TPM3P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)4.39070099
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.33675504
3regulation of translation, ncRNA-mediated (GO:0045974)4.33675504
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.33675504
5DNA double-strand break processing (GO:0000729)4.25484124
6prenylation (GO:0097354)3.91331623
7protein prenylation (GO:0018342)3.91331623
8transcription from mitochondrial promoter (GO:0006390)3.73689281
9signal peptide processing (GO:0006465)3.68244002
10RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.62198428
11DNA deamination (GO:0045006)3.58821533
12respiratory chain complex IV assembly (GO:0008535)3.54148375
13recombinational repair (GO:0000725)3.48343435
14double-strand break repair via homologous recombination (GO:0000724)3.47298857
15positive regulation of granulocyte differentiation (GO:0030854)3.38498917
16response to pheromone (GO:0019236)3.36633474
17histone mRNA catabolic process (GO:0071044)3.26328943
18monoubiquitinated protein deubiquitination (GO:0035520)3.24929556
19replication fork processing (GO:0031297)3.23820289
20ribosome assembly (GO:0042255)3.23239014
21platelet dense granule organization (GO:0060155)3.16940439
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16324470
23gene silencing by RNA (GO:0031047)3.12002739
24cytochrome complex assembly (GO:0017004)3.10368213
25rRNA modification (GO:0000154)3.07845059
26rRNA methylation (GO:0031167)3.04198270
27DNA catabolic process, exonucleolytic (GO:0000738)2.98835031
28regulation of memory T cell differentiation (GO:0043380)2.91848141
29positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.86825422
30postreplication repair (GO:0006301)2.82524771
31adenosine metabolic process (GO:0046085)2.82298912
32positive regulation of DNA recombination (GO:0045911)2.80982619
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78826027
34rRNA catabolic process (GO:0016075)2.76277672
35positive regulation of megakaryocyte differentiation (GO:0045654)2.75617123
36interkinetic nuclear migration (GO:0022027)2.73888170
37cellular response to ethanol (GO:0071361)2.73302658
38positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.72658567
39photoreceptor cell maintenance (GO:0045494)2.71148851
40mitochondrial RNA metabolic process (GO:0000959)2.69351819
41piRNA metabolic process (GO:0034587)2.69231581
42negative regulation of DNA-dependent DNA replication (GO:2000104)2.62911276
43positive regulation of interleukin-17 production (GO:0032740)2.62262840
44indole-containing compound catabolic process (GO:0042436)2.61403293
45indolalkylamine catabolic process (GO:0046218)2.61403293
46tryptophan catabolic process (GO:0006569)2.61403293
47meiotic chromosome segregation (GO:0045132)2.59828310
48DNA demethylation (GO:0080111)2.57039228
49snRNA transcription (GO:0009301)2.57009493
50regulation of regulatory T cell differentiation (GO:0045589)2.56913427
51double-strand break repair (GO:0006302)2.56329661
52establishment of protein localization to Golgi (GO:0072600)2.54030478
53tryptophan metabolic process (GO:0006568)2.51742460
54peptidyl-lysine trimethylation (GO:0018023)2.51468134
55somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50996531
56isotype switching (GO:0045190)2.50996531
57somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50996531
58histone H3-K9 methylation (GO:0051567)2.50145746
59positive regulation of alpha-beta T cell proliferation (GO:0046641)2.48032940
60L-fucose catabolic process (GO:0042355)2.47949641
61fucose catabolic process (GO:0019317)2.47949641
62L-fucose metabolic process (GO:0042354)2.47949641
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47691105
64neural tube formation (GO:0001841)2.47625104
65positive regulation of histone H3-K4 methylation (GO:0051571)2.47357693
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46340393
67indolalkylamine metabolic process (GO:0006586)2.45711571
68histone mRNA metabolic process (GO:0008334)2.44832373
69ncRNA catabolic process (GO:0034661)2.44816550
70regulation of meiosis I (GO:0060631)2.42613872
71DNA integration (GO:0015074)2.41246117
72kynurenine metabolic process (GO:0070189)2.40938364
73histone H3-K4 trimethylation (GO:0080182)2.39160293
74reciprocal DNA recombination (GO:0035825)2.38628201
75reciprocal meiotic recombination (GO:0007131)2.38628201
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38277336
77cellular biogenic amine catabolic process (GO:0042402)2.38261723
78amine catabolic process (GO:0009310)2.38261723
79microtubule anchoring (GO:0034453)2.37321971
80positive regulation of developmental pigmentation (GO:0048087)2.36617589
81centriole replication (GO:0007099)2.35840010
82DNA methylation involved in gamete generation (GO:0043046)2.35434757
83mannosylation (GO:0097502)2.33754717
84regulation of cilium movement (GO:0003352)2.31820022
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.31794089
86regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.31584465
87positive regulation of isotype switching (GO:0045830)2.31189950
88S-adenosylmethionine metabolic process (GO:0046500)2.31141933
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.29523234
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.29523234
91histone H2A acetylation (GO:0043968)2.28711812
92RNA phosphodiester bond hydrolysis (GO:0090501)2.28298687
93transcription elongation from RNA polymerase I promoter (GO:0006362)2.27043962
94regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.26211943
95auditory receptor cell stereocilium organization (GO:0060088)2.25961730
96axoneme assembly (GO:0035082)2.25686590
97peptidyl-lysine methylation (GO:0018022)2.24846097
98DNA recombination (GO:0006310)2.24376959
99keratinocyte development (GO:0003334)2.24142005
100pre-miRNA processing (GO:0031054)2.23774714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.31361920
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70780003
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.57732248
4VDR_22108803_ChIP-Seq_LS180_Human2.57652243
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.45594039
6ELK1_19687146_ChIP-ChIP_HELA_Human2.36948804
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.36631891
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.27655763
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.24722401
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15014602
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12979756
12EWS_26573619_Chip-Seq_HEK293_Human2.12026051
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09053503
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06322076
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05546377
16VDR_23849224_ChIP-Seq_CD4+_Human2.03131849
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01958561
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00584738
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98146756
20IGF1R_20145208_ChIP-Seq_DFB_Human1.94539404
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.89738087
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84925168
23FUS_26573619_Chip-Seq_HEK293_Human1.82774580
24P300_19829295_ChIP-Seq_ESCs_Human1.80106983
25E2F7_22180533_ChIP-Seq_HELA_Human1.78043889
26FOXP3_21729870_ChIP-Seq_TREG_Human1.72490817
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70376306
28ER_23166858_ChIP-Seq_MCF-7_Human1.69808976
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66530441
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66164177
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64482907
32GBX2_23144817_ChIP-Seq_PC3_Human1.62926121
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61842968
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61584822
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51914617
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47661115
37TAF15_26573619_Chip-Seq_HEK293_Human1.46446222
38IRF1_19129219_ChIP-ChIP_H3396_Human1.45977513
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45406854
40TP53_22573176_ChIP-Seq_HFKS_Human1.45300475
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40269641
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38609793
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36761583
44GATA3_26560356_Chip-Seq_TH2_Human1.35825469
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35709860
46CBP_20019798_ChIP-Seq_JUKART_Human1.34867610
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34867610
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33822476
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33712635
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.33660476
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32845367
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29694273
53MYC_18940864_ChIP-ChIP_HL60_Human1.27584301
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24329400
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23894857
56TCF4_23295773_ChIP-Seq_U87_Human1.23616259
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.23266470
58BCAT_22108803_ChIP-Seq_LS180_Human1.22164411
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22017550
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20877905
61STAT3_23295773_ChIP-Seq_U87_Human1.20161021
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.20139379
63MYB_26560356_Chip-Seq_TH2_Human1.19991906
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19713113
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19583095
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.18836983
67SOX2_19829295_ChIP-Seq_ESCs_Human1.18061039
68NANOG_19829295_ChIP-Seq_ESCs_Human1.18061039
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17884279
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.13395283
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13067568
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12050260
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10049114
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09828037
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06727303
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.05264352
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04693145
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04411583
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.04411583
80SCL_19346495_ChIP-Seq_HPC-7_Human1.03447048
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03031828
82GATA3_27048872_Chip-Seq_THYMUS_Human1.02945036
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.02253604
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02175335
85TCF4_22108803_ChIP-Seq_LS180_Human1.01693583
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00618667
87CIITA_25753668_ChIP-Seq_RAJI_Human1.00175438
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99950383
89SMAD_19615063_ChIP-ChIP_OVARY_Human0.99853404
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.99737014
91AR_25329375_ChIP-Seq_VCAP_Human0.99539538
92FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99255567
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.98696895
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98577234
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98286385
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98171569
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96777063
98GATA3_26560356_Chip-Seq_TH1_Human0.96722192
99CDX2_22108803_ChIP-Seq_LS180_Human0.96677419
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.96210626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.42545255
2MP0008877_abnormal_DNA_methylation3.23723564
3MP0003195_calcinosis2.61110273
4MP0008058_abnormal_DNA_repair2.53643357
5MP0003693_abnormal_embryo_hatching2.49739354
6MP0000569_abnormal_digit_pigmentation2.36022763
7MP0000372_irregular_coat_pigmentation2.20786547
8MP0010094_abnormal_chromosome_stability2.16220670
9MP0006054_spinal_hemorrhage2.14047090
10MP0001835_abnormal_antigen_presentation2.12366649
11MP0003786_premature_aging2.03863996
12MP0000516_abnormal_urinary_system2.00311280
13MP0005367_renal/urinary_system_phenotyp2.00311280
14MP0003718_maternal_effect1.97099337
15MP0005075_abnormal_melanosome_morpholog1.92757630
16MP0005646_abnormal_pituitary_gland1.88086003
17MP0009697_abnormal_copulation1.73377756
18MP0003763_abnormal_thymus_physiology1.71969078
19MP0000015_abnormal_ear_pigmentation1.70798899
20MP0005310_abnormal_salivary_gland1.70129473
21MP0005671_abnormal_response_to1.56219793
22MP0008995_early_reproductive_senescence1.54437952
23MP0003646_muscle_fatigue1.50131161
24MP0002254_reproductive_system_inflammat1.48820946
25MP0002148_abnormal_hypersensitivity_rea1.48445463
26MP0001800_abnormal_humoral_immune1.42178043
27MP0004381_abnormal_hair_follicle1.40517900
28MP0005174_abnormal_tail_pigmentation1.37298688
29MP0001873_stomach_inflammation1.33192303
30MP0005551_abnormal_eye_electrophysiolog1.30415536
31MP0003077_abnormal_cell_cycle1.28561257
32MP0000689_abnormal_spleen_morphology1.26315413
33MP0005645_abnormal_hypothalamus_physiol1.23054629
34MP0001501_abnormal_sleep_pattern1.19676182
35MP0006035_abnormal_mitochondrial_morpho1.17346048
36MP0002102_abnormal_ear_morphology1.16333277
37MP0004147_increased_porphyrin_level1.16131917
38MP0008007_abnormal_cellular_replicative1.14597387
39MP0002398_abnormal_bone_marrow1.14384039
40MP0000383_abnormal_hair_follicle1.13299745
41MP0002736_abnormal_nociception_after1.13068514
42MP0005266_abnormal_metabolism1.12548615
43MP0003111_abnormal_nucleus_morphology1.11363017
44MP0002396_abnormal_hematopoietic_system1.09634489
45MP0002452_abnormal_antigen_presenting1.08282272
46MP0001853_heart_inflammation1.07180596
47MP0002723_abnormal_immune_serum1.07060095
48MP0001929_abnormal_gametogenesis1.06732589
49MP0003806_abnormal_nucleotide_metabolis1.06644488
50MP0010307_abnormal_tumor_latency1.04856433
51MP0000371_diluted_coat_color1.04684034
52MP0003943_abnormal_hepatobiliary_system1.04260918
53MP0005395_other_phenotype1.03885036
54MP0004264_abnormal_extraembryonic_tissu1.03027559
55MP0002095_abnormal_skin_pigmentation1.02753228
56MP0005647_abnormal_sex_gland1.02417011
57MP0002837_dystrophic_cardiac_calcinosis1.02010444
58MP0001545_abnormal_hematopoietic_system1.01845261
59MP0005397_hematopoietic_system_phenotyp1.01845261
60MP0002166_altered_tumor_susceptibility1.01578122
61MP0000427_abnormal_hair_cycle1.00607463
62MP0005000_abnormal_immune_tolerance0.99972206
63MP0002420_abnormal_adaptive_immunity0.99090157
64MP0005387_immune_system_phenotype0.98336667
65MP0001790_abnormal_immune_system0.98336667
66MP0002405_respiratory_system_inflammati0.97733847
67MP0004808_abnormal_hematopoietic_stem0.97421570
68MP0001819_abnormal_immune_cell0.96958230
69MP0002722_abnormal_immune_system0.95092421
70MP0005187_abnormal_penis_morphology0.94575435
71MP0000703_abnormal_thymus_morphology0.94069663
72MP0001986_abnormal_taste_sensitivity0.93760125
73MP0001119_abnormal_female_reproductive0.92534587
74MP0008872_abnormal_physiological_respon0.90308743
75MP0005253_abnormal_eye_physiology0.89915919
76MP0000647_abnormal_sebaceous_gland0.89715111
77MP0000716_abnormal_immune_system0.89597689
78MP0002210_abnormal_sex_determination0.89114084
79MP0001764_abnormal_homeostasis0.89088116
80MP0001919_abnormal_reproductive_system0.86727681
81MP0003656_abnormal_erythrocyte_physiolo0.86384794
82MP0000653_abnormal_sex_gland0.86273499
83MP0001968_abnormal_touch/_nociception0.86015845
84MP0003787_abnormal_imprinting0.84512330
85MP0004957_abnormal_blastocyst_morpholog0.84444216
86MP0001145_abnormal_male_reproductive0.82792423
87MP0002876_abnormal_thyroid_physiology0.81194984
88MP0003567_abnormal_fetal_cardiomyocyte0.80730803
89MP0009764_decreased_sensitivity_to0.78565396
90MP0002429_abnormal_blood_cell0.78124606
91MP0005220_abnormal_exocrine_pancreas0.76208297
92MP0005389_reproductive_system_phenotype0.76180525
93MP0002006_tumorigenesis0.75704987
94MP0002009_preneoplasia0.74804003
95MP0005083_abnormal_biliary_tract0.73859028
96MP0009785_altered_susceptibility_to0.73632665
97MP0005332_abnormal_amino_acid0.71894726
98MP0002163_abnormal_gland_morphology0.71759028
99MP0005084_abnormal_gallbladder_morpholo0.71648054
100MP0000538_abnormal_urinary_bladder0.71566168

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)3.67263168
2Pancreatic cysts (HP:0001737)3.26824162
33-Methylglutaconic aciduria (HP:0003535)3.15420642
4Methylmalonic acidemia (HP:0002912)2.94709837
5Abnormality of chromosome stability (HP:0003220)2.85243020
6Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70265487
7Renal cortical cysts (HP:0000803)2.68184507
8Abnormality of the ileum (HP:0001549)2.66270903
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.65595209
10Gaze-evoked nystagmus (HP:0000640)2.63359133
11Chromsome breakage (HP:0040012)2.63306081
12Hyperventilation (HP:0002883)2.61840752
13Clubbing of toes (HP:0100760)2.60530300
14Meckel diverticulum (HP:0002245)2.57716458
15Abnormality of the preputium (HP:0100587)2.51356737
16Thyroiditis (HP:0100646)2.48931788
17Abnormality of the renal cortex (HP:0011035)2.46792308
18Severe combined immunodeficiency (HP:0004430)2.40980979
19Abnormality of midbrain morphology (HP:0002418)2.36722784
20Molar tooth sign on MRI (HP:0002419)2.36722784
21Stomatitis (HP:0010280)2.36622812
22Attenuation of retinal blood vessels (HP:0007843)2.35350119
23Pancreatic fibrosis (HP:0100732)2.33176599
24Abnormality of B cell number (HP:0010975)2.30527505
25Type I transferrin isoform profile (HP:0003642)2.30444477
26Abnormality of the vitamin B12 metabolism (HP:0004341)2.27085121
27Methylmalonic aciduria (HP:0012120)2.26568030
28Abnormality of vitamin B metabolism (HP:0004340)2.25751419
29Abnormality of T cell number (HP:0011839)2.24461733
30Central scotoma (HP:0000603)2.23514319
31True hermaphroditism (HP:0010459)2.21708594
32T lymphocytopenia (HP:0005403)2.21399616
33Abolished electroretinogram (ERG) (HP:0000550)2.21148420
34Facial diplegia (HP:0001349)2.19251279
35Medial flaring of the eyebrow (HP:0010747)2.17855986
36Abnormal protein glycosylation (HP:0012346)2.16767552
37Abnormal glycosylation (HP:0012345)2.16767552
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16767552
39Abnormal protein N-linked glycosylation (HP:0012347)2.16767552
40Intestinal atresia (HP:0011100)2.15979571
41Nephronophthisis (HP:0000090)2.13933804
42Sloping forehead (HP:0000340)2.12622832
43Genetic anticipation (HP:0003743)2.12362781
44Progressive inability to walk (HP:0002505)2.10756078
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08522896
46Abnormality of alanine metabolism (HP:0010916)2.08522896
47Hyperalaninemia (HP:0003348)2.08522896
48Albinism (HP:0001022)2.07972720
49Chronic hepatic failure (HP:0100626)2.04387153
50Abnormality of the renal medulla (HP:0100957)2.03349364
51IgG deficiency (HP:0004315)2.02980389
52Hypothermia (HP:0002045)2.02286202
53Panhypogammaglobulinemia (HP:0003139)2.00440132
54Acute myeloid leukemia (HP:0004808)1.98492391
55Combined immunodeficiency (HP:0005387)1.97838831
56Prostate neoplasm (HP:0100787)1.96844259
57Abnormality of macular pigmentation (HP:0008002)1.96554661
58Myelodysplasia (HP:0002863)1.94744501
59Colon cancer (HP:0003003)1.94570898
60Duodenal stenosis (HP:0100867)1.92371875
61Small intestinal stenosis (HP:0012848)1.92371875
62Congenital stationary night blindness (HP:0007642)1.92240044
63Chronic diarrhea (HP:0002028)1.90239475
64Cupped ear (HP:0000378)1.89763759
65Widely spaced teeth (HP:0000687)1.89466914
66Abnormal biliary tract physiology (HP:0012439)1.88941467
67Bile duct proliferation (HP:0001408)1.88941467
68Neoplasm of the tracheobronchial system (HP:0100552)1.88131201
69Alveolar cell carcinoma (HP:0006519)1.86856984
70B lymphocytopenia (HP:0010976)1.86085030
71Prominent nose (HP:0000448)1.85645014
72Fair hair (HP:0002286)1.84461418
73Nephroblastoma (Wilms tumor) (HP:0002667)1.83946358
74Increased serum lactate (HP:0002151)1.82648732
75Abnormality of the duodenum (HP:0002246)1.81263850
76Volvulus (HP:0002580)1.80080274
77Pendular nystagmus (HP:0012043)1.79045559
78Ectopic kidney (HP:0000086)1.78930726
79Microvesicular hepatic steatosis (HP:0001414)1.78258149
80Abnormality of eosinophils (HP:0001879)1.77273685
81Abnormality of the prostate (HP:0008775)1.76422547
82Abnormality of the axillary hair (HP:0100134)1.75890509
83Abnormality of secondary sexual hair (HP:0009888)1.75890509
84Abnormality of T cells (HP:0002843)1.75319079
85Dyschromatopsia (HP:0007641)1.74697506
86Abnormal delayed hypersensitivity skin test (HP:0002963)1.73791361
87Absent speech (HP:0001344)1.73695893
88Astigmatism (HP:0000483)1.73467133
89Abnormality of the parathyroid morphology (HP:0011766)1.73180655
90Embryonal renal neoplasm (HP:0011794)1.72544980
91Severe visual impairment (HP:0001141)1.72540523
92Autoimmune hemolytic anemia (HP:0001890)1.69444518
93Clumsiness (HP:0002312)1.69249785
94Spontaneous abortion (HP:0005268)1.68443966
95Tented upper lip vermilion (HP:0010804)1.67333870
96Abnormality of the pons (HP:0007361)1.65511844
97Elevated erythrocyte sedimentation rate (HP:0003565)1.64922087
98Neutropenia (HP:0001875)1.64315742
99Cerebellar dysplasia (HP:0007033)1.62656655
100Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62538016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.51786196
2NUAK13.24828722
3MST43.04134266
4TRIM282.53785371
5LATS12.37535216
6ACVR1B2.22619682
7BRSK22.20190129
8EIF2AK32.13918271
9BMPR1B2.11058922
10TXK2.04410986
11TAOK31.95660504
12AKT31.93620719
13MKNK21.86094298
14INSRR1.83420975
15ZAK1.77150034
16TNIK1.69205857
17SRPK11.65463258
18STK38L1.63782894
19WNK31.56620154
20BRD41.55862358
21TEC1.47023805
22MAP4K21.46412592
23VRK21.45579438
24ADRBK21.41325963
25PDK21.34479512
26MAP4K11.30785946
27GRK11.28456549
28TAF11.27474324
29PIK3CG1.25716005
30NLK1.23754026
31PBK1.21653939
32TESK21.15271224
33STK391.12772378
34BUB11.12573929
35STK31.03504586
36WNK41.03070007
37CAMK1D1.03019429
38PAK31.02461989
39IKBKB1.00696887
40TNK20.99396234
41ATR0.96075141
42MARK30.96002579
43OXSR10.93349750
44MKNK10.90935598
45BMPR20.85936503
46TLK10.85072647
47EIF2AK20.84649795
48CHUK0.84498609
49VRK10.83942192
50CSNK1G10.83248454
51NME10.83205187
52STK100.80007469
53MAPK130.79720769
54ITK0.79666375
55CAMK1G0.78562067
56PLK40.77926635
57PLK30.77020620
58CSNK1A1L0.76223762
59STK40.75649188
60SIK30.74087403
61CLK10.73637266
62TGFBR10.70332326
63FLT30.68234228
64BCR0.67726584
65ERBB30.67588925
66ATM0.65937808
67FER0.63387260
68CAMKK20.62728247
69FGFR10.62131433
70SYK0.62073698
71GRK70.61856664
72BTK0.61509482
73PRKCE0.56299038
74PLK10.55021154
75PRKAA20.54875532
76WEE10.53884294
77ADRBK10.53358256
78CDK120.52225759
79PRKCQ0.51884678
80LYN0.50455008
81MAP3K140.48962934
82CASK0.48927411
83LCK0.47594951
84CSNK1G30.47426506
85PLK20.46614454
86EIF2AK10.45639415
87JAK10.44852723
88IKBKE0.43918030
89KIT0.43429728
90PRKCI0.43358096
91MAP3K40.42435198
92DAPK10.42119662
93CDC70.41311766
94CHEK10.41133993
95ABL10.41094626
96TSSK60.40257432
97BCKDK0.40062648
98RPS6KA50.39487919
99DAPK20.37521661
100RPS6KA40.36248687

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62933248
2Homologous recombination_Homo sapiens_hsa034403.17995576
3Fanconi anemia pathway_Homo sapiens_hsa034602.76019281
4Basal transcription factors_Homo sapiens_hsa030222.67425908
5Non-homologous end-joining_Homo sapiens_hsa034502.54615642
6Proteasome_Homo sapiens_hsa030502.49624694
7RNA polymerase_Homo sapiens_hsa030202.34022372
8Asthma_Homo sapiens_hsa053102.13947949
9Propanoate metabolism_Homo sapiens_hsa006402.05818438
10Graft-versus-host disease_Homo sapiens_hsa053322.02530074
11RNA degradation_Homo sapiens_hsa030181.95236451
12One carbon pool by folate_Homo sapiens_hsa006701.89632190
13Selenocompound metabolism_Homo sapiens_hsa004501.88853766
14Protein export_Homo sapiens_hsa030601.88249345
15Primary immunodeficiency_Homo sapiens_hsa053401.83678263
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76348546
17Allograft rejection_Homo sapiens_hsa053301.75821592
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.73099005
19Autoimmune thyroid disease_Homo sapiens_hsa053201.70631584
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70320830
21Butanoate metabolism_Homo sapiens_hsa006501.64738633
22Type I diabetes mellitus_Homo sapiens_hsa049401.64433329
23RNA transport_Homo sapiens_hsa030131.60168600
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57317597
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53972318
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53323401
27Regulation of autophagy_Homo sapiens_hsa041401.49612033
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49276108
29Phototransduction_Homo sapiens_hsa047441.44852872
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37776764
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30084397
32Spliceosome_Homo sapiens_hsa030401.20572953
33Pyrimidine metabolism_Homo sapiens_hsa002401.16582782
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.13193280
35mRNA surveillance pathway_Homo sapiens_hsa030151.12681676
36Mismatch repair_Homo sapiens_hsa034301.07722231
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05925355
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05455754
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04652409
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01682099
41Herpes simplex infection_Homo sapiens_hsa051681.00307093
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.00158241
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99429534
44Purine metabolism_Homo sapiens_hsa002300.99067470
45Peroxisome_Homo sapiens_hsa041460.97582340
46Lysine degradation_Homo sapiens_hsa003100.96275776
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95546673
48Antigen processing and presentation_Homo sapiens_hsa046120.94889402
49Ether lipid metabolism_Homo sapiens_hsa005650.94285693
50Circadian rhythm_Homo sapiens_hsa047100.90621810
51Measles_Homo sapiens_hsa051620.86611067
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85549521
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.85003119
54Nitrogen metabolism_Homo sapiens_hsa009100.84893736
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84100740
56Rheumatoid arthritis_Homo sapiens_hsa053230.83614713
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82482590
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82112054
59Hematopoietic cell lineage_Homo sapiens_hsa046400.79808630
60p53 signaling pathway_Homo sapiens_hsa041150.79002884
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.75415628
62Legionellosis_Homo sapiens_hsa051340.74461756
63DNA replication_Homo sapiens_hsa030300.73237494
64Nucleotide excision repair_Homo sapiens_hsa034200.72640006
65Olfactory transduction_Homo sapiens_hsa047400.72460167
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72367855
67T cell receptor signaling pathway_Homo sapiens_hsa046600.71116651
68Base excision repair_Homo sapiens_hsa034100.69030227
69Cell cycle_Homo sapiens_hsa041100.68487528
70Linoleic acid metabolism_Homo sapiens_hsa005910.67251838
71Dorso-ventral axis formation_Homo sapiens_hsa043200.66682340
72ABC transporters_Homo sapiens_hsa020100.63602403
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63078047
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62188413
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61123954
76Collecting duct acid secretion_Homo sapiens_hsa049660.60746579
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.60420232
78Epstein-Barr virus infection_Homo sapiens_hsa051690.59463677
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54661783
80Chemical carcinogenesis_Homo sapiens_hsa052040.54613951
81Tryptophan metabolism_Homo sapiens_hsa003800.54609408
82beta-Alanine metabolism_Homo sapiens_hsa004100.49894617
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44745961
84Steroid biosynthesis_Homo sapiens_hsa001000.44054200
85Retinol metabolism_Homo sapiens_hsa008300.43872641
86Glutathione metabolism_Homo sapiens_hsa004800.43738869
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38532329
88Vitamin digestion and absorption_Homo sapiens_hsa049770.38003635
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35479041
90Metabolic pathways_Homo sapiens_hsa011000.34904926
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34589497
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33381180
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33250957
94Glycerolipid metabolism_Homo sapiens_hsa005610.32869703
95Taste transduction_Homo sapiens_hsa047420.32393957
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31701543
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.30240678
98Tuberculosis_Homo sapiens_hsa051520.29163634
99FoxO signaling pathway_Homo sapiens_hsa040680.28482292
100Mineral absorption_Homo sapiens_hsa049780.27581410

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