TPRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)6.57894073
2establishment of skin barrier (GO:0061436)5.29515527
3regulation of female gonad development (GO:2000194)4.31711847
4regulation of water loss via skin (GO:0033561)4.26858240
5positive regulation of humoral immune response (GO:0002922)4.14300994
6regulation of meiosis I (GO:0060631)4.07940802
7piRNA metabolic process (GO:0034587)4.03394499
8pyrimidine-containing compound transmembrane transport (GO:0072531)4.02573294
9keratinocyte differentiation (GO:0030216)4.00999794
10multicellular organism reproduction (GO:0032504)3.78835330
11regulation of sequestering of triglyceride (GO:0010889)3.77413015
12positive regulation of uterine smooth muscle contraction (GO:0070474)3.57814513
13exogenous drug catabolic process (GO:0042738)3.41533814
14oocyte development (GO:0048599)3.35563230
15regulation of gamma-delta T cell activation (GO:0046643)3.32974724
16regulation of acrosome reaction (GO:0060046)3.32271498
17regulation of gamma-delta T cell differentiation (GO:0045586)3.31038339
18peptide cross-linking (GO:0018149)3.25293219
19T-helper cell differentiation (GO:0042093)3.21365095
20CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21365095
21DNA deamination (GO:0045006)3.19242597
22negative T cell selection (GO:0043383)3.11276573
23regulation of DNA methylation (GO:0044030)3.10782522
24cytidine deamination (GO:0009972)3.09774489
25cytidine metabolic process (GO:0046087)3.09774489
26cytidine catabolic process (GO:0006216)3.09774489
27regulation of hypersensitivity (GO:0002883)3.04341408
28hair cycle (GO:0042633)3.04228189
29molting cycle (GO:0042303)3.04228189
30negative regulation of mast cell activation (GO:0033004)3.02821128
31regulation of B cell receptor signaling pathway (GO:0050855)3.01137351
32drug catabolic process (GO:0042737)3.00415920
33xenobiotic catabolic process (GO:0042178)2.99128152
34positive regulation of gamma-delta T cell activation (GO:0046645)2.97486707
35meiotic cell cycle (GO:0051321)2.94829713
36regulation of uterine smooth muscle contraction (GO:0070472)2.93799073
37DNA methylation involved in gamete generation (GO:0043046)2.91932436
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89230042
39female gamete generation (GO:0007292)2.82351654
40cellular response to interleukin-15 (GO:0071350)2.80376819
41keratinocyte proliferation (GO:0043616)2.79723960
42indole-containing compound catabolic process (GO:0042436)2.79257537
43indolalkylamine catabolic process (GO:0046218)2.79257537
44tryptophan catabolic process (GO:0006569)2.79257537
45regulation of steroid hormone secretion (GO:2000831)2.75177696
46epidermal cell differentiation (GO:0009913)2.75118664
47negative regulation of execution phase of apoptosis (GO:1900118)2.73134303
48alpha-beta T cell differentiation involved in immune response (GO:0002293)2.72197485
49alpha-beta T cell activation involved in immune response (GO:0002287)2.72197485
50T cell differentiation involved in immune response (GO:0002292)2.72197485
51low-density lipoprotein particle clearance (GO:0034383)2.71395240
52tyrosine phosphorylation of STAT protein (GO:0007260)2.69855475
53cellular response to arsenic-containing substance (GO:0071243)2.69320097
54signal peptide processing (GO:0006465)2.65798334
55multicellular organismal water homeostasis (GO:0050891)2.65123581
56protein K11-linked deubiquitination (GO:0035871)2.62770772
57water homeostasis (GO:0030104)2.61820161
58pyrimidine ribonucleoside catabolic process (GO:0046133)2.61039730
59negative regulation of T cell mediated immunity (GO:0002710)2.60178829
60regulation of regulatory T cell differentiation (GO:0045589)2.59584577
61interleukin-6-mediated signaling pathway (GO:0070102)2.57463991
62regulation of macrophage chemotaxis (GO:0010758)2.57235745
63intestinal epithelial cell development (GO:0060576)2.57103425
64tryptophan metabolic process (GO:0006568)2.56526979
65positive regulation of interleukin-4 production (GO:0032753)2.56184158
66membrane raft organization (GO:0031579)2.54821303
67regulation of triglyceride catabolic process (GO:0010896)2.53771514
68negative thymic T cell selection (GO:0045060)2.52345534
69response to interleukin-15 (GO:0070672)2.50996131
70retinal cone cell development (GO:0046549)2.50763472
71reproduction (GO:0000003)2.40851862
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.37795403
73sphingoid metabolic process (GO:0046519)2.37597978
74regulation of cell maturation (GO:1903429)2.37517827
75lipoxygenase pathway (GO:0019372)2.35492896
76regulation of interleukin-2 biosynthetic process (GO:0045076)2.35220288
77gene silencing by RNA (GO:0031047)2.33448413
78genitalia morphogenesis (GO:0035112)2.33069082
79negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.32570600
80detection of bacterium (GO:0016045)2.31057532
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.28875462
82indolalkylamine metabolic process (GO:0006586)2.28465701
83regulation of phospholipase A2 activity (GO:0032429)2.27705080
84keratinocyte development (GO:0003334)2.27335819
85detection of other organism (GO:0098543)2.25562464
86positive regulation of defense response to virus by host (GO:0002230)2.24609740
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.24516036
88regulation of T cell tolerance induction (GO:0002664)2.24047613
89negative regulation of protein autophosphorylation (GO:0031953)2.23797336
90CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.23787091
91regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.23314560
92cellular response to ethanol (GO:0071361)2.22186082
93response to type I interferon (GO:0034340)2.21938362
94lung lobe morphogenesis (GO:0060463)2.21570565
95polyol transport (GO:0015791)2.21451801
96cellular response to type I interferon (GO:0071357)2.20892986
97type I interferon signaling pathway (GO:0060337)2.20892986
98positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.20480539
99lymphocyte costimulation (GO:0031294)2.19706220
100detection of light stimulus involved in sensory perception (GO:0050962)2.19546900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38410323
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.01857341
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74997648
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.71325985
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14595637
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.07782930
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90721383
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.85772208
9VDR_22108803_ChIP-Seq_LS180_Human2.66973521
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50079589
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.21132693
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.17107448
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16335071
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15809562
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.98292134
16* RUNX_20019798_ChIP-Seq_JUKART_Human1.82934715
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82214297
18GBX2_23144817_ChIP-Seq_PC3_Human1.78147880
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69383471
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66601641
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.64143638
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64096884
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61142205
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55355751
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.52577208
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51455606
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47548562
28ER_23166858_ChIP-Seq_MCF-7_Human1.44486894
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44411138
30BCAT_22108803_ChIP-Seq_LS180_Human1.42344776
31* AHR_22903824_ChIP-Seq_MCF-7_Human1.42129468
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39757286
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39183867
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.37840423
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36577552
36CBP_20019798_ChIP-Seq_JUKART_Human1.36577552
37TAF15_26573619_Chip-Seq_HEK293_Human1.35486703
38* PRDM14_20953172_ChIP-Seq_ESCs_Human1.33987136
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33740399
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32811442
41* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31459897
42CDX2_22108803_ChIP-Seq_LS180_Human1.30403931
43GATA3_26560356_Chip-Seq_TH2_Human1.29246952
44CJUN_26792858_Chip-Seq_BT549_Human1.29225345
45VDR_24787735_ChIP-Seq_THP-1_Human1.28413476
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.26945424
47TP63_23658742_ChIP-Seq_EP156T_Human1.26040296
48GATA1_22025678_ChIP-Seq_K562_Human1.24651527
49IGF1R_20145208_ChIP-Seq_DFB_Human1.23728906
50* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21489948
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19925705
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19534209
53MYB_26560356_Chip-Seq_TH2_Human1.18769548
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.18350107
55STAT3_23295773_ChIP-Seq_U87_Human1.17857573
56* ARNT_22903824_ChIP-Seq_MCF-7_Human1.15996182
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14759331
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.14580610
59* AR_25329375_ChIP-Seq_VCAP_Human1.14548658
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14464192
61SMAD4_21799915_ChIP-Seq_A2780_Human1.14430037
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14369120
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13665115
64TCF4_23295773_ChIP-Seq_U87_Human1.13527701
65TP53_16413492_ChIP-PET_HCT116_Human1.12641826
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12015392
67* SMRT_27268052_Chip-Seq_Bcells_Human1.11320371
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10427024
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.10408953
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08979019
71* P300_19829295_ChIP-Seq_ESCs_Human1.08934841
72NANOG_19829295_ChIP-Seq_ESCs_Human1.08350152
73SOX2_19829295_ChIP-Seq_ESCs_Human1.08350152
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08077149
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.06551023
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04779842
77* TCF4_22108803_ChIP-Seq_LS180_Human1.03413261
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02880720
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.02147387
80HTT_18923047_ChIP-ChIP_STHdh_Human1.02011184
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00791425
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00190792
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.00088300
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99678349
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99667172
86GATA3_27048872_Chip-Seq_THYMUS_Human0.99338105
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99108131
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.98044378
89TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97891386
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97183117
91LXR_22158963_ChIP-Seq_LIVER_Mouse0.97159300
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95199519
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94625066
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94625066
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94588429
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93119286
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93005529
98RXR_22108803_ChIP-Seq_LS180_Human0.92370419
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91901584
100FUS_26573619_Chip-Seq_HEK293_Human0.90402092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.84928373
2MP0002796_impaired_skin_barrier3.55952881
3MP0002138_abnormal_hepatobiliary_system3.54051804
4MP0003718_maternal_effect3.33457972
5MP0005275_abnormal_skin_tensile3.13467465
6MP0004381_abnormal_hair_follicle3.09367547
7MP0003950_abnormal_plasma_membrane3.02613963
8MP0002139_abnormal_hepatobiliary_system2.71986015
9MP0005671_abnormal_response_to2.70021914
10MP0003646_muscle_fatigue2.44544578
11MP0003045_fibrosis2.17889341
12MP0010678_abnormal_skin_adnexa2.01883328
13MP0000427_abnormal_hair_cycle1.84821945
14MP0006082_CNS_inflammation1.82065223
15MP0005387_immune_system_phenotype1.77662969
16MP0001790_abnormal_immune_system1.77662969
17MP0001853_heart_inflammation1.76016473
18MP0000685_abnormal_immune_system1.76007220
19MP0003763_abnormal_thymus_physiology1.71770578
20MP0003195_calcinosis1.69489379
21MP0002166_altered_tumor_susceptibility1.67339320
22MP0002148_abnormal_hypersensitivity_rea1.65860511
23MP0001835_abnormal_antigen_presentation1.64590996
24MP0005395_other_phenotype1.64330155
25MP0005647_abnormal_sex_gland1.64283474
26MP0005670_abnormal_white_adipose1.63566939
27MP0004947_skin_inflammation1.61078928
28MP0000383_abnormal_hair_follicle1.60342907
29MP0009785_altered_susceptibility_to1.54768034
30MP0001800_abnormal_humoral_immune1.52420286
31MP0005501_abnormal_skin_physiology1.51324598
32MP0009840_abnormal_foam_cell1.50419216
33MP0003252_abnormal_bile_duct1.50055074
34MP0003453_abnormal_keratinocyte_physiol1.41916328
35MP0008789_abnormal_olfactory_epithelium1.39428194
36MP0001216_abnormal_epidermal_layer1.38252303
37MP0009115_abnormal_fat_cell1.37860539
38MP0002452_abnormal_antigen_presenting1.34863252
39MP0001873_stomach_inflammation1.34069609
40MP0003191_abnormal_cellular_cholesterol1.32483107
41MP0002006_tumorigenesis1.32411729
42MP0008057_abnormal_DNA_replication1.31196598
43MP0005000_abnormal_immune_tolerance1.30787558
44MP0003724_increased_susceptibility_to1.30267767
45MP0002876_abnormal_thyroid_physiology1.28512180
46MP0004130_abnormal_muscle_cell1.28256146
47MP0002723_abnormal_immune_serum1.26107501
48MP0005167_abnormal_blood-brain_barrier1.24032115
49MP0002419_abnormal_innate_immunity1.23067457
50MP0002420_abnormal_adaptive_immunity1.21634548
51MP0002998_abnormal_bone_remodeling1.19527048
52MP0005310_abnormal_salivary_gland1.18099582
53MP0001819_abnormal_immune_cell1.16712908
54MP0002971_abnormal_brown_adipose1.15836646
55MP0005410_abnormal_fertilization1.13788595
56MP0005085_abnormal_gallbladder_physiolo1.13113680
57MP0001661_extended_life_span1.12867197
58MP0000372_irregular_coat_pigmentation1.11963495
59MP0001501_abnormal_sleep_pattern1.09014522
60MP0004043_abnormal_pH_regulation1.08479499
61MP0005379_endocrine/exocrine_gland_phen1.07645135
62MP0003806_abnormal_nucleotide_metabolis1.07299799
63MP0000371_diluted_coat_color1.05176005
64MP0001984_abnormal_olfaction1.04918324
65MP0000377_abnormal_hair_follicle1.02044990
66MP0005025_abnormal_response_to1.02029373
67MP0009333_abnormal_splenocyte_physiolog1.00036021
68MP0005503_abnormal_tendon_morphology0.98859577
69MP0008877_abnormal_DNA_methylation0.95495462
70MP0005365_abnormal_bile_salt0.94014700
71MP0002095_abnormal_skin_pigmentation0.93865459
72MP0001845_abnormal_inflammatory_respons0.91932209
73MP0002405_respiratory_system_inflammati0.89443230
74MP0008875_abnormal_xenobiotic_pharmacok0.88708253
75MP0010329_abnormal_lipoprotein_level0.88617711
76MP0010771_integument_phenotype0.87763164
77MP0005075_abnormal_melanosome_morpholog0.87261020
78MP0000465_gastrointestinal_hemorrhage0.87236868
79MP0005666_abnormal_adipose_tissue0.86994806
80MP0005394_taste/olfaction_phenotype0.86269864
81MP0005499_abnormal_olfactory_system0.86269864
82MP0004215_abnormal_myocardial_fiber0.85851402
83MP0003868_abnormal_feces_composition0.84566471
84MP0002234_abnormal_pharynx_morphology0.84288492
85MP0005334_abnormal_fat_pad0.82178588
86MP0003879_abnormal_hair_cell0.80924892
87MP0002060_abnormal_skin_morphology0.80865458
88MP0003300_gastrointestinal_ulcer0.79362763
89MP0010307_abnormal_tumor_latency0.77116546
90MP0003699_abnormal_female_reproductive0.76381162
91MP0000716_abnormal_immune_system0.75146830
92MP0000749_muscle_degeneration0.75107797
93MP0000689_abnormal_spleen_morphology0.73671844
94MP0002118_abnormal_lipid_homeostasis0.73577339
95MP0002098_abnormal_vibrissa_morphology0.72406433
96MP0003011_delayed_dark_adaptation0.72397609
97MP0008469_abnormal_protein_level0.71730542
98MP0000569_abnormal_digit_pigmentation0.71691415
99MP0005174_abnormal_tail_pigmentation0.69894371
100MP0009764_decreased_sensitivity_to0.69525233

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)4.19675643
2Increased IgE level (HP:0003212)3.91787802
3Erythroderma (HP:0001019)3.69170426
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.65555097
5Abnormality of secondary sexual hair (HP:0009888)3.64150458
6Abnormality of the axillary hair (HP:0100134)3.64150458
7Fair hair (HP:0002286)3.63284395
8Congenital ichthyosiform erythroderma (HP:0007431)3.62593429
9Thick nail (HP:0001805)3.56826349
10Oral leukoplakia (HP:0002745)3.49039046
11Abnormality of nail color (HP:0100643)3.27088121
12Gangrene (HP:0100758)3.26654976
13Palmoplantar hyperkeratosis (HP:0000972)3.21770416
14Hypophosphatemic rickets (HP:0004912)3.14443049
15Generalized hypopigmentation of hair (HP:0011358)3.08355348
16Parakeratosis (HP:0001036)3.06666600
17Erythema (HP:0010783)2.99953864
18Palmar hyperkeratosis (HP:0010765)2.98571505
19Hypotrichosis (HP:0001006)2.86868121
20Duplicated collecting system (HP:0000081)2.84156385
21Autoimmune thrombocytopenia (HP:0001973)2.72462421
22Conjunctival hamartoma (HP:0100780)2.67047783
23Autoimmune hemolytic anemia (HP:0001890)2.63561253
24Abnormality of the renal collecting system (HP:0004742)2.61637863
25Eczematoid dermatitis (HP:0000976)2.58272296
26Complement deficiency (HP:0004431)2.55737779
27Plantar hyperkeratosis (HP:0007556)2.51443997
28Keratoconjunctivitis sicca (HP:0001097)2.39676572
29Alopecia of scalp (HP:0002293)2.38090648
30Pustule (HP:0200039)2.37778497
31Supernumerary spleens (HP:0009799)2.35624957
32Systemic lupus erythematosus (HP:0002725)2.35296282
33Ectropion (HP:0000656)2.31760697
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30211523
35Abnormality of the prostate (HP:0008775)2.29522756
36Vacuolated lymphocytes (HP:0001922)2.29218454
37Keratoconjunctivitis (HP:0001096)2.28566988
38Abnormality of liposaccharide metabolism (HP:0010968)2.27842741
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.27842741
40Abnormality of glycolipid metabolism (HP:0010969)2.27842741
41Chronic diarrhea (HP:0002028)2.25722626
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25318961
43Pruritus (HP:0000989)2.24880779
44Prostate neoplasm (HP:0100787)2.24804355
45Abnormality of T cell number (HP:0011839)2.24284770
46Corneal erosion (HP:0200020)2.23789466
47T lymphocytopenia (HP:0005403)2.17640087
48Metaphyseal irregularity (HP:0003025)2.13200913
49Optic neuritis (HP:0100653)2.11529437
50Retrobulbar optic neuritis (HP:0100654)2.11529437
51Malnutrition (HP:0004395)2.11434735
52Hypoplasia of the fovea (HP:0007750)2.10353832
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.10353832
54Hemoptysis (HP:0002105)2.06368574
55Intrahepatic cholestasis (HP:0001406)2.05051853
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04888400
57Dry hair (HP:0011359)2.04136892
58Hyporeflexia of lower limbs (HP:0002600)2.02200315
59Lower limb hyperreflexia (HP:0002395)1.98217534
60Onycholysis (HP:0001806)1.98114481
61Anhidrosis (HP:0000970)1.97181924
62Furrowed tongue (HP:0000221)1.97139181
63Pulmonary infiltrates (HP:0002113)1.95984513
64Metaphyseal dysplasia (HP:0100255)1.94614741
65Abnormality of macrophages (HP:0004311)1.94507676
66Abnormality of the renal cortex (HP:0011035)1.94427016
67Recurrent bronchitis (HP:0002837)1.91400448
68Stomatitis (HP:0010280)1.91058254
69Hypohidrosis (HP:0000966)1.90750770
70Hematochezia (HP:0002573)1.89424537
71Hamartoma of the eye (HP:0010568)1.89290632
72Palmoplantar keratoderma (HP:0000982)1.86952014
73Gaze-evoked nystagmus (HP:0000640)1.86528595
74Steatorrhea (HP:0002570)1.85700625
75Cranial hyperostosis (HP:0004437)1.85528391
76Facial diplegia (HP:0001349)1.82381934
77Basal ganglia calcification (HP:0002135)1.81433579
78Spontaneous hematomas (HP:0007420)1.80611891
79Tubulointerstitial fibrosis (HP:0005576)1.79479615
80Recurrent bacterial skin infections (HP:0005406)1.78265135
81Craniofacial hyperostosis (HP:0004493)1.76534553
82Polyneuropathy (HP:0001271)1.75817916
83Generalized aminoaciduria (HP:0002909)1.75654799
84Loss of speech (HP:0002371)1.75482412
85Glomerulonephritis (HP:0000099)1.75063936
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74718929
87Depressed nasal tip (HP:0000437)1.74647709
88Macular degeneration (HP:0000608)1.73198371
89Recurrent gram-negative bacterial infections (HP:0005420)1.72377820
90Increased cerebral lipofuscin (HP:0011813)1.70614712
91Rickets (HP:0002748)1.69613484
92Popliteal pterygium (HP:0009756)1.69485972
93Pancreatic cysts (HP:0001737)1.68780627
94Abnormality of the fovea (HP:0000493)1.68642000
95Abnormality of the basal ganglia (HP:0002134)1.68348641
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.68172050
97IgG deficiency (HP:0004315)1.67640148
98Abnormality of complement system (HP:0005339)1.66108690
99Premature loss of primary teeth (HP:0006323)1.66050172
100Vasculitis (HP:0002633)1.65904100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.11575073
2FRK4.32509214
3MAP3K133.95371518
4TXK3.40529926
5PINK13.12011729
6EIF2AK32.77796100
7MAPKAPK32.74868276
8MST42.72218498
9MAP3K92.66565533
10TAOK32.37398720
11OBSCN2.10767037
12TRPM71.93533122
13NEK91.87663241
14FER1.86746266
15TGFBR11.66061646
16CAMKK21.63912565
17NLK1.49589187
18BMPR1B1.49450236
19NEK61.49064554
20STK391.46475709
21MARK31.42344427
22STK31.41086080
23EEF2K1.40985020
24STK38L1.38409077
25PIK3CG1.37178042
26MELK1.32916136
27MOS1.27002601
28IKBKB1.23216526
29IKBKE1.22583365
30NUAK11.18196106
31ARAF1.18110708
32CSK1.15084204
33LATS11.14138715
34ACVR1B1.13756020
35JAK11.13386159
36CDK91.12003412
37MAPK121.10743337
38BLK1.08628710
39JAK31.08238446
40MAP3K141.08088275
41PRKCI1.06255876
42PRKAA21.05126956
43GRK71.01844739
44MAP2K60.97855746
45BRSK20.97052792
46MAPKAPK50.90839189
47TGFBR20.90754247
48MAPK70.89370171
49MAP3K60.86275858
50PRKCQ0.84842164
51CCNB10.84096356
52OXSR10.83290514
53ZAK0.81910151
54ADRBK20.80860830
55INSRR0.80542471
56MAP4K10.80102701
57TYK20.76396137
58MAP3K30.73828848
59ITK0.73797995
60KIT0.72260677
61IRAK10.67142337
62TLK10.66707267
63EPHA30.61903982
64MAP3K20.61361222
65FGFR30.61291249
66CHUK0.60238460
67TNK20.60076739
68TIE10.59136044
69CAMK1D0.57008932
70MUSK0.55156574
71BMPR20.53922795
72TEC0.53914644
73IRAK40.51646437
74IGF1R0.50844233
75GRK10.50372824
76JAK20.48610828
77SYK0.47797531
78STK100.46673903
79LCK0.46107872
80PAK30.46008111
81TYRO30.45928002
82SGK20.44775348
83WNK10.44255250
84MYLK0.40477364
85CAMK40.39991281
86TBK10.39964909
87MAPK110.39210895
88ABL10.38930734
89MAP3K10.36699749
90ERBB30.35591643
91FGFR10.35398089
92CAMK10.32508592
93ADRBK10.32189916
94HCK0.32142460
95MAP3K50.30668196
96MAP3K70.30623053
97IRAK30.30556090
98BTK0.30363154
99MAP2K10.30073925
100RPS6KB10.28822815

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.75190956
2Autoimmune thyroid disease_Homo sapiens_hsa053202.64894181
3Circadian rhythm_Homo sapiens_hsa047102.60517195
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52526740
5Allograft rejection_Homo sapiens_hsa053302.49369662
6Linoleic acid metabolism_Homo sapiens_hsa005912.43558912
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34293925
8Graft-versus-host disease_Homo sapiens_hsa053322.31332311
9Primary immunodeficiency_Homo sapiens_hsa053402.29254258
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.27429098
11Asthma_Homo sapiens_hsa053102.22658880
12Caffeine metabolism_Homo sapiens_hsa002322.08045766
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.99377630
14PPAR signaling pathway_Homo sapiens_hsa033201.95447477
15Ovarian steroidogenesis_Homo sapiens_hsa049131.93075596
16ABC transporters_Homo sapiens_hsa020101.89608933
17Histidine metabolism_Homo sapiens_hsa003401.82253041
18Rheumatoid arthritis_Homo sapiens_hsa053231.71858264
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70299269
20Dorso-ventral axis formation_Homo sapiens_hsa043201.65648563
21Complement and coagulation cascades_Homo sapiens_hsa046101.64659029
22Tryptophan metabolism_Homo sapiens_hsa003801.55290133
23Hematopoietic cell lineage_Homo sapiens_hsa046401.53037774
24T cell receptor signaling pathway_Homo sapiens_hsa046601.51217720
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50107781
26beta-Alanine metabolism_Homo sapiens_hsa004101.43086630
27Type I diabetes mellitus_Homo sapiens_hsa049401.42229182
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40543835
29Chemical carcinogenesis_Homo sapiens_hsa052041.33704771
30Retinol metabolism_Homo sapiens_hsa008301.30039108
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.29513467
32Arachidonic acid metabolism_Homo sapiens_hsa005901.27116542
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26703164
34Basal transcription factors_Homo sapiens_hsa030221.26567293
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22802039
36Fatty acid degradation_Homo sapiens_hsa000711.20256109
37Ether lipid metabolism_Homo sapiens_hsa005651.18817381
38Lysosome_Homo sapiens_hsa041421.18440948
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.16186365
40Measles_Homo sapiens_hsa051621.12867597
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11021427
42Osteoclast differentiation_Homo sapiens_hsa043801.09948648
43Antigen processing and presentation_Homo sapiens_hsa046121.09411699
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.09138025
45Fatty acid elongation_Homo sapiens_hsa000621.08750952
46Phagosome_Homo sapiens_hsa041451.02766882
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02007771
48Phototransduction_Homo sapiens_hsa047441.01515723
49Viral myocarditis_Homo sapiens_hsa054160.99677080
50Phenylalanine metabolism_Homo sapiens_hsa003600.99323245
51Butanoate metabolism_Homo sapiens_hsa006500.97700568
52Sphingolipid metabolism_Homo sapiens_hsa006000.93199233
53Tuberculosis_Homo sapiens_hsa051520.91543238
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89593059
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89284424
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81724459
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79954964
58Malaria_Homo sapiens_hsa051440.77407966
59Glycerolipid metabolism_Homo sapiens_hsa005610.77286985
60Pertussis_Homo sapiens_hsa051330.77241988
61Herpes simplex infection_Homo sapiens_hsa051680.75920100
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.74249882
63Propanoate metabolism_Homo sapiens_hsa006400.70140347
64Leishmaniasis_Homo sapiens_hsa051400.70060799
65TNF signaling pathway_Homo sapiens_hsa046680.69038305
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68453252
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67646298
68Tyrosine metabolism_Homo sapiens_hsa003500.66650368
69Chemokine signaling pathway_Homo sapiens_hsa040620.66221050
70B cell receptor signaling pathway_Homo sapiens_hsa046620.60431365
71Influenza A_Homo sapiens_hsa051640.59526585
72Olfactory transduction_Homo sapiens_hsa047400.59355907
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58844354
74Collecting duct acid secretion_Homo sapiens_hsa049660.58270111
75Insulin resistance_Homo sapiens_hsa049310.58053508
76RNA degradation_Homo sapiens_hsa030180.57293694
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54737334
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53488596
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53058313
80Toxoplasmosis_Homo sapiens_hsa051450.51649665
81Sulfur metabolism_Homo sapiens_hsa009200.46184701
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.44960704
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.43435147
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41524542
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41405774
86Platelet activation_Homo sapiens_hsa046110.40939039
87Nitrogen metabolism_Homo sapiens_hsa009100.40256295
88Oxytocin signaling pathway_Homo sapiens_hsa049210.40217164
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38880817
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.37613816
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36126062
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.35300861
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.34776030
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.34424152
95Systemic lupus erythematosus_Homo sapiens_hsa053220.33990505
96Mineral absorption_Homo sapiens_hsa049780.33174156
97FoxO signaling pathway_Homo sapiens_hsa040680.32412494
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31869123
99Peroxisome_Homo sapiens_hsa041460.30607165
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30508822

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