614992
84Abnormality of renal resorption (HP:0011038)2.51257992
85Exercise intolerance (HP:0003546)2.48361713
86Status epilepticus (HP:0002133)2.46571391
87Gout (HP:0001997)2.45198979
88Abnormality of nucleobase metabolism (HP:0010932)2.44093139
89Sensorimotor neuropathy (HP:0007141)2.43670910
90True hermaphroditism (HP:0010459)2.43106134
91Vascular calcification (HP:0004934)2.42227003
92Abnormality of the labia minora (HP:0012880)2.38629871
93Spastic paraparesis (HP:0002313)2.32483954
94Meckel diverticulum (HP:0002245)2.31960824
95Alkalosis (HP:0001948)2.31661876
96Abnormality of purine metabolism (HP:0004352)2.29125075
97Amyloidosis (HP:0011034)2.27866430
98Hyperventilation (HP:0002883)2.26301182
99Aplastic anemia (HP:0001915)2.25203410
100Nephronophthisis (HP:0000090)2.24092656
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.23981423
102Irritability (HP:0000737)2.23870681
103Abnormality of the ileum (HP:0001549)2.21614468
104Methylmalonic acidemia (HP:0002912)2.20731134
105Hypochromic microcytic anemia (HP:0004840)2.20418170
106Absent thumb (HP:0009777)2.19460171
107Spontaneous abortion (HP:0005268)2.18738026
108Hypophosphatemic rickets (HP:0004912)2.17644711
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16648324
110Methylmalonic aciduria (HP:0012120)2.16252595
111Stenosis of the external auditory canal (HP:0000402)2.16017726
112Acanthocytosis (HP:0001927)2.13129838
113Increased serum pyruvate (HP:0003542)2.12537418
114Abnormality of vitamin metabolism (HP:0100508)2.12167856
115Vomiting (HP:0002013)2.11985866
116Hepatocellular carcinoma (HP:0001402)2.11374935
117Cholecystitis (HP:0001082)2.10291857
118Abnormal gallbladder physiology (HP:0012438)2.10291857
119Abnormal gallbladder morphology (HP:0012437)2.08405112
120Skin nodule (HP:0200036)2.07394063
121Paraparesis (HP:0002385)2.06794903
122Medial flaring of the eyebrow (HP:0010747)2.05291686
123Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04900771
124Rickets (HP:0002748)2.03688427
125Sclerocornea (HP:0000647)2.03389673
126Triphalangeal thumb (HP:0001199)2.03239635
127Cardiovascular calcification (HP:0011915)2.03182870
128Brushfield spots (HP:0001088)2.02173510
129Opisthotonus (HP:0002179)2.01413477
130Oral leukoplakia (HP:0002745)2.01058643
131Abnormality of chromosome stability (HP:0003220)1.97703220
132Abnormality of alanine metabolism (HP:0010916)1.96873073
133Hyperalaninemia (HP:0003348)1.96873073
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96873073
135Generalized aminoaciduria (HP:0002909)1.95622605
136Renal cortical cysts (HP:0000803)1.95528455
137Type I transferrin isoform profile (HP:0003642)1.95315138
138Absent septum pellucidum (HP:0001331)1.95255185
139Cholelithiasis (HP:0001081)1.93318635
140Hyperinsulinemic hypoglycemia (HP:0000825)1.93078946
141Acute encephalopathy (HP:0006846)1.91162809
142Myocardial infarction (HP:0001658)1.90919015
143Symptomatic seizures (HP:0011145)1.90872243
144Hyperphosphaturia (HP:0003109)1.90201347
145Abnormality of the preputium (HP:0100587)1.90131874
146Glycosuria (HP:0003076)1.88907826
147Abnormality of urine glucose concentration (HP:0011016)1.88907826
148Systemic lupus erythematosus (HP:0002725)1.88710616
149Tetraplegia (HP:0002445)1.88657282
150X-linked dominant inheritance (HP:0001423)1.86825593
151Neonatal onset (HP:0003623)1.86352628
152Cerebral inclusion bodies (HP:0100314)1.85273106
153Abnormality of the axillary hair (HP:0100134)1.84592281
154Abnormality of secondary sexual hair (HP:0009888)1.84592281
155Abnormal lung lobation (HP:0002101)1.82828173
156CNS demyelination (HP:0007305)1.81800433
157Abnormal biliary tract physiology (HP:0012439)1.80612632
158Bile duct proliferation (HP:0001408)1.80612632
159Pancytopenia (HP:0001876)1.80284378
160Birth length less than 3rd percentile (HP:0003561)1.79674857
161Delayed myelination (HP:0012448)1.79123267
162Abnormality of proline metabolism (HP:0010907)1.78392392
163Hydroxyprolinuria (HP:0003080)1.78392392
164Rib fusion (HP:0000902)1.77957612
165Proximal tubulopathy (HP:0000114)1.77385553
166Pancreatitis (HP:0001733)1.74541029
167Abnormality of the gallbladder (HP:0005264)1.74114460
168Abnormality of the renal medulla (HP:0100957)1.72400614
169Abnormality of glycolysis (HP:0004366)1.72247603
170Pendular nystagmus (HP:0012043)1.71976911
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67651494
172Small intestinal stenosis (HP:0012848)1.66236156
173Duodenal stenosis (HP:0100867)1.66236156
174Abnormality of the anterior horn cell (HP:0006802)1.65777670
175Degeneration of anterior horn cells (HP:0002398)1.65777670
176Optic nerve hypoplasia (HP:0000609)1.65472230
177Abnormality of placental membranes (HP:0011409)1.63859032
178Amniotic constriction ring (HP:0009775)1.63859032
179Male pseudohermaphroditism (HP:0000037)1.63489175
180Abnormality of the septum pellucidum (HP:0007375)1.63103117
181Depressed nasal ridge (HP:0000457)1.62885422
182Megaloblastic anemia (HP:0001889)1.62593080
183Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61625128
184Congenital primary aphakia (HP:0007707)1.61369399
185Hypoplasia of the pons (HP:0012110)1.59655517
186Chromsome breakage (HP:0040012)1.59642907
187Abnormal glycosylation (HP:0012345)1.58924869
188Abnormal protein N-linked glycosylation (HP:0012347)1.58924869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.59794040
2VRK24.16311508
3BUB13.55873276
4EPHA43.49167798
5CDC73.03193227
6TNIK2.96949055
7SIK12.92959880
8ZAK2.80770115
9INSRR2.61172784
10ERBB42.45580561
11VRK12.43488645
12SRPK12.38735719
13CASK2.35637059
14NUAK12.25086004
15NEK12.20108855
16SGK2232.14784485
17SGK4942.14784485
18NME12.14014283
19OXSR12.08804724
20TRIM282.06050475
21PLK42.03887545
22MAP2K42.00881015
23PBK1.98419671
24PINK11.89926633
25PLK31.86196147
26TTK1.77523441
27SGK21.77420223
28NTRK21.76264366
29STK391.74743374
30MUSK1.73728570
31MKNK11.73697636
32FGFR41.72909653
33WEE11.71454606
34EIF2AK31.64994931
35DYRK21.64030055
36MAP2K71.62365972
37EIF2AK11.58635748
38MKNK21.57540775
39DAPK21.57271797
40TAF11.56221623
41PKN11.49823575
42IRAK31.48320179
43BRSK21.47939996
44CAMK2G1.43820338
45NTRK31.43718210
46TLK11.43125385
47MAP4K21.41003237
48FGFR21.39752772
49TAOK31.36688067
50SGK31.34731122
51PLK11.33515263
52IRAK21.32135638
53MST1R1.31155231
54PHKG11.27489536
55PHKG21.27489536
56PRKCG1.26634378
57STK161.19366237
58PRPF4B1.17737754
59WNK41.17526945
60MAP3K41.16289476
61MAPK121.13930686
62LMTK21.11703843
63MAPK111.10913730
64WNK31.08615885
65PIK3CG1.07274702
66DYRK31.05862342
67MAP3K121.05319394
68CAMK2B1.00282459
69PASK0.99899976
70TSSK60.99656136
71ABL20.99251748
72AURKB0.98104188
73CAMK2A0.97890204
74MARK10.96188627
75NME20.95472009
76BMPR1B0.94806245
77CCNB10.94291182
78MAPKAPK50.93450720
79PRKCZ0.91642005
80PRKCQ0.89649782
81PNCK0.89464497
82CHEK20.88852621
83MAPK150.87719124
84CSNK1G10.86425253
85ATR0.85045407
86ERBB30.84470833
87MAPK40.83548772
88NEK60.81976322
89NEK20.80284719
90PRKAA20.80063546
91PRKACG0.79913937
92PDK20.79439183
93GRK10.79089824
94PRKCE0.77753968
95MAPK70.77380097
96ADRBK20.77167275
97ACVR1B0.74928323
98CSNK1G20.74741368
99MAP3K70.73265208
100EIF2AK20.72187721
101GRK60.70464217
102PLK20.70235049
103AURKA0.69780768
104MINK10.69470137
105CSNK2A20.68341580
106MET0.67693294
107MAPK130.67441598
108CDK80.67413422
109CDK190.66147197
110PRKACA0.64485841
111CSNK2A10.64460481
112PRKCA0.64390626
113DYRK1A0.61959286
114BRSK10.61151420
115EPHB10.60506643
116ERBB20.60155743
117PRKG10.59931278
118CSNK1G30.59860250
119CAMK2D0.58334271
120IRAK10.57923130
121PDPK10.56719048
122NTRK10.56360286
123TGFBR10.56106690
124SGK10.54543997
125PAK30.54423945
126TNK20.54051137
127CSNK1A1L0.53802221
128GRK50.53665653
129CDK50.53151439
130RPS6KA40.52082939
131RPS6KA50.51468111
132EPHB20.51244938
133GRK70.50411344
134MAP2K60.50365086
135STK40.50148723
136ARAF0.48618840
137ATM0.48548160
138BCR0.48354601
139STK30.48112555
140IGF1R0.47927000
141OBSCN0.46922656
142MAP3K130.45102209
143ADRBK10.44653223
144PIK3CA0.44244907
145CSNK1E0.43961558
146GSK3A0.43052076
147PRKACB0.42702197
148CSNK1A10.41810936
149FRK0.41305923
150TEC0.40607891
151RPS6KA30.40330104
152FGR0.39654365
153CHEK10.37718398
154PRKCH0.37683498
155ERN10.37371158
156MST40.36404025
157STK38L0.36145395
158CDK30.31633829
159DAPK30.31456364
160TIE10.30424286
161CDK10.28837144
162RPS6KB20.26337340

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.94947552
2Nitrogen metabolism_Homo sapiens_hsa009104.69748247
3Proteasome_Homo sapiens_hsa030504.06732330
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.97225439
5Protein export_Homo sapiens_hsa030603.20011307
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.97394988
7Mismatch repair_Homo sapiens_hsa034302.86557860
8RNA polymerase_Homo sapiens_hsa030202.79526803
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77661834
10Arginine biosynthesis_Homo sapiens_hsa002202.74934548
11Huntingtons disease_Homo sapiens_hsa050162.74777443
12Homologous recombination_Homo sapiens_hsa034402.59114979
13DNA replication_Homo sapiens_hsa030302.56336141
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50489588
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47754026
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46074916
17Fatty acid degradation_Homo sapiens_hsa000712.44274104
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38628788
19Tryptophan metabolism_Homo sapiens_hsa003802.36537017
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31326057
21Butanoate metabolism_Homo sapiens_hsa006502.29563820
22Complement and coagulation cascades_Homo sapiens_hsa046102.18409029
23Peroxisome_Homo sapiens_hsa041462.15400034
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08906440
25Spliceosome_Homo sapiens_hsa030402.07949556
26Propanoate metabolism_Homo sapiens_hsa006401.99682254
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98427025
28Histidine metabolism_Homo sapiens_hsa003401.98403512
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95226045
30Fatty acid metabolism_Homo sapiens_hsa012121.94885848
31Nucleotide excision repair_Homo sapiens_hsa034201.94847281
32Cardiac muscle contraction_Homo sapiens_hsa042601.93870860
33Fanconi anemia pathway_Homo sapiens_hsa034601.83337706
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.82589754
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80390002
36Basal transcription factors_Homo sapiens_hsa030221.80081775
37Chemical carcinogenesis_Homo sapiens_hsa052041.80081567
38PPAR signaling pathway_Homo sapiens_hsa033201.79252117
39Steroid biosynthesis_Homo sapiens_hsa001001.79212038
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.78885475
41Fatty acid elongation_Homo sapiens_hsa000621.74581131
42RNA degradation_Homo sapiens_hsa030181.73837133
43beta-Alanine metabolism_Homo sapiens_hsa004101.68012872
44RNA transport_Homo sapiens_hsa030131.63860307
45Base excision repair_Homo sapiens_hsa034101.62567040
46Retinol metabolism_Homo sapiens_hsa008301.61717077
47Bile secretion_Homo sapiens_hsa049761.61119140
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60223133
49Pyrimidine metabolism_Homo sapiens_hsa002401.55935551
50Sulfur metabolism_Homo sapiens_hsa009201.55188688
51Non-homologous end-joining_Homo sapiens_hsa034501.53416472
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48634831
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48250461
54Vitamin B6 metabolism_Homo sapiens_hsa007501.48080696
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44872270
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.35487534
57Caffeine metabolism_Homo sapiens_hsa002321.34260301
58Tyrosine metabolism_Homo sapiens_hsa003501.32857663
59Phenylalanine metabolism_Homo sapiens_hsa003601.29440589
60Pyruvate metabolism_Homo sapiens_hsa006201.26046372
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21681325
62Arginine and proline metabolism_Homo sapiens_hsa003301.20378413
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.19522312
64Fatty acid biosynthesis_Homo sapiens_hsa000611.18167982
65Purine metabolism_Homo sapiens_hsa002301.16963557
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16782477
67Staphylococcus aureus infection_Homo sapiens_hsa051501.15235327
68Selenocompound metabolism_Homo sapiens_hsa004501.14367068
69Folate biosynthesis_Homo sapiens_hsa007901.12483161
70Starch and sucrose metabolism_Homo sapiens_hsa005001.10283035
71Vitamin digestion and absorption_Homo sapiens_hsa049771.09802026
72ABC transporters_Homo sapiens_hsa020101.05970773
73Cell cycle_Homo sapiens_hsa041101.03920781
74Biosynthesis of amino acids_Homo sapiens_hsa012301.00438927
75Carbon metabolism_Homo sapiens_hsa012000.88515320
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.88003170
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86846808
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.86266737
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84360156
80Fat digestion and absorption_Homo sapiens_hsa049750.80339859
81Phototransduction_Homo sapiens_hsa047440.79688011
82Glycerolipid metabolism_Homo sapiens_hsa005610.79027791
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78803737
84Sulfur relay system_Homo sapiens_hsa041220.72988638
85Glutathione metabolism_Homo sapiens_hsa004800.70780554
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69709816
87Collecting duct acid secretion_Homo sapiens_hsa049660.58846755
88Metabolic pathways_Homo sapiens_hsa011000.57896456
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56517912
90mRNA surveillance pathway_Homo sapiens_hsa030150.56136761
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50916118
92Oocyte meiosis_Homo sapiens_hsa041140.49276256
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49095863
94Lysine degradation_Homo sapiens_hsa003100.47021937
95p53 signaling pathway_Homo sapiens_hsa041150.45345611
96Pentose phosphate pathway_Homo sapiens_hsa000300.45197615
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40215124
98Nicotine addiction_Homo sapiens_hsa050330.39048815
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.38583949
100GABAergic synapse_Homo sapiens_hsa047270.37136751
101Basal cell carcinoma_Homo sapiens_hsa052170.36090975
102Fructose and mannose metabolism_Homo sapiens_hsa000510.32467275
103Systemic lupus erythematosus_Homo sapiens_hsa053220.31677313
104One carbon pool by folate_Homo sapiens_hsa006700.31440419
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29687707
106Linoleic acid metabolism_Homo sapiens_hsa005910.29599392
107Hedgehog signaling pathway_Homo sapiens_hsa043400.29047908
108Prion diseases_Homo sapiens_hsa050200.26975261
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26840090
110Olfactory transduction_Homo sapiens_hsa047400.26430249
111Ether lipid metabolism_Homo sapiens_hsa005650.23463211
112Oxidative phosphorylation_Homo sapiens_hsa001900.21614322
113Epstein-Barr virus infection_Homo sapiens_hsa051690.20739149
114Glutamatergic synapse_Homo sapiens_hsa047240.15561780
115Alcoholism_Homo sapiens_hsa050340.15457836
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14037698
117N-Glycan biosynthesis_Homo sapiens_hsa005100.13111406
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12970928
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11989942
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10764805
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.08980030
122Galactose metabolism_Homo sapiens_hsa000520.08544953
123Mineral absorption_Homo sapiens_hsa049780.08455528
124Arachidonic acid metabolism_Homo sapiens_hsa005900.05482899
125Regulation of autophagy_Homo sapiens_hsa041400.03288753
126Alzheimers disease_Homo sapiens_hsa050100.03165127
127Cocaine addiction_Homo sapiens_hsa050300.02840009
128Parkinsons disease_Homo sapiens_hsa050120.02532184
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.00802425
130Taste transduction_Homo sapiens_hsa04742-0.0572809
131African trypanosomiasis_Homo sapiens_hsa05143-0.0572294
132Morphine addiction_Homo sapiens_hsa05032-0.0517631
133Salivary secretion_Homo sapiens_hsa04970-0.0514183
134Insulin secretion_Homo sapiens_hsa04911-0.0286652
135Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0255542
136Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0231661
137Glucagon signaling pathway_Homo sapiens_hsa04922-0.0227677
138Circadian rhythm_Homo sapiens_hsa04710-0.0107840

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