TPCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.13744552
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.13744552
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.13744552
4modulation by symbiont of host immune response (GO:0052553)6.13744552
5positive regulation by symbiont of host defense response (GO:0052509)6.13744552
6modulation by symbiont of host defense response (GO:0052031)6.13744552
7melanin biosynthetic process (GO:0042438)5.72215150
8melanin metabolic process (GO:0006582)5.53189093
9regulation of interferon-beta biosynthetic process (GO:0045357)5.09882587
10secondary metabolite biosynthetic process (GO:0044550)5.06903874
11positive regulation of gamma-delta T cell activation (GO:0046645)4.92475663
12neutrophil activation involved in immune response (GO:0002283)4.70620211
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60753824
14macrophage activation involved in immune response (GO:0002281)4.58286866
15regulation of B cell receptor signaling pathway (GO:0050855)4.14902685
16neutrophil mediated immunity (GO:0002446)4.12389977
17pigment cell differentiation (GO:0050931)4.08590866
18melanocyte differentiation (GO:0030318)4.08504951
19natural killer cell mediated cytotoxicity (GO:0042267)4.06720393
20natural killer cell mediated immunity (GO:0002228)4.06720393
21immunoglobulin mediated immune response (GO:0016064)4.00253496
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.97578671
23negative regulation of cell killing (GO:0031342)3.97578671
24positive regulation of interferon-alpha production (GO:0032727)3.97442002
25response to muramyl dipeptide (GO:0032495)3.91272881
26response to host immune response (GO:0052572)3.90775524
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.90775524
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.84170591
29pinocytosis (GO:0006907)3.80809252
30response to peptidoglycan (GO:0032494)3.79211136
31regulation of interferon-alpha production (GO:0032647)3.75951826
32apoptotic cell clearance (GO:0043277)3.75849140
33positive regulation of B cell differentiation (GO:0045579)3.72517503
34cellular extravasation (GO:0045123)3.68962969
35response to host (GO:0075136)3.65899665
36response to host defenses (GO:0052200)3.65899665
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65899665
38mannose metabolic process (GO:0006013)3.56377272
39cellular response to ethanol (GO:0071361)3.53614584
40regulation of gamma-delta T cell activation (GO:0046643)3.48837677
41positive regulation of antigen processing and presentation (GO:0002579)3.47271040
42indole-containing compound catabolic process (GO:0042436)3.44206392
43indolalkylamine catabolic process (GO:0046218)3.44206392
44tryptophan catabolic process (GO:0006569)3.44206392
45microglial cell activation (GO:0001774)3.43644045
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.42859742
47myeloid cell activation involved in immune response (GO:0002275)3.40700742
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38996068
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38996068
50regulation of gamma-delta T cell differentiation (GO:0045586)3.36977354
51germinal center formation (GO:0002467)3.27236981
52neutrophil activation (GO:0042119)3.25749212
53I-kappaB phosphorylation (GO:0007252)3.24433983
54negative regulation of calcium ion transport into cytosol (GO:0010523)3.22584153
55negative regulation of granulocyte differentiation (GO:0030853)3.21997542
56regulation of integrin activation (GO:0033623)3.19062075
57regulation of cholesterol storage (GO:0010885)3.18265359
58granulocyte activation (GO:0036230)3.18147746
59antigen processing and presentation of endogenous antigen (GO:0019883)3.15923058
60positive thymic T cell selection (GO:0045059)3.12084487
61respiratory burst (GO:0045730)3.07994006
62myeloid leukocyte mediated immunity (GO:0002444)3.07592542
63indolalkylamine metabolic process (GO:0006586)3.06249121
64cell adhesion mediated by integrin (GO:0033627)3.05914747
65NAD biosynthetic process (GO:0009435)3.05027501
66macrophage activation (GO:0042116)3.03806849
67negative regulation of interleukin-12 production (GO:0032695)3.02979570
68opioid receptor signaling pathway (GO:0038003)3.02434996
69negative regulation of mast cell activation (GO:0033004)3.02383042
70B cell receptor signaling pathway (GO:0050853)2.99926204
71positive regulation of cellular amide metabolic process (GO:0034250)2.99816796
72positive regulation of interferon-beta production (GO:0032728)2.99390500
73NIK/NF-kappaB signaling (GO:0038061)2.95482261
74regulation of interleukin-12 biosynthetic process (GO:0045075)2.93403748
75positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91569549
76wound healing, spreading of epidermal cells (GO:0035313)2.91216982
77modulation by symbiont of host cellular process (GO:0044068)2.89271145
78B cell mediated immunity (GO:0019724)2.88754970
79negative regulation of interleukin-1 production (GO:0032692)2.88347142
80regulation of antigen processing and presentation (GO:0002577)2.88207977
81regulation of B cell differentiation (GO:0045577)2.85557794
82N-acetylneuraminate metabolic process (GO:0006054)2.85076788
83defense response to protozoan (GO:0042832)2.84821299
84low-density lipoprotein particle clearance (GO:0034383)2.84612246
85pigment granule organization (GO:0048753)2.83204575
86leukocyte mediated cytotoxicity (GO:0001909)2.82340422
87regulation of mast cell degranulation (GO:0043304)2.81608918
88leukocyte migration involved in inflammatory response (GO:0002523)2.81024086
89positive regulation of p38MAPK cascade (GO:1900745)2.80966839
90melanosome organization (GO:0032438)2.80314199
91negative regulation of interleukin-6 production (GO:0032715)2.79893199
92detection of molecule of bacterial origin (GO:0032490)2.79634813
93tryptophan metabolic process (GO:0006568)2.79100663
94regulation of interleukin-8 biosynthetic process (GO:0045414)2.78363103
95B cell homeostasis (GO:0001782)2.76586484
96lipoprotein transport (GO:0042953)2.74948757
97response to laminar fluid shear stress (GO:0034616)2.74634797
98leukocyte aggregation (GO:0070486)2.72097593
99negative regulation of lipid storage (GO:0010888)2.70002007
100antigen processing and presentation via MHC class Ib (GO:0002475)2.67856865
101positive regulation of defense response to virus by host (GO:0002230)2.66061766
102positive regulation of mast cell activation (GO:0033005)2.65773782
103regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.65700317
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65473920
105regulation of mast cell activation involved in immune response (GO:0033006)2.64893567
106kynurenine metabolic process (GO:0070189)2.64230555
107pyridine nucleotide biosynthetic process (GO:0019363)2.61951806
108nicotinamide nucleotide biosynthetic process (GO:0019359)2.61951806
109tyrosine metabolic process (GO:0006570)2.61418970
110leukocyte cell-cell adhesion (GO:0007159)2.59989961
111adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.59837015
112response to protozoan (GO:0001562)2.58377387
113positive regulation of cell adhesion mediated by integrin (GO:0033630)2.57119073
114cytokine secretion (GO:0050663)2.56617830
115lymphocyte mediated immunity (GO:0002449)2.55928260
116regulation of mast cell activation (GO:0033003)2.55584484
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55151219
118regulation of phagocytosis (GO:0050764)2.55126869
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54634316
120regulation of leukocyte degranulation (GO:0043300)2.53455266
121lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52567859
122positive regulation of T cell apoptotic process (GO:0070234)2.52178986
123positive regulation of leukocyte apoptotic process (GO:2000108)2.51914845
124cortical actin cytoskeleton organization (GO:0030866)2.51906696
125ketone body metabolic process (GO:1902224)2.51719778
126myeloid cell homeostasis (GO:0002262)2.51224315
127detection of other organism (GO:0098543)2.50751646
128negative regulation of interleukin-1 beta production (GO:0032691)2.50559157
129response to pheromone (GO:0019236)2.50473264
130positive regulation of phagocytosis (GO:0050766)2.50319545
131neuroepithelial cell differentiation (GO:0060563)2.50234981
132proline transport (GO:0015824)2.49166855
133endosome to pigment granule transport (GO:0043485)2.48584002
134endosome to melanosome transport (GO:0035646)2.48584002
135phenol-containing compound biosynthetic process (GO:0046189)2.47635428
136fucose catabolic process (GO:0019317)2.46514230
137L-fucose metabolic process (GO:0042354)2.46514230
138L-fucose catabolic process (GO:0042355)2.46514230
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.46430365
140lysosome organization (GO:0007040)2.46129469
141lytic vacuole organization (GO:0080171)2.46129469
142cellular response to ATP (GO:0071318)2.40841968
143detection of external biotic stimulus (GO:0098581)2.39822988
144regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.38480391
145negative regulation of T cell mediated immunity (GO:0002710)2.38154616
146negative regulation of cAMP-mediated signaling (GO:0043951)2.36487382
147detection of bacterium (GO:0016045)2.36382509
148cellular response to exogenous dsRNA (GO:0071360)2.35160390
149regulation of MHC class II biosynthetic process (GO:0045346)2.32927340
150amino sugar catabolic process (GO:0046348)2.31522366
151amine catabolic process (GO:0009310)2.30736300
152cellular biogenic amine catabolic process (GO:0042402)2.30736300
153activated T cell proliferation (GO:0050798)2.30348913
154piRNA metabolic process (GO:0034587)2.27945296
155superoxide anion generation (GO:0042554)2.27775648
156hydrogen peroxide biosynthetic process (GO:0050665)2.26633497
157response to type I interferon (GO:0034340)2.26324904
158reactive oxygen species biosynthetic process (GO:1903409)2.25637781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.53241581
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.45997601
3* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66998856
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.45688468
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.43862636
6E2F7_22180533_ChIP-Seq_HELA_Human3.43674643
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22806334
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22497259
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16419735
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.13765861
11* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92910199
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.84222474
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77522177
14VDR_21846776_ChIP-Seq_THP-1_Human2.58717600
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.46250509
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.41828482
17ZNF274_21170338_ChIP-Seq_K562_Hela2.33610763
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31376463
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.30049303
20SCL_19346495_ChIP-Seq_HPC-7_Human2.23281318
21SPI1_23127762_ChIP-Seq_K562_Human2.20917785
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19323029
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13633100
24VDR_24763502_ChIP-Seq_THP-1_Human2.12423249
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09063371
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05294494
27* SPI1_23547873_ChIP-Seq_NB4_Human2.01975113
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01514926
29GBX2_23144817_ChIP-Seq_PC3_Human1.97552747
30MYC_22102868_ChIP-Seq_BL_Human1.93505278
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92101328
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91473291
33MAF_26560356_Chip-Seq_TH1_Human1.88658809
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.86687107
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81554983
36TCF7_22412390_ChIP-Seq_EML_Mouse1.80337800
37DROSHA_22980978_ChIP-Seq_HELA_Human1.78884983
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77811244
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.77086056
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.77037975
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75154191
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72490730
43MYB_26560356_Chip-Seq_TH2_Human1.71716432
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69323540
45EZH2_22144423_ChIP-Seq_EOC_Human1.65134599
46VDR_22108803_ChIP-Seq_LS180_Human1.65044450
47MYB_26560356_Chip-Seq_TH1_Human1.63751174
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61405056
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60990533
50PU_27001747_Chip-Seq_BMDM_Mouse1.60857908
51UTX_26944678_Chip-Seq_JUKART_Human1.57248601
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57120555
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51899279
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51721278
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48067510
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47862939
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47790081
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47505370
59RUNX_20019798_ChIP-Seq_JUKART_Human1.47425576
60TFEB_21752829_ChIP-Seq_HELA_Human1.46748304
61KDM2B_26808549_Chip-Seq_DND41_Human1.44239279
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39786418
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39517245
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39177495
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38006262
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38006262
67VDR_24787735_ChIP-Seq_THP-1_Human1.36146078
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35023177
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.34808772
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33844740
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32541058
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32535627
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29435017
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27865336
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26249727
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25646866
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23705375
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23219530
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22051091
80GATA1_22025678_ChIP-Seq_K562_Human1.21128037
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18967290
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18407695
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.17810195
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16617737
85IGF1R_20145208_ChIP-Seq_DFB_Human1.16569572
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.16061075
87MAF_26560356_Chip-Seq_TH2_Human1.15294932
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15174849
89STAT3_23295773_ChIP-Seq_U87_Human1.14707484
90TCF4_23295773_ChIP-Seq_U87_Human1.14224779
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13937919
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12795227
93* SMRT_27268052_Chip-Seq_Bcells_Human1.12491055
94* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12490478
95AR_21572438_ChIP-Seq_LNCaP_Human1.11888990
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11407794
97GATA3_27048872_Chip-Seq_THYMUS_Human1.11395130
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10309130
99BCAT_22108803_ChIP-Seq_LS180_Human1.09897514
100OCT4_20526341_ChIP-Seq_ESCs_Human1.09710014
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09073631
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08800857
103ER_23166858_ChIP-Seq_MCF-7_Human1.08594566
104LXR_22292898_ChIP-Seq_THP-1_Human1.08309236
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.08004204
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07599540
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06487020
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03560567
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03414161
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03225808
111NCOR1_26117541_ChIP-Seq_K562_Human1.01200668
112OCT1_27270436_Chip-Seq_PROSTATE_Human1.00875807
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00722682
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00317713
115REST_21632747_ChIP-Seq_MESCs_Mouse1.00170275
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00021871
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99436525
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98891695
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98724467
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98011885
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97999737
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96695023
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96158030
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95140471
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95026143
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95026143
127MYC_19829295_ChIP-Seq_ESCs_Human0.94772186
128RAC3_21632823_ChIP-Seq_H3396_Human0.93880343
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.93605075
130* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93185054
131TP53_16413492_ChIP-PET_HCT116_Human0.92227087
132WDR5_24793694_ChIP-Seq_LNCAP_Human0.92213542
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91936363
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.91889380
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91706958
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90366148
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89956304
138ERA_21632823_ChIP-Seq_H3396_Human0.89496109
139RACK7_27058665_Chip-Seq_MCF-7_Human0.89271842
140* GATA3_21878914_ChIP-Seq_MCF-7_Human0.89192948
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89020454
142GATA3_26560356_Chip-Seq_TH2_Human0.88569308
143GATA1_19941826_ChIP-Seq_K562_Human0.88401019
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88365104
145CLOCK_20551151_ChIP-Seq_293T_Human0.88221720
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87211963
147* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86871716
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86679163
149FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86305918
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86024517
151* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.85182447
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84794956
153CBP_20019798_ChIP-Seq_JUKART_Human0.83626978
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83626978
155* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83492349
156* AR_25329375_ChIP-Seq_VCAP_Human0.83244020
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83217507
158* BCL6_27268052_Chip-Seq_Bcells_Human0.82841599
159* CEBPB_22108803_ChIP-Seq_LS180_Human0.82453881
160SMAD_19615063_ChIP-ChIP_OVARY_Human0.82202662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.46064432
2MP0000372_irregular_coat_pigmentation4.23314172
3MP0005058_abnormal_lysosome_morphology3.80889982
4MP0003136_yellow_coat_color3.77408891
5MP0005171_absent_coat_pigmentation3.38735209
6MP0005075_abnormal_melanosome_morpholog3.07278454
7MP0001835_abnormal_antigen_presentation3.04397441
8MP0003172_abnormal_lysosome_physiology3.04060251
9MP0004381_abnormal_hair_follicle2.93799802
10MP0003303_peritoneal_inflammation2.92689134
11MP0003436_decreased_susceptibility_to2.78153823
12MP0009278_abnormal_bone_marrow2.52354522
13MP0002419_abnormal_innate_immunity2.47777472
14MP0005174_abnormal_tail_pigmentation2.41070294
15MP0002095_abnormal_skin_pigmentation2.27557058
16MP0000685_abnormal_immune_system2.25460585
17MP0005408_hypopigmentation2.23311418
18MP0006082_CNS_inflammation2.20037221
19MP0005377_hearing/vestibular/ear_phenot2.17230938
20MP0003878_abnormal_ear_physiology2.17230938
21MP0002138_abnormal_hepatobiliary_system2.17139027
22MP0003300_gastrointestinal_ulcer2.12370617
23MP0002452_abnormal_antigen_presenting2.09873596
24MP0005000_abnormal_immune_tolerance2.04927124
25MP0005464_abnormal_platelet_physiology2.04859178
26MP0001800_abnormal_humoral_immune2.04803764
27MP0003705_abnormal_hypodermis_morpholog2.01793308
28MP0009840_abnormal_foam_cell1.99730770
29MP0004947_skin_inflammation1.99643091
30MP0005387_immune_system_phenotype1.99276623
31MP0001790_abnormal_immune_system1.99276623
32MP0005025_abnormal_response_to1.98515120
33MP0003566_abnormal_cell_adhesion1.94541918
34MP0001958_emphysema1.87998318
35MP0004510_myositis1.86283761
36MP0002723_abnormal_immune_serum1.84011559
37MP0002166_altered_tumor_susceptibility1.77649673
38MP0008438_abnormal_cutaneous_collagen1.76602173
39MP0001819_abnormal_immune_cell1.74318717
40MP0003191_abnormal_cellular_cholesterol1.74142172
41MP0002420_abnormal_adaptive_immunity1.73939590
42MP0003646_muscle_fatigue1.73761974
43MP0003195_calcinosis1.72057454
44MP0009785_altered_susceptibility_to1.70348258
45MP0002405_respiratory_system_inflammati1.65990795
46MP0003183_abnormal_peptide_metabolism1.64404705
47MP0010307_abnormal_tumor_latency1.63883417
48MP0001533_abnormal_skeleton_physiology1.61626202
49MP0005310_abnormal_salivary_gland1.60584767
50MP0001853_heart_inflammation1.59982581
51MP0002396_abnormal_hematopoietic_system1.59759730
52MP0005671_abnormal_response_to1.56621977
53MP0003448_altered_tumor_morphology1.56405499
54MP0001545_abnormal_hematopoietic_system1.54923451
55MP0005397_hematopoietic_system_phenotyp1.54923451
56MP0005257_abnormal_intraocular_pressure1.54897560
57MP0000015_abnormal_ear_pigmentation1.54420086
58MP0002075_abnormal_coat/hair_pigmentati1.54250091
59MP0005076_abnormal_cell_differentiation1.45021586
60MP0002148_abnormal_hypersensitivity_rea1.44951326
61MP0001873_stomach_inflammation1.43379217
62MP0000689_abnormal_spleen_morphology1.39130299
63MP0000858_altered_metastatic_potential1.38647226
64MP0002398_abnormal_bone_marrow1.37609520
65MP0000716_abnormal_immune_system1.36017780
66MP0003279_aneurysm1.35792792
67MP0000604_amyloidosis1.34883048
68MP0003724_increased_susceptibility_to1.34867674
69MP0001501_abnormal_sleep_pattern1.33983663
70MP0001845_abnormal_inflammatory_respons1.32174700
71MP0001851_eye_inflammation1.32009785
72MP0001324_abnormal_eye_pigmentation1.31770884
73MP0002102_abnormal_ear_morphology1.31237418
74MP0002254_reproductive_system_inflammat1.30730060
75MP0002006_tumorigenesis1.30558494
76MP0000371_diluted_coat_color1.28949035
77MP0002933_joint_inflammation1.26077138
78MP0004808_abnormal_hematopoietic_stem1.24541619
79MP0002722_abnormal_immune_system1.24176510
80MP0002998_abnormal_bone_remodeling1.22299679
81MP0000465_gastrointestinal_hemorrhage1.21928895
82MP0001968_abnormal_touch/_nociception1.21915304
83MP0003690_abnormal_glial_cell1.18824401
84MP0005023_abnormal_wound_healing1.18181595
85MP0010352_gastrointestinal_tract_polyps1.17711552
86MP0000343_altered_response_to1.16417488
87MP0002429_abnormal_blood_cell1.15698758
88MP0010155_abnormal_intestine_physiology1.15458251
89MP0009333_abnormal_splenocyte_physiolog1.13706107
90MP0008469_abnormal_protein_level1.13287168
91MP0003091_abnormal_cell_migration1.11038318
92MP0000427_abnormal_hair_cycle1.01555159
93MP0005451_abnormal_body_composition1.01511733
94MP0001186_pigmentation_phenotype0.94021898
95MP0003075_altered_response_to0.93974714
96MP0005551_abnormal_eye_electrophysiolog0.93829474
97MP0005365_abnormal_bile_salt0.92928311
98MP0000490_abnormal_crypts_of0.92647879
99MP0000703_abnormal_thymus_morphology0.90972991
100MP0005167_abnormal_blood-brain_barrier0.90495634
101MP0003656_abnormal_erythrocyte_physiolo0.89595408
102MP0003453_abnormal_keratinocyte_physiol0.87699740
103MP0002736_abnormal_nociception_after0.87150718
104MP0003763_abnormal_thymus_physiology0.85167337
105MP0002837_dystrophic_cardiac_calcinosis0.83763039
106MP0004043_abnormal_pH_regulation0.83716090
107MP0001243_abnormal_dermal_layer0.81935428
108MP0008260_abnormal_autophagy0.81609816
109MP0004130_abnormal_muscle_cell0.80773562
110MP0009763_increased_sensitivity_to0.80424932
111MP0005410_abnormal_fertilization0.80103342
112MP0005390_skeleton_phenotype0.79680052
113MP0009046_muscle_twitch0.79323214
114MP0001986_abnormal_taste_sensitivity0.79257420
115MP0001915_intracranial_hemorrhage0.79256877
116MP0000767_abnormal_smooth_muscle0.79126241
117MP0002735_abnormal_chemical_nociception0.77992764
118MP0003806_abnormal_nucleotide_metabolis0.77846779
119MP0004185_abnormal_adipocyte_glucose0.77547175
120MP0005166_decreased_susceptibility_to0.77055025
121MP0002139_abnormal_hepatobiliary_system0.76898673
122MP0000733_abnormal_muscle_development0.75584764
123MP0008875_abnormal_xenobiotic_pharmacok0.75312373
124MP0005647_abnormal_sex_gland0.75104833
125MP0002168_other_aberrant_phenotype0.74963892
126MP0003828_pulmonary_edema0.74753353
127MP0009764_decreased_sensitivity_to0.74473730
128MP0010329_abnormal_lipoprotein_level0.74095892
129MP0004742_abnormal_vestibular_system0.73843812
130MP0005360_urolithiasis0.73490140
131MP0002060_abnormal_skin_morphology0.72389121
132MP0001485_abnormal_pinna_reflex0.72120576
133MP0000249_abnormal_blood_vessel0.71362727
134MP0005621_abnormal_cell_physiology0.71147584
135MP0003795_abnormal_bone_structure0.70140385
136MP0001663_abnormal_digestive_system0.69378948
137MP0005670_abnormal_white_adipose0.66587868
138MP0002229_neurodegeneration0.65584148
139MP0000470_abnormal_stomach_morphology0.64942866
140MP0003879_abnormal_hair_cell0.64648458
141MP0000230_abnormal_systemic_arterial0.64161299
142MP0000609_abnormal_liver_physiology0.64145288
143MP0003045_fibrosis0.61013131
144MP0002019_abnormal_tumor_incidence0.60451929
145MP0002733_abnormal_thermal_nociception0.57450704
146MP0002090_abnormal_vision0.56707262
147MP0003252_abnormal_bile_duct0.56262685

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.87901175
2Recurrent bacterial skin infections (HP:0005406)5.31072507
3Increased cerebral lipofuscin (HP:0011813)4.85903449
4Eczematoid dermatitis (HP:0000976)4.41421399
5Ocular albinism (HP:0001107)4.39991059
6Vacuolated lymphocytes (HP:0001922)4.05666098
7Abnormality of macrophages (HP:0004311)3.97951450
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.97087070
9Hypoplasia of the fovea (HP:0007750)3.97087070
10Iris hypopigmentation (HP:0007730)3.80164429
11Recurrent gram-negative bacterial infections (HP:0005420)3.79016920
12Abnormality of liposaccharide metabolism (HP:0010968)3.77002530
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.77002530
14Abnormality of glycolipid metabolism (HP:0010969)3.77002530
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.74861642
16Hyperventilation (HP:0002883)3.69774940
17Autoimmune thrombocytopenia (HP:0001973)3.65427962
18Aplasia/Hypoplasia of the macula (HP:0008059)3.47374638
19Blue irides (HP:0000635)3.46807678
20Gingivitis (HP:0000230)3.41343753
21Albinism (HP:0001022)3.40506818
22Elevated erythrocyte sedimentation rate (HP:0003565)3.37420303
23Periodontitis (HP:0000704)3.34669242
24Recurrent skin infections (HP:0001581)3.29838852
25Aplasia/Hypoplasia affecting the retina (HP:0008061)3.20319376
26Disinhibition (HP:0000734)3.14813442
27Dysostosis multiplex (HP:0000943)3.11687909
28Recurrent fungal infections (HP:0002841)3.07334069
29Generalized hypopigmentation of hair (HP:0011358)3.06228197
30Mediastinal lymphadenopathy (HP:0100721)3.01628731
31Axonal loss (HP:0003447)3.01604500
32Clumsiness (HP:0002312)3.01603627
33Stomatitis (HP:0010280)2.99432434
34Abnormality of the fovea (HP:0000493)2.95223265
35Congenital sensorineural hearing impairment (HP:0008527)2.89911410
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.86992039
37Pustule (HP:0200039)2.86926923
38Generalized hypopigmentation (HP:0007513)2.85975256
39Cerebral aneurysm (HP:0004944)2.85370313
40Loss of speech (HP:0002371)2.78860913
41Myositis (HP:0100614)2.78069623
42Abnormality of polysaccharide metabolism (HP:0011012)2.70996480
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70996480
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70996480
45Myocardial infarction (HP:0001658)2.70871296
46Systemic lupus erythematosus (HP:0002725)2.68086256
47Hematochezia (HP:0002573)2.66396596
48Congenital stationary night blindness (HP:0007642)2.62186382
49Protruding tongue (HP:0010808)2.61385162
50Mucopolysacchariduria (HP:0008155)2.61364360
51Urinary glycosaminoglycan excretion (HP:0003541)2.61364360
52Stomach cancer (HP:0012126)2.61352630
53Colitis (HP:0002583)2.59013691
54Osteolytic defects of the hand bones (HP:0009699)2.57438913
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.57438913
56Recurrent viral infections (HP:0004429)2.57094596
57Cellulitis (HP:0100658)2.54929289
58Interstitial pulmonary disease (HP:0006530)2.54016045
59Keratoconjunctivitis (HP:0001096)2.50179654
60Thick nail (HP:0001805)2.49718150
61Prostate neoplasm (HP:0100787)2.48934831
62Premature loss of primary teeth (HP:0006323)2.47729933
63Osteomyelitis (HP:0002754)2.43076723
64Encephalitis (HP:0002383)2.42373283
65Abnormal drinking behavior (HP:0030082)2.42339450
66Polydipsia (HP:0001959)2.42339450
67Global brain atrophy (HP:0002283)2.37402478
68Obstructive lung disease (HP:0006536)2.34114518
69Chronic obstructive pulmonary disease (HP:0006510)2.34114518
70Ulnar bowing (HP:0003031)2.29344851
71Attenuation of retinal blood vessels (HP:0007843)2.27022913
72Chronic mucocutaneous candidiasis (HP:0002728)2.26854028
73Recurrent cutaneous fungal infections (HP:0011370)2.26854028
74Abnormality of the renal cortex (HP:0011035)2.26853145
75Keratoconjunctivitis sicca (HP:0001097)2.26010740
76Thoracic kyphosis (HP:0002942)2.25721175
77Inflammation of the large intestine (HP:0002037)2.24726135
78Pathologic fracture (HP:0002756)2.23537614
79Abolished electroretinogram (ERG) (HP:0000550)2.21217597
80Leukocytosis (HP:0001974)2.19855391
81Hemoptysis (HP:0002105)2.19759674
82Orchitis (HP:0100796)2.19623352
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17651639
84Absent frontal sinuses (HP:0002688)2.16625996
85Gaze-evoked nystagmus (HP:0000640)2.15820620
86Hypopigmentation of the fundus (HP:0007894)2.15617107
87Urethral obstruction (HP:0000796)2.14996962
88Hypochromic anemia (HP:0001931)2.14702385
89Gingival bleeding (HP:0000225)2.13632480
90Severe visual impairment (HP:0001141)2.13563079
91Gastrointestinal inflammation (HP:0004386)2.13304161
92Abnormality of the thoracic spine (HP:0100711)2.13203525
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13047619
94Pulmonary infiltrates (HP:0002113)2.08306421
95Vasculitis (HP:0002633)2.06640337
96Impaired platelet aggregation (HP:0003540)2.05135172
97Abnormal platelet function (HP:0011869)2.05135172
98White forelock (HP:0002211)2.03482042
99Hypochromic microcytic anemia (HP:0004840)2.02862612
100Agnosia (HP:0010524)2.02787890
101Abnormality of B cell number (HP:0010975)2.02773665
102Abnormality of the fingertips (HP:0001211)2.02595421
103Genetic anticipation (HP:0003743)2.02354424
104Panhypogammaglobulinemia (HP:0003139)2.02325648
105Glomerulonephritis (HP:0000099)2.01536155
106Increased CSF protein (HP:0002922)1.99763072
107Absent speech (HP:0001344)1.96698784
108Vertebral compression fractures (HP:0002953)1.96396334
109Aortic aneurysm (HP:0004942)1.95853057
110Chronic otitis media (HP:0000389)1.95635404
111Upper motor neuron abnormality (HP:0002127)1.95326455
112Prolonged bleeding time (HP:0003010)1.94715853
113Restrictive lung disease (HP:0002091)1.94595730
114Fair hair (HP:0002286)1.94594628
115Bone pain (HP:0002653)1.93221501
116Abnormality of transition element cation homeostasis (HP:0011030)1.92911756
117Pancreatic cysts (HP:0001737)1.92431493
118Increased density of long bones (HP:0006392)1.92111089
119Urticaria (HP:0001025)1.91643675
120Widely spaced teeth (HP:0000687)1.91513021
121Amelogenesis imperfecta (HP:0000705)1.90531839
122Chronic hepatic failure (HP:0100626)1.88131156
123Polyuria (HP:0000103)1.86536591
124Hepatosplenomegaly (HP:0001433)1.86125235
125Frequent falls (HP:0002359)1.86112948
126Bruising susceptibility (HP:0000978)1.84987837
127Epistaxis (HP:0000421)1.84879058
128Tubular atrophy (HP:0000092)1.83916289
129Emphysema (HP:0002097)1.83661444
130Mitral valve prolapse (HP:0001634)1.83433245
131Progressive inability to walk (HP:0002505)1.83344405
132Abnormality of the periventricular white matter (HP:0002518)1.83095632
133Spondylolisthesis (HP:0003302)1.82920476
134Basal ganglia calcification (HP:0002135)1.82837067
135Dilatation of the ascending aorta (HP:0005111)1.82456982
136Abnormality of the lumbar spine (HP:0100712)1.82433360
137Peripheral demyelination (HP:0011096)1.81864132
138Nephritis (HP:0000123)1.81689867
139Amyloidosis (HP:0011034)1.80051295
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79303869
141Bile duct proliferation (HP:0001408)1.79070264
142Abnormal biliary tract physiology (HP:0012439)1.79070264
143Cheilitis (HP:0100825)1.78849107
144Bilateral sensorineural hearing impairment (HP:0008619)1.77535975
145Polyphagia (HP:0002591)1.76525054
146Retinal atrophy (HP:0001105)1.76494377
147Neurodegeneration (HP:0002180)1.73995155
148Abnormality of the pleura (HP:0002103)1.73091873
149Type II lissencephaly (HP:0007260)1.72930766
150Tented upper lip vermilion (HP:0010804)1.72221297
151Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72115068
152Mesangial abnormality (HP:0001966)1.71962201
153Radial bowing (HP:0002986)1.70965725
154Macular degeneration (HP:0000608)1.69300224
155Meningitis (HP:0001287)1.68269277
156Distal lower limb amyotrophy (HP:0008944)1.66786005
157Eosinophilia (HP:0001880)1.66435509
158Neuronal loss in central nervous system (HP:0002529)1.65652702
159Optic neuritis (HP:0100653)1.65053648
160Retrobulbar optic neuritis (HP:0100654)1.65053648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.88325671
2KIT3.19174988
3TRIB33.13315671
4MAP4K12.88298098
5TTN2.76079184
6TYK22.62782041
7ERN12.58663695
8RIPK42.51952092
9ADRBK22.50862270
10TBK12.34849551
11ACVR1B2.29145165
12IRAK32.19116967
13CAMK1D2.16466818
14BLK2.11186498
15TAOK32.08289942
16IRAK41.97701687
17BMPR1B1.92250575
18MAP3K141.89002130
19PKN21.87173915
20TNK21.84185360
21JAK31.82616737
22PTK61.82277206
23CDK121.81501198
24CAMK1G1.79024298
25MAP3K101.76621305
26RIPK11.74136478
27TGFBR21.71626058
28ZAP701.68095384
29JAK11.62771242
30SIK21.62681239
31CSF1R1.61459361
32STK101.57585252
33HCK1.53079791
34NEK91.51156802
35IKBKE1.50007718
36MAP3K131.43963950
37EPHB11.42141101
38MAP2K31.38935079
39IKBKB1.35656031
40CDC42BPA1.33701685
41OXSR11.32506890
42CDK61.31573660
43CSK1.30307953
44PIK3CG1.25466451
45RPS6KA41.23761594
46PINK11.19763150
47BTK1.19373422
48PAK41.15823073
49FES1.14873261
50SCYL21.10975113
51NEK21.10707303
52LRRK21.09227409
53SYK1.08675996
54PTK2B1.07790246
55LCK1.06312791
56PRKD21.03744559
57SIK11.02824772
58MAP3K91.02149597
59TXK0.98346161
60MAPK130.97323860
61ITK0.97301338
62TRPM70.96360480
63IRAK10.96011748
64FGR0.92489290
65MAP2K60.92070389
66JAK20.91903269
67INSRR0.90038940
68PRKAA20.88683310
69MARK30.86176393
70MAP3K30.86121735
71CHUK0.84232716
72GRK60.84067482
73PIM10.83855222
74FGFR40.82531046
75NME20.81317870
76LYN0.80285541
77MAP3K70.79942822
78EEF2K0.78899261
79GRK10.77474108
80DDR20.77315191
81TEC0.76807741
82WNK40.76270716
83FLT30.75159648
84EGFR0.74938355
85PDGFRB0.74542799
86MTOR0.73696076
87GRK70.72943574
88STK40.72923628
89CDK40.72722629
90MATK0.70720248
91WNK30.69863310
92BMX0.67381633
93TGFBR10.67244870
94CAMKK10.67071649
95CAMKK20.66583433
96MAPK110.64973483
97FGFR30.64090099
98MAP3K80.63791326
99BRD40.62806457
100ADRBK10.61293032
101PTK20.61165775
102MAP3K60.59767302
103SGK20.59646130
104STK30.59381102
105MAP3K110.59177696
106ABL10.58290426
107CAMK40.56635521
108PIM20.56104043
109CAMK10.55945717
110FER0.55030591
111PAK20.54106225
112MAPKAPK30.51768218
113ICK0.51470595
114MARK20.48855089
115MAP4K20.48353320
116CLK10.47165252
117PDK10.45960032
118NUAK10.45110593
119TAOK10.44743040
120RPS6KA60.44329081
121PDPK10.43879224
122TESK20.41848958
123STK390.41652099
124PRKCQ0.41337386
125SIK30.41166749
126FYN0.40154807
127MAPK120.40006055
128NTRK30.39153169
129SGK30.38971628
130PRKCZ0.38611001
131DAPK20.38522617
132RPS6KC10.38322046
133RPS6KL10.38322046
134MAPK70.37995308
135NLK0.37455233
136PDGFRA0.37089503
137PRKCH0.37038967
138STK380.36312711
139RPS6KA10.36082667
140MAP2K20.35110451
141IRAK20.35023387
142ATR0.33972596
143RPS6KA20.33721447
144SRC0.33710028
145YES10.31937472
146MAPKAPK20.31428141
147ALK0.30455568
148KDR0.29430138

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.69958995
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.67823354
3Lysosome_Homo sapiens_hsa041422.61542831
4Caffeine metabolism_Homo sapiens_hsa002322.57906282
5Osteoclast differentiation_Homo sapiens_hsa043802.53656448
6Staphylococcus aureus infection_Homo sapiens_hsa051502.44581028
7B cell receptor signaling pathway_Homo sapiens_hsa046622.29957157
8Other glycan degradation_Homo sapiens_hsa005112.12436258
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.05883906
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01032181
11Tuberculosis_Homo sapiens_hsa051521.96566907
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.94750035
13Malaria_Homo sapiens_hsa051441.90803177
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90495326
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.86409653
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80180273
17Pertussis_Homo sapiens_hsa051331.72929742
18Measles_Homo sapiens_hsa051621.68558991
19Autoimmune thyroid disease_Homo sapiens_hsa053201.65418646
20ABC transporters_Homo sapiens_hsa020101.64708931
21Toxoplasmosis_Homo sapiens_hsa051451.63402238
22Linoleic acid metabolism_Homo sapiens_hsa005911.61009582
23Apoptosis_Homo sapiens_hsa042101.59376258
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57802233
25Legionellosis_Homo sapiens_hsa051341.56802289
26Chronic myeloid leukemia_Homo sapiens_hsa052201.55939967
27Antigen processing and presentation_Homo sapiens_hsa046121.51188298
28Phagosome_Homo sapiens_hsa041451.49740604
29Influenza A_Homo sapiens_hsa051641.47428070
30TNF signaling pathway_Homo sapiens_hsa046681.44444733
31Type I diabetes mellitus_Homo sapiens_hsa049401.42489785
32Shigellosis_Homo sapiens_hsa051311.40656666
33Hematopoietic cell lineage_Homo sapiens_hsa046401.40490916
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38843465
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34517654
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34422298
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.32810863
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31664827
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30419924
40Acute myeloid leukemia_Homo sapiens_hsa052211.29205869
41Ether lipid metabolism_Homo sapiens_hsa005651.27110932
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26948882
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20525205
44Small cell lung cancer_Homo sapiens_hsa052221.19354072
45Tryptophan metabolism_Homo sapiens_hsa003801.19174276
46Pancreatic cancer_Homo sapiens_hsa052121.17902061
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17071940
48Primary immunodeficiency_Homo sapiens_hsa053401.15886239
49Hepatitis B_Homo sapiens_hsa051611.15783051
50Dorso-ventral axis formation_Homo sapiens_hsa043201.14303225
51Rheumatoid arthritis_Homo sapiens_hsa053231.12878273
52Salmonella infection_Homo sapiens_hsa051321.11177459
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10669528
54T cell receptor signaling pathway_Homo sapiens_hsa046601.07788744
55Nitrogen metabolism_Homo sapiens_hsa009101.07092610
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.07074569
57Chemokine signaling pathway_Homo sapiens_hsa040621.06945741
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05140196
59Herpes simplex infection_Homo sapiens_hsa051681.03390201
60Amoebiasis_Homo sapiens_hsa051461.01053002
61Platelet activation_Homo sapiens_hsa046110.99956902
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97567319
63Hepatitis C_Homo sapiens_hsa051600.96711298
64Glycerolipid metabolism_Homo sapiens_hsa005610.95421505
65Proteoglycans in cancer_Homo sapiens_hsa052050.93922814
66Selenocompound metabolism_Homo sapiens_hsa004500.92958825
67Lysine degradation_Homo sapiens_hsa003100.92873192
68Viral myocarditis_Homo sapiens_hsa054160.92570334
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.92259207
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.91240549
71Butanoate metabolism_Homo sapiens_hsa006500.90893805
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.90278528
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89992802
74Regulation of autophagy_Homo sapiens_hsa041400.88525408
75Arachidonic acid metabolism_Homo sapiens_hsa005900.86978340
76MicroRNAs in cancer_Homo sapiens_hsa052060.85457304
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.79361135
78Insulin resistance_Homo sapiens_hsa049310.78865755
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78612741
80Ovarian steroidogenesis_Homo sapiens_hsa049130.77895689
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77507912
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76994447
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76715754
84mTOR signaling pathway_Homo sapiens_hsa041500.76626468
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75693526
86Chemical carcinogenesis_Homo sapiens_hsa052040.75315128
87Complement and coagulation cascades_Homo sapiens_hsa046100.73442362
88VEGF signaling pathway_Homo sapiens_hsa043700.73007310
89Focal adhesion_Homo sapiens_hsa045100.72967972
90Viral carcinogenesis_Homo sapiens_hsa052030.72064578
91Notch signaling pathway_Homo sapiens_hsa043300.71773622
92Morphine addiction_Homo sapiens_hsa050320.70936656
93Epstein-Barr virus infection_Homo sapiens_hsa051690.67412794
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67398619
95Non-small cell lung cancer_Homo sapiens_hsa052230.67138111
96HIF-1 signaling pathway_Homo sapiens_hsa040660.66408775
97HTLV-I infection_Homo sapiens_hsa051660.65722675
98Taste transduction_Homo sapiens_hsa047420.64031059
99Type II diabetes mellitus_Homo sapiens_hsa049300.63505623
100Phototransduction_Homo sapiens_hsa047440.62749008
101Endocytosis_Homo sapiens_hsa041440.61832157
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61356124
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.60710747
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60674607
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59538728
106ECM-receptor interaction_Homo sapiens_hsa045120.58930918
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58519188
108Renin-angiotensin system_Homo sapiens_hsa046140.57591672
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.57432143
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.56717599
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56497937
112Olfactory transduction_Homo sapiens_hsa047400.55729493
113Prolactin signaling pathway_Homo sapiens_hsa049170.53906351
114Salivary secretion_Homo sapiens_hsa049700.53672628
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53355154
116Colorectal cancer_Homo sapiens_hsa052100.53175536
117Circadian entrainment_Homo sapiens_hsa047130.52107395
118Graft-versus-host disease_Homo sapiens_hsa053320.51643651
119Inositol phosphate metabolism_Homo sapiens_hsa005620.50600579
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50532166
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50365594
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49364533
123Renal cell carcinoma_Homo sapiens_hsa052110.49269312
124Prostate cancer_Homo sapiens_hsa052150.48830169
125p53 signaling pathway_Homo sapiens_hsa041150.48255298
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.47887532
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46792672
128Allograft rejection_Homo sapiens_hsa053300.46051498
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45087403
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.44637329
131MAPK signaling pathway_Homo sapiens_hsa040100.44217160
132Asthma_Homo sapiens_hsa053100.41694974
133Sphingolipid metabolism_Homo sapiens_hsa006000.41521650
134Fatty acid degradation_Homo sapiens_hsa000710.41404657
135Long-term depression_Homo sapiens_hsa047300.41368316
136Glioma_Homo sapiens_hsa052140.41290476
137African trypanosomiasis_Homo sapiens_hsa051430.40980609
138FoxO signaling pathway_Homo sapiens_hsa040680.40565951
139Glutamatergic synapse_Homo sapiens_hsa047240.40543395
140Collecting duct acid secretion_Homo sapiens_hsa049660.40187867

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