TP53TG3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.04127470
2acrosome reaction (GO:0007340)8.13077085
3sperm motility (GO:0030317)7.96983624
4plasma membrane fusion (GO:0045026)6.92532628
5male meiosis (GO:0007140)6.87710536
6multicellular organism reproduction (GO:0032504)6.36224998
7binding of sperm to zona pellucida (GO:0007339)6.14598366
8sperm-egg recognition (GO:0035036)5.95888076
9spermatid development (GO:0007286)5.74368522
10microtubule depolymerization (GO:0007019)5.67343744
11piRNA metabolic process (GO:0034587)5.44710730
12synapsis (GO:0007129)5.39074135
13reproduction (GO:0000003)5.24370940
14motile cilium assembly (GO:0044458)5.14106952
15polyamine biosynthetic process (GO:0006596)5.00787700
16male meiosis I (GO:0007141)4.98497251
17chromosome organization involved in meiosis (GO:0070192)4.97728001
18synaptonemal complex assembly (GO:0007130)4.93817572
19cell-cell recognition (GO:0009988)4.89941561
20axonemal dynein complex assembly (GO:0070286)4.89113239
21calcium ion-dependent exocytosis (GO:0017156)4.73031112
22meiosis I (GO:0007127)4.68059847
23rRNA methylation (GO:0031167)4.62868229
24regulation of meiosis I (GO:0060631)4.60203771
25synaptonemal complex organization (GO:0070193)4.58519976
26cellular ketone body metabolic process (GO:0046950)4.56606050
27positive regulation of catecholamine secretion (GO:0033605)4.50248605
28sperm capacitation (GO:0048240)4.49337624
29DNA methylation involved in gamete generation (GO:0043046)4.42348393
30response to pheromone (GO:0019236)4.35381212
31single fertilization (GO:0007338)4.30273171
32thrombin receptor signaling pathway (GO:0070493)4.26743784
33negative regulation of norepinephrine secretion (GO:0010700)4.23485193
34ketone body metabolic process (GO:1902224)4.23315513
35spermatid nucleus differentiation (GO:0007289)4.21599507
36meiotic nuclear division (GO:0007126)4.20534042
37regulation of phosphoprotein phosphatase activity (GO:0043666)4.14766772
38spermatogenesis (GO:0007283)4.12787363
39male gamete generation (GO:0048232)4.11848905
40regulation of cilium movement (GO:0003352)4.09634371
41protein neddylation (GO:0045116)4.08780177
42positive regulation of endothelial cell differentiation (GO:0045603)4.05804721
43microtubule polymerization or depolymerization (GO:0031109)4.03627177
44DNA packaging (GO:0006323)3.98464185
45regulation of female receptivity (GO:0045924)3.98258934
46negative regulation of heart rate (GO:0010459)3.95357321
47negative regulation of inclusion body assembly (GO:0090084)3.94709579
48single strand break repair (GO:0000012)3.92285807
49gamete generation (GO:0007276)3.84020579
50blood coagulation, intrinsic pathway (GO:0007597)3.81401444
51epithelial cilium movement (GO:0003351)3.80533437
52chromosome condensation (GO:0030261)3.79919140
53negative regulation of homotypic cell-cell adhesion (GO:0034111)3.78359619
54fertilization (GO:0009566)3.75086480
55germ cell development (GO:0007281)3.73674493
56negative regulation of platelet activation (GO:0010544)3.73594838
57cilium or flagellum-dependent cell motility (GO:0001539)3.72928847
58rRNA modification (GO:0000154)3.67543893
59detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.66847354
60coenzyme catabolic process (GO:0009109)3.64165303
61centriole replication (GO:0007099)3.62422413
62cellular biogenic amine biosynthetic process (GO:0042401)3.59763941
63regulation of platelet activation (GO:0010543)3.57765348
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.55052239
65relaxation of smooth muscle (GO:0044557)3.54100402
66neutrophil activation involved in immune response (GO:0002283)3.52722410
67amine biosynthetic process (GO:0009309)3.52008813
68centriole assembly (GO:0098534)3.50662497
69regulation of oxidative phosphorylation (GO:0002082)3.48964843
70female mating behavior (GO:0060180)3.44097549
71negative regulation of response to food (GO:0032096)3.41423367
72negative regulation of appetite (GO:0032099)3.41423367
73organic cation transport (GO:0015695)3.36851807
74DNA synthesis involved in DNA repair (GO:0000731)3.33639754
75regulation of platelet aggregation (GO:0090330)3.28854508
76adenosine receptor signaling pathway (GO:0001973)3.27813971
77cellular process involved in reproduction in multicellular organism (GO:0022412)3.26008010
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25441799
79polyamine metabolic process (GO:0006595)3.22683422
80cilium movement (GO:0003341)3.20494976
81multicellular organismal reproductive process (GO:0048609)3.07515818
82xenobiotic catabolic process (GO:0042178)3.04306274
83response to acidic pH (GO:0010447)3.00912092
84meiotic cell cycle process (GO:1903046)3.00619076
85protein polyglutamylation (GO:0018095)2.99420791
86regulation of response to food (GO:0032095)2.97481948
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97068396
88lipoxygenase pathway (GO:0019372)2.92785434
89purinergic nucleotide receptor signaling pathway (GO:0035590)2.92674917
90ether metabolic process (GO:0018904)2.90142309
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.89390426
92L-phenylalanine catabolic process (GO:0006559)2.89390426
93negative regulation of thymocyte apoptotic process (GO:0070244)2.85743584
94sexual reproduction (GO:0019953)2.84529371
95negative regulation of catecholamine secretion (GO:0033604)2.83627733
96protein targeting to Golgi (GO:0000042)2.82153752
97poly(A)+ mRNA export from nucleus (GO:0016973)2.78931456
98regulation of norepinephrine secretion (GO:0014061)2.76584594
99positive regulation of cAMP-mediated signaling (GO:0043950)2.76309711
100positive regulation of meiosis (GO:0045836)2.75304568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82483095
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.73215513
3EZH2_22144423_ChIP-Seq_EOC_Human3.03400440
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54365902
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.52367384
6VDR_22108803_ChIP-Seq_LS180_Human2.31252791
7GBX2_23144817_ChIP-Seq_PC3_Human2.23399316
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10711985
9IGF1R_20145208_ChIP-Seq_DFB_Human2.08966668
10NANOG_20526341_ChIP-Seq_ESCs_Human2.03637716
11GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.03505952
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00513231
13ER_23166858_ChIP-Seq_MCF-7_Human1.97568394
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97054702
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.93382746
16GATA1_19941826_ChIP-Seq_K562_Human1.88692774
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84882440
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.83442600
19CBP_20019798_ChIP-Seq_JUKART_Human1.76980844
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76980844
21ERA_21632823_ChIP-Seq_H3396_Human1.73489899
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72691816
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72691816
24GATA3_21878914_ChIP-Seq_MCF-7_Human1.72085180
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70714334
26GATA2_19941826_ChIP-Seq_K562_Human1.70542903
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69681764
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68476047
29AR_25329375_ChIP-Seq_VCAP_Human1.68347880
30HNFA_21074721_ChIP-Seq_CACO-2_Human1.67561523
31TAF15_26573619_Chip-Seq_HEK293_Human1.67191806
32SCL_19346495_ChIP-Seq_HPC-7_Human1.65526854
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63880460
34EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.63251294
35RBPJ_21746931_ChIP-Seq_IB4_Human1.60478336
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.59803084
37TBL1_22424771_ChIP-Seq_293T_Human1.59548871
38FUS_26573619_Chip-Seq_HEK293_Human1.59333200
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.59245166
40PHF8_20622853_ChIP-Seq_HELA_Human1.56834000
41RAC3_21632823_ChIP-Seq_H3396_Human1.56299150
42NFYB_21822215_ChIP-Seq_K562_Human1.53375088
43CTCF_20526341_ChIP-Seq_ESCs_Human1.51947562
44OCT1_27270436_Chip-Seq_PROSTATE_Human1.51591264
45OCT4_20526341_ChIP-Seq_ESCs_Human1.50629266
46ETV1_20927104_ChIP-Seq_GIST48_Human1.49381965
47HTT_18923047_ChIP-ChIP_STHdh_Human1.46589466
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.46522949
49STAT1_20625510_ChIP-Seq_HELA_Human1.45126448
50ERG_20517297_ChIP-Seq_VCAP_Human1.44648030
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.44542892
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44135822
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44066968
54SPI1_20517297_ChIP-Seq_HL60_Human1.43874436
55MYC_19829295_ChIP-Seq_ESCs_Human1.40756992
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.40695248
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40437569
58SOX2_19829295_ChIP-Seq_ESCs_Human1.38119883
59NANOG_19829295_ChIP-Seq_ESCs_Human1.38119883
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.37797451
61SMAD4_21799915_ChIP-Seq_A2780_Human1.36905273
62NFYA_21822215_ChIP-Seq_K562_Human1.36542309
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.35506295
64BCAT_22108803_ChIP-Seq_LS180_Human1.34046905
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33177407
66BCL6_27268052_Chip-Seq_Bcells_Human1.32223632
67CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30585403
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.29223963
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28333402
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.27995433
71ZNF274_21170338_ChIP-Seq_K562_Hela1.26696201
72P300_19829295_ChIP-Seq_ESCs_Human1.24195698
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24115918
74SPI1_23127762_ChIP-Seq_K562_Human1.24108772
75ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23610124
76P300_27268052_Chip-Seq_Bcells_Human1.21788891
77BCOR_27268052_Chip-Seq_Bcells_Human1.21346523
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21223847
79STAT3_23295773_ChIP-Seq_U87_Human1.20349543
80HOXB7_26014856_ChIP-Seq_BT474_Human1.20151491
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19255746
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18452235
83TAF2_19829295_ChIP-Seq_ESCs_Human1.18410318
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17645062
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14658619
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14566837
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14271682
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14147448
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13994975
90E2F1_20622854_ChIP-Seq_HELA_Human1.13427912
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13280956
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13272875
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.12851289
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.12304579
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12304579
96SALL4_22934838_ChIP-ChIP_CD34+_Human1.11442282
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11114320
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10835057
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08560454
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08557626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.59005465
2MP0005464_abnormal_platelet_physiology5.37327158
3MP0008004_abnormal_stomach_pH4.19045646
4MP0003698_abnormal_male_reproductive3.30568897
5MP0002132_abnormal_respiratory_system3.15539613
6MP0001929_abnormal_gametogenesis3.10580945
7MP0003718_maternal_effect3.01047486
8MP0008877_abnormal_DNA_methylation2.74487717
9MP0003806_abnormal_nucleotide_metabolis2.27021076
10MP0005646_abnormal_pituitary_gland2.24700448
11MP0003136_yellow_coat_color2.23963671
12MP0009697_abnormal_copulation2.05481772
13MP0002160_abnormal_reproductive_system2.05277021
14MP0010386_abnormal_urinary_bladder2.04413564
15MP0002210_abnormal_sex_determination2.03670568
16MP0005083_abnormal_biliary_tract2.02587419
17MP0003879_abnormal_hair_cell1.90833543
18MP0005058_abnormal_lysosome_morphology1.88935890
19MP0005397_hematopoietic_system_phenotyp1.87862950
20MP0001545_abnormal_hematopoietic_system1.87862950
21MP0004084_abnormal_cardiac_muscle1.78772657
22MP0000230_abnormal_systemic_arterial1.76326339
23MP0001879_abnormal_lymphatic_vessel1.75777084
24MP0002161_abnormal_fertility/fecundity1.72155750
25MP0004036_abnormal_muscle_relaxation1.66998567
26MP0000653_abnormal_sex_gland1.62821957
27MP0008775_abnormal_heart_ventricle1.62301135
28MP0001145_abnormal_male_reproductive1.59124805
29MP0001968_abnormal_touch/_nociception1.51788488
30MP0000465_gastrointestinal_hemorrhage1.49638579
31MP0005389_reproductive_system_phenotype1.44342643
32MP0009278_abnormal_bone_marrow1.42257767
33MP0000372_irregular_coat_pigmentation1.42159998
34MP0009780_abnormal_chondrocyte_physiolo1.37197374
35MP0005647_abnormal_sex_gland1.36351816
36MP0002735_abnormal_chemical_nociception1.33567570
37MP0008872_abnormal_physiological_respon1.32481629
38MP0006276_abnormal_autonomic_nervous1.29057549
39MP0002736_abnormal_nociception_after1.28558736
40MP0001765_abnormal_ion_homeostasis1.25912441
41MP0005187_abnormal_penis_morphology1.25830779
42MP0000678_abnormal_parathyroid_gland1.25542111
43MP0004510_myositis1.24188563
44MP0002733_abnormal_thermal_nociception1.21804949
45MP0000015_abnormal_ear_pigmentation1.20871914
46MP0005174_abnormal_tail_pigmentation1.19687043
47MP0010368_abnormal_lymphatic_system1.16657200
48MP0005084_abnormal_gallbladder_morpholo1.11484024
49MP0006036_abnormal_mitochondrial_physio1.10757836
50MP0005670_abnormal_white_adipose1.09195119
51MP0000343_altered_response_to1.08895643
52MP0001661_extended_life_span1.08687253
53MP0001905_abnormal_dopamine_level1.07983939
54MP0003638_abnormal_response/metabolism_1.06692546
55MP0005167_abnormal_blood-brain_barrier1.05629063
56MP0003724_increased_susceptibility_to1.04724776
57MP0005395_other_phenotype1.02178941
58MP0004085_abnormal_heartbeat1.01210004
59MP0001664_abnormal_digestion0.99969748
60MP0001919_abnormal_reproductive_system0.99078958
61MP0005377_hearing/vestibular/ear_phenot0.97416619
62MP0003878_abnormal_ear_physiology0.97416619
63MP0005360_urolithiasis0.96167103
64MP0004215_abnormal_myocardial_fiber0.95653531
65MP0001970_abnormal_pain_threshold0.93034044
66MP0008995_early_reproductive_senescence0.91096678
67MP0005551_abnormal_eye_electrophysiolog0.89660800
68MP0005451_abnormal_body_composition0.82456228
69MP0001984_abnormal_olfaction0.79717324
70MP0008058_abnormal_DNA_repair0.78784758
71MP0001501_abnormal_sleep_pattern0.78412654
72MP0002653_abnormal_ependyma_morphology0.78301493
73MP0005645_abnormal_hypothalamus_physiol0.77536500
74MP0005379_endocrine/exocrine_gland_phen0.74615863
75MP0001756_abnormal_urination0.73404501
76MP0002127_abnormal_cardiovascular_syste0.72878549
77MP0005535_abnormal_body_temperature0.69715073
78MP0001485_abnormal_pinna_reflex0.69480751
79MP0005636_abnormal_mineral_homeostasis0.68470559
80MP0004019_abnormal_vitamin_homeostasis0.67628192
81MP0003699_abnormal_female_reproductive0.63685894
82MP0005409_darkened_coat_color0.61735403
83MP0002272_abnormal_nervous_system0.61260143
84MP0000358_abnormal_cell_content/0.58254761
85MP0001666_abnormal_nutrient_absorption0.56941421
86MP0009046_muscle_twitch0.56479311
87MP0000681_abnormal_thyroid_gland0.56441260
88MP0009642_abnormal_blood_homeostasis0.55900313
89MP0001119_abnormal_female_reproductive0.55604163
90MP0003011_delayed_dark_adaptation0.55473334
91MP0000249_abnormal_blood_vessel0.54231239
92MP0001963_abnormal_hearing_physiology0.53578920
93MP0002067_abnormal_sensory_capabilities0.53502114
94MP0002118_abnormal_lipid_homeostasis0.48961233
95MP0002837_dystrophic_cardiac_calcinosis0.47684944
96MP0002229_neurodegeneration0.46130540
97MP0002078_abnormal_glucose_homeostasis0.44793631
98MP0005253_abnormal_eye_physiology0.43851916
99MP0002102_abnormal_ear_morphology0.43711083
100MP0001764_abnormal_homeostasis0.43316918

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.70830786
2Menorrhagia (HP:0000132)6.87808900
3Petechiae (HP:0000967)6.19558841
4Increased mean platelet volume (HP:0011877)5.86536463
5Absent/shortened dynein arms (HP:0200106)5.61231017
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.61231017
7Purpura (HP:0000979)5.46085089
8Abnormal platelet volume (HP:0011876)5.36718475
9Abnormal ciliary motility (HP:0012262)5.09933452
10Abnormal respiratory epithelium morphology (HP:0012253)4.82197735
11Abnormal respiratory motile cilium morphology (HP:0005938)4.82197735
12Epistaxis (HP:0000421)4.78489813
13Hyperlipoproteinemia (HP:0010980)4.53257463
14Abnormal respiratory motile cilium physiology (HP:0012261)4.34549572
15Severe visual impairment (HP:0001141)4.25888793
16Infertility (HP:0000789)4.22106921
17Resting tremor (HP:0002322)4.17466842
18Male infertility (HP:0003251)3.99822850
19Generalized aminoaciduria (HP:0002909)3.88485182
20Gingival bleeding (HP:0000225)3.58417739
21Abnormal pupillary function (HP:0007686)3.46081580
22Abnormality of lateral ventricle (HP:0030047)3.45890963
23Congenital sensorineural hearing impairment (HP:0008527)3.44967965
24Attenuation of retinal blood vessels (HP:0007843)3.28328956
25Abnormal platelet function (HP:0011869)3.19922939
26Impaired platelet aggregation (HP:0003540)3.19922939
27Poikilocytosis (HP:0004447)3.16100835
28Decreased central vision (HP:0007663)3.12653770
29Bony spicule pigmentary retinopathy (HP:0007737)3.07782253
30Hyperthyroidism (HP:0000836)3.06405939
31Acanthocytosis (HP:0001927)3.01597195
32Dyschromatopsia (HP:0007641)2.97555758
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96353470
34Ventricular fibrillation (HP:0001663)2.93639357
35Azoospermia (HP:0000027)2.93485502
36Upper limb muscle weakness (HP:0003484)2.84367970
37Abnormal spermatogenesis (HP:0008669)2.81151912
38Rhinitis (HP:0012384)2.80156401
39Abnormality of the costochondral junction (HP:0000919)2.74186962
40Hypophosphatemic rickets (HP:0004912)2.73501029
41Abnormal rod and cone electroretinograms (HP:0008323)2.65004849
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.64461705
43Tubulointerstitial nephritis (HP:0001970)2.54804633
44Osteomalacia (HP:0002749)2.51878793
45Abnormal auditory evoked potentials (HP:0006958)2.42380547
46Rickets (HP:0002748)2.37938372
47Renal Fanconi syndrome (HP:0001994)2.36543671
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35005865
49Hypoplasia of the fovea (HP:0007750)2.32197454
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.32197454
51Paralysis (HP:0003470)2.31498103
52Xanthomatosis (HP:0000991)2.29396815
53Postural instability (HP:0002172)2.28710294
54Nasal polyposis (HP:0100582)2.26953033
55Enlarged epiphyses (HP:0010580)2.24454737
56Abnormality of macular pigmentation (HP:0008002)2.18688299
57Conjunctival telangiectasia (HP:0000524)2.15087313
58Abnormality of the fovea (HP:0000493)2.12694246
59Hypoplasia of the uterus (HP:0000013)2.11751595
60Bruising susceptibility (HP:0000978)2.00284255
61Male pseudohermaphroditism (HP:0000037)1.98711442
62Gonadal dysgenesis (HP:0000133)1.95195075
63Median cleft lip (HP:0000161)1.94967289
64Spontaneous abortion (HP:0005268)1.94512050
65Tinnitus (HP:0000360)1.92630511
66Clumsiness (HP:0002312)1.89136998
67Horizontal nystagmus (HP:0000666)1.87867345
68Atonic seizures (HP:0010819)1.83217647
69Abnormality of the nasal mucosa (HP:0000433)1.82431168
70Widely patent fontanelles and sutures (HP:0004492)1.80433807
71Aplasia/Hypoplasia of the earlobes (HP:0009906)1.79994137
72Hypergonadotropic hypogonadism (HP:0000815)1.79636685
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76528638
74Chronic sinusitis (HP:0011109)1.74314355
75Spontaneous hematomas (HP:0007420)1.72317232
76Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69348769
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69348769
78Difficulty walking (HP:0002355)1.66688055
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64120616
80Abnormality of renal resorption (HP:0011038)1.62926297
81Abnormality of the vasculature of the conjunctiva (HP:0008054)1.62522357
82Abnormality of dental color (HP:0011073)1.60408207
83Absent thumb (HP:0009777)1.60348122
84Portal hypertension (HP:0001409)1.56239856
85Glycosuria (HP:0003076)1.56203500
86Abnormality of urine glucose concentration (HP:0011016)1.56203500
87Protuberant abdomen (HP:0001538)1.55340098
88Bronchiectasis (HP:0002110)1.55049575
89Truncus arteriosus (HP:0001660)1.54059887
90Enlarged kidneys (HP:0000105)1.51715292
91Abnormal drinking behavior (HP:0030082)1.51673195
92Polydipsia (HP:0001959)1.51673195
93Hypoplastic ischia (HP:0003175)1.50948976
94Atelectasis (HP:0100750)1.50642179
95Hypoglycemic coma (HP:0001325)1.50621463
96Scotoma (HP:0000575)1.49942969
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.49163356
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47452422
99Insulin-resistant diabetes mellitus (HP:0000831)1.47261065
100Potter facies (HP:0002009)1.47091332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.40844536
2PLK43.56976927
3MST43.52916181
4MYLK3.52367563
5PNCK3.27202607
6PTK2B2.86582336
7MARK32.84732950
8ZAK2.69089308
9MAP4K22.63229919
10BMX2.55020292
11TESK12.39421233
12FRK2.27020918
13PLK22.25342664
14EIF2AK12.24921101
15RIPK42.04885504
16INSRR1.98442754
17ARAF1.94407831
18STK31.76046392
19DDR21.75708512
20ACVR1B1.71638133
21GRK51.62215976
22TLK11.49969299
23MAP3K21.47836123
24BTK1.39794949
25ILK1.39615325
26PIK3CG1.35767110
27STK381.32447588
28TEC1.26686658
29TAOK31.26447086
30NUAK11.20168411
31MAP3K91.19911523
32PAK11.14927583
33BMPR1B1.12113155
34FGR1.08486537
35ADRBK21.03822143
36MAPK151.01025614
37MAPKAPK30.95609903
38MET0.94850363
39BMPR20.91939859
40GRK60.91661356
41TNK20.88610979
42STK38L0.86250005
43NEK20.86081621
44CSF1R0.85107151
45ICK0.83751812
46SYK0.83199467
47CDK30.79412273
48TESK20.78071253
49KSR20.77968920
50BRAF0.76247729
51MAP3K10.76073260
52PKN10.75335389
53PRKG10.73421407
54DAPK30.72855676
55PDPK10.72659214
56RPS6KA50.72373180
57PDK10.71917579
58NTRK30.69729448
59WNK10.69007211
60MST1R0.67792279
61MOS0.66219360
62RAF10.62598789
63CDK70.61830297
64RET0.60547925
65STK40.59694961
66GRK10.57732961
67DAPK20.55358355
68WEE10.55254420
69LATS10.52164310
70LMTK20.50706103
71MAP2K70.50399313
72ROCK10.50157179
73FER0.49818155
74WNK40.49520965
75CDK80.49031258
76CAMK1G0.48397513
77MAP3K130.46504676
78MAP2K10.46220036
79PRKG20.44485210
80CDK140.42676486
81AURKA0.42290758
82OBSCN0.42050388
83ZAP700.40772375
84PRKCQ0.37875533
85CCNB10.32777573
86HCK0.32372742
87CLK10.30817515
88IKBKB0.29249613
89DYRK30.27952530
90CDK190.27663615
91MAP3K50.26189330
92ADRBK10.25440481
93LYN0.24902436
94MAPK110.24794639
95PHKG20.24733571
96PHKG10.24733571
97MAPKAPK20.22548106
98MATK0.22322944
99VRK10.21982576
100MAPK130.20421963

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.01342308
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.98244147
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.63804852
4Platelet activation_Homo sapiens_hsa046113.11862651
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.85863463
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.59038597
7Gap junction_Homo sapiens_hsa045402.46274134
8Nitrogen metabolism_Homo sapiens_hsa009102.26578698
9Butanoate metabolism_Homo sapiens_hsa006502.16543196
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.02063133
11Mismatch repair_Homo sapiens_hsa034301.73355027
12Regulation of autophagy_Homo sapiens_hsa041401.70312198
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65691254
14Glutathione metabolism_Homo sapiens_hsa004801.61394251
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.56675426
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.52187103
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.49242496
18Chemical carcinogenesis_Homo sapiens_hsa052041.49098381
19Arachidonic acid metabolism_Homo sapiens_hsa005901.48558729
20Alcoholism_Homo sapiens_hsa050341.48382437
21Fatty acid biosynthesis_Homo sapiens_hsa000611.44454098
22ECM-receptor interaction_Homo sapiens_hsa045121.42327013
23Oocyte meiosis_Homo sapiens_hsa041141.40702879
24Tyrosine metabolism_Homo sapiens_hsa003501.39552894
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38498098
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28309124
27Systemic lupus erythematosus_Homo sapiens_hsa053221.26708807
28Dorso-ventral axis formation_Homo sapiens_hsa043201.23456333
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22397055
30Taste transduction_Homo sapiens_hsa047421.21287639
31Phototransduction_Homo sapiens_hsa047441.18352437
32Fanconi anemia pathway_Homo sapiens_hsa034601.14681718
33Serotonergic synapse_Homo sapiens_hsa047261.14459091
34beta-Alanine metabolism_Homo sapiens_hsa004101.12168518
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.12038868
36Calcium signaling pathway_Homo sapiens_hsa040201.06683586
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06000529
38Basal transcription factors_Homo sapiens_hsa030221.05652751
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04849450
40Homologous recombination_Homo sapiens_hsa034401.04019198
41Glycerolipid metabolism_Homo sapiens_hsa005611.01090044
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00570981
43Phagosome_Homo sapiens_hsa041451.00458694
44ABC transporters_Homo sapiens_hsa020100.98016444
45Synaptic vesicle cycle_Homo sapiens_hsa047210.96347930
46Sulfur metabolism_Homo sapiens_hsa009200.94674485
47Retinol metabolism_Homo sapiens_hsa008300.94023516
48Starch and sucrose metabolism_Homo sapiens_hsa005000.91871555
49Hematopoietic cell lineage_Homo sapiens_hsa046400.91463667
50Endocytosis_Homo sapiens_hsa041440.90497972
51Collecting duct acid secretion_Homo sapiens_hsa049660.89443862
52Circadian entrainment_Homo sapiens_hsa047130.88558660
53Purine metabolism_Homo sapiens_hsa002300.88078858
54Phenylalanine metabolism_Homo sapiens_hsa003600.80221879
55Sulfur relay system_Homo sapiens_hsa041220.77768157
56Fatty acid elongation_Homo sapiens_hsa000620.75462369
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74143534
58Pancreatic secretion_Homo sapiens_hsa049720.72365343
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.69643504
60Arginine and proline metabolism_Homo sapiens_hsa003300.68933262
61Morphine addiction_Homo sapiens_hsa050320.67730197
62Type II diabetes mellitus_Homo sapiens_hsa049300.66794944
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66574615
64Renin-angiotensin system_Homo sapiens_hsa046140.65869084
65Renin secretion_Homo sapiens_hsa049240.65475077
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64663269
67GABAergic synapse_Homo sapiens_hsa047270.64265023
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59591913
69Linoleic acid metabolism_Homo sapiens_hsa005910.53977934
70PPAR signaling pathway_Homo sapiens_hsa033200.53958143
71Fatty acid metabolism_Homo sapiens_hsa012120.53402283
72Apoptosis_Homo sapiens_hsa042100.51673559
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49873659
74Fatty acid degradation_Homo sapiens_hsa000710.49873272
75Folate biosynthesis_Homo sapiens_hsa007900.48962521
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47374050
77Salivary secretion_Homo sapiens_hsa049700.43900420
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43361997
79Gastric acid secretion_Homo sapiens_hsa049710.43047213
80Arginine biosynthesis_Homo sapiens_hsa002200.41796072
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38033688
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.37959186
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37862080
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36368252
85Nicotine addiction_Homo sapiens_hsa050330.36303108
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35808195
87Peroxisome_Homo sapiens_hsa041460.34981414
88Metabolic pathways_Homo sapiens_hsa011000.34636642
89Long-term depression_Homo sapiens_hsa047300.33863455
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.33569968
91Chemokine signaling pathway_Homo sapiens_hsa040620.32526832
92Insulin secretion_Homo sapiens_hsa049110.32424770
93Oxytocin signaling pathway_Homo sapiens_hsa049210.32415080
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31549616
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31011397
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30389028
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29507463
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27911891
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27231435
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25854997

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »