TP53AIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.86592469
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.37383051
3pyrimidine nucleobase catabolic process (GO:0006208)5.62132841
4cilium movement (GO:0003341)5.39236132
5epithelial cilium movement (GO:0003351)5.36956335
6cilium or flagellum-dependent cell motility (GO:0001539)5.15967112
7nucleobase catabolic process (GO:0046113)4.61015205
8molting cycle (GO:0042303)4.58014409
9hair cycle (GO:0042633)4.58014409
10keratinization (GO:0031424)4.43128031
11regulation of cilium movement (GO:0003352)4.32715368
12establishment of skin barrier (GO:0061436)4.26275731
13hemidesmosome assembly (GO:0031581)4.23986261
14regulation of microtubule-based movement (GO:0060632)4.21693603
15intraciliary transport (GO:0042073)4.15794992
16keratinocyte development (GO:0003334)4.11791901
17response to pheromone (GO:0019236)4.03397817
18axoneme assembly (GO:0035082)4.02426255
19behavioral response to nicotine (GO:0035095)3.98411704
20protein localization to cilium (GO:0061512)3.78149650
21water-soluble vitamin biosynthetic process (GO:0042364)3.64813802
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59575750
23motile cilium assembly (GO:0044458)3.50222133
24nonmotile primary cilium assembly (GO:0035058)3.44914191
25one-carbon compound transport (GO:0019755)3.44687102
26rRNA catabolic process (GO:0016075)3.40185618
27establishment of planar polarity (GO:0001736)3.38597875
28establishment of tissue polarity (GO:0007164)3.38597875
29piRNA metabolic process (GO:0034587)3.26800647
30regulation of water loss via skin (GO:0033561)3.25471204
31phosphatidylserine acyl-chain remodeling (GO:0036150)3.23550342
32parturition (GO:0007567)3.20197249
33axonal fasciculation (GO:0007413)3.18820090
34dendritic spine morphogenesis (GO:0060997)3.15817535
35cilium organization (GO:0044782)3.12012455
36cilium assembly (GO:0042384)3.08900430
37maternal behavior (GO:0042711)3.07823251
38neuron recognition (GO:0008038)3.06735952
39negative regulation of telomere maintenance (GO:0032205)3.04742145
40keratinocyte proliferation (GO:0043616)3.03475729
41desmosome organization (GO:0002934)3.03083208
42positive regulation of sodium ion transmembrane transport (GO:1902307)2.99874391
43male meiosis I (GO:0007141)2.97896645
44left/right pattern formation (GO:0060972)2.97198111
45L-fucose catabolic process (GO:0042355)2.94726403
46fucose catabolic process (GO:0019317)2.94726403
47L-fucose metabolic process (GO:0042354)2.94726403
48cornea development in camera-type eye (GO:0061303)2.91643444
49parental behavior (GO:0060746)2.91425288
50photoreceptor cell maintenance (GO:0045494)2.88316406
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.85784036
52cilium morphogenesis (GO:0060271)2.83842734
53left/right axis specification (GO:0070986)2.79322300
54synaptic transmission, cholinergic (GO:0007271)2.79243810
55glycerophospholipid catabolic process (GO:0046475)2.71834549
56detection of mechanical stimulus involved in sensory perception (GO:0050974)2.71644393
57phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71283151
58startle response (GO:0001964)2.69826780
59positive regulation of prostaglandin secretion (GO:0032308)2.69794391
60protein polyglutamylation (GO:0018095)2.69094774
61lateral sprouting from an epithelium (GO:0060601)2.69034702
62phosphatidylinositol acyl-chain remodeling (GO:0036149)2.66848634
63protein localization to synapse (GO:0035418)2.65412630
64kidney morphogenesis (GO:0060993)2.61213427
65male meiosis (GO:0007140)2.61085357
66negative regulation of T cell differentiation in thymus (GO:0033085)2.60357981
67regulation of axon regeneration (GO:0048679)2.60204300
68regulation of neuron projection regeneration (GO:0070570)2.60204300
69postsynaptic membrane organization (GO:0001941)2.57559314
70long-chain fatty acid biosynthetic process (GO:0042759)2.55723652
71DNA methylation involved in gamete generation (GO:0043046)2.51856680
72ubiquinone biosynthetic process (GO:0006744)2.51709595
73activated T cell proliferation (GO:0050798)2.50259527
74auditory behavior (GO:0031223)2.48859346
75microtubule bundle formation (GO:0001578)2.47400509
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47114359
77homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.47088572
78positive regulation of fatty acid transport (GO:2000193)2.47017980
79neurotransmitter catabolic process (GO:0042135)2.46900174
80negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.45980900
81retina layer formation (GO:0010842)2.45279636
82phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.44909397
83synapse assembly (GO:0007416)2.42829149
84alanine transport (GO:0032328)2.42697241
85sperm motility (GO:0030317)2.42318392
86epidermis development (GO:0008544)2.41696879
87positive regulation of gastrulation (GO:2000543)2.41050897
88nephron epithelium morphogenesis (GO:0072088)2.41023176
89nephron tubule morphogenesis (GO:0072078)2.41023176
90response to dietary excess (GO:0002021)2.39419353
91limb development (GO:0060173)2.38782924
92appendage development (GO:0048736)2.38782924
93ubiquinone metabolic process (GO:0006743)2.37722347
94lysine catabolic process (GO:0006554)2.36619929
95lysine metabolic process (GO:0006553)2.36619929
96short-term memory (GO:0007614)2.36408604
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36295204
98coenzyme catabolic process (GO:0009109)2.35491515
99intermediate filament organization (GO:0045109)2.33889393
100phosphatidylcholine acyl-chain remodeling (GO:0036151)2.33654618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.54538453
2EZH2_22144423_ChIP-Seq_EOC_Human3.54419273
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.96527827
4ZNF274_21170338_ChIP-Seq_K562_Hela2.86671728
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76044738
6VDR_22108803_ChIP-Seq_LS180_Human2.62952959
7IGF1R_20145208_ChIP-Seq_DFB_Human2.55018220
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34952142
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27877631
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16713454
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88193464
12CBX2_27304074_Chip-Seq_ESCs_Mouse1.87188443
13RNF2_27304074_Chip-Seq_NSC_Mouse1.86151905
14REST_21632747_ChIP-Seq_MESCs_Mouse1.83776709
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79514078
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.77543790
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76417122
18GBX2_23144817_ChIP-Seq_PC3_Human1.74441207
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.68406865
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63806849
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63564239
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63409772
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57326554
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57297820
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53998101
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53258995
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50093215
28TAF15_26573619_Chip-Seq_HEK293_Human1.47705655
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46671730
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.46301820
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42144980
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41561390
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.38690207
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.38293183
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37604554
36CBP_20019798_ChIP-Seq_JUKART_Human1.37604554
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36911696
38FUS_26573619_Chip-Seq_HEK293_Human1.36800228
39EWS_26573619_Chip-Seq_HEK293_Human1.34942563
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34724580
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34724580
42* P300_19829295_ChIP-Seq_ESCs_Human1.32684499
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29737730
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28257465
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28138539
46BCAT_22108803_ChIP-Seq_LS180_Human1.26284596
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24911888
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22612909
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22568841
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22568841
51ER_23166858_ChIP-Seq_MCF-7_Human1.22281028
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22124153
53NCOR_22424771_ChIP-Seq_293T_Human1.22027408
54IRF1_19129219_ChIP-ChIP_H3396_Human1.21857421
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20866783
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20210956
57AR_25329375_ChIP-Seq_VCAP_Human1.19781227
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19512735
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17351658
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16869959
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16401463
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15186786
63SMAD4_21799915_ChIP-Seq_A2780_Human1.12459819
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10003144
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09054686
66TP53_16413492_ChIP-PET_HCT116_Human1.07812717
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06266282
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.05069201
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04912425
70* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04583819
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.04329385
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.03317708
73HTT_18923047_ChIP-ChIP_STHdh_Human1.03116247
74STAT3_23295773_ChIP-Seq_U87_Human1.02400625
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.01073087
76SMAD3_21741376_ChIP-Seq_HESCs_Human0.98998148
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.98698440
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98698440
79TAF2_19829295_ChIP-Seq_ESCs_Human0.98349325
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.97740430
81TCF4_22108803_ChIP-Seq_LS180_Human0.96935228
82MYC_18940864_ChIP-ChIP_HL60_Human0.96090789
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95537073
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95446982
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94739979
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94610977
87RUNX2_22187159_ChIP-Seq_PCA_Human0.94258363
88DROSHA_22980978_ChIP-Seq_HELA_Human0.93990327
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93923150
90ETV1_20927104_ChIP-Seq_GIST48_Human0.92768690
91NANOG_19829295_ChIP-Seq_ESCs_Human0.92647401
92SOX2_19829295_ChIP-Seq_ESCs_Human0.92647401
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92584623
94TP53_18474530_ChIP-ChIP_U2OS_Human0.92164528
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91624682
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90316025
97HOXB7_26014856_ChIP-Seq_BT474_Human0.89953842
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89647427
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.89409792
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89200150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.69894312
2MP0000566_synostosis3.65751837
3MP0000579_abnormal_nail_morphology3.64563213
4MP0002653_abnormal_ependyma_morphology3.42910251
5MP0003122_maternal_imprinting3.33121269
6MP0001984_abnormal_olfaction2.85082028
7MP0003880_abnormal_central_pattern2.68319490
8MP0002102_abnormal_ear_morphology2.40167050
9MP0004885_abnormal_endolymph2.32292836
10MP0010234_abnormal_vibrissa_follicle2.31963331
11MP0003136_yellow_coat_color2.27119460
12MP0000569_abnormal_digit_pigmentation2.24499500
13MP0006276_abnormal_autonomic_nervous2.20491940
14MP0005377_hearing/vestibular/ear_phenot2.10345285
15MP0003878_abnormal_ear_physiology2.10345285
16MP0000778_abnormal_nervous_system2.02541363
17MP0008877_abnormal_DNA_methylation1.99120003
18MP0008789_abnormal_olfactory_epithelium1.92641737
19MP0001188_hyperpigmentation1.86185189
20MP0002876_abnormal_thyroid_physiology1.86031077
21MP0005645_abnormal_hypothalamus_physiol1.83395593
22MP0002095_abnormal_skin_pigmentation1.81553344
23MP0000383_abnormal_hair_follicle1.78901617
24MP0005499_abnormal_olfactory_system1.77443007
25MP0005394_taste/olfaction_phenotype1.77443007
26MP0010678_abnormal_skin_adnexa1.76922515
27MP0002796_impaired_skin_barrier1.76012042
28MP0004142_abnormal_muscle_tone1.74868425
29MP0004043_abnormal_pH_regulation1.74225391
30MP0008875_abnormal_xenobiotic_pharmacok1.65617432
31MP0003121_genomic_imprinting1.63780065
32MP0000015_abnormal_ear_pigmentation1.58579298
33MP0000647_abnormal_sebaceous_gland1.57519737
34MP0001529_abnormal_vocalization1.56968704
35MP0002234_abnormal_pharynx_morphology1.56687914
36MP0003011_delayed_dark_adaptation1.56627700
37MP0000427_abnormal_hair_cycle1.55789660
38MP0001905_abnormal_dopamine_level1.54330927
39MP0005275_abnormal_skin_tensile1.53909763
40MP0004742_abnormal_vestibular_system1.53810543
41MP0006072_abnormal_retinal_apoptosis1.47987889
42MP0005423_abnormal_somatic_nervous1.41945871
43MP0004133_heterotaxia1.40771518
44MP0000467_abnormal_esophagus_morphology1.38329692
45MP0003329_amyloid_beta_deposits1.37084051
46MP0002098_abnormal_vibrissa_morphology1.32747235
47MP0005253_abnormal_eye_physiology1.28773179
48MP0002557_abnormal_social/conspecific_i1.26488719
49MP0005174_abnormal_tail_pigmentation1.25289453
50MP0009745_abnormal_behavioral_response1.21317954
51MP0003635_abnormal_synaptic_transmissio1.20629895
52MP0001502_abnormal_circadian_rhythm1.20535608
53MP0003787_abnormal_imprinting1.20376919
54MP0005075_abnormal_melanosome_morpholog1.20178317
55MP0002272_abnormal_nervous_system1.19584728
56MP0001919_abnormal_reproductive_system1.19369497
57MP0001485_abnormal_pinna_reflex1.18770645
58MP0009046_muscle_twitch1.17782917
59MP0004381_abnormal_hair_follicle1.15409485
60MP0003941_abnormal_skin_development1.13422700
61MP0002572_abnormal_emotion/affect_behav1.13256350
62MP0000372_irregular_coat_pigmentation1.12928215
63MP0006292_abnormal_olfactory_placode1.12772991
64MP0001440_abnormal_grooming_behavior1.09563389
65MP0005551_abnormal_eye_electrophysiolog1.07108629
66MP0005389_reproductive_system_phenotype1.06401215
67MP0002638_abnormal_pupillary_reflex1.05219983
68MP0004924_abnormal_behavior1.04780839
69MP0005386_behavior/neurological_phenoty1.04780839
70MP0002063_abnormal_learning/memory/cond1.04456598
71MP0004859_abnormal_synaptic_plasticity1.02404140
72MP0001970_abnormal_pain_threshold1.02127729
73MP0002734_abnormal_mechanical_nocicepti0.99872459
74MP0001348_abnormal_lacrimal_gland0.99810541
75MP0002064_seizures0.98961331
76MP0002733_abnormal_thermal_nociception0.98835543
77MP0005195_abnormal_posterior_eye0.98829788
78MP0008872_abnormal_physiological_respon0.98393247
79MP0002909_abnormal_adrenal_gland0.97096118
80MP0002277_abnormal_respiratory_mucosa0.96941725
81MP0001968_abnormal_touch/_nociception0.96153464
82MP0000631_abnormal_neuroendocrine_gland0.94797499
83MP0004147_increased_porphyrin_level0.93984625
84MP0000026_abnormal_inner_ear0.93168349
85MP0001293_anophthalmia0.92762700
86MP0001216_abnormal_epidermal_layer0.90266395
87MP0004019_abnormal_vitamin_homeostasis0.88920535
88MP0010771_integument_phenotype0.87966102
89MP0002282_abnormal_trachea_morphology0.87838695
90MP0000955_abnormal_spinal_cord0.85758934
91MP0002184_abnormal_innervation0.85114032
92MP0000762_abnormal_tongue_morphology0.84295086
93MP0002736_abnormal_nociception_after0.83136816
94MP0005501_abnormal_skin_physiology0.83078431
95MP0000377_abnormal_hair_follicle0.82585779
96MP0002882_abnormal_neuron_morphology0.81294392
97MP0002067_abnormal_sensory_capabilities0.78590425
98MP0002752_abnormal_somatic_nervous0.77443997
99MP0002177_abnormal_outer_ear0.76598312
100MP0003890_abnormal_embryonic-extraembry0.75537886

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.01312447
2Absent/shortened dynein arms (HP:0200106)6.01312447
3Abnormal respiratory motile cilium morphology (HP:0005938)5.46399398
4Abnormal respiratory epithelium morphology (HP:0012253)5.46399398
5Abnormal ciliary motility (HP:0012262)5.24279259
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.12212668
7Abnormal respiratory motile cilium physiology (HP:0012261)5.11402956
8Rhinitis (HP:0012384)4.16641133
9Onycholysis (HP:0001806)3.96380302
10Abnormality of midbrain morphology (HP:0002418)3.84984466
11Molar tooth sign on MRI (HP:0002419)3.84984466
12Abnormality of nail color (HP:0100643)3.81426830
13Fragile nails (HP:0001808)3.78698794
14Plantar hyperkeratosis (HP:0007556)3.60971672
15Pancreatic cysts (HP:0001737)3.55030863
16Nephronophthisis (HP:0000090)3.42716859
17Type II lissencephaly (HP:0007260)3.28814479
18True hermaphroditism (HP:0010459)3.26943702
19Pancreatic fibrosis (HP:0100732)3.19105014
20Palmoplantar hyperkeratosis (HP:0000972)3.08293744
21Abnormality of the renal medulla (HP:0100957)2.93577069
22Chronic bronchitis (HP:0004469)2.90477181
23Palmar hyperkeratosis (HP:0010765)2.84794973
24Decreased central vision (HP:0007663)2.84561830
25Bronchiectasis (HP:0002110)2.76725180
26Hypotrichosis (HP:0001006)2.69177897
27Cerebellar dysplasia (HP:0007033)2.65411411
28Erythroderma (HP:0001019)2.65091194
29Polyphagia (HP:0002591)2.62041051
30Medial flaring of the eyebrow (HP:0010747)2.58766340
31Hypoplasia of the pons (HP:0012110)2.56109605
32Furrowed tongue (HP:0000221)2.55479909
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54885724
34Cystic liver disease (HP:0006706)2.48571352
35Milia (HP:0001056)2.48128154
36Lissencephaly (HP:0001339)2.44303408
37Gait imbalance (HP:0002141)2.41410462
38Large eyes (HP:0001090)2.39884511
39Alopecia of scalp (HP:0002293)2.38732376
40Abolished electroretinogram (ERG) (HP:0000550)2.32980769
41Hip dysplasia (HP:0001385)2.32742024
42Chronic hepatic failure (HP:0100626)2.32148262
43Postaxial foot polydactyly (HP:0001830)2.31991895
44Abnormality of the pons (HP:0007361)2.31878975
45Woolly hair (HP:0002224)2.29621959
46Sclerocornea (HP:0000647)2.22925134
47Congenital stationary night blindness (HP:0007642)2.20840745
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.17864313
49Abnormality of secondary sexual hair (HP:0009888)2.15072385
50Abnormality of the axillary hair (HP:0100134)2.15072385
51Thick nail (HP:0001805)2.12379686
52Tubular atrophy (HP:0000092)2.10265793
53Akinesia (HP:0002304)2.06965636
54Anophthalmia (HP:0000528)2.05879323
55Congenital primary aphakia (HP:0007707)2.03144128
56Asplenia (HP:0001746)2.02529067
57Labial hypoplasia (HP:0000066)2.02494797
58Limb dystonia (HP:0002451)2.01301811
59Congenital ichthyosiform erythroderma (HP:0007431)1.99658388
60Polydipsia (HP:0001959)1.98735381
61Abnormal drinking behavior (HP:0030082)1.98735381
62Parakeratosis (HP:0001036)1.96944012
63Abnormal rod and cone electroretinograms (HP:0008323)1.96532225
64Hypoplasia of the brainstem (HP:0002365)1.96525789
65Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96525789
66Hypoplastic labia majora (HP:0000059)1.91513108
67Chronic sinusitis (HP:0011109)1.90463203
68Oral leukoplakia (HP:0002745)1.90088116
69Nasal polyposis (HP:0100582)1.89766850
70Anencephaly (HP:0002323)1.86687346
71Aplasia/hypoplasia of the uterus (HP:0008684)1.85314068
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.85206036
73Hypoplasia of the uterus (HP:0000013)1.85039126
74Hypoplastic female external genitalia (HP:0012815)1.84163610
75Myokymia (HP:0002411)1.83732286
76Occipital encephalocele (HP:0002085)1.83186787
77Short tibia (HP:0005736)1.82348857
78Nail dystrophy (HP:0008404)1.81542469
79Agitation (HP:0000713)1.81133977
80Nephrogenic diabetes insipidus (HP:0009806)1.80085972
81Bile duct proliferation (HP:0001408)1.79843198
82Abnormal biliary tract physiology (HP:0012439)1.79843198
83Amblyopia (HP:0000646)1.79818666
84Congenital, generalized hypertrichosis (HP:0004540)1.78917278
85Postaxial hand polydactyly (HP:0001162)1.75589586
86Cutaneous finger syndactyly (HP:0010554)1.75061137
87Abnormality of the renal cortex (HP:0011035)1.73670787
88Congenital hepatic fibrosis (HP:0002612)1.72849152
89Abnormality of the labia majora (HP:0012881)1.70661683
90Pachygyria (HP:0001302)1.70407488
91Male pseudohermaphroditism (HP:0000037)1.70207281
92Amelogenesis imperfecta (HP:0000705)1.69804050
93Slow-growing hair (HP:0002217)1.69544077
94Abnormality of hair growth rate (HP:0011363)1.69544077
95Pendular nystagmus (HP:0012043)1.68431781
96Erythema (HP:0010783)1.68428994
97Hypohidrosis (HP:0000966)1.66642917
98Infertility (HP:0000789)1.65758186
99Corneal erosion (HP:0200020)1.59854943
100Cutaneous syndactyly (HP:0012725)1.59851876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.64488083
2MARK13.14883380
3EPHA43.03160949
4CASK2.88592756
5ADRBK22.47405908
6MAPK152.27723913
7FES2.16040816
8DYRK21.99945133
9BMPR1B1.95148672
10MAP3K111.85380362
11PINK11.84852669
12FER1.83247195
13TYRO31.81770349
14TLK11.75057930
15WNK31.73919928
16ZAK1.72081495
17MAPK131.63295172
18INSRR1.58131735
19BCR1.56235794
20WNK41.55382782
21PNCK1.49324475
22EPHB21.43166333
23MST41.38265979
24NTRK21.36886131
25OXSR11.33292464
26ERBB31.32862996
27PHKG21.31675568
28PHKG11.31675568
29FGFR21.30319903
30TAOK31.29104216
31GRK11.28005643
32NUAK11.24785094
33NEK11.23879791
34TNIK1.23701477
35PLK21.20366117
36TGFBR11.17846900
37NTRK31.17159607
38STK111.16759058
39ACVR1B1.15241968
40MAP3K41.13213582
41PAK31.11431027
42EPHA31.06641314
43ADRBK11.05393194
44MAPKAPK31.01969625
45PRKCG1.00359013
46PRKCI0.98791940
47STK240.98590727
48STK390.94718312
49PRKCE0.90993183
50CSNK1G20.83663340
51MAP4K20.82704787
52NEK20.80416321
53PIM20.79384615
54PKN10.78824321
55UHMK10.75453829
56LATS20.73243219
57PRKCZ0.66703292
58MAP2K20.64996931
59TXK0.64404779
60IKBKB0.62881381
61MAP2K70.62382342
62NTRK10.61816060
63TAOK10.60589367
64KSR10.55561243
65DYRK1A0.55013562
66AURKA0.54619580
67JAK30.54431174
68PRKCD0.53700947
69GRK50.53357474
70MAPKAPK50.52248259
71CHUK0.51979586
72MATK0.51487714
73TAF10.51241811
74CAMK10.50073623
75CHEK20.50024520
76PRKACA0.49517624
77MAP2K60.48834474
78RPS6KA50.48776002
79PRKCQ0.48396932
80VRK10.48297143
81EPHA20.47145174
82CSNK1G30.47003969
83NME10.46887816
84ERBB20.46264744
85BRSK20.44436165
86CSNK1D0.43099353
87NEK60.42158375
88BCKDK0.40545390
89MARK20.39341869
90MINK10.38530139
91MKNK20.38500621
92CSNK1A1L0.38470916
93FGFR30.37792058
94PRKCA0.37709042
95RPS6KA60.36205718
96PLK10.35390186
97RPS6KA20.35232484
98CSNK1G10.34530008
99CDK50.34252719
100CAMK2A0.33272532

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.05817051
2Linoleic acid metabolism_Homo sapiens_hsa005913.72053962
3Phototransduction_Homo sapiens_hsa047443.05383121
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.79052519
5Ether lipid metabolism_Homo sapiens_hsa005652.73334107
6Nicotine addiction_Homo sapiens_hsa050332.19896285
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11619959
8Oxidative phosphorylation_Homo sapiens_hsa001902.05911455
9Cardiac muscle contraction_Homo sapiens_hsa042602.01962067
10Arachidonic acid metabolism_Homo sapiens_hsa005902.01528389
11Ribosome_Homo sapiens_hsa030101.71156197
12Tryptophan metabolism_Homo sapiens_hsa003801.63807470
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60958298
14Olfactory transduction_Homo sapiens_hsa047401.60433681
15Parkinsons disease_Homo sapiens_hsa050121.59904292
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56361481
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55730365
18Nitrogen metabolism_Homo sapiens_hsa009101.48367419
19Huntingtons disease_Homo sapiens_hsa050161.47987133
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.45057868
21Protein export_Homo sapiens_hsa030601.44818737
22Sphingolipid metabolism_Homo sapiens_hsa006001.37366221
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36290582
24Alzheimers disease_Homo sapiens_hsa050101.35417051
25Butanoate metabolism_Homo sapiens_hsa006501.33333887
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32312514
27Serotonergic synapse_Homo sapiens_hsa047261.27632868
28Histidine metabolism_Homo sapiens_hsa003401.27179033
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25393704
30Glutamatergic synapse_Homo sapiens_hsa047241.22654425
31Circadian entrainment_Homo sapiens_hsa047131.22576566
32GABAergic synapse_Homo sapiens_hsa047271.18164622
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17513532
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.17152195
35Collecting duct acid secretion_Homo sapiens_hsa049661.15879163
36Chemical carcinogenesis_Homo sapiens_hsa052041.15736199
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15602383
38Morphine addiction_Homo sapiens_hsa050321.14394506
39Synaptic vesicle cycle_Homo sapiens_hsa047211.12555755
40Insulin secretion_Homo sapiens_hsa049111.10580462
41Dopaminergic synapse_Homo sapiens_hsa047281.10505193
42Salivary secretion_Homo sapiens_hsa049701.09469548
43Fanconi anemia pathway_Homo sapiens_hsa034601.08951833
44Axon guidance_Homo sapiens_hsa043601.07782498
45Taste transduction_Homo sapiens_hsa047421.04915854
46Retinol metabolism_Homo sapiens_hsa008301.01447423
47Ovarian steroidogenesis_Homo sapiens_hsa049130.98941698
48Caffeine metabolism_Homo sapiens_hsa002320.98690141
49Dorso-ventral axis formation_Homo sapiens_hsa043200.98567903
50Gastric acid secretion_Homo sapiens_hsa049710.97449203
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97044543
52Peroxisome_Homo sapiens_hsa041460.96783263
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96770786
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96273052
55Steroid biosynthesis_Homo sapiens_hsa001000.96128514
56beta-Alanine metabolism_Homo sapiens_hsa004100.95461631
57Selenocompound metabolism_Homo sapiens_hsa004500.91936303
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.89259148
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88485601
60Fatty acid elongation_Homo sapiens_hsa000620.87149247
61Hedgehog signaling pathway_Homo sapiens_hsa043400.83846801
62Long-term depression_Homo sapiens_hsa047300.83289472
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81435560
64Homologous recombination_Homo sapiens_hsa034400.78703337
65Fatty acid degradation_Homo sapiens_hsa000710.78443372
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77421232
67Renin secretion_Homo sapiens_hsa049240.76891325
68Fat digestion and absorption_Homo sapiens_hsa049750.76399760
69Hippo signaling pathway_Homo sapiens_hsa043900.71620164
70* p53 signaling pathway_Homo sapiens_hsa041150.71193048
71ABC transporters_Homo sapiens_hsa020100.71111274
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68955898
73Oxytocin signaling pathway_Homo sapiens_hsa049210.68687687
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67492075
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.67088251
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.66955853
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65524028
78Tyrosine metabolism_Homo sapiens_hsa003500.64383658
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63097946
80Basal cell carcinoma_Homo sapiens_hsa052170.62323998
81Alcoholism_Homo sapiens_hsa050340.62308927
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62237095
83Basal transcription factors_Homo sapiens_hsa030220.59600971
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58521099
85Mineral absorption_Homo sapiens_hsa049780.55619180
86Glycerolipid metabolism_Homo sapiens_hsa005610.54320475
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53487974
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51651946
89Lysosome_Homo sapiens_hsa041420.50905205
90Amphetamine addiction_Homo sapiens_hsa050310.50018161
91Pancreatic secretion_Homo sapiens_hsa049720.47834206
92Cholinergic synapse_Homo sapiens_hsa047250.47369889
93Metabolic pathways_Homo sapiens_hsa011000.45280622
94Asthma_Homo sapiens_hsa053100.44010396
95cAMP signaling pathway_Homo sapiens_hsa040240.43665582
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41583315
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41007622
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.39500575
99Calcium signaling pathway_Homo sapiens_hsa040200.39302290
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39243874

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