TPD52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)5.98887656
2response to redox state (GO:0051775)5.93751772
3protein maturation by protein folding (GO:0022417)4.61475020
4carbohydrate phosphorylation (GO:0046835)4.34933516
5regulation of type B pancreatic cell apoptotic process (GO:2000674)4.28085047
6negative regulation of calcium ion transport into cytosol (GO:0010523)4.20790212
7cellular ketone body metabolic process (GO:0046950)4.17505807
8negative regulation of heart rate (GO:0010459)4.14181982
9lytic vacuole organization (GO:0080171)4.08724121
10lysosome organization (GO:0007040)4.08724121
11positive regulation of regulated secretory pathway (GO:1903307)4.08486791
12magnesium ion transport (GO:0015693)4.02300884
13protein neddylation (GO:0045116)3.88287239
14autophagic vacuole fusion (GO:0000046)3.85315526
15GDP-mannose metabolic process (GO:0019673)3.83600715
16response to hydroperoxide (GO:0033194)3.75036960
17positive regulation of glycolytic process (GO:0045821)3.71929138
18insulin secretion (GO:0030073)3.71710465
19ketone body metabolic process (GO:1902224)3.71085806
20auditory receptor cell differentiation (GO:0042491)3.70004986
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61242454
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.56233612
23regulation of glucokinase activity (GO:0033131)3.54556496
24regulation of hexokinase activity (GO:1903299)3.54556496
25vacuole organization (GO:0007033)3.52894267
26glandular epithelial cell differentiation (GO:0002067)3.51000623
27cellular copper ion homeostasis (GO:0006878)3.45878186
28bundle of His cell to Purkinje myocyte communication (GO:0086069)3.45650050
29regulation of protein glycosylation (GO:0060049)3.41400498
30positive regulation of gluconeogenesis (GO:0045722)3.37160283
31positive regulation of respiratory burst (GO:0060267)3.36616385
32desmosome organization (GO:0002934)3.32607652
33detection of light stimulus involved in sensory perception (GO:0050962)3.32492904
34detection of light stimulus involved in visual perception (GO:0050908)3.32492904
35autophagic vacuole assembly (GO:0000045)3.32215108
36glycerophospholipid catabolic process (GO:0046475)3.30702223
37positive regulation of TOR signaling (GO:0032008)3.29750931
38columnar/cuboidal epithelial cell development (GO:0002066)3.29291354
39positive regulation of Cdc42 GTPase activity (GO:0043089)3.23619370
40negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.21263763
41signal peptide processing (GO:0006465)3.20817138
42glycoside metabolic process (GO:0016137)3.20321137
43chemosensory behavior (GO:0007635)3.19645174
44zinc ion homeostasis (GO:0055069)3.19581966
45detection of calcium ion (GO:0005513)3.17109913
46regulation of autophagic vacuole assembly (GO:2000785)3.15485421
47myelin maintenance (GO:0043217)3.14116174
48positive regulation of insulin secretion (GO:0032024)3.13226656
49transepithelial transport (GO:0070633)3.13177025
50regulation of early endosome to late endosome transport (GO:2000641)3.12502347
51regulation of neuron projection regeneration (GO:0070570)3.12099392
52regulation of axon regeneration (GO:0048679)3.12099392
53phenylpropanoid metabolic process (GO:0009698)3.11372867
54glutamate secretion (GO:0014047)3.08977336
55protein polyglutamylation (GO:0018095)3.08507919
56neutrophil activation involved in immune response (GO:0002283)3.08489610
57protein localization to endosome (GO:0036010)3.07263548
58sphingosine metabolic process (GO:0006670)3.04328763
59Golgi transport vesicle coating (GO:0048200)3.02020453
60COPI coating of Golgi vesicle (GO:0048205)3.02020453
61positive regulation of autophagy (GO:0010508)3.00597536
62regulation of heart rate by cardiac conduction (GO:0086091)2.98733879
63calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.98454144
64apical protein localization (GO:0045176)2.98361124
65negative regulation of hormone metabolic process (GO:0032351)2.95303859
66vesicle targeting (GO:0006903)2.95261861
67diol metabolic process (GO:0034311)2.94263267
68negative regulation of hormone biosynthetic process (GO:0032353)2.94119420
69phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.93995987
70regulation of insulin secretion (GO:0050796)2.93333662
71phasic smooth muscle contraction (GO:0014821)2.92456962
727-methylguanosine mRNA capping (GO:0006370)2.92076754
73endocrine pancreas development (GO:0031018)2.91738722
74lactate metabolic process (GO:0006089)2.90955288
75regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.89404967
76polyol catabolic process (GO:0046174)2.89350594
77L-phenylalanine metabolic process (GO:0006558)2.89143260
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.89143260
79mannose metabolic process (GO:0006013)2.89134466
80inositol phosphate dephosphorylation (GO:0046855)2.88478479
81phosphorylated carbohydrate dephosphorylation (GO:0046838)2.88478479
82inositol phosphate catabolic process (GO:0071545)2.87396076
83positive regulation of peptide hormone secretion (GO:0090277)2.87191319
84regulation of bile acid biosynthetic process (GO:0070857)2.86528294
85cellular zinc ion homeostasis (GO:0006882)2.85922822
86macroautophagy (GO:0016236)2.85824613
87phosphatidylserine acyl-chain remodeling (GO:0036150)2.83253807
88nitric oxide biosynthetic process (GO:0006809)2.83192099
89regulation of receptor recycling (GO:0001919)2.83130274
90membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.82496157
91cellular potassium ion homeostasis (GO:0030007)2.82152961
92proline transport (GO:0015824)2.81218181
93positive regulation of peptide secretion (GO:0002793)2.79692623
94intracellular pH reduction (GO:0051452)2.79557595
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.79303708
96positive regulation of actin filament depolymerization (GO:0030836)2.79122326
97protein autoprocessing (GO:0016540)2.78843875
98regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78755802
99neurotransmitter secretion (GO:0007269)2.77754353
100regulation of regulated secretory pathway (GO:1903305)2.77715815
101pteridine-containing compound biosynthetic process (GO:0042559)2.76280597
102epithelial cell fate commitment (GO:0072148)2.75633370
103cardiac conduction (GO:0061337)2.74782390
104copper ion homeostasis (GO:0055070)2.74261964
1057-methylguanosine RNA capping (GO:0009452)2.74115331
106RNA capping (GO:0036260)2.74115331
107neuronal action potential propagation (GO:0019227)2.72290835
108peptidyl-histidine modification (GO:0018202)2.69897738
109zinc ion transport (GO:0006829)2.69782697
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69550897
111pH reduction (GO:0045851)2.69219624
112positive regulation of macroautophagy (GO:0016239)2.68214421
113DNA damage induced protein phosphorylation (GO:0006975)2.66888332
114respiratory chain complex IV assembly (GO:0008535)2.65262765
115L-alpha-amino acid transmembrane transport (GO:1902475)2.65015345
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64470410
117L-phenylalanine catabolic process (GO:0006559)2.64470410
118peptide hormone secretion (GO:0030072)2.63498630
119regulation of peptide hormone secretion (GO:0090276)2.63268173
120regulation of vacuole organization (GO:0044088)2.63114193
121phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62208143
122ER overload response (GO:0006983)2.61844402
123synaptic vesicle maturation (GO:0016188)2.61713489
124sphingoid metabolic process (GO:0046519)2.61431099
125organelle membrane fusion (GO:0090174)2.60244429
126regulation of peptide secretion (GO:0002791)2.59831420
127Golgi to endosome transport (GO:0006895)2.57892694
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57774661
129sphingomyelin metabolic process (GO:0006684)2.57039241
130inositol phosphate-mediated signaling (GO:0048016)2.56947919
131negative regulation of cation channel activity (GO:2001258)2.56776619
132positive regulation of nitric-oxide synthase activity (GO:0051000)2.56694659
133membrane repolarization during action potential (GO:0086011)2.56167619
134regulation of guanylate cyclase activity (GO:0031282)2.55473667
135positive regulation of exocytosis (GO:0045921)2.54358647
136succinate metabolic process (GO:0006105)2.52359435
137negative regulation of gluconeogenesis (GO:0045721)2.51923353
138regulation of integrin-mediated signaling pathway (GO:2001044)2.51855291
139peptide secretion (GO:0002790)2.50940703
140transferrin transport (GO:0033572)2.49912970
141detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.48958823
142detection of temperature stimulus involved in sensory perception (GO:0050961)2.48958823
143nitric oxide mediated signal transduction (GO:0007263)2.48497593
144protein kinase C signaling (GO:0070528)2.48356178
145mRNA modification (GO:0016556)2.47640230
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.47117738
147positive regulation of mitochondrial membrane permeability (GO:0035794)2.46905016
148positive regulation of response to extracellular stimulus (GO:0032106)2.46432837
149positive regulation of response to nutrient levels (GO:0032109)2.46432837
150protein secretion (GO:0009306)2.46065047
151glycolipid catabolic process (GO:0019377)2.46032973
152early endosome to late endosome transport (GO:0045022)2.45412672
153phosphatidylcholine acyl-chain remodeling (GO:0036151)2.45387708
154intermediate filament-based process (GO:0045103)2.43604922
155peptidyl-cysteine modification (GO:0018198)2.43229025
156membrane budding (GO:0006900)2.42739737
157potassium ion homeostasis (GO:0055075)2.42657876
158cytochrome complex assembly (GO:0017004)2.42573322
159regulation of Rac protein signal transduction (GO:0035020)2.42321085
160water-soluble vitamin biosynthetic process (GO:0042364)2.42253708
161regulation of water loss via skin (GO:0033561)2.42182024
162intermediate filament cytoskeleton organization (GO:0045104)2.41516445
163positive regulation of epidermal cell differentiation (GO:0045606)2.41474154
164COPII vesicle coating (GO:0048208)2.41455759
165nucleotide-sugar biosynthetic process (GO:0009226)2.40677766
166positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.39166884
167intestinal absorption (GO:0050892)2.38947389
168fucose catabolic process (GO:0019317)2.38369839
169L-fucose metabolic process (GO:0042354)2.38369839
170L-fucose catabolic process (GO:0042355)2.38369839
171phagosome maturation (GO:0090382)2.38344949
172phospholipid dephosphorylation (GO:0046839)2.38044936
173zinc ion transmembrane transport (GO:0071577)2.37505175
174peripheral nervous system neuron development (GO:0048935)2.37333237
175negative regulation of execution phase of apoptosis (GO:1900118)2.36750610
176digestion (GO:0007586)2.36465445
177regulation of synaptic vesicle exocytosis (GO:2000300)2.36433789
178peptide hormone processing (GO:0016486)2.36251685
179detection of temperature stimulus (GO:0016048)2.35961196
180cellular response to ATP (GO:0071318)2.35604674
181ribosome assembly (GO:0042255)2.35601500
182ceramide catabolic process (GO:0046514)2.33317261
183urinary tract smooth muscle contraction (GO:0014848)2.32945160
184response to vitamin E (GO:0033197)2.32907179
185modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32692082
186positive regulation by organism of defense response of other organism involved in symbiotic interact2.32692082
187modulation by symbiont of host immune response (GO:0052553)2.32692082
188modulation by symbiont of host defense response (GO:0052031)2.32692082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.36113673
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33287756
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.31538444
4* NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.25521192
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.95128713
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.95128713
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.95128713
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84170764
9STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.51468391
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.42840537
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.38029073
12* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.26879190
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.26014514
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17335688
15* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.15565740
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.15473588
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03897331
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.02546257
19* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00674991
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99092503
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95681171
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93717189
23SOX2_20726797_ChIP-Seq_SW620_Human1.92052356
24* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84978877
25AR_21909140_ChIP-Seq_LNCAP_Human1.83519828
26VDR_22108803_ChIP-Seq_LS180_Human1.82979398
27HTT_18923047_ChIP-ChIP_STHdh_Human1.82343098
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.81435954
29* PIAS1_25552417_ChIP-Seq_VCAP_Human1.78659801
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.78441069
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76605046
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.75814490
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.75123124
34FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.72182891
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.70831278
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70054252
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68992300
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68783701
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67246802
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.66471960
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66184843
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62811794
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.61658158
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54176685
45* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53548758
46* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53419802
47AHR_22903824_ChIP-Seq_MCF-7_Human1.52211941
48TAF15_26573619_Chip-Seq_HEK293_Human1.51523246
49REST_21632747_ChIP-Seq_MESCs_Mouse1.50602905
50TFEB_21752829_ChIP-Seq_HELA_Human1.48859015
51GATA6_25053715_ChIP-Seq_YYC3_Human1.48068791
52* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45923811
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.45653920
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42209344
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40821101
56* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40127837
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.39493875
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.39411553
59* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38801893
60* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.37262730
61GATA4_25053715_ChIP-Seq_YYC3_Human1.35823959
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35521475
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33590906
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33375660
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.33103263
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33103263
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31351104
68ER_23166858_ChIP-Seq_MCF-7_Human1.31340180
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.31039794
70IGF1R_20145208_ChIP-Seq_DFB_Human1.29600837
71* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28885788
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28376962
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.28245183
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28226341
75ZNF263_19887448_ChIP-Seq_K562_Human1.28163475
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26927671
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26169166
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.25926568
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.23872721
80* AR_25329375_ChIP-Seq_VCAP_Human1.23355354
81TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.22860118
82ELF5_23300383_ChIP-Seq_T47D_Human1.22814887
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21016825
84* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20780330
85AR_20517297_ChIP-Seq_VCAP_Human1.19109023
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.19087541
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18831410
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18715229
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.18433994
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.17364054
91* TP53_22573176_ChIP-Seq_HFKS_Human1.16590430
92KAP1_27257070_Chip-Seq_ESCs_Mouse1.16384175
93CDX2_22108803_ChIP-Seq_LS180_Human1.16307500
94P53_22387025_ChIP-Seq_ESCs_Mouse1.16291887
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.15992153
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15827823
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15494852
98* KLF5_25053715_ChIP-Seq_YYC3_Human1.15331223
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.14175716
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.13710736
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13126638
102* GATA3_24758297_ChIP-Seq_MCF-7_Human1.13050043
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12814507
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12470276
105* TCF4_23295773_ChIP-Seq_U87_Human1.12193180
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10820988
107* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10403032
108STAT3_23295773_ChIP-Seq_U87_Human1.09718692
109TCF4_22108803_ChIP-Seq_LS180_Human1.09452929
110SMAD4_21799915_ChIP-Seq_A2780_Human1.08726930
111* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08406197
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.08298377
113* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08130238
114* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07559806
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07522250
116* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07450375
117ATF3_27146783_Chip-Seq_COLON_Human1.06880369
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.06190459
119BCAT_22108803_ChIP-Seq_LS180_Human1.05931502
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04955386
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04790060
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04740193
123PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04309710
124FUS_26573619_Chip-Seq_HEK293_Human1.04142544
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03925070
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.03740248
127* KLF4_18555785_Chip-Seq_ESCs_Mouse1.03626595
128HNF4A_19822575_ChIP-Seq_HepG2_Human1.03501954
129NANOG_19829295_ChIP-Seq_ESCs_Human1.03197646
130SOX2_19829295_ChIP-Seq_ESCs_Human1.03197646
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03183632
132* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02688721
133P300_18555785_Chip-Seq_ESCs_Mouse1.02472606
134RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01725091
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.01553197
136* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01088035
137NCOR_22424771_ChIP-Seq_293T_Human1.00909930
138STAT1_20625510_ChIP-Seq_HELA_Human1.00890592
139* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00574125
140* HOXB7_26014856_ChIP-Seq_BT474_Human1.00452968
141KDM5A_27292631_Chip-Seq_BREAST_Human0.99925578
142* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99033959
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98075589
144* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97663086
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97285375
146NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96819880
147PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96113781
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95955521
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95243680
150* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95115825
151* FOXA1_25552417_ChIP-Seq_VCAP_Human0.94864602
152SPI1_23547873_ChIP-Seq_NB4_Human0.94185499
153CJUN_26792858_Chip-Seq_BT549_Human0.92483694
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92108466
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90717150
156FOXH1_21741376_ChIP-Seq_ESCs_Human0.90443768
157PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90032613
158KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89668271
159* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89641872
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89113572
161IRF8_27001747_Chip-Seq_BMDM_Mouse0.89099306
162GATA1_26923725_Chip-Seq_HPCs_Mouse0.87856075
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.87813703
164CDX2_20551321_ChIP-Seq_CACO-2_Human0.86802430
165CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85628544
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85287911
167* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84809413
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84577285
169NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84024679
170* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82669607
171* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82139039
172* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81711952
173* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81711952
174OCT4_20526341_ChIP-Seq_ESCs_Human0.81634769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology7.46381379
2MP0005379_endocrine/exocrine_gland_phen5.35980396
3MP0009780_abnormal_chondrocyte_physiolo3.64758458
4MP0000613_abnormal_salivary_gland3.12110713
5MP0010386_abnormal_urinary_bladder2.91534417
6MP0008260_abnormal_autophagy2.87359854
7MP0002139_abnormal_hepatobiliary_system2.68261341
8MP0005220_abnormal_exocrine_pancreas2.67966640
9MP0005645_abnormal_hypothalamus_physiol2.66912455
10MP0003787_abnormal_imprinting2.57087681
11MP0003123_paternal_imprinting2.30170762
12MP0004270_analgesia2.28640198
13MP0010234_abnormal_vibrissa_follicle2.27851792
14MP0002653_abnormal_ependyma_morphology2.26673940
15MP0002876_abnormal_thyroid_physiology2.23916167
16MP0005058_abnormal_lysosome_morphology2.21338563
17MP0001986_abnormal_taste_sensitivity2.13919088
18MP0003693_abnormal_embryo_hatching2.11655880
19MP0005646_abnormal_pituitary_gland2.10757450
20MP0006072_abnormal_retinal_apoptosis2.10059094
21MP0002837_dystrophic_cardiac_calcinosis2.02414467
22MP0003183_abnormal_peptide_metabolism10.9306483
23MP0004043_abnormal_pH_regulation1.93085514
24MP0005551_abnormal_eye_electrophysiolog1.85262362
25MP0003718_maternal_effect1.84876392
26MP0004264_abnormal_extraembryonic_tissu1.80612715
27MP0000013_abnormal_adipose_tissue1.78284525
28MP0005310_abnormal_salivary_gland1.76558817
29MP0005365_abnormal_bile_salt1.75270529
30MP0005085_abnormal_gallbladder_physiolo1.65928947
31MP0003329_amyloid_beta_deposits1.64934027
32MP0003868_abnormal_feces_composition1.64389285
33MP0005332_abnormal_amino_acid1.63187657
34MP0010352_gastrointestinal_tract_polyps1.57306759
35MP0002166_altered_tumor_susceptibility1.57122137
36MP0005636_abnormal_mineral_homeostasis1.51154794
37MP0009046_muscle_twitch1.50217276
38MP0001944_abnormal_pancreas_morphology1.49325977
39MP0000462_abnormal_digestive_system1.49297528
40MP0010329_abnormal_lipoprotein_level1.45217011
41MP0001501_abnormal_sleep_pattern1.43772010
42MP0002693_abnormal_pancreas_physiology1.43477842
43MP0002822_catalepsy1.42847395
44MP0005253_abnormal_eye_physiology1.41460692
45MP0002078_abnormal_glucose_homeostasis1.41237783
46MP0002138_abnormal_hepatobiliary_system1.41011636
47MP0002272_abnormal_nervous_system1.36531193
48MP0001188_hyperpigmentation1.35792426
49MP0002734_abnormal_mechanical_nocicepti1.35105186
50MP0003866_abnormal_defecation1.30286468
51MP0002229_neurodegeneration1.29345755
52MP0002277_abnormal_respiratory_mucosa1.27299486
53MP0009745_abnormal_behavioral_response1.26028118
54MP0004147_increased_porphyrin_level1.25467633
55MP0003880_abnormal_central_pattern1.23626895
56MP0002064_seizures1.23435141
57MP0002877_abnormal_melanocyte_morpholog1.21423841
58MP0001968_abnormal_touch/_nociception1.19270338
59MP0000427_abnormal_hair_cycle1.19047477
60MP0002909_abnormal_adrenal_gland1.17759725
61MP0003953_abnormal_hormone_level1.16227676
62MP0003283_abnormal_digestive_organ1.15659756
63MP0000604_amyloidosis1.14082361
64MP0002009_preneoplasia1.11624864
65MP0008057_abnormal_DNA_replication1.09506427
66MP0001873_stomach_inflammation1.06959353
67MP0008872_abnormal_physiological_respon1.06052110
68MP0000579_abnormal_nail_morphology1.05636894
69MP0001756_abnormal_urination1.05220834
70MP0005408_hypopigmentation1.04262754
71MP0003011_delayed_dark_adaptation1.03495592
72MP0000003_abnormal_adipose_tissue1.02931883
73MP0005360_urolithiasis1.02538837
74MP0005423_abnormal_somatic_nervous1.02024884
75MP0005448_abnormal_energy_balance1.01581435
76MP0005535_abnormal_body_temperature1.01355994
77MP0003172_abnormal_lysosome_physiology0.98571874
78MP0002118_abnormal_lipid_homeostasis0.97184731
79MP0002735_abnormal_chemical_nociception0.95867262
80MP0009840_abnormal_foam_cell0.95421018
81MP0002557_abnormal_social/conspecific_i0.94796240
82MP0001970_abnormal_pain_threshold0.93317901
83MP0003950_abnormal_plasma_membrane0.92552686
84MP0010678_abnormal_skin_adnexa0.92161000
85MP0002160_abnormal_reproductive_system0.92093717
86MP0003122_maternal_imprinting0.91613143
87MP0003252_abnormal_bile_duct0.90827292
88MP0006036_abnormal_mitochondrial_physio0.89977475
89MP0002090_abnormal_vision0.89779100
90MP0005257_abnormal_intraocular_pressure0.89071556
91MP0004782_abnormal_surfactant_physiolog0.89015607
92MP0003195_calcinosis0.87512250
93MP0001919_abnormal_reproductive_system0.86542838
94MP0005451_abnormal_body_composition0.84996363
95MP0002572_abnormal_emotion/affect_behav0.84393323
96MP0000490_abnormal_crypts_of0.84351404
97MP0005195_abnormal_posterior_eye0.83638114
98MP0001664_abnormal_digestion0.83530116
99MP0001346_abnormal_lacrimal_gland0.83219059
100MP0005395_other_phenotype0.81745630
101MP0000538_abnormal_urinary_bladder0.80809510
102MP0003300_gastrointestinal_ulcer0.79925021
103MP0002733_abnormal_thermal_nociception0.79469094
104MP0003303_peritoneal_inflammation0.79343255
105MP0000383_abnormal_hair_follicle0.78694393
106MP0001502_abnormal_circadian_rhythm0.78585341
107MP0001984_abnormal_olfaction0.78421618
108MP0002796_impaired_skin_barrier0.77358615
109MP0002928_abnormal_bile_duct0.76442953
110MP0000920_abnormal_myelination0.76278634
111MP0004924_abnormal_behavior0.75835033
112MP0005386_behavior/neurological_phenoty0.75835033
113MP0003635_abnormal_synaptic_transmissio0.75640160
114MP0003453_abnormal_keratinocyte_physiol0.75168531
115MP0008875_abnormal_xenobiotic_pharmacok0.75099381
116MP0001666_abnormal_nutrient_absorption0.75090247
117MP0001764_abnormal_homeostasis0.74897007
118MP0005381_digestive/alimentary_phenotyp0.74232066
119MP0000631_abnormal_neuroendocrine_gland0.73481235
120MP0001765_abnormal_ion_homeostasis0.73178408
121MP0002063_abnormal_learning/memory/cond0.72432876
122MP0008004_abnormal_stomach_pH0.71758486
123MP0005389_reproductive_system_phenotype0.71286082
124MP0008961_abnormal_basal_metabolism0.71149122
125MP0004885_abnormal_endolymph0.70743081
126MP0000477_abnormal_intestine_morphology0.70511046
127MP0000372_irregular_coat_pigmentation0.69812018
128MP0004947_skin_inflammation0.67180905
129MP0003959_abnormal_lean_body0.67152087
130MP0000358_abnormal_cell_content/0.66749536
131MP0001485_abnormal_pinna_reflex0.66393623
132MP0003315_abnormal_perineum_morphology0.66325940
133MP0000470_abnormal_stomach_morphology0.65400058
134MP0001324_abnormal_eye_pigmentation0.64528202
135MP0003634_abnormal_glial_cell0.63473814
136MP0002751_abnormal_autonomic_nervous0.63308478
137MP0003045_fibrosis0.60765143
138MP0002752_abnormal_somatic_nervous0.60131755
139MP0009643_abnormal_urine_homeostasis0.59983976
140MP0002736_abnormal_nociception_after0.59480096
141MP0008877_abnormal_DNA_methylation0.58311547
142MP0004957_abnormal_blastocyst_morpholog0.55804128
143MP0000627_abnormal_mammary_gland0.53097842
144MP0008932_abnormal_embryonic_tissue0.51886010
145MP0005391_vision/eye_phenotype0.50222510
146MP0003186_abnormal_redox_activity0.50165241
147MP0002098_abnormal_vibrissa_morphology0.50112660
148MP0003136_yellow_coat_color0.49788310
149MP0002638_abnormal_pupillary_reflex0.48446060
150MP0001663_abnormal_digestive_system0.47622052
151MP0003632_abnormal_nervous_system0.44892019
152MP0005621_abnormal_cell_physiology0.43816403
153MP0004019_abnormal_vitamin_homeostasis0.43589295
154MP0005377_hearing/vestibular/ear_phenot0.42644756
155MP0003878_abnormal_ear_physiology0.42644756
156MP0002006_tumorigenesis0.41898398
157MP0003879_abnormal_hair_cell0.41575804
158MP0004858_abnormal_nervous_system0.41469659
159MP0005384_cellular_phenotype0.41138585
160MP0003786_premature_aging0.39858043
161MP0002419_abnormal_innate_immunity0.39061695
162MP0002882_abnormal_neuron_morphology0.38882016
163MP0008789_abnormal_olfactory_epithelium0.37840409

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)8.96383663
2Abnormality of glycolipid metabolism (HP:0010969)8.96383663
3Abnormality of liposaccharide metabolism (HP:0010968)8.96383663
4J-shaped sella turcica (HP:0002680)7.79816880
5Carpal bone hypoplasia (HP:0001498)7.70716255
6Thoracolumbar scoliosis (HP:0002944)7.33459161
7Vertebral arch anomaly (HP:0008438)6.51789086
8Diastasis recti (HP:0001540)5.70183154
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)5.55733723
10Flat acetabular roof (HP:0003180)5.50502082
11Dysostosis multiplex (HP:0000943)5.46543080
12Mucopolysacchariduria (HP:0008155)5.13590802
13Urinary glycosaminoglycan excretion (HP:0003541)5.13590802
14Abnormality of the lumbar spine (HP:0100712)5.06568677
15Hypoglycemic coma (HP:0001325)4.97850747
16Abnormality of mucopolysaccharide metabolism (HP:0011020)4.86212724
17Abnormality of polysaccharide metabolism (HP:0011012)4.86212724
18Abnormality of glycosaminoglycan metabolism (HP:0004371)4.86212724
19Broad alveolar ridges (HP:0000187)4.85669188
20Flared iliac wings (HP:0002869)4.79098207
21Hypoglycemic seizures (HP:0002173)4.65009030
22Hyperinsulinemic hypoglycemia (HP:0000825)4.43890861
23Ketoacidosis (HP:0001993)4.30621868
24Beaking of vertebral bodies (HP:0004568)4.24242755
25Protuberant abdomen (HP:0001538)4.08464250
26Hyperactive renin-angiotensin system (HP:0000841)3.95809212
27Thoracic kyphosis (HP:0002942)3.95772349
28Deformed sella turcica (HP:0002681)3.91238113
29Decreased circulating renin level (HP:0003351)3.90545705
30Abnormality of renin-angiotensin system (HP:0000847)3.73737726
31Increased circulating renin level (HP:0000848)3.58478489
32Hyperglycemia (HP:0003074)3.55709372
33Abnormality of aromatic amino acid family metabolism (HP:0004338)3.52871211
34Thickened calvaria (HP:0002684)3.51276007
35Hypoplasia of the odontoid process (HP:0003311)3.47929975
36Symptomatic seizures (HP:0011145)3.45063215
37Broad ribs (HP:0000885)3.17345903
38Hyperphosphatemia (HP:0002905)3.08089061
39Ketosis (HP:0001946)3.02327297
40Late onset (HP:0003584)2.98706598
41Aortic regurgitation (HP:0001659)2.97708914
42Abnormality of vitamin B metabolism (HP:0004340)2.94347945
43Aplasia/Hypoplasia of the scapulae (HP:0006713)2.93380907
44Hypoplastic scapulae (HP:0000882)2.93380907
45Dyschromatopsia (HP:0007641)2.90696003
46Abnormality of the sella turcica (HP:0002679)2.88493357
47Abnormality of the odontoid process (HP:0003310)2.82457913
48Abnormality of the pancreatic islet cells (HP:0006476)2.80010249
49Abnormality of endocrine pancreas physiology (HP:0012093)2.80010249
50Abdominal distention (HP:0003270)2.75864222
51Proximal tubulopathy (HP:0000114)2.70001735
52Pathologic fracture (HP:0002756)2.68614074
53Abnormality of vitamin metabolism (HP:0100508)2.67176626
54Corneal erosion (HP:0200020)2.61655903
55Insulin-resistant diabetes mellitus (HP:0000831)2.61364200
56Testicular neoplasm (HP:0010788)2.60185285
57Abnormal pancreas size (HP:0012094)2.59695496
58Hoarse voice (HP:0001609)2.57913098
59Epileptiform EEG discharges (HP:0011182)2.54266498
60Hypokinesia (HP:0002375)2.54258960
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54236894
62Recurrent bronchitis (HP:0002837)2.54216348
63EEG with generalized epileptiform discharges (HP:0011198)2.53312313
64Abnormality of the alveolar ridges (HP:0006477)2.51785714
65Hyperaldosteronism (HP:0000859)2.51587253
66Double outlet right ventricle (HP:0001719)2.50259945
67Congenital malformation of the right heart (HP:0011723)2.50259945
68Vacuolated lymphocytes (HP:0001922)2.48404968
69Neurofibrillary tangles (HP:0002185)2.47937656
70Metabolic alkalosis (HP:0200114)2.47761181
71Abnormality of the thoracic spine (HP:0100711)2.45597404
72Right ventricular cardiomyopathy (HP:0011663)2.42603113
73Glycosuria (HP:0003076)2.41193127
74Abnormality of urine glucose concentration (HP:0011016)2.41193127
75Fat malabsorption (HP:0002630)2.38275777
76Ovoid vertebral bodies (HP:0003300)2.37029864
77Hypsarrhythmia (HP:0002521)2.36734111
78Hypothermia (HP:0002045)2.36267964
79Enlarged penis (HP:0000040)2.35070685
80Hyperkalemia (HP:0002153)2.31287083
81Submucous cleft hard palate (HP:0000176)2.26971324
82Conjunctival hamartoma (HP:0100780)2.24330570
83Palpebral edema (HP:0100540)2.21525235
84Gout (HP:0001997)2.19463996
85Large for gestational age (HP:0001520)2.19385818
86Alkalosis (HP:0001948)2.19195437
87Villous atrophy (HP:0011473)2.17793172
88Abnormality of small intestinal villus morphology (HP:0011472)2.17793172
89Diminished movement (HP:0002374)2.17023594
90Recurrent pneumonia (HP:0006532)2.15048233
91Hypobetalipoproteinemia (HP:0003563)2.13842555
92Hyperthyroidism (HP:0000836)2.12154658
93Abnormality of chloride homeostasis (HP:0011422)2.11947665
94Cavernous hemangioma (HP:0001048)2.11016765
95Anxiety (HP:0000739)2.09575226
96Abnormality of the vitamin B12 metabolism (HP:0004341)2.09083148
97Breast carcinoma (HP:0003002)2.08854558
98Palpitations (HP:0001962)2.08255453
99Acne (HP:0001061)2.07649269
100Vascular calcification (HP:0004934)2.07538000
101Intention tremor (HP:0002080)2.07233436
102Septate vagina (HP:0001153)2.07048841
103Abnormality of potassium homeostasis (HP:0011042)2.03071468
104Hamartoma of the eye (HP:0010568)2.02750407
105Gaze-evoked nystagmus (HP:0000640)2.02427771
106Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00737149
107Dysautonomia (HP:0002459)2.00259847
108Testicular atrophy (HP:0000029)1.99508019
109Intrahepatic cholestasis (HP:0001406)1.98369616
110Congenital stationary night blindness (HP:0007642)1.97110166
111Hypokalemia (HP:0002900)1.96246532
112Hypotension (HP:0002615)1.95779149
113Lack of skin elasticity (HP:0100679)1.95173599
114Muscular hypotonia of the trunk (HP:0008936)1.94756398
115Sensory axonal neuropathy (HP:0003390)1.94654216
116Tongue fasciculations (HP:0001308)1.93758735
117Hyperphosphaturia (HP:0003109)1.93588753
118Posterior subcapsular cataract (HP:0007787)1.93503436
119Death in childhood (HP:0003819)1.92889629
120Wide intermamillary distance (HP:0006610)1.92886069
121Abnormal biliary tract morphology (HP:0012440)1.92863476
122Postural tremor (HP:0002174)1.92699220
123Hyponatremia (HP:0002902)1.89867017
124Pheochromocytoma (HP:0002666)1.89660587
125Megaloblastic anemia (HP:0001889)1.89507105
126Craniofacial hyperostosis (HP:0004493)1.88944678
127Adrenal overactivity (HP:0002717)1.87730357
128Steatorrhea (HP:0002570)1.86293293
129Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84026529
130Macroorchidism (HP:0000053)1.83449694
131Cardiomegaly (HP:0001640)1.82711729
132Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.82187668
133Metabolic acidosis (HP:0001942)1.80921668
134Segmental peripheral demyelination/remyelination (HP:0003481)1.80489792
135Hepatic necrosis (HP:0002605)1.79567835
136Amelogenesis imperfecta (HP:0000705)1.78653294
137Neuroendocrine neoplasm (HP:0100634)1.78027320
138Congenital ichthyosiform erythroderma (HP:0007431)1.77735780
139Unilateral renal agenesis (HP:0000122)1.77627817
140Agitation (HP:0000713)1.76320728
141Decreased central vision (HP:0007663)1.75930902
142Abnormality of macrophages (HP:0004311)1.75692960
143Choroideremia (HP:0001139)1.75436470
144Confusion (HP:0001289)1.75209057
145Abnormality of the renal cortex (HP:0011035)1.75171129
146Goiter (HP:0000853)1.75035834
147Neoplasm of the adrenal gland (HP:0100631)1.74663328
148Abnormality of renal excretion (HP:0011036)1.73221024
149Hydroxyprolinuria (HP:0003080)1.72015913
150Abnormality of proline metabolism (HP:0010907)1.72015913
151Abnormality of magnesium homeostasis (HP:0004921)1.71592866
152Growth hormone excess (HP:0000845)1.70658016
153Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70349713
154Renal cortical cysts (HP:0000803)1.70284314
155Menstrual irregularities (HP:0000858)1.70232682
156Abnormality of macular pigmentation (HP:0008002)1.70101022
157Urethral obstruction (HP:0000796)1.68925519
158Abnormality of the humerus (HP:0003063)1.68460669
159Cerebral hypomyelination (HP:0006808)1.68334681
160Bronchitis (HP:0012387)1.67109603
161Abnormality of the wing of the ilium (HP:0011867)1.64488896
162Aplasia/Hypoplasia of the fovea (HP:0008060)1.63719947
163Hypoplasia of the fovea (HP:0007750)1.63719947
164Malnutrition (HP:0004395)1.62758263
165Abnormality of the upper arm (HP:0001454)1.61866670
166Megalocornea (HP:0000485)1.60733348
167Progressive muscle weakness (HP:0003323)1.60667615
168Abnormal autonomic nervous system physiology (HP:0012332)1.60393424
169Keratoconus (HP:0000563)1.59444628
170Increased corneal curvature (HP:0100692)1.59444628
171Cerebral inclusion bodies (HP:0100314)1.58653144
172Pili torti (HP:0003777)1.57038753
173Severe global developmental delay (HP:0011344)1.56577781
174Corneal dystrophy (HP:0001131)1.55753525
175Supranuclear gaze palsy (HP:0000605)1.55224564
176Hyperparathyroidism (HP:0000843)1.55208398
177Chin dimple (HP:0010751)1.54273777
178Increased cerebral lipofuscin (HP:0011813)1.52379154
179Cranial hyperostosis (HP:0004437)1.49303259
180Hypomagnesemia (HP:0002917)1.45215548
181Parakeratosis (HP:0001036)1.45013285
182External ophthalmoplegia (HP:0000544)1.44574226
183Abnormality of the fovea (HP:0000493)1.44521366
184Increased neuronal autofluorescent lipopigment (HP:0002074)1.43495895
185Abnormality of calcium-phosphate metabolism (HP:0100530)1.43415208
186Progressive neurologic deterioration (HP:0002344)1.42768659
187Overlapping toe (HP:0001845)1.42533033
188Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.41736669
189Stenosis of the external auditory canal (HP:0000402)1.39597913
190Split hand (HP:0001171)1.39572414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.37517935
2NTRK14.04577104
3NME23.48727611
4PBK3.45347442
5IRAK33.34835669
6MAPKAPK33.05949884
7ARAF2.83307290
8MST42.74267326
9STK392.65040428
10DAPK22.51810734
11AKT32.38480157
12KSR22.38131937
13MAP3K22.34071153
14NTRK32.19245532
15ACVR1B2.16898721
16OXSR12.16866013
17MAP3K92.13148102
18PHKG22.10537040
19PHKG12.10537040
20FGFR22.03953316
21MAP3K121.96702390
22TAOK31.94434848
23MAP2K61.86281582
24EIF2AK11.83990913
25TRIM281.79394366
26MAPK151.72427031
27LATS21.67560162
28STK241.62618392
29PLK41.62421697
30STK38L1.62008934
31BRAF1.59923222
32LMTK21.58205233
33FRK1.56944771
34MET1.54557602
35ERN11.45349307
36MAP2K21.39961183
37NLK1.28189987
38RET1.27536092
39IRAK41.26528117
40HIPK21.23469330
41MAPKAPK51.23095730
42FGFR31.23040391
43WNK41.22904919
44DAPK11.22453060
45EPHB11.20692789
46BUB11.20666376
47CASK1.20467302
48PAK31.15870105
49BLK1.12374313
50PRKCI1.08682008
51BMPR1B1.07551451
52BCR1.06264173
53PASK1.03428666
54LATS11.03387757
55MATK1.02539421
56BRSK21.01328540
57NEK61.00039143
58TTK0.99359532
59TNK20.98110045
60FER0.97621500
61CDK120.96727966
62EIF2AK30.93633103
63INSRR0.92909649
64PIK3CA0.87578934
65GRK50.86968579
66MAP3K10.86224900
67MARK30.85247698
68IRAK20.84700585
69MAP4K10.83591219
70RIPK40.81917634
71MAP3K130.80954111
72NME10.79642483
73RPS6KB20.78920985
74ERBB30.78319000
75EPHB20.77561255
76UHMK10.77195491
77FGR0.75697317
78MST1R0.74742809
79TRPM70.73631734
80TESK20.73113786
81LIMK10.72585068
82PRKD30.71121887
83TSSK60.70227327
84ERBB40.70136176
85PRKAA10.68144867
86EEF2K0.68128837
87MINK10.67807001
88PRKAA20.66208267
89WNK30.64872935
90GRK10.64785293
91BMPR20.63675738
92ABL20.62186265
93PAK60.60346058
94PRKD20.60047558
95IKBKB0.59182081
96CAMK1G0.58951062
97MAPK110.58429047
98AURKA0.58272411
99PDK10.57256236
100CSNK1G30.56576385
101DYRK20.56418402
102PTK20.55531788
103IRAK10.55287629
104MAP3K40.55079979
105CSNK1G10.54961975
106SCYL20.54139145
107MAP4K20.53034702
108PRKCE0.52444275
109RPS6KB10.51171931
110PRKCG0.49017880
111PNCK0.48005348
112CSNK1A10.47998743
113TAOK10.47864925
114CDK30.47440437
115MAP2K10.47035560
116CHEK20.46513310
117MOS0.46476261
118ADRBK20.46377115
119BRSK10.45323012
120STK110.45313501
121CSNK1E0.44320466
122PRKCZ0.44116859
123PRKCD0.43387535
124* CAMK2D0.42668599
125STK100.42628237
126SGK10.41428991
127AKT20.40339308
128SGK20.40050198
129MAP3K30.39306618
130CAMK2G0.38937178
131PRKG20.38777593
132CAMK2B0.38608785
133CSNK1A1L0.38583846
134EPHA40.38284759
135TESK10.38166390
136PINK10.37444854
137CDK50.35649582
138CAMKK20.35644975
139PDPK10.34301134
140EPHA30.34052002
141CAMK2A0.33876361
142YES10.33407034
143PAK10.32529230
144MAP3K80.31985837
145PRKCA0.31362283
146NUAK10.31312617
147PLK30.30583277
148STK30.30219322
149SGK2230.29890819
150SGK4940.29890819
151CDK140.29122719
152MAPKAPK20.28881633
153STK380.28657824
154CAMK1D0.27651075
155ABL10.27008491
156ALK0.21906666

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.83823401
2Lysosome_Homo sapiens_hsa041423.03369886
3Other glycan degradation_Homo sapiens_hsa005112.91011244
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.84992607
5Protein export_Homo sapiens_hsa030602.72119479
6Collecting duct acid secretion_Homo sapiens_hsa049662.66048595
7Regulation of autophagy_Homo sapiens_hsa041402.60683287
8Ether lipid metabolism_Homo sapiens_hsa005652.32647261
9Vibrio cholerae infection_Homo sapiens_hsa051102.30729109
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21565671
11Sulfur metabolism_Homo sapiens_hsa009202.16903972
12Synaptic vesicle cycle_Homo sapiens_hsa047212.16869750
13Butanoate metabolism_Homo sapiens_hsa006502.10662087
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.10151089
15Mineral absorption_Homo sapiens_hsa049782.04544516
16Sphingolipid metabolism_Homo sapiens_hsa006002.03484388
17Phototransduction_Homo sapiens_hsa047441.91526920
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90039225
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.76820791
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76166444
21Arginine biosynthesis_Homo sapiens_hsa002201.73061568
22Linoleic acid metabolism_Homo sapiens_hsa005911.72303040
23Steroid biosynthesis_Homo sapiens_hsa001001.69616844
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66137322
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61808168
26Caffeine metabolism_Homo sapiens_hsa002321.61562309
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60434712
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59472450
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56277067
30Pancreatic secretion_Homo sapiens_hsa049721.49031257
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38961810
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38192905
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.37459867
34Rheumatoid arthritis_Homo sapiens_hsa053231.35581820
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32939919
36Type I diabetes mellitus_Homo sapiens_hsa049401.30580919
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30503642
38Amphetamine addiction_Homo sapiens_hsa050311.30200830
39Renin secretion_Homo sapiens_hsa049241.27086579
40Phagosome_Homo sapiens_hsa041451.24704541
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24300182
42Folate biosynthesis_Homo sapiens_hsa007901.23817753
43Tryptophan metabolism_Homo sapiens_hsa003801.23815499
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22203949
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.20754720
46Circadian rhythm_Homo sapiens_hsa047101.20189494
47Peroxisome_Homo sapiens_hsa041461.18664781
48RNA polymerase_Homo sapiens_hsa030201.17796476
49Bile secretion_Homo sapiens_hsa049761.10948367
50Fructose and mannose metabolism_Homo sapiens_hsa000511.10901872
51Arachidonic acid metabolism_Homo sapiens_hsa005901.05920348
52Renin-angiotensin system_Homo sapiens_hsa046141.05469331
53Insulin secretion_Homo sapiens_hsa049111.05271842
54Fatty acid elongation_Homo sapiens_hsa000621.04855861
55Glucagon signaling pathway_Homo sapiens_hsa049221.02537224
56Serotonergic synapse_Homo sapiens_hsa047261.02224131
57Taste transduction_Homo sapiens_hsa047421.01005662
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99018505
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98979898
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98433745
61Fatty acid degradation_Homo sapiens_hsa000710.96884368
62Vitamin B6 metabolism_Homo sapiens_hsa007500.96434053
63Endocytosis_Homo sapiens_hsa041440.96327349
64Fatty acid metabolism_Homo sapiens_hsa012120.95912834
65Tight junction_Homo sapiens_hsa045300.95629336
66Dopaminergic synapse_Homo sapiens_hsa047280.95601268
67Inositol phosphate metabolism_Homo sapiens_hsa005620.95526043
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94802369
69Propanoate metabolism_Homo sapiens_hsa006400.94509250
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93341461
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92194658
72Fatty acid biosynthesis_Homo sapiens_hsa000610.92072532
73Proteasome_Homo sapiens_hsa030500.91641343
74Starch and sucrose metabolism_Homo sapiens_hsa005000.91304254
75beta-Alanine metabolism_Homo sapiens_hsa004100.90983162
76Selenocompound metabolism_Homo sapiens_hsa004500.90413633
77Retinol metabolism_Homo sapiens_hsa008300.89690433
78ABC transporters_Homo sapiens_hsa020100.88077537
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86144418
80Thyroid cancer_Homo sapiens_hsa052160.85086105
81Basal transcription factors_Homo sapiens_hsa030220.85051710
82Homologous recombination_Homo sapiens_hsa034400.83027729
83Nitrogen metabolism_Homo sapiens_hsa009100.81499186
84Galactose metabolism_Homo sapiens_hsa000520.81470959
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79900620
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.77027534
87Fat digestion and absorption_Homo sapiens_hsa049750.76234110
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75810412
89Renal cell carcinoma_Homo sapiens_hsa052110.74978874
90Chemical carcinogenesis_Homo sapiens_hsa052040.74728676
91Salivary secretion_Homo sapiens_hsa049700.74496259
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.74071727
93Nicotine addiction_Homo sapiens_hsa050330.70999067
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69944684
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68942266
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68245189
97Circadian entrainment_Homo sapiens_hsa047130.68206710
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65980901
99Salmonella infection_Homo sapiens_hsa051320.65803650
100Oxidative phosphorylation_Homo sapiens_hsa001900.65188670
101Dorso-ventral axis formation_Homo sapiens_hsa043200.63501389
102Long-term potentiation_Homo sapiens_hsa047200.63268928
103Tuberculosis_Homo sapiens_hsa051520.62986546
104Protein digestion and absorption_Homo sapiens_hsa049740.62540925
105GABAergic synapse_Homo sapiens_hsa047270.62034824
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.59759262
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57831980
108Cholinergic synapse_Homo sapiens_hsa047250.57427350
109Glutamatergic synapse_Homo sapiens_hsa047240.56130278
110Gastric acid secretion_Homo sapiens_hsa049710.55665451
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53622702
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52345217
113Metabolic pathways_Homo sapiens_hsa011000.52098506
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.50713709
115Shigellosis_Homo sapiens_hsa051310.47714739
116Ovarian steroidogenesis_Homo sapiens_hsa049130.47705813
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.46675335
118Cocaine addiction_Homo sapiens_hsa050300.46155740
119N-Glycan biosynthesis_Homo sapiens_hsa005100.45102953
120Prostate cancer_Homo sapiens_hsa052150.44671501
121Vitamin digestion and absorption_Homo sapiens_hsa049770.44341573
122Pentose phosphate pathway_Homo sapiens_hsa000300.44128877
123Non-homologous end-joining_Homo sapiens_hsa034500.44061148
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44023272
125Glutathione metabolism_Homo sapiens_hsa004800.42067310
126Insulin resistance_Homo sapiens_hsa049310.41580798
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41341806
128Glycerolipid metabolism_Homo sapiens_hsa005610.41189524
129mTOR signaling pathway_Homo sapiens_hsa041500.40746886
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40015713
131Oocyte meiosis_Homo sapiens_hsa041140.39368857
132Arginine and proline metabolism_Homo sapiens_hsa003300.38940979
133Prolactin signaling pathway_Homo sapiens_hsa049170.38105451
134Bladder cancer_Homo sapiens_hsa052190.37745971
135Histidine metabolism_Homo sapiens_hsa003400.37168404
136Phenylalanine metabolism_Homo sapiens_hsa003600.36777547
137Choline metabolism in cancer_Homo sapiens_hsa052310.36525899
138Hepatitis C_Homo sapiens_hsa051600.36041165
139AMPK signaling pathway_Homo sapiens_hsa041520.35831601
140Ras signaling pathway_Homo sapiens_hsa040140.35241419
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.34334490
142Cell cycle_Homo sapiens_hsa041100.32277417
143Adherens junction_Homo sapiens_hsa045200.32264024
144Legionellosis_Homo sapiens_hsa051340.32227991
145Epstein-Barr virus infection_Homo sapiens_hsa051690.31593974
146Type II diabetes mellitus_Homo sapiens_hsa049300.31371501
147Thyroid hormone synthesis_Homo sapiens_hsa049180.31356632
148Pertussis_Homo sapiens_hsa051330.29402617
149Pancreatic cancer_Homo sapiens_hsa052120.29175106
150Hematopoietic cell lineage_Homo sapiens_hsa046400.29049575
151Long-term depression_Homo sapiens_hsa047300.28942954
152GnRH signaling pathway_Homo sapiens_hsa049120.27173569
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26776663
154Purine metabolism_Homo sapiens_hsa002300.26330868

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